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Outcomes following debridement, antibiotics and implant retention in the management of periprosthetic hip joint infections: a review of cohort studies.
Abstract
Aims
The aims of the study were to review and analyse the reported series of debridement,
antibiotics and implant retention (DAIR) in the management of infected total hip
replacements (THRs) to establish the overall success and the influencing factors.
Patients and methods
Using a standardised and recognised study protocol (“Meta-analysis of observational studies
in epidemiology (MOOSE) guidelines) a comprehensive review and analysis of the literature
was performed. The primary outcome measure of interest was treatment success. The search
strategy and inclusion criteria plus quality assessment yielded 39 articles eligible for analysis,
which included 1296 patients.
Results
The proportion of success from the literature following DAIR in the management of infected
THRs appeared to have improved since 2004 with a pooled mean proportion of success of
72.2%. For all reported series, from 1977 onwards, there was improved success with early
debridement (< seven days) (75.7%) and exchange of modular components (77.5%). There
was a statistically non-significant improvement if debridement was performed within four
weeks of the original surgery (73.0%).
Conclusion
The reported success following DAIR has improved since 2004. The only determinants of
outcome found by this review were the timing of debridement from onset of symptoms and
the exchange of modular components.
Take home message
A DAIR procedure, with exchange of modular components should be considered for acutely
infected THR when presenting within seven days from the onset of symptoms. Future cohorts
should include a core outcome set of relevant data for future meta-analyses.
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Introduction
In the UK over 100,000 primary total hip replacements (THRs) are performed
annually1,2. The numbers, both in the NHS and private health-care sector, have soared over
the last decade. They are expected to continue rising over the next 25 years. While all
complications are undesirable, the most feared complication of THR is infection, due to its
resistance to conservative treatment with standard antibiotic therapy3. The choice of treatment
for periprosthetic joint infections (PJIs) generally depends on a number of factors, including
local factors referring to the bone and tissue condition, fixation and stability of the prosthesis,
the chronicity of infection, the type of organism, and the host’s condition3–5. In the case of
early infection, within four 4-twelve 3 weeks of the original surgery, onset debridement,
antibiotics and implant retention (DAIR) can be a first-line option 3,4. However there is a very
wide range of reported proportions of success for DAIR in the management periprosthetic hip
infections ranging from 14%6-100%7–9. Treatment of acute THR infections with debridement
and implant retention was first reported in the 1974 by Müller 10 and then Coventry 11 in 1975
with an 80% and 20% success, respectively. Burton and Schurman 12 reported their experience
with the technique in 1977 with 75% remaining infection. The approach by Burton and
Schurman was “radical debridement of all necrotic debris and removal of the prosthesis,
where the prosthetic components were loose or bone involvement was present. The patients
were treated with wound irrigation with an appropriate antibiotic and were maintained on
high doses of parenteral antibiotics for as long as possible 12 .” Muller and Coventry described
similar techniques with Coventry advocating “closure over tubes” to encourage drainage of
purulent material 11 . With further reports of experience with the technique factors thought to
improve treatment success included onset of PJI within the first four weeks following
implantation 13 ; debridement initiated early after the onset of symptoms of infection 14 ; the
absence of a sinus tract or radiographic signs implant loosening at the time of debridement 15 ;
and the type, duration, and route of antimicrobial therapy 16–19 .
Aims
The aims of the study were to analyse and summarise the reported series to establish
the overall proportions of success following DAIR in the management of periprosthetic hip
infections and secondarily to identify risk factors for failure.
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Methodology
Search strategy.
A computerized literature search was conducted in the MEDLINE, and Science
Citation Index Expanded (ISI Web of Science) databases for relevant reports from their
inception to May 2016. The following algorithm was applied to both the Medical Subject
Heading (MeSH) and the full text: (1) “total hip replacement” OR “total hip arthroplasty” OR
“arthroplasty” OR “hip joint” OR “joint prosthesis” OR “hip prosthesis” AND “infection” (2)
“debridement” OR “implant retention” or “treatment outcome” (MeSH terms). The
bibliographies of the retrieved studies and other relevant publications, including reviews and
meta-analyses, were examined for additional articles. No language restrictions were imposed.
Study selection criteria.
Articles were included if 1) they contained raw outcome data from a group
undergoing DAIR for the management of infected THRs; 2) infection was defined as per
established criteria4,14,20; 3) reported the primary outcome of interest; and 4) were
observational studies (either prospective or retrospective in design). No distinction was made
of type or size of implant used or whether the prosthesis was cemented or uncemented.
