VALUE-BASED HEALTHCARE STRATEGIES for better prostate … · 2017-03-20 · VALUE-BASED HEALTHCARE...
Transcript of VALUE-BASED HEALTHCARE STRATEGIES for better prostate … · 2017-03-20 · VALUE-BASED HEALTHCARE...
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VALUE-BASED HEALTHCARE STRATEGIES
for better prostate cancer outcomes
Frank Sullivan MB MRCPI FFRRSCI
Adjunct Professor in Medicine
Director, Prostate Cancer Institute, NUIG
IMSTA Annual Conference
22ND MARCH 2017
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Are these the new buzzwords in Irish healthcare?
• “Patient centred care” and “personalized medicine”
• “Money follows the patient” and “Value-based Healthcare” • How do we measure value?
• On what basis should the money “follow the patient”?
• Quality: Not everything you can count…counts!
• Value for money in Health in Ireland? • Are ‘Pharma and Med Tech’ the only sectors really being assessed?
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• How do doctors judge the value? (of E.G. surgery vs radiation)
• Regulators: what care do we permit/promote?
• HIQA
• Funders: What to reimburse?
• Government or Insurer
• NCPE/NICE
• Preferred providers
• Patients: What treatment to choose?
• Which hospital?
• Which doctor?
“Value is in the eye of the beholder”
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• Current approaches to healthcare “quality” or what passes for quality
• Importance/tyranny of the “PROM”
• Can measuring a PROM really make patients or healthcare better? • From PROMS to QALY’s
• Costs? Bring on the Health Economists! • From Uncle Sam to Bismarck to Beveridge
• “Research is not just for academics” • Importance to the Observational Study in determining Value
• Back to the future!
A snapshot of this talk?
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Prostate Cancer in Ireland
• Usually curable, early detection
• Incidence 3000 Irish men/per year
• Costs Eu45.6M (2010; Burns et al)
• Many options for men (early stage) • Active surveillance
• Surgery (open, lap, robotic)
• Radiation (EBRT, SRS, brachytherapy)
• Cyro, HIFU, PDT
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0.5 0.6 0.7 0.8 0.9 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8
WexfordKilkenny
MonaghanWaterfordTipperary
ClareLongford
MeathLimerick
LouthDublin
DonegalCavan
KildareKerry
CarlowWestmeath
WicklowOffalyMayoCork
LaoisRoscommon
SligoLeitrimGalway
observed/expected
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The Burden of Healthcare Costs Associated with Prostate Cancer in Ireland 2010 (R. Burns et al, submitted 2016) 45.6M
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• Current approaches to healthcare “quality” or what passes for quality
• Importance/tyranny of the “PROM”
• Can measuring a PROM really make patients or healthcare better? • From PROMS to QALY’s
• Costs? Bring on the Health Economists! • From Uncle Sam to Bismarck to Beveridge
• Research is not just for academics • Importance to the Observational Study
• Back to the future
A snapshot of this talk?
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So what are we measuring globally to show quality…and increase value in our health system? We are a long way from measuring the right stuff….
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Out of 674 clinical measures endorsed by NQF, only 208 classified as outcomes
466
0
100
200
300
400
500
600
700
No. of measures
NQF outcome measures
208
Non-outcome measures NQF measures
674
Note: Only measures endorsed by NQF included in this analysis Source: National Quality Forum
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Of those 208, only 124 are outcomes that matter to patients
84
0
20
40
60
80
100
120
140
160
180
200
220
Non-outcome measures (e.g., HbA1c, lipid levels)
Real outcome measures (mortality)
38
Real outcome measures (non-mortality)
86
NQF outcome measures
208
No. of measures
124 true outcome measures
(60%)
Note: Only measures endorsed by NQF included in this analysis Source: National Quality Forum
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What are the NCCP measuring as quality?
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How do doctors and researchers value prostate treatments?
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3/20/2017 13
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Outcomes are the powerful lever to unlock a value-based healthcare system
Value = Cost of delivering those outcomes
Patient health outcomes achieved
Improve outcomes
Starting point is to focus on
improving health results that
matter most for a patient's
condition
Reduce overall costs
Better quality of care is often less
expensive over the long-term
Increase value
Better quality care at
equal or lower cost leads to
higher value
in the system
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Outcomes also…eye of the beholder
• Value = Outcomes/Costs
• Outcomes What outcomes are needed?
