What’s new in FlyBase (in its 25th year)€¦ · What’s new in FlyBase (in its 25th year)...
Transcript of What’s new in FlyBase (in its 25th year)€¦ · What’s new in FlyBase (in its 25th year)...
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What’s new in FlyBase (in its 25th year)
Steven Marygold
• JBrowse • Gene Snapshots • Gene Groups • Orthologs
• Human Disease Models • Gene2Function • Community interactions • New website
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JBrowse
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Gene Snapshots
Epidermalgrowthfactorreceptor(Egfr)isthetransmembranetyrosinekinasereceptorforsignalingligandsintheTGFαfamily(grk,spi,vn,andKrn),whichuAlisestheintracellularMAPkinasepathway.EgfrrolesincludegrowthregulaAon,cellsurvivalanddevelopmentalpaFerning.
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Gene Groups
‘Gene Groups’ encompass: • gene products sharing molecular function (kinases, tRNAs…) • gene families (actins, odorant receptors…) • subunits of complexes (ribosome, spliceosome…)
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Gene Group Reports
Linkstoexternalresources
ManuallywriFendescripAonofgroup,withnotes
Listofmembers,withexportto:1.Hit-list2.BatchDownload3.Orthologstool
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Orthology search tool
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Orthology search results
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Human Disease Model data
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Human Disease Model Reports
Linkstorelateddiseases/flymodels
ManuallywriFensummaryofdiseaseandmodel
Listofflystocksusedinmodel
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www.gene2function.org
FlyGene
Mouse/RatGene
FrogGene
FishGene
YeastGene
WormGene
HumanGene
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New hit-lists
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Revised Gene Reports
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Community Interactions
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Further information
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Acknowledgements & funding FB-Indiana (USA): Thomas Kaufman Brian Calvi Bryon Czoch Josh Goodman Gary Grumbling Victor Strelets Jim Thurmond
FB-Harvard (USA): Norbert Perrimon Julie Agapite Kris Broll Lynn Crosby Gil dos Santos David Emmert L. Sian Gramates Kathleen Falls Beverley Matthews Susan Russo Gelbart Christopher Tabone Pinglei Zhou Mark Zytkovicz
FB-Cambridge (UK): Nick Brown Giulia Antonazzo Helen Attrill Silvie Fexova Phani Garapati Alex Holmes Tamsin Jones Aoife Larkin Steven Marygold Gillian Millburn Alix Rey Vitor Trovisco Pepe Urbano
FB-New Mexico (USA): Richard Cripps Maggie Werner-Washburne Phillip Baker
FlyBase Funding: NHGRI at the U.S. National Institutes of Health (U41HG000739)
British Medical Research Council (G1000968)
DRSC/TRiP: Claire Hu, Aram Comjean, Stephanie Mohr