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Transcript of Volume 18 Endocrine–Related...
Endocrine – Related
Cancer
Volume 18
ISSN 1351–0088 (print)ISSN 1479–6821 (online)
Editor-in-Chief
Associate Editors
Editorial Board
Founding Editor
Statistical Advisor
C EngCleveland, OH, USA
C L ClarkeSydney, Australia
D BallBaltimore, MD, USA
R ClarkeWashington, DC, USA
D El-AshryMiami, FL, USA
O GimmLinkoping, Sweden
C A LangeMinneapolis, MN, USA
C J McCabeBirmingham, UK
B RobinsonSydney, Australia
J TrapmanRotterdam, Netherlands
M van de VijverAmsterdam, Netherlands
R WeigelIowa City, IA, USA
M XingBaltimore, MD, USA
V H T JamesLondon, UK
H van den BergCoventry, UK
A B GrossmanLondon, UK
N BundredManchester, UK
A Di CristofanoNew York, NY, USA
R EliseiPisa, Italy
B HaugenAurora, CO, USA
S K LibuttiNew York, NY, USA
S OesterreichHouston, TX, USA
P SantistebanMadrid, Spain
W TilleyAdelaide, Australia
P WebbBrisbane, Australia
B WiedenmannBerlin, Germany
K KnudsenPhiladelphia, PA, USA
F ClaessensLeuven, Belgium
M DicklerNew York, NY, USA
P GhoshSacramento, CA, USA
W W de HerderRotterdam, Netherlands
D MarshSt Leonards, Australia
M C PikeLos Angeles, CA, USA
M SantoroNaples, Italy
R VigneriCatania, Italy
F WeberEssen, Germany
J WimalasenaKnoxville, TN, USA
Endocrine-Related Cancer is published by
BioScientifica (Limited by Guarantee).
The agent for distribution is Portland Press, PO Box 32,
Commerce Way, Whitehall Industrial Estate,
Colchester CO2 8HP, UK.
Copyright q2011 by the Society for Endocrinology.
Typeset by OKS Prepress Services, Chennai, India.
Printed by Latimer Trend & Company Ltd, Plymouth, UK.
Printed on acid-free paper.
Endocrine – Related
Cancer
Volume contents
Number 1 $ February 2011
EDITORIAL: Something old, somethingnew
Charis Eng E1
COMMENTARY: Adrenomedullin andcalcitonin gene-related peptide receptors inendocrine-related cancers: opportunitiesand challenges
Debbie L Hay, Christopher S Walker& David R Poyner
C1–C14
REVIEW: Clinical significance of estrogenreceptor phosphorylation
Leigh C Murphy, Srinivas V Seekallu& Peter H Watson
R1–R14
The tyrosine kinase inhibitor ZD6474blocks proliferation of RET mutantmedullary thyroid carcinoma cells
Donata Vitagliano, Valentina DeFalco, Anna Tamburrino, SabrinaColuzzi, Giancarlo Troncone, GennaroChiappetta, Fortunato Ciardiello,Giampaolo Tortora, James A Fagin,Anderson J Ryan, Francesca Carlomagno& Massimo Santoro
1–11
FSH inhibits ovarian cancer cell apoptosisby up-regulating survivin and down-regulating PDCD6 and DR5
Yan Huang, Hongyan Jin, Yingtao Liu,Jiayi Zhou, Jingxin Ding, Kwai WaCheng, Yinhua Yu & Youji Feng
13–26
Single photon emission computedtomography imaging for temporaldynamics of thyroidal and salivaryradionuclide accumulation in 17-allyamino-17-demothoxygeldanamycin-treated thyroid cancer mouse model
Yu-Yu Liu, Michael P Brandt, Daniel HShen, Richard T Kloos, Xiaoli Zhang &Sissy M Jhiang
27–37
2011
Volume 18
ISSN 1351–0088 (print)ISSN 1479–6821 (online)
