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Volume 15 Lipid Soft Tissue Tumors
Superficial lipomas-------------Case 1183
Intramuscular lipomas----------Case 270-274 & 1184-1190
Spindle cell lipomas------------Case 275-276
Angiolipomas--------------------Case 277-278 & 1191-1196
Ossifying lipoma----------------Case 1196.1-1196.3
Myxolipomas--------------------Case 279
Diffuse lipomatosis-------------Case 280
Lumbosacral lipoma------------Case 281
Hibernoma-----------------------Case 1197
Liposarcoma
Well differentiated------------Case 283 & 1198
Myxoid-------------------------Case 285-289 & 1199-1201
Round cell---------------------Case 290
Pleomorphic-------------------Case 291 & 1202-1203
Vascular Soft Tissue Tumors
Hemangioma---------------------Case 292-298 & 1204-1211
Hemangiomatosis---------------Case 299-300 & 1212
Lymphangioma------------------Case 301-304 & 1213
Glomus tumor-------------------Case 305-307
Hemangiopericytoma-----------Case 308-311
Kaposi’s sarcoma----------------Case 312-313
Angiosarcoma--------------------Case 314
Lipid Tumors
Superficial Lipoma
Superficial Lipomas
Lipomas are by far the most common soft tissue tumor encountered
in orthopedic oncology. There is a large number of variants, the most
common being the superficial subcutaneous lipoma that occurs in
both males and females in an older age group, the 5th and 6th decade
of life. Typical lesions are seen in the back, shoulder and neck. On
palpation, these tumors have a soft non-tender characteristic. They
occur more commonly in obese patients, however, when patients
lose weight dramatically, the size of the lipoma will not vary. In
older patients they grow quite rapidly at first but then stop. They
never convert into a malignant tumor at some later date. Surgical
treatment usually consists of a cosmetic resection and the recurrence
rate is less than 5%.
Case #1183
51 year male with superficial lipoma arm
Coronal T-1 MRI
Another coronal T-1 MRI
tumor
Axial T-1 MRI
tumor
Surgical specimen
Photomic
Case #1183.1
71 year female with recent shoulder dislocation and history of a soft
tissue lump over back of shoulder for years
Superficial lipoma
Axial T-1 Gad
Case #1183.2 Superficial lipoma
Axial T-1 PD FS
42 yr male with one yr history of painless lump on shoulder
Intramuscular
Lipomas
Intramuscular Lipoma
The intramuscular lipoma occurs in adults between the ages of
30 and 60 years, and is usually found in the larger muscle groups.
The tumor occurs quite gradually, without symptoms of pain, and
does not cause disability when left untreated. It is usually
recognizable on routine radiographic exam, showing a well-
marginated lesion with a radiodensity less than that of the
surrounding muscle. However, the best imaging study for a lipoma
of muscle is the MRI which shows a diagnostic high signal,
lobulated lesion on the T-1 weighted image that has the exact
same appearance as the subcutaneous fat. On the T-2 image, the
lesion will be an intermediate signal and again have the exact
appearance of subcutaneous fat. Histologically, the intramuscular
lipoma demonstrates large lipocytes with very small pyknotic
nuclei. The pathologist must be very careful to look for evidence of
atypical lipoblasts that would suggest the diagnosis of a well-
differentiated liposarcoma that can coexist with a benign lipoma.
On rare occasion, lipomas can have coexistent chondroid or osseous
hamartomatous elements that in the past had been classified as
mesenchymomas. Surgical treatment for the intramuscular lipoma is
a marginal resection, being careful to avoid damage to the neuro-
vascular structures that might pass through the lipoma. The
recurrence rate is higher than for subcutaneous lipomas and range
between 15 and 60%.
