Which of the following cells are involved in the pathogenesis of rheumatoid arthritis? 1.B cell 2.T...
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Transcript of Which of the following cells are involved in the pathogenesis of rheumatoid arthritis? 1.B cell 2.T...
Which of the following cells are involved in the pathogenesis of rheumatoid arthritis?
1. B cell2. T cell3. Macrophage4. All of above
Which of the followings is not anti-TNF?
1. Rituximab2. Etanercept3. Adalimumab4. Golimumab
DAS-28 is used to assess the disease activity of which disease?
1. systemic lupus erythematosus2. rheumatoid arthritis3. ankylosing spondylitis4. osteoporosis
The following side effects are increased with anti-TNF therapy except
1. Infection 2. Tuberculosis3. Hepatits B4. Lymphoma
The TB incidence rate in Taiwan is around
1. 10-24 /100,000 population2. 24-49/ 100,000 population 3. 50-100/100,000 population4. 100-299/100,000 population
Which is the correct statement regarding screen tests TST (tuberculin skin test) and IGRA (interferon-r release assay) for latent TB infection ?
1. TST is of better sensitivity than IGRA2. IGRA is of better sensitivity than TST3. TST is of better specificity than IGRA4. IGRA is of better specificity than TST
Which of the following treatment carries the highest risk of HBV reactivation
1. Methotrexate2. Steroid3. Anti-TNF plus steroid4. Rituximab plus steroid
Which of the following antiviral drugs carry the higher risk of emergence of HBV mutant variant?
1. Lamivudine2. Adefovir3. Entecavir4. Telbivudine
Which of the following cells are involved in the pathogenesis of rheumatoid arthritis?
1. B cell2. T cell3. Macrophage4. All of above
Choy EH, Panayi GS. N Engl J Med 2001;344:907-916
Cytokine signalling pathways involved in RA
11
RF
Plasma cell
B cell
Synovium
Osteoclast
OPGL
Fibroblast
IL-4IL-6
IL-10
IL-4IL-10
IFNgIL-12
ThO
IFNg
CD69 CD11
CD4 + T cellCD11
CD69TNFIL-1IL-6
MacrophageTh2
Production of metalloproteinases and other effector molecules
Migration of polymorphonuclear cells
Erosion of bone and cartilage
Chondrocyte
EtanerceptInfliximab
AdalimumabGolimumabCertolizuma
bRituximab
Tocilizumab
Tocilizumab
Abatacept
Which of the followings is not anti-TNF?
1. Rituximab2. Etanercept3. Adalimumab4. Golimumab
Woodrick, R. S. & Ruderman, E. M. Nat. Rev. Rheumatol. 7, 639–652 (2011)
DAS-28 is used to assess the disease activity of which disease?
1. systemic lupus erythematosus2. rheumatoid arthritis3. ankylosing spondylitis4. osteoporosis
Measures of disease activity of rheumatoid arthritis DAS-28, SDAI, CDAI
1. Remission (緩解 ) 2. Low disease activity (低度疾病活動度 ) 3. Moderate disease activity (中度疾病活動度 ) 4. High disease activity (重度疾病活動度 )
The following side effects are increased with anti-TNF therapy except
1. Infection 2. Tuberculosis3. Hepatits B4. Lymphoma
The TB incidence rate in Taiwan is around
1. 10-24 /100,000 population2. 24-49/ 100,000 population 3. 50-100/100,000 population4. 100-299/100,000 population
Taiwan 66.7
Hong Kong 77
China 102
Phillipines 296
臺灣仍是結核病中度流行區結核病例報告率為西元 2004年之每十萬人 74例至2007每十萬人 85例 ; 在 2010年則降為每十萬人57例
Malaysia 106
S. Korea 87
N. Korea 178
Singapore 41 Japan 31
Australia 5.7
Guam 60
Thailand 142
Indonesia 285
USA 4.6 Canada 5.5
UK 12 S. Africa 536
Vietnam 178Every 100,000 people
Data From WHO: World TB Report 2005
Which is the correct statement regarding screen tests TST (tuberculin skin test) and IGRA (interferon-r release assay) for latent TB infection ?
1. TST is of better sensitivity than IGRA2. IGRA is of better sensitivity than TST3. TST is of better specificity than IGRA4. IGRA is of better specificity than TST
A recent meta-analysis: QFT assay has high specificity (96%), whereas TST has low specificity in BCG-vaccinated people (Ann
Intern Med 2008;149:177-84 )
TST
QFT
SpecificitySensitivity
Which of the following treatment carries the highest risk of HBV reactivation
1. Methotrexate2. Steroid3. Anti-TNF plus steroid4. Rituximab plus steroid
Hepatitis flares in HBsAg (-) NHL patients Hui CK et al:
Gastroenterology 2006; 131: 59-68
• A retrospective study of 244 HBsAg (-) lymphoma patients
• 8 patients developed hepatitis (median follow-up 12.4 months)
• 3 fulminant hepatitis
6/49 12%
Which of the following antiviral drugs carry the higher risk of emergence of HBV mutant variant?
1. Lamivudine2. Adefovir3. Entecavir4. Telbivudine
24
Cumulative Incidence of HBV Resistance
J Hepatol 2009; 50: 227–42.
lamivudine adefovir entecavir telbivudine tenofovir