Expression of neuregulin 4 splice variantsin normal human tissues and prostate cancerand their effects on cell motility
Nandini V L Hayes, Edith Blackburn,Mary M Boyle, Graham A Russell, TeresaM Frost, Byron J T Morgan & William JGullick
39–49
Ki-67 index, tumor differentiation, andextent of liver involvement are independentprognostic factors in patients with livermetastases of digestive endocrinecarcinomas
O Hentic, A Couvelard, V Rebours,M Zappa, S Dokmak, P Hammel,F Maire, D O’Toole, P Levy,A Sauvanet & P Ruszniewski
51–59
Expression of connective tissue growthfactor and IGF1 in normal and neoplasticgastrointestinal neuroendocrine cells andtheir clinico-pathological significance
Gregory A Kaltsas, Janet L Cunningham,Sture E Falkmer, Lars Grimelius &Apostolos V Tsolakis
61–71
Mutation analysis of HIF prolylhydroxylases (PHD/EGLN) in individualswith features of phaeochromocytoma andrenal cell carcinoma susceptibility
Dewi Astuti, Christopher J Ricketts,Rasheduzzaman Chowdhury, Michael AMcDonough, Dean Gentle, Gail Kirby,Susanne Schlisio, Rajappa S Kenchappa,Bruce D Carter, William G Kaelin Jr,Peter J Ratcliffe, Christopher J Schofield,Farida Latif & Eamonn R Maher
73–83
The miR-200 family controls b-tubulin IIIexpression and is associated withpaclitaxel-based treatment response andprogression-free survival in ovarian cancerpatients
Susanna Leskela, Luis J Leandro-Garcıa,Marta Mendiola, Jorge Barriuso, LucıaInglada-Perez, Ivan Munoz, BeatrizMartınez-Delgado, Andres Redondo,Javier de Santiago, Mercedes Robledo,David Hardisson &Cristina Rodrıguez-Antona
85–95
Catecholamine metabolomic and secretoryphenotypes in phaeochromocytoma
Graeme Eisenhofer, Karel Pacak,Thanh-Truc Huynh, Nan Qin, GennadyBratslavsky, W Marston Linehan,Massimo Mannelli, Peter Friberg, StefanK Grebe, Henri J Timmers, Stefan RBornstein & Jacques W M Lenders
97–111
Distinctive functions of p160 steroidreceptor coactivators in proliferation of anestrogen-independent, tamoxifen-resistantbreast cancer cell line
Sudipan Karmakar, Estrella A Foster,Julia K Blackmore & Carolyn L Smith
113–127
AZD1152 negatively affects the growth ofanaplastic thyroid carcinoma cells andenhances the effects of oncolytic virusdl922-947
Silvana Libertini, Antonella Abagnale,Carmela Passaro, Ginevra Botta, SaraBarbato, Paolo Chieffi & GiuseppePortella
129–141
www.endocrinology-journals.org
Increased uptake of [123I]meta-iodobenzylguanidine, [18F]fluorodopamine,and [3H]norepinephrine in mousepheochromocytoma cells and tumors aftertreatment with the histone deacetylaseinhibitors
Lucia Martiniova, Shiromi M Perera,Frederieke M Brouwers, Salvatore Alesci,Mones Abu-Asab, Amanda F Marvelle,Dale O Kiesewetter, David Thomasson,John C Morris, Richard Kvetnansky,Arthur S Tischler, James C Reynolds,Antonio Tito Fojo & Karel Pacak
143–157
Do histological, immunohistochemical,and metabolic (radioiodine andfluorodeoxyglucose uptakes) patterns ofmetastatic thyroid cancer correlate withatient outcome?
