Ven t ilation-perfusion mismatch in COPD with or …...ange of TI (50, itchover from m s were...
1
Vent 1 Im Univer INTRO (COPD Recen The ai relatio METH mappi echo s monito corona V/Q m breath the M calcul LAA% RESU in whi structu V/Q m and so entire in a na broade subgro increa histog is no s In add three and IQ signifi signifi DISC presen increa includ CONC emphy OE-M betwe from d option REFE p.2516 ACKN tilation-perfus Weijuan Zhang 1,2 maging Sciences, S rsity of Manchester C ODUCTION X-r D), while dynam ntly a physiologi im of this study onship between C HODS Dynamic ing was perform sequence (IR-HA or the change in al slice was acqu maps [1,2]. Othe hing, no respirato MRI image was s ated to denote %<2.5%--non-em ULTS As can be ich the areas wi ure. However, in maps become het ome areas of inc lung can also be arrow range with er with longer t oups, the V/Q m ased inter quarti gram) in COPD s significant differ dition, median l subgroups. Figu QR-V/Q in em icant correlation icant correlation USSION COPD nt. Within the asing emphysem ding airway block CLUSION Con ysematous and n MRI estimated V en these two CO dynamic OE-MR n in the assessme ERENCES 1) N 6. 2) Hubbard, NOWLEDGEM sion mismatch , Penny L Hubbard School of Cancer & r , Manchester, Uni Chamwood, United ray computed tom mic oxygen-enha cal model has be is: 1) to compar CT measured em c OE-MRI and m med while subjec ASTE) with a r n T 1 during gas sw uired. All image er parameters we ory or cardiac tr selected for eac the fraction of mphysema type ( seen in figure1, thout enhancem n the COPD lun terogeneous with creased V/Q (or e illustrated by h h a sharp peak, w tails. Although t maps and histogra ile range of log subjects when c rence between th log 10 V/Q was n ure3 shows a si mphysematous C n in non-emph n between median D has regional V slice, V/Q dist a, while in non- kage and inflam nsiderably heter non-emphysema V/Q heterogenei OPD subtypes. RI using a non-io ent of COPD. Naish, J.& Parke P, et al. Proc MENT This stud h in COPD wi d 1,2 , Eva Bondesso & Enabling Scienc ited Kingdom, 3 Sem d Kingdom, 6 Unive mography (CT) anced (OE-) MRI een proposed to e the V/Q maps mphysema and O multislice CT we cts breathed me range of TI (50, witchover from m es were registere ere: TR/TE 5500 riggering. Quant h subject. The p emphysema. A (8 patients), LAA a healthy lung s ment (in dark blu ng, whether or h some areas of range and red). histograms. In th while in the COP the LAA% are q ams look simila g 10 V/Q (IQR-V/ ompared with h he COPD groups not significantly gnificant positiv COPD (r=0.449, hysematous COP n log 10 V/Q and V/Q mismatch tribution becom emphysematous mmation, maybe r rogeneous V/Q atous COPD. Ho ity and CT me The added phys onising source o r, G. Proc 18 th 18 th Intl Soc M dy was funded by ith or without on 3 , Lars Wigström ces, The University mcon Drug Develo ersity Hospital of S is powerful in e I enables assessm extract pulmona in COPD patien OE-MRI measure ere carried out o dical air (21% O 300, 1100, 200 medical air to 10 ed to the end ex 0 ms/3 ms, 68 p titative CT: Mul proportion of lu According to the A%≥2.5%--emp shows a homoge ue) seem to corre not emphysema decreased V/Q ( The distribution he healthy lung, PD lung, the hist quite different f r. Figure2 show /Q, denoting th ealthy subjects. s with and witho y different betw ve correlation b p=0.017), whi PD. In addition LAA% in either whether or not mes more heter s COPD, other fa responsible for V distribution pr owever, the corr easured emphys siological inform of contrast make Intl Soc Mag R Mag Reson Med y AstraZeneca. emphysema: m 4 , Simon S Young y of Manchester, M opment Consulting South Manchester estimating the st ment of regional ary ventilation/p nts with or witho ed ventilation-pe on 24 COPD pat O 2 ) using an inv 00 and 5000 ms 00% O 2 using th xpiration position phase-encoding s tislice CT was p ung area with an e 2D LAA%, C physema type (16 eneous V/Q map espond to vessel a is present, the (green and blue) n of V/Q in the V/Q distributes togram becomes for the 2 COPD s a significantly e width of the However there out emphysema. een any of the etween LAA% ile there is no n, there is no r COPD group. emphysema is ogeneous with actors, possibly