Cell junctions

Epithelial Cell Junction Types

Cell adhesion molecules

EM desmosomes; Arrows point to the density which typically appears in the intercellular space. The cell membranes of the two

neighboring cells are interlocked in a very complex interdigitation here. You can follow the undulating course of the intercellular space.

(A) EM; A DESMOSOME JOINING TWO CELLS in the epidermis(B) Schematic drawing of A DESMOSOME

Tzanck smear of PVshowing abundant acantholytic cells. (Giemsa stain, 10× )

Tzanck cells in PV. Note the perinuclear halo visible in the marked cell. (Giemsa stain, 40× )

Normal skin

Linear band of IgA at dermo-epidermal junction

Direct Immunofluorescence

Indirect Immunofluorescence