VERTICAL vs. HORIZONTAL VERTICAL vs. HORIZONTAL LAMINAR AIRFLOW WORKBENCH LAMINAR AIRFLOW WORKBENCH

(LAFW)(LAFW)

OBJECTIVES OBJECTIVES

TO UNDERSTAND WHY LAFW ARE USED TO UNDERSTAND WHY LAFW ARE USED IN STERILE COMPOUNDING.IN STERILE COMPOUNDING.

TO BE ABLE TO DIFFERENTIATE TO BE ABLE TO DIFFERENTIATE BETWEEN A HORIZONTAL AND VERTICAL BETWEEN A HORIZONTAL AND VERTICAL LAFW AND HOW TO WORK WITHIN LAFW AND HOW TO WORK WITHIN THEM.THEM.

WHY DO WE USE LAFW?WHY DO WE USE LAFW?

THE LAMINAR AIRFLOW WORKBENCH THE LAMINAR AIRFLOW WORKBENCH (LAFW) PROVIDES A SAFE WORKING (LAFW) PROVIDES A SAFE WORKING ENVIROMENT FOR THE MANUFACTURE ENVIROMENT FOR THE MANUFACTURE OF STERILE PRODUCTS. OF STERILE PRODUCTS. THEY SERVE TO MINIMIZE/ELIMINATE THEY SERVE TO MINIMIZE/ELIMINATE THE INTRODUCTION OF PARTICULATE, THE INTRODUCTION OF PARTICULATE, MICROORGAMISMS, AND OTHER MICROORGAMISMS, AND OTHER CONTAMINANTS.CONTAMINANTS.

HORIZONTAL LAFWHORIZONTAL LAFW

HORIZONTAL LAFWHORIZONTAL LAFW

AIR DRAWN IN IS CYCLED THROUGH PREAIR DRAWN IN IS CYCLED THROUGH PRE--FILTER. INTENDED TO ELIMINATE COARSE FILTER. INTENDED TO ELIMINATE COARSE PARTICLES/PARTICULATES. PARTICLES/PARTICULATES. AIRFLOW THEN PROCEEDS THOUGH THE HEPA AIRFLOW THEN PROCEEDS THOUGH THE HEPA FILTER AND IS BLOWN HORIZONTALLY FILTER AND IS BLOWN HORIZONTALLY ACROSS THE WORK SURFACE.ACROSS THE WORK SURFACE.HEPA FILTER REMOVES 99.97% OF PARTICLES HEPA FILTER REMOVES 99.97% OF PARTICLES THAT ARE 0.3 MIRCRONS OR LARGER.THAT ARE 0.3 MIRCRONS OR LARGER.

HORIZONTAL LAFW AIRFLOWHORIZONTAL LAFW AIRFLOW

PRODUCT PLACEMENTPRODUCT PLACEMENT HORIZONTAL LAFWHORIZONTAL LAFW

PRODUCT MUST BE 15CM FROM THE SIDES AND THE FRONT OF PRODUCT MUST BE 15CM FROM THE SIDES AND THE FRONT OF THE LAFW, AND AT LEAST 5CM AWAY FROM THE BACK OF THE THE LAFW, AND AT LEAST 5CM AWAY FROM THE BACK OF THE LAFW/HEPA FILTER.LAFW/HEPA FILTER.

PRODUCTS HAVING CRITICAL SITES MUST REMAIN IN THE PRODUCTS HAVING CRITICAL SITES MUST REMAIN IN THE AIRFLOW AND NOT HAVE THEIR AIRFLOW OBSTRUCTED. NO AIRFLOW AND NOT HAVE THEIR AIRFLOW OBSTRUCTED. NO PRODUCT DIRECTLY BEHIND OTHER PRODUCT, SUPPLIES, OR PRODUCT DIRECTLY BEHIND OTHER PRODUCT, SUPPLIES, OR DEVICES.DEVICES.

