Welcome to “Building STRENGTH”...
Transcript of Welcome to “Building STRENGTH”...
Welcome to “Building STRENGTH”
Webinars!
Hosted by:Dr David Ajibade & Cheri Plett
Special Guest: Gil Kaats, PhD
There is still an immense amount to be learned about health, but if what is at present known to a few
were part of the general knowledge, the average
expectation of life could probably be increased by about ten years
~ J.B.S. Haldane
Gil Kaats, PhDChairman and CEO,
Integrative Health Technologies, IncThursday, September
3rd:Optimizing
Bone Health and Body Composition:
How Changes in Bone, Lean and Fat Can
Profoundly Contribute to
Optimizing Health and Wellness
Copyright © 2009 by Gilbert R. Kaats, PhD
TABLE OF CONTENTS FOR SLIDESThis power point presentation is copyrighted and cannot be reproduced in any form beyond the initial permission
granted to Building Strength Webinars 9/03/09 attendees
Restructuring Body Composition: How the kind, not amount, of weight lost or gained defines the
pathway to optimal health
To obtaining testing requisitions and participate in on-going clinical trials, contact Integrative Health Technologies, Inc. at
1-210.824.4200
For a copy of the book, pedometer, and wholesale prices for the AlgaeCal Bone Health supplement, contact HealthTech Products, LLC. 210.274.6193
.
Copyright © 2009 by Gilbert R. Kaats, PhD
Title Slide
This book is available for purchase from: HealthTech Products, LLC., 210.274.6193
The Glyconutritional PlantPolysaccharide Longitudinal
Trials Edition
Copyright © 2009 by Gilbert R. Kaats, PhD
TABLE OF CONTENTS FOR SLIDES
The Goal of this presentation is to support the Building Strength Webinar’s Mission of:
By presenting top quality educational presentations
each week, we hope to empower people with the
wisdom needed to make intelligent decisions about
how they use their own minds and bodies, and thus
live long, healthy and meaningful lives.
Copyright © 2009 by Gilbert R. Kaats, PhD
Integrative Health Technologies’ MissionA Public Company Trading as IHTI
Using the expertise of its Scientific Advisory Board, data from its 30-year longitudinal database of over 2,000,000 medical biomarkers, and its on-
site mobile testing capability, IHTI provides services to the healthcare and nutritional industries in three general areas:
1. Consulting, research and development and joint-venture with companies that lack the resources to conduct in-house R & D.
2. On-site corporate wellness programs that include the use of state-of-the-art measurements of quality of life, blood chemistries and body composition
(lean, bone & fat) using mobile DEXA testing technologies.
3. Independent clinical trials validating the safety and efficacy of health-enhancing products, technologies and dietary supplements.
Copyright © 2009 by Gilbert R. Kaats, PhD
Our Goal of This Presentation
1. Contribute to the webinar goals of providing you with information that will empower you to make intelligent decisions about your minds, bodies
and quality of life.
2. Recruit subjects for our clinical trials by having you purchase at research study prices cutting-edge tests that you make intelligent decisions about your health and wellness to increase the meaningfulness of your lives.
3. Have you purchase a copy of my “Restructuring Body Composition” that describes the results of our 14-year longitudinal trial and information that
is consistent with the webinar’s goals.
Copyright © 2009 by Gilbert R. Kaats, PhD
Gilbert R. Kaats, PhD, Principal Investigator
Dr. Kaats received his PhD in psychology from the Univ. of Colorado in 1969 while serving as an associate professor of psychology at the Air Force Academy.
He retired from the Air Force in 1974 after accumulating over 7,000 hoursas a navigator that included tours of duty in trans-global flights with
Military Air Lift Command, Air Sea Rescue, as a navigator for Air Force Two and a combat tour in the Viet Nam conflict. During his tour, he also aided in
the development, implementation and supervision of a variety of behavior modification programs that included programs for substance abuse, race
relations, and equal opportunity and treatment programs.
IHTIIHTI’’s studies have been conducted by teams of investigators froms studies have been conducted by teams of investigators fromHarvard University, Baylor College of Medicine, HarborHarvard University, Baylor College of Medicine, Harbor--UCLA Medical UCLA Medical
School, University of Texas Health Science Center, Georgetown USchool, University of Texas Health Science Center, Georgetown University,niversity,the University of California at San Diego, and the University of California at San Diego, and
the University of Texasthe University of Texas’’ Health Science Center in San Antonio. Health Science Center in San Antonio.
Dr. Kaats’ Curriculum Vitae can be found on www.ihtglobal.com
Copyright © 2009 by Gilbert R. Kaats, PhD
Dr. Kaats has been conducting clinical studies and R & D for over 30 years and is a Fellow of the American College of Nutrition
Appointed as Diplomate of Clinical Nutrition, Chairman of theDivision of Clinical Nutrition, and Executive Member of the
American Association of Integrative Medicine’s Advisory Board.
Holds memberships in:American Psychological Association,
American Psychological Society, American Federation for Medical Research,
Society for Clinical Densitometry, Christian Medical Foundation International, Inc.,
American Society of Bariatric Physicians (Associate Member), the Association for Clinical Research Professionals
Gilbert R. Kaats, PhD, Principal Investigator [cont.]
Investigators
Copyright © 2009 by Gilbert R. Kaats, PhD
Dr. Kaats received his PhD in research psychology from the Univ of Colorado in 1969 while serving as an associate professor of psychology at the Air ForceAcademy. He retired from the Air Force in 1974 after accumulating over7,000 hours as a navigator that included duty in trans-global flights with
Military Air Lift Command, Air Sea Rescue, as a navigator for Air Force Two, and a combat tour in Southeast Asia during the Viet Nam conflict.
