CURRICULUM VITAE

Volker Vallon, M.D.

Office Address: University of California San Diego

Department of Medicine and

Department of Pharmacology

Division of Nephrology & Hypertension

& VA San Diego Health Care System

3350 La Jolla Village Drive (9151)

San Diego, CA 92161

Phone: 858-552-8585 X5945

E-mail: vvallon@ucsd.edu

Date of Birth: November 11, 1964

Place of Birth: Stockach, Baden, Germany

Marital Status: married, 2 daughters

Education, Training, and Positions:

7/2010 – today Professor of Medicine and Pharmacology

Divison of Nephrology & Hypertension, Department of Medicine, and

Department of Pharmacology, University of California San Diego

10/2003 – today Principal Investigator, VA San Diego Health Care System

10/2003 – 6/2010: Associate Professor of Medicine and Pharmacology

Divison of Nephrology & Hypertension, Department of Medicine, and

Department of Pharmacology, University of California San Diego

11/1998 -9/2003: Lecturer (“Privatdozent”)

Dept. of Pharmacology, University of Tübingen

5/1999 - 11/1999: Visiting Scientist / Courtesy Associate

National Institute of Diabetes and Digestive and Kidney Disease (NIDDK),

National Institutes of Health (NIH), Bethesda, MD

(J. Schnermann, M.D.; J. Briggs, M.D.)

11/1998: Habilitation in Pharmacology and Toxicology, University of Tübingen

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5/1998: Board Certification as a Physician for Pharmacology and

Toxicology, Baden-Württemberg, Germany

7/1995 - 11/1998: Research Associate

Dept. of Pharmacology, University of Tübingen (H. Osswald, M.D.)

7/1993 - 6/1995: Postdoctoral Research Fellow (German Research Foundation) Dept.

of Medicine, Div. of Nephrology and Hypertension, University of California

San Diego CA, (R.C. Blantz, M.D.)

1/1992 - 6/1993: Postdoctoral Fellow

Experimental and Clinical Pharmacology, Dept. of Pharmacology,

University of Tübingen (H. Osswald, M.D.) and Dept. of Internal Medicine

(T. Risler, M.D.)

11/1991: Licenced as a physician

1990 - 1991: Praktisches Jahr, Internship, University of Tübingen

1989 – 5/1992: Doctoral thesis, Dept. of Medicine, Institute of Occupational Medicine,

University of Tübingen (F.W. Schmahl, M.D.)

1985 - 1991: Medical School, University of Tübingen, Germany

1984 - 1985: Military service, Ulm, Germany

1975 - 1984: Johannes Kepler Gymnasium, Weil der Stadt, Germany

San Diego, Juli 2010 Volker Vallon, M.D.

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MEMBER OF EDITORIAL BOARD: - Nephron Physiology (since 2003) - Kidney and Blood Pressure Research (since 2003) - Pfluger=s Archives - European Journal of Physiology (2004-2007) - American Journal of Physiology – Renal Physiology (since 2007) - The Open Urology and Nephrology Journal (since 2008) GRANT REVIEW COMMITTEES: - The Wellcome Trust, London (2004-2006,2008) - Kidney Research UK, London (2007) - Veterans Affairs (VA) Merit Review Board - Renal Section, Washington D.C. (2007-2010) - American Heart Association, Cardiorenal Study Section, Dallas (since 2007) - Israel Science Foundation, Jerusalem (2008) - NIH, Pathobiology of Kidney Diseases (PBKD) Study Section, Washington D.C. (2010) AWARDS AND HONORS: - Travel Fellowship, XII Int. Congress of Int. Soc. of Nephrol., Jerusalem, Israel (1993) - Fellowship, German Research Association (DFG), UC California San Diego (1993-1995) - Trainee Investigator Award, American Society for Clinical Investigation (1994) - Consultant, UC San Diego, Dept. Medicine, Div. Nephrology and Hypertension (1998) - Best Poster Award, German Society of Pharmacology and Toxicology, Mainz (1999, 2003) - Courtesy Associate, National Institute of Diabetes and Digestive and Kidney Disease

(NIDDK), National Institutes of Health (NIH), Bethesda, MD (1999) - Best Poster Award, German Soc. Nephrol., Münster (2001), Basel (2004), Tübingen (2008) - Poster Award, World Congress of Nephrology, Berlin (2003) - New Investigator Award in Regulatory and Integrative Physiology; Water and Electrolyte

Homeostasis Section, American Physiological Society, Washington (2004) - Young Investigator Award for Excellence in Renal Physiology; Renal Section, American

Physiological Society, Washington (2007)

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PROFESSIONAL COMMITTEE SERVICES: - Chair oral scientific session, Annual Meeting, German Society of Nephrology (2001) - Chair poster session, Annual Meeting, German Physiological Society (2002) - Abstract reviewer, Annual Meeting, American Society of Nephrology (2002) - Abstract reviewer, Annual Meeting, German Society of Nephrology (2002) - Chair oral scientific session, Annual Meeting of the ASN (2002) - Chair oral session, Annual Meeting, German Society of Pharmacology & Toxicology (2003) - Abstract reviewer, Annual Meeting, American Heart Association (2003) - Chair oral scientific session, Experimental Biology Meeting FASEB (2004) - Abstract reviewer, Annual Meeting, American Heart Association (2004) - Chair oral session, Annual Meeting, German Society of Pharmacology & Toxicology (2005) - Abstract reviewer, Annual Meeting, American Heart Association (2005) - Abstract reviewer, Annual Meeting, American Heart Association (2006) - Chair oral & poster session, Int. Society of Hypertension, Symposium, Tokyo (2006) - Chair oral session, Workshop, Mathematical Biosciences Institute, Ohio (2007) - Member, Inst. Animal Care and Use Committee, VA Medical Center, San Diego (2007- ) - Abstract reviewer, ISN World Congress in Nephrology, Rio de Janeiro (2007) - Chair and organizer, oral session, Experimental Biology Meeting FASEB (2007) - Abstract reviewer, Annual Meeting, American Society of Nephrology (2008) - Faculty, Annual Meeting, American Society of Nephrology (2008) - Chair 2 oral scientific sessions, Annual Meeting, American Society of Nephrology (2008) - Abstract reviewer, ISN World Congress in Nephrology, Milan (2009) - Vice chair, Inst. Animal Care and Use Committee, VA Medical Center, San Diego (2009- ) - Renal Section Award Committee; American Physiological Society, Bethesda (2009- ) - Faculty, Annual Meeting, American Society of Nephrology (2010) - Chair oral scientific session, Annual Meeting, German Society of Nephrology (2010) - Renal Section Steering Cmte, Awards Co-Chair, American Physiological Society (2010- )

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GRANT SUPPORT (completed): Deutsche Forschungsgemeinschaft DFG Va 118/2-1 - Principal Investigator Time: 7/1993-6/1995 Topic: Physiology and pathophysiology of renal hemodynamics and tubular

reabsorption (at University of California San Diego) Deutsche Forschungsgemeinschaft DFG Va 118/3-1 - Principal Investigator Time: 12/1995-11/1997 Topic: Glomerular hyperfiltration and renal growth in experimental diabetes mellitus:

role of tubular reabsorption Deutsche Forschungsgemeinschaft DFG Os 42/9-1 Time: 12/1996-11/1998 Topic: Experiments on ATP-sensitive potassium channels in the tubular system of the

kidney University of Tübingen, fortüne (Nr. 427) - Principal Investigator Time: 1/1998-1/1999 Topic: Isoforms of protein kinase C in the kidney of diabetic rats Federal Ministry of Education, Science, Research and Technology BMBF 01 KS 9602 – Co-PI Time: 7/1996-6/1999 Topic: Pathophysiology of tubular transport mechanisms in arterial hypertension and

diabetic nephropathy Deutsche Forschungsgemeinschaft DFG Va 118/4-1 - Principal Investigator Time: 5/1999-11/1999 Topic: Micropuncture technique and molecular biology in mice (at the National Institute

of Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes of Health (NIH), Bethesda, MD)

Federal Ministry of Education, Science, Research and Technology BMBF 01 EC 9405 – Co-PI Time: 4/1996-3/2000 Topic: Pathophysiology of glomerular hyperfitration in diabetes mellitus

