Veterans Aging Veterans Aging Cohort Study (VACS)Cohort Study (VACS)

Required:Required:

Optional based on other project funding: Optional based on other project funding:

Now have support through August 2016 for a total of 20 years of follow up in Virtual Cohort and 16 years for VACS 8

VACS Cohort and SubstudiesVACS Cohort and Substudies

VC limited to patients in 2003 or later. Includes adjudicated MI from IHD Queri

Virtual Cohort(VC) comprised of national data. Elements include demographics, diagnostic and procedure codes, labs, pharmacy, vital signs…

VACS9 is the 9 site consented patient study with richer data. Includes surveys, adjudicated outcomes for cancer, mi, liver disease, site downloaded data

Includes Ddimer, IL6, sCD14

3 VACS sites only. Includes GXT, CT and echo data

Virtual Cohort (VC)Virtual Cohort (VC) SUBJECTS: 47,805 HIV infected; 99,061 uninfectedSUBJECTS: 47,805 HIV infected; 99,061 uninfected

All individuals with HIV diagnosesAll individuals with HIV diagnoses Age, race/ethnicity, region 2:1 matched controlsAge, race/ethnicity, region 2:1 matched controls Last updated: September 2014Last updated: September 2014 Next update: Currently in progressNext update: Currently in progress

SITES: All VA sitesSITES: All VA sites

BASELINE: 1998 (15 years of follow up)BASELINE: 1998 (15 years of follow up) HIV infected veterans at initiation of HIV careHIV infected veterans at initiation of HIV care Controls selected and followed in same calendar yearControls selected and followed in same calendar year

VACS 9VACS 9 CURRENT DATA SOURCES (all VC sources plus) CURRENT DATA SOURCES (all VC sources plus)

All VA Electronic medical records All VA Electronic medical records including text fieldsincluding text fields Sentinel event records (MI) requested outside VASentinel event records (MI) requested outside VA DNA and tissue bank (subset of 2,300 patients)DNA and tissue bank (subset of 2,300 patients) Self completed surveys (health behaviors, quality of life, Self completed surveys (health behaviors, quality of life,

symptoms, outside utilization, etc.) every 12-18 monthssymptoms, outside utilization, etc.) every 12-18 months

SUBJECTS: 3,790 HIV infected; 3,962 uninfectedSUBJECTS: 3,790 HIV infected; 3,962 uninfected Group matched: age, race/ethnicity, and siteGroup matched: age, race/ethnicity, and site Last updated October 16, 2013Last updated October 16, 2013

SITESSITES:: AtlantaAtlanta11, Bronx, Bronx11, Houston, Houston11, Los Angeles, Los Angeles11, New York, New York11, , BaltimoreBaltimore22, Washington DC, Washington DC22, Pittsburgh, Pittsburgh33, Dallas, Dallas44, Nashville, Nashville55 **** 1. 2002-present, 2. 2003-present, 3. 2003-present, 4. 2012-present, 5. 2015-present1. 2002-present, 2. 2003-present, 3. 2003-present, 4. 2012-present, 5. 2015-present

BASELINE: 2002 (11 years)BASELINE: 2002 (11 years)

National VACS/COMpAAAS Project Team 2014

COMpAAAS

AcknowledgementsAcknowledgements Consortium PI : AC Justice*

Scientific Collaborator (NIAAA): K Bryant

Affiliated PIs: S Braithwaite, K Crothers*, R Dubrow, DA Fiellin*, M Freiberg*, V LoRe*, K Kraemer

Participating VA Medical Centers: Atlanta (V Marconi*), Baltimore (M Sajadi, R Titanji), Bronx (S Brown, Y Ponomarenko), Dallas (R Bedimo*), Houston (M Rodriguez-Barradas, N Masozera), Los Angeles (M Goetz, D Leaf), Manhattan-Brooklyn (M Simberkoff, D Blumenthal, H Leaf, J Leung), Pittsburgh (A Butt, K Kraemer, E Hoffman), and Washington DC (C Gibert, R Peck)

Core and Workgroup Chairs: B Agan, W Becker, C Brandt, J Edelman, N Gandhi, B Gulanski, K McGinnis, KA Oursler, L Park, C Rinaldo, K Sigel, J Tate, E Wang, F P Wilson, J Womack

Staff: H Bathulapalli, T Bohan, J Ciarleglio, A Consorte, L Erickson, S Felter, C Frank, K Gordon, J Huston, F Kidwai-Khan, G Koerbel, F Levin, S Shahrir, M Skanderson

Major Collaborators: VA Public Health Strategic Healthcare Group, VA Pharmacy Benefits Management, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Yale Center for Interdisciplinary Research on AIDS (CIRA), Center for Health Equity Research and Promotion (CHERP), ART-CC, NA-ACCORD, HIV-Causal

Cross Cohort Collaborators: Richard Moore (NA-ACCORD), Jonathan Sterne (ART-CC), Brian Agan (DoD), Miguel Hernan (HIV-Causal)

Major Funding by: National Institutes of Health: AHRQ (R01-HS018372), NIAAA (U24-AA020794, U01-AA020790, U01-AA020795, U01-AA020799, U24-AA022001, U24 AA022007, R01-AA023733, R01AA022886, U10 AA013566-completed), NHLBI (R01-HL125032, RO1-HL126555, R01-HL095136-completed, R01-HL090342-completed) , NIAID (U01-A1069918), NIDA (R01DA035616, R03DA031592), NCI (R01 CA173754) and the Veterans Health Administration Office of Research and Development (VA REA 08-266, VA IRR Merit Award) and Office of Academic Affiliations (Medical Informatics Fellowship)*Indicates individual is also the Chair of a Core or Workgroup

AcknowledgementsAcknowledgementsContinuedContinued

Other Notable Funding:Other Notable Funding: Career Development Awards: Career Development Awards: Veterans Health Administration: VISN 1 Veterans Health Administration: VISN 1 CDA (V1CDA2012-20), HSR&D CDA-2 (08-276); National Institutes of Health: NINR CDA (V1CDA2012-20), HSR&D CDA-2 (08-276); National Institutes of Health: NINR (1K01R013437), NCRR/NCATS (5UL1RR024139), NIDA (1K12DA033312-01A1, (1K01R013437), NCRR/NCATS (5UL1RR024139), NIDA (1K12DA033312-01A1, 8UL1TR000142, 1R03DA031592)8UL1TR000142, 1R03DA031592)

COMpAAAS/Veterans Aging Cohort Study, a CHAART Cooperative Agreement, COMpAAAS/Veterans Aging Cohort Study, a CHAART Cooperative Agreement, supported by the National Institutes of Health: National Institute on Alcohol Abuse supported by the National Institutes of Health: National Institute on Alcohol Abuse and Alcoholism (U24-AA020794, U01-AA020790, U01-AA020795, U01-AA020799; and Alcoholism (U24-AA020794, U01-AA020790, U01-AA020795, U01-AA020799; U10 AA013566-completed) and in kind by the US Department of Veterans Affairs.  U10 AA013566-completed) and in kind by the US Department of Veterans Affairs.   In In addition to grant support from NIAAA, we gratefully acknowledge the scientific addition to grant support from NIAAA, we gratefully acknowledge the scientific contributions of Dr. Kendall Bryant, our scientific collaborator.contributions of Dr. Kendall Bryant, our scientific collaborator.

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