• Health States CBA, CEA, CUA?
• Utility Experienced vs decision?
• How do we measure Utility as a public good or state of health? • Can we put a value on health?
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The Localized Prostate Cancer Working Group exists of physicians,
patients and registry leaders from across the world
Sweden Anna Bill-Axelson | Uppsala University Hospital; National Prostate Cancer Register (NPCR) of Sweden United Kingdom Adam Glaser | Leeds Teaching Hospitals NHS Trust James Catto | Academic Urology Unit and Academic Unit of Molecular Oncology, CR-UK/YCR Sheffield Cancer Research Centre
Ireland Frank Sullivan | Galway University Hospital; Prostate Cancer Institute at NUI Galway John Fitzpatrick | Irish Cancer Society Israel Jabob Ramon | Sheba Medical Center Italy Alberto Briganti | Vita-Salute San Raffaele University Hospital Netherlands Chris Bangma | Erasmus Medical Center
United States Steven Jay Frank | MD Anderson Cancer Center David Swanson | MD Anderson Cancer Center Andrew Vickers | Memorial Sloan-Kettering Cancer Center Adam Kibel | Dana-Farber Cancer Institute; Brigham and Women's Hospital Anthony D’Amico | Dana-Farber Cancer Institute; Brigham and Women's Hospital
Australia Kim Moretti | South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC); The Queen Elizabeth Hospital Mark Frydenberg | Prostate Cancer Registry of Victoria; Monash University Ian Roos* | Melbourne Graduate School of Education, University of Melbourne; Cancer Voices Victoria
Germany Hartwig Huland & Markus Graefen | Martini-Klinik at University Medical Center Hamburg-Eppendorf Michael Froehner | University Hospital Carl Gustav Carus, Technical University of Dresden Günter Feick* | Bundesverband Prostatakrebs Selbsthilfe (BPS); Europa UOMO Thomas Wiegel | University Hospital Ulm
Neil Martin | Dana-Farber Cancer Institute; Brigham and Women's Hospital Michael Blute | Massachusetts General Hospital Howard Sandler | Cedars-Sinai Medical Center Ronald Chen | University of North Carolina Lineberger Comprehensive Cancer Center Daniel Hamstra | University of Michigan Health System Ashutosh Tewari | Icahn School of Medicine at Mount Sinai Hospital *Patient representative
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Galway prostate brachytherapy outcomes study (2006-2020)
• Retrospective cohort study for outcomes [n=1350] 2006-2016
• Prospective cohort study for value [n=300] 2016-2020
• Goals:
• Better patient decision tools
• Better information for policy makers
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Galway prostate suite of outcomes for “value” 5 domains
1. Risk stratification (who are you treating?)
2. Disease metrics (alive, dead, relapsed)
3. Chance of harm provider measured
4. Patient reported outcomes (PROM’s)
5. Costs
19 Defining a Standard Set of Patient-centered Outcomes for Men with Localized Prostate Cancer; Martin,…Sullivan et al. in Eur Urol, 2015;67:460-7.
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Galway Brachytherapy: Survival and Relapse rates
Patient Characteristics Category Number Percentage
Recurrence Event No 476 95.6%
Yes 22 4.4%
Survival Alive 497 99%
Death from PrCa 2 0.4%
Death other cause 3 0.6%
0.00
0.25
0.50
0.75
1.00
Ove
rall
Sur
viva
l
0 1 2 3 4 5
Years Since Brachytherapy
Overall Patient Survival
0.00
0.25
0.50
0.75
1.00
Rec
urra
nce
Free
Sur
viva
l
0 1 2 3 4 5
Year Since Brachytherapy
Recurrence Free Survival
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Galway Brachytherapy: disease free survival curve by D’Amico Risk Categorisation
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• Current approaches to healthcare “quality” or what passes for quality
• Importance/tyranny of the “PROM”
• Can measuring a PROM really make patients or healthcare better? • From PROMS to QALY’s
• Costs? Bring on the Health Economists! • From Uncle Sam to Bismarck to Beveridge
• Research is not just for academics • Importance to the Observational Study
• Back to the future
A snapshot of this talk?