The primary outcome measure of interest was treatment success. Successful treatment
was defined as per international multidisciplinary consensus 21 1) absence of
recurrent/persistent periprosthetic infection; 2) no requirement for long-term antibiotic
suppression; 3) no requirement for revision surgery; 4) no excision of prosthesis, and 5) no
mortality due to periprosthetic infection-related sepsis.
Data collection
Data was extracted by a single reviewer (S-TJT) and checked by the project
supervisors (PG and AHRW). Any discrepancies were discussed, if a consensus was not
reached, the study was excluded. Data was extracted for: first author’s last name; study
design; study characteristics (including year and country of study); sample size; proportion
completing follow-up; duration of follow-up; subject characteristics (sex distribution and
mean age at time of surgery); timing of debridement surgery (median duration from primary
surgery and from symptom onset); number of DAIR procedures performed; modular
component exchange at time of debridement; and proportion of success. Study quality was
assessed independently and scored by a single reviewer using the Newcastle–Ottawa Scale22
(NOS). The NOS is a validated tool for assessing the quality of non-randomized studies,
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including cohort and case–control studies. The maximum score a study can achieve is nine 22.
Only those considered of adequate quality (≥7) were included in the analyses. The
Newcastle-Ottawa scores for each included study are presented in Table 1. The mean score
was 7.90 (±0.55).
Meta-analysis
Meta-analysis of observational studies carries many inherent potential challenges
related to biases and diversity in the original studies, performing such analyses is an accepted
technique provided it is conducted according to well established guidelines. This review of
observational studies was conducted in accordance to the meta-analysis of observational
studies in epidemiology (MOOSE) guidelines 34 . Data were analysed using SPSS statistical
software version 21.0 (SPSS Inc., Chicago, Illinois) and Microsoft Excel 2016 (Microsoft,
Redmond, Washington, USA). For continuous outcomes the weighted mean difference was
calculated along with the 95% confidence intervals (CI). Subsequent comparisons were
performed using Student’s T-test and univariate analysis of variance (ANOVA) for
parametric data and Mann-Whitney U test for non-parametric data.
Results
The search strategy revealed 1370 clinical trials. Thirty-nine case-control and cohort
trials, reporting on the outcome of 1296 patients, were suitable for inclusion. Table 1 . details
the study characteristics for each included trial. Review and observational studies were
excluded due to ‘no raw data reported’ (n=9) and ‘mixed cohort (prosthesis or treatment)’
(n=33) (Fig.1).
Overall proportion of success following DAIR
The overall proportion of success following DAIR in the management of infected
THRs was 64.7% (836/1296 patients) (Table. 1).
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Author Year Country Study period (start)
Study period (end)
Average time from primary
surgery to debridement
Average time from onset of symptoms to debridement
Infection criteria
Sample size (n)
Mean age
(years)
Average follow-up (months)
Success (n)
Success (%)
Culture results
Total duration of antibi-otic ther-
apy (weeks)
Removable components exchanged at debridement
More than 75% had >1 debridement
NOS* Selection
score
NOS* Com-parability
score
NOS* Ex-posure score
NOS (total)
Burton et al12 1977 US 1971 1975 >4weeks >7days Positive culture specimens
4 35 14 2 50 Mixed Not re-ported
No No 3 2 2 7
Morscher et al23 1990 Switzerland 1980 1986 Not reported Not reported Positive culture specimens
6 72 37 4 67 Mixed Not re-ported
No No 3 2 3 8
Collins et al24 1991 US 1972 1987 Not reported Not reported Positive culture specimens
34 59 48 15 44 Mixed Not re-ported