D Deandreis, A Al Ghuzlan,S Leboulleux, L Lacroix, J P Garsi,M Talbot, J Lumbroso, E Baudin,B Caillou, J M Bidart & M Schlumberger
159–169
A pilot genome-wide association studyshows genomic variants enriched in thenon-tumor cells of patients with well-differentiated neuroendocrine tumors ofthe ileum
Kyle M Walsh, Murim Choi, Kjell Oberg,Matthew H Kulke, James C Yao,Chengqing Wu, Magdalena Jurkiewicz,Ling-I Hsu, Susanne M Hooshmand,Manal Hassan, Eva T Janson, Janet LCunningham, Evan Vosburgh, Richard SSackler, Richard P Lifton, Andrew TDeWan & Josephine Hoh
171–180
mTOR expression and activity patterns ingastroenteropancreatic neuroendocrinetumours
Atsuko Kasajima, Marianne Pavel, SilviaDarb-Esfahani, Aurelia Noske, AlbrechtStenzinger, Hironobu Sasano, ManfredDietel, Carsten Denkert, ChristophRocken, Bertram Wiedenmann &Wilko Weichert
181–192
Gene expression signature discriminatessporadic from post-radiotherapy-inducedthyroid tumors
Catherine Ory, Nicolas Ugolin, CelineLevalois, Ludovic Lacroix, BernardCaillou, Jean-Michel Bidart, MartinSchlumberger, Ibrahima Diallo, Florentde Vathaire, Paul Hofman,Jose Santini, Bernard Malfoy &Sylvie Chevillard
193–206
Number 2 $ April 2011
REVIEW: Transcriptome analysis ofadrenocortical cancers: from molecularclassification to the identification of newtreatments
Bruno Ragazzon, Guillaume Assie &Jerome Bertherat
R15–R27
www.endocrinology-journals.org
REVIEW: Persistent disease and recurrencein differentiated thyroid cancer patientswith undetectable postoperative stimulatedthyroglobulin level
C Nascimento, I Borget,A Al Ghuzlan, D Deandreis,L Chami, J P Travagli, D Hartl,J Lumbroso, C Chougnet, L Lacroix,E Baudin, M Schlumberger& S Leboulleux
R29–R40
Inhibition of the Rho GTPase, Rac1,decreases estrogen receptor levels and is anovel therapeutic strategy in breast cancer
Adena E Rosenblatt, Maria Ines Garcia,Leah Lyons, Yingqiu Xie, CarolMaiorino, Laurent Desire, JoyceSlingerland & Kerry L Burnstein
207–219
Decreased progesterone receptor isoformexpression in luteal phase fallopian tubeepithelium and high-grade serouscarcinoma
Alicia A Tone, Carl Virtanen, PatriciaA Shaw & Theodore J Brown
221–234
IGF1 and risk of additional breast cancer inthe WHEL study
Wael K Al-Delaimy, Shirley W Flatt,Loki Natarajan, Gail A Laughlin,Cheryl L Rock, Ellen B Gold,Bette J Caan, Barbara A Parker& John P Pierce
235–244
Androgen receptor levels are upregulatedby Akt in prostate cancer
Susan Ha, Rachel Ruoff, Nicole Kahoud,Thomas F Franke & Susan K Logan
245–255
Combination of trastuzumab and letrozoleafter resistance to sequential trastuzumaband aromatase inhibitor monotherapies inpatients with estrogen receptor-positive,HER-2-positive advanced breast cancer:a proof-of-concept trial (SAKK 23/03)
D Koeberle, T Ruhstaller, L Jost,O Pagani, K Zaman, R von Moos,C Oehlschlegel, S Crowe, C Pilop,B Thuerlimann & on behalf of the SwissGroup for Clinical Cancer Research(SAKK)
257–264
Association of genetic polymorphisms inESR2, HSD17B1, ABCB1, and SHBG geneswith colorectal cancer risk
J Sainz, A Rudolph, R Hein,M Hoffmeister, S Buch, W von Schonfels,J Hampe, C Schafmayer, H Volzke,B Frank, H Brenner, A Forsti,K Hemminki & J Chang-Claude
265–276
