WORLD MEDICAL INNOVATION FORUMSM

NEUROSCIENCES | APRIL 27-29, 2015

The World Medical Innovation Forum features CEOs of industry-leading multinational medical companies, Partners HealthCare top clinicians and scientists—all Harvard Medical School faculty members—and global technology leaders. Join 1,000 international innovation decision-makers and be briefed on the state of the art in neuroscience technology, care and research directly from the CEOs bringing game- changing products to market, world-class clinicians delivering the highest-quality care and the scientists rapidly propelling this crucial field forward through their CNS insights and discoveries. Additionally, the industry-wide issues driving investment, application and reimbursement of innovation during this period of profound transformation in healthcare will be debated.

Disruptive technologies in genomics, imaging and informatics are driving fundamental change in the American health care system at the same time it is being transformed from volume-based care toward one organized around value, patient outcomes and sustained health. In the neurosciences, a series of new technologies are challenging long-accepted limits of diagnosis and care while population health initiatives are changing management of chronic neurologic and psychiatric disease.

World MedicalInnovation Forum

Headquartered in Boston, Massachusetts,

Partners HealthCare is one of the most highly

regarded hospital systems in the United

States. Its founding institutions, Brigham

and Women’s Hospital and Massachusetts

General Hospital, are staffed by Harvard

Medical School faculty and have a legacy of

innovation that includes 18 Nobel Laureates

and therapies that have redefined the

contemporary standard of care. It is the

largest academic research enterprise in

the nation at nearly $1.5 billion of annual

research. The work of its clinicians and

scientists are responsible for hundreds

of products and best practices. Partners’

leadership is committed to using its special

place in the global health care community to

ensure that innovation is a growing priority

in healthcare worldwide.

Chief executives of some of the largest and most important companies in health care, including GE, Novartis, Amgen, Biogen, Boston Scientific, Vertex and dozens of other CEOs will join Harvard clinical and research faculty— all leading physicians and scientists from Brigham and Women’s Hospital (BWH), Massachusetts General Hospital (MGH) and McLean Hospital, including Atul Gawande, MD, and Rudy Tanzi, PhD—and investors, entrepreneurs, senior government executives, corporate officers and top journalists in the Forum’s two-and-a-half-day gathering.

The inaugural World Medical Innovation Forum will be held in Boston April 27-29, 2015. Current and emerging approaches to diagnosing and caring for neurologic and psychiatric disorders will be highlighted, including multiple sclerosis, Alzheimer’s disease, Parkinson’s, depression, schizophrenia, autism, stroke and sleep disorders. Also, game-changing diagnostic tools and therapeutic interventions will be presented, including genome editing, gene therapy, neurostimulation, neuroregeneration, population management, neuroimaging and novel biomarkers.

The World Forum is organized around one clinical field per year—neurosciences in 2015 followed by cancer in 2016. The annual Forum provides attendees and policy makers with actionable insights into the torrent of new technology in the neurosciences and the swiftly evolving business of health care innovation. Attendees are senior executives of large companies, investors, entrepreneurs and officers of venture‐backed companies, business-minded clinicians and investigators, government principals and dealmakers. Participants include a significant complement of international leaders and organizations.

P A R T N E R S H E A L T H C A R E

Keynoters

MON. APRIL 27, 20152:00 PM - 8:00 PM

TUES. APRIL 28, 20157:30 AM - 9:00 PM

WED. APRIL 29, 20158:00 AM - 2:00 PM

Alzheimer’s Phoenix: New Technology, New Economics

Autism and Neurodevelopment: Are Therapies Possible Today?

Gene Editing, Gene Therapy, and the Eye as a Gateway

Gene to Drug: Kansas to Oz, Can it Happen in the Real World?

MS Transformed: Harnessing Biology and Inflammation

National Security through Neurodevelopment: Country Initiatives to Meet CNS Challenges

Neurocare, Neuromarkets, and Neuro Challenges

Neurostimulation: First-Line Therapy?

