— PREP 2020 Preliminary Scientific Program —Submit Poster Abstracts – coming soon

(program as of 5-12-2020)

PREP 2020 ChairGiorgio Carta, University of Virginia

Organizing Committee

Lois Ann Beaver, LAB EnterprisesGiorgio Carta, University of Virginia (Chair)

Olivier Dapremont, AMPAC Fine ChemicalsChen Wang, AbbVie

Scientific Advisory Committee

Dorota Antos, Rzeszow Univ. of Tech., PolandSteven Cramer, Rensselaer Polytechnic InstituteAttila Felinger, University of Pecs, HungaryRanga Godavarti, PfizerKent Goklen, GlaxoSmithKlineAlois Jungbauer, BOKU, Vienna, AustriaAbraham Lenhoff, University of DelawareMassimo Morbidelli, Politecnico di Milano, Italy

Igor Quinones-Garcia, Mersana TherapeuticsDavid Robbins, AstraZenecaDavid Roush, Merck & Co., Inc. Melody Schmidt, GenentechAndreas Seidel-Morgenstern, Max-Planck Institute, Magdeburg, GermanyOwen Thomas, University of Birmingham, UKShuichi Yamamoto, Yamaguchi University, Japan

Industrial Advisory Committee

Geoffrey Cox, Chromatography ConsultantFred Ghanem, Purolite Life SciencesPeter Hagwall, GE Healthcare Life SciencesJin Seok Hur, NovasepMarc Jacob, PhenomenexKosuke Kabe, DAISO Fine Chem USA, Inc.

Jiali Liao, Bio-Rad LaboratoriesCecilia Mazza, NouryonKathleen Mihlbachler, YMC Process TechnologiesLaszlo Frici Nemeth, ConsultantErnie Sobkow, Consultant

Poster Session ChairTBA

Symposium / Exhibit ManagerMs. Janet Cunningham, Barr Enterprises

Phone 301-668-6001janet@barrconferences.com

LinkedIn.com/in/BarrEnterprisesPREPsymposium.org

PREP 2020 Workshop and Tutorial Training ProgramThe Training Workshop program provides advanced coverage of various aspects of preparative and process chromatography. Dynamic presentations covering both fundamentals and practical aspects are presented by leading academic and industrial scientists and cover both fundamentals and real-world applications. Morning Tutorials that address quality by design and the emerging applications of 3D printing in separation science and technology. The presentations will provide the knowledge you need to implement preparative and process chromatography to solve today's separation problems as well as to understand tomorrow's technology. Workshops and Tutorials are open to conference and non-conference participants. See details and pricing posted online under "Workshops & Tutorial" and under “Registration” at PREPsymposium.org. Must pre-register to attend.

Sunday, May 31 Workshops (See registration form for cost) Instructors

9:00 AM - 1:00 PMMaryland Suite “COLUMBIA”2nd floor

Fundamentals of Preparative Chromatography for Biomolecules by Batch and Continuous Processes Focus on biomolecule chromatography, stationary phases, binding capacity and selectivity, mass transfer, modeling, design for capture and resolution, multicolumn and continuous chromatography processes.

Giorgio Carta, University of Virginia Alois Jungbauer, BOKU, ViennaMassimo Morbidelli, Politecnico di Milano

2:00 PM - 6:00 PMMaryland Suite “COLUMBIA”2nd floor

Fundamentals of Preparative Chromatography for Purification of Small and Intermediate Size APIs by Batch Chromatography, SMB, and SFCFocus on small molecules, APIs, peptides, oligonucleotides, chiral molecules, HPLC, column packing, gradient elution, overloaded chromatography, SFC, SMB, examples and industrial applications.

Olivier Dapremont, AMPAC Fine Chemicals Geoffrey Cox, Chromatography Consultant

Tuesday, June 2 Tutorial(See registration form for cost) Instructor

7:00 AM - 8:25 AM Maryland Suite “COLUMBIA”2nd floor

Practical Concepts on Process Characterization and Validation of Biopharmaceuticals based on QbD PrinciplesFocus on Quality by Design, quality risk management, overall process control strategy, process characterization, application examples.

Gisela Ferreira, AstraZeneca

Wednesday, June 3 Tutorial(See registration form for cost) Instructor

7:00 AM - 8:25 AM Maryland Suite “COLUMBIA”2nd floor

3D Printing in Separation ScienceFocus on how 3D printing is impacting the separation sciences in general, and chromatography in particular.

Simone Dimartino, University of Edinburgh

Workshop 1: Sunday, May 31, at 9:00 AM - 1:00 PMFundamentals of Preparative Chromatography for

Biomolecules by Batch and Continuous ChromatographyWorkshop registration is in addition to the symposium registration fee;

open to conference and non-conference participants.Location: Maryland Suite “COLUMBIA”, 2nd floor

Must pre-register/pay to attend at PREPsymposium.org

Focus:  Biomolecule chromatography, stationary phases, binding capacity and selectivity, mass transfer, modeling, design for capture and resolution, multicolumn and continuous chromatography processes.

 This workshop will focus on the theory and practice of biomolecule chromatography. Since mass transfer and the structure of the stationary phase influence deeply chromatographic performance, the main emphasis is on describing adsorption/desorption kinetics in single and multicomponent systems and determining the relationship between stationary phase properties and process performance. The latest advances in stationary phase developments will be reviewed along with methods for their experimental characterization. Design and optimization strategies for capture and resolution applications will be discussed including multicolumn and continuous bio-chromatography processes.  

 Topics:  Adsorption equilibrium and transport in single and multicomponent systems; Stationary phases for small and large biomolecules; Design and optimization of batch processes for capture and high-resolution steps; Multicolumn and continuous bio-chromatography processes; Process validation.

 Lecturers:

 Giorgio Carta received his Ph.D. in Chemical Engineering from the University of Delaware in 1984. Since then he has been a professor in the Department of Chemical Engineering at the University of Virginia, where his research focuses on transport phenomena and bioseparations. He regularly organizes professional courses on various aspects of bioseparations, including a course on protein chromatography development and scale-up together with Alois Jungbauer.  

 Alois Jungbauer is the head of protein technology and downstream processing at the Department of Biotechnology of the University of Natural Resources and Applied Life Sciences in Vienna (Austria). For more than 20 years, Professor Jungbauer has worked in biochemical engineering, with a focus on bioseparation, where he has published widely and holds 15 patents. For over 10 years, he has organized a biennial professional course in protein chromatography focused on mass transfer, dispersion, and scale-up.