CLASSIC
Case #270
72 year male with an
intramuscular lipoma
quadriceps muscle
Coronal T-1 MRI
Another coronal T-1 MRI
Axial T-1 MRI
Gross specimen
Photomic
Case #270.1
Axial T-1 T-1 STIR
72 year female with painless mass in anterior thigh for years
Intramuscular lipoma
Coronal T-1 Sagittal T-1 Coronal STIR
Case #270.2 Axial T-1 T-2
Gad
56 year male with painless soft
mass in anterior thigh for 2 years
Sag T-1 T-2 FS
Case #270.3
65 year old female with
3 yr history of large painless
mass in posterior thigh
Intraneural lipoma sciatic nerve
Sag T-1 T-2
Axial T-1 PD
Surgical resection
Case #271
74 year female with intramuscular lipoma hand
Coronal T-1 MRI
Axial T-1 MRI
Surgical resection
Photomic
Case #272
47 year female with intramuscular lipoma foot
Sagittal T-1 MRI
Axial T-1 MRI
Coronal T-1 MRI
Case #273
11 year male
lipoma
deltoid muscle
Axial T-1 MRI
Coronal T-1 MRI
Case #273.1
43 year female with soft painless mass in axilla
Axial T-1
T-2
Sag T-1 T-2
Cor T-1
Case #274
67 year male
calcifying necrotic
lipoma
Resected specimen cut in path lab
calcification
Case #1184
58 year female with
intramuscular lipoma
buttock area
Axial T-1 MRI showing lipoma extruding thru the sciatic notch
Coronal T-1 MRI showing lipoma extrusion thru the notch
Surgical specimen
Case #1184.1
51 year old male with soft painless mass in buttocks for 5 yrs
CT scan Lipoma
Axial T-1 T-2
Gad
Cor T-1 T-2
Gad
Sag gad
Case #1185
59 year female with
intramuscular lipoma
anterior proximal thigh
Coronal T-1 MRI
Axial T-2 MRI
Axial T-2 MRI
at lower level
Fat subtraction MRI
showing signal void
in lipoma
Case #1186
51 year male with
intramuscular lipoma
posterior compartment
thigh
Axial T-1 MRI
Case #1187
62 year female with
intramuscular lipoma
adductor compartment
thigh
Coronal T-1 MRI
Surgical exposure of tumor
Case #1188
72 year female with
intramuscular lipoma
mid arm
Axial T-1 MRI
Case #1189
2 year male with
intramuscular lipoma
posterior thigh
AP view
Case #1190
66 year female with intramuscular lipoma forearm
CT scan
tumor
Case #1190.1
55 year female with painless mass in forearm over 1 yr
Intramuscular lipoma
Sagittal MRI
T-1 T-1 PD-FS Gad
Axial T-1
Gad
Surgical resection
Case #1190.2
33 year old female with
painless lump at ankle
for 1 year
Sag T-1 PD Gad
Axial T-1 Gad
Surgical excision
Spindle Cell
Lipomas
Spindle Cell Lipoma
The spindle cell lipoma is seen more commonly in men between
the ages of 45 and 65 years and is typically located in the posterior
neck or shoulder area. MRI imaging demonstrates the high signal
features of a lipoma on the T-1 weighted image but with areas of
lower signal streaking seen throughout the high signal areas where
the fibrous tissue is located. Histologically, the spindle cell lipoma
looks like any other lipoma except for the presence of benign-
appearing fibrous tissue with occasional areas of gelatinous break-
down in the fibrous tissue. The treatment for this variant is a
marginal resection and carries a minimal chance for local recurrence.
CLASSIC Case #275
59 year male with spindle cell lipoma thigh
CT scan
Case #276
64 year male with spindle cell lipoma proximal forearm
Sagittal T-1 MRI
Axial T-1 MRI
Axial proton density MRI
Angiolipomas
Angiolipoma
The angiolipoma is another variant of the lipoma occurring usually
in subcutaneous locations in young adult patients. It is seen most
commonly in the forearm. These lesions may be multiple and can be
painful because of their increased vascularity. These lesion can be
seen on routine radiographs when phleboliths are present in the
vascular component, but the most diagnostic imaging study is the
MRI that will show the high signal features of a lipoma on the T-1
weighted image with the additional serpinginous low signal pattern
of vascular tissue streaking throughout the high signal lipomatous
tissue. Treatment for this variant is a simple marginal resection
from which one can expect a relatively low recurrence rate.
CLASSIC Case #277
27 year female with angiolipoma forearm showing
phleboliths and hypertrophic subadjacent radius
phleboliths
Sagittal T-1 MRI showing low signal serpinginous
vessels running thru high signal lipoma tissue
Resection specimen showing serpinginous vessels in fat
Case #278 Coronal T-1 MRI
16 year female with angiolipoma quadriceps muscle
Axial T-1 MRI
Case #1191
24 year female with
angiolipoma anterior
thigh
Sagittal T-1 MRI
Axial T-1 MRI
Coronal T-2 MRI
Sagittal gad
contrast MRI
Case #1192
23 year female with
angiolipoma anterior
to hip joint
Axial T-1 MRI
Sagittal T-1 MRI
Coronal T-1 MRI
Case #1194
41 year male with
angiolipoma thigh
Coronal T-1 MRI
Axial T-1 MRI
Case #1194.1
33 year female with painless mass in anterior thigh 1 year
Axial T-1 MRI
Axial T-2
Axial Gad Contrast
Sagittal T-2 Sagittal Gad
Case #1195
17 year female with
angiolipoma forearm
Sagittal T-1 MRI
Coronal T-1 MRI
Axial T-2 MRI
Case #1196
33 year male with
angiolipoma calf
Axial T-1 MRI
Sagittal T-1 MRI
Ossifying Lipoma
The ossifying lipoma is a very rare variant of the lipoma
with only 12 cases in the literature most of which were
located in the head and neck area. Four extremity cases
were located in the shoulder, thigh and hand in middle aged
patients. Bone and cartilage may be found in the central area
of the lipoma and is thought to be a dysplastic or hamart-
omatous process similar to the mesenchymoma. They are not
attached to bone as in the case of the parosteal lipoma. They
are painless lesions that grow slowly over years and are easy
to resect with little chance of recurrence.
