UW551 in!planta andinrichmedium SequenceIDAE@value28IPAE ...

Supplemental Table 1A: Expression patterns of Ralstonia solanacearum UW551 in planta and in rich mediumSequence ID AE-‐value 28 IP AE-‐value 28 CPG Fold change Change P-‐value UW551 locus tag Ortholog? Rs Core Gene? Gene symbol Gene description638723153 15 13.86 2.42 up 3.53E-‐04 RRSL_00009 Hypothetical Protein638721049 9.91 7.84 4.65 up 1.24E-‐02 RRSL_00024 o c hrcC HrcC638723144 10.75 9.75 2.21 up 2.11E-‐02 RRSL_00036 o c Transcriptional regulator, GntR family638723121 9.91 8.3 3.39 up 4.83E-‐02 RRSL_00063 Hypothetical Protein638723122 12.88 10.77 4.76 up 5.15E-‐03 RRSL_00064 o c Chitinase( EC:3.2.1.14 )638723117 11.67 10.39 2.69 up 1.17E-‐02 RRSL_00089 o c Hypothetical Protein638723089 9.72 8.47 2.62 up 3.32E-‐03 RRSL_00107 o c Hypothetical Protein638723005 15.19 13.93 2.64 up 2.29E-‐04 RRSL_00169 Hypothetical Protein638723036 8.83 7.66 2.48 up 4.68E-‐02 RRSL_00198 probable sodium/solute symporter638723039 12.37 11.18 2.51 up 4.19E-‐02 RRSL_00201 o Phage protein638722949 10.43 8.84 3.33 up 2.76E-‐02 RRSL_00220 Hypothetical protein638722966 9.74 8.79 2.12 up 2.94E-‐02 RRSL_00237 Shikimate kinase( EC:2.7.1.71 )638722968 11.15 10.19 2.15 up 4.71E-‐03 RRSL_00240 o Transposase638722968 11.15 10.19 2.15 up 4.71E-‐03 RRSL_00240 o Transposase638722968 11.15 10.19 2.15 up 4.71E-‐03 RRSL_00240 o Transposase638722968 11.15 10.19 2.15 up 4.71E-‐03 RRSL_00240 o Transposase638722968 11.15 10.19 2.15 up 4.71E-‐03 RRSL_00240 o Transposase638722968 11.15 10.19 2.15 up 4.71E-‐03 RRSL_00240 o Transposase638722968 11.15 10.19 2.15 up 4.71E-‐03 RRSL_00240 o Transposase638722968 11.15 10.19 2.15 up 4.71E-‐03 RRSL_00240 o Transposase638723017 9.23 7.81 2.96 up 1.14E-‐02 RRSL_00256 Hypothetical Protein638722883 9.14 7.34 3.83 up 9.28E-‐03 RRSL_00271 Hypothetical Protein638722884 9.93 8.45 3.08 up 8.87E-‐05 RRSL_00272 Succinate-‐semialdehyde dehydrogenase (NADP+)( EC:1.2.1.16 )638722885 9.65 8.61 2.27 up 2.92E-‐02 RRSL_00273 Tartrate dehydrogenase( EC:1.1.1.93 )638722886 9.24 8.07 2.48 up 6.61E-‐03 RRSL_00274 Transporter638722887 11.84 9.28 6.5 up 2.71E-‐03 RRSL_00275 dppC DppC638722888 10.43 8.61 3.91 up 6.51E-‐03 RRSL_00276 dppB DppB638722889 9.92 8.01 4.14 up 1.52E-‐03 RRSL_00277 Dipeptide-‐binding protein638722890 8.99 7.89 2.38 up 1.78E-‐03 RRSL_00278 Oxidoreductase( EC:1.-‐ )638722891 10.69 8.59 4.71 up 2.60E-‐03 RRSL_00279 Probable 2-‐haloacid halidohydrolase IVa638722892 9.9 7.7 5.08 up 3.42E-‐02 RRSL_00281 Aldehyde dehydrogenase( EC:1.2.1.3 )638722893 9.68 8.11 3.29 up 3.27E-‐02 RRSL_00282 Aldehyde dehydrogenase( EC:1.2.1.3 )638722896 10.8 9.29 3.15 up 2.08E-‐03 RRSL_00286 Probable aminotransferase Y4UB( EC:2.6.1.-‐ )638722899 8.53 7.66 2.03 up 2.65E-‐02 RRSL_00290 Possible Glycine/D-‐amino acid oxidase (deaminating).638722943 10.87 9.73 2.42 up 1.16E-‐02 RRSL_00336 o c Transporter638722830 14.93 13.95 2.17 up 9.70E-‐03 RRSL_00348 o c Ferredoxin-‐-‐NADP reductase( EC:1.18.1.2 )638722778 11.08 10.21 2.02 up 4.95E-‐02 RRSL_00370 o c Transcriptional regulator, ArsR family638722779 12.92 11.62 2.72 up 6.25E-‐03 RRSL_00371 o c Cytochrome d ubiquinol oxidase subunit I( EC:1.10.3.-‐ )638722757 13.94 12.87 2.31 up 1.67E-‐02 RRSL_00423 o Hypothetical Protein638722760 8.56 7.5 2.3 up 4.71E-‐03 RRSL_00426 o c Conserved Hypothetical Protein638722772 8.66 7.5 2.47 up 3.22E-‐02 RRSL_00439 Benzoate 1,2-‐dioxygenase alpha subunit / Toluate 1,2-‐dioxygenase alpha subunit( EC:1.14.12.-‐,EC:1.14.12.10 )638722625 9.74 8.16 3.28 up 1.70E-‐03 RRSL_00472 Hypothetical protein638722638 10.85 9.46 2.9 up 1.11E-‐02 RRSL_00485 Hypothetical Protein638721073 9.83 8.13 3.59 up 9.17E-‐03 RRSL_00502 o c Hypothetical Protein638721071 9.84 8.21 3.42 up 1.81E-‐03 RRSL_00504 o c prhJ PrhJ638721070 14.01 9.66 22.45 up 5.08E-‐05 RRSL_00505 o c hrpG HrpG638721069 11 7 17.69 up 1.18E-‐04 RRSL_00506 o c hpaB HpaB638721068 13.3 9.5 15.32 up 1.26E-‐04 RRSL_00507 o c hrpZ HrpZ638721067 16.51 10.72 60.78 up 2.02E-‐06 RRSL_00508 o c hrpY HrpY638721066 13.18 9.95 10.39 up 1.80E-‐04 RRSL_00509 o c hrpX HrpX638721065 12.47 9.92 6.46 up 1.53E-‐03 RRSL_00510 o c hrpW HrpW638721064 11.67 9 6.99 up 1.23E-‐03 RRSL_00511 o c hrpV HrpV638721063 10.61 8.43 5.01 up 1.65E-‐03 RRSL_00512 o c hrcS HrcS638721062 12.1 8.74 11.29 up 1.66E-‐04 RRSL_00513 o c hrcR HrcR638721061 14.12 10.15 17.35 up 7.84E-‐05 RRSL_00514 o c hrcQ HrcQ638721060 10.28 7.94 5.59 up 1.67E-‐03 RRSL_00515 o c hpaP HpaP638721059 9.16 7.99 2.48 up 2.77E-‐02 RRSL_00516 o c hrcV HrcV638721058 8.76 7.5 2.64 up 3.92E-‐03 RRSL_00517 o c hrcU HrcU638721057 11.59 7.71 16.31 up 2.05E-‐04 RRSL_00518 o c hrpK HrpK638721056 10.21 7.94 5.29 up 1.09E-‐02 RRSL_00519 o c hrcJ HrcJ638721055 9.66 7.46 5.07 up 7.60E-‐03 RRSL_00520 o c hrpH HrpH638721054 8.93 7.58 2.82 up 2.74E-‐02 RRSL_00522 o c hrpF HrpF638721053 11.4 8.5 8.22 up 1.22E-‐03 RRSL_00523 o c hrcN HrcN638721052 10.34 8.41 4.2 up 2.50E-‐03 RRSL_00524 o c hrpD HrpD638721051 12.92 10.78 4.87 up 3.25E-‐04 RRSL_00525 o c hrcT HrcT638722662 10.08 9.08 2.21 up 4.10E-‐03 RRSL_00531 o c Leucine-‐rich repeat family protein638722663 10.51 8.69 3.9 up 9.52E-‐04 RRSL_00532 o cd00116, LRR_RI, Leucine-‐rich repeats (LRRs), ribonuclease inhibitor (RI)-‐like subfamily.638722665 9.17 7.76 2.92 up 2.03E-‐03 RRSL_00534 o c Pyruvate dehydrogenase E1 component beta subunit( EC:1.2.4.1 )638722666 9.17 7.79 2.87 up 1.68E-‐03 RRSL_00535 o c Pyruvate dehydrogenase E1 component alpha subunit( EC:1.2.4.1 )638722667 10.19 8.84 2.82 up 3.59E-‐03 RRSL_00537 Glutathione S-‐transferase( EC:2.5.1.18 )638722672 9.42 8.1 2.74 up 4.94E-‐02 RRSL_00542 o c Hypothetical Protein638722576 9.07 7.45 3.4 up 8.77E-‐04 RRSL_00571 o Hypothetical Protein638722579 13.19 11.59 3.35 up 4.00E-‐04 RRSL_00575 o Hypothetical Protein638722580 11.89 10.26 3.41 up 1.51E-‐03 RRSL_00576 o c Hypothetical Protein