No Yes 2 2 2 6
Tsukayama et al13 1996 US 1980 1991 <4weeks >7days Tsukayama criteria
41 63 46 28 68 Mixed 6 Yes No 3 2 3 8
Crockarell et al25 1998 US 1975 1991 Not reported >7days Tsukayama criteria
42 58 72 9 21 Not re-ported
Not re-ported
No Not reported 3 2 3 8
Krasin et al26 2001 Israel 1995 1997 >4weeks >7days Positive culture specimens
7 68 30 2 29 Gram +ve
6 No No 3 2 3 8
Kilgus et al6 2002 US 1997 2001 Not reported Not reported Tsukayama criteria
35 65 27 5 14 Mixed Not re-ported
Yes Yes 2 2 3 7
Meehan et al27 2003 US 1969 1998 >4weeks <7days Mayo cri-teria
6 67 60 4 67 Gram +ve
Not re-ported
Yes Yes 3 2 3 8
Soriano et al28 2003 Spain 1997 2000 >4weeks Not reported Positive culture specimens
10 69 22 9 90 Mixed 6 No No 3 2 3 8
Giulieri et al29 2004 Switzerland 1984 2001 >4weeks Not reported Positive culture specimens
11 72 28 7 64 Mixed 100 No Not reported 3 3 3 9
Theis et al30 2007 NZ 1990 2000 >4weeks <7days Tsukayama criteria
36 74 56 19 53 Gram +ve
Not re-ported
No No 3 2 3 8
Aboltins et al31 2007 Australia 1998 2003 >4weeks >7days US CDC criteria
13 70 44 12 92 Gram +ve
72 Yes Not reported 3 2 3 8
Parvizi et al32 2009 USA 1999 2006 Not reported >7days Parvizi cri-teria
24 65 Minimum 24 months
8 33 Gram +ve
Not re-ported
No Not reported 4 2 3 9
Byren et al33 2009 UK 1998 2003 >4weeks <7days Positive culture specimens
52 70 28 45 87 Mixed 52 Yes No 3 2 3 8
Tintle et al8 2009 USA 2002 2004 <4weeks <7days US CDC criteria
3 56 39 3 100 Mixed 6 Yes Yes 3 2 3 8
Azzam et al34 2010 USA 1997 2005 >4weeks >7days Parvizi cri-teria
53 65 68 24 45 Mixed Not re-ported
Yes Not reported 3 2 3 8
Estes et al7 2010 USA 2002 2009 >4weeks <7days Parvizi cri-teria
4 65 58 4 0 Mixed Not re-ported
Yes Yes 3 2 3 8
Aboltins et al35 2011 Australia 1998 2007 <4weeks <7days Mayo cri-teria
15 75 28 13 87 Gram -ve
75 Yes Yes 3 2 3 8
Koyonos et al36 2011 USA 1996 2007 Not reported Not reported Parvizi cri-teria
60 64 54 18 30 Mixed Not re-ported
Not reported Not reported 3 2 3 8
Vilchez et al37 2011 Spain 2000 2007 <4weeks <7days Positive culture specimens
18 70 25 16 89 Gram +ve
14 Yes No 3 2 3 8
Engesæter et al38 2011 Norway 1987 2009 >4weeks Not reported Registry coding
180 72 Not repor-ted (Re-
gistry data)
146 81 Not re-ported
Not re-ported
Yes No 3 2 3 8
Cobo et al39 2011 Spain 2004 2006 <4weeks >7days Tsukayama criteria
57 77 26 30 53 Mixed 12 Yes No 2 2 3 7
Klouche et al40 2011 France 2002 2008 Not reported <7days Tsukayama criteria
12 69 30 3 25 Mixed 12 Yes No 3 2 3 8
Buller et al41 2012 USA 1996 2010 >4weeks >7days Mayo cri-teria
62 65 34 35 56 Mixed 6 Yes Not reported 3 2 3 8
Sukeik et al42 2012 United King-dom
1999 2006 <4weeks >7days Sukeik cri-teria
26 70 79 20 77 Gram +ve
6 Yes No 3 2 3 8
Choi et al43 2012 USA/Switzerland
1999 2007 <4weeks Not reported Tsukayama criteria
28 65 Not repor-ted
19 68 Gram +ve
6 Yes No 3 2 2 7
Perez-Cardona et al9
2012 Spain 2008 2010 <4weeks Not reported Tsukayama criteria
5 84 14.6 5 100 Not re-ported
11 No No 3 2 3 8
Westberg et al44 2012 Sweden 1998 2005 <4weeks Not reported Tsukayama criteria
38 75 48 27 71 Mixed 7 Yes No 3 2 3 8
Kuiper et al45 2013 Netherlands 2004 2009 >4weeks Not reported Crockarell criteria
34 73 35 25 74 Mixed 18 No Yes 3 2 3 8
Kuiper et al46 2013 Netherlands 2004 2009 <4weeks <7days Crockarell criteria
62 70 35 38 71 Mixed Not re-ported
Yes Not reported 3 2 2 7
Geurts et al47 2013 Netherlands 1982 2010 <4weeks Not reported Mayo cri-teria
69 69 27 57 83 Gram +ve
13 No Yes 3 2 3 8
Peel et al48 2013 Australia 2000 2010 <4weeks <7days Mayo cri-teria
28 73 34 20 71 Gram +ve
Not re-ported
Yes Yes 3 2 3 8
Merollini et al49 2013 Australia 2006 2009 >4weeks Not reported US CDC criteria
68 72 Not repor-ted
41 60 Not re-ported
Not re-ported
No Not reported 4 2 3 9
Aboltins et al50 2013 Australia 2006 2009 <4weeks <7days US CDC criteria
19 69 24 17 89 Mixed 52 No Yes 3 2 3 8
Konigsberg et al51 2014 USA 1995 2006 Not reported <7days Mayo cri-teria