Case #1196.1
75 yr female with painless soft mass in thigh for 10 yrs
Ossifying Lipoma
Axial T-1
Sag T-1 Axial T-2
bone
Necrotic tumor
fat
Surgical removal of the
large mass from the
quadriceps muscle
Photomics show typical
lipoma tissue covering
necrotic ossifying tissue
Post op appearance following resection
Case #1196.2 Ossifying Lipoma
53 yr male with painless
mass in knee for 3 yrs
Cor T-1 Axial T-2
Case #1196.3
60 yr female with painless forearm mass for 2 years
Ossifying lipoma
Sag T-1 T-2 FS Gad
Axial T-1 T-2 FS
Gad
Myxolipoma
CLASSIC Case #279 Sagittal T-1 MRI
63 year female with myxolipoma knee
Sagittal T-2 MRI
Axial T-1 MRI
Diffuse
Lipomatosis
Diffuse Lipomatosis
An extremely rare variant of the lipoma is the diffuse lipomatosis
form seen during the first two years of life. It may involve one
entire extremity or the trunk, demonstrating both superficial and
deep intramuscular, multifocal lesions. Histologically, these lesions
are identical to that of a benign lipoma and because of the massive
involvement of the extremity in some cases, amputation may be
indicated.
CLASSIC Case #280
20 year male with diffuse lipomatosis lower extremities
CT scan
Another CT cut
Lumbosacral
Lipoma
Lumbosacral Lipoma
The lumbosacral lipoma variant is frequently associated with a
spinabifida defect in the spine and can be seen in both the pediatric
and adult age group. These lesions can be associated with both intra-
dural and extradural lipomas and can result in neurological deficiency.
The MRI image will show the characteristic high signal response
on the T-1 weighed image, like all other forms of lipomas. Treatment
consists of a marginal surgical resection, including the lesions within
the vertebral canal. A low recurrence rate is anticipated.
CLASSIC
Case #281
Sagittal T-1 MRI
lumbosacral lipoma
61 year male
Axial T-1 MRI
Synovial Lipoma
Case #281.1
26 year male with injury to shoulder 6 years ago
Synovial lipoma
Axial T-1
Axial T-2
Cor T-1
Cor T-2
Sag T-2
Case #281.2 Synovial lipoma knee Axial
T-1 T-2
Gad
48 year old female with
tender lump over medial
retinaculum for l year
Coronal T-1 T-2 Gad
Sagittal T-1 T-2 Gad C+
Hibernoma
Hibernoma
The hibernoma is a very rare lipoma variant seen usually in young
adults in the intrascapular area of the back. It is painless and slow
growing and ranges between 10 and 15 cm in diameter. Histolo-
logically, the hibernoma demonstrates fine granular or vaculated
cells consisting of brown fat and large amounts of glycogen. The
treatment for this lesion is simple marginal resection with a very
low potential for local recurrence.
Case #1197
CLASSIC
37 year female with
hibernoma triceps m
Sagittal T-1 MRI
Axial T-1 MRI
Axial T-2 MRI
Axial gad
contrast MRI
Sagittal gad contrast
MRI
Surgical specimen showing tan color
Photomic
Photomic
Case #1197.1
38 year female with painless hibernoma anterior thigh
Sag T-1 MRI Cor T-1 MRI Axial T-1 MRI
Sagittal T-2 MRI Sagittal Gad MRI
Case #1197.2
28 yr male with fullness in groin area for 1 yr
hibernoma
Axial T-1 PD
Gad
Sag PD Sag Gad
Case #1197.3 Axial T-1 Axial T-2 MRI
2.5 yr male with painless buttock lump for 1 year
with tissue diagnosis of lipoblastoma
Coronal T-1 MRI Coronal T-2 MRI
Sagittal T-1 MRI Sagittal T-2 MRI
Liposarcoma
Liposarcoma
Second to the MFH, the liposarcoma is the most common soft
tissue tumor seen in the musculoskeletal system. These tumors are
seen typically in an older population group (over the age of forty)
and are slightly more common in males than females. They are
typically located in large muscle groups, especially in the lower
extremity where 70% of these tumors will be found. There are four
subtypes of liposarcoma, including the well-differentiated form
and the myxoid form that are low grade, and the round cell and
pleomorphic forms that are high grade.