 Massimo Morbidelli received his Laurea in Chemical Engineering at the Politecnico di Milano in 1977, and his Ph.D. in Chemical Engineering at the University of Notre Dame in 1986. After appointments as professor at the University of Cagliari (Italy) and at the Politecnico di Milano, from 1997 to 2019 he was Professor of Chemical Reaction Engineering at the Institute for Chemical and Bioengineering at ETH Zurich (Switzerland) and is currently Professor in the Department of Chemistry, Materials, and Chemical Engineering at Politecnico di Milano, Italy. His research interests are in polymer reactions and reaction-separation processes based on continuous chromatography and in biomolecule purification with specific focus on therapeutic proteins and monoclonal antibodies. He is co-author of more than 500 papers, 11 international patents and 4 books. He serves as an associate editor of Industrial & Engineering Chemistry Research, and is a member of the scientific board of several international journals. He is the recipient of the 2005 R.H. Wilhelm Award in Chemical Reaction Engineering of the American Institute of Chemical Engineers, of the 2017 AIChE Award for Excellence in Process Development Research, of the 2018 ACS Award in Separations Science & Technology, and of the 2019 ICB Award in Integrated and Continuous Biomanufacturing. 

 

Workshop 2: Sunday, May 31, at 2:00 - 6:00 PMFundamentals of Preparative Chromatography for Purification of Small and Intermediate Size APIs by

Batch Chromatography, SMB, and SFCWorkshop registration is in addition to the symposium registration fee;

open to conference and non-conference participants.Location: Maryland Suite “COLUMBIA”, 2nd floor

Must pre-register/pay to attend at PREPsymposium.org 

Focus:  Small molecules, APIs, peptides, oligonucleotides, chiral molecules, HPLC, column packing, gradient elution, overloaded chromatography, SFC, SMB, examples and industrial applications.

 This workshop will focus on development of methods for the preparative purification of small molecules for the pharmaceutical industry. After an introduction of the theory, optimization and practice of prep HPLC, SMB and SFC for small molecule separations, the instructors will present practical approaches to the development of preparative separation through a series of examples. The attendees will learn valuable information and techniques to apply in the laboratory and at manufacturing scale to increase throughput and performance.

 Topics:  Prep HPLC batch - Theory, optimization and practice; SMB - Principle and technology; SMB - Examples and applications; SFC - Theory, equipment and examples.

 Lecturers:

 Olivier Dapremont received his Ph.D. in Chemical Engineering and Applied Chemistry from University of Paris on the development of continuous chromatography for the pharmaceutical industry.  He has worked on the development of SMB technology since 1992. He is currently Executive Director of Process Technologies at AMPAC Fine Chemicals where his role encompasses the development of SMB separations using multiple SMB units ranging from 4.6 mm to 1 m in diameter as well as developing continuous processes for the manufacturing of APIs.  He is coauthor of several publications and patents related to the use of SMB applications for the purification of small molecules. 

Geoffrey Cox received his Ph.D. in Organic Chemistry from the University of Sheffield, England. Since then his career has been centered around chromatography, starting with preparative gas chromatography through introduction of HPLC to the premier Government analytical laboratory in the UK, development of bonded stationary phases and moving to preparative and industrial scale chromatography first with Du Pont and then in the mid-1980s as Director R&D with Prochrom. In 1997 he moved to Chiral Technologies, first in Europe before relocating to the USA as VP Technology, working in chiral separations. In March 2011 he started the US subsidiary of PIC Solution, the French SFC manufacturer, in order to expand the company’s business into North America. Since 2019 he serves as a chromatography consultant. He is author and coauthor of several publications and patents related to the use of chromatography for the purification of small molecules using multiple techniques. 

 

Tutorial: Tuesday, June 2, at 7:00 - 8:25 AMPractical Concepts on Process Characterization and Validation of

Biopharmaceuticals based on QbD PrinciplesTutorial registration is in addition to the symposium registration fee;

open to conference and non-conference participants.Location: Maryland Suite “COLUMBIA”, 2nd floor

Must pre-register/pay to attend at PREPsymposium.org

Focus: This workshop will focus on Quality by Design, quality risk management, overall process control strategy, process characterization, and application examples.

Topics:  This interactive tutorial introduces principles of Quality by Design including preparation of risk assessments, design of experiments for process characterization, statistical strategies for data analysis and validation of biopharmaceutical processes. Topics: Quality by Design, quality risk management, process characterization strategies, overall process control strategy, application examples and relevant regulatory documentation.

Lecturer:

Gisela Ferreira received her Ph.D. in Chemical Engineering from the University of Maryland Baltimore County in 2001 and is currently an Associate Director in the Purification Process Sciences at AstraZeneca. Dr. Ferreira has broad biotechnology experience and expertise in areas including process development for large-scale cGMP manufacture of biologics, recombinant biopharmaceutical purification (early and late stage development), Quality by Design concepts, scale-up, technology transfer, CMC project management, virus clearance studies, and activities related with preparation/interactions/response to documents in regulatory interactions.

Tutorial: Wednesday, June 3, at 7:00 - 8:25 AM3D Printing in Separation Science

Tutorial registration is in addition to the symposium registration fee; open to conference and non-conference participants.

Location: Maryland Suite “COLUMBIA”, 2nd floorMust pre-register/pay to attend at PREPsymposium.org

Focus:   This tutorial offers an overview of how 3D printing is impacting the separation sciences in general, and chromatography in particular. 3D printing can seamlessly create bespoke models with complex shapes, using a range of materials, and with resolution that can reach the submicron-scale. This capability opens a new way to fabricate stationary phases, column housings, filtration elements, extraction units and other devices of relevance to separation science. This tutorial should spur additional interest in the area and promote new ideas on how to employ 3D printers to create novel materials.

 Topics:  Introduction to 3D printing and main printing techniques of relevance to separation science; impact of 3D printing in the fabrication of stationary phases, column devices, and ancillary elements for preparative and analytical chromatography; current challenges and future opportunities.

 Lecturer:

Dr. Dimartino is a Senior Lecturer at the Institute for Bioengineering at the University of Edinburgh. He completed his PhD at the University of Bologna on membrane-based separations in the biopharmaceutical industry (2009), followed by an academic position at the University of Christchurch, New Zealand, where he explored new separation methods for the production of biologics. He now employs 3D printing methods for the fabrication of devices with perfectly ordered internal morphology, with applications encompassing bioseparations, biocatalysis and heat transfer. Entertaining science communication video here. Interview on the future of 3D printing and chromatography here.