20 60 56 16 80 Mixed 42 Yes No 3 2 3 8
Betz et al52 2014 Switzerland 1996 2012 Not reported Not reported Positive culture specimens
38 78 42 31 82 Gram +ve
12 Yes Yes 2 2 3 7
Moojen et al53 2014 Netherlands 2001 2008 <4weeks Not reported Positive culture specimens
33 74 48 29 88 Gram +ve
12 Yes No 3 2 3 8
Moojen et al54 2015 Netherlands 2001 2008 <4weeks Not reported Positive culture specimens
35 67 Not repor-ted
25 71 Mixed 12 No Yes 3 2 3 8
Veltman et al55 2015 Netherlands 2008 2013 <4weeks Not reported Positive culture specimens
8 80 36 7 88 Gram -ve
12 Yes Yes 3 2 3 8
*Newcastle-Ottawa score22
Table 1. Comparison of studies evaluating the outcomes following debridement, antibiotics, and implant retention (DAIR) in the management of peripros-thetic hip joint infections
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Statistical analysis of influencing factors following DAIR
Studies published before 2004 6,12,13,23–29 were found to have a lower proportion of
success with a mean success of 43.3% (85/196 patients) (95% CI 36.3-50.6). Studies
published after 2004 7,9,30,32,34–55 had a mean proportion of success of 67.2% (693/1032 patients)
(95% CI 64.2-70.0). This difference was found to reach statistical significance (p<0.0001).
Studies published after 2004 but had treatment periods that ended prior to and including 2004
were excluded 8,31,33 from this analysis. A similar pattern was seen if studies were grouped by
treatment period. For studies where all patients were treated prior to 2004 6,12,13,23–31,33 the mean
proportion of success was 54.2% (161/297) (95% CI 48.3-60.0) compared with 67.7%
(674/996 patients) (95% CI 64.7-70.6) in studies which included patients treated after
2004 7,9,32,34–55. Again this difference was found to be statistically significant (p<0.0001). One
study 8 which had a treatment period from 2002-2004 was excluded from this analysis.
Overall there was a non-statistically significant trend of increasing proportions of success in
last fifteen years ( Fig. 2 ).
The time from onset of symptoms to surgical debridement was also found to be
associated with a difference in the proportion of success. A bubble plot demonstrated a non-
linear relationship between time from onset of symptoms to surgical debridement and
treatment success. A decline in treatment success was noted in studies that had a median time
from symptom onset to surgical debridement of greater than seven days (Fig.3). In the
studies where the median time from onset of symptoms to surgical debridement was more
than seven days 12,25,26,32,34,39,41,42 the pooled proportion of success was 51.8% (170/329 patients)
(95% CI 46.1-57.2). In studies where the median time from onset of symptoms to surgical
debridement was less than seven days 7,8,27,30,33,35,40,46,48,50,51,56 the pooled proportion of success
was 72.0% (198/275 patients) (95% CI 66.3-77.2), which was found to be significantly
different (p<0.0001).
Alternatively, in studies where the median time from primary surgery to surgical
debridement was less than four weeks 8,9,13,35,37,39,42–44,46–48,50,53–55 the mean proportion of success
was 73.0% (354/485 patients) (95% CI 68.8-76.9). The pooled proportion of success where
the median time from primary surgery to surgical debridement was more than four
weeks 7,12,26–31,33,34,38,41,45,49 was 69.4% (375/540 patients) (95% CI 65.4-73.3), this difference
was not found to be statistically significant (p=0.215).
In the studies where <25% of patients had multiple debridements 9,12,13,23,26,28,30,33,37–40,42–
44,51,53 the proportion of success was 73.3% (420/573 patients) (95% CI 69.5-76.9). This was a
higher proportion of success than the studies where the majority of patients (>75%) had
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multiple debridements 6–8,24,27,35,45,47,48,50,52,54,55 (68.9% (226/328 patients), 95% CI 63.6-73.9).
However this difference was not found to reach statistical significance (p=0.167).