Well-differentiated
Liposarcoma
(Atypical Lipoma)
Well-differentiated Liposarcoma
The well-differentiated liposarcoma is a very low grade variant
of the liposarcoma that looks almost like a benign lipoma. It occurs
in people past the age of 45 years and is commonly seen in the
lower extremity, especially in the buttock and thigh area, but can
also be found in the retroperitoneal portions of the body. On gross
examination, the well-differentiated form looks like a routine intra-
muscular lipoma, but microscopically the pathologist must find a
few areas of low grade lipoblasts with a signet ring appearance
to make this diagnosis. This lesion is sometimes referred to as an
atypical lipoma because its gross appearance is similar to the benign
lipoma. The prognosis for this variant is extremely good but with a
fairly high potential for local recurrence in about 30-50% of cases.
There is essentially no chance of this lesion metastasizing to distant
parts. If located in the retroperitoneal area, it can be fatal because
of the difficulty in removing the tumor.
CLASSIC
Case #283
Coronal T-1 MRI
63 year female
Well-differentiated
liposarcoma thigh
Resected surgical specimen
Case #283.1 Well Differentiated Liposarcoma Thigh
68 yr old male with three time recurrence of soft mass in thigh
Cor T-1 STIR Gad
Axial T-1 STIR
Gad
Case #284
Coronal T-1 MRI
49 year male with
well-differentiated
liposarcoma (atypical lipoma)
distal thigh
Sagittal T-1 MRI
Axial T-2 MRI
Case #1198
62 year male with well-differentiated liposarcoma thigh
Axial T-2 MRI
Coronal T-2 MRI
Case #1198.1
Sag T-1 PD
47 yr old female with mild intermittent pain in thigh 2 yrs
Atypical Lipoma
Axial T-1 PD
Gad
Case #1198.2
Coronal T-1 MRI of
the thigh of a 41 year
male with prior history
of partially resected
atypical lipoma 3 yrs
before
Dedifferentiated lipsosarcoma
Axial PD Axial Gad
Sagittal Gad
Case #1198.3 CT scan 4/06
71 year old male with
painless soft mass in
adductor compartment
in 06 which became
painful with recent
growth in 09
Sag T-1 Gad
09
Axial T-1 upper T-2 upper
T-2 lower Cor STIR
Surgical removal
Case #1198.4 Sag T-1 T-2 FS Gad
45 yr female with atypical lipoma resected from calf 3 yrs ago
Axial T-1 Gad
Tumor resection off the posterior tibial nerve
nerve
Myxoid
Liposarcoma
Myxoid Liposarcoma
The myxoid variant is the most common variant of the lipo-
sarcoma and it is seen in a slightly younger age group between 40
and 50 years of age. It occurs in the lower extremities in 75% of
cases, especially in the popliteal area. These lesions are slow
growing and frequently asymptomatic in the early stages. On
imaging studies, the MRI is the best method for visualizing these
tumors that will have a mixed high and low signal on the T-1
weighted image because of the high percentage of fatty tissue in
the tumor. Histologically, there will be evidence of malignant
lipoblasts and it is common to find a plexiform network of small
capillary tubes running thru the fatty tumor, similar to the capillary
hemangioma. The prognosis for this variant is quite good after a
wide local surgical resection, followed in most cases by local
radiation therapy. The chance of pulmonary metastases runs as
high as 20% and occasionally there will be multifocal myxoid
liposarcomas occurring in the extremities as well as in retro- peritoneal locations. Occasionally, one will see a transitional
form of myxoid converting into a higher grade round cell lipo-
sarcoma which carries a more guarded prognosis.