The novel Raf inhibitor Raf265 decreasesBcl-2 levels and confers TRAIL-sensitivityto neuroendocrine tumour cells
Kathrin Zitzmann, Enrico de Toni,Janina von Ruden, Stephan Brand,Burkhard Goke, Rudiger P Laubender& Christoph J Auernhammer
277–285
Expression of somatostatin receptors,dopamine D2 receptors, noradrenalinetransporters, and vesicular monoaminetransporters in 52 pheochromocytomasand paragangliomas
Alexandru Saveanu, Mihaela Muresan,Catherine De Micco, David Taieb,Anne-Laure Germanetti, Frederic Sebag,Jean-Francois Henry, Laurent Brunaud,Alain Enjalbert, Georges Weryha &Anne Barlier
287–300
www.endocrinology-journals.org
Number 3 $ June 2011
COMMENTARY: mTOR inhibition, apotential novel approach for bronchialcarcinoids
Mei Dong & James C Yao C15–C18
REVIEW: Novel insights on imaging sexhormone-dependent tumourigenesis in vivo
Balaji Ramachandran, Alessia Stell,Luca Maravigna, Adriana Maggi& Paolo Ciana
R41–R51
REVIEW: Tumor-induced osteomalacia William H Chong, Alfredo A Molinolo,Clara C Chen & Michael T Collins
R53–R77
REVIEW: A critical evaluation of the roleof aromatase inhibitors as adjuvant therapyfor postmenopausal women with breastcancer
Thierry Petit, Patrick Dufour& Ian Tannock
R79–R89
Histone deacetylase inhibitors upregulateRap1GAP and inhibit Rap activity inthyroid tumor cells
Xiaoyun Dong, Christopher Korch& Judy L Meinkoth
301–310
Coxsackie and adenovirus receptor is atarget and a mediator of estrogen action inbreast cancer
David Vindrieux, Ludovic Le Corre,Jer-Tsong Hsieh, Raphael Metivier,Pauline Escobar, Andres Caicedo,Madly Brigitte & Gwendal Lazennec
311–321
Overexpression of the natural antisensehypoxia-inducible factor-1a transcript isassociated with malignantpheochromocytoma/paraganglioma
P N Span, J U Rao,S B J Oude Ophuis, J W M Lenders,F C G J Sweep, P Wesseling,B Kusters, F H van Nederveen,R R de Krijger, A R M M Hermus& H J L M Timmers
323–331
Therapeutically activating RB:reestablishing cell cycle control inendocrine therapy-resistant breast cancer
Chellappagounder Thangavel,Jeffry L Dean, Adam Ertel,Karen E Knudsen, C Marcelo Aldaz,Agnieszka K Witkiewicz,Robert Clarke & Erik S Knudsen
333–345
Hyperplasia–adenoma sequence in pituitarytumorigenesis related to aryl hydrocarbonreceptor interacting protein gene mutation
Chiara Villa, Maria Stefania Lagonigro,Flavia Magri, Maria Koziak,Marie-Lise Jaffrain-Rea, Raja Brauner,Jerome Bouligand, Marie Pierre Junier,Federico Di Rocco, Christian Sainte-Rose,Albert Beckers, Francois Xavier Roux,Adrian F Daly & Luca Chiovato
347–356
www.endocrinology-journals.org
Changes in insulin resistance indicators,IGFs, and adipokines in a year-long trial ofaerobic exercise in postmenopausal women
Christine M Friedenreich,Heather K Neilson, Christy G Woolcott,Anne McTiernan, Qinggang Wang,Rachel Ballard-Barbash,Charlotte A Jones, Frank Z Stanczyk,Rollin F Brant, Yutaka Yasui, Melinda LIrwin, Kristin L Campbell,Margaret L McNeely, Kristina H Karvinen& Kerry S Courneya
357–369
Modification of menopausal hormonetherapy-associated colorectal cancer risk bypolymorphisms in sex steroid signaling,metabolism and transport related genes
Anja Rudolph, Juan Sainz,Rebecca Hein, Michael Hoffmeister,Bernd Frank, Asta Forsti,Hermann Brenner, Kari Hemminki &Jenny Chang-Claude
