Welcome to Prof. Woo Lee’s Lab
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Sponsors Welcome to Prof. Woo Lee’s Lab Research & Entrepreneurship Day 2008 Nanomaterial Self-Assembly 1 m Cell- Biomaterial Interactions 100 m Microfluidic s & Microreactor s Nano-Micro-Bio Themes 2 m Tool Box 1 m Alcohol Nanoparticle s in Aqueous Droplet Self-Assembled Microspheres Time Diffusi on (NH 4 ) 2 SO 4 (aq) Oil BaCl 2 (aq) BaSO 4 Nanoparticl es Micromixi ng Emulsion Nucleation Nanoparticle Production Confined Self-Assembly Layer-by-Layer Self-Assembly Soft Lithography 2 m Negatively Charged Particles Positively Charged Polyelectrolytes + + + + + + + + - - - - - - - - - - + + + + + + + + - - - - - - - - - - + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Microfluidic Device Fabrication and Imaging S. epidermidis Cells Osteoblast Cells Projects • Application : On-demand chemical synthesis using micro-structured reactors • Goal : Develop a catalyst coating process to infiltrate and immobilize commercially available catalyst particles • Team : Dr. H. Qiu, Prof. A. Lawal • Funding : DOE, NJCST Catalyst Infiltration & Immobilization Substrate Yb 2 O 3 SiO 2 Particle Assembly Viscous/Reactive Sintering Yb 2 SiO 5 Substrate • Application : Next-generation gas turbine components above 1300˚C • Goal : Develop a new Yb 2 SiO 5 coating process for complex shape components • Team : Dr. Y.-F. Su • Funding : ONR High-Temperature Ceramic Coating ~10 m RDX+Polymer Microsphere ~100 nm RDX Nanocrysta ls Polymer Coating Bullet Hole “Insensitive 155 Projectile” • Application : RDX nanocrystals for insensitive munitions • Goal : Develop a manufacturing process for producing and coating RDX nanocrystals with reduced safety and health concerns • Team : Dr. Greenberg, Dr. R. Halder, Dr. H. Qiu, Prof. Koven, Prof. Libera from Stevens and V. Stepanov, Dr. P. Anderson, and A. DiStasio from U.S. Army • Funding : ARDEC Nano-Energetic Materials Physiological Framework of Microenvironment ECM Protein S. epidermidis Therapeutic Host Defense Osteoblast Biomaterial Device Functions • Microfluidic Multiplexing • Nontransparent Biomaterial • Time-lapsed Imaging • Application : Predictable in vitro infection model for biomedical devices • Goal : Image cell interactions with clinically relevant biomaterial under controlled microenvironment • Team : J.H. Lee, A. Ihnen, T. Boyd (Technogenesis Scholar), Prof. Wang, Prof. Libera • Funding : NSF-NIRT Subgroup Bacteria-Eukaryotic Cell-Biomaterial Interactions 10 m 10 nm New Jersey Center for MicroChemical Systems 2008 ChE Senior Design: Fast-Acting Ibuprofen D. Kandl, M. Abdul-Adziz, M. Muchnik, I. Handel Flow Nanostructured Surfaces Engineered Microenvironment New Nanoscale Materials and Phenomena Microstructur ed Devices Systems (“Good”) Engineering Chemical and Biological Systems of Future DARPA $12M Stevens-led teams since 2002 with partners & sponsors
description
Physiological Framework of Microenvironment. Emulsion. Polymer Coating. 1 m m. ECM Protein. Therapeutic Host Defense. ~10 m m RDX+Polymer Microsphere. Osteoblast. S. epidermidis. Yb 2 SiO 5. Substrate. Biomaterial. ~100 nm RDX Nanocrystals. Osteoblast Cells. - - - - -. - PowerPoint PPT Presentation
Transcript of Welcome to Prof. Woo Lee’s Lab
SponsorsSponsors
Welcome to Prof. Woo Lee’s LabResearch & Entrepreneurship Day
2008
Nanomaterial Self-Assembly
1 m
Cell-Biomaterial Interactions
100 m
Microfluidics & Microreactors
Nano-Micro-Bio ThemesNano-Micro-Bio Themes
2 m
Tool BoxTool Box
1 mAlcohol
Nanoparticles in Aqueous Droplet
Self-Assembled Microspheres
TimeDiffusion
(NH4)2SO4 (aq)
Oil
BaCl2 (aq)
BaSO4
Nanoparticles
Micromixing
Emulsion
Nucleation
NanoparticleProduction
Confined Self-Assembly
Layer-by-Layer Self-Assembly
Soft Lithography
2 m
Negatively Charged Particles
Positively Charged Polyelectrolytes
+ + + ++ + + +- - - - -- - - - -+ + + ++ + + +- - - - -- - - - -+ + + ++ + + +
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-- -- -- -- -- -- --+ + + ++ + + +
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+ + + ++ + + +
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Microfluidic Device Fabrication and Imaging
S. epidermidisCells
Osteoblast Cells
ProjectsProjects
• Application: On-demand chemical synthesis using micro-structured reactors
• Goal: Develop a catalyst coating process to infiltrate and immobilize commercially available catalyst particles
• Team: Dr. H. Qiu, Prof. A. Lawal• Funding: DOE, NJCST
Catalyst Infiltration & Immobilization
Substrate
Yb2O3
SiO2
ParticleAssembly
Viscous/ReactiveSintering
Yb2SiO5
Substrate
• Application: Next-generation gas turbine components above 1300˚C
• Goal: Develop a new Yb2SiO5 coating process for complex shape components
• Team: Dr. Y.-F. Su• Funding: ONR
High-Temperature Ceramic Coating
~10 mRDX+PolymerMicrosphere
~100 nmRDX
Nanocrystals
PolymerCoating
Bullet Hole
“Insensitive 155 Projectile”
• Application: RDX nanocrystals for insensitive munitions
• Goal: Develop a manufacturing process for producing and coating RDX nanocrystals with reduced safety and health concerns
• Team: Dr. Greenberg, Dr. R. Halder, Dr. H. Qiu, Prof. Koven, Prof. Libera from Stevens and V. Stepanov, Dr. P. Anderson, and A. DiStasio from U.S. Army
• Funding: ARDEC
Nano-Energetic Materials
Physiological Framework of Microenvironment
ECM Protein
S. epidermidis
Therapeutic
Host DefenseOsteoblast
Biomaterial
Device Functions• Microfluidic Multiplexing• Nontransparent Biomaterial• Time-lapsed Imaging
• Application: Predictable in vitro infection model for biomedical devices
• Goal: Image cell interactions with clinically relevant biomaterial under controlled microenvironment
• Team: J.H. Lee, A. Ihnen, T. Boyd (Technogenesis Scholar), Prof. Wang, Prof. Libera
• Funding: NSF-NIRT Subgroup
Bacteria-Eukaryotic Cell-Biomaterial Interactions
10 m
10 nm
New Jersey Center for MicroChemical SystemsNew Jersey Center for
MicroChemical Systems
2008 ChE Senior Design:Fast-Acting Ibuprofen
D. Kandl, M. Abdul-Adziz, M. Muchnik, I. Handel
Flow
Nanostructured Surfaces
Engineered Microenvironment
New NanoscaleMaterials and Phenomena
MicrostructuredDevices
Systems (“Good”)Engineering
Chemical and BiologicalSystems of Future
DARPA
$12M Stevens-led teams since 2002 with partners & sponsors