Deutsche Forschungsgemeinschaft DFG Va 118/3-2 - Principal Investigator Time: 12/1998-5/2001 Topic: Role of beta Isoforms of protein kinase C in diabetic nephropathy Hoechst Marion Roussel; Disease Group Cardiovascular; Germany - Principal Investigator Time: 4/1999-3/2000 Topic Effect of selective inhibitors of NHE1, NHE2 and NHE3 on tubular reabsorption

and tubuloglomerular feedback Federal Ministry of Education, Science, Research and Technology BMBF 01 KS 9602 – Co-PI Time: 7/1999-6/2002 Topic: Control of renin secretion and renal hemodynamics in diabetes mellitus Deutsche Forschungsgemeinschaft DFG Va 118/3-2 - Principal Investigator Time: 4/2000 Topic: Traveling support

- National Institutes of Health, Bethesda - Yale University, New Haven - Experimental Biology Meeting, San Diego

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GRANT SUPPORT (completed): (continued) Dr. Karl-Kuhn-Stiftung - Principal Investigator Time: 8/1999-7/2000 Topic: Micropuncture studies in transgenic mice Schwarz Pharma AG; Monheim, Germany - Principal Investigator Time: 3/2000-12/2000 Topic New pharmacological approaches in nephroprotection Aventis Pharma; Disease Group Cardiovascular; Germany - Principal Investigator Time: 6/2000-12/2000 Topic New pharmacological approaches in hypertension Dr. Karl-Kuhn-Stiftung - Principal Investigator Time: 10/2000-9/2001 Topic: Micropuncture studies in IsK and TWIK-1 knockout mice Aventis Pharma; Disease Group Cardiovascular; Germany - Principal Investigator Time: 2/2001-8/2001 Topic New pharmacological approaches in hypertension Deutsche Forschungsgemeinschaft DFG Va 118/7-1 - Principal Investigator Time: 10/2000-5/2003 Topic: Role of potassium channels for tubular transport in the kidney: studies in IsK

and TWIK-1 knockout mice University of Tübingen, fortüne (Nr. 427) - Principal Investigator Time: 8/2001-7/2003 Topic: Protein kinase C isoforms alpha , beta 1 and beta 2 in the kidney of the mouse:

localization and expression in experimental diabetes mellitus Federal Ministry of Education, Science, Research and Technology BMBF - Principal Investigator Time: 7/2002-6/2005 Topic: Serum- and glucocorticoid-regulated kinase 1 (SGK1) in the control of renal

electrolyte excretion and pathogenesis of arterial hypertension Deutsche Forschungsgemeinschaft DFG Ri 1535/3-1/2 - Mentor Time: 5/2004-4/2007 Topic: Fellowship for Dr Timo Rieg to join my lab at UC San Diego NIH-R21DK070667 - Co-Investigator (PI: Joseph Satriano, UCSD) Time: 04/2006-03/2008 Topic: Functional Consequences of Early Diabetic Kidney Growth NIH-R01 GM66232 – Co-investigator (PI: Paul Insel, UCSD) Time: 10/2004-9/2008 Topic: Adrenergic and Purinergic Regulation of Target Cells Takeda Pharma – Principal Investigator Time: 07/06-06/08 Topic: Renal Effects of Pioglitazone AHA-Grant in Aid 655232Y – Principal Investigator Time: 07/06-06/08 Topic: Mechanism of Thiazolidinedione-induced Fluid Retention in the Kidney

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GRANT SUPPORT (completed) (continued) National Kidney Foundation – Mentor Time: 07/08-06/09 Topic: Fellowship for Dr Timo Rieg NIH-R01DK56248 – Co-investigator (PI: Scott Thomson, UCSD) Time: 04/2005-3/2010 Topic: Glomerular and Tubular Function in the Diabetic Kidney Bristol-Myers Squibb – Principal Investigator Time: 05/08-04/10 Topic: Sodium-Glucose Transport and Physiology of the Diabetic Kidney

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CURRENT GRANT SUPPORT NIH-R01DK28602 - Co-Investigator (PI: Roland Blantz, UCSD) Time: 02/07-01/12 Topic: Autoregulation of Glomerular Filtration Rate NIH-P30DK079337 – Co-investigator (O’Brien Core Center) Time: 09/08-7/13 Topic: University of Alabama-UC San Diego O’Brien Core Center for Acute Kidney Injury Research NIH-R01DK079784 – Co-Investigator (PI: Sanjay Nigam, UCSD) Time: 3/08-02/12 Topic: Mechanism of fetal and neonatal handling of HIV drugs NIH-R01GM66232-05 – Co-investigator (PI: Paul Insel, UCSD) Time: 08/2009-07/2011 Topic: Adrenergic and Purinergic Regulation of Target Cells Takeda Pharma – Principal Investigator Time: 03/10-03/12 Topic: Alogliptin Effects on the Kidney NIH-R01HL094728 – Principal Investigator (Co-PI: Satish Eraly, UCSD) Time: 06/10-04/15 Topic: Blood Pressure Regulation by OAT3 AHA-10GRNT3440038 – Principal Investigator Time: 07/10-06/12 Topic: Role of epithelial sodium channel in thiazolidinedione-induced fluid retention Bristol-Myers Squibb – Principal Investigator (Co-PI: Kumar Sharma, UCSD) Time: 07/10-06/12 Topic: Glucose toxicity and SGLT in Diabetic Kidney Disease

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PUBLICATIONS Doctoral Thesis: An oral fat tolerance test in 40- 50 year old healthy male volunteers to determine postprandial serum lipid and lipoprotein levels and to test the reproducibility of postprandial serum triglyceride profiles. University of Tübingen, 1992. - magna cum laude - Original publikations: 1. Vallon V, Osswald H. Dipyridamole prevents diabetes-induced alterations of kidney function

in rats. Naunyn-Schmiedeberg's Arch Pharmacol 349:217-222, 1994. 2. Vallon V, Wead LM, Blantz RC. Renal hemodynamics and plasma and kidney angiotensin

II in established diabetes mellitus in rats: effect of sodium and salt restriction. J Am Soc Nephrol 5:1761-1767, 1995. 3. Vallon V, Blantz RC, Thomson SC. Homeostatic efficiency of tubuloglomerular feedback is

reduced in established diabetes mellitus in rats. Am J Physiol 269: F876-F883, 1995. 4. Thomson SC, Vallon V. Alpha-2-adrenoceptors determine the response to nitric oxide

inhibition in the rat glomerulus and proximal tubule. J Am Soc Nephrol 6:1482-1490, 1995. 5. Vallon V, Thomson SC. Inhibition of local nitric oxide synthase increases homeostatic

efficiency of tubuloglomerular feedback. Am J Physiol 269: F892-F899, 1995. 6. Vallon V, Thomson S, Peterson OW, Gabbai FB, Blantz RC. Interactive control of renal

function by 2-adrenergic system and nitric oxide: role of angiotensin II. J Cardiovasc Pharmacol 26:916-922, 1995. 7. Thomson SC, Blantz RC, Vallon V. Increased tubular flow induces resetting of

tubuloglomerular feedback. Am J Physiol 270: F461-F468, 1996. 8. Lortie MJ, Novotny WF, Peterson OW, Vallon V, Malvey K, Mendonca M, Satriano J, Insel

P, Thomson SC, Blantz RC. Agmatine, a bioactive metabolite of arginine: production, degradation, and functional effects in the kidney of the rat.

J Clin Invest 97:413-420, 1996. 9. Thomson S, Vallon V, Blantz RC. Asymmetry of tubuloglomerular feedback effector

mechanism with respect to ambient tubular flow. Am J Physiol 271: F1123-F1130, 1996. 10. Vallon V, Kirschenmann D, Wead LM, Lortie MJ, Satriano J, Blantz RC, Thomson SC.

Effect of chronic salt loading on kidney function in early and established diabetes mellitus in rats.

J Lab Clin Med 130:76-82, 1997. 11. Vallon V, Richter K, Heyne N, Osswald H. Effect of intratubular application of angiotensin 1-

7 on nephron function. Kidney Blood Press Res 20:233-239, 1997.

