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THE IMPORTANCE OF VITAMINS IN MALE AND FEMALE INFERTILITY

DR. SULEIMAN DABITHEAD OF ART AND GENETIC

DEPARTMENT AL KHALIDI MEDICAL CENTER

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Questions?

What vitamins are good for women to

become more fertile?What kinds of vitamins can men taketo increase fertility?

What can I take to increase spermmobility?

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Oxidative Stress and Infertility

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Counteracting All Factors of Oxidative Stress

Endogenous

MetabolismInflammation

InfectionsDiseases

Respiratory burstHypoxia-

reperfusionStress

Exogenous

SmokingPollutionRadiation

DrugsFood additives

InsecticidesPesticides

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Oxidative Stress Plays An Essential Role In Acceleration

Of ManyChronic Diseases

Atherosclerosis Alzheimer Liver disease

Chronic eye diseaseMale & female

infertility Threatened abortion

Immune system

disorders Diabetic nephropathy Diabetic neuropathy

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Counteracting All Factors of Oxidative Stress

Free Radicals(Oxidative Factors)

A molecule left with unpairedelectron circulating to get paired

from different cells known as a freeradical

Antioxidant(Donor Factor Protective

Factor)

A molecule which prevents orslows down oxidation by donating

electron to free radical while

staying stable

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*Ashok Agarwa l , PhD, HCLD and S a j a l G u p t a ,MD

Oxidative StressAffects Multiple Physiological Processes

Embryo Development And Pregnancy*Oocyte Maturation To Fertilization*

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Plasma membranes containlarge quantities of

polyunsaturated fatty acids

Cytoplasm contains lowconcentrations of thescavenging enzymes

Spermatozoa Are The Most Susceptible To ROS**

Due To

Oxidative StressIs A Common Pathology In Approximately

50%Of Infertile Men*

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Damage to sperms DNA resultsin infertility

(Teratozoospermia)

Damage to sperm membrane

decrease sperms motility(Athenozoospermia)

Higher Levels Of ROS & Lower Levels OfProtective Antioxidants Within Their Semen

Leading To

Rather Than All Men,Those Suffering From

InfertilityHas Significantly*

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Free RadicalsWhen DNA is attacked, it can be alsoaltered by free radicals.Ovum and sperm cells can be affectedby free radical damage so are thereproductive organ and glands thatproduce reproductive hormones

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DNA Fragmentation

Damaged DNA can causemiscarriages or birth defects anddevelopmental problems for the futurechild.

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Antioxidants for male

subfertility (Review)Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ

This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration andpublished in The Cochrane Library, 2011, Issue 11

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[Intervention Review]Antioxidants for male

subfertility A B S T R A C TBackgroundBetween 30% to 80% of male subfertility cases are considered to

be due to the damaging effects of oxidative stress on sperm. Oralsupplementation with antioxidants may improve sperm quality byreducing oxidative stress.

ObjectivesThis Cochrane review aimed to evaluate the effect of oral

supplementation with antioxidants for male partners of couples

undergoing assisted reproduction techniques (ART).Search strategyThis Review searched the Cochrane Menstrual Disorders and

Subfertility Group Register, CENTRAL (The Cochrane Library),MEDLINE,

EMBASE, CINAHL, Psyc INFO and AMED databases (from their inception until February 2010), trial registers, sources of un ublished literature, reference lists and the asked ex erts in

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[Intervention Review]Antioxidants for male

subfertility Selection criteriaThis Review included 34 randomisedcontrolled trials with 2876 couples intotal comparing any type or dose of antioxidant supplement (single or combined) taken by the male partner of a couple seeking fertility assistancewith placebo, no treatment or another antioxidant.

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[Intervention Review]Antioxidants for male

subfertility Main results

Live birth : Men taking oral antioxidants had an associatedstatistically significant increase in live birth rate (pooled oddsratio (OR) 4.85, 95% CI 1.92 to 12.24; P = 0.0008 , I2 = 0%)when compared with the men taking the control.Pregnancy rate : there were 96 pregnancies in 15 trials including 964 couples. Antioxidant use was associated with a statistically significant increased pregnancy rate comparedto control (pooled OR 4.18, 95% CI 2.65 to 6.59; P