CLASSIC Case #285 Sagittal T-1 MRI
67 year female with myxoid liposarcoma knee
Sagittal T-2 MRI
Axial T-2 MRI
Resection specimen
Photomic showing lipoblasts and vascular channels
Case #286 Sagittal T-2 MRI
43 year male with myxoid liposarcoma behind knee
tumor
Coronal T-2 MRI
tumor
Axial T-1 MRI
tumor
Surgical resection
Cut specimen
Photomic
vessel
lipoblasts
Case #287
Coronal T-1 MRI
29 year male with
myxoid liposarcoma
posterior thigh
tumor
Axial PD MRI
tumor
Axial T-2 MRI
Wide resection specimen
Photomic showing numerous vascular channels
Case #288 Coronal T-1 MRI
34 year female with myxoid liposarcoma thigh
Coronal T-2 MRI
Axial T-1 MRI
tumor
Axial T-2 MRI
tumor
Photomic
Axial T-2 MRI showing multifocal involvement in abdomen
tumor
kidney
Case #289
Sagittal T-1 MRI
32 year male with
myxoid liposarcoma
distal thigh
tumor
Axial T-1 MRI
tumor
Resected specimen
Specimen cut in path lab
fat
myxoid
Photomic
Case #1199
30 year male with
myxoid liposarcoma
posterior thigh
Sagittal T-1 MRI
Sagittal T-2 MRI
Axial T-1 MRI
tumor
Axial Gad contrast MRI
Coronal Gad
contrast MRI
Surgical specimen
Photomic
Case #1200 Sagittal T-1 MRI
75 year male with myxoid liposarcoma foot
Another sagittal T-1 MRI
Axial T-1 MRI
tumor
Sagittal T-2 MRI
Another sagittal T-2 MRI
Sagittal Gad contrast MRI
Photomic showing lipoblasts
Case #1201
69 year male with myxoid liposarc pelvis
tumor
CT scan
Axial T-2 MRI
Photomic showing lipoblasts and vessels
Case #1201.1
27 year male with
myxoid liposarcoma
vastus intermedius m.
Axial T-1 MRI
Coronal T-1 MRI
Coronal Gad
contrast MRI
showing femoral
artery
Surgical incision including biopsy site
Surgical exposure of tumor contained in muscle fascia
biopsy
Tumor excised including periosteum
Excised tumor mass contained in muscle fascia
biopsy site
Wound closure
Case #1201.2 Axial T-1 STIR
Gad 70 yr female with slightly
tender mass above elbow
for 1 year
Myxoid Liposarcoma Triceps
Sag T-1 STIR Gad
Ulnar N
Surgical resection
Round Cell
Liposarcoma
Round cell and Pleomorphic Liposarcoma
The round cell and pleomorphic liposarcomas are high grade
liposarcomas seen in the same locations as other liposarcomas in
a slightly older age group. They account for about 10% of all
liposarcomas. Because these are high grade they act more like a
high grade MFH with increased pain and rapid growth. On imaging
studies, the higher grade lesions take on the appearance of a more
aggressive sarcoma without the high signal appearance of fat on
the T-1 weighted image. Histologically, there will be evidence of
severe atypicism and bizarre-appearing giant cells with only
occasional areas of lipoblastic signet ring cells that are necessary
to make the ultimate diagnosis. These high grade lesions are treated
by wide surgical resection, followed by postoperative radiation
therapy and occasionally chemotherapy will be indicated for
aggressive lesions in a younger age group. The chance of
pulmonary metastases runs as high as 80% in these high grade
variants.
CLASSIC
Case #290
38 year male with
high grade round cell
liposarcoma thigh
Sagittal T-1 MRI
tumor
Sagittal T-2 MRI
tumor
Axial proton density MRI
tumor
Photomic showing round cells and lipoblasts
Pleomorphic
Liposarcoma
CLASSIC Case #291 Sagittal T-2 MRI
44 year male with pleomorphic liposarcoma knee
tumor
Sagittal T-1 MRI
tumor
Axial gad contrast MRI
tumor
Photomic showing bizarre pleomorphic giant cells
Close up of pleomorphic lipoblasts
Case #1202
80 year male with
pleomorphic liposarcoma
Sagittal T-1 MRI
Sagittal T-2 MRI
Surgical specimen
Photomic
Case #1203
61 year male with
pleomorphic liposarcoma
biceps muscle
Sagittal T-1 MRI
Sagittal T-2 MRI
Case #1203.1
65 year male with recent onset buttock tumor mass in area of previous
resected large benign lipoma 6 years ago
Axial CT scan Pleomorphic liposarcoma
Sag CT scan Cor CT
Axial T-1 T-2
Gad
fluid
tumor
Sag T-2 Surgical specimen
Vascular Tumors
Hemangioma
Hemangioma
After the benign lipoma, the benign vascular tumor is the second
most common soft tissue lesion seen in the human body. Hemangiomas
are developmentally dysplastic neoplasms of the endothelial tube.
They occur most commonly during childhood, more commonly in
females than males, and account for 70% of all benign tumors. The
most common type of hemangioma is the solitary capillary hem-
angioma that appears as an elevated red to purple cutaneous lesion,
usually in the head and neck area. It is usually seen during the first
few weeks after birth. The lesion will grow rapidly for a period of
several months and then disappear spontaneously over a period of
seven years in about 80% of cases. These lesions are essentially
cosmetic and do not deserve any aggressive form of treatment.
However, in the past, attempts at injecting them with sclerosing
agents or liquid nitrogen, or using radiation therapy, made the
situation more disabling than the original lesion. A less common
form of hemangioma is the so-called cavernous hemangioma that
has a purplish-gray appearance and can look similar to varicosities
in the extremities but in a younger age group. They can involve
large muscle groups in the extremity and can even involve synovial
membranes in joints.