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Original publications: (continued) 12. Thomson SC, Vallon V, Blantz RC. Reduced proximal reabsorption resets tubuloglomerular

feedback in euvolemic rats. Am J Physiol 273:R1414-R1420, 1997. 13. Vallon V, Osswald H, Blantz RC, Thomson SC. Potential role of luminal potassium in

tubuloglomerular feedback. J Am Soc Nephrol 8:1831-1837, 1997. 14. Mühlbauer B, Luippold G, Vallon V, Russ H, Osswald H, Schömig E. Disprocynium24

induces a dopamine-independent eukaliuric natriuresis in the anesthetized rat. Naunyn-Schmiedeberg's Arch Pharmacol 356:846-849, 1997. 15. Vallon V, Heyne N, Richter K, Khosla MC, Fechter K. [7-D-Ala]-angiotensin 1-7 blocks renal

actions of angiotensin 1-7 in the anesthetized rat. J Cardiovasc Pharmacol 32:164-167, 1998. 16. Vallon V, Kirschenmann D, Brenner I, Albinus M, Osswald H. Potassium diet as a

determinant for the renal response to systemic potassium channel modulation in anesthetized rats.

Naunyn-Schmiedeberg's Arch Pharmacol 358:245-252, 1998. 17. Vallon V, Richter K, Osswald H, Schömig E, Mühlbauer B. Eukaliuric natriuresis and

diuresis in response to disprocynium24: studies on the tubular site of action. Naunyn-Schmiedeberg's Arch Pharmacol 358:238-244, 1998. 18. Vallon V, Albinus M, Blach D. Effect of KATP channel blocker U37883A on renal function in

experimental diabetes mellitus. J Pharmacol Exp Ther 286:1215-1221, 1998. 19. Huang DY, Osswald H, Vallon V. Intratubular application of sodium azide inhibits loop of

Henle reabsorption and tubuloglomerular feedback response in anesthetized rats. Naunyn-Schmiedeberg's Arch Pharmacol 358:367-373, 1998. 20. Pfaff IL, Wagner H-J, Vallon V. Immunolocalization of protein kinase C isoenzymes , I and

II in rat kidney. J Am Soc Nephrol 10, 1861-1873, 1999. 21. Huang DY, Osswald H, Vallon V. Eukaliuric natriuresis and diuresis in response to the KATP

channel blocker U37883A: micropuncture studies on the tubular site of action. Br J Pharmacol 127: 1811-1818, 1999. 22. Vallon V, Richter K, Blantz RC, Thomson S, Osswald H. Glomerular hyperfiltration in

experimental diabetes mellitus: potential role of tubular reabsorption. J Am Soc Nephrol 10: 2569-2576, 1999. 23. Vallon V, Schwark J-R, Richter K, Hropot M. Role of Na+/H+ exchanger NHE3 in nephron

function: micropuncture studies with S3226, an inhibitor of NHE3. Am J Physiol: Renal Physiol 278: F375-F379, 2000. 24. Luippold G, Schneider S, Vallon V, Osswald H, Mühlbauer B. Postglomerular

vasoconstriction induced by dopamine D3 receptor activation in anesthetized rats. Am J Physiol: Renal Physiol 278:F570-F575, 2000.

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Original publications: (continued) 25. Vallon V, Verkman AS, Schnermann J. Luminal hypotonicity in proximal tubules of

aquaporin1 knockout mice. Am J Physiol: Renal Physiol 278:F1030-F1033, 2000. 26. Huang DY, Osswald H, Vallon V. Sodium reabsorption in thick ascending limb of Henle’s

loop: effect of potassium channel blockade in vivo. Br J Pharmacol, 130:1255-1262, 2000. 27. Huang DY, Pfaff I, Serradeil-Le Gal C, Vallon V. Acute renal response to the non-peptide

vasopressin V2-receptor antagonist SR 121463B in anesthetized rats. Naunyn-Schmiedeberg's Arch Pharmacol, 362:201-207, 2000. 28. Thomson S, Bao D, Deng A, Vallon V. Adenosine formed by 5'-nucleotidase mediates

tubuloglomerular feedback. J Clin Invest, 106:289-298, 2000. 29. Thomson SC, Deng A, Bao D, Satriano J, Blantz RC, Vallon V. Ornithine decarboxylase,

kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.

J Clin Invest, 107:217-224, 2001. 30. Vallon V, Traynor T, Barajas L, Huang YG, Briggs JP, Schnermann J. Feedback control of

glomerular vascular tone in nNOS knockout mice. J Am Soc Nephrol, 12:1599-1606, 2001. 31. Vallon V, Grahammer F, Richter K, Bleich M, Lang F, Barhanin J, Völkl H, Warth R. Role of

KCNE1-dependent K+ fluxes in mouse proximal tubule. J Am Soc Nephrol, 12:2003-2011, 2001. 32. Huang DY, Richter K, Breidenbach A, Vallon V. Human C-peptide acutely lowers

glomerular hyperfiltration and proteinuria in diabetic rats: a dose-response study. Naunyn-Schmiedeberg's Arch Pharmacol, 365: 67-73, 2002. 33. Vallon V, Huang DY, Deng A, Richter K, Blantz RC, Thomson SC. Salt-sensitivity of

proximal reabsorption alters macula densa salt and explains the paradoxical effect of dietary salt on glomerular filtration rate in diabetes mellitus.

J Am Soc Nephrol, 13:1865-1871, 2002. 34. Pfaff IL, Vallon V. Protein kinase C beta isoenzymes in experimental diabetes mellitus and

their relation to nephroprotective actions of the ACE inhibitor lisinopril. Kidney Blood Press Res, 25:329-40, 2002. 35. Wulff P, Vallon V, Huang DY, Völkl H, Yu F, Richter K, Jansen M, Schlünz M, Klingel K,

Loffing J, Kauselmann G, Bösl MR, Lang F, Kuhl D. Impaired renal Na+ retention in the sgk1-knockout mouse.

J Clin Invest, 110:1263-1268, 2002. 36. Embark HM, Böhmer C, Vallon V, Luft F, Lang F. Regulation of KCNE1-dependent K+

current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. Eur J Physiol, 445:601-606, 2003. 37. Lang UE, Lang F, Richter K, Vallon V, Lipp HP, Schnermann J, Wolfer DP. Emotional

instability but intact spatial cognition in adenosine receptor 1 knock out mice. Behav Brain Res, 145:179-88, 2003.

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Original publications: (continued) 38. Birk C, Richter K, Huang DY, Piesch C, Luippold G, Vallon V. The salt paradox of the early

diabetic kidney is independent of renal innervation. Kidney Blood Press Res, 26:344-350, 2003. 39. Lang PA, Warskulat U, Heller-Stilb B, Huang DY, Grenz A, Myssina S, Duszenko M, Lang

F, Haeussinger D, Vallon V, Wieder T. Blunted apoptosis of erythrocytes from taurine transporter deficient mice.

Cell Physiol Biochem, 13:337-345, 2003. 40. Hoenderop JGJ, van Leeuwen JPTM, van der Eerden BCJ, Kersten FFJ, van der Kemp

AWCM, Merillat AM, Waarsing JH, Rossier BC, Vallon V, Hummler E, Bindels RJM. Renal Ca2+ wasting, hyperabsorption and reduced bone thickness in mice lacking TRPV5.

J Clin Invest, 112:1906-1914, 2003. 41. Vallon V, Richter K, Huang DY, Rieg T, Schnermann J. Functional consequences at the

single-nephron level of the lack of adenosine A1 receptors and tubuloglomerular feedback in mice.

Eur J Physiol, 448:214-21, 2004. 42. Huang DY, Wulff P, Voelkl H, Loffing J, Richter K, Kuhl D, Lang F, Vallon V. Impaired

regulation of renal K+ elimination in the sgk1-knockout mouse. J Am Soc Nephrol, 15:885-891, 2004. 43. Redling S, Pfaff IL, Leitges M, Vallon V. Immunolocalization of protein kinase C

isoenzymes alpha, beta I, beta II, delta and epsilon in mouse kidney. Am J Physiol: Renal Physiol, 287:F289-F298, 2004. 44. Yao L, Huang DY, Pfaff IL, Nie X, Leitges M, Vallon V. Evidence for a role of protein kinase

C alpha in urine concentration. Am J Physiol: Renal Physiol, 287:F299-F304, 2004. 45. Loffing J, Vallon V, Loffing-Cueni D, Aregger F, Richter K, Pietri L, Bloch-Faure M,

Hoenderop JGJ, Shull GE, Meneton P, Kaissling B. Altered renal distal tubule structure and renal Na+ and Ca2+ handling in a mouse model for Gitelman’s syndrome.