Monday Afternoon Free Vendor Technical WorkshopsMonday, June 1, 2020

Must pre-register at the sponsor's booth to attend; light meal will be provided

12:20-1:50 PM Three Innovative Advancements for Accelerated Process Development and Maryland Suite Improved Biomanufacturing Outcomes“COLUMBIA” Sponsored by GE Healthcare Life Sciences2nd floor Must pre-register at the booth of GE Healthcare Life Sciences by Monday @ 10:40 AM

12:20-1:50 PM TBAMaryland Suite “FREDERICK” Sponsored by Nouryon/Kromasil2nd floor Must pre-register at the booth of Nouryon/Kromasil by Monday @ 10:40 AM

12:20-1:50 PM Implementation of an Open Access Mass Directed Semi-preparative HPLC System Maryland Suite to Support Drug Discovery Efforts“ANNAPOLIS” Sponsored by Agilent Technologies2nd floor Must pre-register at the booth of Agilent Technologies by Monday @ 10:40 AM

12:20-1:50 PM Leveraging Protein Purification Utilizing Advanced Properties of ConvecdiffMaryland Suite Membrane Adsorbers“BALTIMORE” Sponsored by Sartorius Stedim Biotech2nd floor Must pre-register at the booth of Sartorius Stedim Biotech by Monday @ 10:40 AM

Tuesday Afternoon Free Vendor Technical WorkshopsTuesday, June 2, 2020

Must pre-register at the sponsor's booth to attend; light meal will be provided

12:20-1:50 PM TBAMaryland Suite “COLUMBIA” Sponsored by Purolite Life Sciences2nd floor Must pre-register at the booth of Purolite Life Sciences by Tuesday @ 10:40 AM

12:20-1:50 PM Purification of Viral Vectors and VaccinesMaryland Suite Sponsored by Bio-Rad Laboratories“FREDERICK” Must pre-register at the booth of Bio-Rad Laboratories by Tuesday @ 10:40 AM2nd floor

12:20-1:50 PM TBAMaryland Suite “ANNAPOLIS” Sponsored by KNAUER2nd floor Must pre-register at the booth of KNAUER by Tuesday @ 10:40 AM

Preliminary List of Sponsors, Exhibitors, Media Partners

AbbVieAgilent TechnologiesAmerican LaboratoryAmerican Pharmaceutical ReviewAMPAC Fine ChemicalsAnalytical ScientistAnnals of Chromatography and Separation TechniquesAstraZenecaBioanalysis ZoneBiocompareBioprocessing JournalBio-Rad LaboratoriesBristol-Myers SquibbChromatographia-SpringerChromatography TodayCompare NetworksDAISO Fine Chem USAemp BiotechGenentech

Genetic Engineering & Biotechnology NewsGE Healthcare Life SciencesGlaxoSmithKlineInternational LabmateITOCHU Chemicals AmericaJSR Life SciencesKNAUERLab BulletinLab CompareLCGCNouryon/KromasilPfizerPharmaceutical OutsourcingPurolite Life SciencesSartorius Stedim BiotechSeparation Science JournalSEPIATECShimadzu Scientific InstrumentsYMC America, Inc.

Preliminary List of Corporate and Conference Sponsors

Gold Sponsors

Silver Sponsors

Bronze Sponsors

Best Poster CompetitionPoster presentations are a very important component of the PREP Symposia. In order to acknowledge their contribution to the field and high standards of the symposium, awards will be offered to distinguish the best poster contributions at PREP 2020.

Posters will be evaluated on the basis of scientific content, clarity of presentation, and layout. Posters co-authored by members of the Scientific and Industrial Advisory Committees or by judges are eligible only if the main author and presenter of the poster is not a member on the above committees. Posters authored or co-authored by members of the Organizing Committee or judges are not eligible for Best Poster Awards. However, should these posters be considered of sufficient quality to be among the top prize-winning entries, they will be given an Honorable Mention. The Poster Judging Committee will have final say in the selection of the Prize Winners. At least two committee members will read each poster and top posters will be read by at least four committee members. If a poster author does not want his/her poster considered for a poster award, they must notify the Symposium Manager at the Symposium Registration Desk before 11:00 AM on Tuesday, June 2. 

Presentation of awards to winners of the Best Poster Competition will take place at 10:10 AM on Wednesday before the mid-morning break. The winners are encouraged to be present, but it is not mandatory to be present to win. 

PREP Symposium Conference History

1985 Washington DC 2005 Philadelphia, PA

1986 Washington DC 2006 Baltimore, MD

1987 Washington DC 2007 Baltimore, MD

1989 Washington DC 2008 San Jose, CA

1991 Washington DC 2009 Philadelphia, PA

1993 Washington DC 2010 Philadelphia, PA

1994 Washington DC 2011 Cambridge, MA

1995 Washington DC 2012 Cambridge, MA

1996 Washington DC 2013 Boston, MA

1997 Washington DC 2014 Boston, MA

1998 Washington DC 2015 Philadelphia, PA

1999 San Francisco, CA 2016 Philadelphia, PA

2000 Washington DC 2017 Philadelphia, PA

2001 Washington DC 2018 Baltimore, MD

2002 Washington DC 2019 Baltimore, MD

2003 San Francisco, CA

2004 Baltimore, MD

Sunday, May 31, 20209:00 AM - 1:00 PM Workshop 1 on Fundamentals of Preparative Chromatography for Maryland Suite Biomolecules by Batch and Continuous Processes“ANNAPOLIS” See details and pricing at PREPsymposium.org. Open to conference and 2nd floor non-conference participants. Must pre-register to attend.

2:00 PM - 6:00 PM Workshop 2 on Fundamentals of Preparative Chromatography for Maryland Suite Purification of Small and Intermediate Size APIs by Batch “ANNAPOLIS” Chromatography, SMB, and SFC2nd floor See details and pricing at PREPsymposium.org. Open to conference and

non-conference participants. Must pre-register to attend.

1:00 PM - 5:30 PM Exhibitor Registration Only – badge required to set up boothLocation: Constellation Ballroom, 2nd floor

6:00 PM - 7:30 PM Symposium Registration Open for ConfereesLocation: Constellation Ballroom, 2nd floor

6:00 PM - 7:30 PM Grand Opening of the Exhibition & Welcome ReceptionLocation: Constellation Ballroom, 2nd floorReady to meet a few new faces at this year’s meeting? Or just reconnect with your colleagues? The Welcome Reception is the perfect opportunity to do so! Conference attendees will enjoy a welcome reception of wine and light hors d’oeuvres. Open to all conference participants; conference name badge is required for entry.