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Literature Review
Relieved
Unrelieved
Dead
Has health related outcome measures moved past this simple three point
model ?
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EPIC CP Questionnaire
EPIC-CP Questionnaire
Sensitive to treatment related Quality of Life changes over time
Split into five domains: • UIS: Urinary Incontinence Symptom Score
(out of 12) • UIOS: Urinary Irritation/Obstruction
Symptom Score (out of 12) • BS: Bowel Symptom Score (out of 12) • SS: Sexual Symptom Score (out of 12) • VHS: Vitality/Hormonal Symptom Score (out
of 12)
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• Current approaches to healthcare “quality” or what passes for quality
• Importance/tyranny of the “PROM”
• Can measuring a PROM really make patients or healthcare better? • From PROMS to QALY’s
• Bring on the Health Economists! • From Uncle Sam to Bismarck to Beveridge
• Research is not just for academics • Importance to the Observational Study
• Back to the future
A snapshot of this talk?
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Galway PCI Brachytherapy: n= 473 patients EPIC-CP domain scores at baseline and all follow up
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Quality of Life and Satisfaction with outcome among Prostate Cancer
Patients (Sanda; NEJM, 2008)
Figure 1. Changes in Quality of Life after
Primary Treatment for Prostate Cancer.
The graphs show unadjusted changes in
mean quality-of-life scores over time for
each domain, stratified according to
study group. Scores on the Expanded
Prostate Cancer Index Composite
domains range from 0 to 100, with
higher values representing a more
favourable health-related quality of life.
(Sanda et al. NEJM, 2008)
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September 14, 2016, at NEJM.org.
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What is a QALY and how does it help?
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Cost
effectiveness
It’s all about the QALY
Utility
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For PROMS to yield QALY’s in Prostate Cancer • Value must be disease/condition specific (Porter et al)
• PROM’s are disease/domain specific • Urinary • Bowel • Sexual • General
• QALY for CUA/CEA must be generalizable
• Must involve utility measurement
• Measured with different instruments (e.g. EQ5D5L)
• Do we need a link from EQ5D5L to prostate cancer?
• PORPUS?
Dolan, Kahneman. Economic Journal, 118 (January) 215-234
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Linking utility to PROM
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• Current approaches to healthcare “quality” or what passes for quality
• Importance/tyranny of the “PROM”
• Can measuring a PROM really make patients or healthcare better? • From PROMS to QALY’s
• Costs? Bring on the Health Economists! • From Uncle Sam to Bismarck to Beveridge
• Research is not just for academics • Importance to the Observational Study
• Back to the future
A snapshot of this talk?
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What about the “costs” part of the value?
• Health Economic Approaches
• Welfarist and extra-welfarist frameworks • Cost benefit • Cost effectiveness • HTA’s • ? Market Value “willingness to pay” • Cost of illness studies • Top down/bottom up • Top slicing public or health insurance data • Time driven/activity based costing
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The Burden of Healthcare Costs Associated with Prostate Cancer in Ireland 2010 (R. Burns et al, submitted 2016) 45.6M
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GUH: Radiation beam vs. Brachytherapy Seeds
Activity Activity Qty
Total cost Unit cost Per
Patient
New Patient Visit 5 763
153
Volume Study 3 568
114
Rad Information 5 358
72
CT Simulation (2 activities bundled)
9 +8 2,135
427
Contouring 7 1,106
221
U/S IGRT Preparation (3 activities bundled)
6 +6+5 1405
281
IMRT Planning (8 activities bundled) 5 (x 8) 6,972
1,395
RT Peer Review 5 702
140
External Beam Treatment 185 20,163
4,033
OTV (Nursing) 44 2,720
543
Follow-up Visit 12 1,204
241
Phone Consult 2 32
6
Grand Total 342 38,136 7,627
Activity Activity
Quantity Total cost
Unit cost Per Patient
New Patient Visit: 1 5 763 153
Volume Study 6 1,135 227
Brachy Planning Seed 4 219 44
Pre Assess Clinic 5 240 48
Permanent Implant Pr 5 19,114 3,823
OTV (Nursing) 1 60 12
CT Simulation 5 616 123
Dosimetry Approval 3 397 79
CT Scan Post Procedure 5 1,250 250
Follow-up Visit 14 1,405 281
Phone Consult 3 48 10
Grand Total 56 25,245 5,049
Activity Activity Qty Total cost Unit cost Per
Patient
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The cost truth and healthcare?