J Am Soc Nephrol, 15:2276-2288, 2004. 46. Rieg T, Richter K, Osswald H, Vallon V. Kidney function in mice: thiobutabarbital versus

alpha-chloralose anesthesia. Naunyn-Schmiedeberg's Arch Pharmacol, 370: 320-323, 2004. 47. Rieg T, Steigele H, Schnermann J, Richter K, Osswald H, Vallon V. Requirement of intact

adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine.

J Pharmacol Exp Ther, 313: 403-409, 2005. 48. Vallon V, Huang DY, Grahammer F, Wyatt AW, Osswald H, Wulff P, Kuhl D, Lang F. SGK1 as

a determinant of kidney function and salt intake in response to mineralocorticoid excess. Am J Physiol: Regul Integr Comp Physiol, 289:R395-R401, 2005. 49. Nijenhuis T, Vallon V, van der Kemp AWCM, Loffing J, Hoenderop JGJ, Bindels RJM.

Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.

J Clin Invest, 115:1651-1658, 2005.

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Original publications: (continued) 50. Nie X, Arrighi I, Kaissling B, Pfaff I, Mann J, Barhanin J, Vallon V. Expression and insights on

function of potassium channel TWIK-1 in mouse kidney. Europ J Physiol, 451:479-88, 2005. 51. Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q,

Pfeifer K, Lang F. KCNQ1 dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci U S A, 102:17864-17869, 2005. 52. Huang DY, Boini K, Lang P, Grahammer F, Duszenko M, Heller-Stilb B, Warskulat U,

Häussinger D, Lang F, Vallon V. Impaired ability to increase water excretion in mice lacking the taurine transporter gene TAUT Europ J Physiol, 451: 668-677, 2006.

53. Wyatt AW, Hussain A, Amann K, Klingel K, Kandolf R, Artunc F, Grahammer F, Huang DY,

Vallon V, Kuhl D, Lang F. DOCA-induced phosphorylation of glycogen synthase kinase 3 beta. Cell Physiol Biochem. 17:137-44, 2006.

54. Sandulache D, Grahammer F, Artunc F, Henke G, Hussain A, Nasir O, Mack A, Friedrich B,

Vallon V, Wulff P, Kuhl D, Palmada M, Lang F. Renal Ca2+ handling in sgk1-knockout mice. Europ J Physiol, 452:444-52, 2006. 55. Vallon V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F,

BelAiba RS, Görlach A, Wulff P, Daut J, Dalton ND, Ross J Jr, Osswald H, Kandolf R, Kuhl D, Lang F. SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment.

J Mol Med, 84:396-404, 2006. 56. Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, Wulff P, Kuhl D, Vallon V,

Lang V. Blunted hypertensive effect of combined fructose and high salt diet in gene targeted mice lacking functional serum and glucocorticoid inducible kinase sgk1.

Am J Physiol: Regul Integr Comp Physiol, 290: R935-R944, 2006. 57. Yao L-J, Leitges M, Vallon V. Mice lacking protein kinase C beta present modest increases in

systolic blood pressure and NH4Cl-induced metabolic acidosis. Kidney Blood Press Res, 29:36-42, 2006. 58. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong

DM, Long JM, Barshop BA, Kaler G, Nigam SK. Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knockout mice.

J Biol Chem, 281: 5072-5083, 2006. 59. Thomson SC, Deng A, Wead L, Richter K, Blantz RC, Vallon V. An unexpected role for

angiotensin II in the link between dietary salt and proximal reabsorption. J Clin Invest, 116:1110-6, 2006. 60. Huang DY, Vallon V, Zimmermann H, Koszalka P, Schrader J, Osswald H. Ecto-5’-

nucleotidase (cd73)-dependent and -independent generation of adenosine participates in the mediation of tubuloglomerular feedback in vivo.

Am J Physiol Renal Physiol, 291:F282-F288, 2006.

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Original publications: (continued) 61. Boini KM, Hennige AM, Huang DY, Friedrich B, Palmada M, Boehmer C, Grahammer F, Artunc

F, Ullrich S, Avram D, Osswald H, Wulff P, Kuhl D, Vallon V, Häring HU, Lang F. The serum and glucocorticoid inducible kinase SGK1 mediates salt sensitivity of glucose tolerance.

Diabetes, 55:2059-2066, 2006. 62. Artunc F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, Risler T, Vallon V, Wulff P,

Kuhl D, Lang F. Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1.

J Mol Medicine, 84:737-46, 2006. 63. Huang DY, Boini KM, Osswald H, Friedrich B, Artunc F, Ullrich S, Jeyaganesh R, Palmada M,

Wulff P, Kuhl D, Vallon V and Lang F. Resistance of mice lacking the serum and glucocorticoid inducible kinase sgk1 against salt-sensitive hypertension induced by high fat diet.

Am J Physiol Renal Physiol, 291:F1264-F1273, 2006. 64. Rieg T, Schnermann J, Vallon V. Adenosine A1 receptors determine effects of caffeine on total

fluid intake but not caffeine appetite. Eur J Pharmacol, 555:174-177, 2007. 65. Zhang W, Xia, X, Reisenauer MR, Rieg T, Lang F, Kuhl D, Vallon V, Kone B. Aldosterone-

induced SGK1 phosphorylates AF9 and relieves Dot1a-AF9-mediated transcriptional repression of ENaC.

J Clin Invest, 117:773-783, 2007. 66. Rieg T, Vallon V, Sausbier M, Sausbier U, Kaissling B, Ruth P, Osswald H. A role of BK

channel in K+ homeostasis and flow-induced renal K+ excretion. Kidney Int, 72:566-573, 2007. 67. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. Mice lacking P2Y2

receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J, 21:3717-26, 2007. 68. Miracle CM, Rieg T, Blantz RC, Vallon V, Thomson SC. Combined effects of carbonic

anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney.

Kidney Blood Press Res, 30:388-399, 2007. 69. Grenz A, Zhang H, Weingart J, von Wietersheim S, Eckle T, Schnermann JB, Kohle C, Kloor

D, Gleiter CH, Vallon V, Eltzschig HK, Osswald H. Lack of effect of extracellular adenosine generation and signalling on renal erythropoietin secretion during hypoxia.

Am J Physiol Renal Physiol, 293:F1501-F1511, 2007. 70. Laske-Ernst J, Stehle A, Vallon V, Quast U, Russ U. Effect of adenosine on membrane

potential and Ca2+ in juxtaglomerular cells: Comparison with angiotensin II. Kidney Blood Press Res, 31:94-103, 2008. 71. Rieg T, Pothula K, Schroth J, Satriano J, Osswald H, Schnermann J, Insel PA, Bundey RA,

Vallon V. Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors.

Am J Physiol Renal Physiol, 294:F638-F644, 2008.

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Original publications: (continued) 72. Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK. Overlapping in vitro and in vivo

specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.

Am J Physiol Renal Physiol, 294: F867-F873, 2008. 73. Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, Nigam SK.

Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiological Genomics, 33:180-192, 2008. 74. Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR,

Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, and Nigam SK. Organic anion transporter 3 contributes to the regulation of blood pressure.

J Am Soc Nephrol, 19:1732-1740, 2008. 75. Miracle CM, Rieg T, Mansoury HA, Vallon V, Thomson SC. Ornithine decarboxylase

inhibitor eliminates hyper-responsiveness of the early diabetic proximal tubule to dietary salt.

Am J Physiol Renal Physiol, 295:F995-F1002, 2008. 76. Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JD. Paracrine

regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone.

J Biol Chem, 283:36599-607, 2008. 77. Vallon V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B,

Cunard R, and Stockand J. Thiazolidinedione-induced fluid retention is independent of collecting duct ENaC activity.

J Am Soc Nephrol, 20:721-729, 2009. 78. Vallon V, Schroth J, Satriano J, Blantz RC, Thomson S, Rieg T. Adenosine A1 receptors

determine glomerular hyperfiltration and the salt paradox in early diabetes mellitus. Nephron Physiol, 111:30-38, 2009. 79. Ackermann T, Boini K, Volkl H, Bhandaru M, Bareiss P, Just L, Vallon V, Amann K, Kuhl D,

Feng Y, Hammes HP, Lang F. SGK1-sensitive renal tubular glucose reabsorption in diabetes.