 

Monday, June 1, 20207:30 AM - 5:10 PM Symposium Registration Open - Location: Constellation Ballroom, 2nd floor

8:00 AM - 7:30 PM Exhibition Open - Location: Constellation Ballroom, 2nd floor

Monday Welcome and Opening RemarksLocation: Constellation Ballroom C/D, 2nd floor

8:30 AM - 8:40 AM WELCOME AND OPENING REMARKSGiorgio Carta, University of Virginia, Charlottesville, VA, USA

1. Monday Keynote Session: Regulatory and Data Science PerspectivesSession Chair: Lois Ann Beaver, LAB EnterprisesLocation: Constellation Ballroom C/D, 2nd floor

8:40 AM ICH Q13 Continuous Manufacturing of Drug Substances and Drug Products – Where are we with this Guidance? Ganapathy Mohan, Merck, West Point, PA, USA

9:10 AM Managing and Filing Changes to Regulated Chromatography Processes. Duncan Low 1 , Brian Hubbard2, 1Claymore Biopharm LLC, Culpeper, VA, USA; 2CMC Bioprocess Consulting LLC, Scottsdale, AZ, USA

9:40 AM Smart Digital Solutions for USP and DSP to Master Bioengineering Challenges Towards Industry 4.0 In Biopharma. Fabian Feidl 1 , Michael Sokolov1, Harini Narayanan2, Martin Luna2, Nico Cruz1, Massimo Morbidelli2, Alessandro Butté1, 1DataHow AG, Zurich, SWITZERLAND; 2ETH Zurich, Zurich, SWITZERLAND

10:10 AM - 10:40 AM Mixer in Constellation Exhibition Hall, 2nd floor

2. Monday Keynote Session: Industrial Case Studies in Protein ChromatographySession Chairs: Alan Hunter and Timothy Pabst, AstraZenecaLocation: Constellation Ballroom C/D, 2nd floor

10:40 AM A Mechanistic Understanding of Fouling and Ligand Degradation for Protein A Resin. Kevin Potter, James Angelo, Xuankuo Xu, Sanchayita Ghose, Bristol-Myers Squibb, Devens, MA, USA

11:00 AM Accelerating Process Development by Moving from the Tool Box to the Hardware Store. Melody Trexler-Schmidt, Michael Chinn, Jessica Yang, Genentech a Member of the Roche Group, South San Francisco, CA, USA

11:20 AM Toward a Full Assessment of Process Robustness during Process Characterization: Linking of Unit Operations to Understand the Propagation of Process and Quality Attribute Variability. Siddharth Parimal, Kathryn Meintel, Amy Pushman, Joseph Boyer, John Peterson, Gerald Terfloth, Andre Dumetz, Antonio Ubiera, GlaxoSmithKline, King of Prussia, PA, USA

11:40 AM One is the Loneliest Number that You’ll Ever Do: The Power of Dual Salt Hydrophobic Interaction Chromatography Separations. Ashley Sacramo, Pfizer, Andover, MA, USA

12:00 PM A Science-based Safety Risk Assessment Strategy and Downstream Process Clearance Potential for Low Molecular Weight Process-related Impurities in Recombinant Monoclonal Antibody Therapeutics. Haibin Luo 1 , Yuling Li1, David Robbins1, Simone Nicholson1, Brad Stanard1, Sheau-Chiann Wang1, Guoling Xi1, Andrew Teasdale2, 1AstraZeneca, Gaithersburg, MD, USA; 2AstraZeneca, Macclesfield, UK

Monday, June 1, 2020

Monday Mixer in the Constellation Exhibition HallLocation: Constellation Ballroom, 2nd floor Mixer includes light lunch at 12:20-1:50 PM

12:20 PM - 3:20 PM Break, Exhibits, Mixer, Posters

Monday Free Vendor WorkshopsMust pre-register at the sponsor's booth to attend; light lunch will be provided

12:20-1:50 PM Three Innovative Advancements for Accelerated Process Development and Maryland Suite Improved Biomanufacturing Outcomes“COLUMBIA” Sponsored by GE Healthcare Life Sciences2nd floor Must pre-register at the booth of GE Healthcare Life Sciences by Monday @ 10:40 AM

12:20-1:50 PM TBAMaryland Suite “FREDERICK” Sponsored by Nouryon/Kromasil2nd floor Must pre-register at the booth of Nouryon/Kromasil by Monday @ 10:40 AM

12:20-1:50 PM Implementation of an Open Access Mass Directed Semi-preparative HPLC System Maryland Suite to Support Drug Discovery Efforts“ANNAPOLIS” Sponsored by Agilent Technologies2nd floor Must pre-register at the booth of Agilent Technologies by Monday @ 10:40 AM

12:20-1:50 PM Leveraging Protein Purification Utilizing Advanced Properties of ConvecdiffMaryland Suite Membrane Adsorbers“BALTIMORE” Sponsored by Sartorius Stedim Biotech2nd floor Must pre-register at the booth of Sartorius Stedim Biotech by Monday @ 10:40 AM

MONDAY POSTER SESSION 1Poster Session Chair: TBALocation: Constellation Ballroom, 2nd floor

1:50 PM - 3:20 PM POSTER SESSION 1 - Sponsored by Bristol-Myers Squibb

Monday, June 1, 20203A. Monday Parallel Session: Mechanisms and Fundamentals - ISession Chair: TBALocation: Constellation Ballroom C, 2nd floor

3:20 PM Effect of Pressure Increase on Macromolecules’ Adsorption in Ion-exchange Chromatography. Anja Kristl, Miha Luksic, Matevz Pompe, Ales Podgornik, Faculty for Chemistry and Chemical Technology University of Ljubljana, Ljubljana, SLOVENIA

3:40 PM A Biophysical Approach for Probing Selectivity Trends in the Purification of Bispecific Antibodies using Multimodal Chromatography. Siddharth Parasnavis 1 , Matthew Aspelund2, Steven Cramer1, 1Howard P. Isermann Department of Chemical & Biological Engineering Rensselaer Polytechnic Institute, Troy, NY, USA; 2Purification Process Sciences Bioprocess Development, AstraZeneca, Gaithersburg, MD, USA