THE WORKER SHOULD AVOID ANY RAPID OR SWEEPING THE WORKER SHOULD AVOID ANY RAPID OR SWEEPING MOVEMENTS WHILE IN THE HOOD. MAKING SURE NOT TO PLACE MOVEMENTS WHILE IN THE HOOD. MAKING SURE NOT TO PLACE HANDS OR PRODUCT IN FRONT OF OTHER PRODUCT.HANDS OR PRODUCT IN FRONT OF OTHER PRODUCT.

LAFW SHOULD NOT BE OVERLOADED.LAFW SHOULD NOT BE OVERLOADED.

CORRECT INCORRECTCORRECT INCORRECT PLACEMENT PLACEMENTPLACEMENT PLACEMENT

HORIZONTAL LAFWHORIZONTAL LAFW

HORIZONTAL LAFH ARE LESS EXPENSIVE HORIZONTAL LAFH ARE LESS EXPENSIVE THAN VERTICAL LAFH.THAN VERTICAL LAFH.THEY ARE SUITABLE FOR COMPOUNDING THEY ARE SUITABLE FOR COMPOUNDING MOST STERILE PRODUCTS.MOST STERILE PRODUCTS.ABSOLUTELY ABSOLUTELY NO CHEMOTHERAPY/ NO CHEMOTHERAPY/ HAZARDOUSHAZARDOUS DRUGS ARE TO BE DRUGS ARE TO BE COMPOUNDED IN COMPOUNDED IN HLAFHHLAFH..

VERTICAL LAFWVERTICAL LAFW

VERTICAL LAFWVERTICAL LAFW

AIR DRAWN IN IS CYCLED THROUGH PREAIR DRAWN IN IS CYCLED THROUGH PRE--FILTER. INTENDED TO ELIMINATE COARSE FILTER. INTENDED TO ELIMINATE COARSE PARTICLES/PARTICULATES. PARTICLES/PARTICULATES. AIRFLOW THEN PROCEEDS THOUGH THE HEPA AIRFLOW THEN PROCEEDS THOUGH THE HEPA FILTER AND IS BLOWN VERTICALLY ON TO THE FILTER AND IS BLOWN VERTICALLY ON TO THE WORK SURFACE. SOME AIRFLOW IS RECYCLED WORK SURFACE. SOME AIRFLOW IS RECYCLED INTO THE LAFW WHILE THE REST IS INTO THE LAFW WHILE THE REST IS EXHAUSTED EXTERNALLY.EXHAUSTED EXTERNALLY.HEPA FILTER REMOVES 99.97% OF PARTICLES HEPA FILTER REMOVES 99.97% OF PARTICLES THAT ARE 0.3 MIRCRONS OR LARGER.THAT ARE 0.3 MIRCRONS OR LARGER.

VERTICAL LAFW AIRFLOWVERTICAL LAFW AIRFLOW

PRODUCT PLACEMENTPRODUCT PLACEMENT VERTICAL LAFWVERTICAL LAFW

PRODUCT MUST BE 15CM FROM THE SIDES AND THE FRONT OF PRODUCT MUST BE 15CM FROM THE SIDES AND THE FRONT OF THE GRATE, AND AT LEAST 5CM AWAY FROM THE BACK OF THE THE GRATE, AND AT LEAST 5CM AWAY FROM THE BACK OF THE LAFH.LAFH.

PRODUCTS HAVING CRITICAL SITES MUST REMAIN IN THE PRODUCTS HAVING CRITICAL SITES MUST REMAIN IN THE AIRFLOW AND MUST NOT HAVE THEIR AIRFLOW OBSTRUCTED. AIRFLOW AND MUST NOT HAVE THEIR AIRFLOW OBSTRUCTED. NO PRODUCTS/SUPPLIES DIRECTLY ABOVE OTHER PRODUCTS, NO PRODUCTS/SUPPLIES DIRECTLY ABOVE OTHER PRODUCTS, SUPPLIES, OR DEVICES.SUPPLIES, OR DEVICES.