638722582 11.1 9.22 4.08 up 7.49E-‐03 RRSL_00578 o c RNA polymerase sigma-‐f factor for flagellar operon (fliA)638722585 10.59 8.51 4.66 up 1.59E-‐02 RRSL_00581 o c Transmembrane flagellar biosynthesis protein (flhA)638722587 11.55 10.61 2.12 up 5.92E-‐03 RRSL_00583 o c Transcriptional regulator, TetR family638722589 10.4 7.86 6.41 up 1.40E-‐02 RRSL_00585 o c 3-‐dehydroquinate dehydratase( EC:4.2.1.10 )638722737 12.5 10.63 4.04 up 1.31E-‐02 RRSL_00596 o c hypothetical protein638722738 14.23 12.65 3.32 up 9.98E-‐04 RRSL_00597 o c VirK protein638722741 11.19 9.51 3.52 up 9.06E-‐03 RRSL_00600 hypothetical protein638722869 13.25 11.8 3.01 up 4.06E-‐03 RRSL_00617 o c alpha-‐ketoglutarate permease, kgtP2638722698 9.55 7.78 3.76 up 5.09E-‐03 RRSL_00634 o Hypothetical Protein638722710 8.46 7.52 2.11 up 1.47E-‐02 RRSL_00650 o c Probable chemotaxis phosphatase (cheZ1)638722711 8.9 7.98 2.08 up 1.39E-‐02 RRSL_00651 o c Probable chemotaxis response regulator protein (cheY1)638722562 9.13 8.19 2.11 up 2.74E-‐02 RRSL_00668 o c dppB DppB638722574 10.91 9.89 2.24 up 8.89E-‐03 RRSL_00680 o c Probable transmembrane methyl-‐accepting chemotaxis protein638722409 12.01 10.24 3.77 up 1.76E-‐02 RRSL_00681 Hypothetical protein638722410 12.82 11.47 2.81 up 2.76E-‐02 RRSL_00682 o Hypothetical Protein638722416 9.42 8.27 2.45 up 1.76E-‐02 RRSL_00688 o c probable transmembrane methyl-‐accepting chemotaxis protein638722417 9.55 8.64 2.08 up 1.17E-‐02 RRSL_00689 o c Mg(2+) transport ATPase protein C638722418 11.49 9.75 3.67 up 1.16E-‐04 RRSL_00690 o c Nucleoside-‐diphosphate-‐sugar epimerases638722419 8.66 7.63 2.26 up 3.78E-‐03 RRSL_00691 o c CoxI protein638722421 10.43 8.57 4 up 5.70E-‐03 RRSL_00694 o c ATP-‐dependent protease subunit638722423 12.03 9.29 7.36 up 1.58E-‐03 RRSL_00696 Hypothetical Protein638722424 9.06 7.94 2.4 up 7.90E-‐03 RRSL_00697 o c Carbon monoxide oxygenase (cytochrome b-‐561) large subunit( EC:1.2.2.4 )638722425 12.19 10.26 4.19 up 3.18E-‐04 RRSL_00698 o c Carbon monoxide oxygenase (cytochrome b-‐561) iron-‐sulfur subunit( EC:1.2.2.4 )638722426 15.21 13.91 2.73 up 1.34E-‐02 RRSL_00699 o c Hypothetical Protein638722432 9.67 8.66 2.21 up 3.88E-‐02 RRSL_00705 o Hypothetical Protein638722433 10.34 9.33 2.22 up 9.49E-‐03 RRSL_00706 o Hypothetical Protein638722438 10.52 9.42 2.36 up 4.11E-‐02 RRSL_00714 Catechol 1,2-‐dioxygenase( EC:1.13.11.1 )638722690 10.73 7.47 10.55 up 8.41E-‐05 RRSL_00752 o c Hypothetical Protein638722692 10.33 9.18 2.44 up 1.04E-‐02 RRSL_00754 o Probable chemotaxis response regulator protein (cheY2)638722695 9.78 7.18 6.7 up 5.52E-‐03 RRSL_00758 Hypothetical protein638722696 12.41 7.7 28.98 up 6.01E-‐04 RRSL_00759 o Nitric-‐oxide reductase subunit B( EC:1.7.99.7 )638722697 12.56 7.33 41.31 up 1.57E-‐03 RRSL_00760 o Hypothetical protein638722404 9.9 8.3 3.34 up 5.99E-‐04 RRSL_00782 Hypothetical protein638722405 13.62 12.33 2.7 up 1.82E-‐03 RRSL_00783 o c Hypothetical Protein638722406 13.44 12.02 2.96 up 3.20E-‐03 RRSL_00784 o Hypothetical Protein638722407 15.64 13.71 4.21 up 1.54E-‐05 RRSL_00785 o Hypothetical Protein638722408 12.9 11.69 2.55 up 3.76E-‐03 RRSL_00786 o Hypothetical Protein638722727 12.02 11.03 2.2 up 1.11E-‐02 RRSL_00801 o c livG LivG638722728 10.25 9.22 2.25 up 2.61E-‐03 RRSL_00802 o c livF LivF638722729 13.59 11.84 3.72 up 1.22E-‐04 RRSL_00803 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638722730 12.06 10.65 2.93 up 1.56E-‐03 RRSL_00804 o c livH LivH638722731 11.84 10.75 2.35 up 1.21E-‐02 RRSL_00806 o c livM LivM638722335 11.02 9.77 2.61 up 4.91E-‐03 RRSL_00811 o c Kup system potassium uptake protein638722342 12.15 10.77 2.87 up 3.03E-‐02 RRSL_00819 o c Amino acid permease638722361 11.62 9.88 3.68 up 1.24E-‐02 RRSL_00837 Transcriptional regulator638722456 10.7 9.41 2.71 up 9.01E-‐03 RRSL_00906 o Outer membrane porin protein 32 precursor638722457 9.49 8.4 2.34 up 1.26E-‐02 RRSL_00907 o Alpha-‐glucosidase( EC:3.2.1.20 )638722458 9.74 7.86 4.07 up 7.85E-‐03 RRSL_00908 o Hexuronate transporter638722460 10.47 9.5 2.17 up 1.03E-‐02 RRSL_00909 o c Transcriptional regulator, GntR family638722459 12.61 9.08 12.75 up 1.11E-‐02 RRSL_00910 o c Glucarate dehydratase( EC:4.2.1.40 )638722309 10.79 9.39 2.92 up 5.18E-‐03 RRSL_00926 o Hypothetical Protein638722314 10.08 8.73 2.82 up 2.54E-‐02 RRSL_00931 Hypothetical Protein638722330 14.25 9.68 26.1 up 8.14E-‐05 RRSL_00947 o c Hypothetical Protein638722382 10.63 9.52 2.38 up 1.07E-‐02 RRSL_00974 o c Hypothetical Protein638722511 13.02 11.76 2.64 up 4.69E-‐02 RRSL_00997 Hypothetical protein638722088 10.79 8.95 3.95 up 9.52E-‐04 RRSL_01013 o c Hypothetical Protein638722089 9.28 8.18 2.37 up 1.85E-‐02 RRSL_01014 o c conserved hypothetical protein638722091 10.05 8.94 2.39 up 1.80E-‐02 RRSL_01016 o c Hypothetical Protein638722092 10.29 8.43 4.01 up 1.90E-‐03 RRSL_01017 o c Invasion protein IAGB638722093 9.47 8.4 2.31 up 3.94E-‐03 RRSL_01018 o c Probable transmembrane methyl-‐accepting chemotaxis protein638722094 13.44 9.57 16.08 up 3.00E-‐05 RRSL_01019 Hypothetical Protein638722095 13.06 8.8 21.16 up 9.95E-‐05 RRSL_01020 Atypical ORF638722096 12.16 10.35 3.87 up 2.58E-‐03 RRSL_01021 o c Hypothetical Protein638722097 10.1 7.73 5.69 up 1.10E-‐03 RRSL_01022 o Hypothetical Protein638722101 9.95 8.32 3.42 up 1.81E-‐02 RRSL_01027 o c Gluconolactonase( EC:3.1.1.17 )638722104 9.34 8.05 2.7 up 8.43E-‐04 RRSL_01030 o c Glucarate dehydratase( EC:4.2.1.40 )638722105 10.49 8.83 3.48 up 5.77E-‐03 RRSL_01031 o c Glucarate/galactarate transporter638722107 11.39 8.27 9.62 up 1.41E-‐03 RRSL_01033 o c 5-‐dehydro-‐4-‐deoxyglucarate dehydratase( EC:4.2.1.41 )638722108 11.3 9.28 4.48 up 2.08E-‐03 RRSL_01034 o c Spermidine synthase( EC:2.5.1.16 )638722044 11.58 9.86 3.64 up 4.15E-‐03 RRSL_01069 hypothetical protein638722045 14.36 11.98 5.75 up 4.09E-‐04 RRSL_01070 Hypothetical Protein638722049 8.29 7.29 2.21 up 4.00E-‐02 RRSL_01074 o ybtP YbtP638721965 11.83 10.75 2.33 up 2.83E-‐03 RRSL_01114 Hypothetical Protein638721967 9.24 8.04 2.53 up 3.91E-‐03 RRSL_01117 o c Assimilatory nitrate reductase small subunit( EC:1.7.1.2 )638721968 8.96 8.04 2.09 up 1.76E-‐02 RRSL_01118 o c Hypothetical Protein638721969 10.7 8.84 4.01 up 3.86E-‐03 RRSL_01119 o c Nitrite reductase [NAD(P)H] large subunit( EC:1.7.1.4 )

638721970 10.64 8.99 3.46 up 3.26E-‐03 RRSL_01120 o c Transporter638721971 8.8 7.53 2.66 up 1.84E-‐02 RRSL_01121 o Probable aerotaxis receptor (aer1)638721973 10.35 9.14 2.56 up 4.62E-‐02 RRSL_01123 o c Hypothetical Protein638721985 8.28 7.39 2.04 up 9.94E-‐03 RRSL_01136 o c Hypothetical Protein638721675 13.66 12.51 2.44 up 2.97E-‐02 RRSL_01193 o c Hypothetical Protein638722119 11.27 9.17 4.73 up 8.45E-‐04 RRSL_01204 Hypothetical Protein638722120 9.74 8.82 2.09 up 1.12E-‐02 RRSL_01205 Site-‐specific recombinases638722122 11.83 10.97 2.01 up 4.68E-‐03 RRSL_01207 Predicted transcriptional regulators638722055 9.76 8.65 2.37 up 2.92E-‐02 RRSL_01251 Hypothetical Protein638722085 10.3 8.48 3.91 up 1.70E-‐03 RRSL_01283 o c Hypothetical Protein638722209 9.35 8.1 2.63 up 3.74E-‐03 RRSL_01292 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638722220 9.18 8.26 2.09 up 3.20E-‐03 RRSL_01304 o c Hypothetical Protein638722221 11.96 10.45 3.13 up 3.23E-‐03 RRSL_01305 o c ABC transporter substrate-‐binding protein638722222 12.48 11.07 2.94 up 4.14E-‐02 RRSL_01306 o c ABC transporter permease protein638722227 15.89 14.89 2.2 up 1.95E-‐03 RRSL_01312 o c Hypothetical Protein638722228 16 14.75 2.63 up 1.24E-‐04 RRSL_01313 o c Hypothetical Protein638721917 14.62 13.59 2.26 up 1.18E-‐03 RRSL_01378 o c Hypothetical Protein638721865 11.43 9.33 4.7 up 1.19E-‐03 RRSL_01397 o c Iron-‐Sulfur 4Fe-‐4S Ferredoxin638721866 13.11 9.61 12.46 up 1.09E-‐03 RRSL_01398 o c cytochrome c oxidase, diheme subunit, membrane-‐bound( EC:1.9.3.1 )638721867 10.62 7.36 10.57 up 5.90E-‐04 RRSL_01399 o c Hypothetical Protein638721868 11.19 8.76 5.98 up 7.90E-‐03 RRSL_01400 o c cytochrome c oxidase, monoheme subunit, membrane-‐bound( EC:1.9.3.1 )638721869 12.5 10.38 4.78 up 4.20E-‐04 RRSL_01401 o c Cytochrome c oxidase polypeptide I( EC:1.9.3.1 )638721870 12.23 9.74 6.17 up 2.56E-‐04 RRSL_01402 o c fixS FixS638721871 8.49 7.56 2.11 up 3.90E-‐02 RRSL_01403 o c Nitrogen fixation protein fixI (E1-‐E2 type cation ATPase fixI)( EC:3.6.3.