4:00 PM Multicomponent Adsorption as a Hindrance of Fab Fragment Purification. Alejandro Santiago Leon1, Clemens Schimek1, Cecile Brocard2, Gerald Striedner1, Rainer Hahn 1 , 1BOKU Vienna, Vienna, AUSTRIA; 2Boehringer Ingelheim RCV GmbH & Co KG, Vienna, AUSTRIA

4:20 PM Origins of Protein Adsorption Behaviour with Stimuli-responsive Ion Exchange Resins. Milton T.W. Hearn, Monash University, Clayton, AUSTRALIA

4:40 PM - 5:10 PM Mixer in Constellation Exhibition Hall, 2nd floor

3B. Monday Parallel Session: Stationary Phases - ISession Chair: TBALocation: Constellation Ballroom D, 2nd floor

3:20 PM QbD: Studying the Interplay between Resin Variability and Process Parameters. Peter Hagwall, Gunnar Malmquist, GE, Uppsala, SWEDEN

3:40 PM New Developments in Protein A Affinity Chromatography. Hans Johansson, Mark Hicks, Patrick Gilbert, Purolite, Llantrisant, UK

4:00 PM Viral Clearance Efficiency Assessment at Early Phase of Process Development: A Case Study using a Mixed-Mode Resin. Xuemei He 1 , Akunna Iheanacho2, Coral Fulton2, Irene Chen1, William Rushton1, Katelyn Pritchard2, Jenifer Dean2, Kaye Peden3, Sreyry Schaerdel2, Erin Reynolds2, 1Bio-Rad Laboratories, Hercules, CA, USA; 2Texcell North America Inc., Frederick, MD, USA; 3Texcell North America Inc., Frederick, MD, USA

4:20 PM Optimization of the Selection of Adsorbents using Grey Box Models. Martin Leipnitz, Andreas Biselli, Niklas Scholl, Andreas Jupke, RWTH Aachen University, Aachen, GERMANY

4:40 PM - 5:10 PM Mixer in Constellation Exhibition Hall, 2nd floor

Monday, June 1, 2020

4A. Monday Parallel Session: Mechanisms and Fundamentals - IISession Chair: TBALocation: Constellation Ballroom C, 2nd floor

5:10 PM Estimation of Adsorption Isotherm Parameters for Binary Mixtures using an Extended Elution by Characteristic Point (ECP) Method. Ivana Mutavdzin, Andreas Seidel-Morgenstern, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, GERMANY

5:30 PM Theory and Design of Chromatofocusing pH Gradients using Julia-based Mechanistic and Machine-learning Models. Yang Liu 1 , Sevda Deldari1, Hui Guo2, Chittoor R. Narahari3, Ronald Bates4, Jay M. West5, Kathleen Trejo5, Ryan Swanson6, Derek Yau Chung Choy5, Sanchayita Ghose5, Douglas D. Frey1, 1University of Maryland Baltimore County, Baltimore, MD, USA; 2Shimadzu Scientific Instruments, Columbia, MD, USA; 3Moderna Therapeutics, Cambridge, MA, USA; 4Bristol-Myers Squibb, East Syracuse, NY, USA; 5Bristol-Myers Squibb, Devens, MA, USA; 6 Lifecore Biomedical, Chaska, MN, USA

5:50 PM Modelling of Preparative Ion-pair Chromatography. Jörgen Samuelsson1, Marek Lesko1, Krzysztof Kaczmarski2, Torgny Fornstedt 1 , 1Karlstad University, Karlstad, SWEDEN; 2Rzeszów University of Technology, Rzeszów, POLAND

6:10 PM Comparison of Batch and Column Data for Estimating Model Parameters in Ion-exchange Chromatography. Vijesh Kumar 1 , John Welsh2, Michael Rauscher2, Joe Boerma2, Chris Williams3, Jessica Yang4, Steven Cramer5, Abraham Lenhoff1, 1University of Delaware, Newark, DE, USA; 2Merck and Co., Kenilworth, NJ, USA; 3Genentech Inc., Penzberg, GERMANY; 4Genentech Inc., South San Francisco, CA, USA; 5Rensselaer Polytechnic Institute, Troy, NY, USA

6:30 PM - 7:30 PM Vendor Reception & Mixer in Constellation Exhibition Hall, 2nd floorThis networking event provides opportunities to connect with fellow participants and view new product launches, check out innovative products, explore ground-breaking technologies, and discuss challenges and solutions with experts in the booths. Open to all conference participants; conference name badge is required for entry.

Monday, June 1, 2020

4B. Monday Parallel Session: Stationary Phases - IISession Chair: TBALocation: Constellation Ballroom D, 2nd floor

5:10 PM Affinity Tag-based Development and Manufacturing Platform for Non-platform Proteins. Nico Lingg 1 , Andreas Fischer1, Gerald Striedner2, Chris Oostenbrink2, Rainer Schneider3, Matthias Berkemeyer4, Alois Jungbauer2, 1ACIB, Vienna, AUSTRIA; 2BOKU, Vienna, AUSTRIA; 3University of Innsbruck, Innsbruck, AUSTRIA; 4Boehringer Ingelheim RCV, Vienna, AUSTRIA

5:30 PM Novel Peptide Ligands for the Purification of CRISPR Cas9 Nucleases. Kevin Day, Raphael Prodromou, Sahand Saberi-Bosari, Ashton Lavoie, Mohammad Omary, Connor Market, Adriana San Miguel, Stefano Menegatti, North Carolina State University, Raleigh, NC, USA

5:50 PM Can We use Silica Resin for Preparative Biomolecule Purification? Stefan Rauwolf, Sebastian Patrick Schwaminger, Sonja Berensmeier, Technical University of Munich, Munich, GERMANY

6:10 PM Development of an Efficient Purification Process for a Recombinant E. coli Protein. Andrew Lees 1 , Samson Grebnatsae1, William Rushton2, Chelsea Pratt2, 1Fina BioSolutions, Rockville, MD, USA; 2Bio-Rad Laboratories, Hercules, CA, USA

6:30 PM - 7:30 PM Vendor Reception & Mixer in Constellation Exhibition Hall, 2nd floorThis networking event provides opportunities to connect with fellow participants and view new product launches, check out innovative products, explore ground-breaking technologies, and discuss challenges and solutions with experts in the booths. Open to all conference participants; conference name badge is required for entry.

Tuesday, June 2, 2020

Tuesday Tutorial

7:00 AM - 8:25 AM Practical Concepts on Process Characterization and Validation ofMaryland Suite Biopharmaceuticals based on QbD Principles“COLUMBIA” See details and pricing at PREPsymposium.org. Open to conference and2nd floor non-conference participants. Must pre-register to attend.