Am J Physiol Renal Physiol, 296:F859-F866, 2009. 80. Boini KM, Graf D, Hennige AM, Koka S, Kempe DS, Wang K, Ackermann TF, Föller M,

Vallon V, Pfeifer K, Schleicher E, Ullrich S, Häring HU, Häussinger D, Lang F. Enhanced insulin sensitivity of gene targeted mice lacking functional KCNQ1. Am J Physiol: Regul Integr Comp Physiol, 296:R1695-R1701, 2009.

81. Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush KT, Vera D, Ross RS,

Nigam SK. 1 integrin is reqired for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol, 297:F210-F217, 2009.

82. Vallon V, Schroth J, Lang F, Kuhl D, Uchida S. Expression and phosphorylation of the

NaCl-cotransporter NCC in vivo is regulated by dietary salt, potassium and SGK1. Am J Physiol Renal Physiol, 297:F704-F712, 2009.

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Original publications: (continued) 83. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD,

Vallon V. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2 receptor tone. FASEB J, 24:2056-65, 2010.

84. Satriano J, Mansoury H, Deng A, Sharma K, Vallon V, Blantz RC, and Thomson SC.

Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Am J Physiol Cell Physiol, in press, 2010.

85. Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. Lack

of early proximal tubular glucose reabsorption in transgenic Sglt2 null mice. J Am Soc Nephrol, in press, 2010.

86. Stockand JD, Mironova, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O.

Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol, in press, 2010.

Original publications without “peer review”: 1. Vallon V, Chen M, Yang T, Briggs J, Schnermann J. Molecular and functional evidence for

expression of adenosine receptors in zebrafish, Danio rerio. Mt Des Island Biol L 39:33-34, 2000. 2. Chen M, Vallon V, Smart A, Endo Y, Schnermann J, Briggs JP. Studies of the zebrafish

(Danio rerio) renin-angiotensin system. Mt Des Island Biol L 39: 35-36, 2000. 3. Endo Y, Chen M, Vallon V, Schnermann J, Briggs JP. Expression of cathepsin D and

angiotensinogen in nephrons of zebrafish kidney. Mt Des Island Biol L 39:31-32, 2000. Identification and Sequencing of Genes: 1. DEFINITION: Danio rerio cathepsin D precursor (catD) mRNA, complete cds. ACCESSION: AY050516 AUTHORS: Chen M, Vallon V, Smart J, Smart A, Endo Y, Schnermann JB, Briggs JP TITLE: Cathepsin D is Responsible for Angiotensin Generation in Zebrafish JOURNAL: Unpublished 2. DEFINITION: Danio rerio angiotensinogen precursor, mRNA, complete cds. ACCESSION: AY049731 AUTHORS: Chen M, Vallon V, Schnermann JB, Endo Y, Smart J, Smart A, Briggs JP TITLE: Cathepsin D is responsible for angiotensin generation in zebrafish JOURNAL: Unpublished

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Reviews/Commentaries: 1. Blantz RC, Lortie M, Vallon V, Gabbai F, Parmer R, Thomson S. Activities of nitric oxide in

normal physiology and uremia. Seminars in Nephrology, 16:144-150, 1996. 2. Osswald H, Vallon V, Mühlbauer M. Role of adenosine in tubuloglomerular feedback and

acute renal failure. J Autonom Pharmacol, 16:377-380, 1996. 3. Osswald H, Mühlbauer M, Vallon V. Adenosine and tubuloglomerular feedback. Blood Purif 15:243-252, 1997. 4. Thomson SC, Vallon V, Blantz RC. Resetting protects efficiency of tubuloglomerular

feedback. Kidney Int, Suppl. 67:S65-S70, 1998. 5. Vallon V, Osswald H, Blantz RC, Thomson SC. Luminal signal in tubuloglomerular

feedback: What about potassium? Kidney Int, Suppl. 67:S177-S179, 1998. 6. Blantz RC, Deng A, Lortie M, Munger K, Vallon V, Gabbai FB, Thomson SC. The complex

role of nitric oxide in the regulation of glomerular ultrafiltration. Kidney Int 61:782-785, 2002. 7. Vallon V. Tubuloglomerular feedback in the kidney: insights from gene-targeted mice. Eur J Physiol 445:470-476, 2003. 8. Vallon V, Blantz RC, Thomson SC. Glomerular hyperfiltration and the salt paradox in early

diabetes mellitus: a tubulo-centric view. J Am Soc Nephrol 14:530-537, 2003. 9. Lang F, Henke G, Embark H, Waldegger S, Palmada M, Böhmer C, Vallon V. Regulation

of channels by the serum and glucocorticoid-inducible kinase: implication for transport, excitability and cell proliferation.

Cell Physiol Biochem 13:41-50, 2003. 10. Vallon V. In vivo studies of the genetically modified mouse kidney. Nephron Physiol 94:P1-5, 2003. 11. Vallon V. Tubuloglomerular feedback and the control of glomerular filtration rate. News Physiol Sci 18:169-74, 2003. 12. Thomson SC, Vallon V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis

of glomerular filtration. Am J Physiol: Renal Physiol 286:F8-F15, 2004. 13. Vallon V, Wulff P, Huang D, Loffing J, Voelkl H, Kuhl D, Lang F. Role of sgk1 in salt and

potassium homeostasis. Am J Physiol: Regul Integr Comp Physiol 288: R4-R10, 2005.

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Reviews/Commentaries: (continued) 14. Lang F, Vallon V, Grahammer F, Böhmer C, Palmada M. Transport regulation by the serum

and glucocorticoid inducible kinase SGK1. Biochem Soc Transactions, 33:213-5, 2005. 15. Vallon V, Lang F. New insights into the role of serum- and glucocorticoid-inducible kinase

SGK1 in the regulation of renal function and blood pressure. Curr Opin Nephrol Hypertens, 14:59-66, 2005. 16. Vallon V, Blantz RC, Thomson S. The salt paradox and its possible implications in

managing hypertensive diabetic patients. Current Hypertension Reports, 7:141-7, 2005. 17. Hummler E, Vallon V. Lessons from mouse mutants of ENaC and its regulatory proteins. J Am Soc Nephrol, 16:3160-3166, 2005. 18. Satriano J, Vallon V. Primary kidney growth and its consequences at the onset of diabetes

mellitus. Amino Acids, 31:1-9, 2006. 19. Vallon V, Muhlbauer B, Osswald H. Adenosine and kidney function. Physiol Rev, 86:901-40, 2006. 20. Lang F, Böhmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V.

(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.

Physiol Rev, 86:1151-1178, 2006. 21. Blantz RC, Vallon V. Tubuloglomerular feedback responses of the downstream efferent

resistance: unmasking a role for adenosine? Kidney Int, 71:837-839, 2007. 22. Lang F, Vallon V, Knipper M, Wangemann P. Functional significance of channels

expressed in the inner ear and the kidney. Am J Physiol Cell Physiol, 293:C1187-2, 2007. 23. Vallon V. P2 receptors in the regulation of renal transport mechanisms. Am J Physiol Renal Physiol, 294:F10-27, 2008. 24. Vallon V, Miracle C, Thomson S. Adenosine and kidney function: potential implications in

the patients with heart failure. Eur J Heart Failure, 10:176-87, 2008. 25. Vallon V. Regulation of the Na-Cl cotransporter NCC by dietary NaCl: a role for WNKs,

SPAK, OSR1, and aldosterone. Kidney Int, 74:1373-1375, 2008. 26. Vallon V. Techniques to study nephron function: Micropuncturing the Nephron. In “A Molecular Guided Tour Along the Nephron”. Eur J Physiology, 458:189–201, 2009. 27. Rieg T, Vallon V. ATP and adenosine in the local regulation of water transport and

homeostasis by the kidney. Am J Physiol: Regul Integr Comp Physiol, 296:R419-R427, 2009.

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Reviews/Commentaries: (continued) 28. Lang F, Artunc F, Vallon V. The physiological impact of the serum- and glucocorticoid-

inducible kinase SGK1. Current Opinion in Nephrology and Hypertension, 18:439-448, 2009. 29. Lang F, Görlach A, Vallon V. Targeting SGK1 in diabetes. Expert Opin Ther Targets, 13:1303-11, 2009. 30. Vallon V, Sharma K. Sodium-glucose transport: role in diabetes mellitus and potential clinical

implications. Current Opinion in Nephrology and Hypertension, accepted, 2010 Book chapters and Books: 1. Osswald H, Vallon V. Tubuloglomerular feedback and its role in acute renal failure. In: Critical Care Nephrology, C. Ronco and R. Bellomo, editors; Kluwer academic

publishers, pp 613-622, 1998. 2. Vallon V, Schnermann J. Tubuloglomerular feedback. In: Methods in Molecular Medicine: Renal Disease. Guide to Technical Approaches. M.S.