THE WORKER SHOULD AVOID ANY RAPID OR SWEEPING THE WORKER SHOULD AVOID ANY RAPID OR SWEEPING MOVEMENTS WHILE IN THE HOOD. MAKING CERTAIN NOT TO MOVEMENTS WHILE IN THE HOOD. MAKING CERTAIN NOT TO PLACE HANDS OR SUPPLIES OVER PRODUCT.PLACE HANDS OR SUPPLIES OVER PRODUCT.

HOOD SHOULD NOT BE OVERLOADED.HOOD SHOULD NOT BE OVERLOADED.

CORRECT INCORRECTCORRECT INCORRECT PLACEMENT PLACEMENT PLACEMENTPLACEMENT

VERTICAL LAFW (BIOLOGICAL VERTICAL LAFW (BIOLOGICAL SAFETY CABINETS)SAFETY CABINETS)

VERTICAL LAFW ARE MORE EXPENSIVE VERTICAL LAFW ARE MORE EXPENSIVE THAN HORIZONTAL LAFH DUE TO THAN HORIZONTAL LAFH DUE TO EXTERIOR VENTING. EXTERIOR VENTING. THEY ARE SUITABLE FOR COMPOUNDING THEY ARE SUITABLE FOR COMPOUNDING ALL STERILE PRODUCTS.ALL STERILE PRODUCTS.THEY ARE THE ONLY LAFW SUITABLE TO THEY ARE THE ONLY LAFW SUITABLE TO COMPOUND CHEMOTHERAPY AND OTHER COMPOUND CHEMOTHERAPY AND OTHER HAZARDOUS PRODUCTS IN.HAZARDOUS PRODUCTS IN.

DIFFERENCES ? ? ?DIFFERENCES ? ? ?

NOT MUCH DIFFERENCE IN FUNCTIONALITY OF THE NOT MUCH DIFFERENCE IN FUNCTIONALITY OF THE LAFW. HEPA FILTERED AIR PROVIDES A STERILE LAFW. HEPA FILTERED AIR PROVIDES A STERILE ENVIROMENT FOR THE SAFE COMPOUNDING OF ENVIROMENT FOR THE SAFE COMPOUNDING OF DRUGS.DRUGS.

THE DIRECTION OF THE AIRFLOW FUNDEMENTALLY THE DIRECTION OF THE AIRFLOW FUNDEMENTALLY CHANGES HOW SOMEONE WORKS WITHIN THE LAFW.CHANGES HOW SOMEONE WORKS WITHIN THE LAFW.

WHILE THE HORIZONAL IS LESS EXPENSIVE, THE WHILE THE HORIZONAL IS LESS EXPENSIVE, THE VERTICAL REMAINS THE SAFEST MEANS FOR ALL VERTICAL REMAINS THE SAFEST MEANS FOR ALL DRUGS TO BE HANDLED WITHIN IT.DRUGS TO BE HANDLED WITHIN IT.

QUESTIONS ? ? ?QUESTIONS ? ? ?

CITATIONSCITATIONS

Retrieved June 9, 2011 from Retrieved June 9, 2011 from http://www.globalrph.com/aseptic.htmhttp://www.globalrph.com/aseptic.htmRetrieved June 9, 2011 from Retrieved June 9, 2011 from http://www.ashp.org/DocLibrary/Bookstore/P2081/SampleChapterP208http://www.ashp.org/DocLibrary/Bookstore/P2081/SampleChapterP2081.aspx1.aspxBuchanan E. C., & Schneider P. J. (2004), Buchanan E. C., & Schneider P. J. (2004), Compounding Sterile Preparations Second Compounding Sterile Preparations Second EditionEdition, , ASHP,LtdASHP,Ltd. Pp. 28. Pp. 28--29.29.