During his Air Force career, he also aided in the development, implementation and supervision of a variety of behavior modification programs for substanceabuse, race relations, social action and equal opportunity and treatment.
Dr. Kaats’ Curriculum Vitae can be found on www.ihtglobal.com
Gilbert R. Kaats, PhD, Principal Investigator [cont.]Investigators
Copyright © 2009 by Gilbert R. Kaats, PhD
The Co-Investigators
Harry A. Preuss, M.D. Professor of Medicine, Georgetown UniversityFormer President of the American College of Nutrition
Joel Michalek, Ph.D. Co-chair Department of Statistics and Epidemiology, University of Texas Health Science Center at San Antonio
Harry A. Croft, M.D. Private Practice in Psychiatry, San Antonio, TXDistinguished Life Fellow of the American Psychiatric Association
Raul Bastarrachea, M.D. Department of Genetic and Metabolic Research, Southwest Foundation for Biomedical Research, San Antonio, TX
William Squires, Jr. Ph.D. Professor of Biology, Texas Lutheran University, Sequin, TX
Steven Van Camp, M.D. Cardiologist, University of California at Irvine, CAFormer President of the American College of Sports Medicine
Dennis Pullin, M.S. Chief Operating Officer, Washington General Hospital, Wash DC
Larry K. Parker, M.D. Obstetrician/Gynecologist, Angelton, TX
Samuel C. Keith, BBA CEO, Health & Medical Research, Inc., San Antonio, TX
Kristi L. Hobbs Spiritual Interventions and Nutritional Research in Developing Countries Alamo City Mercy Foundation, San Antonio, TX
Copyright © 2009 by Gilbert R. Kaats, PhD
PART 1-Research Goals
The National Institutes of Health’s Office of Dietary Supplements 2004-2009 Strategic Plan is:
“To Promote Quality Science in Dietary Supplement Research to validate of unique biomarkers of dietary supplement effects on known endpoints of…optimal health, and improved performance.” (pg 15]“Promoting Quality Science in Dietary Supplement Research, Education, and Communication:
A Strategic Plan for 2004-2009”, National Institutes of Health,2004.
Copyright © 2009 by Gilbert R. Kaats, PhD
U.S. Surgeon General’s Bone Health Report
• More than 2/3 of American adolescents are not receivingadequate bone-building nutrients for normal bone growth
• The absence of adequate nutrition during these critical bone-building years has placed America’s bone health in jeopardy
• About 20% of senior citizens who suffer a hip fracturedie within a year of the fracture.
• About 20% of individuals with a hip fracture end up in anursing home within a year
• Hip fractures account for 300,000 hospitalizations a year
• Direct care costs of bone fractures are $18 billion/yr
Copyright © 2009 by Gilbert R. Kaats, PhD
Meeting The Surgeon General’s “Call to Action”
To address this problem, the SG issued a “call to action” for the healthcare industry to “…get started by taking action today in homes, health care settings, and communities across our nation. Remember, you are never too old or too young to improve your bone health...through:
1. improved diets2. improved ‘health literacy’3. increased physical activity”
PART 1: Research Goals
Copyright © 2009 by Gilbert R. Kaats, PhD
Overview of the goals of the longitudinal trialsTo respond to the Surgeon General’s “call to action” by
examining the effect of participation in a bone health plan that provides the three fundamentals of the SG’s
“call” by providing for:
(1) improved diets by the use of: Glyconutritional supplements
(2) increased health literacy by publishing the:Glyconutritional Longitudinal Trials book
(3) increased physical activity through the use of aPedometer-based (“clicker”) program
Copyright © 2009 by Gilbert R. Kaats, PhD
Title Slide
All slides and page references are from the book:
This book is available for purchase from: HealthTech Products, LLC., 210.274.6193
The Glyconutritional PlantPolysaccharide Longitudinal
Trials Edition
Copyright © 2009 by Gilbert R. Kaats, PhD
Table of Contents
Ch 1: Structure/Function Versus Medical/Disease Claims
Ch 2: The Longitudinal Trials
Ch 3: DEXA Technology: Measuring Instead of Estimating
Ch 4: Lean and Fat: Pivotal Biomarkers of Optimal Health and Longevity
Ch 5: Bone Mineral Density: A Pivotal Biomarker of Bone Health
Ch 6: Maintaining Healthy Lipids and CRP Levels
Ch 7: The Effects of Glyconutritional Plant Polysaccharides on Quality of Life
Ch 8: The “Clicker”: What Gets Measured and Tracked, Gets Managed
Ch 9: The Glycemic Index and the Glycemic Load
Ch 10: Calories: Estimating and Balancing
Copyright © 2009 by Gilbert R. Kaats, PhD
Title Slide
Available for Purchase from: HealthTech Products, 210.274.6193
Overview of the Research Reported in the
Longitudinal Trials Book
It presents all data in four-color reader-friendly illustrations along with updated charts of the glycemic load of over 700 foods. It also includes complete copies of the 5 studies our independent research team published during the trials that are the basis of our conclusion that taking Mannatech’s glyconutritional plant polysaccharide supplements can:
(1) improve bone health by increasing bone mineral density, (2) aid in the reduction of excess body fat,(3) help maintain or increase lean (muscle) mass, (4) increase self-reported quality of life and (5) improve immune health as measured by C-reactive Protein (CRP).
Thus, these biomarkers provide evidence that taking glyconutritional supplements appear to facilitate improvements in immune health.” [pg ix]
Copyright © 2009 by Gilbert R. Kaats, PhD
Goals of the Longitudinal Trials
“To validate structure and function changes in biomarkers of wellness, optimal health, improved performance and quality of life that appear to be facilitated by the use of dietary supplements that include evidence-based diet and exercise plans.”