V/Q change. esents in both elation between sema does vary mation available es it an attractive eson Med 2010; d 2010; p.2515 Fig1: a, b) lo healthy subjec log 10 V/Q map patient with LAA%=0.53% log 10 V/Q histo (62yrs, FEV 1 areas in LAA% comparison o g 5 , David Singh 6 , G Manchester, United g, Lund, Sweden, 4 r Foundation Trust tructural abnorm l oxygen deliver perfusion (V/Q) out emphysema i erfusion imbalan tients and 12 hea version-recovery s). This was foll he same HASTE n and fitted pixe steps to reconstr performed in CO n attenuation va COPD subjects 6 patients). p, l e ), e s s D y n y e e ; . a c d f g h p<0.0 Healthy LAA% og 10 V/Q map an ct (58yrs, FEV 1 p and log 10 V/Q hout emphysem %); f, g, h) LA ogram of a male %=67%, LAA% % maps are show of functional O Geoffrey JM Parke d Kingdom, 2 The B 4 AstraZeneca R&D t, Manchester, Uni malities of chron ry and uptake by maps directly fr identified in 2D nce in COPD pat althy volunteers y half Fourier a lowed by a T 1 -w E sequence but w el-by-pixel by a ruct a 128 x 128 OPD patients. A alue below -950 were structural b e h 001 p<0.00 COPD without emphysema COP emph d log 10 V/Q histo %=129%); c, d, Q histogram of ma (63yrs, F AA% map, log e COPD patient w %=8.30%). The wed in red. Fig2: illustrate differen between and 2 C subgrou Fig3: T the sig correlat LAA% quartile V/Q in COPD. OE-MRI and s er 1,2 , and Josephin Biomedical Imagin D, Lund, Sweden, ited Kingdom ic obstructive pu y using oxygen a rom dynamic OE CT slices; 2) to tients. . Dynamic OE-M acquisition single weighted dynam with a single TI= physiological m 8 matrix, 10 m A single slice wh 0 Hounsfield un ly classified in 01 PD with hysema ogram of a mal , e) LAA% map f a male COPD FEV 1 % =72% g 10 V/Q map an with emphysem low attenuation The box plo es the significan ce of IQR-V/Q n healthy group COPD structura ups. The graph show gnificant positiv tion between and the inte e range of log 1 emphysematou structural CT ne H Naish 1,2 ng Institute, The 5 AstraZeneca R&D ulmonary diseas as a contrast agen E-MRI data [1,2 explore the loca MRI: Baseline T e shot turbo spi mic acquisition t =1100ms. A singl model to generat m thickness, fre hich best-matche nits (LAA%) wa to 2 subgroups e p, D %, d a n ot nt Q p al ws e n er 10 us D, se nt. ]. al T 1 in to le te ee ed as s: 1345 Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)
Transcript of Ven t ilation-perfusion mismatch in COPD with or …...ange of TI (50, itchover from m s were...
Vent
1Im
Univer
INTRO(COPDRecenThe airelatio
METHmappiecho smonitocoronaV/Q mbreaththe McalculLAA%
RESUin whistructuV/Q mand soentire in a nabroadesubgroincreahistogis no sIn addthree and IQsignifisignifi
DISCpresenincreainclud
CONCemphyOE-Mbetwefrom doption
REFEp.2516ACKN
tilation-perfus
Weijuan Zhang1,2
maging Sciences, S
rsity of Manchester
C
ODUCTION X-rD), while dynam
ntly a physiologiim of this study onship between C
HODS Dynamicing was performsequence (IR-HAor the change inal slice was acqumaps [1,2]. Othehing, no respirato
MRI image was sated to denote
%<2.5%--non-em
ULTS As can be ich the areas wiure. However, in
maps become hetome areas of inclung can also be
arrow range wither with longer toups, the V/Q mased inter quartigram) in COPD ssignificant differdition, median lsubgroups. FiguQR-V/Q in emicant correlationicant correlation
USSION COPDnt. Within the asing emphysemding airway block
CLUSION Conysematous and n
MRI estimated Ven these two COdynamic OE-MRn in the assessme
ERENCES 1) N6. 2) Hubbard, NOWLEDGEM
sion mismatch
, Penny L Hubbard
School of Cancer &
r, Manchester, Uni
Chamwood, United
ray computed tommic oxygen-enha
cal model has beis: 1) to comparCT measured em
c OE-MRI and mmed while subjecASTE) with a r
n T1 during gas swuired. All image
er parameters weory or cardiac trselected for eacthe fraction of
mphysema type (
seen in figure1,thout enhancemn the COPD lunterogeneous withcreased V/Q (ore illustrated by hh a sharp peak, wtails. Although t
maps and histograile range of logsubjects when crence between thlog10 V/Q was nure3 shows a si
mphysematous Cn in non-emph
n between median
D has regional Vslice, V/Q dista, while in non-kage and inflam
nsiderably heternon-emphysemaV/Q heterogeneiOPD subtypes. RI using a non-ioent of COPD.