-‐ )638722484 10.69 8.98 3.61 up 1.87E-‐04 RRSL_01439 o Ankyrin repeat protein638722264 10.72 8.54 5 up 2.59E-‐03 RRSL_01478 o c Transporter638722265 9.99 8.81 2.5 up 1.71E-‐02 RRSL_01480 Multidrug resistance protein B638722175 11.5 10.12 2.88 up 2.72E-‐03 RRSL_01504 o c Tryptophan 2,3-‐dioxygenase( EC:1.13.11.11 )638722176 10.48 9.36 2.39 up 1.57E-‐03 RRSL_01505 o c L-‐kynurenine hydrolase( EC:3.7.1.3 )638722179 10.63 9.46 2.49 up 2.81E-‐02 RRSL_01508 o c Hypothetical Protein638722193 11.63 10.49 2.42 up 1.18E-‐02 RRSL_01522 o c Hypothetical Protein638721748 10.33 8.69 3.43 up 4.29E-‐02 RRSL_01545 o Alkanesulfonates transport system permease protein638721750 11.02 10.15 2.01 up 4.27E-‐02 RRSL_01547 o c Probable molybdenum-‐pterin binding protein638721753 8.88 7.91 2.17 up 3.98E-‐02 RRSL_01550 o c cysT CysT638721754 11.21 8.75 6.06 up 4.13E-‐02 RRSL_01551 o c cysW CysW638721756 9.14 7.57 3.28 up 7.58E-‐03 RRSL_01554 o Hypothetical Protein638721757 9.59 8.29 2.73 up 3.15E-‐02 RRSL_01555 o Hypothetical Protein638721763 13.34 9.21 19.35 up 1.04E-‐04 RRSL_01562 o c Leucine-‐rich repeat family protein638721764 10.06 8.26 3.84 up 3.00E-‐02 RRSL_01563 Atypical orf638721765 13.3 11.82 3.07 up 2.32E-‐03 RRSL_01564 o c Isocitrate lyase( EC:4.1.3.1 )638721785 15.5 12.59 8.29 up 6.96E-‐04 RRSL_01586 o Hypothetical Protein638721688 12 8.67 11.13 up 1.29E-‐04 RRSL_01625 o Hypothetical Protein638721730 13.46 12.17 2.7 up 5.51E-‐03 RRSL_01669 Hypothetical Protein638721732 14.2 12.89 2.73 up 2.62E-‐03 RRSL_01671 o c Hypothetical Protein638721542 12.08 10.93 2.44 up 3.13E-‐03 RRSL_01690 o c Hypothetical Protein638721567 15.84 12.66 9.98 up 3.61E-‐04 RRSL_01716 o c Hypothetical Protein638721575 9.63 8.11 3.16 up 4.29E-‐02 RRSL_01724 o Alcohol dehydrogenase( EC:1.1.1.1 )638721585 12.73 9.89 7.92 up 3.97E-‐04 RRSL_01783 Hypothetical Protein638721603 12.11 10.1 4.46 up 5.66E-‐03 RRSL_01802 o Atrazine chlorohydrolase( EC:3.8.1.8 )638721604 11.06 10.15 2.08 up 3.53E-‐02 RRSL_01803 o c Carboxypeptidase S( EC:3.4.17.4 )638721608 9.35 8.47 2.03 up 1.58E-‐02 RRSL_01808 Hypothetical Protein638721619 8.38 7.52 2.01 up 5.13E-‐03 RRSL_01819 o c Probable transmembrane methyl-‐accepting chemotaxis protein638721397 13.61 8.91 28.74 up 6.14E-‐04 RRSL_01886 o c Outer membrane protein638721432 10.02 9.14 2.03 up 1.05E-‐02 RRSL_01921 o c Probable transmembrane methyl-‐accepting chemotaxis protein638721448 11.19 7.92 10.63 up 3.45E-‐02 RRSL_01938 o c Ferredoxin-‐-‐NAD(P)(+) reductase( EC:1.18.1.-‐ )638720756 13.9 11.77 4.81 up 4.32E-‐03 RRSL_02046 Hypothetical Protein638720757 16.03 12.77 10.58 up 1.79E-‐03 RRSL_02047 Hypothetical Protein638720758 9.46 8.09 2.84 up 3.25E-‐02 RRSL_02048 Hypothetical Protein638720767 15.14 13.42 3.63 up 6.52E-‐04 RRSL_02057 Uncharacterized protein conserved in bacteria638720768 13.39 11.62 3.74 up 6.26E-‐04 RRSL_02058 Hypothetical Protein638720772 13.52 12.09 2.98 up 2.62E-‐02 RRSL_02063 Hypothetical Protein638720800 11 8.51 6.19 up 8.72E-‐05 RRSL_02094 o c Hypothetical Protein638720803 12.83 11.68 2.45 up 2.04E-‐02 RRSL_02098 o c Flagellar transcriptional activator (flhD)638720804 13.74 12.06 3.55 up 8.12E-‐04 RRSL_02099 o c Flagellar transcriptional activator (flhC)638720805 10.09 8.44 3.45 up 1.38E-‐03 RRSL_02100 o c Probable chemotaxis motA protein638720806 10.59 8.92 3.5 up 5.67E-‐03 RRSL_02101 o c Probable chemotaxis motB protein638720807 9.86 8.5 2.84 up 1.31E-‐02 RRSL_02102 o c Probable chemotaxis response regulator protein (cheY)638720808 9.17 8.17 2.22 up 1.59E-‐02 RRSL_02103 o c Probable chemotaxis sensor histidine kinase (cheA)638720809 9.11 8 2.39 up 4.08E-‐03 RRSL_02104 o c Probable chemotaxis coupling protein (cheW)638721172 11.67 10.16 3.14 up 2.61E-‐03 RRSL_02152 Hypothetical protein638721173 11.3 10.3 2.2 up 2.34E-‐02 RRSL_02153 o Hypothetical protein638721179 13.37 10.83 6.43 up 6.72E-‐04 RRSL_02159 Hypothetical protein638721180 10.81 9.37 2.98 up 1.19E-‐02 RRSL_02160 o Myo-‐inositol uptake ATP-‐binding protein638721181 12.08 10.58 3.13 up 3.43E-‐03 RRSL_02161 o Myo-‐inositol transport system permease protein638721183 10.12 8.77 2.81 up 2.44E-‐02 RRSL_02163 o IolD PROTEIN638721184 11.01 9.67 2.8 up 8.94E-‐03 RRSL_02164 o IolE protein

638721185 11.77 10.71 2.29 up 1.81E-‐02 RRSL_02165 o IolB protein638721186 11.5 10.01 3.1 up 3.36E-‐03 RRSL_02166 Hypothetical protein638720960 9.97 8.81 2.46 up 6.33E-‐03 RRSL_02178 o c pstA PstA638720961 10.06 9.06 2.2 up 1.82E-‐02 RRSL_02179 o c pstC PstC638720978 11.7 9.92 3.79 up 1.51E-‐03 RRSL_02197 o c Hypothetical Protein638720979 10.67 8.34 5.55 up 4.01E-‐04 RRSL_02198 o c DnaK suppressor protein638720980 11.63 9.67 4.32 up 1.31E-‐03 RRSL_02199 o c Hypothetical Protein638720981 14.01 11.53 6.16 up 6.99E-‐04 RRSL_02200 o c Hypothetical Protein638720982 9.44 8.28 2.47 up 1.87E-‐02 RRSL_02201 o c Alcohol dehydrogenase( EC:1.1.1.1 )638720983 11.43 7.95 12.26 up 1.11E-‐03 RRSL_02202 o c Hypothetical Protein638720984 11.8 10.2 3.34 up 9.13E-‐04 RRSL_02203 o Hypothetical membrane spanning protein638720985 12.08 10.81 2.65 up 1.15E-‐02 RRSL_02204 o c Hypothetical Protein638720986 14.33 12.75 3.3 up 8.33E-‐04 RRSL_02205 o c Hypothetical Protein638720996 11.37 10.43 2.11 up 1.23E-‐02 RRSL_02215 o Hypothetical Protein638721008 10.68 9.65 2.26 up 1.10E-‐02 RRSL_02228 o Hypothetical Protein638720507 9.41 7.88 3.18 up 4.35E-‐03 RRSL_02246 o 3-‐hydroxyisobutyrate dehydrogenase( EC:1.1.1.31 )638720508 10.28 8.6 3.53 up 6.00E-‐03 RRSL_02247 o malonate-‐semialdehyde dehydrogenase [acylating] / methylmalonate-‐semialdehyde dehydrogenase (acylating)( EC:1.2.1.18,EC:1.2.1.27 )638720514 10.45 9.22 2.58 up 3.97E-‐02 RRSL_02253 o c Transmembrane transport protein. Major facilitator superfamily.638720524 9.53 8.33 2.53 up 2.62E-‐02 RRSL_02264 o Leucine-‐rich repeat family protein638720528 11.5 9.63 4.04 up 5.10E-‐03 RRSL_02268 o 5-‐methyltetrahydropteroyltriglutamate-‐-‐ homocysteine methyltransferase( EC:2.1.1.14 )638720813 8.99 7.1 4.07 up 1.83E-‐02 RRSL_02294 Hypothetical Protein638720814 11.47 8.85 6.78 up 4.32E-‐03 RRSL_02295 o Hypothetical Protein638720815 10.21 7.65 6.54 up 1.11E-‐03 RRSL_02296 o Hypothetical Protein638720816 9.36 8.14 2.58 up 2.16E-‐02 RRSL_02297 o Hypothetical Protein638720819 11.03 8.96 4.62 up 1.63E-‐02 RRSL_02300 o c Hypothetical Protein638720830 9.7 8.37 2.77 up 1.03E-‐02 RRSL_02311 o c fliH FliH638720831 9.32 8.07 2.62 up 1.27E-‐02 RRSL_02312 o c fliG FliG638720833 9.29 8.13 2.46 up 5.70E-‐03 RRSL_02314 o c fliE FliE638720834 10.23 8.53 