371–384
Number 4 $ August 2011
COMMENTARY: Killing the secondmessenger: targeting loss of cell cyclecontrol in endocrine-resistant breast cancer
Carol A Lange & Douglas Yee C19–C24
COMMENTARY: Leptin and cancer: fromcancer stem cells to metastasis
Jiyoung Park & Philipp E Scherer C25–C29
REVIEW: The RNA-binding proteinSam68 is a multifunctional player in humancancer
Pamela Bielli, Roberta Busa, Maria PaolaParonetto & Claudio Sette
R91–R102
REVIEW: Pathways of chemotherapyresistance in castration-resistant prostatecancer
Kate L Mahon, Susan M Henshall,Robert L Sutherland & Lisa G Horvath
R103–R123
REVIEW: Insulin receptor and cancer Antonino Belfiore & RobertaMalaguarnera
R125–R147
The TORC1/TORC2 inhibitor, Palomid529, reduces tumor growth and sensitizes todocetaxel and cisplatin in aggressive andhormone-refractory prostate cancer cells
Giovanni Luca Gravina, FrancescoMarampon, Foteini Petini,Leda Biordi, David Sherris, EmmanueleA Jannini, Vincenzo Tombolini &Claudio Festuccia
385–400
In vitro transforming potential, intracellularsignaling properties, and sensitivity to akinase inhibitor (sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu,and Arg886Trp
Hugo Prazeres, Joana P Couto, FernandoRodrigues, Joao Vinagre, Joana Torres,Vitor Trovisco, Teresa C Martins, ManuelSobrinho-Simoes & Paula Soares
401–412
www.endocrinology-journals.org
Survivin upregulation, dependent onleptin–EGFR–Notch1 axis, is essentialfor leptin-induced migration of breastcarcinoma cells
Brandi B Knight, Gabriela MOprea-Ilies, Arumugam Nagalingam,Lily Yang, Cynthia Cohen,Neeraj K Saxena & Dipali Sharma
413–428
Hashimoto’s thyroiditis is associated withpapillary thyroid carcinoma: role of TSHand of treatment with L-thyroxine
E Fiore, T Rago, F Latrofa,M A Provenzale, P Piaggi,A Delitala, M Scutari, F Basolo,G Di Coscio, L Grasso, A Pinchera &P Vitti
429–437
Targeting protein kinase C by Enzastaurinrestrains proliferation and secretion inhuman pancreatic endocrine tumors
Daniela Mole, Teresa Gagliano,Erica Gentilin, Federico Tagliati,Claudio Pasquali, Maria RosariaAmbrosio, Giancarlo Pansini,Ettore C degli Uberti &Maria Chiara Zatelli
439–450
Dihydrotestosterone upregulates theexpression of epidermal growth factorreceptor and ERBB2 in androgen receptor-positive bladder cancer cells
Yichun Zheng, Koji Izumi,Jorge L Yao & Hiroshi Miyamoto
451–464
Novel candidate colorectal cancerbiomarkers identified by methylationmicroarray-based scanning
Yuriko Mori, Alexandru V Olaru, YulanCheng, Rachana Agarwal, Jian Yang,Delgermaa Luvsanjav, Wayne Yu, FlorinM Selaru, Susan Hutfless, Mark Lazarev,John H Kwon, Steven R Brant,Michael R Marohn, David F Hutcheon,Mark D Duncan, Ajay Goel &Stephen J Meltzer
465–478
Different gene expression profiles inmetastasizing midgut carcinoid tumors
Katarina Edfeldt, Peyman Bjorklund,Goran Akerstrom, Gunnar Westin,Per Hellman & Peter Stalberg
479–489
Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese miceand abrogates tumor initiating cell survival
Qiao Zheng, Sarah M Dunlap, JinlingZhu, Erinn Downs-Kelly, Jeremy Rich,Stephen D Hursting, Nathan A Berger &Ofer Reizes
491–503
