WELCOME [w5.siemens.com] · SIPAT as enable for Continuous Manufacturing – First FDA approved...

WELCOME

Middle East Press Delegation:

Digitalization of the

Process Industries

siemens.com Restricted @ Siemens AG 2018

Siemens AG 2018

September 2018 Process Industries and Drives

siemens.com/processautomation Restricted © Siemens AG 2018

Digitalization and automation

of the process industries Bernhard Kienlein

Head of Process Industries and Drives Division, Siemens CEE

Middle East Press Delegation Vienna, September 13th, 2018

Siemens AG 2018


We serve process industries with

digitalization, automation, electrification and more

XHQ Operations

Intelligence

SIMIT

simulation

COMOS

DCS, HMI and

Automation Systems

Panels

Industrial Commu-

nication and Identification

Analyzer Digital and Life-

cycle Services

Pressure /

Temperature

transmitters

Flow metering

Digitalization Automation

MOM/MES

Weighing

Positioner

Product Lifecycle

Management

Level metering

and more HV/MV/LV

switchgears

Motor control

centers

Electrification

Transformers

Motors, Drives

and Starters

Energy

Management

Gas-/Steam-

turbines

SILYZER

Siemens AG 2018


We leverage our industry know-how rooted in electrification

and automation as a differentiator for digitalization

Digitalization

Automation

Electrification

Siemens Software

Digital Services

Digital

Expertise

Water

and WW

Pharma Chemical

Glass

and Solar

Oil and

Gas

Minerals

Fiber

Marine

1 The cloud-based, open IoT operating system

Digital enhanced Electrification and

Automation

MindSphere1

Siemens AG 2018


With our support, process industry companies can meet

essential market and customer requirements

New business models

Flexibility Efficiency Speed Quality

Security

Siemens AG 2018


“How can I profitably produce and release small batches?”

How can we achieve personalized, safe but affordable

medicine? Digitalization in the pharmaceutical industry

Pharma

Pharmaceutical Industry

Siemens AG 2018

September 2018 Process Industries and Drives Page 7

Pharma Challenges

Pharmaceutical

Manufacturing

Challenges >500 pages

of paper batch documentation

>25% cost of quality in drug manufacture

600% increase in FDA warning letters

Siemens AG 2018


Personalized Medicine is transforming Healthcare & Pharma

Industry Trends

Dri

vers

: P

ers

on

aliz

ed

Me

dic

ine

,

D

igit

aliz

atio

n &

Ind

ust

ry 4

.0

Tod

ay

Tom

orr

ow

Pharma

Large Scale Production

• Patent Protection and large Markets

balance long Development Times and fail

Batches.

Individualized Production

• Platform Processes and Integrated

Production Control Strategies are key

Enabler for individualized Manufacturing.

1 Spear et al. 2001 2 www.clinical.trials.gov queried for Trials with Keywords individualized and/or personalized in 11/16

“One does not fit all”

• Today’s Drugs are ineffective in up to 50%

and more of the Patients1.

Healthcare

“Personalized Medicine”

• Individualized Treatment tailored to the

Patient’s Molecular Profile.

Market Adoption

2000

1995

2005

2010

26

2

0

1756

2612 2016

• The Number of registered

clinical Trials in personalized /

individualized Medicine2 is

exponentially increasing and

new Products are expected to

enter and transform the Market.

• Individualized Medicine/Manufacturing

Solutions need to enable flexible and

fully controlled, small-scale Processes

as part of a holistic Product Life Cycle

Management from Patient to Patient.

Trends are translating to

Markets

2020

Siemens AG 2018


What digitalization means to pharmaceutical manufacturing

Providing digital solutions along entire value chain

Flexibility

• Personalized medicine

• Data integrity from lab

to patient

Time to market

• From idea to production

• Continuous Manufacturing

• Smart Modular Standards

Quality/Regulation

• Right first time production

• Data integrity

• Data consistency

Efficiency

• Operational excellence

• Resources and COGS

• International collaboration

Integrated Operations

Integrated Engineering

Product

design

Production

planning

Production

engineering

Production

execution Service

Siemens AG 2018


Integrated Engineering

Paperless (eBR)

Digital Twin

Cloud & Fog Personalized Medicine Continuous (PAT)

Process & Plant Simulation

MindSphere

10 01 01 11

01 00 11 10

10 01 01 11

10 01 01 11

10 01 01 00

01 00 11 10

10 01 01 11

10 01 01 11

10 01 01 11

01 00

10 01

10 01 01 11 01

10 01 01 00

01 00 11 10 01 00 11

10 01 01 11

10 01 01 11 00 10

Smart Bio-Production

Focused on bringing innovation to the pharmaceutical

industry through initiatives

Siemens AG 2018


SIPAT as enable for Continuous Manufacturing –

First FDA approved change1 from traditional batch to continuous

FDA – Food Drug Administration; NIR – Near Infrared; PAT – Process Analytical Technology;

1 Yu, Lawrence, Ph.D. “Continuous Manufacturing Has a Strong Impact on Drug Quality.” FDA Voice.12 Apr. 2016.

NIR

Blender

Reject

Coating

solution

End

product

Raw

Material 1 Raw

Material 2

Raw

Material 3

Raw

Material 4

Tablet Press

Coating pan

Feeders

NIR

Innovative partnerships to trans-

form manufacturing operations

• Transforming assembled

unit operations to continuous

• PAT Enabled central control system • Continuous quality verification

• Real-time release testing

• Smaller footprint and reduced waste

• Improved yield and labor cost savings

Siemens AG 2018


BioNTech, Germany

A digital plant for personalized vaccines

Advanced paperless manufacturing

• Central access point for data

• Enable fast scale up

• Eliminate paper-based batch

reports and release by exception

• Intelligent guidance, planning

and scheduling

Customer benefits

• Access your data centrally

• Eliminate paper-based reports

• Time-to-Market

Siemens AG 2018


Living Lab Process Industries in Vienna Integrated Siemens portfolio based on fermentation process

siemens.at Restricted © Siemens AG 2018

Digitizing Oil and Gas Optimizing oil production by applying

digital technologies

Siemens AG 2018

September 2018 Seite 15 Helmut Schnabl / RC-AT PD SLN

Oil & Gas is a more than 150 years old industry …

About 40 percent of

global crude oil and

natural gas production

comes from fields that

have been in operation

for more than 25 years.