Radiographically, the hemangioma may present with small,
punctate, calcific deposits within the tumor that is almost diagnostic
of this condition. These are referred to as phleboliths. The use of
MRI technology is very helpful in making the diagnosis of a hem-
angioma and the characteristic sharp mixed signal serpinginous
pattern is seen clearly on the T-1 weighted images. As with the
cutaneous hemangioma, the larger intramuscular hemangiomas in
children are not very disabling but can create symptoms of pain
caused by spontaneous hemorrhage into the lesion with minimal
blunt trauma. The pain symptoms can usually be treated with icing
down for the first 24 hours, followed by compressive dressings for
a period of two weeks, after which the patient returns to normal
activity. There may be a recurrence of these clinical symptoms once
or twice a year. Sometimes repeated hemorrhage into an intra-
muscular hemangioma can result in fibrotic contracture with
deformity of the adjacent joint that might require a surgical release
to correct the deformity. An example of this is equinous deformity
of the foot caused by a hemangioma of the gastroc muscle. In the
past, attempts have been made to eradicate these larger tumors in
muscle with embolization technique, attempting to occlude the feeder
vessels. This can lead to compartment syndrome, severe contractures
and loss of muscle strength that can be more severe a disability than
the original lesion. Wide surgical resection is extremely difficult
because of the poorly defined margin to the hemangioma and, as a
result, local recurrence is common, followed by intramuscular
hemorrhage and associated pain. In some cases with very large
hemangiomas, amputation is indicated when severe loss of function
occurs. It is extremely rare for a malignant conversion to occur
within a benign vascular dysplasia.
CLASSIC
Case #292
14 year female
hemangioma foot
AP x-ray showing
phleboliths
Lateral x-ray showing more phleboliths
Axial T-1 MRI
tumor
Axial T-2 MRI
tumor
Gross specimen with hemorrhagic cysts
Photomic
Case #293
36 year female
hemangioma hand
X-ray showing calcifying mass
AP and oblique views
Surgical removal
Photomic showing cavernous vascular spaces
Case #293.1
57 year female with
tender mass under
volar aspect of 3rd
MP joint for years
Hemagioma of hand
Axial T-1 prox phalanges T-2
Gad PD metacarpal heads
Cor T-1 T-2
Gad
Cor T-1 T-2
Gad
Case #293.2
52 year old female with
tender lump beneath 2nd
MP joint for years
Hemagioma hand
Cor T-1 T-2 FS
Gad
Axial T-1 T-2 FS
Gad
Gad
47 year old male with long
history intermittent painful
swelling palm of hand
Case #293.3 Tenosynovial Hemangioma Hand
Cor T-1 T-2
Axial T-1
Gad
Case #294
30 year female with hemangioma hand
Case #295
8 year female with
hemangioma distal arm
phlebolith
Lateral view
Coronal T-1 MRI Coronal T-2 MRI
Sagittal T-1 MRI Sagittal T-2 MRI
Axial T-1 MRI Axial T-2 MRI
Photomic showing large vascular spaces
bone
Case #295.1 Recurrent hemangioma
24 year female with recurrent hemangioma triceps
phleboliths
Coronal T-1 T-2
Sagittal T-1 T-2
Axial
T-1
T-2
Gad
Case #295.2
16 year female with tender mass in posterior arm for years
Cor CT Axial CT
Hemagioma triceps m
Cor T-1 T-2 Gad
Axial PD Gad
Sag PD Gad
Case #296
24 year female with hemangioma forearm with phleboliths
Case #297
6 year female
hemangioma forearm
phlebolith
Case #297.1
18 year old female with forearm mass for years
Cor T-1 Gad
Hemangioma forearm
Axial T-1
Axial Gad
Case #297.2
46 yr male with
tender soft mass
forearm for years
Hemangioma forearm
Cor T-1 T-2 Gad
Sag T-1 T-2 Gad
Axial T-1 T-2
Gad
Case #298
10 year female with a
hemangioma distal
leg and foot
Sagittal T-2 MRI
Axial T-2 MRI
Sagittal T-1 MRI foot
Sagittal T-2 MRI
Axial T-2 MRI
Case #298.1 Hemangioma Ankle Sag Gad
52 yr female with 30 year history of intermittent pain in ankle
Cor T-1 T-2 FS Gad
Axial T-1 T-2 FS
Gad
Surgical resection
Case #298.1
15 year male with tender
mass lateral side of forefoot
for many years
Hemangioma
Axial T-1
T-2
Sag T-1
T-2
Cor T-2
Case #1204
22 year male with
hemangioma anterior
compartment leg with
subadjacent cortical
hypertrophy of tibia
Axial gad
contrast MRI
Coronal T-1 MRI
Case #1204.1
31 year female with soft swelling in leg for many years
Cor Ct
Axial CT
Cor T-2 Sag Gad Sag Gad
Axial Gad Axial Gad
Case #1205
38 year female with
hemangioma forearm
with hypertrophic response
in subadjacent ulna
Bone scan
Axial PD MRI
bone hypertrophy
Axial gad contrast MRI
Sagittal T-2 MRI
