WBC notes
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LeukocytesWhite Blood CellsBiology Three19-3
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WBCsFive Types Classified according to the presence or absence of granules and the staining characteristics of their cytoplasm.Leukocytes appear brightly colored in stained preparations, they have a nuclei and are generally larger in size than RBCs.
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Type of WBCsGranulocyteshave large granules in their cytoplasm
NeutrophilsEosinophilsBasophils
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Types of WBCsAgranulocytesdo not have granules in their cytoplasm
LymphocytesMonocytes
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GranuloctyesNeutrophilsStain light purple with neutral dyesGranules are small and numerouscourse appearanceSeveral lobes in nucleus65% of WBC countHighly mobile/very activeDiapedesisCan leave blood vessels and enter tissue spacePhagocytosis (eater), contain several lysosomes (janitor)
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GranulocytesEosinophilsLarge, numerous granulesNuclei with two lobes2-5% of WBC countFound in lining of respiratory and digestive tractsImportant functions involve protections against infections caused by parasitic worms and involvement in allergic reactionsSecrete anti-inflammatory substances in allergic reactions
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GranulocytesBasophilsLeast numerous--.5-1%DiapedesisCan leave blood vessels and enter tissue spaceContain histamineinflammatory chemical
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AgranulocytesLymphocytesSmallest WBCLarge nuclei/small amount of cytoplasmAccount for 25% of WBC countTwo typesT lymphocytesattack an infect or cancerous cell, B lymphocytesproduce antibodies against specific antigens (foreign body)
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AgranulocytesMonocytesLargest of WBCsDark kidney bean shaped nucleiHighly phagocytic
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WBC NumbersDoctors look at WBC numbers.If number goes up there is some kind of infection and surgery might be needed.Clinics will count the number of WBCs in a blood sample, this is called differential count.A decrease in the number of white blood cells is leukopeniaAn increase in the number of white blood cells is leukocytosis.
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Formation of WBCsLeukocytes are formed in the red marrow of many bones.They can also be formed in lymphatic tissue.They live for about 13-20 days.