Copyright © 2009 by Gilbert R. Kaats, PhD
55 70 75 80 85 906560
The Green Zone:Years of Increased Vita lity
Intervention w ith the Optimal Health Plan
Average Person's Entry into the Disability Zone
Extended Entry After Following the Optimal
Health Plan
The Disability Zone"The point at which people lose their functional capacity and have to be cared for by other people or agencies."Adapted from Evans & Rosenberg's, "Biomarkers: The 10 Keys to Prolonging Vitality, " Simon & Schuster, NYC.
Age in Years:
The "Health Span" of the Average Person
The Disability Zone: The Research Model
Interventions to ImproveBody Composition
Extended EntryWith Enhanced
Body Composition
YYeeaarrss ooff IImmpprroovveedd QQuuaalliittyy ooff LLiiffee
Copyright © 2009 by Gilbert R. Kaats, PhD
What are structure/function claims?
Structure/Function claims describe the role of a nutrient or dietary ingredient intended to affect the structure or function in humans or that characterize the documented mechanism by which a nutrient or dietary ingredient acts to maintain such structure or function. However, they must not be disease claims that suggest the nutrient or ingredient can “cure, mitigate, treat, or prevent disease”.
Copyright © 2009 by Gilbert R. Kaats, PhD
Comparative Effectiveness Research (CER)Opportunities and Challenges for the Nutritional Industry
Gilbert R. Kaats, PhD, Harry G. Preuss, MD, & Robert B. Leckie, M.Eng., LL.BAccepted for publication in the: Journal of the American College of Nutrition
0.0%
0.5%
1.0%
1.5%
2.0%
P = 0.23Arms
Legs
Trunk
Ribs
Pelvis
Spine
Total
% of Annual Change in Bone Mineral Density for HIV Positive Patients
P = 0.77
P = 0.01P = 0.02
P = 0.22
P = 0.06
P = 0.01
Copyright © 2009 by Gilbert R. Kaats, PhD
Body Composition: Beyond Obesity, Osteoporosis and Osteopenia
Dysfunctional body composition Dysfunctional body composition is a powerful accelerator of overis a powerful accelerator of over
40 different diseases40 different diseasesAmerican Medical AssociationAmerican Medical Association’’ssNational Summit on Obesity, 2004National Summit on Obesity, 2004
3131 3030
44 55 66 77 88 99 1010
1515
14141313121211113322
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2020
23232424 222228282121
292932323333
3434
2626 25252727
3636
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Copyright © 2009 by Gilbert R. Kaats, PhD
CalleCalle, E. E. et al. N , E. E. et al. N EnglEngl J Med 2003;348:1625J Med 2003;348:1625--16381638
Excess Weight vs. Type of Cancer in Women
Copyright © 2009 by Gilbert R. Kaats, PhD
The Typical American’s Solution to Weight Gain
Copyright © 2009 by Gilbert R. Kaats, PhD
Achieve Goal Weight by Improving Body Composition
It is the kind, not the amount, of weight one loses that sets the pathway to optimal health. It is essential to establish a personalized healthy goal weight through the reduction of excess body fat while maintaining, or increasing, lean mass and bone density.
Copyright © 2009 by Gilbert R. Kaats, PhD
Excess Body Fat and Inflammation
One of the primary causes of undiagnosed inflammation is increased body fat. People tend to think of fat mass as inert. Unfortunately, stored fat is a very active source of inflammation. Therefore, the first line of defense against inflammation is reduction of excess fat.
Sears, Silent Inflammation, Nutraceuticals World, 2005: 8:38-45.
Copyright © 2009 by Gilbert R. Kaats, PhD
Measuring Body Fat and Lean—The DEXA Test “What gets measured, gets managed.”
Copyright © 2009 by Gilbert R. Kaats, PhD
When a 1 lb “failure” Masked a 7 lb Success
W eight Change
Fat Change
Lean Change
BCI
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
8
9
10
The scale w eight suggests a 1.0 lb negative treatm ent outcom e. But the w eight gain w as the result of a -3.0 lb loss of body fat and a gain of 4.0 lbs of lean m ass--both positive treatm ent outcom es. How ever, the BCI correctly depicts a +7.0 lb positive treatment outcom e correcting the distortion.
+ 1.0 lbs
+ 7.0 lbs
+ 4.0 lbs
- 3.0 lbs
Based on actual data Based on actual data derived from HMRC data base, August 2005derived from HMRC data base, August 2005
Copyright © 2009 by Gilbert R. Kaats, PhD
When a 2 lb “success” Masked a 10 lb Failure
Weight Change
Fat Change
Lean Change
BCI
-12
-11
-10
-9
-8
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
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The scale weight suggests a -2.0 lb positive treatment outcome. But the weight loss resulted from a - 4.0 lb increase on body fat and a decrease of - 6.0 lbs of lean mass--both negative treatment outcomes.
The BCI correctly depicts a -10.0 lb negative treatment outcome correcting the distortion.
- 2.0 lbs
- 10.0 lbs
- 6.0 lbs
+ 4.0 lbs
Based on actual dataBased on actual dataderived from HMRC data base, August 2005derived from HMRC data base, August 2005
Copyright © 2009 by Gilbert R. Kaats, PhD
Sarcopenic Obesity: Confluence of Two Epidemics“The two greatest epidemiological trends of our times are the aging of the population and the obesity epidemic. Each of these trends has important effects on body composition, morbidity, and mortality. Aging causes a progressive loss of muscle mass and strength, independent of any disease process, called sarcopenia. Sarcopenia is an important cause of frailty, disability, and loss of independence in the elderly, and recent estimates suggest that it costs the United States over $18 billion per year, a sum on par with the economic consequences of osteoporosis.”