• Somewhere in the middle
• Not purely “top down”
• Not purely “activity based”
• Effectiveness must be factored in
• CEA/CUA/CBA • Uncle Sam/Porter/Beveridge/Bismarck
• However we do it, we must find a way to factor costs into everyone’s equation!
• Not just IMSTA
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• Current approaches to healthcare “quality” or what passes for quality
• Importance/tyranny of the “PROM”
• Can measuring a PROM really make patients or healthcare better? • From PROMS to QALY’s
• Bring on the Health Economists! • From Uncle Sam to Bismarck to Beveridge
• Research is not just for academics • Importance to the Observational Study in Value
• Back to the future
A snapshot of this talk?
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Galway prostate brachytherapy outcomes study (2006-2020)
• Retrospective cohort study for outcomes [n=1350] 2006-2016
• Prospective cohort study for value [n=300] 2016-2020
• Goals:
• Better patient decision tools
• Better information for policy makers
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Prostate Cancer Galway ‘BT- Value’ Project:
• Disease/condition focus (early state prostate cancer) • Treatment focus (brachytherapy)
• PROM combined with toxicities (AE) = Global Health Status
• Delta is the change in PROM/QALY with time
• Probability from side effect data (AE)
• Utility from discrete choice experiments (DCE and PORPUS)
• Costs from activity based costs but phase specific
• CUA = Costs/QALY = Value!
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• Current approaches to healthcare “quality” or what passes for quality
• Importance/tyranny of the “PROM”
• Can measuring a PROM really make patients or healthcare better? • From PROMS to QALY’s
• Bring on the Health Economists! • From Uncle Sam to Bismarck to Beveridge
• Research is not just for academics • Importance to the Observational Study
• Back to the future!
A snapshot of this talk?
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Communicating Value in Health Care Using Radar Charts: A Case Study of Prostate Cancer Nikhil G. Thaker, MD, Tariq N. Ali, MD, MBA, Michael E. Porter, PhD, MBA, Thomas W. Feeley, MD, Robert S. Kaplan, PhD,
and Steven J. Frank, MD. Volume 12 / Issue 9 / September 2016
Can we use this to help patients?
Need for more effective tools
Copyright © 2016 by American Society of Clinical Oncology Volume 12 / Issue 9 / September 2016 n jop.ascopubs.org
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The future of Value in Healthcare: Policy Makers
• We now have the methodology to measure value across the different treatments for localized prostate cancer • Cost/QALY comparison (surgery, radiation, brachy)
• Akin to a HTA for the NCPE!
• Transparency in outcomes and value for regulators, patients and payers • Altered payment structure: payment for quality
• Staggered payments, bundled payments
• Changes in health delivery structures: integrated provider units
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The future of Value in Healthcare: Patient decision tools
• Complex decision (E.G. surgery, radiation, brachytherapy)
• Multiple attributes • Chance of cure the same • Chances of serious harm with all, but quite rare • QOL • Costs?
Behavioral economics • Importance of utility • Discrete choice experiments (ongoing)
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• Patients can find out a lot about the correct treatment for them:
• Doctor/nurse consultation
• Personal research
• Online research
• Other: media etc
• But how can the patient find the best doctor/healthcare facility for them?
• Why can’t you google the best
doctor for prostate cancer?
• Lack of transparency
• Asymmetric market
• Non market ‘good’
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Summary
• CUA costs per QALY can be derived from a value (outcomes) approach
• Must be disease (condition) focussed
• If expanded across all treatment options, then cost effectiveness judgements possible/desirable
• Transparency for payers and patients
• Competition possible
• Value based healthcare to improve quality and lower global costs
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Acknowledgements and Thanks!
Prostate Cancer Healthcare Value Team:
• Radiation Oncology Teams (GUH, GC) • Rachel Lee (Axis Consulting)
• Brenda Dooley (Axis Consulting)
• Ruth Corcoran
• Davood Roshansangachin
• Brendan Kennelly
• Paddy Gillespie • Ciaran O’Neill
• Eamonn O’Shea
• Diarmuid O’Donovan
• Martin O’Donnell