Vwr Calibration Service

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VWR Calibration & Metrology Services

VWR Sales 1.800.932.5000 vwr.com

Environmentally-Controlled Lab Locations

With multiple calibration facilities throughout the United States and Puerto Rico,VWR serves nearly every major metropolitan area of the country. All facilities arebuilt to world-class standards in terms of environmental stability and control.Utilizing state-of-the-art measurement standards, VWR offers direct traceability tothe National Institute of Standards and Technology (NIST) and compliance withISO/IEC 17025, GLP/GMP, ISO, NCCLS, CAP, CLIA standards, and 21 CFR.

Experienced Calibration & Metrology Teams

VWR's Calibration & Metrology leadership teams have a combined experience ofwell over 100 years, spanning industries and markets such as pharmaceutical,biotech, aeronautical, automotive, government, military, and environmental. Thebackground and experience of the VWR team provides you the confidence thatyour requirements are understood and that our services are executed properly andexpeditiously.

For over a century, VWR has been a leader in lab supply distribution. The companythat you know and trust for sourcing your lab equipment and supplies now offersa full suite of calibration, metrology, and validation services. Now you can rely onVWR to help maintain control of and track your lab's assets, while extending thelife of your lab's equipment.

A Leader in Lab

Distribution…

A Leader in

Calibration and

Metrology Services

Header

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Call the VWR

Calibration &

Metrology Services

team today at

1-888-793-2300

Save Time and Money with One-Stop Shopping for All YourCalibration and Technical Services

You've always known VWR as your one-stop shop for lab equipment and supplies,and with a full spectrum of technical disciplines, VWR now offers this same one-stop shopping capability for servicing your instruments and equipment.

Whether you need routine calibrations for pipettors, thermometers, or balances,or you require more advanced mass standards services, VWR is here to help. VWRoffers a full portfolio of Calibration & Metrology Services to ensure your compliance with imposed requirements, enable good business practices, and coverall your preventative maintenance needs.

Delivering Results You Can Count On

VWR's processes include a quality manual written around ISO/IEC 17025, well-documented standard operating procedures, calculated uncertainty budgets, highlyskilled technicians, and state-of-the-art facilities that serve as a foundation to helpyour lab improve accuracy, increase productivity, ensure compliance, mitigate risk,and ultimately reduce your overall expenditures on these services.

Performance Beyond Measure

VWR Calibration & Metrology Services 1.888.793.2300

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Mass Calibration Services


VWR's mass calibration laboratoryhas incorporated state-of-the-art pro-tocols and techniques, ensuring highaccuracy and traceability.

Standardi zing on a 3-in-1 weighingdesign for all mass calibrations yieldsthe best results with the lowestmeasurement uncertainties.

Detailed multi-page certificates aredesigned to meet your regulatory documentation needs.

1. All pertinent customer information2. Date the standards were received3. Date of the weight calibration4. Date that the certificate was issued5. Standards that are used during the

calibration process6. Accuracy class7. True mass (also known as mass in

a vacuum)8. Conventional mass values9. "as found" data

10. "as left" data11. Mass corrections for each weight12. Uncertainty of the measurement

process13. Environmental conditions during

the test14. NIST traceability information15. Construction of the mass standards16. Density of the weights17. Definition of commonly used

metrology terms

VWR uses multiple high precision mass comparators, covering all existing ASTMand OIML classes, including OIML Class E1 and ASTM Class O. VWR's MassMetrology Center offers calibrations for every weight range from 0.1mg to 50kg.Most of the comparators used have auto-handling devices, which helps improveturnaround time while yielding the lowest uncertainties. Our custom softwareprogram has been specifically designed to incorporate air buoyancy correctionswhile simultaneously ensuring the accuracy of the data collection process by eliminating transposition and transcription errors. VWR's metrologists are highlyskilled and well trained in mass calibrations through intensive internal and external training programs. All calibrations are directly traceable to the NationalInstitute of Standards and Technology (NIST).

Each certificate contains:

5VWR Calibration & Metrology Services 1.888.793.2300

Balance Services

Ultra-Micro BalancesThese balances usually have a readabilityranging from 0.1 to 1µg with capacitiesthat normally do not exceed 6g.

Semi-Micro BalancesThese balances usually have a readabil-ity ranging from 0.01 to 1mg withcapacities that normally do not exceed500g.

Toploader and Torsion Balances These balances usually have a readabilityranging from above 1g with capacitiesthat normally exceed 500g.