Obesity ResearchObesity Research, 2004; 12:887, 2004; 12:887--888 & 913888 & 913--920.920.
Copyright © 2009 by Gilbert R. Kaats, PhD
The Impact of Sarcopenic Obesity in the Elderly
“Obesity has important functional implications in elderly persons because it worsens the age-related decline in physical function, which can lead to frailty and loss of independence”.Obesity Research, 2004; 12:887-888 & 913-920.
“Obesity may be the single greatest cause of disability in elderly persons….”Journal of the American Geriatric Society, 2002; 50:1802-1809.
“Obesity is associated with increased rates of nursing home admissions…”Obesity Research, 2002; 10:816-823.
Copyright © 2009 by Gilbert R. Kaats, PhD
The % of Women Unable to Lift Over 10 lbs (by age group)
65%
40%45%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Ages65-74
Ages75-84
Percentage of Women Unable to Lift Over 10 Pounds
Ages55-64
Copyright © 2009 by Gilbert R. Kaats, PhD
Crisis in Bone Health:
The US Surgeon General’s
Call to Action
Copyright © 2009 by Gilbert R. Kaats, PhD
Improving “Health Literacy” by Personal Feedback of Changes in Bone Density -
The DEXA Test [Chapter 5]“What gets measured, gets managed.”
Copyright © 2009 by Gilbert R. Kaats, PhD
Percentage of women unable to lift over 10 lbs
0.001
-0.006
-0.004
-0.002
0.000
0.002
0.004
0.006
0.008
0.010
0.012
0.014
0.016
Figure 1. A Meta Analysis Comparing Expected Changes in Bone Mineral Density With Historical Data From Five Different Groups: (1) A Control In Which Subjects Were Free to
Follow Any Program of Their Own Choosing, (2) Dietary Supplements, (3) Placebo, (4) Fitness Clubs and (5) Glyconutrients
N=191 N=127N=239 N=196N=131
Dietary Supplements
ExpectedChange
Placebo
Fitness Clubs
Control
Glyconutrients
-0.003
+0.001+0.002
+0.003+0.004
+0.014
Bon
e M
iner
al D
ensi
ty (
BM
D) g
/cm2
Copyright © 2009 by Gilbert R. Kaats, PhD
Percentage of women unable to lift over 10 lbs
-0.016
-0.014
-0.012
-0.010
-0.008
-0.006
-0.004
-0.002
0.000
0.002
0.004
0.006
0.008
0.010
Figure 2. A Comparison of Changes in Bone Mineral Density Between a Placebo Group, a Group Taking Different Dietary Supplements and a Group Taking Glyconutrients Using a
Randomized Placebo-Controlled Double-Blinded Protocol
N=12
N=10
N=54
ExpectedChange Placebo
Dietary Supplements
Glyconutrients
+0.008
-0.003 -0.013 -0.003
Copyright © 2009 by Gilbert R. Kaats, PhD
Percentage of women unable to lift over 10 lbs
A Source-data Derived* Meta Analysis of the Effects of a Plant Polysaccharide Supplement on Bone Mineral Densitya
Gilbert R. Kaats, PhD, Samuel C. Keith and Patti L. Keith Health and Medical Research Center, San Antonio, Texas
Published in The Original Internist
Publication Update
Copyright © 2009 by Gilbert R. Kaats, PhD
Percentage of women unable to lift over 10 lbs
-0.7%
2.2%
3.1%
3.7%
4.4%
-1.0%
0.5%
2.0%
3.5%
5.0%
Ann
ualiz
ed %
BM
D C
hang
es
Comparison of Annualized Changes in Bone Mineral Density in Different Groups of Highly Compliant Subjects Following the AlgaeCal Bone-Health Plan With and Without Plant Polysaccharide Glyconutrients (Glycos)
Expected Change
`
Initial AlgaeCal Formula
Final AlgaeCal Formula
Final AlgaeCal Formula
and Glycos
Final AlgaeCal Formula
and Glycos
1
2 3 4 5
1. Expected change in BMD without any intervention for subjects of this age and gender 2. Changes in BMD after taking the initial AlgaeCal formula3. Changes in BMD after taking the final (and current) AlgaeCal formula 4. Changes in BMD after taking the final (and current) AlgaeCal formula with Glyconutrients5. Changes in BMD from "Expected" after taking the final AlgaeCal formula with Glyconutrients
Publication Update
Copyright © 2009 by Gilbert R. Kaats, PhD
Informed Consent FormInformed Consent Form
How to obtain the blood chemistry test for $100(valued at $436)How to obtain a blood test requisition
Copyright © 2009 by Gilbert R. Kaats, PhD
Measuring and Tracking Systemic Changes in Blood Chemistries
Copyright © 2009 by Gilbert R. Kaats, PhD
•Triglycerides
•Cholesterol
•HDL-Cholesterol
•LDL-Cholesterol
•CHOL/HDLC Ratio
•Glucose
•Urea Nitrogen (Bun)
•Creatinine
•eGFR
•Bun/Creatinine Ratio
•Sodium
•Potassium
•Chloride
•Carbon Dioxide
•Calcium
•Protein
•Albumin
•Globulin
•Alb/Glob Ratio
•Bilirubin, Total
•Alkaline Phosphatase
•AST (SGOT)
•ALT (SGPT)
•White Blood Cells
•Red Blood Cells
•Hemoglobin
•Hematocrit
•MCV
•MCH
•MCHC
44-item Blood Chemistry TestIncludes Thyroid Stimulating Hormone and Cardio C-Reactive Protein
•RDW
•Platelet Count
•Absolute Neutrophils
•Absolute Lymphocytes
•Absolute Monocytes
•Absolute Eosinophils
•Absolute Basophils
•Neutrophils
•Lymphocytes
•Monocytes
•Eosinophils
•Basophils
•Cardio CRP
•TSH
“What gets measured, gets managed.”