New Leaders at the Table: Filling the Gap Through Philanthropy?

Olympus Explained: Neuroinvesting from the Summit

Over the Horizon: Witnessing the Disruption of Neurocare

Parkinson’s Disease: Finally Crossing the Therapeutic Threshold

Psychiatric Targets: Finally New Mechanisms?

Regeneration, Cell Therapy, and Neurocare: Products? Delivery?

Sleep and Consciousness: Clinical Need Versus Chronic Use

Technology, Pathology, Radiology: Changing the Game Through Neurodiagnostics

The Disruptive Dozen: 12 Technologies that will Reinvent Neurocare

Topics World Medical Innovation Forum | Neurosciences

Jeff ImmeltCEO, General Electric

Robert BradwayCEO, Amgen

George Scangos, PhDCEO, Biogen Idec

David Meeker, MDPresident, CEO, Genzyme

Rudy Tanzi, PhDMGH Neurology, Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation,Harvard Medical School

Atul Gawande, MDSurgeon, BWH, Professor,Harvard Medical School

Mark Fishman, MDPresident, Novartis Institutes for BioMedical Research (NIBR)

Joe JimenezCEO, Novartis

Kyra PhillipsAnchor and Correspondent, CNN

Jeff Leiden, MD, PhDChairman, CEO,Vertex Pharmaceuticals

Peter Orszag, PhDVice Chairman, Corporate and Investment Banking, Citigroup

Mike MahoneyCEO, Boston Scientific

Ann RomneyGlobal Ambassador, Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital

Alfred Sandrock, MD, PhDGroup Senior Vice President, CMO, Biogen Idec

From start to finish

every speaker an expert, every panel unique -an unrivaled view into CNS discovery, technologies,markets, and healthcare innovation overall

Featured Speakers

Nathalie Agar, PhDBWH Neurosurgery, Assistant Professorof Radiology, Harvard Medical SchoolMark Albers, MD, PhDMGH Neurology, Frank and Maureen Wilkins Endowed Chair in Alzheimer's Research, Harvard Medical SchoolDavid Altshuler, MD, PhDMGH Molecular Biology,Professor of Genetics and Medicine,Harvard Medical SchoolFrank Bennett, PhDSenior Vice President of Research,Isis PharmaceuticalsMatt T. Bianchi, MD, PhDMGH Neurology, Assistant Professorof Neurology, Harvard Medical SchoolKatrine BosleyCEO, Editas MedicineRobert BradwayCEO, AmgenDavid BrennanCEO, AstraZeneca (Ret.)Emery Brown, MD, PhDMGH Anesthesia, Warren M. Zapol Professor of Anaesthesia,Harvard Medical SchoolRandall Carpenter, MDResearch Affiliate, MITAntonio Chiocca, MD, PhDChairman, BWH Neurosurgery, Harvey W. Cushing Professor of Neurosurgery, Harvard Medical SchoolTim Coetzee, PhDChief Advocacy, Services,and Research Officer,National Multiple Sclerosis SocietyDoug Cole, MDGeneral Partner, Flagship VenturesDuke CollierExecutive Chairman, Arsenal MedicalMeryl ComerPresident, Geoffrey Beene Foundation Alzheimer’s Initiative

