Working with Histamine Overload April 2013

Methods we used to lower our young son’s histamine burden,

to reduce the frequency and intensity of dangerous and painful

histamine mediated reactions.

Copyright Tiffany Blackden 2013All Rights Reserved

The Mastocytosis SocietyDC Regional Regional Meeting

April 2013

Copyright Tiffany Blackden 2013 All Rights Reserved

Our family!

The reasons we’ve stayed up all night researching and continuing to figure

out ways to support health!

Mast Cell Activation SyndromeI.SystemicAnaphylaxisFaintnessFatigue II.DermatologicFlushingRashesItchingHives

III.CardiovascularBlood pressure

changes and shockChest painRapid heart rate IV.PulmonaryWheezing


V.Musculoskeletal

Bone pain

Muscle pain

Degenerative disc disease

Osteoporosis/osteopenia

VI.Gastrointestinal

Nausea

Vomiting

Abdominal pain

Gastroesophageal reflux

Diarrhea

Inflammation of the esophagus

Intestinal cramping and bloating

Malabsorption

VII.NeurologicCognitive

difficulties/brain fogDizziness/vertigoLightheadednessMigraine headacheParesthesiaPeripheral neuropathy


Max’s Daily MCAS PresentationHives, dermatographia, flushing, swelling,

stomachaches, headaches, fatigue, stuffiness, dizziness, reflux, diarrhea, leg pain, itching from:Foods (too many to name!)FrictionHeatColdChange in tempAnimalsChemicalsSynthetic FabricsSkin Contact With Plants/GrassEtc…???


A few of his reactions:


Blisters on both lower legs after consuming olive oil.

Rolled around on synthetic rug…

taken after the hives calmed down a bit.

Really angry reaction from playing with a scratchy rope. This was after it was calm, we nearly went to the hospital, it covered much of his torso and his left arm.

Max’s Health Team:Naturopathic DoctorsNationally Certified NutritionistsAcupuncturist - BioSet PractitionerChinese Medicine PractitionerOsteopathic Doctor (D.O.)ChiropractorMD HomeopathBiomedical MDHis Mommy, Daddy and Sister


What’s in a mast cell?


Today we are focusing on HISTAMINE…

Art by: Angela Canada Hopkinshttp://www.canadahopkins.com/

Over 100 different molecules that protect the body, as well as causing inflammation.

Preformed mediators : (from granules)-Serine proteases-Tryptase-Histamine-Serotonin-Proteoglycans-mainly heparin

Newly formed Lipid Mediators: (eicosanoids)-Thromboxane-Prostoglandins-Leukotreines-Platelet Activating Factor-Cytokines

The reasons we focused on lowering the systemic histamine burden:

First step in protocol for mast cell disorders is antihistamines, primarily H1 and H2 drugs.

Mast cells have histamine receptors on the cell membrance that make them more ready to degranulate or selectively secrete mediators.

Dietary histamine (and other biogenic amines, like tyramine) was a primary *group* of foods that were bothering our son.



Local Immune Response for Injury

Protective Mechanism in ‘Boundary’ Tissues

Regulates Smooth Muscle Contraction

Neurotransmitter

Histamine Affects Every System of the Body

NeurologicalCardiovascularMusculoskeletalGastrointestinalReproductiveRespiratoryCutaneous


It is produced in mast cells, basophils, platelets, neutrophils and some neurons…and stored intracellularly, then released when stimulated.

Histamine Receptors:H1: Smooth Muscle, Endothelium, Central

Nervous System Tissue, Mast Cells

H2: Gastrointestinal, Vascular Smooth Muscle Tissue, Mast Cells

H3: Central Nervous System and Some Peripheral Nervous System, Mast Cells

H4 (Just discovered in 2000): Bone Marrow, Basophils, Thymus, Small Intestine, Spleen, Colon, Mast Cells


Sources of Histamine:Normal Metabolic Function Throughout BodyDietary Histamine Foods That Release Histamine From Mast

CellsIgE (Allergy) Mast Cell Degranulation Non-IgE (Trigger)Mast Cell DegranulationBacteria


Histamine Burden is cumulative over the course of a day (sometimes persisting beyond a day, if the burden is high).

