Week 11 Isolation of an Active Drug Extraction of ...
Transcript of Week 11 Isolation of an Active Drug Extraction of ...
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Week 11 Isolation of an Active Drug
Extraction of Acetaminophen from a Tylenol Tablet
OH
HN O
Acetaminophen Paracetamol
Pain Killers Active Indredients
Tylenol: Acetaminophen
Excedrin: Acetaminophen + Salicylic Acid +
Caffeine
O N-(4-hydroxyphenyl)acetamide
O OH
N N
O N N
OH Salicylic acid Aspirin
2-Hydroxybenzoic acid
Caffeine 1,3,7-Trimethyl-1H-purine-2,6(3H,7H)-dione
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Tylenol vs
Excedrin
OH
HN
CH3
O
H H
H H
Exchangeable Hs. Broad singlets, hard to see unless sample very dry
solvent
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Experimental Procedure
You are working in pairs!
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Experimental Procedure
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Experimental Procedure
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Experimental Procedure
Simple Distillation + Claisen adapter!
!
Methanol: bp = 65 oC !
Boiling chips important for
smooth boiling (increase surface
area)
!
pear-shaped flask
!