Michelle CortezReporter, Bloomberg BusinessweekJoseph Coyle, MDCSO, McLean Hospital,Eben S. Draper Professor of Psychiatry,Harvard Medical SchoolMerit Cudkowicz, MDChairman, MGH Neurology,Julieanne Dorn Professor of Neurology,Harvard Medical SchoolCharles Czeisler, PhD, MDBWH Medicine and Neurology,Baldino Professor of Sleep Medicine, Harvard Medical SchoolMark Daly, PhDMGH Analytic and Translational Genetics, Associate Professor of Medicine, Harvard Medical SchoolMark Demitrack, MDCMO, NeuroneticsRicardo Dolmetsch, PhDGlobal Head of Neuroscience, Novartis Institutes for BioMedical ResearchDeborah Dunsire, MDCEO, Forum PharmaceuticalsMichael Ehlers, MD, PhDNeuroscience CSO, PfizerEmad Eskandar, MDMGH Neurosurgery, Charles Pappas Professor of Neurosurgery,Harvard Medical SchoolMaurizio Fava, MDExecutive Vice Chair, MGH Psychiatry, Professor of Psychiatry,Harvard Medical SchoolFrank FischerCEO, NeuroPaceMark Fishman, MDPresident, Novartis Institutesfor BioMedical Research (NIBR)Peter FordFounder and CEO, Control BionicsJean-François Formela, MDPartner, Atlas Ventures

Ole Isacson, MDMcLean Neuroregeneration Research,Professor of Neurology,Harvard Medical SchoolJoe JimenezCEO, NovartisRajiv KaulSelect Biotechnology Portfolio and Advisor Biotechnology Fund, Fidelity InvestmentsAnne Klibanski, MDChief Academic Officer, Partners HealthCare, Laurie Carrol Guthart Professor of Medicine,Harvard Medical SchoolScott KirsnerColumnist, The Boston GlobeJeffrey Leiden, MD, PhDCEO, Vertex PharmaceuticalsGeoffrey Ling, MD, PhDDirector, Biological Technologies Office, DARPADavid Louis, MDPathologist in Chief, MGH, Benjamin Castleman Professor of Pathology,Harvard Medical SchoolMike MahoneyCEO, Boston ScientificHenry McCanceChairman Emeritus, Greylock PartnersChristopher McDougle, MDDirector, Lurie Center for Autism,MGH for Children, Nancy Lurie Marks Professor of Autism, Harvard Medical SchoolMartin McGlynnCEO, StemCellsDavid Meeker, MDPresident, CEO, GenzymeDoug Melton, PhDSaris University Professor, Harvard University, Investigator, Howard Hughes Medical Institute, Co-Chair, Department of Stem Cell and Regenerative BiologyGregg Meyer, MDChief Clinical Officer, Partners HealthCareMatt MillerHost, NPRShawn Murphy, MD, PhDPartners HealthCare Research Information Systems and Computing, Associate Professor of Neurology, Harvard Medical SchoolBetsy Nabel, MDPresident, BWH, Professor of Medicine,Harvard Medical School

Pete FratesChampion, ALS Ice Bucket ChallengeNancy FratesThe Pete Frates #3 FundAtul Gawande, MDBWH Surgery, Professor of Surgery,Harvard Medical SchoolGideon GilHealth and Science Editor,The Boston GlobeAlexandra Golby, MDBWH Neurosurgery, Associate Professor,Harvard Medical SchoolJeffrey Golden, MDChairman, BWH Pathology,Ramzi S. Cotran Professor of Pathology,Harvard Medical SchoolCorey Goodman, PhDManaging Partner, venBioGary Gottlieb, MDCEO, Partners HealthCare, Professorof Psychiatry, Harvard Medical SchoolPhillip Gregory, D. Phil,Senior Vice President and CSO, Sangamo BioSciencesRich Gregory, PhDHead of Genzyme R&D CenterJeffrey Gulcher, MD, PhDPresident and CSO, NextCODE HealthSean Harper, MD, PhDExecutive Vice President,Research and Development, AmgenMartha Herbert, MD, PhDMGH Neurology, Assistant Professorof Neurology, Harvard Medical SchoolLeigh Hochberg, MD, PhDMGH Neurology, Senior Lecturer on Neurology, Harvard Medical SchoolMichael Hodin, PhDExecutive Director, Global Coalition on Aging, Managing Partner, High Lantern GroupMichael Hutton, PhDCSO, Neurodegenerative Diseases,Eli Lilly & Co.Brad Hyman, MD, PhDMGH Neurology, John B. Penney Jr. Professor of Neurology,Harvard Medical SchoolJeff ImmeltCEO, General Electric