Y-box binding protein-1 promotescastration-resistant prostate cancer growthvia androgen receptor expression
Masaki Shiota, Ario Takeuchi,YooHyun Song, Akira Yokomizo,Eiji Kashiwagi, Takeshi Uchiumi,Kentaro Kuroiwa, Katsunori Tatsugami,Naohiro Fujimoto, Yoshinao Oda &Seiji Naito
505–517
www.endocrinology-journals.org
Functional characterization of the MTC-associated germline RET-K666E mutation:evidence of oncogenic potential enhancedby the G691S polymorphism
Maria Grazia Borrello, Antonella Aiello,Bernard Peissel, Maria Grazia Rizzetti,Piera Mondellini, Debora Degl’Innocenti,Veronica Catalano, Morena Gobbo, PaolaCollini, Italia Bongarzone,Marco A Pierotti, Angela Greco& Ettore Seregni
519–527
Antineoplastic effect of iodine and iodide indimethylbenz[a]anthracene-inducedmammary tumors: association betweenlactoperoxidase and estrogen-adductproduction
Ofelia Soriano, Guadalupe Delgado,Brenda Anguiano, Pavel Petrosyan,Edith D Molina-Servın,Maria E Gonsebatt & Carmen Aceves
529–539
Number 5 $ October 2011
REVIEW: Hooked on zebrafish: insightsinto development and cancer of endocrinetissues
Caitlin Bourque & Yariv Houvras R149–R164
REVIEW: Rare metastases of differentiatedthyroidcarcinoma: pictorial review
Hong-Jun Song, Yan-Li Xue,Yan-Hong Xu, Zhong-Ling Qiu& Quan-Yong Luo
R165–R174
REVIEW: Intratumoral androgenbiosynthesis in prostate cancerpathogenesis and response to therapy
Changmeng Cai & Steven P Balk R175–R182
Alternatively spliced androgen receptorvariants
Scott M Dehm & Donald J Tindall R183–R196
Src kinase activity coordinates celladhesion and spreading with activation ofmammalian target of rapamycin inpancreatic endocrine tumour cells
Alessia Di Florio, Laura Adesso, SimonaPedrotti, Gabriele Capurso, EmanuelaPilozzi, Vincenzo Corbo, Aldo Scarpa,Raffaele Geremia, Gianfranco Delle Fave& Claudio Sette
541–554
The role of FOXO3 in DNA damageresponse in thyrocytes
Antje Klagge, Carl Weidinger, KerstinKrause, Beate Jessnitzer, MonikaGutknecht & Dagmar Fuhrer
555–564
Changes in breast cancer biomarkers in theIGF1R/PI3K pathway in recurrent breastcancer after tamoxifen treatment
S C Drury, S Detre, A Leary,J Salter, J Reis-Filho, V Barbashina,C Marchio, E Lopez-Knowles,Z Ghazoui, K Habben, S Arbogast,S Johnston & M Dowsett
565–577
www.endocrinology-journals.org
Can the microRNA signature distinguishbetween thyroid tumors of uncertainmalignant potential and other well-differentiated tumors of the thyroid gland?
Sandra Lassalle, Veronique Hofman,Marius Ilie, Christelle Bonnetaud,Marie-Pierre Puissegur, Patrick Brest,Celine Loubatier, Nicolas Guevara,Olivier Bordone, Bruno Cardinaud,Kevin Lebrigand, Geraldine Rios,Joseph Santini, Brigitte Franc,Bernard Mari, Abir Al Ghuzlan,Philippe Vielh, Pascal Barbry &Paul Hofman
579–594
Hepatic arterial infusion enhancesDOTATOC radiopeptide therapy inpatients with neuroendocrine livermetastases
Clemens Kratochwil, RubenLopez-Benıtez, Walter Mier,Sabine Haufe, Berend Isermann,Hans-Ulrich Kauczor,Peter L Choyke, Uwe Haberkorn& Frederik L Giesel
595–602
In silico and in vitro analysis of raregermline allelic variants of RET oncogeneassociated with medullary thyroid cancer