In studies where all patients underwent exchange of modular components (e.g.
femoral head or acetabular liner) at the time of surgical debridement 6–8,13,31,33,35,37–40,42–
44,48,51,52,54,55 the mean proportion of success was 74.0.7% (471/637) (95% CI 70.3-77.3). This
was higher than in those studies where no component exchange took place 9,12,23–26,28–
30,32,36,45,47,49,50,54 (60.7% (245/404), 95% CI 55.7-65.4), which was found to be statistically
significant (p<0.0001).
Discussion
This review found an overall proportion of success 64.7% associated with DAIR
treatment of infected THRs. An earlier and smaller meta-analysis by Romano et al (2012)
reported a lower proportion of success with DAIR, a pooled average success of 55.9% and
52.0% after a single or multiple debridement and irrigation procedures, respectively57.
However the meta-analysis conducted by Romano et al58 included mixed cohorts of infected
total hip and knee replacements treated with DAIR between 1970 and 2011. Only one study
was included that reported the outcome of infected THRs undergoing DAIR, Klouche et al40,
in which 75% of DAIR were successful. A recent case-control study from Oxford reported a
68% success following initial DAIR 58 with a similar complication rate and ability to eradicate
infection as two-stage revision. Overall there is a wide range, 14%6-100%7–9, of reported
success following DAIR in the management of infected THR. The proportion of success
appeared to improve with time ( p<0.0001 ) . In 2004 Zimmerli et al 3 and Darouiche 59
published two highly influential reviews in the New England Journal of Medicine
summarising the management of periprosthetic joint infections. These two papers are the two
most cited articles on the management of PJI. This was found using the following topic
search terms; “Prosthetic joint infection,” “Periprosthetic joint infection,” “Infection” (with
refinement using subject field “Orthopedics”), and “Prosthetic infection” in the Science
Citation Index Expanded database on the Web of knowledge website. The results were
further cross checked using Google Scholar and a cited reference search of Institute for
Scientific Information (ISI) listed Orthopaedic journals (n=79) as per the methodology
described by Lefaivre et al 60. Within the Zimmerli et al review a treatment algorithm was
proposed. We hypothesise that there may have been a learning effect amongst surgeons after
2004 as the indications for DAIR and the risk factors associated with its failure become better
defined. Equally this trend could be a result of publication bias as only studies reporting
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improved success proportions following DAIR were being submitted to and accepted by
journals.
Factors which have been postulated to influence the outcome of DAIR in the
management of infected joint replacement include the timing of debridement14,27,61, number of
debridements53,54, exchange of removal components4,62, responsible micro-organism33,35,48,63–67,
and duration of antibiotic therapy9,39,40,44,52–55.
In this review, the timing of debridement was found to have an influence on the
proportion of success following DAIR. There was a statistically significantly greater success
when debridement took place at a median time of less than seven days from the onset of
infective symptoms (72.0% vs 51.8%, p<0.0001) compared with debridement being
performed at a median time after one week. This relationship was also demonstrated in
Figure. 4. There was a notable outlier with a treatment success of 77% despite the median
time to surgical debridement being 15 days42. In this series 16/26 infections were caused by
low virulence organisms such as Coagulase-negative Staphylococcus, Acinetobacter,
Propionibacterium spp, and Corynebacterium spp which have been found to be more
common in seronegative infections68. This study is of particular interest as, the high
proportion of low virulence infections may have been a factor in the relatively high treatment
success despite the increased time to surgical debridement, suggesting that late DAIR
procedures may still have a high chance of success in patients infected with these organisms.
However, further data is needed to confirm this. One study was excluded from the analysis as
patients were treated with median time of twelve months of post-debridement antibiotic
therapy31 which differed vastly from the included studies in this analysis. Studies from the
Mayo clinic 14,27 found that duration of symptoms and time from implantation influenced
proportions of success following DAIR. Brandt et al 14 reported that if debridement took place
more than two days after the onset of symptoms there was a four-fold increase in treatment
failure. Other centres have reported similar findings, Tattevin et al 69 reported a 100%
proportion of success when debridement was performed within five days of symptom onset.
A recent case-control study conducted by Grammatopoulos et al also reported an improved
ten-year THR survival (87% vs 65%) with DAIR performed less than one week between
symptoms and onset of surgery 58. The importance of the timing of debridement is thought to
be related to the “race to the surface,” as described by Gristina and Costerton70, and
subsequent maturation of the biofilm. Complete maturation of the biofilm is thought to occur
within two to four days of bacterial attachment71,72. It is thought that once maturation has
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taken place irrigation is largely ineffective with re-establishment of the biofilm on the
retained prosthesis within 24 hours73.