Copyright © 2009 by Gilbert R. Kaats, PhD
Cardio C-Reactive Protein - Beyond Cholesterol
“50% of heart attacks occur in people with normal cholesterol levels”- Cardio CRP improves prediction
Copyright © 2009 by Gilbert R. Kaats, PhD
Predictive Power of Cardio CRP & Other Blood Tests
0.0
1.0
2.0
3.0
4.0
5.0
C-reactive Protein
LDLCholesterol
Total/HDLRatio
Homocysteine Total Cholesterol
HDLCholesterol
Copyright © 2009 by Gilbert R. Kaats, PhD
The Importance of Testing Blood Levels of Vitamin D
Blood Levels of Circulating Vitamin D may be the most powerful predictors of wellness and immune health. You can now take this test for $270 or $126 if we
can use your data in our longitudinal trials. To enroll, call 210.824.4200 Beginning on page 129 of the Longitudinal Trials book, we reported the results of an exploding amount of research on the relationship blood levels of Vitamin D (25-hydroxy vitamin D) and wellness and immune health.
In general, the HIGHER your blood 25-h Vitamin D the LESS LIKELY you are to1:
• fracture bones • lose muscle strength with age • become diabetic • develop multiple sclerosis • suffer from premenstrual syndrome (PMS) • develop gum disease • develop heart disease • suffer from infections • contract autoimmune diseases • develop Alzheimer’s disease • develop Parkinson’s disease • develop breast, colon, prostrate cancer • suffer from schizophrenia and depression • become obese • suffer from gastrointestinal disorders
Increasing Vitamin D blood levels. In spite of its ability to increase 25-h Vitamin D levels, “…FDA recommendations for daily supplementation of Vitamin D3 may be woefully inadequate”, particularly in view of the findings that “One billion people worldwide appear to have vitamin D deficiency”, a deficiency that was found in people of all ages - infants, toddlers, adolescents, pregnant and lactating women, the elderly, and people with limited exposure to thesun. A number of studies have shown that Vitamin D blood levels can be increased by taking Vitamin D3 supplements and increasing exposure to sunlight. Research suggests that it is virtually impossible to increase Vitamin D3 levels through diet alone. For Vitamin D3supplements and additional information on Vitamin D, contact Julie Marshall of HealthTech Products, LLC. @ 210-274-6193.
Copyright © 2009 by Gilbert R. Kaats, PhD
Percentage of women unable to lift over 10 lbs
How much Vitamin D3 Should I Take? The answer depends upon how much D3 you are now taking, how much you are getting from food, how much sunlight you typically get, and how your body metabolizes that D3. However, you should first start with measuring your 25-Hydroxyvitamin D ng/mL blood level to determine your current level:
Severely deficient = 0 to 15 Mildly deficient = 15 to 32 Optimal levels = 32 to 100 Potential toxicity = greater than 100
Other studies suggest that even 250-750 nmol/L would not be toxic. If you don’t get the measurement, virtually no studies suggest taking 2,000 IU a day is toxic, and many suggest that taking up to 10,000 IU of vitamin D3 a day may be safe. It is not unusual to have physicians prescribe 50,000 IU 3 times a week for up to 3 months.
Copyright © 2009 by Gilbert R. Kaats, PhD
Glyconutrients and Vitamin D blood levels. Most tissues and cells in the body have a vitaminD receptor that regulates cell growth and acts as a cell growth modulator and could be directly involved in inter-cellular communications. In view of the relationship of glyconutrients tocellular communication, it could be that increasing blood levels of Vitamin D could also increase the effects one receives from taking glyconutrients. Or vice-versa. Starting on page 168 of Restructuring I reported that an analysis of people taking glyconutritional plant polysaccharides(GPP) had statistically lower CRP scores than those not taking the GPPs. Although these data are not definitive, the difference could suggest GPPs improve immune health—a finding consistent with our other studies. It would add additional support for the immune supporting potential ofGGPs if blood levels of vitamin D were also found to have a positive relationship with takingGGPs. We are now conducting that study and invite you to be a part of it. If you choose to participate in this study, you may now obtain a measurement of your Vitamin D blood levels for less than half the typical cost--$126 instead of $270 providing you complete an informed consenta self-reported Quality of Life questionnaire, and allow us to use your test data in our longitudinal trials. But even if you don’t participate and are will to pay the full price, I think it would be a good investment in your wellness and immune health to take the test.
Copyright © 2009 by Gilbert R. Kaats, PhD
How much Vitamin D3 Should I Take? The answer depends upon how much D3 you are now taking, how much you are getting from food, how much sunlight you typically get, and how your body metabolizes that D3. However, you should first start with measuring your 25-Hydroxyvitamin D ng/mL blood level to determine your current level:
Severely deficient = 0 to 15 Mildly deficient = 15 to 32 Optimal levels = 32 to 100 Potential toxicity = greater than 100
Other studies suggest that even 250-750 nmol/L would not be toxic. If you don’t get the measurement, virtually no studies suggest taking 2,000 IU a day is toxic, and many suggest that taking up to 10,000 IU of vitamin D3 a day may be safe. It is not unusual to have physicians prescribe 50,000 IU 3 times a week for up to 3 months.