Case #1206
31 year female with
hemangioma leg with
hypertrophic response
in adjacent fibula
Axial T-2 MRI
Coronal T-1 MRI
Case #1207
25 year female with hemangioma buttock area
tumor calcification
Coronal T-1 MRI
Sagittal T-2 MRI
Case #1207.1
65 year old female
with tender lump in
buttock for 1 year
Axial T-1 T-2
Gad
Hemangioma
buttock
Cor T-2
Sag T-2
CT scan
Pet scan
Case #1208
28 year female with hemangioma gastroc muscle
tumor calcification
Sagittal T-1 MRI
Axial T-1 MRI
Case #1208.1
Axial CT scan Sag
43 year old female with tender lump in medial gastroc for years
Axial T-2 Gad
Sag T-1 Gad
Case #1208.2 Sag T-1 PD FS Gad
16 year female with intermittent pain and swelling in calf for years
second to hemagioma of the gastroc muscle
Axial T-1 T-2
Gad
Case #1209
17 year male with
hemangioma in
quadriceps muscle
Axial T-2 MRI
Case #1210
14 year female with
hemangioma hind foot
Axial T-2 MRI
Case #1211
67 year female with
synovial hemangioma
hip joint with secondary
erosion of femoral
head and neck
Synovial biopsy showing numerous vascular spaces
4 year male with painless mass below the patella 1 yr
Case #1211.1 Synovial hemangioma knee
Sagittal T-1 Sagittal T-2
Axial T-1 Axial T-2 Axial Gad
Case #1211.2
15 year male with knee pain for 6 months
Synovial hemagioma knee
Coronal T-1 Coronal T-2
Axial T-2
Surgical exposure at time of excisional biopsy
Case #1211.3
68 year old female with soft mass medial knee for years
Synovial hemangioma knee
Cor T-1 T-2
Gad
Sag PD Gad
Axial T-2 Gad
Hemangiomatosis
CLASSIC
Case #299
Stillborn with extensive
hemangiomatosis
Upper body showing disappearing bones
Lower half of body
Lower extremity with
disappearing bones
in hemangiomatosis
Case #300
25 year female
hemangiomatosis
upper extremity with
disappearing bones
phleboliths
Case #1212
34 year female with hemagiomatosis forearm
phleboliths
Case #1212.1
39 year male with extensive hemangiomatosis thigh
Coronal T-1
MRI
arteriogram
Lymphangiomas
Lymphangioma
The Lymphangioma, like the hemangioma, is a hamartomatous
dysplastic lesion of soft tissue that arises from the endothelial tube.
Instead of being filled with blood like in the hemangioma, the lymph-
angioma is filled with lymphatic fluid, but otherwise it has a very
similar histological appearance. 90% of these lesions will occur
before the age of two years. There is no sex predominance and the
most common locations are the head and neck, axilla, inguinal area
and, in some cases, the abdominal viscera including the liver and
spleen. Lymphangiomas can be classified as either the capillary type
or simplex type which are considered cutaneous lesions. Larger,
deeper lesions are usually cavernous or cystic in nature and referred
to as cystic hygromas.
CLASSIC
Case #301
23 year female
lymphangioma forearm
and hand with
thumb gigantism
Surgical specimen from forearm
Photomic showing lymphatic channels
Case #302
7 month male
lymphangioma
elbow
Coronal T-1 MRI
Axial T-2 MRI
Case #303
10 year female with lymphangioma forearm
Axial proton density MRI
fluid cyst
Axial T-2 MRI
Case #304 Axial T-1 MRI
21 year female with lymphangioma inguinal area
Axial T-1 MRI more distal
Axial T-1 MRI even more distal
Surgical specimen cut in path lab
Photomic with lymphatic channels
Case #304.1
Gad
8 yr old male with soft mass
over buttock for years with
intermittent clear serous fluid
drainage
Cor T-1 T-2
Lymphangioma Buttock
Axial T-1 Axial T-2
Axial Gad Sag T-2
Case #1213
46 year male with
lymphangioma arm
Axial PD MRI
Another T-2 MRI
showing 2 lesions
Coronal T-2 MRI
showing lymphangioma
next to cephalic vein
vein
Sagittal T-2 MRI
showing hygroma
next to brachial
vessels
vessels
Photomic of lymphangioma
Glomus Tumor
Glomus Tumor The glomus tumor and the hemangiopericytoma are vascular
tumors that arise from the hemangiopericyte which is a cell at the
periphery of the capillary vascular network whose normal function
is to regulate the flow of blood thru the capillary tube system. There-
fore, these are tumors that arise from cells outside the endothelial
tube where hemangiomas originate from endothelial cells. The
glomus tumor is a small and usually subcutaneous tumor measuring
less than 1 cm in diameter and represents 1.6% of all soft tissue
tumors. It occurs equally in men and women between the ages of
20 and 40 years. The most common location for the glomus tumor
is in the subungual area of a digit where it is readily visible,
exquisitely tender on palpation and has a reddish-purple color.