VWR services a wide variety of weighing instruments, including ultra-micro andmicro balances, toploaders, torsion scales, and knife-edge balances. All servicesare performed on-site at your facility. Using time-tested methodologies in compliance with standards that govern gravimetric measurement systems, ourdocumentation and our testing protocols are as follows:

The calibration and servicing protocols include all of the following for all balances:• Both "as found" and "as left" data• Cornerload test• Repeatability test• Linearity test• Releveling the balance• Cleaning the draft shield, housing, weighing pan, weighing chamber, and door tracks• "Blowing out" the weighing cell to ensure accurate and consistent readings• Adjusting the instrument using a weight matching procedure

6 VWR Sales 1.800.932.5000 vwr.com

Volumetric (Liquid Handling) Calibration Services


VWR has the capability to calibrate (either gravimetrically or photometrically)and/or verify a wide array of volumetric instruments including pipettors, titrators,bottle-top dispensers, syringes, and repeaters across every volume range from0.1µL to 200mL. Volumetric calibration services are offered either at your facilityor at one of our state-of-the-art, environmentally controlled laboratories. Ourtechnicians are highly skilled and have been trained and certified by several different pipettor manufacturing companies.

Gravimetric calibrations are performed on 5-, 6- or 7-place balances and mass comparators, depending on the volume measured. There is a direct relationshipbetween weight and volume, so the volume dispensed can be precisely calculated.All gravimetric calibrations are directly traceable to NIST.

Photometric or colorimetric calibrations are performed with the finest spectrophotometers available. This method involves the analysis of volumes ofdiluted dye in a cell of known pathlength. According to the Beer-Lambert law, ifa beam of monochromatic radiation passes through a homogeneous solution of equal pathlength, the absorbance measured is proportional to the dye concentration. So if VWR pipettes an unknown volume of dye into a known volume of diluent and measures the resulting dye concentration photometrically,we can then accurately calculate the volume dispensed.

VWR uses genuinemanufacturer's

parts, and servicesall brands

and models.

Volumetric (Liquid Handling) Calibration Services

VWR's humidity calibration services span a wide variety of humidity instrumentation, including chart recorders, data loggers, hygrothermographs,sensors, hygrometers, humidity generators, and dew point instrumentation.

VWR uses a Thunder Scientific humidity generator for all humidity calibrations performed in our metrology centers. This system uses a "two-pressure" and"two-temperature" humidity generation process developed by NIST. This designproduces high precision humidity determinations ideal for instrument calibrationand evaluation.

Laboratory capabilities are 10% to 95% (+/- 0.7%) Relative Humidity. Temperaturerange covered is 0°C to 70°C (+/- 0.06°C). A dew point reference standard is alsoused for the calibration of humidity generators, dew point hygrometers, and otherhumidity standards for temperatures between -40°C and 90°C.

The Edgetech RH CAL system is employed for all calibrations performed on-site or in any one of our calibration facilities. RH CAL is a microprocessor-based,programmable humidity calibration system that is versatile enough to be used inour calibration labs or out in the field performing on-site NIST traceable humiditycalibrations. The system offers the highest accuracy available for both relativehumidity and ambient temperature, controlling both temperature and relativehumidity independently; therefore, we are not limited to performing calibrations atthe surrounding ambient temperature.

The device utilizes an Optical Chilled Mirror (OCM) primary measurement technique for traceability and feedback control, making this a standalone, portablehumidity calibration system. Probes or devices are inserted through access portson the chamber cover for a simple and accurate comparison calibration to achilled mirror primary standard!

8 VWR Sales 1.800.932.5000 vwr.com

Humidity Calibration Services


VWR offers a comprehensive temperature calibration service utilizing advancedequipment and training designed to provide the lowest possible measurementuncertainties.

VWR's temperature capabilities encompass most RTD's, thermistors,thermocouples, bimetals, and liquid-in-glass thermometers. Fixed-point calibrations can be performed at one of our metrology centers or comparison calibrations at any of our calibration facilities. Services are performed using DirectComparison (-100ºC to 600ºC), Simulation (-250ºC to 2300ºC), or Infrared (35ºC to600ºC) methods.

• RTD's - All RTD calibrations are performed using the comparison method againsta highly accurate primary standard. All calibrations are referenced back to theITS-90 temperature scale.

• Thermistors - All thermistor calibrations are performed using the comparisonmethod against a highly accurate primary standard. All calibrations are refer-enced back to the ITS-90 temperature scale.

• Thermocouples - All thermocouple calibrations are performed using the comparison method against a highly accurate primary standard or by simulation.All calibrations are referenced back to the ITS-90 temperature scale.

• Bimetals - All bimetal calibrations are performed using the comparison methodagainst a highly accurate primary standard. All calibrations are referenced backto the ITS-90 temperature scale.

• Liquid-in-Glass Thermometers - All liquid-in-glass thermometer calibrations areperformed using the comparison method against a highly accurate primary stan-dard. All calibrations are referenced back to the ITS-90 temperature scale.

VWR has standardized on Fluke* and Hart* equipment in order to provide a testuncertainty ratio (TUR) of at least 4:1. This equipment also provides us with flexibility in terms of being able to perform the calibrations on-site at your facilityor off-site at a VWR location.