3.57 up 1.14E-‐02 RRSL_02315 o c Hypothetical protein638720837 10.92 7.89 9.01 up 3.87E-‐03 RRSL_02318 o fliT FliT638720838 8.94 7.3 3.45 up 1.98E-‐02 RRSL_02319 o fliS FliS638720839 9.76 8.37 2.89 up 8.65E-‐03 RRSL_02320 o fliD FliD638720840 14.9 12.39 6.27 up 3.01E-‐03 RRSL_02321 o fliC FliC638720843 10.15 8.81 2.8 up 8.86E-‐03 RRSL_02324 o c fliL FliL638720846 9.66 8.47 2.51 up 4.18E-‐02 RRSL_02327 o c fliO FliO638720847 8.64 7.56 2.33 up 2.94E-‐02 RRSL_02328 o c fliP FliP638720848 9.82 8.39 2.97 up 9.48E-‐03 RRSL_02329 o c fliQ FliQ638720851 8.66 7.78 2.04 up 2.43E-‐02 RRSL_02334 o c flgL FlgL638720853 10.83 9.67 2.46 up 2.28E-‐02 RRSL_02336 o c flgJ FlgJ638720854 9.48 8.38 2.37 up 2.37E-‐02 RRSL_02337 o c flgI FlgI638720856 11.29 10.36 2.09 up 3.14E-‐02 RRSL_02339 o c flgG FlgG638720859 11.84 10.95 2.04 up 1.18E-‐02 RRSL_02342 o c flgD FlgD638720860 10.34 9.01 2.78 up 1.17E-‐02 RRSL_02343 o c flgC FlgC638720873 10.5 9.22 2.68 up 4.45E-‐02 RRSL_02356 Hypothetical Protein638720877 10.74 9.18 3.25 up 1.86E-‐03 RRSL_02362 o Cytochrome c oxidase polypeptide I( EC:1.9.3.1 )638720897 10.97 7.53 11.96 up 2.39E-‐02 RRSL_02385 o c Transcriptional regulators, LysR family638720907 12.91 11.81 2.36 up 2.26E-‐02 RRSL_02395 o c Hypothetical Protein638721048 13.17 9.07 18.88 up 8.54E-‐05 RRSL_02441 o popC PopC638721047 12.75 7.95 30.67 up 3.44E-‐04 RRSL_02442 o c popB PopB638721046 14.85 8.22 109.1 up 5.69E-‐06 RRSL_02443 o popA PopA638721252 15.17 14.27 2.05 up 2.34E-‐02 RRSL_02458 o c Transmembrane LysE-‐type efflux permease638721190 12.86 11.35 3.15 up 8.69E-‐04 RRSL_02516 o hypothetical protein638721193 12.09 10.13 4.28 up 1.10E-‐04 RRSL_02518 o c hypothetical protein638721205 14.38 13.17 2.55 up 2.24E-‐03 RRSL_02532 o c Catalase( EC:1.11.1.6 )638721220 12.6 11.45 2.43 up 2.65E-‐02 RRSL_02549 o hypothetical protein638720030 10.76 9.87 2.05 up 3.14E-‐03 RRSL_02642 o c marC MarC638719996 12.16 10.49 3.5 up 1.08E-‐03 RRSL_02682 o c Pectate lyase( EC:4.2.2.2 )638720697 11.98 9.24 7.38 up 2.49E-‐02 RRSL_02730 o c Hypothetical Protein638720699 9.01 8.06 2.13 up 7.13E-‐03 RRSL_02732 o c Hypothetical Protein638720739 12.13 9.95 5 up 2.10E-‐03 RRSL_02771 o c Iron(III)-‐binding protein638720740 11.38 8.94 5.97 up 5.93E-‐04 RRSL_02772 o c sfuB SfuB638720741 11.51 9.52 4.39 up 1.13E-‐03 RRSL_02773 o c sfuC SfuC638720610 13.1 12 2.37 up 1.09E-‐02 RRSL_02785 o c Integral membrane protein638720611 12 11.11 2.04 up 2.14E-‐02 RRSL_02786 o Hypothetical Protein638720613 12.63 10.47 4.93 up 3.50E-‐02 RRSL_02788 o c fucose/mannose-‐binding lectin638720614 11.88 9.42 6.07 up 1.46E-‐02 RRSL_02789 aidA AidA638720615 10.14 8.96 2.49 up 1.72E-‐02 RRSL_02790 Hypothetical protein638720619 12.28 8 21.45 up 1.14E-‐03 RRSL_02794 o c Coproporphyrinogen oxidase, anaerobic( EC:1.-‐ )638720629 10.32 8.99 2.79 up 4.00E-‐02 RRSL_02805 o c Transcriptional regulator, GntR family638720630 10.31 7.83 6.16 up 4.99E-‐02 RRSL_02806 o c C4-‐dicarboxylate transport protein638720634 9.9 8.84 2.29 up 6.23E-‐04 RRSL_02810 o c Hypothetical Protein638720636 11.14 8.88 5.29 up 2.87E-‐03 RRSL_02812 o c Hypothetical Protein638720662 8.69 7.48 2.55 up 2.54E-‐03 RRSL_02842 livH LivH638720663 10.36 9.33 2.25 up 9.43E-‐03 RRSL_02843 o conserved hypothetical protein638720548 10.36 8.16 5.07 up 7.00E-‐04 RRSL_02858 hypothetical protein638720549 9.57 7.25 5.48 up 1.75E-‐03 RRSL_02859 Acyl-‐CoA dehydrogenase, short-‐chain specific( EC:1.3.99.2 )

638720550 12.25 9.69 6.52 up 5.98E-‐06 RRSL_02860 hypothetical protein638720551 9.99 8.24 3.73 up 3.25E-‐03 RRSL_02861 hypothetical protein638720552 10.43 8.28 4.9 up 2.58E-‐04 RRSL_02862 hypothetical protein638720553 11.36 9.09 5.34 up 9.65E-‐04 RRSL_02863 Polyketide synthase638720554 11.48 9.84 3.45 up 6.19E-‐04 RRSL_02864 Thioesterase( EC:3.1.2.-‐ )638720589 8.85 7.47 2.87 up 1.21E-‐02 RRSL_02903 o c hypothetical protein638720591 11.43 9.11 5.51 up 7.47E-‐03 RRSL_02905 o c hypothetical protein638720592 9.53 8.52 2.22 up 1.06E-‐02 RRSL_02906 o c hypothetical protein638720609 10.56 9.12 2.99 up 4.54E-‐03 RRSL_02925 hypothetical protein638720381 9.87 8.95 2.09 up 1.24E-‐02 RRSL_02962 o c 4-‐aminobutyrate aminotransferase( EC:2.6.1.19 )638720383 10.35 9.17 2.49 up 9.63E-‐03 RRSL_02964 Hypothetical Protein638720384 9.74 8.44 2.72 up 8.69E-‐03 RRSL_02965 Hypothetical Protein638720385 11.62 10.22 2.91 up 1.86E-‐03 RRSL_02966 Phospholipase C( EC:3.1.4.3 )638720291 11.46 10.16 2.72 up 1.95E-‐03 RRSL_03035 o c HdeD protein638720319 12.28 9.67 6.75 up 8.23E-‐05 RRSL_03065 o Hypothetical Protein638720321 12.05 11.14 2.07 up 3.33E-‐02 RRSL_03067 o c Hypothetical Protein638720322 9.88 8.34 3.21 up 2.09E-‐02 RRSL_03068 o c Hypothetical Protein638720333 14.57 13.7 2.02 up 1.94E-‐02 RRSL_03080 Hypothetical Protein638721036 10.58 8.6 4.36 up 1.45E-‐03 RRSL_03105 o conserved hypothetical protein638721035 10.35 8.82 3.2 up 5.67E-‐03 RRSL_03106 o pglA PglA( EC:3.2.1.15 )638721029 8.95 7.79 2.47 up 1.15E-‐02 RRSL_03113 o c Hypothetical Protein638721028 9.49 7.28 5.12 up 9.28E-‐04 RRSL_03114 o glnA GlnA( EC:6.3.1.2 )638721026 10.46 8.76 3.58 up 9.64E-‐03 RRSL_03117 o 2-‐amino-‐3-‐ketobutyrate coenzyme A ligase( EC:2.3.1.29 )638720435 9.04 7.43 3.36 up 7.90E-‐03 RRSL_03197 o c Imidazolonepropionase( EC:3.5.2.7 )638720437 12.18 9.71 6.08 up 3.39E-‐03 RRSL_03199 o c Histidine ammonia-‐lyase( EC:4.3.1.3 )638720438 11.8 10.07 3.68 up 4.22E-‐03 RRSL_03200 o c Urocanate hydratase( EC:4.2.1.49 )638720475 10.41 8.86 3.22 up 9.08E-‐04 RRSL_03241 o c Hypothetical Protein638720477 9.98 8.62 2.85 up 9.58E-‐03 RRSL_03243 o Hypothetical Protein638720478 15.1 14.01 2.35 up 2.93E-‐03 RRSL_03244 Hypothetical Protein638720204 11.68 10.13 3.24 up 2.12E-‐02 RRSL_03366 o c Omega-‐amino acid-‐-‐pyruvate aminotransferase( EC:2.6.1.18 )638720209 12.6 9.3 10.89 up 1.07E-‐04 RRSL_03371 o c Hypothetical Protein638720210 11.31 8.6 7.24 up 1.82E-‐04 RRSL_03372 o c Ferrichrome-‐iron receptor638720211 12.25 9.35 8.21 up 9.09E-‐04 RRSL_03374 o c Fructokinase( EC:2.7.1.4 )638720212 12.01 8.39 13.63 up 5.26E-‐04 RRSL_03375 o c Hypothetical Protein638720213 10.75 7.62 9.64 up 5.10E-‐03 RRSL_03376 o c Phosphoenolpyruvate-‐protein phosphotransferase / Phosphocarrier protein HPr / PTS system, glucose-‐specific IIA subunit( EC:2.7.1.69,EC:2.7.3.9 )638720214 11.43 7.91 12.65 up 4.16E-‐03 RRSL_03377 o c Maltoporin638720215 12.98 8.18 30.68 up 2.29E-‐04 RRSL_03378 o c Sucrose-‐6-‐phosphate hydrolase( EC:3.2.1.26 )638720216 12.67 8.13 25.55 up 2.00E-‐04 RRSL_03379 o c PTS system, sucrose-‐specific IIBC component( EC:2.7.1.69 )638720217 11.99 9.98 4.46 up 1.37E-‐02 RRSL_03380 o c Transcriptional regulator, LacI family638720250 11.37 9.91 3.03 up 6.86E-‐03 RRSL_03415 Hypothetical Protein638720272 9.05 7.04 4.46 up 8.95E-‐03 RRSL_03438 o Hypothetical Protein638719715 11.51 8.89 6.79 up 3.98E-‐04 RRSL_03499 o c Flavodoxin638719742 9.96 8.86 2.38 up 1.12E-‐02 RRSL_03527 o Hypothetical Protein638719746 10.98 9.15 3.92 up 2.94E-‐02 RRSL_03531 Hypothetical Protein638719861 9.82 8.63 2.53 up 8.25E-‐04 RRSL_03559 o Hypothetical Protein638719862 7.92 6.75 2.49 up 1.58E-‐03 RRSL_03560 Hypothetical Protein638719884 9.53 8.07 3.02 up 2.32E-‐03 RRSL_03583 o c Hypothetical Protein638719885 8.5 7.54 2.14 up 1.59E-‐02 RRSL_03584 o c Chloride channel protein638719886 11.96 9.57 5.79 up 9.05E-‐04 RRSL_03585 o c Transcriptional regulator, MarR family638719887 10.44 8.38 4.59 up 2.69E-‐02 RRSL_03586 Hypothetical Protein638719892 11.73 10.43 2.71 up 4.16E-‐03 RRSL_03590 o c Permease638719894 13.68 12.53 2.45 up 3.20E-‐03 RRSL_03592 o c Oxidoreductase( EC:1.1.1.