Vaccines production in industrial level
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VACCINES
Akash Mali,India
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Basic laboratory services and media preparation for vaccine production
•Water
• Electricity
•Capital equipment
The production of a bacterial vaccine
•The Organism To Be Produced(Brucella abortus Strain 19)
•Growth Medium
•Fermentation Equipment
•Temperature And Ph Control(± 0.5°C.and 121°C down to 37°C in 20 to 30)
Lyophilization
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•Minimum Space ,Optimized Fermentor Design, Range -5 L-25000 L •Agitator(Top/bottom) ,Double mechanical Seal
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SELECTING THE STRAIN FOR VACCINE PRODUCTION
GROWING THE MICRO-ORGANISM
ISOLATION & PURIFICATION OF MICROORGANISM
INACTIVATION OF ORGANISM
FORMULATION OF VACCINE
Upstream
downstream
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Alum
Production strain Seed culture Fermentation Purification
Adjuvant
FillingLabeling Packaging
Inoculation
Inspection
Ultrafilteration
Glycine soln
Formaldehyde soln
Monosodium glutamate
Inactivation
Thimersol
Stabilizer
Preservative
Dilutant
Clostridium.tetani.(anaerobic species of pathogenic bacteria)
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