B Cosci, A Vivaldi, C Romei,F Gemignani, S Landi, R Ciampi,A Tacito, E Molinaro, L Agate,V Bottici, V Cappagli, D Viola,P Piaggi, P Vitti, A Pinchera& R Elisei
603–612
Inhibition of gap junction transfer sensitizesthyroid cancer cells to anoikis
Kirk Jensen, Aneeta Patel,Joanna Klubo-Gwiezdzinska,Andrew Bauer & Vasyl Vasko
613–626
The impact of ovulation on fallopian tubeepithelial cells: evaluating three hypothesesconnecting ovulation and serous ovariancancer
Shelby M King, Tyvette S Hilliard,Lucia Y Wu, Randal C Jaffe,Asgerally T Fazleabas &Joanna E Burdette
627–642
Erratum X1
Number Supplement 1 $ October 2011
EDITORIAL: Neuroendocrine tumors:recent progress in diagnosis and treatment
Kjell Oberg E3–E6
Classification and pathology ofgastroenteropancreatic neuroendocrineneoplasms
Gunter Kloppel S1–S16
www.endocrinology-journals.org
Circulating biomarkers in gastroenteropan-creatic neuroendocrine tumours
Kjell Oberg S17–S25
Nuclear medicine techniques for theimaging and treatment of neuroendocrinetumours
Jaap J M Teunissen,Dik J Kwekkeboom, R Valkema& Eric P Krenning
S27–S51
Therapeutic management of patients withgastroenteropancreatic neuroendocrinetumours
Mohid S Khan & Martyn E Caplin S53–S74
Number 6 $ December 2011
COMMENTARY: Quantitative validationof GJC1 promoter hypermethylation inbenign and malignant colorectal tumors
Deeqa Ahmed, Ragnhild A Lothe,Edgar Rivedal & Guro E Lind
C31–C34
REVIEW: Expression and function of ErbBreceptors and ligands in the pituitary
Odelia Cooper, George Vlotides,Hidenori Fukuoka, Mark I Greene& Shlomo Melmed
R197–R211
REVIEW: Neuroblastoma therapy: what isin the pipeline?
Carla S Verissimo, Jan J Molenaar,Carlos P Fitzsimons & Erno Vreugdenhil
R213–R231
REVIEW: The role of somatostatin anddopamine D2 receptors in endocrine tumors
Federico Gatto & Leo J Hofland R233–R251
REVIEW: Genetics and clinicalcharacteristics of hereditarypheochromocytomas and paragangliomas
Jenny Welander, Peter Soderkvist& Oliver Gimm
R253–R276
The role of microRNA deregulation in thepathogenesis of adrenocortical carcinoma
Deniz M Ozata, Stefano Caramuta, DavidVelazquez-Fernandez, Pinar Akcakaya,Hong Xie, Anders Hoog, Jan Zedenius,Martin Backdahl, Catharina Larsson &Weng-Onn Lui
643–655
Knockdown of survivin (BIRC5) causesapoptosis in neuroblastoma via mitoticcatastrophe
Fieke Lamers, Ida van der Ploeg,Linda Schild, Marli E Ebus, Jan Koster,Bo R Hansen, Troels Koch,Rogier Versteeg, Huib N Caron &Jan J Molenaar
657–668
www.endocrinology-journals.org
BRAFV600E mutation, TIMP-1upregulation, and NF-kB activation:closing the loop on the papillary thyroidcancer trilogy
Alessandra Bommarito, Pierina Richiusa,Elvira Carissimi, Giuseppe Pizzolanti,Vito Rodolico, Giovanni Zito, AngelaCriscimanna, Francesco Di Blasi, MariaPitrone, Monica Zerilli, Marco C Amato,Gaetano Spinelli, Valeria Carina,Giuseppe Modica, M Adelfio Latteri,Aldo Galluzzo & Carla Giordano
669–685
Genome-wide alterations in genemethylation by the BRAF V600E mutationin papillary thyroid cancer cells
Peng Hou, Dingxie Liu &Mingzhao Xing
687–697
IGF1/insulin receptor kinase inhibition byBMS-536924 is better tolerated thanalloxan-induced hypoinsulinemia and moreeffective than metformin in the treatment ofexperimental insulin-responsive breastcancer