-‐ )638719932 9.31 8.21 2.36 up 2.39E-‐03 RRSL_03632 o c Formate hydrogenlyase subunit 6638719934 11.56 9.93 3.42 up 7.09E-‐04 RRSL_03634 o c Hypothetical Protein638719935 10.02 8.26 3.74 up 2.46E-‐03 RRSL_03635 o c Formate dehydrogenase (cytochrome b) major subunit( EC:1.2.2.1 )638719936 10.18 8.32 4.01 up 1.91E-‐03 RRSL_03636 o c Formate dehydrogenase (cytochrome b) iron-‐sulfur subunit( EC:1.2.2.1 )638719937 9.37 8.03 2.8 up 1.39E-‐02 RRSL_03637 o c Hypothetical Protein638719938 9.76 8.41 2.81 up 1.68E-‐02 RRSL_03638 o c Formate dehydrogenase, cytochrome B556 subunit( EC:1.2.2.1 )638719939 9.88 8.78 2.38 up 1.31E-‐02 RRSL_03639 o c Hypothetical Protein638719946 9.55 7.71 3.97 up 2.10E-‐02 RRSL_03646 o c Hypothetical Protein638720148 9.11 8.18 2.1 up 7.20E-‐03 RRSL_03669 o c Probable transmembrane methyl-‐accepting chemotaxis protein638720185 13.13 10.21 8.32 up 4.11E-‐04 RRSL_03707 o Vanillate O-‐demethylase oxygenase subunit( EC:1.14.13.82,EC:1.2.3.12 )638720186 9.98 8.53 3.02 up 9.10E-‐03 RRSL_03708 o Vanillate O-‐demethylase oxidoreductase subunit( EC:1.2.3.12 )638720188 12.54 10.33 5.11 up 9.34E-‐04 RRSL_03710 o Hypothetical Protein638720190 8.44 7.57 2 up 6.34E-‐03 RRSL_03712 Hypothetical Protein638720192 8.73 7.53 2.54 up 4.76E-‐02 RRSL_03714 o transkriptions-‐aktivator-‐protein638719453 12.71 11.72 2.18 up 4.80E-‐03 RRSL_03828 Hypothetical Protein638719489 9.94 8.89 2.3 up 4.10E-‐02 RRSL_03869 o c UDP-‐2,3-‐diacylglucosamine hydrolase( EC:3.6.1.-‐ )638719530 8.89 7.96 2.1 up 1.25E-‐02 RRSL_03910 o Nodulation protein N638719539 9.63 7.07 6.49 up 8.05E-‐04 RRSL_03920 Hypothetical Protein638719541 10.07 8.95 2.4 up 7.10E-‐03 RRSL_03922 Hypothetical Protein638719542 13.26 10.58 7.06 up 3.58E-‐04 RRSL_03923 Hypothetical Protein638719562 16.1 14.67 2.96 up 1.51E-‐04 RRSL_03943 o hypothetical protein638719564 13.81 11.86 4.26 up 6.25E-‐05 RRSL_03945 o hypothetical protein638719565 9.58 8.02 3.27 up 2.20E-‐02 RRSL_03946 Pyridoxal-‐dependent aminotransferases638719566 11.26 8.81 6.02 up 2.72E-‐03 RRSL_03947 Pyridoxal-‐dependent aminotransferases

638719567 11.43 7.59 15.84 up 1.77E-‐04 RRSL_03948 o Oxidoreductase ucpA( EC:1.-‐ )638719568 10.33 7.33 8.83 up 1.38E-‐03 RRSL_03949 o Isopenicillin N epimerase( EC:5.-‐ )638719569 9.85 8.15 3.58 up 1.99E-‐02 RRSL_03950 o NADPH-‐dependent glutamate synthase beta chain and related oxidoreductases638719570 10.38 7.77 6.74 up 4.24E-‐03 RRSL_03951 o Tryptophan 2,3-‐dioxygenase( EC:1.13.11.11 )638719571 12.03 8.1 16.81 up 1.20E-‐03 RRSL_03952 hypothetical protein638719573 10.04 8.41 3.4 up 1.36E-‐02 RRSL_03954 hypothetical protein638719585 12.6 11.32 2.68 up 1.36E-‐02 RRSL_03966 o c Transcriptional regulator, MarR family638719588 9.31 8.03 2.67 up 3.03E-‐02 RRSL_03970 o c Probable transmembrane methyl-‐accepting chemotaxis protein638719594 12.04 8.26 15.12 up 3.85E-‐04 RRSL_03976 o c Alcohol dehydrogenase( EC:1.1.1.1 )638719600 10.85 9.64 2.54 up 5.64E-‐03 RRSL_03982 o c Pyruvate-‐flavodoxin oxidoreductase( EC:1.-‐ )638719622 13.24 11.41 3.91 up 1.59E-‐03 RRSL_04004 o c serine protease638719624 10.82 9.36 3.04 up 5.19E-‐03 RRSL_04006 o c hypothetical protein638719232 9.58 8.67 2.08 up 7.68E-‐03 RRSL_04046 Hypothetical Protein638719237 12.03 11.01 2.24 up 2.98E-‐02 RRSL_04052 Hypothetical Protein638719277 12.28 10.96 2.75 up 9.02E-‐04 RRSL_04096 o c Molybdopterin-‐guanine dinucleotide biosynthesis protein B638719278 13.28 11.43 3.98 up 6.00E-‐04 RRSL_04097 o Avirulence D protein638719279 11.18 9.81 2.84 up 6.49E-‐04 RRSL_04098 o Phosphoglycolate phosphatase( EC:3.1.3.18 )638719308 8.72 7.47 2.63 up 1.95E-‐02 RRSL_04128 o c Hypothetical Protein638719309 12.81 10.95 4 up 5.26E-‐04 RRSL_04129 o c Transporter638719311 11.38 9.28 4.74 up 3.23E-‐02 RRSL_04130 o Hypothetical Protein638719332 8.42 7.55 2.03 up 6.97E-‐03 RRSL_04156 o c Apolipoprotein N-‐acyltransferase( EC:2.3.1.-‐ )638719344 11.1 9.5 3.36 up 1.39E-‐04 RRSL_04169 o c Outer membrane porin protein 32 precursor638719349 10.57 9.24 2.77 up 3.18E-‐02 RRSL_04174 o c Hypothetical Protein638719352 11.9 8.64 10.55 up 2.43E-‐03 RRSL_04177 o c Flavohemoprotein / Dihydropteridine reductase / Nitric oxide dioxygenase( EC:1.14.12.17,EC:1.6.99.7 )638719353 12.16 9.61 6.45 up 4.43E-‐03 RRSL_04178 Hypothetical protein638719354 10.97 9.51 3.03 up 2.91E-‐03 RRSL_04180 o c Probable transmembrane transporter, MFS family638719367 9.51 8.33 2.51 up 4.54E-‐02 RRSL_04193 o c Probable transmembrane methyl-‐accepting chemotaxis protein638719369 11.54 10.3 2.61 up 3.51E-‐03 RRSL_04195 o c Hypothetical membrane spanning protein638719157 10.41 9.33 2.34 up 1.01E-‐02 RRSL_04307 o c HlyD family secretion protein638719173 9.37 8.17 2.54 up 4.82E-‐02 RRSL_04324 o c Transposase638719173 9.37 8.17 2.54 up 4.82E-‐02 RRSL_04324 o c Transposase638719173 9.37 8.17 2.54 up 4.82E-‐02 RRSL_04324 o c Transposase638719173 9.37 8.17 2.54 up 4.82E-‐02 RRSL_04324 o c Transposase638719173 9.37 8.17 2.54 up 4.82E-‐02 RRSL_04324 o Transposase638719173 9.37 8.17 2.54 up 4.82E-‐02 RRSL_04324 o Transposase638719173 9.37 8.17 2.54 up 4.82E-‐02 RRSL_04324 o Transposase638719173 9.37 8.17 2.54 up 4.82E-‐02 RRSL_04324 o Transposase638719205 11.29 9.65 3.45 up 1.03E-‐02 RRSL_04358 o c Enoyl-‐[acyl-‐carrier protein] reductase (NADH)( EC:1.3.1.9 )638719230 13.79 10.73 9.16 up 2.59E-‐04 RRSL_04386 o c Hypothetical Protein638718935 10.26 8.47 3.8 up 4.17E-‐02 RRSL_04390 o c rbsC RbsC638718945 12.72 10.8 4.2 up 8.38E-‐04 RRSL_04400 o c Carboxypeptidase S1( EC:3.4.16.6 )638718951 11.09 10.18 2.07 up 6.22E-‐03 RRSL_04407 o c hypothetical protein638718976 15.34 14.24 2.37 up 3.31E-‐03 RRSL_04432 o c hypothetical protein638718990 12.33 11.08 2.62 up 1.35E-‐02 RRSL_04448 o c hypothetical protein638719012 9.79 7.46 5.53 up 2.36E-‐02 RRSL_04471 o probable transmembrane protein638719068 9.7 8.36 2.8 up 1.40E-‐02 RRSL_04529 o c hypothetical protein638719086 11.8 8.99 7.76 up 1.76E-‐03 RRSL_04547 o probable conserved hypothetical protein638719087 14.85 11.74 9.57 up 6.82E-‐06 RRSL_04548 o c hypothetical protein638719109 9.83 8.32 3.13 up 1.64E-‐03 RRSL_04571 o c Alkyl hydroperoxide reductase C22( EC:1.6.4.