Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors...

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culogenesis and angiogenesis egrins in vasculature and KO phenotypes wth Factor Receptors signaling and vasculature phen VEGFR Tip cells VEGF, Notch

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Transcript of Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors...

Page 1: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Vasculogenesis and angiogenesis

Integrins in vasculature and KO phenotypes

Growth Factor Receptors signaling and vasculature phenotypesVEGFRTip cells VEGF, Notch

Page 2: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Vasculogesis and angiogenesis in vertebrates

Page 3: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Models Intussuseptive angiogenesis

(tissues as muscle, often blood flow dependent etc.)

Page 4: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Angiogenesis is a dynamic and context determined process

Page 5: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Examples of vascular defects

Page 6: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Integrins in the vasculature

Page 7: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

L1CAM

A7 Lm 68% embryonic lethal hemorrgaged E10-14.5 SM cells

Page 8: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Integrin inhibitors and RTK agonistic interactions (Kaan)

Page 9: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Angiopoitins, Tie1 and Tie2 receptor

Page 10: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

PDGF RTK signaling

Page 11: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

VEGF RTK signaling

Page 12: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 13: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

VEGFR3 at tips cells

Page 14: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 15: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Signaling in sprouting tip cells

Page 16: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Delta-Notch signaling

Page 17: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 18: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 19: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Sema3 inhibits integrin function. Normal angiogenesis…

semaphorins

Page 20: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 21: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 22: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 23: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Mouse models affecting TGFbeta signaling

Page 24: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 25: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Haemodynamics affect vascular remodelling

example

Page 26: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Pixt2 KO phenotypes in 6th BAAOcclusion of right BAAs results in Persistence of left 6 BAA

Page 27: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.
Page 28: Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Entoptic Visualization of the Retinal Vasculature …voi.opt.uh.edu/1990-IOVS-Entopicvisualizationoftheretinalvaculatu... · Entoptic Visualization of the Retinal Vasculature Near

Entoptic Visualization of the Retinal Vasculature …voi.opt.uh.edu/1990-IOVS-Entopicvisualizationoftheretinalvaculatu... · Entoptic Visualization of the Retinal Vasculature Near

A review of vasculogenesis modelsIn this review, we focus on mathematical models of in vitro vasculogenesis. The readers interested in the description of angiogenesis or wound healing,

A review of vasculogenesis modelsIn this review, we focus on mathematical models of in vitro vasculogenesis. The readers interested in the description of angiogenesis or wound healing,

Defining Phenotypes: Expanding Our Understanding … Asthma Phenotypes-Lockey.… · Defining Phenotypes: Expanding Our Understanding of Asthma Challenges in Treating a Heterogeneous

Defining Phenotypes: Expanding Our Understanding … Asthma Phenotypes-Lockey.… · Defining Phenotypes: Expanding Our Understanding of Asthma Challenges in Treating a Heterogeneous

Vasculature and innervation of skin ,

Vasculature and innervation of skin ,

Diagnostic Imaging of Pulmonary Vasculature

Diagnostic Imaging of Pulmonary Vasculature

Motor Phenotypes

Motor Phenotypes

Vasculogenesis and Diabetic Erectile Dysfunction

Vasculogenesis and Diabetic Erectile Dysfunction

Vasculature of LL

Vasculature of LL

Matrix stiffening promotes a tumor vasculature · PDF fileMatrix stiffening promotes a tumor vasculature phenotype ... and ex ovo models, ... Matrix stiffening promotes a tumor vasculature

Matrix stiffening promotes a tumor vasculature · PDF fileMatrix stiffening promotes a tumor vasculature phenotype ... and ex ovo models, ... Matrix stiffening promotes a tumor vasculature

Constitutional phenotypes

Constitutional phenotypes

Blood vasculature

Blood vasculature

A mechanochemical model of angiogenesis and vasculogenesis...In vitro models of vasculogenesis have shown that growth factors (VEGF-A) are required during these initial stages of blood

A mechanochemical model of angiogenesis and vasculogenesis...In vitro models of vasculogenesis have shown that growth factors (VEGF-A) are required during these initial stages of blood

Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes

Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes

Developmental ablation of Id1 and Id3 genes in the ... · Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes Qingshi Zhaoa, Amanda

Developmental ablation of Id1 and Id3 genes in the ... · Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes Qingshi Zhaoa, Amanda

Vasculature and innervation - USMF

Vasculature and innervation - USMF

Targeting vasculogenesis to prevent progression in ...ghobriallab.dana-farber.org/uploads/3/7/6/7/37679679/targeting... · Targeting vasculogenesis to prevent progression in multiple

Targeting vasculogenesis to prevent progression in ...ghobriallab.dana-farber.org/uploads/3/7/6/7/37679679/targeting... · Targeting vasculogenesis to prevent progression in multiple

In Vitro Models of Vasculogenesis and Angiogenesis › 2018 › 03 › in-vitro-mod… · models of vasculogenesis and angiogenesis that have been described to date and will critically

In Vitro Models of Vasculogenesis and Angiogenesis › 2018 › 03 › in-vitro-mod… · models of vasculogenesis and angiogenesis that have been described to date and will critically

Developmental Anatomy Retinoid Choroidal Vasculature

Developmental Anatomy Retinoid Choroidal Vasculature

1 Development of the Pulmonary Endothelium in …(a) Vasculogenesis (d) Vasculogenesis plus Angiogenesis (b) Sprouting Angiogenesis (c) Angiogenic Remodeling Figure 1.1 Schematic illustrating

1 Development of the Pulmonary Endothelium in …(a) Vasculogenesis (d) Vasculogenesis plus Angiogenesis (b) Sprouting Angiogenesis (c) Angiogenic Remodeling Figure 1.1 Schematic illustrating

Vasculature Physiologic Disturbances

Vasculature Physiologic Disturbances