Copyright © 2009 by Gilbert R. Kaats, PhD
Copyright © 2009 by Gilbert R. Kaats, PhD
Informed Consent FormInformed Consent Form
“Another Word From Our Sponsor”Have a Blood Test Panel - for $100 (valued at $436)
Copyright © 2009 by Gilbert R. Kaats, PhD
An American Definition of Exercise
Ex – er - cise. Noun: 1. The art of converting big meals and fattening snacks into back strains and pulled muscles by lifting heavy things that didn’t have to lifted in the first place, or running when no one is chasing you.
Copyright © 2009 by Gilbert R. Kaats, PhD
An Alternative Approach to ExerciseTracks and displays thesteps or step-equivalents
Tracks and displaysthe calories burned
Tracks and displays the miles traveled.
A B C D E F G H
Date Day of Week
# Days
Number of Clicks
Click Equivalents
Total Clicks This Day
Total Clicks This Week
Average Clicks This Week
1-Jan Wed 1 9,254 1,000 10,254 10,254 10,254
2-Jan Thu 2 9,000 - 9,000 19,254 9,627
3-Jan Fri 3 8,000 500 8,500 27,754 9,251
4-Jan Sat 4 9,000 300 9,300 37,054 9,264
5-Jan Sun 5 9,000 9,000 46,054 9,211
6-Jan Mon 6 9,000 450 9,450 55,504 9,251
7-Jan Tue 7 9,000 9,000 64,504 9,215
The Clicker Tracker
0123456789
101112
Week Number
Clic
ks (T
hous
ands
)
1 2 3 4 5 6 7
9 8
1011
12
0
x
x
x
Copyright © 2009 by Gilbert R. Kaats, PhD
The Glycemic Index: Does it Work?
“The findings provide evidence that lowThe findings provide evidence that low--GI diets improve GI diets improve glycemic controlglycemic control……the benefit is clinically significant and the benefit is clinically significant and similar to that offered by newer pharmacological agents.similar to that offered by newer pharmacological agents.””BrandBrand--Miller, Miller, Diabetes CareDiabetes Care, , VolVol 26, 2003.26, 2003.
““In spite of its limitations, the Glycemic Index works.In spite of its limitations, the Glycemic Index works.””An An independent review byindependent review by Sievenpiper & Vuksan,Sievenpiper & Vuksan,
Journal of the American College of NutritionJournal of the American College of Nutrition, , VolVol 23, 2004.23, 2004.
““The Glycemic index information should be incorporated The Glycemic index information should be incorporated into exchanges and teaching materialinto exchanges and teaching material”” and and “…“…diabetic diabetic individuals should be encouraged toindividuals should be encouraged to……include three low include three low GI Foods into their diet daily.GI Foods into their diet daily.””Anderson et. al. Anderson et. al. J the American College of NutritionJ the American College of Nutrition, , VolVol 23, 2004.23, 2004.
Copyright © 2009 by Gilbert R. Kaats, PhD
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Rice chek cereal 1.0 24.7 89 22.0 22.0 Skittles candies 2.3 58.3 70 40.8 17.7Rice Krispies 1.0 24.9 82 20.4 20.4 Smacks, Kellogg's cereal 1.0 25.2 56 14.1 14.1Rice, Basmati white, boiled 7.0 55.9 58 32.4 4.6 Snickers 2.2 37.2 41 15.2 6.9Rice, brown 6.0 131.4 55 72.3 12.0 Soda crackers (saltines) 1.0 20.3 74 15.0 15.0Rice, converted Uncle Ben 6.0 132.7 44 58.4 9.7 Soup, black bean 4.5 10.2 64 6.5 1.5Rice, instant cooked 6.0 136.1 87 118.4 19.7 Soup, green pea 9.0 27.0 66 17.8 2.0Rice, long grained white 6.0 136.0 56 76.2 12.7 Soup, lentil 8.0 25.7 44 11.3 1.4Rice, parboiled 6.0 139.0 48 66.7 11.1 Soup, tomato 9.0 17.4 38 6.6 0.7Rice, vermicelli, cooked 6.0 30.1 58 17.4 2.9 Sourdough bread 1.5 22.1 52 11.5 7.7Rice, white short grained 6.0 48.9 72 35.2 5.9 Soy beans 3.0 8.1 18 1.5 0.5Rice, white, converted, Uncle Ben 6.0 132.7 44 58.4 9.7 Soy milk 8.0 4.3 31 1.3 0.2Roll, Kaiser 2.0 29.9 73 21.8 10.9 Spaghetti, white cooked 6.0 127.3 41 52.2 8.7Rutabaga, peeled, boiled 2.6 6.0 72 4.3 1.7 Sponge cake plain 3.5 57.3 46 26.3 7.5Ryvita tasty dark rye crispbread 0.7 15.6 69 10.7 16.1 Sportsplus 8.0 14.0 74 10.4 1.3Saltine crackers 1.0 20.3 74 15.0 15.0 Star Pastina, cooked 6.0 42.4 43 18.2 3.0Saltines (soda crackers) 1.0 20.3 74 15.0 15.0 Strawberry jam 0.5 8.2 51 4.2 8.4Semolina, cooked 6.0 123.9 55 68.1 11.4 Stuffing or dressing, bread 2.0 12.3 74 9.1 4.6Shortbread cookie 1.0 18.3 64 11.7 11.7 Sweet potato, peeled & boiled 3.0 20.7 54 11.2 3.7
Glycemic Load Index~735 Foods (Alphabetized)