Goligorski, editor; Humana Press Inc. Totowa, New Jersey. Methods Mol Med 86:429-441, 2003. 3. Osswald H, Vallon V, Luippold G, Gleiter C. Diuretika. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 2004. 4. Osswald H, Vallon V. Adenosine and tubuloglomerular feedback in the pathophysiology of

acute renal failure. In: Critical Care Nephrology, C. Ronco, R. Bellomo, J.A. Kellum, editors; Saunders Elsevier, Philadelphia, pp128-134, 2009.

5. Vallon V, Osswald H. Adenosine receptors and the kidney. In: Handbook of Experimental Pharmacology 193: Adenosine Receptors in Health and

Disease, C.N. Wilson and S.J. Mustafa (eds.), DOI 10.1007/978-3-540-89615-9 15, Springer-Verlag Berlin Heidelberg, pp 443-470, 2009.

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TEACHING ACTIVITIES Teaching constitutes an important aspect of my academic activities. Therefore, in 2002/2003 I completed the course „Academic Teaching in Medicine“ (Zertifikat Hochschullehre Medizin, Baden Wuerttemberg, Germany), which was provided by the Center of Academic Didactics of Medicine (Medical Faculties of the Universities of Tübingen, Freiburg and Ulm). This course comprises a total of 200 hours (each hour 45 min) and includes problem-based learning, microteaching and video-feedback as well as integrated coaching sessions with colleagues, which help to reflect and improve the personal teaching technic. Central aspects of my teaching philosophy include: a) to aim for an integrative understanding of medicine (from physiology to pathophysiology to pharmacotherapy), which is required for the future physicians to appropriately respond to the individual and complex problems of a given patient, and b) to stress the active participation of students in teaching activities. The positive evaluations of my teaching activities indicate to me that the students are receptive to this approach. A) University of Tübingen ST: summer term; WT: winter term Course of General and Systematic Pharmacology and Toxicology for Medical Students (3. year) - coronary artery disease and heart failure - diuretics and antihypertensives 18 hours per term: ST 1992 - ST 1993, WT 1995/96 to ST 2003 Course of Clinical Pharmacology for Medical Students (5. year): - basics of pharmacotherapy - heart failure - coronary artery disease - arterial hypertension and hypotension - diseases of the lungs - diseases of the gastrointestinal tract - psychological diseases - diabetes mellitus - pain therapy 18 hours per term: ST 1997 to ST 2003 Lecture on Pharmacology for Dental Medicine Students (4. year): - cardiovascular diseases - gastrointestinal tract diseases 3 hours per term: ST 2002 to ST 2003 Curriculum Kidney for Medical Students (together with physicians of Internal Medicine) (3. year): - acute renal failure - water and electrolyte balance 1 hour per term: ST 2000 to ST 2003 Clinical Pharmacology at the Bedside for Medical Students (5. year): 2 hours per term: ST 2002

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TEACHING ACTIVITIES (continued) Course of Pharmacology for Biology Students (4. year): - physiology and pharmacology of glomerular hemodynamics and transport processes in the kidney: principles of diuretic actions. 8 hours per term: ST 1993, ST 1997, WT 1997/98, WT 1998/99, ST 2000 to 2003. B) University of California San Diego Department of Pharmacology “Principles of Pharmacology” for Medical Students (1. Year): - pharmacokinetic workshop - autonomic pharmacology workshop - vasodilator workshop 6 hours per year: since 2003/04. Department of Pharmacy “Contemporary Topics in Pharmacology” for Pharmacy Students (3. Year): - hyperlipoproteinemia - fluid retention/edema - heart failure 8 hours per year: since 2004/05. Department of Bioengineering “Renal Physiology” for Bioengineering Students: - genetic manipulations to reveal physiological functions 1 hour per year: 2006/07, 2007/08. Department of Medicine “Renal Organ Physiology” for Medical and Pharmacy Students: Case discussions 4 hours per year: since 2007/08. Biomedicine / Pharmacy “Drugs and Disease” for Graduate Students: Lecture 2 hours per year: since 2008/09

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ADVISER AND MENTORING OF MD AND PhD THESES Ph.D. Thesis: - Imke Pfaff (1994) - Dan-Yang Huang (1996) - Xin Nie (1997) - Lijun Yao (1999) M.D. Thesis: - Dorothee Kirschenmann (2000) - Ines Brenner (2000) - Doreen Blach (2001) - Kathrin Pangidis (2003) - Stephanie Redling (2003) - Claudia Birk (2005) MENTORING OF POST-DOCS - Dan-Yang Huang, Ph.D. (1996-2003) (received independent funding in 2004 from German Research Association) - Timo Rieg, MD (since 2003) (received fellowship from German Research Association 2004-2007; received fellowship from National Kidney Foundation 2008-2009; winner of the DSI-sponsored Trainee Award of the Water and Electrolyte Homeostasis Section, American Physiological Society 2008; Renal Research Recognition Award, Renal Section, American Physisology Society 2009; Scientist Development Grant, AHA 2010; Assistant Professor, UC San Diego, 2010)

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SCIENTIFIC SEMINARS AND ORAL PRESENTATIONS:

1. Vallon V, Osswald H. Early changes of kidney function in streptozotocin (STZ)-diabetes in rats: effect of dipyridamole. 34th Spring Meeting German Society of Pharmacology and Toxicology, Mainz, 3/1993.

2. Vallon V. Effect of dipyridamole on kidney function in experimental diabetes mellitus.

Seminar (Host: Prof. Dr. med. Teut Risler), Department of Medicine, University of Tübingen, 4/1993.

3. Vallon V, Meyer J, Schenk F, Osswald H. Reduced activity of tubuloglomerular feedback in

diabetic rats and its normalization by dipyridamole. XII Int. Congress of Nephrology, Jerusalem, Israel, 6/1993.

4. Vallon V, Thomson S, Peterson OW, Gabbai FB, Blantz RC. Interactive control of renal

function by α2-adrenergic system and nitric oxide: role of angiotensin II. Clinical Research Meeting, American Society for Clinical Investigation, Baltimore, MD, 4/1994.

5. Vallon V, Blantz RC, Thomson S. Increased tubular flow induces resetting of tubuloglomerular feedback. Annual Meeting, West Coast Salt and Water Club, Morro Bay, CA, 3/1995.

6. Vallon V. Pathophysiology of kidney function in experimental diabetes mellitus. Nephrology

Seminar (Hosts: Roland C. Blantz, M.D., Dan O‘Connor, M.D.), Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, 5/1995.

7. Vallon V. Studies on tubuloglomerular feedback in experimental diabetes mellitus.

Seminar on Kidney Disease and Hypertension (Host: Prof. Dr. med. Rahn), Department of Medicine, University of Münster, 9/1995.

8. Vallon V, Heyne N, Osswald H. Intratubular angiotensin 1-7 does not affect

tubuloglomerular feedback. 37th Spring Meeting German Society of Pharmacology and Toxicology, Mainz, 1996.

9. Vallon V, Osswald H, Thomson S. Blockade of ATP-sensitive potassium channels inhibits

tubuloglomerular feedback. 27. Annual Meeting German Society of Nephrology, Berlin, 1996.

10. Vallon V, Osswald H, Thomson S. Studying the role of intratubular potassium in

tubuloglomerular feedback by using K channel blocker U37883A. 38th Spring Meeting German Society of Pharmacology and Toxicology, Mainz, 1997.

11. Vallon V. New aspects on the physiology of the tubuloglomerular feedback. Seminar (Host: Prof. Dr. med. Dieter Häberle), Department of Physiology, Maximillian

University Munich, 3/1997. 12. Vallon V. Tubuloglomerular feedback in experimental diabetes mellitus. Annual Meeting Vascular Disease Section Tübingen, Blaubeuren, 5/1997. 13. Vallon V. Pathophysiology of glomerular hyperfiltration in experimental diabetes mellitus. Seminar Kidney Disease and Hypertension (Host: Prof. Dr. rer. nat. Sebastian Bachmann),

University Clinic Charité, Medical Faculty Humboldt-University, Berlin, 7/1997.