-‐ )638718740 11.32 9.82 3.12 up 1.17E-‐02 RRSL_04591 Hypothetical Protein638718743 9.74 7.88 4.01 up 1.29E-‐02 RRSL_04594 o Asparagine synthetase (glutamine-‐hydrolyzing)( EC:6.3.5.4 )638718745 12.58 10.8 3.8 up 1.82E-‐03 RRSL_04596 o Hypothetical Protein638718746 12.48 9.02 12.15 up 2.76E-‐04 RRSL_04597 o Nitrate/nitrite sensor protein narX( EC:2.7.3.-‐ )638718747 10.09 7.99 4.72 up 1.94E-‐02 RRSL_04598 o Molybdopterin-‐guanine dinucleotide biosynthesis protein B638718748 12.66 8.33 22.26 up 7.01E-‐04 RRSL_04599 o Respiratory nitrate reductase gamma chain( EC:1.7.99.4 )638718749 10.43 7.69 7.4 up 6.21E-‐03 RRSL_04600 o Respiratory nitrate reductase delta chain( EC:1.7.99.4 )638718750 10.4 7.88 6.35 up 1.10E-‐02 RRSL_04601 Respiratory nitrate reductase beta chain( EC:1.7.99.4 )638718751 13.24 9.4 15.78 up 1.56E-‐03 RRSL_04602 Hypothetical Protein638718752 11.7 8.95 7.44 up 7.29E-‐03 RRSL_04603 o Respiratory nitrate reductase alpha chain( EC:1.7.99.4 )638718754 8.7 7.43 2.68 up 4.29E-‐02 RRSL_04605 Hypothetical Protein638718755 11.58 9.1 6.11 up 1.90E-‐03 RRSL_04606 o Nitrite extrusion protein638718756 9.56 7.71 3.98 up 7.15E-‐03 RRSL_04607 o Nitrite extrusion protein638718757 12.16 8.95 10.21 up 4.37E-‐04 RRSL_04608 o Anaerobic ribonucleoside-‐triphosphate reductase( EC:1.17.4.2 )638718758 10.36 7.76 6.7 up 1.86E-‐03 RRSL_04609 o Pyruvate formate-‐lyase activating enzyme( EC:1.97.1.4 )638718759 9.71 7.09 6.77 up 2.72E-‐03 RRSL_04610 o Hypothetical Protein638718760 9.52 7.47 4.57 up 2.98E-‐03 RRSL_04611 o Hypothetical Protein638718761 9.94 7.36 6.59 up 7.43E-‐04 RRSL_04612 o sterol binding protein638718762 10.16 7.64 6.34 up 3.12E-‐03 RRSL_04613 o Putative protease yhbV precursor( EC:3.4.-‐ )638718763 10.99 8.31 7.08 up 9.98E-‐04 RRSL_04614 o Putative protease yhbU precursor( EC:3.4.-‐ )638718768 9.93 8.85 2.34 up 3.28E-‐02 RRSL_04619 o Hypothetical protein638718769 12.97 11.88 2.36 up 3.03E-‐03 RRSL_04620 Hypothetical Protein638718770 11 9.44 3.23 up 1.13E-‐02 RRSL_04621 o Hypothetical Protein638718781 10.42 9.5 2.09 up 1.25E-‐02 RRSL_04632 o Hypothetical Protein638718793 10.76 9.78 2.17 up 1.13E-‐02 RRSL_04644 Hypothetical Protein638718794 13.33 12.38 2.13 up 9.56E-‐03 RRSL_04645 Catalase( EC:1.11.1.6 )638718804 8.94 7.95 2.19 up 1.15E-‐02 RRSL_04655 o Hypothetical Protein

638718809 9.95 8.3 3.46 up 2.17E-‐03 RRSL_04660 Hypothetical Protein638718808 9.7 7.87 3.9 up 4.33E-‐02 RRSL_04661 Hypothetical Protein638718810 10.26 9.2 2.3 up 3.28E-‐02 RRSL_04662 o c Cardiolipin synthetase( EC:2.7.8.-‐ )638718814 12.68 10.89 3.82 up 3.23E-‐04 RRSL_04666 o Cyanide-‐insensitive cytochrome bd-‐type quinol oxidase subunit I( EC:1.10.3.-‐ )638718815 10.55 8.24 5.5 up 3.47E-‐03 RRSL_04667 o Cyanide-‐insensitive cytochrome bd-‐type quinol oxidase subunit II( EC:1.10.3.-‐ )638718818 10.61 9.53 2.33 up 9.95E-‐03 RRSL_04670 o Hypothetical Protein638718853 13.37 12.33 2.26 up 5.36E-‐03 RRSL_04709 o c Hypothetical cytosolic protein638718855 9.21 7.7 3.15 up 2.33E-‐02 RRSL_04711 o c Methylamine utilization protein mauG precursor638718868 12.35 10.88 3.06 up 4.70E-‐02 RRSL_04724 Hypothetical Protein638718871 9.57 8.27 2.71 up 1.33E-‐02 RRSL_04728 o c Hypothetical Protein638718877 11.47 9.6 4.04 up 7.28E-‐03 RRSL_04734 o c Hypothetical Protein638718906 9.24 8.07 2.48 up 2.70E-‐02 RRSL_04764 Hypothetical Protein638718907 8.34 7.43 2.08 up 1.57E-‐02 RRSL_04765 o c Cytochrome O ubiquinol oxidase subunit III( EC:1.10.3.-‐ )638718908 8.99 8.02 2.16 up 2.83E-‐03 RRSL_04767 o c Cytochrome c oxidase polypeptide I( EC:1.9.3.1 )638718909 9.06 7.78 2.68 up 8.26E-‐03 RRSL_04768 o c Hypothetical Protein( EC:1.9.3.1 )638718918 13.39 8.82 26.18 up 6.27E-‐04 RRSL_04777 o c Nodulation protein NOLX638718926 15.99 13.72 5.33 up 1.84E-‐04 RRSL_04787 o c Hypothetical Protein638718931 11.1 10.19 2.08 up 1.35E-‐02 RRSL_04792 o c Hypothetical Protein638721050 11.73 7.95 15.18 up 5.68E-‐04 RRSL_10003 o c hrpB HrpB638719377 12.17 11.19 2.18 up 1.47E-‐02 RRSL_RNA038 ( tRNA )638723098 10.73 12.01 2.19 down 5.73E-‐03 RRSL_00076 o c Undecaprenyl-‐phosphate alpha-‐4-‐amino-‐L-‐arabinosyltransferase( EC:2.7.8.-‐ )638723100 6.9 8.27 2.35 down 2.59E-‐03 RRSL_00078 UDP-‐4-‐amino-‐4-‐deoxy-‐L-‐arabinose N-‐formyltransferase( EC:2.1.2.-‐ )638723111 11.24 12.67 2.44 down 6.33E-‐03 RRSL_00083 o c TolQ protein638723112 8.19 9.93 3.04 down 2.48E-‐03 RRSL_00084 o c TolR protein638723110 12.68 13.91 2.13 down 1.54E-‐02 RRSL_00103 o c Hypothetical Protein638723088 11.25 13.45 4.17 down 9.67E-‐05 RRSL_00106 o c Ferredoxin638723077 11.03 12.25 2.11 down 1.13E-‐02 RRSL_00114 o c PhnA protein638723066 11.55 12.92 2.34 down 1.29E-‐02 RRSL_00139 o c Low-‐affinity inorganic phosphate transporter638723067 12.71 14.07 2.32 down 1.82E-‐03 RRSL_00140 o c Putative pit accessory protein638723059 10.79 12.1 2.25 down 1.04E-‐02 RRSL_00147 o c Glutamyl-‐tRNA synthetase( EC:6.1.1.17 )638723047 10.19 12.8 5.51 down 2.22E-‐04 RRSL_00149 o c Glycerol-‐3-‐phosphate regulon repressor638723048 9.62 12.61 7.2 down 9.61E-‐04 RRSL_00150 o c Glycerol-‐3-‐phosphate dehydrogenase( EC:1.1.99.5 )638723049 9.57 11.85 4.41 down 2.44E-‐04 RRSL_00152 o Glycerol transport ATP-‐binding protein638723050 10.98 13.18 4.17 down 4.32E-‐03 RRSL_00153 o Glycerol transport system permease protein638723051 11.3 13.2 3.38 down 1.44E-‐02 RRSL_00154 o Hypothetical Protein638723052 8.83 11.15 4.51 down 1.33E-‐03 RRSL_00155 o Glycerol ABC transporter-‐associated membrane protein638723053 10.79 13.07 4.41 down 8.80E-‐05 RRSL_00156 o Glycerol-‐binding protein638722991 9.01 10.29 2.2 down 1.23E-‐03 RRSL_00182 o c Hypothetical Protein638723041 11.15 12.91 3.09 down 3.39E-‐03 RRSL_00204 Dihydrolipoamide succinyltransferase component (E2) of 2-‐oxoglutarate dehydrogenase complex( EC:2.3.1.61 )638723021 12.36 13.55 2.05 down 3.00E-‐02 RRSL_00208 o c Integration host factor beta-‐subunit638723027 9.67 10.88 2.09 down 9.17E-‐03 RRSL_00214 o c COME operon protein 1638723030 8.76 9.95 2.07 down 3.05E-‐02 RRSL_00216 o c Acetylspermidine deacetylase( EC:3.5.1.48 )638722955 9.89 11.38 2.55 down 2.60E-‐02 RRSL_00226 o c Acyl-‐[acyl-‐carrier-‐protein]-‐-‐UDP-‐N-‐ acetylglucosamine O-‐acyltransferase( EC:2.3.1.129 )638722971 13.12 14.76 2.83 down 4.34E-‐02 RRSL_00246 o c Hypothetical Protein638722981 10.9 12.19 2.22 down 5.50E-‐03 RRSL_00266 o c ATP-‐dependent protease subunit638722982 9.61 11.46 3.27 down 6.24E-‐03 RRSL_00267 o c Glutamate N-‐acetyltransferase / Amino-‐acid acetyltransferase( EC:2.3.1.1,EC:2.3.1.35 )638722983 11.45 12.7 2.15 down 3.29E-‐02 RRSL_00268 o c Protein translocase subunit secA638722931 8.66 10.24 2.71 down 4.48E-‐02 RRSL_00303 o c DNA polymerase III subunit gamma/tau( EC:2.7.7.7 )638722933 9.55 10.88 2.28 down 4.67E-‐02 RRSL_00305 Hypothetical protein638722907 9.76 11.07 2.25 down 4.27E-‐02 RRSL_00314 Tryptophan synthase beta chain( EC:4.2.1.20 )638722948 10.78 11.95 2.04 down 3.63E-‐02 RRSL_00341 