Wildtype versus Mutant
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Transcript of Wildtype versus Mutant
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Wildtype versus Mutant
Arora LabUniversity of California Irvine
Developmental and Cell Biology
Department
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UC Irvine
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Dr. Kavita AroraDr. Kavita Arora
Associate Professor
J. ChoJ. Cho
PhD StudentPhD Student
M. AlvarezM. Alvarez
PhD StudentPhD Student
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What is the difference between these individuals?
• Wolverine is a mutant and Ms. Alvarez is wild-type• Wild-type is the typical form• Mutants are organisms who’s DNA has been
altered. These organisms display new characteristics or traits not found in wild-type.
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Mutations are permanent changes in
the DNA sequence of a gene
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Why do scientist make mutant organisms?
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• To study the function/ role of the gene that has been mutated.
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Drosophila Melanogaster, a popular genetic model organism
• ~ 50% of fly genes have vertebrate homologs
• Small and easy to grow in lab
• Short generation time • Produce high
amounts of offspring
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Drosophila Melanogaster is used to study the biological processes
underlying: • Embryonic
development • Neurodegenerative
disorders • Diabetes• Aging• Drug abuse• Cancer
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Myostatin Mutants
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Project goal: Identify the function of Myostatin in
Drosophila Myostatin fly mutants die at pupa stage
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• Dr. Kavita Arora • Jane Cho • Tiffany Leung• Nicole El-Ali• Arora Lab• Warrior Lab• MSP Program• NSF-GK-12 grant DGE-0638751
Acknowledgments