web-duke-shares-01.oit.duke.edu · Web viewhief cells = wedge-shaped, dark cells, secretory...
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RJ Edwards Lab 5& 6: GI system Normal Body Notes 10/18/18 GI Layering: Start with Slide 32! Mucosa : Epithelium Lamina Propria: loose CT Muscularis Mucosae Submucosa : dense irregular CT Meissner’s plexus: ENS Submucosal glands Muscularis Externa : Skeletal m. at start and end smooth muscle in most of GI I nner ci rcular layer, O uter lo ngitudinal layer Auerbach’s plexus between layers: ENS Serosa (DICT + mesothelium) or Adventitia (dense to fatty CT) Esophagus: Tube with GI Layering: Mucosa, Submucosa, Muscularis externa, Adventitia o Mucosa = Stratified squamous non-keratinized epithelium Lamina propria = thin layer of loose, cellular CT Muscularis mucosae = longitudinal smooth muscle, thick in proximal esophagus o Submucosa = dense irregular CT with seromucous glands , ducts with stratified cuboidal to squamous epithelium (Meissner’s plexus) o Muscularis externa 2 well-defined layers, inner circular, outer longitudinal Define orientation of section with respect to tube Muscle type varies: skeletal→mix→smooth muscle Define region: upper, middle or lower third Auerbach’s plexus between layers o Adventitia = loose, fatty CT. May be lost in prep. (Serosa after diaphragm) Longitudinal folds, slightly collapsed lumen Look for neighbors (trachea, aorta, stomach) Page 1 of 5 Figure 1. GI layering, our slide 32
Transcript of web-duke-shares-01.oit.duke.edu · Web viewhief cells = wedge-shaped, dark cells, secretory...
RJ Edwards Lab 5& 6: GI systemNormal Body Notes 10/18/2018 4:46:00 PM
GI Layering: Start with Slide 32! Mucosa:
Epithelium Lamina Propria: loose CT Muscularis Mucosae
Submucosa: dense irregular CT Meissner’s plexus: ENS Submucosal glands
Muscularis Externa: Skeletal m. at start and end smooth muscle in most of GI I nner circular layer, Outer longitudinal layer Auerbach’s plexus between layers: ENS
Serosa (DICT + mesothelium) or Adventitia (dense to fatty CT)
Esophagus: Tube with GI Layering: Mucosa, Submucosa, Muscularis externa, Adventitia
o Mucosa = Stratified squamous non-keratinized epithelium Lamina propria = thin layer of loose, cellular CT Muscularis mucosae = longitudinal smooth muscle, thick in proximal esophagus
o Submucosa = dense irregular CT with seromucous glands , ducts with stratified cuboidal to squamous epithelium (Meissner’s plexus)
o Muscularis externa 2 well-defined layers, inner circular, outer longitudinal Define orientation of section with respect to tube Muscle type varies: skeletal→mix→smooth muscle Define region: upper, middle or lower third Auerbach’s plexus between layers
o Adventitia = loose, fatty CT. May be lost in prep. (Serosa after diaphragm) Longitudinal folds, slightly collapsed lumen Look for neighbors (trachea, aorta, stomach)
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Figure 1. GI layering, our slide 32Figure 1. GI layering, our slide 32Figure 1. GI layering, our slide 32Figure 1. GI layering, our slide 32Figure 1. GI layering, our slide 32Figure 1. GI layering, our slide 32Figure 1. GI layering, our slide 32
RJ Edwards Lab 5& 6: GI systemNormal Body Notes 10/18/2018 4:46:00 PM
Stomach: Tube with GI Layering: Mucosa, Submucosa, Muscularis externa, Serosa
o Mucosa = Wide-bore pits and narrow, coiled, tubular glands Surface epithelium = simple columnar mucous surface cells with mucous cup Glands define region of stomach:
C orpus/funduso C hief cells = wedge-shaped, dark cells, secretory granules, basal nucleio P arietal cells = round/triangular, ~20 µm, pale round nucleus, with nucleoluso Mucous neck cells
P yloric = some parietal cells, mostly mucous cells, look for duodenum Cardiac = no chief, no parietal, all mucous cells, look for esophagus
Enteroendocrine cells with secretory granules facing lamina propria, part of ENSo Submucosa: dense, irregular CT, blood vessels, nerves, (Meissner’s plexus)o Muscularis externa:
3 layers, difficult to distinguish Inner oblique, middle circular, outer longitudinal Auerbach’s plexus
o Serosa Folds = rugae, distensible
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RJ Edwards Lab 5& 6: GI systemNormal Body Notes 10/18/2018 4:46:00 PM
Small Intestine Tube with GI Layering: Mucosa, Submucosa, Muscularis externa, Serosa
o Mucosa = Villi & Crypts of Lieberkühn (glands) Epithelium =
o Enterocytes = simple columnar cells with brush border and o Goblet cellso Paneth cells with eosinophilic secretory granules in cryptso Enteroendocrine cells with secretory granules facing lamina propria, part of ENS
Rich lamina propria, may see occasional lymph nodules Many nodules = Peyer’s patches (only in ileum!) Thin muscularis mucosae, may see 2 layers
o Submucosa: dense, irregular CT, blood vessels, nerves, Meissner’s plexus Submucosal glands = Brunner’s glands (only in duodenum!)
o Muscularis externa: 2 clear layers Inner circular, outer longitudinal Auerbach’s plexus
o Serosa Folds = plicae circulares Identify region:
o Many lymph nodules = Peyer’s patches ⇒ ileumo Brunner’s glands ⇒ duodenumo No Brunner’s glands, no Peyer’s patches ⇒ jejunum or ileum away from Peyer’s patches
Large Intestine: Mucosa
o Straight-bore crypts o Epithelium
Enterocytes Goblet cells Enteroendocrine cells with secretory
granules facing lamina propria, part of ENS
o Rich lamina propriao Muscularis mucosae (may see 2 layers)
Submucosa: dense, irregular CT, blood vessels, nerves, (Meissner’s plexus)
Muscularis externao May see teniae coli = thickening of outer,
longitudinal layer into 3 distinct bands Serosa
Ano-rectal junction:
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Teniae Coli (TC) in the large intestine.Teniae Coli (TC) in the large intestine.Teniae Coli (TC) in the large intestine.Teniae Coli (TC) in the large intestine.Teniae Coli (TC) in the large intestine.Teniae Coli (TC) in the large intestine.Teniae Coli (TC) in the large intestine.
RJ Edwards Lab 5& 6: GI systemNormal Body Notes 10/18/2018 4:46:00 PM
See transition from simple columnar to stratified squamous Lose muscularis mucosae Eccrine and apocrine sweat glands in submucosa Serosa becomes adventitia Muscularis externa gains skeletal muscle Hair follicles
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