Carly Jade Dool, Haider Mashhedi,Mahvash Zakikhani, Stephanie David,Yunhua Zhao, Elena Birman, Joan MCarboni, Marco Gottardis, Marie-JoseBlouin & Michael Pollak
699–709
MiR-129-5p is required for histonedeacetylase inhibitor-induced cell death inthyroid cancer cells
Patrick Brest, Sandra Lassalle, VeroniqueHofman, Olivier Bordone, VirginieGavric Tanga, Christelle Bonnetaud,Chimene Moreilhon, Geraldine Rios,Jose Santini, Pascal Barbry, CatharinaSvanborg, Baharia Mograbi, BernardMari & Paul Hofman
711–719
Low residual proliferation after short-termletrozole therapy is an early predictivemarker of response in high proliferativeER-positive breast cancer
Philippe L Bedard, Sandeep K Singhal,Michail Ignatiadis, Ian Bradbury,Benjamin Haibe-Kains, ChristineDesmedt, Sherene Loi, Dean B Evans,Stefan Michiels, J Michael Dixon,William R Miller, Martine J Piccart &Christos Sotiriou
721–730
CDC23 regulates cancer cell phenotype andis overexpressed in papillary thyroid cancer
Lisa Zhang, Reza Rahbari, Mei He &Electron Kebebew
731–742
Evidence of oncogene-induced senescencein thyroid carcinogenesis
Maria Grazia Vizioli, Patricia A Possik,Eva Tarantino, Katrin Meissl,Maria Grazia Borrello, Claudia Miranda,Maria Chiara Anania, Sonia Pagliardini,Ettore Seregni, Marco A Pierotti,Silvana Pilotti, Daniel S Peeper& Angela Greco
743–757
Protein kinase Cd inactivation inhibitscellular proliferation and decreases survivalin human neuroendocrine tumors
Zhihong Chen, Lora W Forman,Kenneth A Miller, Brandon English,Asami Takashima, Regine A Bohacek,Robert M Williams & Douglas V Faller
759–771
www.endocrinology-journals.org
Total oxidant/antioxidant status in sera ofpatients with thyroid cancers
Dong Wang, Jia-Fu Feng,Ping Zeng, Yun-Hong Yang,Jun Luo & Yu-Wei Yang
773–782
Apoptosis gene signature of Survivin andits splice variant expression in breastcarcinoma
Frederique Vegran, Romain Boidot,Franck Bonnetain, Muriel Cadouot,Sandy Chevrier & Sarab Lizard-Nacol
783–792
LETTER TO THE EDITOR: Diagnosticaccuracy and clinical significance of thefine needle aspiration Ki-67 labelling indexin pancreatic endocrine tumours
Michail Kaklamanos, IoannisKaroumpalis, Charitini Salla, DimitriosThomas, George Kanakis, KrystalleniaAlexandraki, Stavros Sougioultzis,Evanthia Diakatou, George Kontogeorgos& Gregory Kaltsas
L1–L3
ERRATUM: Can the microRNA signaturedistinguish between thyroid tumors ofuncertain malignant potential and otherwell-differentiated tumors of the thyroidgland?
Sandra Lassalle, Veronique Hofman,Marius Ilie, Christelle Bonnetaud,Marie-Pierre Puissegur, Patrick Brest,Celine Loubatier, Nicolas Guevara,Olivier Bordone, Bruno Cardinaud,Kevin Lebrigand, Geraldine Rios,Joseph Santini, Brigitte Franc,Bernard Mari, Abir Al Ghuzlan,Philippe Vielh, Pascal Barbry &Paul Hofman
X3
www.endocrinology-journals.org
Endocrine -Related Cancer
• Cellular and Molecular Biology of Hormones and Growth Factors Pathogenetic in Cancer
• Hormone-Dependent Neoplasms• Hormonal Carcinogenesis
DECEMBER 2011Volume 18Issue 6ISSN 1351-0088 (print)ISSN 1479-6821 (online)
Endocrine-Related CancerVolum
e 18Num
ber 6Decem
ber 2011Pages R000–R000, 000–000, X1
1351-0088(201112)18:6;1-7
ERC 18_6_cover.qxp 10/20/11 6:18 PM Page 1