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SEMINARS AND ORAL PRESENTATIONS: (continued) 14. Vallon V. Salt diet and kidney function in experimental diabetes mellitus.

1. Symposium of the Interdisciplinary Clinical Research Center Tübingen, Blaubeuren, 11/1997.

15. Vallon V. Tubuloglomerular feedback in diabetes mellitus.

FASEB Summer Research Conference on Renal hemodynamics (Hosts: John Hall, M.D., Jürgen Schnermann, M.D.), Saxton River, VT, 6/1998.

16. Vallon V, Richter K. Glomerular hyperfiltration in experimental diabetes mellitus: Potential

role of tubular reabsorption. 29. Annual Meeting German Society of Nephrology, Erlangen, 1998.

17. Vallon V. Control of glomerular filtration rate in experimental diabetes mellitus.

Joint Meeting of the German Society for Clinical Microcirculation and Hemorheology and Vascular Disease SectionTübingen, Tübingen, 9/1998.

18. Vallon V. Tubuloglomerular feedback: pathophysiological role in glomerular hypofiltration

and hyperfiltration. Seminar (Host: Prof. Dr. med. Michael Schwarz), Department of Toxicology, University of Tübingen, 10/1998.

19. Vallon V. Control of kidney function by tubuloglomerular feedback: studies on the luminal

signal and the signal transduction. Seminar (Host: Prof. Dr. rer. nat. Heimo Kroemer), Department of Pharmacology, University of Greifswald, 11/1998.

20. Vallon V. Tubular reabsorption: studies on the effect of angiotensin 1-7 and on its

pathophysiological role in diabetes mellitus. Seminar der Disease Group Cardiovascular (Host: Priv.-Doz. Dr. rer. nat. Andreas Busch), Hoechst Marion Roussel Deutschland GmbH, Frankfurt a. M., 3/1999.

21. Vallon V. Diabetic nephropathy: pathophysiological aspects and therapeutical options. Seminar (Host: Prof. Dr. rer. nat. Ernst Schleicher), Medical Clinics, University of

Tübingen, 4/1999. 22. Vallon V, Schnermann J. Role of aquaporin-1 in renal function: New insights derived from

micropuncture studies in aquaporin-1 null mice. Seminar (Host: Josie Briggs, M.D., Mark Knepper, Ph.D.), NIDDK, National Institutes of

Health, Bethesda, MD, 10/1999. 23. Vallon V. Glomerular hyperfiltration in diabetes mellitus: Potential role of tubular

reabsorption. Molecular Physiology of Renal Sodium, Urea, and Water Transport (Host: Mark Knepper), NIDDK, National Institutes of Health, Bethesda, MD, 11/1999.

24. Vallon V. Mikropuncture in mice.

Seminar, Pharmacological Institute, University of Tübingen, 1/2000. 25. Vallon V, Schnermann J. Macula densa-mediated reduction of nephron filtration rate in

bNOS knockout mice. 79. Annual Meeting German Society of Physiology, Ulm, 3/2000.

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SEMINARS AND ORAL PRESENTATIONS: (continued) 26. Vallon V, Schnermann J. Role of bNOS in macula densa: Micropuncture studies in rats

and bNOS knockout mice. Seminar (Hosts: Robert Star, M.D., Josie Briggs, M.D.), NIDDK, National Institutes of Health, Bethesda, MD, 4/2000.

27. Vallon V. Role of potassium and potassium channels in renal function: New insights from

micropuncture studies employing various potassium channel blockers. Seminar (Host: Gerhard Giebisch, M.D.), Yale University, Department of Cellular and Molecular Physiology, New Haven, CT, 4/2000.

28. Vallon V, Verkman AS, Schnermann J. Luminal hypotonicity in proximal tubule and flow

dependence of loop of Henle fluid absorption in aquaporin-1 knockout mice. Experimental Biology Meeting, FASEB, San Diego, CA, 4/2000.

29. Vallon V. Diabetic nephropathy: pathophysiological aspects and therapeutical options.

Seminar (Host: Dr. M. Schramm), Institute for Cardiovasular Research, Bayer AG, Wuppertal, 5/2000.

30. Vallon V, Barhanin J, Richter K. Transport along the nephron in IsK knockout mice. Annual Meeting German Society of Nephrology, Wien, 9/2000. 31. Vallon V. Control of kidney function by tubuloglomerular feedback: new insights on

physiology and pathophysiology. Institute for Normal and Pathological Physiology, University of Marburg, 11/2000.

32. Vallon V. Role of protein kinase C isoforms in kidney function and diabetic nephropathy.

Seminar on the phenotypic analysis of protein kinase C knock-out mice. (Hosts: Dr. M. Leitges and Prof. H. Haller), Max-Planck-Institut for Experimental Endocrinology and Medical University of Hannover, Department of Nephrology, Center for Internal Medicine, Hannover, 3/2001.

33. Vallon V. Role of aquaporin-1 and KCNE1 in proximal tubule: studies in knockout mice.

Seminar (Hosts: Prof. Heini Murer and Prof. Brigitte Kaissling), Institutes of Physiology and Anatomy, University of Zürich, 4/2001.

34. Vallon V. Diabetic Nephropathie: new aspects on pathophysiology and therapy.

Institute of Pharmacology, University of Heidelberg-Mannheim, 4/2001. 35. Vallon V, Deng A, Bao D, Satriano J, Blantz RC,Thomson SC.

Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. Annual Meeting German Diabetes Society, Aachen, 5/2001.

36. Vallon V. Pathophysiology of glomerular hyperfiltration in experimental diabetes mellitus.

Annual Meeting Vascular Disease Section Tübingen, Tübingen, 6/2001. 37. Vallon V. Specific rat strains and knock-out mice to delineate the pathophysiology of

diabetic nephropathy. Institute of Pharmacology and Toxicology, University of Tübingen, 7/2001.

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SEMINARS AND ORAL PRESENTATIONS: (continued) 38. Vallon V. Role of KCNQ1 and KCNE1 in kidney function. Invited Lecture. Symposium “Clinical and experimental aspects of cloned potassium

channels in the kidney” (Hosts: Dr. JR Hirsch, Dr. M. Bleich) Annual Meeting of the German Society of

Nephrology, Münster, 9/2001. 39. Vallon V. Role of KCNQ1 and KCNE1 in kidney function.

Symposium “10 Years Department of Pharmacology University of Tübingen 1991-2001", Tübingen, 10/2001.

40. Vallon V. Pathophysiology of glomerular hyperfiltration in the early phase of diabetes

mellitus. Seminar (Host: Karl Hilgers, MD), University of Erlangen-Nürnberg, 11/2001.

41. Vallon V. Tubulo-glomerular communication in the kidney.

Institute of Physiology, University of Heidelberg, 12/2001. 42. Vallon V, Wulff P, Huang DY, Völkl H, Richter K, Klingel K, Loffing J, Kauselmann G, Lang

G, Kuhl D. Impaired renal Na+ retention in the sgk1-knockout mouse. Invited Lecture, 81. Annual Meeting German Society of Physiology, Tübingen, 3/2002.

43. Vallon V. Tubulo-glomerular feedback in the kidney: insights from transgenic mice.

Invited Lecture. Pflügers Archiv International Workshop and EKRA Post-graduate course on functional genomics: "Mouse models for human diseases : a critical appraisal", (Organizers B. Rossier, E. Hummler, H. Murer, F. Lang) Tübingen, 3/2002.

44. Vallon V. Regulation of renal sodium transport and blood pressure: lessons from sgk1

knockout mice. Seminar (Host: Edith Sim), Department of Pharmacology, University of Oxford, 7/2002.

45. Vallon V. Mechanisms of tubular sodium transport.

Invited Lecture, Annual Meeting German Society of Nephrology, Düsseldorf, 9/2002. 46. Vallon V, Wulff P, Huang DY, Völkl H, Richter K, Klingel K, Loffing J, Kauselmann D, Lang

F, Kuhl D. Impaired renal sodium retention in the sgk1-knockout mouse. Annual Meeting Am. Soc. Nephrol., Philadelphia, PA, 10/2002.

47. Vallon V. Regulation von renaler Natriumreabsorption und Blutdruck: Neue Einblicke durch Untersuchungen an SGK1-defizienten Mäusen. Seminar, Institute of Pharmacology, University of Essen, 11/2002.

