W. Mark Saltzman

Yale Universitymark.saltzman@yale.edu

http://saltzman.eng.yale.edu/research.html

Biomaterials, Drug Delivery, and Tissue Engineering

Biomaterials for Controlled Release of Drugs

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PLGA nanoparticles loaded with camptothecin (CPT). Scale bar: 500 nm.

Sawyer, Saucier-Sawyer, Booth, Liu, Patel, Piepmeier, Saltzman (2011)

Brem, Colvin, Langer, Saltzman, and Guilford Pharmaceuticals (1990-2006): Gliadel ® approved for glioblastoma multiforme (1996)

Sawyer, Saucier-Sawyer, Booth, Liu, Patel, Piepmeier, Saltzman (2011)

Nanoparticles Loaded with Genetic Material

DNA: Pharm Res 16:1300, 1999; J Cont Rel 129:66, 2008;Nanomedicine 6:334, 2010;Nature Materials 11:82, 2012

siRNA: Nature Materials 8:526, 2009; Biomaterials 32:6194, 2011; Biomaterials 33:583, 2012

Peptide Nucleic Acids: Molecular Therapy 19:172, 2011Molecular Pharmaceutics 9:1481, 2012 Zhou, Patel, Fu, Bertram, and Saltzman (2012)

Tissue Engineering: Transplantable materials that turn into vascularized tissues

Human endothelial cells

Polymer microparticles loaded with proteins that stimulate blood vessel growth

Suspend in a Collagen Gel

Implant into a location in the body where new blood vessels are needed

With Jordan Pober, Immunobiology