7:30 AM - 5:10 PM Symposium Registration Open

8:00 AM - 5:10 PM Exhibition Open

5. Tuesday Keynote Session: Continuous Chromatography: New Approaches, New Applications Session Chairs: Kathleen Mihlbachler, YMC Process Technologies and Andreas Seidel-Morgenstern, Max-Planck Institute, MagdeburgLocation: Constellation Ballroom C/D, 2nd floor

8:30 AM Scale-up Considerations for Commercial Scale SMB Separations. Olivier Dapremont, Ryan Woods, AMPAC Fine Chemicals, Rancho Cordova, CA, USA

8:50 AM Extended Relay Simulated Moving-bed Chromatography. Jose Mota, Tiago Santos, LAQV FCT-UNL, Caparica, PORTUGAL

9:10 AM Continuous Two-zone Ligand-assisted Displacement Chromatography for the Purification of REEs from a Complex Ternary Mixture. David Harvey, Yi Ding, Zihao Liang, Nien-Hwa Linda Wang, Purdue University, West Lafayette, IN, USA

9:30 AM New Design Strategy of Continuous Chromatographic Separation Processes for ‘Center-cut’ Separations. Ju Weon Lee, Max Planck Institute for Dynamics of Technical Systems, Magdeburg, GERMANY

9:50 AM Efficient Development of Advanced Chromatographic Processes using the Modular Framework ‘CADET-Process’. Malte Kaspereit, Johannes Schmölder, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, GERMANY

10:10 AM - 10:40 AM Mixer in Constellation Exhibition Hall, 2nd floor

Tuesday, June 2, 2020

6. Tuesday Keynote Session: Continuous and Integrated Biochromatography Session Chair: Sunitha Kandula, MerckLocation: Constellation Ballroom C/D, 2nd floor

10:40 AM Whole Process Residence Time Distribution Modeling: The Key to Batching in a Continuous World. Nuno Pinto 1 , Adrian Gospodarek1, Matthew Flamm2, Mark Brower1, 1Merck & Co., Inc., Kenilworth, NJ, USA; 2Merck & Co., Inc., West Point, PA, USA

11:00 AM Showcase an Integrated Continuous Process for an Fc Fusion Molecule with a Predictive Control Strategy Applying a Digital Twin Approach. Dominik Mittergradnegger, Martin Purtscher, Katerina Petrushevska-Seebach, Johannes Scheiblauer, Takeda, Vienna, AUSTRIA

11:20 AM From Batch to Continuous Processing: Purification of a Bioactive Peptide by Means of Multicolumn Countercurrent Solvent Gradient Purification (MCSGP). Martina Catani 1 , Chiara De Luca1, Simona Felletti1, Giulio Lievore1, Alessandro Buratti1, Antonio Ricci2, Marco Macis2, Walter Cabri2, Massimo Morbidelli3, Alberto Cavazzini1, 1University of Ferrara, Ferrara, ITALY; 2Fresenius Kabi iPSUM, Villadose (Rovigo), ITALY; 3ETH Zurich, Zurich, SWITZERLAND

11:40 AM Process Characterization of Capture Chromatography by Periodic Counter Current Operation or by Repeated Cyclic Operation. Chyi-Shin Chen, Noriko Yoshimoto, Shuichi Yamamoto, Yamaguchi University, Ube, JAPAN

12:00 PM Using Automated Batch to Achieve Continuous Operations for mAbs. Van Leang, HJB, Hangxhou, CHINA

Tuesday Mixer in the Constellation Exhibition HallLocation: Constellation Ballroom, 2nd floor Mixer includes light lunch at 12:20-1:50 PM

12:20 PM - 3:20 PM Break, Exhibits, Mixer, Posters

Tuesday Free Vendor WorkshopsMust pre-register at the sponsor's booth to attend; light lunch will be provided

12:20-1:50 PM TBAMaryland Suite “COLUMBIA” Sponsored by Purolite Life Sciences2nd floor Must pre-register at the booth of Purolite Life Sciences by Tuesday @ 10:40 AM

12:20-1:50 PM Purification of Viral Vectors and VaccinesMaryland Suite Sponsored by Bio-Rad Laboratories“FREDERICK” Must pre-register at the booth of Bio-Rad Laboratories by Tuesday @ 10:40 AM2nd floor

12:20-1:50 PM TBAMaryland Suite “ANNAPOLIS” Sponsored by KNAUER2nd floor Must pre-register at the booth of KNAUER by Tuesday @ 10:40 AM

Tuesday, June 2, 2020

TUESDAY POSTER SESSION 2Poster Session Chair: TBALocation: Constellation Ballroom, 2nd floor

1:50 PM - 3:20 PM POSTER SESSION 2 - Sponsored by Bristol-Myers Squibb

7A. Tuesday Parallel Session: Modeling Chromatographic ProcessesSession Chair: TBALocation: Constellation Ballroom C, 2nd floor

3:20 PM Integrating High-throughput Screening with Mechanistic Modeling for Rapid Development of Multimodal Chromatographic Processes. Scott Altern1, Jessica Yang2, Chris Williams2, John Welsh3, Jake Klockowski1, Steven Cramer 1 , 1Department of Chemical and Biological Engineering Rensselaer Polytechnic Institute, Troy, NY, USA; 2Purification Development Genentech, South San Francisco, CA, USA; 3Biologics Process Development and Commercialization Merck & Co., Inc., Kenilworth, NJ, USA

3:40 PM Gaussian-processes Can Accelerate the Calculation of Chromatographic Parameters in A Multidimensional Design Space. Ronald Jäpel, Johannes Buyel, Fraunhofer IME, Aachen, GERMANY

4:00 PM Modeling and Simulation of Ion-exchange in Bio-processes – Illustrations from Industrial Biotech to Biopharma. Hector Osuna 1 , David Pfister2, Lucrece Nicoud2, Karen-Vanessa Gonzalez2, Roger-Marc Nicoud2, 1YPSO-FACTO, Lyon, FRANCE; 2YPSO-FACTO, Nancy, FRANCE

4:20 PM Assembly, Simulation and Optimization of a More Flexible and General Chromatographic Process for Peptide and Protein Purification. Tiago Santos, Raquel Serra, José Paulo Mota, FCT-UNL, Caparica, PORTUGAL

4:40 PM - 5:10 PM Mixer in Constellation Exhibition Hall, 2nd floor

7B. Tuesday Parallel Session: Stationary Phases - IIISession Chair: TBALocation: Constellation Ballroom D, 2nd floor