[Chapter 9]
Copyright © 2009 by Gilbert R. Kaats, PhD
Glycemic Load Index~735 Foods (Rank Ordered Lowest to Highest)
[Chapter 9]In
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Lentil soup, canned 8.0 20.7 44 9.1 1.1Soy milk 8.0 4.3 31 1.3 0.2 Sportsplus 8.0 14.0 74 10.4 1.3Yogurt, nonfat, artifical sweetner 8.0 18.2 14 2.6 0.3 Beets, canned 3.0 6.1 64 3.9 1.3Cherries 3.0 4.7 22 1.0 0.3 Peach, fresh 3.0 9.4 42 4.0 1.3Milk, whole 8.0 11.4 27 3.1 0.4 Grapefruit Juice, unsweetened 8.0 22.3 48 10.7 1.3Milk, skim 8.0 11.0 32 3.5 0.4 Life savers candy, 6 peppermint 0.5 1.0 70 0.7 1.4Soy beans 3.0 8.1 18 1.5 0.5 Gatorade 8.0 14.0 78 10.9 1.4Yogurt, -nonfat fruit flavor & sugar 8.0 17.4 33 5.7 0.7 Carrots, peeled and cooked 2.4 6.9 49 3.4 1.4Soup, tomato 9.0 17.4 38 6.6 0.7 Soup, lentil 8.0 25.7 44 11.3 1.4Tomato soup 9.0 17.4 38 6.6 0.7 Potatoes, new canned, drained 5.0 11.7 61 7.1 1.4Grapes, green 3.0 4.9 46 2.2 0.7 Apple juice, unsweetened 8.0 29.0 40 11.6 1.4Peanuts, roasted & salted 2.5 15.2 14 2.1 0.9 Orange, navel 4.0 13.2 44 5.8 1.5Yogurt, nonfat fruit w/sugar 8.0 21.3 33 7.0 0.9 Soup, black bean 4.5 10.2 64 6.5 1.5Peas, dried, boiled 2.0 8.9 22 2.0 1.0 Cantelope, raw 6.5 14.6 65 9.5 1.5Peach, canned, natural juice 4.0 13.1 30 3.9 1.0 Watermelon 5.0 10.2 72 7.3 1.5Apricots, canned 3.0 4.7 64 3.0 1.0 Blackeyed peas, canned 4.0 14.1 42 5.9 1.5Beans, butter boiled 4.0 14.3 31 4.4 1.1 Orange juice 8.0 25.8 46 11.9 1.5Milk, chocolate, 1% 8.0 26.1 34 8.9 1.1 Grapefruit, raw 3.3 7.6 65 4.9 1.5
GLYCEMIC LOAD INDEX - RANK ORDERED FROM LOW TO HIGH
Copyright © 2009 by Gilbert R. Kaats, PhD
Effects of Foods With a High Glycemic-load Index
140
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-60 -30 0 30 60 90 120 150 180 210 240Minutes
INSULIN
GLUCOSE
GLUCAGON
Copyright © 2009 by Gilbert R. Kaats, PhD
Glycemic Load Index--AlphabetizedIn
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Rice chek cereal 1.0 24.7 89 22.0 22.0 Skittles candies 2.3 58.3 70 40.8 17.7Rice Krispies 1.0 24.9 82 20.4 20.4 Smacks, Kellogg's cereal 1.0 25.2 56 14.1 14.1Rice, Basmati white, boiled 7.0 55.9 58 32.4 4.6 Snickers 2.2 37.2 41 15.2 6.9Rice, brown 6.0 131.4 55 72.3 12.0 Soda crackers (saltines) 1.0 20.3 74 15.0 15.0Rice, converted Uncle Ben 6.0 132.7 44 58.4 9.7 Soup, black bean 4.5 10.2 64 6.5 1.5Rice, instant cooked 6.0 136.1 87 118.4 19.7 Soup, green pea 9.0 27.0 66 17.8 2.0Rice, long grained white 6.0 136.0 56 76.2 12.7 Soup, lentil 8.0 25.7 44 11.3 1.4Rice, parboiled 6.0 139.0 48 66.7 11.1 Soup, tomato 9.0 17.4 38 6.6 0.7Rice, vermicelli, cooked 6.0 30.1 58 17.4 2.9 Sourdough bread 1.5 22.1 52 11.5 7.7Rice, white short grained 6.0 48.9 72 35.2 5.9 Soy beans 3.0 8.1 18 1.5 0.5Rice, white, converted, Uncle Ben 6.0 132.7 44 58.4 9.7 Soy milk 8.0 4.3 31 1.3 0.2Roll, Kaiser 2.0 29.9 73 21.8 10.9 Spaghetti, white cooked 6.0 127.3 41 52.2 8.7Rutabaga, peeled, boiled 2.6 6.0 72 4.3 1.7 Sponge cake plain 3.5 57.3 46 26.3 7.5Ryvita tasty dark rye crispbread 0.7 15.6 69 10.7 16.1 Sportsplus 8.0 14.0 74 10.4 1.3Saltine crackers 1.0 20.3 74 15.0 15.0 Star Pastina, cooked 6.0 42.4 43 18.2 3.0Saltines (soda crackers) 1.0 20.3 74 15.0 15.0 Strawberry jam 0.5 8.2 51 4.2 8.4Semolina, cooked 6.0 123.9 55 68.1 11.4 Stuffing or dressing, bread 2.0 12.3 74 9.1 4.6Shortbread cookie 1.0 18.3 64 11.7 11.7 Sweet potato, peeled & boiled 3.0 20.7 54 11.2 3.7
Copyright © 2009 by Gilbert R. Kaats, PhD
Glycemic Load Index(Rank Ordered – Lowest to Highest)
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Lentil soup, canned 8.0 20.7 44 9.1 1.1Soy milk 8.0 4.3 31 1.3 0.2 Sportsplus 8.0 14.0 74 10.4 1.3Yogurt, nonfat, artifical sweetner 8.0 18.2 14 2.6 0.3 Beets, canned 3.0 6.1 64 3.9 1.3Cherries 3.0 4.7 22 1.0 0.3 Peach, fresh 3.0 9.4 42 4.0 1.3Milk, whole 8.0 11.4 27 3.1 0.4 Grapefruit Juice, unsweetened 8.0 22.3 48 10.7 1.3Milk, skim 8.0 11.0 32 3.5 0.4 Life savers candy, 6 peppermint 0.5 1.0 70 0.7 1.4Soy beans 3.0 8.1 18 1.5 0.5 Gatorade 8.0 14.0 78 10.9 1.4Yogurt, -nonfat fruit flavor & sugar 8.0 17.4 33 5.7 0.7 Carrots, peeled and cooked 2.4 6.9 49 3.4 1.4Soup, tomato 9.0 17.4 38 6.6 0.7 Soup, lentil 8.0 25.7 44 11.3 1.4Tomato soup 9.0 17.4 38 6.6 