Welcome toMolecular Biology Through Discovery

Tuesday, 4 September 2012

Wrinch: Structure of Chromosomes / Protein

Welcome toMolecular Biology Through Discovery

Tuesday, 4 September 2012

Wrinch: Structure of Chromosomes / Protein

What do we talk about?

Determined by Questionnaires

Your QuestionsJust to make sure I'm clear we're not submitting the SQ questions that we answered

for review correct?

we don't have to send in all the answers to the question

on each reading right? Just the questions set on the

problem sets?

Remind me about what we were suppose to do

with the group assignment.  

Wrinch (1936) – What is a Gene?

Explaining what did they think back in 1936 compared

to now day's thoughts

What are genes?... There is no consensus of opinion amongst geneticists as to what the genes are – whether they are real or purely fictitious – because at the level at which the genetic experiments lie, it does not make the slightest difference…

Thomas Morgan Nobel Lecture (1934)

Wrinch (1936) – What is a Gene?

Wrinch (1936) – What is a Gene?

Morgan T (1934) Nobel Lecture

Drosophilachromosome

The constancy of position of genes with respect to other genes in linear order in the chromosomes is deducible, both from genetic evidence and from cytological observations.

Wrinch (1936) – What is a Gene?

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Could we perhaps go over a little more of how she visualized genes in her chromosome micelle model?

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Wrinch (1936) – What is a Gene?

Dorothy Wrinch

Protein

…structural levels of proteins, for some reason I was under the

impression that every protein consisted of all of

the structures

1. Enumeration

2. Local interaction

3. Distant interaction

4. Interaction between subunits

Primary Structure

ProteinDifferent levels of protein structure

1. Enumeration Primary Structure

2. Local interaction Secondary Structure

3. Distant interaction

4. Interaction between subunits

ProteinDifferent levels of protein structure

1. Enumeration Primary Structure

2. Local interaction Secondary Structure

3. Distant interaction Tertiary Structure

4. Interaction between subunits

ProteinDifferent levels of protein structure

1. Enumeration Primary Structure

2. Local interaction Secondary Structure

3. Distant interaction Tertiary Structure

4. Interaction between subunits

Quaternary Structure

ProteinDifferent levels of protein structure

ProteinDifferent levels of protein structure

hemoglobin myoglobin

Compare

Protein

…structural levels of proteins, for some reason I was under the

impression that every protein consisted of all of

the structures

Primary Secondary Tertiary Quaternaryper definition per definition optionaloptional

Annotation

Critique annotationT4p018T4p039T4p042T4p120

How to Annotate Genes

Coming Attractions

Coming Attractions

Coming Attractions

Coming Attractions

Coming Attractions

I think the most challenging part of this process is finding evidence

the most helpful thing to go over in class would be how to find evidence to justify an annotation.

How to Annotate Genes

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

How does protein get inside?

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

Goodbye fromMolecular Biology Through Discovery

Tuesday, 4 September 2012