Chris O’ConnellExecutive Vice President and Group President, Restorative Therapies Group, MedtronicPeter OrszagVice Chairman, Corporate and Investment Banking, CitigroupAlice ParkWriter, TIME MagazineRoy Perlis, MDMGH Psychiatry, Associate Professorof Psychiatry, Harvard Medical SchoolKyra PhillipsAnchor and Correspondent, CNNEric Pierce, MD, PhDMassachusetts Eye and Ear Infirmary, Solman and Libe Friedman Associate Professor of Ophthalmology,Harvard Medical SchoolBen PlessCEO, ATIScott Rauch, MDPresident and Psychiatrist in Chief, McLean Hospital, Professor of Psychiatry, Harvard Medical SchoolJohn RobertsSenior National Correspondent, Fox NewsAnn RomneyGlobal Ambassador, Ann Romney Center for Neurologic Diseases at Brigham and Women’s HospitalBruce Rosen, MD, PhDMGH Neurology, Professor of Radiology,Harvard Medical SchoolJerrold Rosenbaum, MDPsychiatrist in Chief, MGH,Stanley Cobb Professor of Psychiatry,Harvard Medical SchoolBill SahlmanDimitri V. D’Arbeloff - MBA Class of 1955 Professor of Business Administration, Senior Associate Dean for External Relations, Harvard Business SchoolAlfred Sandrock, MD, PhDGroup Senior Vice President,CMO, Biogen IdecDavid Scadden, MDMGH Regenerative Medicine, Gerald and Darlene Jordan Professor of Medicine, Harvard Medical SchoolGeorge Scangos, PhDCEO, Biogen Idec

Dale Schenk, PhDCEO, ProthenaClemens Scherzer, MDBWH Neurology, Associate Professorof Neurology, Harvard Medical SchoolMichael Schwarzschild, MD, PhDMGH Neurology, Professor of Neurology,Harvard Medical SchoolDennis Selkoe, MDBWH Neurology, Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical SchoolTodd Sherer, PhDCEO, The Michael J. Fox Foundationfor Parkinson's ResearchSue SiegelCEO, GE Ventures & healthymaginationDavid Silbersweig, MDChairman, BWH Psychiatry,Stanley Cobb Professor of Psychiatry,Harvard Medical SchoolMoncef Slaoui, PhDChairman of Global R&D and Vaccines, GlaxoSmithKlinePeter Slavin, MDPresident, MGH, Professor of Healthcare Policy, Harvard Medical SchoolNancy Snyderman, MDChief Medical Editor, NBC NewsGreg Sorenson, MDCEO, Siemens Healthcare North AmericaRudy Tanzi, PhDMGH Neurology, Joseph P. and Rose F. Kennedy Professor of Child Neurologyand Mental Retardation,Harvard Medical SchoolMeg TirrellBiotech & Pharma Reporter, CNBCSteven TregayCEO, Forma TherapeuticsAjay Verma, MD, PhDVP, Experimental Medicine, Biogen IdecJeff WalkerVice Chair, United Nations Envoy's Office for Health Finance and MalariaHoward Weiner, MDPartners HealthCare Multiple Sclerosis Center, Robert L. Kroc Professor of Neurology, Harvard Medical School* Additional Speakers Being Confirmed

Join Us for the 2015 World Medical Innovation Forum

Experience the state of the art in neuroscience technology, care and research

Understand the prospects for innovation in a transformed health care industry

See firsthand the breakthrough neuro technologies from across the industry

Forge relationships and exchange information with world-recognized clinicians, investors, entrepreneurs, scientists, CEOs, executives, government leaders, philanthropists, and journalists

101 Huntington Avenue, 4th Floor | Boston, MA 02199

617-954-9500 | innovation.partners.org

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