0.7 Potatoes, new canned, drained 5.0 11.7 61 7.1 1.4Grapes, green 3.0 4.9 46 2.2 0.7 Apple juice, unsweetened 8.0 29.0 40 11.6 1.4Peanuts, roasted & salted 2.5 15.2 14 2.1 0.9 Orange, navel 4.0 13.2 44 5.8 1.5Yogurt, nonfat fruit w/sugar 8.0 21.3 33 7.0 0.9 Soup, black bean 4.5 10.2 64 6.5 1.5Peas, dried, boiled 2.0 8.9 22 2.0 1.0 Cantelope, raw 6.5 14.6 65 9.5 1.5Peach, canned, natural juice 4.0 13.1 30 3.9 1.0 Watermelon 5.0 10.2 72 7.3 1.5Apricots, canned 3.0 4.7 64 3.0 1.0 Blackeyed peas, canned 4.0 14.1 42 5.9 1.5Beans, butter boiled 4.0 14.3 31 4.4 1.1 Orange juice 8.0 25.8 46 11.9 1.5Milk, chocolate, 1% 8.0 26.1 34 8.9 1.1 Grapefruit, raw 3.3 7.6 65 4.9 1.5
GLYCEMIC LOAD INDEX - RANK ORDERED FROM LOW TO HIGH
Copyright © 2009 by Gilbert R. Kaats, PhD
Copyright © 2009 by Gilbert R. Kaats, PhD
Percentage of women unable to lift over 10 lbs
45
A Meta Analysis Derived from Source-data*on the Short-term Effects of a Glyconutrient Supplement on Bone Mineral Density©
Reprinted with Permission from The Original Internist, Dec 2008.
by: Gilbert R. Kaats, PhD, FACN, Samuel C. Keith. BBA and Patti L. Keith, BBA Health and Medical Research Center, San Antonio, TX
An additional study enrolled 126 subjects to compare changes in BMD between subjects following the AlgaeCal Bone-health Plan with (n=61)71 and without (n=65) taking glyconutrients supplements. Additionally, all subjects provided self-reported product usage and completed an anonymous reporting their compliance, that allowed for classification of subjects into compliant and non-compliant sub-groups. The results of this study are shown in Figure 3.
*More information on the study can be found on pages [124-125] of the Longitudinal Trials book along with a summary of the research suggesting the possible superiority and benefit of plant-sourced nutrition on pages [121-123].
Glyconutrients Enhance Bone Density When Used with AlgaeCal—A plant-sourcedForm of Calcium Containing Naturally Occurring Bone-Supporting Nutrients*
Copyright © 2009 by Gilbert R. Kaats, PhD
Percentage of women unable to lift over 10 lbs
46
-0.7%
2.2%
3.1%
3.7%
4.4%
-1.0%
0.5%
2.0%
3.5%
5.0%
Ann
ualiz
ed %
BM
D C
hang
esComparison of Annualized Changes in Bone Mineral Density in Different Groups of Highly Compliant Subjects
Following the AlgaeCal Bone-Health Plan With and Without Plant Polysaccharide Glyconutrients (Glycos)
Expected Change
`
Initial AlgaeCal Formula
Final AlgaeCal Formula
Final AlgaeCal Formula
and Glycos
Final AlgaeCal Formula
and Glycos
1
2 3 4 5
1. Expected change in BMD without any intervention for subjects of this age and gender 2. Changes in BMD after taking the initial AlgaeCal formula3. Changes in BMD after taking the final (and current) AlgaeCal formula 4. Changes in BMD after taking the final (and current) AlgaeCal formula with Glyconutrients5. Changes in BMD from "Expected" after taking the final AlgaeCal formula with Glyconutrients
Copyright © 2009 by Gilbert R. Kaats, PhD
Percentage of women unable to lift over 10 lbs
47
In appreciation for their participation in this clinical trial, Mannatech Associates may purchase this supplement at wholesale prices providing they:
1. are a current associate,
2. agree to continue using Mannatech’s glyconutrients,
3. allow us to use any future DEXA or blood chemistry tests as a follow-up to this study.
For information on this product, call HealthTech Products, LLC @ 210.274.6193
Copyright © 2009 by Gilbert R. Kaats, PhD
TABLE OF CONTENTS FOR SLIDESThis power point presentation is copyrighted and cannot be reproduced in any form beyond the initial permission
granted to Building Strength Webinars 9/03/09 attendees
Restructuring Body Composition: How the kind, not amount, of weight lost or gained defines the
pathway to optimal health
To obtaining testing requisitions and participate in on-going clinical trials, contact Integrative Health Technologies, Inc. at
1-210.824.4200
For a copy of the book, pedometer, and wholesale prices for the AlgaeCal Bone Health supplement, contact HealthTech Products, LLC. 210.274.6193
.
To view other resources on this presentation, including DVDs, CDs and
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