Control what you CAN, to keep the cup from overflowing with all the factors *not* in your control.


Histamine Overload…


Histamine for Digestion (histamine secreted to release stomach acid in normal digestion) Pineapple (contains histamine AND

can release histamine directly from cells)

Sodium Benzoate in Soda (common food/beverage preservative and mc degranulator)

Cat Dander (IgE)

Ragweed (IgE)

Hot Day/Pressure/Friction/ Vibration (all physical mast cell triggers)

Chicken Leftover in Fridge (histamine produced by proteins breaking down)

Combination of IgE, endogenous (made inside the body), naturally occurring dietary histamine, physical triggers, and consumption of histamine releasing substances.

Avoiding High Histamine Pitfalls…All of these can increase your histamine burden, or decrease your body’s ability to process histamine.

Fermented FoodsCured FoodsDyesPreservatives/AdditivesSulphitesRefrigerated Leftovers (we freeze them)AlcoholHigh Histamine FoodsHistamine Releasing FoodsHistamine Degrading Enzyme Inhibiting

ChemicalsCopyright Tiffany Blackden 2013 All Rights Reserved

Some Histamine Liberating or DAO/HMT Inhibiting MedsSubstance class Some Active agents Radiological Contrast media Muscle relaxants Pancuronium, Alcuronium, D-

Tubocurarin Narcotics Thiopental Analgesics Morphine, pethidine, NSAR, ASS,

metamizole Local anesthetics Prilocaine Antihistamines Dyphenhydramine Antihypotensives Dobutamine Antihypertensives Verapamil, alprenolol, dihydralazine Antiarrhythmics Propafenon Diuretics Amiloride Motility agents Metoclopramide Antibiotics Cefuroxime, cefotiam,

isoniazid,pentamidine, clavulanic acid, chloroquine

Mucolytics Acetylcysteine, ambroxol Broncholytics Aminophylline H2 receptor antagonists Cimetidine Cytostatics Cyclophosphamide Antidepressants Amitriptylline


Now we know how we get histamine IN our systems…

How Does Histamine *EXIT* Our Bodies?


Deactivation AND Liver Metabolism

Enzymes that BREAK DOWN Histamine:o DAO (Diamine Oxidase)o HMT/HNMT (Histamine Methyltransferase)o MAO A (Monoamine Oxidase A)

Phase I & II Liver Detoxificationo Methylation o Sulfationo Oxidation


Functional Bottleneck: What other molecules use the *same exit pathways* as histamine (and other inflammatory mediators)?

MedicationsPesticidesHerbicidesHormonesBacteriaAntibodiesNeurotransmittersChemical FragrancesInhaled ChemicalsChemicals in Municipal WaterPreservatives in Food and Body ProductsAdditives in Food and Body ProductsDyesMore…


Ways to Help the Liver Flush Histamine

Reduce overall chemical load.Move lymph in our bodies.Exercise.Lower our stress level.Drink lots of clean water.Get adequate nutrients for

detoxification.


REDUCING OVERALL CHEMICAL LOAD-Indirect Contact

YardInsect Repellants, Weed Killers, Fertilizers

Home Cleaning, Air freshening, Painting, Construction, Pet products

Public Placesstores with fragrance everywhere, airborne chemicals

from products in stores, people with perfume/detergent/dryer sheet

HobbyPaints, Compounds, Gasoline, Carbon Monoxide,

Polishes, Cleaning ProductsCopyright Tiffany Blackden 2013 All Rights Reserved

REDUCING OVERALL CHEMICAL LOAD – Direct Contact

BodySoaps, Shampoo/Conditioner,

Lotions, Hair Sprays, Nail Products, Toothpaste Deodorant

Clothes with chemicals from detergents/dryer sheets

FoodAdditives, Preservatives,

Sweeteners, Pesticides, Herbicides, Plastics, Chemicals from municipal water (Chlorine, Fluoride, Aluminum, Antibiotics, Hormones, etc)


California Baby Bubble Bath

Mast Cell Degranulating Preservative

Some doctors in Europe treat histamine intolerance as a progressing disease process…histamine has role in chemotaxis (programmed cell

death), so could an enzyme deficiency or chronic, systemic build up of histamine be related to mast cell proliferation (mastocytosis)?

