Visit www.massgeneral.org/kraftsymposium to view agenda and register.

Questions? Contact: Sophia Sid | ssid@mgh.harvard.edu | (617) 726-6015

1:00 pm Welcome and opening remarks Daniel A. Haber, MD, PhD Director, Mass General Cancer Center

Introductions Nir Hacohen, PhD Director, Center for Cancer Immunology Mass General Cancer Center

1:10 pm “Vaccine boosting natural and synthetic T cells for cancer immunotherapy” Darrell J. Irvine, PhD Professor of Materials Science & Engineering and Biological Engineering Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Ragon Institute of MGH, MIT, and Harvard Investigator, Howard Hughes Medical Institute

1:40 pm “CAR T cell deliveries for glioblastoma” Marcela V. Maus, MD, PhD Assistant Professor of Medicine Director, Cellular Immunotherapy Program Massachusetts General Hospital Cancer Center and Harvard Medical School Associate Member, Broad Institute of Harvard and MIT

2:10 pm Break

2:30 pm “Pumping the brakes: Understanding T cell function and dysfunction through the lens of graft versus host disease” Leslie S. Kean, MD, PhD Robert A. Stranahan Professor of Pediatrics Harvard Medical School Director, Pediatric Stem Cell Transplantation Program, Boston Children’s Hospital and Dana-Farber Cancer Institute

3:00 pm “Redirecting immunity against cancer using antibody circuits” Mark Cobbold, MD, PhD Associate Professor of Medicine Center for Cancer Immunology, Massachusetts General Hospital Cancer Center and Harvard Medical School Associate Member, Broad Institute of Harvard and MIT

3:30 pm Break

3:50 pm Keynote Speaker Introduction & Prize Presentation Daniel A. Haber, MD, PhD Director, Mass General Cancer Center

4:00 pm Keynote Address

“Car T cell therapy for cancer” Carl June, MD Richard W. Vague Professor in Immunotherapy Director, Center for Cellular Immunotherapies Perelman School of Medicine University of Pennsylvania

Agenda

SymposiumJonathan Kraft Prize for Excellence in Cancer ResearchPresented by the Massachusetts General Hospital Cancer Center