o c oxidoreductase, L-‐aspartate oxidase, nadB2( EC:1.4.3.16 )638722814 7.73 9.86 3.97 down 2.40E-‐03 RRSL_00412 o c conserved hypothetical protein638722815 9.77 11.86 3.85 down 5.58E-‐03 RRSL_00413 o c Hypothetical membrane spanning protein638722816 11.56 13.63 3.81 down 2.57E-‐04 RRSL_00414 o c lipoprotein LemA638722761 9.74 11.24 2.56 down 1.61E-‐02 RRSL_00427 o c Hypothetical Protein638722600 8.46 9.75 2.21 down 2.85E-‐03 RRSL_00444 o Transporter, drug/metabolite exporter family638722607 7.82 9.34 2.59 down 2.36E-‐03 RRSL_00452 o Hypothetical Protein638722679 10.23 11.57 2.3 down 2.26E-‐02 RRSL_00549 pilZ PilZ638722855 10.07 11.22 2.01 down 9.62E-‐04 RRSL_00558 o c Hypothetical Protein638722856 7.97 9.28 2.25 down 7.08E-‐03 RRSL_00559 o c Rrf2 family protein638722857 7.98 9.43 2.47 down 5.92E-‐03 RRSL_00560 o c putative nucleoside-‐diphosphate-‐sugar epimerases638722858 8.6 9.76 2.03 down 1.45E-‐02 RRSL_00562 o c Hypothetical Protein638722859 11.42 12.91 2.56 down 1.82E-‐03 RRSL_00563 o c Transcriptional regulatory protein638722867 10.12 11.34 2.1 down 1.85E-‐02 RRSL_00615 o c Hypothetical Protein638722868 12.43 13.86 2.45 down 6.88E-‐03 RRSL_00616 o c UTP-‐-‐glucose-‐1-‐phosphate uridylyltransferase( EC:2.7.7.9 )638722552 9.78 11.06 2.19 down 2.65E-‐02 RRSL_00658 o c DNA polymerase III, epsilon chain( EC:2.7.7.7 )638722558 11.67 13.54 3.3 down 6.52E-‐03 RRSL_00664 o c Hypothetical protein638719950 11.74 13.35 2.76 down 9.42E-‐03 RRSL_00716 o c Protein translocase subunit secD638719952 13.58 15.85 4.38 down 1.04E-‐03 RRSL_00718 o c Hypothetical exported protein638719953 11.89 14.41 5.21 down 2.48E-‐03 RRSL_00719 o c Hypothetical Protein638719954 8.49 11.81 9.06 down 2.46E-‐04 RRSL_00720 o c Cytochrome b561638719958 8.9 10.6 2.96 down 2.18E-‐03 RRSL_00725 o c Phosphohydrolase (MutT/nudix family protein)638719963 9.04 10.48 2.44 down 6.32E-‐03 RRSL_00729 o c Ferrichrome-‐iron receptor638722682 9.42 12.26 6.49 down 6.12E-‐03 RRSL_00744 Porin638722683 9.45 11.01 2.67 down 2.13E-‐02 RRSL_00745 o Hypothetical Protein638722339 8.9 10.15 2.15 down 5.81E-‐03 RRSL_00815 o c Formate dehydrogenase alpha subunit homolog

638722340 10.13 11.4 2.19 down 2.05E-‐02 RRSL_00816 o c Oxalate/formate antiporter638722356 10.15 11.37 2.12 down 2.67E-‐03 RRSL_00833 Hypothetical Protein638722657 13.39 14.81 2.42 down 1.68E-‐02 RRSL_00862 o c DNA-‐binding protein HU638722528 9.08 10.36 2.2 down 1.21E-‐02 RRSL_00868 o c ATP-‐dependent DNA helicase recQ( EC:3.6.1.-‐ )638722535 8.78 10.2 2.42 down 5.51E-‐04 RRSL_00875 o c Hypothetical Protein638722536 12.55 13.82 2.19 down 4.79E-‐02 RRSL_00876 o c DNA-‐directed RNA polymerase beta chain( EC:2.7.7.6 )638722454 8.59 9.99 2.4 down 5.12E-‐03 RRSL_00903 o Maleylpyruvate isomerase( EC:5.2.1.2,EC:5.2.1.4 )638722304 12.16 14.36 4.18 down 2.89E-‐04 RRSL_00920 o Molybdopterin-‐guanine dinucleotide biosynthesis protein A638722305 9.03 12.65 11.16 down 3.57E-‐04 RRSL_00921 o Hypothetical Protein638722320 8.12 9.78 2.86 down 9.08E-‐04 RRSL_00937 o mexC MexC638722324 10.25 11.52 2.18 down 2.65E-‐02 RRSL_00941 Hypothetical Protein638722379 11.97 13.14 2.05 down 5.60E-‐03 RRSL_00971 o c Inorganic pyrophosphatase( EC:3.6.1.1 )638722383 11.48 13.83 4.61 down 1.11E-‐03 RRSL_00975 o c hydrogenase cytochrome B-‐type subunit homolog638722386 9.92 11.7 3.11 down 1.90E-‐03 RRSL_00977 o c Phosphoenolpyruvate carboxylase( EC:4.1.1.31 )638722385 7.78 8.98 2.08 down 2.01E-‐02 RRSL_00978 o c UROPORPHYRINOGEN-‐III SYNTHASE / Uroporphyrin-‐III C-‐methyltransferase( EC:2.1.1.107,EC:4.2.1.75 )638722508 10.8 12.28 2.52 down 2.25E-‐03 RRSL_00994 o c phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase( EC:2.1.2.3,EC:3.5.4.10 )638722520 10.18 11.54 2.32 down 1.63E-‐02 RRSL_01007 o c Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638722521 8.8 10.05 2.16 down 4.82E-‐03 RRSL_01008 o c 4-‐hydroxythreonine-‐4-‐phosphate dehydrogenase( EC:1.1.1.262 )638722299 10.28 11.6 2.27 down 1.36E-‐02 RRSL_01110 o c amiC AmiC( EC:3.5.1.28 )638721635 8.48 9.8 2.26 down 8.38E-‐03 RRSL_01150 o c Holo-‐[acyl-‐carrier protein] synthase( EC:2.7.8.7 )638721636 9.7 10.9 2.09 down 4.94E-‐02 RRSL_01151 o c pdxJ PdxJ638721650 11.86 13.42 2.68 down 2.28E-‐02 RRSL_01167 o c Malonyl-‐CoA-‐[acyl-‐carrier-‐protein] transacylase( EC:2.3.1.39 )638721651 11.91 13.14 2.12 down 3.72E-‐02 RRSL_01168 o c 3-‐oxoacyl-‐[acyl-‐carrier-‐protein] synthase III( EC:2.3.1.41 )638721652 12.04 13.3 2.16 down 1.21E-‐02 RRSL_01169 o c plsX PlsX638721655 11.13 12.49 2.33 down 2.00E-‐04 RRSL_01172 o c Septum formation protein Maf638721656 8.67 10.05 2.36 down 1.81E-‐04 RRSL_01173 o c Methyltransferase( EC:2.1.1.-‐ )638721669 8.15 9.5 2.32 down 2.60E-‐03 RRSL_01187 o c Hypothetical protein638721671 10.47 11.95 2.54 down 4.32E-‐03 RRSL_01189 o c Bacterial Peptide Chain Release Factor 2 (RF-‐2)638721672 8.35 10.49 3.98 down 3.35E-‐03 RRSL_01190 Hypothetical Protein638721673 8.19 9.93 3.02 down 7.23E-‐03 RRSL_01191 o c Sepiapterin reductase( EC:1.1.1.153 )638722123 9.52 10.72 2.08 down 1.59E-‐02 RRSL_01208 Hypothetical Protein638722130 13.13 14.45 2.27 down 9.99E-‐03 RRSL_01215 o c Argininosuccinate synthase argG( EC:6.3.4.5 )638722133 12.07 13.74 2.88 down 2.68E-‐02 RRSL_01218 o c Hypothetical Protein638722149 11.38 12.67 2.22 down 6.12E-‐03 RRSL_01235 o c Phosphoribosylformylglycinamidine cyclo-‐ligase( EC:6.3.3.1 )638722151 9.03 10.28 2.16 down 1.10E-‐03 RRSL_01237 o c DnaA-‐related protein638722153 9.76 10.94 2.06 down 3.30E-‐02 RRSL_01239 o c poly(a) polymerase / tRNA nucleotidyltransferase( EC:2.7.7.19,EC:2.7.7.25 )638722160 10.57 12.14 2.69 down 2.67E-‐03 RRSL_01246 dnaJ DnaJ638722161 9.95 11.92 3.55 down 8.66E-‐04 RRSL_01247 Chaperone protein dnaJ638722057 8.16 9.45 2.23 down 2.30E-‐04 RRSL_01254 o c Xanthine dehydrogenase large subunit( EC:1.1.1.204 )638722059 8.76 9.92 2.03 down 1.58E-‐02 RRSL_01256 o c Adenosine deaminase( EC:3.5.4.4 )638722067 9.77 11.01 2.14 down 1.55E-‐03 RRSL_01265 o Dehydrogenase protein DltE638722078 12.07 13.3 2.13 down 4.07E-‐02 RRSL_01276 o c NADP-‐dependent malic enzyme( EC:1.1.1.40 )638722080 9.86 11.81 3.5 down 8.53E-‐03 RRSL_01279 o c aminopeptidase N (alpha-‐aminoacyl peptide hydrolase) metalloprotease; pepN( EC:3.4.11.2 )638722081 11.9 13.11 2.11 down 1.35E-‐02 RRSL_01280 o c Fructose-‐1,6-‐bisphosphatase( EC:3.1.3.11 )638722235 7.95 9.36 2.41 down 2.64E-‐03 RRSL_01320 o c Signal peptidase I( EC:3.4.21.89 )638721994 10.18 11.42 2.14 down 2.07E-‐03 RRSL_01322 o c Protein Translation Elongation Factor Ts (EF-‐Ts)638722005 10.5 11.97 2.51 down 7.71E-‐03 RRSL_01334 o c dapC DapC( EC:2.6.1.17 )638722011 9.71 11.02 2.25 down 2.57E-‐04 RRSL_01342 Membrane-‐fusion protein (Cell envelope biogenesis, outer membrane)638722013 8.09 9.8 2.98 down 1.13E-‐03 RRSL_01344 o c Hypothetical Protein638722014 7.44 8.67 2.13 down 7.85E-‐03 RRSL_01345 o c D-‐aminopeptidase( EC:3.4.11.19 )638722015 9.49 11.19 2.96 down 3.53E-‐04 RRSL_01346 o c D-‐aminopeptidase( EC:3.4.11.19 )638722016 9.69 10.97 2.2 down 1.40E-‐02 RRSL_01347 o c dppC DppC638722018 10.33 12.23 3.38 down 2.13E-‐03 RRSL_01349 o c Dipeptide-‐binding protein638722019 8.12 9.99 3.31 down 2.03E-‐03 RRSL_01350 o c dppF DppF638722020 8.41 10.2 3.13 down 7.72E-‐04 RRSL_01351 o c L-‐asparaginase( EC:3.5.1.1 )638722021 9.26 10.67 2.41 down 2.30E-‐02 RRSL_01352 o c Transcriptional regulator, RpiR family638721904 8.72 10.41 2.91 down 1.58E-‐02 RRSL_01364 Molybdopterin biosynthesis MoeB protein638721905 10.43 12.25 3.21 down 3.26E-‐02 RRSL_01365 MEC+638721906 9.07 10.94 3.3 down 1.73E-‐02 RRSL_01366 ThiS family protein638721908 8.3 10.01 2.97 down 1.10E-‐02 RRSL_01368 2,3-‐dihydroxybenzoate-‐AMP ligase( EC:2.7.7.58 )638721911 9.71 11.08 2.35 down 2.85E-‐02 RRSL_01371 Unsaturated glucuronyl hydrolase( EC:3.2.1.