MastocytosisMCAD

Hypersensitivity DisorderHistaminosis

Histamine IntoleranceCopyright Tiffany Blackden 2013 All Rights Reserved

Mast Cell – Histamine Diaries

Foods (Sensitivities/Histamine/Glycemic Index)Beverages (Hydration Level/Dyes/Sweeteners)Exposures (Pollen/Stores/Chemicals/Smells)Reactions (Type/Duration/Medication)Sleep (Amount/Quality)Emotional State

(Anxious/Depressed/Happy/Stressed)


Our Daily High Quality NutritionDrink plenty of good quality water EVERY day. Low Histamine/Tyramine/Other Biogenic Amines, Organic

Whole Foods (locally grown when possible) Rotate Foods As Much As Possible No Gluten/Dairy/Soy/Eggs/Nuts/Citrus/Dyes/Additives

Preservatives/Polyunsaturated Fats Only grass fed beef, venison and wild caught fish Good quality fats daily(No PUFAs, we use ghee and coconut oil) Digestive Enzymes Sources of Trace Minerals (Pink Himalayan Salt, Dulse Flakes

& Wakame, Superdupermineralpackedwheatgrass juice) Some High Quality Supplements (Vit D, Vit K2, Mitochondrial

Support Supps-CoQ10, l-carnitine, d-ribose and magnesium) Raw Leafy Greens (methylation support)


Other Daily Health SupportHydration, Hydration, HydrationDense NutritionEpsom Salt Baths Almost Daily (Additional

Magnesium Chloride Spray as Needed)Moderate Exercise-Play, Mini TrampolineClean AirGood Quality SleepLimit All Man-made Chemical Exposure PossibleAyurvedic-Style Meal Preparation (60%+ of calories

by 1pm)12 Hour Night Fast (Liver Function Support)Low Stress


Locally grown, organic when possible:Helps us avoid GMOs, Herbicides, Pesticides

This food has more micronutrients, more live enzymes, was JUST harvested (not weeks ago, ripening on a truck) and hasn’t been sprayed with a preservative at a grocery

store(which is derived from GMO corn).


What MCAS has taught us: WE are responsible for our family’s healthcare…it is necessary to understand

as much as we can, so we can make the lifestyle changes necessary for health.

We *hire* doctors, and can choose the team that serves us best. We require that they are open minded and willing to do some research, since this disease is such an unknown. Much of our most effective care has been out of pocket and on the periphery of traditional western medicine.

Stress has a dramatic effect on our health. This can NOT be overstated, when mast cells and histamine levels are involved.

Eating right and living in a way that has allowed a healthier life was not easy (we moved across country, let our beloved pets go, change our diet, change all of our household and personal care products and homeschool to help our son), but every step we’ve taken has brought us to a more complete level of health and wellness.

It’s a marathon, that requires daily effort. It can’t be done as a sprint…little changes, consistently added, allow for some sense of balance as you go along the path.

When you have a chronically sick child, it is vitally important to take care of yourself.

We must trust our intuition.Copyright Tiffany Blackden 2013 All Rights Reserved

Get in touch, get support…Please connect with me:

Tiffany Blackden on Facebook, Twitter or LinkedIn

Email: [email protected]

Join Facebook Group: “Mastocytosis – Holistic Approach”

Our FB page for our medical journey & research: www.Facebook.com/blackdenfamily


Working with Histamine Overload April 2013

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