About 175 fields have

been producing for

more than 100 years.

Drake Well, 1859, Cherrytree Township, USA

Siemens AG 2018


Mature fields are essential to supply global oil demand

Siemens AG 2018


Artifial lift systems are essential to keep production high

in mature oilfields

More than 94% of the wells globally will

require artificial lifts during their life cycle

Siemens AG 2018


SIWELL is Siemens‘ next generation digital solution to automate

and optimize artificial lift systems

Reservoir

Performance

Management

Optimization of

energy consumption

Learning Systems

Production Planning

Artificial Intelligence

SRP

ESP

PCP

Gaslift

Nat. Flow

WIMAX

Monitoring

Alarms

Software upgrades

Central shutdown

Control Room / SCADA

IoT Platform and O&G Applications

Oil & Gas Applications

http://www.google.at/url?sa=i&rct=j&q=&esrc=s&source=imgres&cd=&cad=rja&uact=8&ved=0ahUKEwjxkIj-ocfTAhVCDCwKHftpBdkQjRwIBw&url=http://www.kongresskultur.com/service/kostenloses-wlan/&psig=AFQjCNGDIoLcXv2dEr_p_E0yg3lNLA6avA&ust=1493472827139406

http://www.google.at/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwjXsZeL7d_TAhUNSJoKHQL5BcwQjRwIBw&url=http://smartfactory.ie/product/simatic-iot2040/&psig=AFQjCNGRAAnI274MHUxwQ6N5WcqIjmo2-Q&ust=1494317616884918





http://www.google.at/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwjsxLq5osfTAhWBhywKHTgwD4MQjRwIBw&url=http://www.istockphoto.com/search/more-like-this/165793495?excludenudity=true&mediatype=illustration&sort=best&psig=AFQjCNHlUlEIZYW_Oozwcbng6juRGX0mVg&ust=1493472904434323

http://www.google.at/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwimx7WSrMfTAhWC2ywKHRlUD_QQjRwIBw&url=http://www.ebrahma.com/2015/08/an-introduction-to-lte/&psig=AFQjCNF0fjlv_ymk_ByMj3e0iqfkiVFdPw&ust=1493475550913283

https://www.google.at/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwj0vOSyp8fTAhVG2CwKHZV1DPEQjRwIBw&url=https://mall.industry.siemens.com/mall/de/WW/Catalog/Product/?mlfb=6AV7880-0....-...2&psig=AFQjCNFexoG7nd_YruWoy0I9jTRz3tiiLw&ust=1493474277551828

Siemens AG 2018


Example: Edge analytics and smart automation optimize pumps

in the field

Smart Motor Control Motor Management

Safety/automation

functionality

Power measurement

Power supply:

Complete equipment for power

supply

1

4

2

3 Connectivity

WLan, 3G/4G, LoRa,WIMAX

Industrial Tablet

Industrial IoT Platform

SCADA

IoT gateway / Edge Analytics Industrial Intel®-based gateway

Soft sensing

Alarming

Smart Motor Control Motor Management

Safety/automation

functionality

Power measurement

Power supply:

Complete equipment for power

supply

1

4

2

3 Connectivity

WLan, 3G/4G, LoRa,WIMAX

Industrial Tablet

Industrial IoT Platform

SCADA

IoT gateway / Edge Analytics Industrial Intel®-based gateway

Soft sensing

Alarming

http://www.google.at/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwiG6P_hubzRAhVBpiwKHRG4DPEQjRwIBw&url=http://w3.siemens.com/mcms/pc-based-automation/en/industrial-pc/pages/default.aspx&bvm=bv.143423383,bs.1,d.bGg&psig=AFQjCNE8Yr1EvnGlV37gcNv-QZwJCvhwmw&ust=1484305146275966

http://www.google.at/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwjOhI_lt7zRAhWG3iwKHdoCAdkQjRwIBw&url=http://www.provendor.fi/index.php?page=siemenssimocode&psig=AFQjCNEwy4lVBAsdNmW2n1QQ7pD65gQ8-Q&ust=1484304629175907

http://www.google.at/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwiG6P_hubzRAhVBpiwKHRG4DPEQjRwIBw&url=http://w3.siemens.com/mcms/pc-based-automation/en/industrial-pc/pages/default.aspx&bvm=bv.143423383,bs.1,d.bGg&psig=AFQjCNE8Yr1EvnGlV37gcNv-QZwJCvhwmw&ust=1484305146275966

Siemens AG 2018


Example: Artificial intelligence in the cloud predicts failure of ESP

pumps days before they would happen

P2

P1

P3

E

Deep Learning

Neural Networks

Statistical Models

Failu

re

Ala

rm

Significant Anomaly Level

Prediction

Siemens AG 2018


Digitalization will transform the oil & gas industry

Automation, interaction and informed decisions based on data, digital twins and

artifical intelligence will make the competitive difference in O&G

Siemens AG 2018


Helmut Schnabl

Siemens AG Österreich

Phone: +43 664 8855 7243

E-mail: [email protected]

mailto:[email protected]

WELCOME [w5.siemens.com] · SIPAT as enable for Continuous Manufacturing – First FDA approved...

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