Temperature Calibration Services

Calibrations can beperformed on-site at your facility or

off-site at a VWR location.

VWR's metrology staff and calibrationtechnicians have extensive training andexperience in pressure calibrations andoffer standard and customized servicesthat satisfy all of your quality require-ments. Calibration services cover awide variety of pressure instrumentsincluding gauges, transducers, transmit-ters, calibrators, monitors, and pressurecontrollers.

Pressure calibrations performed in aVWR calibration lab utilize either theDH Instrument PPC3 pressure calibra-tion system, the Druck* DPI 600 seriespressure calibrator, or the Ruska 7215xipressure controller. Calibrations performed in the field utilize Fluke*,Ashcroft*, or Heiss* pressure modules.

The PPC3 pressure calibrator isequipped with individually character-ized quartz reference pressure transducer (Q-RPT) modules thatincrease precision and reduce measurement uncertainties. Thisdevice allows us to instantaneouslyswitch and thereby calibrate in eithergauge, absolute, or compound gaugemodes with no pressure discontinuity.

VWR has a tieredservice offering to

precisely meet yourquality requirements.

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Pressure Calibration Services



VWR employs the Vibrograf* Timometer 4500, the same standard utilized by manymajor pharmaceutical and biotech companies, to calibrate various timing devices.This device provides digital rate measurement and some diagnostic information on all timing instrumentation. The standard is equipped with threesensor microphones for unmatched acoustical pickup and it has the ability to testall frequencies. The portability of this device allows us to perform this calibrationon-site at your facility or off-site at ours.

Our calibration documentation provides both "as found" and "as left" data sets,the standard that is used during the calibration process, tolerance of the devicesunder test (DUT), environmental conditions, and direct traceability to NIST.

Other Calibration Services

VWR offers many other metrology and calibration services including electrical,dimensional, pH, conductivity, specific gravity, and density. These services coverinstrumentation such as multimeters, calipers, pH meters, hydrometers, vortexers,centrifuges, incubators, clamp meters, and conductivity devices.

Each standard is methodically selected to provide the best possible calibrationservice with the lowest measurement uncertainties. All documentation isdesigned with compliance and traceability to meet the most demanding qualityprotocols and standards.

Timer and Stopwatch Services

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Consulting and Technical Training Services


• Balance fundamentals and metrology• Preventative maintenance and calibration of precision balances• Calibration quality system overview• The components of a quality calibration• Ergonomics and proper pipetting techniques• Realizing the ITS-90 scale

VWR's metrology staff serve as consultants to help you with your specific metrology, calibration, or validation needs. Our experts also conduct seminars ona variety of topics. For your convenience, the seminars can be held at your site orat our training center. Some of the most frequently requested seminars include:


Validation Services

VWR can offer project management support, resources and personnel for:

• Development or Improvement of Master Validation Plans, ValidationPrograms / Systems, and Change Control Systems

• Preparation and Execution of Process Performance Qualifications, CleaningValidations, and Product Validations (PPQ and PV)

• Preparation and Execution of Laboratory Instrument and EquipmentQualifications

• IQ, OQ, PQ, and Computer Validation (21 CFR Part 11)• Analytical Method Optimization and Troubleshooting• Analytical Methodology Transfer• Validation of Laboratory Test Methods• Preparation and Execution of Sterilization Validation• Pharmaceutical Process and Product Validation• New Product Transfer Services• Process Optimization• GAP Analysis• Development of Cleaning Methods for Actives or Surfactants• Process and Laboratory Instrument / Equipment Qualifications (IQ, OQ, PQ)

for Chemical and Microbiological Applications• GLP and GMP Auditing Services for Analytical or Manufacturing

Environments

VWR's validation department has assembled a consultant group inseveral operational areas to assure a comprehensive managementapproach for the most challenging manufacturing and regulatoryenvironments focusing on pharmaceuticals and medical device manufacturing.

From computer validations to microbiology assessments, fromprocess performance qualifications to laboratory test method validations, from statistical process control to process audits anddocumentation, we have all the bases covered.

For Product Sales Call: 1.800.932.5000Prices, product appearance and specifications are current at the time of printing,subject to change without notice. Availability for certain products may be limited byfederal, state, provincial or local licensing requirements. All prices are in U.S. dollarsunless otherwise noted. Offers valid in USA, void where prohibited by law or company policy, while supplies last. Visit vwr.com to view our privacy policy andadditional disclaimers.

Items identified by a daisy(*) are equipment produced by their respective manufacturers; the names used are trademarks and/or trade names owned by thosemanufacturers. Equipment designations are current at the time of printing andmodel descriptions or manufacturers are subject to change without notice.©2006 VWR International, Inc. All rights reserved. Printed in U.S.A.

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