A similar relationship has previously been reported regarding the timing of
debridement from initial implantation. Hartman et al61 found that that proportions of success
following DAIR in the management of infected total knee replacements were statistically
higher if debridement occurred within four weeks of implantation (63.6% vs 27.3%). A cut-
off at four weeks has been incorporated into established treatment protocols4. In this meta-
analysis there was a higher proportion of success when the mean time from primary surgery
to surgical debridement in total hip replacements was less than four weeks (73.0% vs 69.4%)
compared to those when debridement was performed after four weeks. However this
difference was not statistically significant (p=0.215). Fehring et al also found that
debridement within 30 days of implantation was not associated with improved proportion of
success (54% vs 24%, p=0.075)73.
Previously there has been debate as to whether single surgical debridement was
sufficient or whether multiple repeat procedures were necessary for optimal treatment.
Moojen et al reported a retrospective comparative study between two different treatment
protocols. Patients in the first protocol received a single surgical debridement and only
additional surgery if infectious symptoms persisted. Patients adhering to the second protocol
always received multiple surgical debridements. There was no statistical difference in
successful outcomes between the two groups (88% vs 71%, p=0.09)53. In this meta-analysis a
similar result was found when comparing studies where >75% patients had multiple
debridements with those where <25% had multiple debridements (68.9% vs 73.3%, p=0.167).
This may be a reflection that those in studies undergoing multiple debridements were
associated with more virulent organisms or had poor host responses rather than the futility of
multiple debridements.
Exchange of modular components at the time of debridement is recommended in the
most commonly used guidelines and treatment algorithms62,74. In this review we found a
statistical effect on outcome following DAIR with exchange of modular components (60.7%
vs 74.0%, p<0.0001). A similar effect was found in a recent case-control study with exchange
of modular components at debridement associated with a 90% ten year THR survival58.
This study was conducted in accordance with established epidemiological meta-
analyses guidelines (MOOSE)75.All included studies have been shown objectively to be of
sufficient quality through the NOS criteria22. The study was limited by the quality and
quantity of the available data. The heterogeneity of research methodologies, surgical
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techniques and treatment protocols, expertise of the treatment centres, patient populations,
and reported outcomes along with the long study period of the cohorts could produce
confounding factors. These confounding factors would need to be taken into account when
interpreting the results of this review. In the analysis of influencing factors summary data of
study outcomes rather than individual outcomes has been used, as in many studies data at an
individual level was not available. The findings produced may not necessarily hold if the
same analysis was performed using individual patient outcomes for each influencing factor.
There is a need for the global use of harmonised observational research methodologies, such
as The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)
statement: guidelines for reporting observational studies 76 . Another would be the creation of
“core outcome sets 77–79 ” for this particular area of orthopaedic research (Table 2). These have
been established in other medical specialties such as rheumatology80 in an attempt to
standardise research and ease interpretation of the literature. Finally further research into this
area of PJI management using more robust research methodologies and clinically relevant
outcomes, such as a randomised control trial and patient reported-outcome scores
respectively, are also recommended.
Table 2. Suggested core outcome set in the reporting of DAIR procedures.
Host Primary surgery
Surgery Microbiology
Antibiotic therapy
Outcome
Age Prosthesis-type (Cemented vs uncemented vs hybrid)
Time from onset of symptoms to initial debridement
Organism Duration Follow-up duration
Host status (Local and systemic factors. Adpoted from Cierny and DiPasquale81)
Time from primary surgery to initial debridement
Antimicrobial sensitivity
Delivery (local and/or systemic)
Criteria for success1. Absence of
recurrent/persistent periprosthetic infection;
2. No requirement for long-term antibiotic suppression;
3. No requirement for revision surgery;
4. No excision of prosthesis,
5. No mortality due to periprosthetic infection-related sepsis
Surgical approach
Exchange of modular components
Patient-reported outcome scores
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In conclusion, the reported outcomes following DAIR appear to be improving with
time as indications are refined and risk factors identified. The most influential determinants
of outcome are timing of debridement from onset of symptoms and exchange of modular
components at the time of initial debridement, and to a lesser extent the time from the
original primary surgery. Surgeons should consider a DAIR procedure with exchange of
modular components for acutely infected THR when presenting within seven days from the
onset of symptoms.
Word count including bibliography: 5254 (excluding bibliography 2900)
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