Naish, J.& ParkeP, et al. Proc
MENT This stud
h in COPD wi
d1,2, Eva Bondesso
& Enabling Scienc
ited Kingdom, 3Sem
d Kingdom, 6Unive
mography (CT) anced (OE-) MRIeen proposed to e the V/Q maps
mphysema and O
multislice CT wects breathed merange of TI (50,witchover from mes were registereere: TR/TE 5500riggering. Quanth subject. The pemphysema. A
(8 patients), LAA
a healthy lung sment (in dark blu
ng, whether or h some areas of range and red). histograms. In thwhile in the COPthe LAA% are qams look simila
g10 V/Q (IQR-V/ompared with h
he COPD groupsnot significantlygnificant positiv
COPD (r=0.449,hysematous COPn log10 V/Q and
V/Q mismatch tribution becomemphysematous
mmation, maybe r
rogeneous V/Q atous COPD. Hoity and CT meThe added physonising source o
r, G. Proc 18th 18th Intl Soc M
dy was funded by
ith or without
on3, Lars Wigström
ces, The University
mcon Drug Develo
ersity Hospital of S
is powerful in eI enables assessmextract pulmonain COPD patien
OE-MRI measure
ere carried out odical air (21% O 300, 1100, 200medical air to 10ed to the end ex0 ms/3 ms, 68 ptitative CT: Mulproportion of lu
According to theA%≥2.5%--emp
shows a homogeue) seem to corre
not emphysemadecreased V/Q (The distribution
he healthy lung, PD lung, the histquite different fr. Figure2 show/Q, denoting thealthy subjects. s with and withoy different betwve correlation b p=0.017), whiPD. In additionLAA% in either
whether or notmes more heters COPD, other faresponsible for V
distribution prowever, the correasured emphyssiological informof contrast make
Intl Soc Mag RMag Reson Medy AstraZeneca.
emphysema:
m4, Simon S Young
y of Manchester, M
opment Consulting
South Manchester
estimating the stment of regionalary ventilation/pnts with or withoed ventilation-pe
on 24 COPD patO2) using an inv00 and 5000 ms00% O2 using th
xpiration positionphase-encoding stislice CT was p
ung area with ane 2D LAA%, Cphysema type (16
eneous V/Q mapespond to vessela is present, the(green and blue)n of V/Q in theV/Q distributes
togram becomesfor the 2 COPDs a significantlye width of the However there
out emphysema. een any of the etween LAA% ile there is no n, there is nor COPD group.
emphysema is ogeneous with actors, possibly V/Q change.
resents in both elation between
sema does varymation availablees it an attractive
eson Med 2010;d 2010; p.2515
Fig1: a, b) lohealthy subjeclog10V/Q mappatient withLAA%=0.53%log10V/Q histo(62yrs, FEV1areas in LAA%
comparison o
g5, David Singh6, G
Manchester, United
g, Lund, Sweden, 4
r Foundation Trust
tructural abnorml oxygen deliverperfusion (V/Q)out emphysema ierfusion imbalan
tients and 12 heaversion-recoverys). This was follhe same HASTEn and fitted pixesteps to reconstrperformed in COn attenuation va
COPD subjects 6 patients).
p, l e ), e s s
D y
n y e e
; .
a c d f g h
p<0.0
Healthy
LAA%
og10V/Q map anct (58yrs, FEV1p and log10V/Q
hout emphysem%); f, g, h) LAogram of a male%=67%, LAA%% maps are show
of functional O
Geoffrey JM Parke
d Kingdom, 2The B4AstraZeneca R&D
t, Manchester, Uni
malities of chronry and uptake bymaps directly fridentified in 2D
nce in COPD pat
althy volunteersy half Fourier alowed by a T1-w
E sequence but wel-by-pixel by a ruct a 128 x 128OPD patients. Aalue below -950were structural
b e h
001 p<0.00
COPD without emphysema
COPemph
d log10V/Q histo%=129%); c, d,
Q histogram ofma (63yrs, FAA% map, loge COPD patient w%=8.30%). The wed in red.
Fig2: illustratedifferenbetweenand 2 Csubgrou
Fig3: Tthe sigcorrelatLAA%quartileV/Q in COPD.
OE-MRI and s
er1,2, and Josephin
Biomedical Imagin
D, Lund, Sweden,
ited Kingdom
ic obstructive puy using oxygen arom dynamic OECT slices; 2) to
tients.
. Dynamic OE-Macquisition singleweighted dynam
with a single TI=physiological m
8 matrix, 10 m A single slice wh0 Hounsfield unly classified in
01
PD with hysema
ogram of a mal, e) LAA% mapf a male COPDFEV1% =72%
g10V/Q map anwith emphysemlow attenuation
The box ploes the significance of IQR-V/Q
n healthy groupCOPD structura
ups.
The graph showgnificant positivtion between
and the intee range of log1
emphysematou
structural CT
ne H Naish1,2
ng Institute, The 5AstraZeneca R&D
ulmonary diseasas a contrast agenE-MRI data [1,2 explore the loca
MRI: Baseline Te shot turbo spi
mic acquisition t=1100ms. A singlmodel to generatm thickness, fre
hich best-matchenits (LAA%) wa
to 2 subgroups
ep,D
%,dan
otntQpal
ws e n
er 10 us
D,
se nt. ]. al
T1
in to le te ee ed as s:
1345Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)
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