WAY TO FIND HALT PROSTATE CANCER

PROGRESS COMPOUND STOPS GROWTH OF TUMOR

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• SCIENTISTS HAVE DISCOVERED A NEW TREATMENT THAT COULD HALT THE PROGRESSION OF PROSTATE CANCER.RESEARCHERS AT THE UNIVERSITY OF BRISTOL, THE UNIVERSITY OF NOTTINGHAM AND THE UNIVERSITY OF THE WEST OF ENGLAND (UWE) HAVE IDENTIFIED A COMPOUND THAT INHIBITS THE ACTIVITY OF A MOLECULE WHICH HELPS CANCER CELLS TO GROW AND MULTIPLY .

• SCIENTISTS BELIEVE THAT THE NEW TREATMENT, WHICH HAS BEEN TESTED SUCCESSFULLY ON MICE, COULD HALT THE GROWTH OF TUMOURS IN PATIENTS WITH PROSTATE CANCER.

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CONTD..

• THE FINDINGS SHOW THAT TARGETING A MOLECULE CALLED SRPK1 COULD STOP PROGRESSION OF THE CANCER. SRPK1 PLAYS A VITAL ROLE IN `ANGIOGENESIS' -AN ESSENTIAL PROCESS THROUGH WHICH TUMOURS ARE ABLE TO FORM BLOOD VESSELS AND OBTAIN NECESSARY NUTRIENTS TO FUEL THEIR GROWTH.

• THIS PROCESS IS MAINLY REGULATED BY THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) WHICH CAN ACTIVATE OR INHIBIT VESSEL FORMATION DEPENDING ON HOW THE GENE IS CONTROLLED BY A CELLULAR PROCESS CALLED `ALTERNATIVE SPLICING'. BY ANALYSING SAMPLES OF HUMAN PROSTATE CANCER, RESEARCHERS OBSERVED THAT SRPK1 INCREASES AS THE CANCER GETS MORE AGGRESSIVE.

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• SEBASTIAN OLTEAN FROM THE UNIVERSITY OF BRISTOL SAID, “WE REASONED THAT INHIBITION OF SRPK1 ACTIVITY COULD STOP CANCER PROGRES SION. INDEED, WE SHOW IN THIS PAPER THAT IF WE DECREASE SRPK1 LEVELS IN PROSTATE CANCER CELLS, OR IN TUMOURS GRAFTED INTO MICE, WE ARE ABLE TO SWITCH VEGF SPLICING AND THEREFORE INHIBIT TUMOUR VASCULATURE AND GROWTH.“

• RESEARCHERS SHOWED THAT DRUGS KNOWN AS SPHINX COMPOUNDS DESIGNED TO INHIBIT SPECIFICALLY THE ACTIVITY OF SRPK1 ARE ABLE TO DECREASE TUMOUR GROWTH IN A MOUSE MODEL OF PROSTATE CANCER WHEN GIVEN THREE TIMES WEEKLY BY INJECTIONS.

• DAVID BATES, CO-AUTHOR FROM THE UNIVERSITY OF NOTTINGHAM, SAID, “OUR RESULTS POINT TO A NOVEL WAY OF TREATING PROSTATE CANCER AND MAY HAVE WIDER IMPLICATIONS TO BE USED IN SEVERAL TYPES OF CANCERS.“

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