Virtual Tumor Bank (VTB) System
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Transcript of Virtual Tumor Bank (VTB) System
EORTC
EORTC Virtual Tumor Bank (VTB)
EORTC
Tumor Bank Steering Committee, which is composed of representatives of the EORTC Pathology Group and EORTC Data Center:
Wolter Oosterhuis, EORTC Tumor Bank, chairman
Alain Spatz, EORTC Pathology group, chairman
King Lam, EORTC Pathology sub-committee group for Telematics, chairman
Peter Riegman, pathologist and assistant project leader of the TuBaFrost Project, Erasmus Medical Center, Rotterdam
Ivana Teodorovic, EORTC Tumor Bank Coordinator, EORTC Data Center
Martin Isabelle, EORTC Tumor Bank Administrator (TBA), EORTC Data Center EORTC IT unit (Pascal Ruyskart, Yves Dohogne and Eric Decossaux)
EORTC Legal Advisor Pilot phase project sponsored by Parthenon Trust (Sept 2000- Sept 2003)
EORTC Tumor BankEORTC Tumor Bank
EORTC
EORTC Tumor Bank - AimsEORTC Tumor Bank - Aims
•To standardize and support histology review across To standardize and support histology review across EORTC trials (quality of research) EORTC trials (quality of research)•Create tumor bankCreate tumor bank
–Real tumor bank (centralized storage of paraffin embedded tissue blocks and glass slides [stained/unstained] at the EORTC Data Center)
–Virtual tumor bank (information and histological images on centralized and decentralized stored material)
–Legal issues–Access and use
•Facilitate translational research (by making Facilitate translational research (by making biological material available to scientists)biological material available to scientists)
EORTC
Histology review
Tumor banking Translational research
Virtualtumour bank
and real tumour bank
EORTC
Glass SlidesParaffin Embedded Tissue Blocks
Real Tumor Bank (EORTC Data Center)
EORTC
Material and Data Flowchart during histology review
EORTC
Support for Translational Research within EORTC protocols
EORTC
Patient information Sheet/Informed consent (PIS/IC)
in case of optional research on biological material separate documents for clinical PIS/IC and the one related to translational research
in case of mandatory research on biological material within a clinical trial, only one PIS/IC covering both aspects
explanation about research on biological material must be clear and transparent and should include:
- information about possibility to reveal any kind of hereditary nature of disease
- protection of patient rights and identity- benefits for research- voluntary aspects
- in case of optional research- in using material for future cancer research- on sending the material to a third party
- agreement for an additional tissue sampling- explanation about intellectual property rights
EORTC
Virtual Tumor Bank (VTB) - Goals
Design and construction of a pathology database for pathology and material data and a link to the EORTC clinical database
Construction of a website (Virtual Tumor Bank) to allow users to access patient's pathology, clinical and material (including images) data online and allow online pathology review to take place.
Construction of an online search engine to allow researchers to search for tissue material, view tissue information (including images) and check on tissue availability for their research projects.
EORTC
Virtual slides can be produced from the glass slides collected and stored with the tissue records within the VTB. This will support histology review and provide further assistance to researchers.
EORTC
Panel Review (if required)
Panel Member (PM)
Panel Chairperson (PC)
Panel Member (PM) Panel Member (PM)
VTB System
VISTADATABASE
VTBDATABASE
Virtual Tumor Bank
EORTC
Current Tumor Bank Project Current Tumor Bank Project supported trials/groupssupported trials/groups
GU Group (30993 + 30994) Gynecological Cancer Group (55994 and
55012) GI Group STBSG Group (62005)
EORTC
Future hopes and goals for the EORTC Tumor Bank and TuBaFrost
Short Term: use the VTB for central access to decentralised collections of frozen tissues in further EORTC-
affiliated institutions prospectively collect paraffin blocks of all patients entered in an EORTC trials make the existing collections of material available to investigators for translational research engage EORTC-affiliated OECI institutions in building up collections of frozen tissues of patients
entered in EORTC trials submit a follow up project for TuBaFrost in the 6FP in collaboration with the OECI select one Pathology Lab to do the lab work for the Tumor Bank at the DC; the lab of Erasmus MC
would be a good candidate in view of its current role in the VTB and the TuBaFrost Project set up a Charitable Trust in collaboration with the OECI
Long Term: purchase a machine to make tissue micro-arrays at the DC and make virtual slides of tissue micro-
arrays and of the experimental results obtained with them create a small lab at the DC for cutting paraffin blocks and staining slides with H and E make tissues available to the research community and the private sector through the Charitable
Trust, on a not-for-profit basis
EORTC
Screenshots of the Virtual Tumor Bank (VTB) System
EORTC
EORTC
EORTC
EORTC
EORTC
EORTC
EORTC
EORTC
EORTC Tumor Bank Website:
www.eortc.be/vtb/tumorbank