3:20 PM The Power of Enhanced Selectivity Chromatography Resins for Fc Carrying Proteins. Romas Skudas, Annika Holzgreve, MilliporeSigma, Darmstadt, GERMANY

3:40 PM Providing Purification Solutions for Challenging Bio-therapeutics - A Case Study: Development of a Custom Carbohydrate Affinity Resin. Jing Zhu 1 , Scott Zobbi1, Orjana Terova1, Moira Lynch1, Jessica de Rooij2, 1Thermo Fisher Scientific, Bedford, MA, USA; 2Thermo Fisher Scientific, Leiden, NETHERLANDS

4:00 PM Purification of Antibody Fragments with Amsphere™ A3 Protein A Chromatography Resin. Kristi Haskins 1 , Masayoshi Nagaya2, Gerald Platteau3, Guido Ströhlein3, 1JSR Life Sciences, Durham, NC, USA; 2JSR Life Sciences, Sunnyvale, CA, USA; 3JSR Life Sciences, Leuven, BELGIUM

4:20 PM Wettable C18 Stationary Phase for Loading 100% Aqueous Feed Solution in Preparative Chromatography. Fredrik Lime, Anneli Hermansson, Therese Tran, Joakim Hogblom, Kromasil by Nouryon, Bohus, SWEDEN

4:40 PM - 5:10 PM Mixer in Constellation Exhibition Hall, 2nd floor

Tuesday, June 2, 2020

8A. Tuesday Parallel Session: Alternatives to Column Chromatography Session Chair: TBALocation: Constellation Ballroom C, 2nd floor

5:10 PM Evaluation of Novel Flocculants and Filtration Technologies to Debottleneck High-density Cell Culture Harvest Clarification. Johanna Gervais, AbbVie Bioresearch Center, Worcester, MA, USA

5:30 PM Inline Harvest Adjustment and Salt Precipitate Removal in a Continuous Biomanufacturing Process. Dhiral Shah, Emily Davenport, Russell Bigelow, Matthew Stundtner, Jiuyi Lu, Kevin Brower, Sanofi, Framingham, MA, USA

5:50 PM Extraction and Purification of Proteins from Biotechnology by Centrifugal Partition Chromatography. Luc Marchal 1 , Sébastien Chollet2, Jean-Hugues Renault3, 1University of Nantes - GEPEA Laboratory, Saint-Nazaire, FRANCE; 2Capacites SAS, Nantes, FRANCE; 3University of Reims - ICMR, Reims, FRANCE

6:10 PM Centrifugal Partition Chromatography at Industrial-scale: Concept, Instrumentation and Applications. Robert Orkenyi, Laszlo Ovari, Kristof Gazda, Mario Nacsa, Erika T Jantyikne, Eszter Blanar, Dora Rutterschmid, Laszlo Lorantfy, Árpád Konczol, RotaChrom Technologies LLC, Dabas, HUNGARY

6:30 PM Pause

7:30 - 10:30 PM CONFERENCE GALA DINNER CRUISE (ticket required)

8B. Tuesday Parallel Session: Continuous ChromatographySession Chairs: Kathleen Mihlbachler, YMC Process Technologies and Andreas Seidel-Morgenstern, Max-Planck Institute, MagdeburgLocation: Constellation Ballroom D, 2nd floor

5:10 PM Continuous Separation in Biopharmaceutical Manufacturing. Karsten Keller, Roman Hillebrand, Anand Krishnamurthy, Nitto Denko Avecia Inc., Milford, MA, USA

5:30 PM Continuous Chromatography of Synthetic Peptides. Ralf Eisenhuth, Bachem AG, Basel, SWITZERLAND

5:50 PM Potential Application of Simulated Moving Bed (SMB) Process for Xylitol Purification in Industrial Processes. Yannick Krauke, Svea Stephan, Matthias Lübbert, Kate Monks, KNAUER Wissenschaftliche Geräte GmbH, Berlin, GERMANY

6:10 PM Success Story of an Integrated and Intensified Continuous Downstream Process. Thomas Flouquet 1 , Alpesh Patel2, 1Novasep, Pompey, FRANCE; 2Novasep, Boothwyn, PA, USA

6:30 PM Pause

7:30 - 10:30 PM CONFERENCE GALA DINNER CRUISE (ticket required)

Wednesday, June 3, 2020

Wednesday Tutorial

7:00 AM - 8:25 AM 3D Printing in Separation ScienceMaryland Suite See details and pricing at PREPsymposium.org. Open to conference and“COLUMBIA” non-conference participants. Must pre-register to attend.2nd floor

7:45 AM - 4:45 PM Symposium Registration Open

9. Wednesday Keynote Session: Preparative Chromatography in Drug and Natural Products Development and Manufacture Session Chair: Olivier Dapremont, AMPAC Fine ChemicalsLocation: Constellation Ballroom C/D, 2nd floor

8:30 AM Scaling Up Recycling Chromatography for the Identification of Nearly Co-eluting Impurities in Drug Samples. Fabrice Gilles Ernest Gritti 1 , Michael Fogwill1, Martin Gilar1, Qi Yan2, Frank Riley2, 1Waters Corporation, Milford, MA, USA; 2Pfizer, Groton, CT, USA

8:50 AM Combining Continuous Enantioselective Chromatography and Enzymatic Racemization. Isabel Harriehausen, Heike Lorenz, Andreas Seidel-Morgenstern, Max-Planck-Institute Magdeburg, Magdeburg, GERMANY

9:10 AM Expanding the Reach of Sub/Supercritical Fluid Chromatography via AmmoniumHydroxide in Water-rich Modifiers. Jimmy DaSilva, Jinchu Liu, Raffeal Bennett, Imad Haidar Ahmad, Erik Regalado, Merck & Co., Inc., Rahway, NJ, USA

9:30 AM Latest Developments of a Sustainable Chromatography Technique: Supercritical Fluid Chromatography for Achiral and Chiral Separations in the Pharma and Cannabis Industries. Gerard Rosse, Arrival Discovery LLC, San Diego, CA, USA

9:50 AM Scaling up the Purification and Remediation of Hemp Extracts from Grams to Kilosper Day. John Van Antwerp, Jason Lee, Jaci Cole, Thar Process, Pittsburgh, PA, USA

10:10 AM Presentation of Awards to Winners of the Best Poster Competition

10:20 AM - 10:40 AM Break

Wednesday, June 3, 2020

10. Wednesday Session: Chromatography ModelingSession Chair: Chen Wang, AbbVieLocation: Constellation Ballroom C/D, 2nd floor