48. Vallon V., Huang D.Y., Gerlach U., Richter K. HMR1556, a blocker of potassium channel forming KCNQ1, inhibits glucose absorption in proximal tubule. 44. Spring Meeting, German Society of Pharmacology and Toxicology, Mainz, 3/2003.

49. Vallon V, Huang DY, Richter K, Schnermann J. Nephron function in adenosine A1 receptor-deficient mice. Annual Meeting Am. Soc. Nephrol., San Diego, CA, 11/2003.

50. Vallon V, Huang DY, Wulff P, Richter K, Kuhl D, Lang F. Effect of desoxycorticosterone acetate (DOCA) on the kidney and blood pressure in SGK1-deficient mice.

Annual Meeting Am. Soc. Nephrol., San Diego, CA, 11/2003.

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SEMINARS AND ORAL PRESENTATIONS: (continued)

51. Vallon V. Regulation von Natriumhaushalt und Blutdruck: Bedeutung von sgk1. Institute of Pharmacology and Toxicology, University of Dresden, 3/2004. 52. Vallon V. Role of sgk1 in Na+ and K+ homeostasis: insights from the knockout mouse.

Invited Lecture, Experimental Biology Meeting, Washington D.C., 4/2004.

53. Vallon V, Richter K, Huang DY, Bindels R, Hoenderop J. TRPV5 mediates Ca2+ reabsorption in distal convolution. Experimental Biology Meeting, Washington D.C., 4/2004.

54. Vallon V. Role of sgk1 in salt and potassium homeostasis: insights from the knockout mouse. Renal Conference, Division of Nephrology & Hypertension, School of Medicine, UC San Diego, 6/2004.

55. Vallon V. Pathophysiologie und Pharmakologie der Niere und des Herzkreislaufsystems:

Regulation von Salzhaushalt und Blutdruck durch Sgk1. Institute of Pharmacology, University of Erlangen, 8/2004.

56. Vallon V, Eraly S, Richter K, Monte JC, Vaughn D, Nigam S. Role of organic anion transporter OAT3 in the natriuretic response to furosemide. 46. Spring Meeting, German Society of Pharmacology and Toxicology, Mainz, 3/2005.

57. Vallon V. Role of K+ channel KCNQ1/KCNE1 in renal function Renal Conference, Division of Nephrology & Hypertension, School of Medicine, UC San Diego, 4/2005.

58. Vallon V. Role of potassium channels in electrogenic sodium reabsorption in proximal tubule. Invited Lecture, XXXV International Congress of Physiological Sciences; "Coordinating Hemodynamic, Filtration, and Reabsorptive Functions of the Kidney", San Diego, 4/2005.

59. Vallon V. K+ channels and transport in the kidney: insights from mice lacking KCNQ1/KCNE1, TWIK-1 or SGK1. Seminar, Yale University, Dept. of Cellular and Molecular Physiology, New Haven, 6/2005.

60. Vallon V, Volkl H, Richter K, Pfeifer K. Role of K+ channel KCNQ1 in electrogenic Na+ reabsorption of mid to late proximal tubule. Annual Meeting Am. Soc. Nephrol., Philadelphia, PA, 11/2005.

61. Vallon V. Mechanisms of distal tubular Ca2+ reabsorption and of hypocalciuria induced by thiazides or a mouse model for Gitelman's syndrome. Renal Conference, Division of Nephrology & Hypertension, School of Medicine, UC San Diego, 11/2005.

62. Vallon V. Transport mechanisms along the nephron: insights from gene-targeted mice. Keynote Lecture. Annual Meeting West Coast Salt and Water Club, Morro Bay, CA,

3/2006. 63. Vallon V. Tackling issues of renal pharmacokinetics and pharmacodynamics by using

gene-targeted mice. Seminar, Department of Pharmacology and Toxicology, University of Lausanne,

Switzerland, 3/2006.

V. Vallon

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SEMINARS AND ORAL PRESENTATIONS: (continued) 64. Vallon V. Pharmacology of the kidney – from gene to function. PRISM (Progress in the Science of Medicine)-Lecture, University of California San Diego,

4/2006. 65. Vallon V. SGK1 as a determinant of salt intake, blood pressure, renal damage and cardiac

fibrosis in response to mineralocorticoid excess. Keynote Lecture. International Society of Hypertension, Symposium on "Aldosterone and

Hypertension", Tokyo, Japan, 10/2006. 66. Vallon V. Mechanisms of fluid and electrolyte transport along the nephron: lessons from

genetic mouse models. Invited Lecture, Young Investigator Award, Renal Section, American Physiological Society,

Experimental Biology Meeting, Washington D.C., 4/2007. 67. Vallon V. Glomerular hyperfiltration and the salt paradox in early diabetes mellitus: a

tubulo-centric view. Invited Lecture, World Congress of Nephrology/ISN Meeting, Rio de Janeiro 4/2007

68. Vallon V. Adenosine and the kidney. Invited Lecture, Heart Failure Meeting, European Society of Cardiology, Hamburg, 6/2007. 69. Vallon V. Role of SGK1 in salt and potassium homeostasis. Invited Lecture, FASEB Summer Conference, “Renal Hemodynamics – Biomolecular

Control Mechanisms Integrating Vascular and Tubular Function,” Saxton’s River, VT, 7/2007.

70. Vallon V, Hummler E, Rieg T, Schroth J, Cheng VPC, Rossier B, Cunard R. Collecting

duct-specific gene inactivation of ENaC in the mouse kidney does not attenuate rosiglitazone-induced weight gain.

Experimental Biology Meeting, San Diego, CA, 4/2008. 71. Vallon V. P2Y2 receptors in the regulation of renal transport mechanisms. Invited Lecture. PURINES 2008; Copenhagen, Denmark, 6/2008. 72. Vallon V. Glomerular hyperfiltration and the salt paradox in early diabetes mellitus: a

tubulo-centric view. Invited Lecture. Annual Meeting German Society of Nephrology, Tuebingen, Germany,

9/2008. 73. Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn S-Y, Mahapatra NR,

Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK. Lowered blood pressure in organic anion transporter 3-null mice.

Annual Meeting German Society of Nephrology, Tuebingen, Germany, 9/2008. 74. Vallon V, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Insel PA, Stockand J. ENaC open-

probability and DOCA-induced salt-sensitivity of blood pressure are enhanced in mice lacking P2Y2 receptors.

Annual Meeting German Society of Nephrology, Tuebingen, Germany, 9/2008. 76. Vallon V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B,

Cunard R, Stockand J. Collecting duct-specific gene inactivation of ENaC in the mouse kidney does not attenuate rosiglitazone-induced fluid retention

Annual Meeting Am. Soc. Nephrol., Philadelphia, PA, 11/2008.

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SEMINARS AND ORAL PRESENTATIONS: (continued) 77. Vallon V, Schroth J, Satriano J, Blantz RC, Thomson SC, Rieg T. Adenosine A1 receptors

are essential to glomerular hyperfiltration and the salt paradox in early streptozotocin-diabetes mellitus.

Annual Meeting Am. Soc. Nephrol., Philadelphia, PA, 11/2008. 78. Vallon V. Regulation of renal epithelial transport by P2Y2 receptors. Division of Nephrology, University of Southern California, Los Angeles, CA, 5/2009. 79. Vallon V. Regulation of epithelial sodium channel ENaC by P2Y2 receptors. Department of Medicine, University of Lübeck, Germany, 5/2009. 80. Vallon V. Glomerular hyperfiltration and the salt paradox in early diabetes mellitus – a

tubulocentric concept. Invited Lecture. F. Hoffmann-La Roche AG, Basel, 6/2009. 81. Vallon V. Physiology and pharmacology of organic anion transporters: investigations with

genetically modified mouse models. Invited Lecture. Annual Meeting German Society of Nephrology, Goettingen, Germany,

9/2009. 82. Vallon V. Molecular determinants of renal transport: studies in gene-targeted mice. Invited Lecture. Department of Medicine, University of Erlangen-Nürnberg, Germany,

9/2009. 83. Vallon V. Regulation of water transport in the collecting duct: New insights from gene-

targeted mice. Invited Lecture, FASEB Summer Conference, “Renal Hemodynamics”, Saxton’s River, VT,

6/2010.