Subcutaneous glomus tumors that occur in the hand, wrist, forearm
and foot area are invisible to physical diagnosis and characteristically
present with localized lancinating pain that persists in the exact
location of origin until treated by minimal wide surgical resection.
CLASSIC Case #305
50 year male with glomus tumor thumb
AP x-ray
Surgical removal
Photomic showing hemangiopericytes
blood
Case #306
45 year female with glomus tumor web space hand
Case #307
Surgical exposue subcutaneous glomus tumor
forearm 45 year female
Hemangiopericytoma
Hemangiopericytoma
The hemangiopericytoma arises from the same hemangiopericytes
in the capillary system but is a larger tumor seen in more proximal
areas, usually a deep tumor in muscle bellies about the thigh or
retroperitoneal area of the pelvis. The smaller tumors are usually
benign but the larger, more aggressive pericytomas can be malignant
and therefore deserve more aggressive treatment with wide resection
followed by postoperative radiation therapy because of the chance of
local recurrence.
CLASSIC Case #308 Sagittal T-1 MRI
87 year female with hemangiopericytoma below groin
Another sagittal
T-1 MRI
Axial proton density MRI
Cut specimen in path lab
Photomic
Case #309 Coronal T-1 MRI
45 year male with hemangiopericytoma thigh
Axial T-1 MRI
Axial proton density MRI
Axial T-2 MRI
tumor
Case #310 Axial T-1 MRI
44 year female with hemgiopericytoma thigh
Axial T-2 MRI
tumor
Sagittal T-2 MRI
tumor
Case #311
58 year female
malignant hemangiopericytoma
arm
Coronal T-1 MRI
tumor
Coronal proton density MRI
tumor
Axial proton
density MRI
tumor
Kaposi’s Sarcoma
Kaposi’s Sarcoma
Kaposi’s sarcoma is considered to be the most common of all
soft tissue malignant vascular tumors and can be divided into the
chronic, lymphadenopathic, transplant associated type, and the
AIDS-related type. It is a cutaneous angiosarcoma seen just beneath
the skin, presenting with a characteristic purplish-blue appearance,
similar to a cutaneous hemangioma. It occurs most commonly in
men and is endemic in Central Africa where AIDS is very prevalent.
The most frequent location for the Kaposi’s sarcoma is in the foot
and ankle area. Microscopically, the tumor has an aggressive
vascular pattern but with rare mitoses. However, over a period of
years the tumor can develop into a high grade angiosarcoma or even
fibrosarcoma. The overall mortality runs between 10 and 20%. The
treatment usually consists of local radiation therapy or surgical
resection if the lesion is localized.
Case #312
75 year female with Kaposi’s sarcoma foot
Plantar view
Cut resected specimen
Photomic
Case #313
65 year male with Kaposi’s sarcoma foot
Photomic
Angiosarcoma
Angiosarcoma
The soft tissue angiosarcoma is an extremely rare soft tissue
tumor, accounting for less than 1% of all sarcomas. It is usually
a cutaneous lesion that affects males more often than females. It
can be deeply located, seen typically in the upper extremities
of women who have had chronic lymphedema following radical
breast surgery and radiation therapy. The high grade angiosarcoma
is not a very bloody tumor and does not have the typical vascular
spaces seen in benign vascular tumors or low grade intermediate
angiosarcomas. The prognosis for the high grade angiosarcoma is
very poor, especially for older people, and the treatment usually
consists of wide local resection and postoperative radiation
therapy.
CLASSIC Case #314 Sagittal proton density MRI
30 year male with high grade angiosarcoma heel
Coronal T-2 MRI
Sagittal proton density MRI
Metastasis to inguinal lymph node
Sagittal T-2 MRI of positive lymph node
Low power photomic
Higher power showing pleomorphic giant cells
around vascular spaces
Case #314.1
52 yr old male with
tender mass in proximal
anterior thigh area 3 mos
Angiosarcoma Thigh
Axial T-1 STIR
Cor STIR Sag STIR