10:40 AM Real-time Monitoring and Model-based Prediction of Product Purity and Quantity throughout Downstream Processing of Biopharmaceuticals. Dominik Sauer 1 , Michael Melcher2, Nicole Walch3, Theresa Scharl-Hirsch4, Friedrich Leisch2, Alois Jungbauer4, Astrid Duerauer4, 1Austrian Centre of Industrial Biotechnology, Vienna, AUSTRIA; 2BOKU Vienna, Vienna, AUSTRIA; 3Boehringer-Ingelheim RCV, Vienna, AUSTRIA; 4BOKU Vienna / Austrian Centre of Industrial Biotechnology, Vienna, AUSTRIA

11:00 AM Modeling and Simulation of Uncommon Antibody Elution Behavior under High Load Conditions in Cation Exchange Chromatography by using a Modified SMA Isotherm. Felix Seelinger1, Felix Wittkopp2, Thomas von Hirschheydt2, Andreas Schaubmar2, Christian Frech 1 , 1University of Applied Sciences Mannheim, Mannheim, GERMANY; 2Roche Diagnostics GmbH Pharma Research and Early Development (pRED) Large Molecule Research (LMR) Roche Innovation Center Munich, Penzberg, GERMANY

11:20 AM Model-based Strategies Towards Protein A Resin Lifetime Optimization and Supervision. Massimo Morbidelli 1 , Fabian Feidl1, Martin Luna1, Matevz Podobnik1, Sebastian Vogg1, James Angelo2, Kevin Potter2, Elenore Wiggin2, Xuankuo Xu2, Sanchayita Ghose2, Zheng Jian Li2, Alessandro Butté1, 1ETH Zurich, Zurich, SWITZERLAND; 2Bristol-Myers Squibb, Devens, MA, USA

11:40 AM Model-based Procedure for Design and Scale up of a Chromatographic Capture Step for a Clarified Bacterial Homogenate. Michał Kołodziej1, Bartłomiej Filip1, Dominik Georg Sauer2, Jürgen Beck2, Wojciech Kazimierz Marek1, Rainer Hahn2, Alois Jungbauer2, Astrid Dürauer2, Wojciech Piątkowski1, Dorota Antos 1 , 1Rzeszow University of Technology (RUT), Rzeszow, POLAND; 2University of Natural Resources and Life Sciences Vienna, Vienna, AUSTRIA

12:00 PM Towards Industrial Applicability of Colloidal Ion-exchange Adsorption Isotherms. Till Briskot 1 , Tobias Hahn2, Thiemo Huuk2, Jürgen Hubbuch3, 1Karlsruhe Institute of Technology (KIT)/GoSilico GmbH, Karsruhe, GERMANY; 2GoSilico GmbH, Karlsruhe, GERMANY; 3Karlsruhe Institute of Technology (KIT), Karlsruhe, GERMANY

12:20 PM - 1:30 PM Pause

Wednesday, June 3, 2020

11. Wednesday Session: Monoliths and Membrane ChromatographySession Chair: TBALocation: Constellation Ballroom C/D, 2nd floor

1:30 PM New Materials and Morphologies for 3D Printed Stationary Phases. Simone Dimartino, Mariachiara Conti, Struan Hattersley, Qihao Jiang, Sulaiman Sarwar, Ursula Simone, The University of Edinburgh, Edinburgh, UK

1:50 PM Enabling Transition to Single Use Polishing AEX Chromatography using Advanced Materials. Matthew Peters, Jennifer Heitkamp, Alexei Voloshin, 3M, St. Paul, MN, USA

2:10 PM High Productivity Process Chromatography Using Novel “CONVECDIFF” Membranes to Enable Membrane-based Antibody Purification Processes. Adrian Ley, Volkmar Thom, Florian Taft, Patrick Adametz, Sartorius Stedim Biotech GmbH, Goettingen, GERMANY

2:30 PM Modeling and Simulation of mAb Charge Variant Separation: Evaluation of Mass Transport Differences in Membrane and Column Chromatography. Jan Hedrich 1 , Alina Wulff1, Romas Skudas2, Michael Schulte2, Christian Frech1, 1University of Applied Sciences Mannheim, Mannheim, GERMANY; 2Merck KGaA, Darmstadt, GERMANY

2:50 PM Digital Twins for Downstream Processing of Therapeutic Proteins. Rushd Khalaf, Millipore Sigma, Bedford, MA, USA

3:10 PM - 3:25 PM Pause

Wednesday, June 3, 2020

12. Wednesday Session: Novel Approaches to Virus and High Value Proteins PurificationSession Chair: TBALocation: Constellation Ballroom C/D, 2nd floor

3:25 PM Chromatographic Purification of Influenza Virus-like Particles from Insect Cell. Katrin Reiter 1 , Patricia Aguilar1, Alois Jungbauer2, 1acib, Vienna, AUSTRIA; 2BOKU, Vienna, AUSTRIA

3:45 PM A Scalable Adeno Associated Virus Production Process, from Cell Culture to Purified Bulk. Asa Hagner McWhirter, Ann-Christin Magnusson, Eva Blanck, Robert Magnusson, Hans Blom, Daphne Areskoug, Anna Mattsson, Greta Hultberg, Åsa Lagerlöf, Mats Lundgren, GE Healthcare, Uppsala, SWEDEN

4:05 PM Leveraging Membrane Adsorbers for Efficient Purification of Virus-based Therapeutics. Carsten Voss, Ana-Raquel Fortuna, Amelie Boulais, Sartorius Stedim Biotech, Goettingen, GERMANY

4:25 PM Magnetic Separation for High Value Proteins. Sonja Berensmeier, Sebastian Schwaminger, Paula Fraga-Garcia, Yasmin Kaveh Baghbaderani, Eva Kolitzki, Technical University of Munich, Munich, GERMANY

4:45 PM ECP - New Approach to Multistep Downstream Purification Strategies. Karsten Fjarstedt, Anna Heijbel, Lars Haneskog, Bio-Works Sweden AB, Uppsala, SWEDEN

5:05 PM - 5:15 PM CLOSING REMARKS, Giorgio Carta, University of Virginia, Charlottesville, VA, USA

5:15 PM - 6:15 PM FAREWELL RECEPTIONThe Farewell Reception takes place immediately following the Closing session on Wednesday. Before heading out, join us to bid farewell to fellow conference participants.Location: Constellation Ballroom, 2nd floor