-‐ )638721912 9.38 11.49 3.91 down 8.22E-‐03 RRSL_01372 Hypothetical Protein638721913 9.21 11.12 3.42 down 5.33E-‐03 RRSL_01373 Possible TonB-‐dependent receptor638721914 10.16 11.42 2.17 down 1.63E-‐03 RRSL_01375 o Putative lipoprotein638721874 12.01 13.56 2.66 down 6.87E-‐03 RRSL_01406 o c Dihydrolipoamide dehydrogenase( EC:1.8.1.4 )638721875 12.89 14.58 2.92 down 1.03E-‐03 RRSL_01407 o c Dihydrolipoamide succinyltransferase component (E2) of 2-‐oxoglutarate dehydrogenase complex( EC:2.3.1.61 )638721876 11.33 13.1 3.1 down 8.78E-‐03 RRSL_01408 o c 2-‐oxoglutarate dehydrogenase E1 component( EC:1.2.4.2 )638721889 12.69 14 2.24 down 3.15E-‐02 RRSL_01421 o c Glutamine synthetase( EC:6.3.1.2 )638721890 8.78 9.99 2.1 down 3.66E-‐02 RRSL_01422 o c sulfide dehydrogenase precursor638722237 14.07 15.47 2.39 down 1.40E-‐03 RRSL_01451 o c Superoxide dismutase( EC:1.15.1.1 )638722261 8.91 10.38 2.51 down 8.61E-‐04 RRSL_01475 o c Hypothetical Protein638722273 13.2 14.44 2.14 down 4.97E-‐02 RRSL_01488 o c Isocitrate dehydrogenase (NADP)( EC:1.1.1.42 )638722167 9.33 10.96 2.82 down 1.49E-‐02 RRSL_01496 o c Hypothetical Protein638722185 10.01 11.19 2.05 down 7.09E-‐03 RRSL_01514 o Beta-‐hexosaminidase( EC:3.2.1.52 )638721776 11.51 12.77 2.17 down 5.70E-‐03 RRSL_01575 o c Alanine racemase( EC:5.1.1.1 )638721777 9.32 10.58 2.16 down 4.16E-‐03 RRSL_01576 o c DNA repair protein RadA

638721791 10.83 11.99 2.03 down 5.38E-‐03 RRSL_01594 o c Exo-‐poly-‐alpha-‐D-‐galacturonosidase precursor( EC:3.2.1.82 )638721719 10.1 11.66 2.68 down 1.39E-‐02 RRSL_01658 Hypothetical Protein638721721 10.52 11.72 2.09 down 4.23E-‐03 RRSL_01660 o c Arginyl-‐tRNA synthetase( EC:6.1.1.19 )638721724 11.02 12.24 2.1 down 7.80E-‐03 RRSL_01663 o c Oxidoreductase( EC:1.1.1.-‐ )638721734 10.55 11.89 2.3 down 9.95E-‐03 RRSL_01673 Hypothetical Protein638721528 13.65 14.8 2.01 down 3.01E-‐03 RRSL_01676 o c Fumarate hydratase( EC:4.2.1.2 )638721545 8.35 9.86 2.58 down 1.79E-‐03 RRSL_01693 o probable glycogen synthase, glgA( EC:2.4.1.21 )638721558 10.38 12 2.79 down 1.49E-‐03 RRSL_01707 o c Hypothetical Protein638721568 11.39 12.55 2.02 down 5.81E-‐03 RRSL_01717 o c Periplasmic glucans biosynthesis protein mdoG precursor638721324 10.72 11.86 2.01 down 3.03E-‐02 RRSL_01752 o Hypothetical Protein638721326 10.56 11.99 2.43 down 5.92E-‐03 RRSL_01754 o probable transmembrane638721343 10.92 12.09 2.04 down 1.19E-‐02 RRSL_01774 Collagen alpha 2(I) chain precursor638721587 10.55 12.18 2.81 down 1.79E-‐02 RRSL_01785 o Hypothetical protein638721615 10.56 12.05 2.56 down 9.18E-‐03 RRSL_01815 o c Bis(5'-‐nucleosyl)-‐tetraphosphatase (asymmetrical)( EC:3.6.1.17 )638721626 8.18 9.95 3.09 down 3.14E-‐03 RRSL_01826 o c Hypothetical Protein638721627 10.61 12.33 2.99 down 4.91E-‐03 RRSL_01827 o c Mechanosensitive ion channel638721378 10.47 11.88 2.41 down 3.65E-‐02 RRSL_01865 o c Cytochrome c4638721386 9.74 11.39 2.85 down 2.63E-‐04 RRSL_01873 o c Diaminopimelate decarboxylase( EC:4.1.1.20 )638721387 9.63 11.54 3.42 down 8.66E-‐04 RRSL_01874 o Hypothetical protein638721402 8.58 10.11 2.62 down 1.47E-‐02 RRSL_01891 o c toluene tolerance protein TTG2A638721406 10.37 11.96 2.73 down 5.87E-‐03 RRSL_01895 o c toluene tolerance protein TTG2D638721407 10.63 12.23 2.73 down 5.52E-‐03 RRSL_01896 o c toluene tolerance protein TTG2E638721412 9.77 10.96 2.06 down 6.31E-‐03 RRSL_01901 ATP phosphoribosyltransferase( EC:2.4.2.17 )638721413 9.3 10.73 2.45 down 1.33E-‐02 RRSL_01902 o c Histidinol dehydrogenase( EC:1.1.1.23 )638721416 12.6 13.82 2.11 down 2.42E-‐03 RRSL_01905 o c Aspartokinase( EC:2.7.2.4 )638721430 10.4 11.59 2.07 down 4.01E-‐02 RRSL_01919 Hypothetical Protein638721442 12.13 13.66 2.63 down 1.33E-‐02 RRSL_01932 o c Transmembrane hypothetical protein638721444 10.06 11.38 2.27 down 4.22E-‐03 RRSL_01934 o c Hypothetical Protein638721468 9.57 10.83 2.18 down 1.41E-‐02 RRSL_01959 o c lolD LolD638721929 9.22 10.64 2.43 down 3.39E-‐03 RRSL_01964 o Dipeptide-‐binding protein638721935 12.35 14.22 3.32 down 1.55E-‐03 RRSL_01970 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638721936 9.42 11.9 5.04 down 1.25E-‐04 RRSL_01972 o c PTS system, fructose-‐specific IIBC component( EC:2.7.1.69 )638721937 9.68 11.85 4.08 down 2.91E-‐03 RRSL_01973 o c 1-‐phosphofructokinase( EC:2.7.1.56 )638721938 8.33 10.71 4.7 down 9.32E-‐04 RRSL_01974 o c Phosphoenolpyruvate-‐protein phosphotransferase / Phosphocarrier protein HPr / PTS system, glucose-‐specific IIA subunit( EC:2.7.1.69,EC:2.7.3.9 )638721940 9.9 11.74 3.24 down 4.12E-‐04 RRSL_01976 o c anaerobic dehydrogenase638721941 9.24 10.49 2.17 down 1.40E-‐03 RRSL_01977 o c hypothetical protein638721942 10.92 12.31 2.38 down 1.84E-‐04 RRSL_01978 o c Long-‐chain-‐fatty-‐acid-‐-‐CoA ligase( EC:6.2.1.3 )638721954 10.37 11.61 2.14 down 1.07E-‐02 RRSL_01990 o c UDP-‐N-‐acetylmuramoylalanine-‐-‐D-‐glutamate ligase( EC:6.3.2.9 )638721962 8.98 10.68 2.96 down 1.56E-‐02 RRSL_01998 hypothetical protein638721826 11.65 13.27 2.8 down 1.33E-‐02 RRSL_02010 o c signal peptide638721854 11.1 12.92 3.22 down 1.02E-‐03 RRSL_02038 o c ATP-‐dependent protease hslV( EC:3.4.25.-‐ )638721855 9.57 11.68 3.91 down 6.63E-‐04 RRSL_02039 o c heat shock protein chaperone; cpX superfamily638720761 14.34 15.77 2.45 down 5.18E-‐03 RRSL_02051 o c 60 kDa chaperonin GROEL638720763 8.51 9.75 2.13 down 3.43E-‐02 RRSL_02053 o dnaK DnaK638721129 9.27 10.91 2.82 down 1.11E-‐03 RRSL_02108 o c Transcriptional regulators, LysR family638721130 10.5 11.74 2.14 down 2.59E-‐04 RRSL_02109 o c glutarate-‐-‐CoA ligase( EC:6.2.1.6 )638721131 12.82 14.39 2.7 down 1.56E-‐03 RRSL_02110 o c ABC transporter substrate-‐binding protein638721132 9.97 11.51 2.63 down 1.33E-‐03 RRSL_02111 o c ABC transporter ATP-‐binding protein638721133 11.25 12.59 2.3 down 2.84E-‐03 RRSL_02113 o c ABC transporter permease protein638721142 12.86 14.17 2.24 down 1.01E-‐02 RRSL_02122 o c SecY stabilizing membrane protein638721154 9.75 11.29 2.65 down 2.33E-‐02 RRSL_02134 o c Protease activity modulator HflK638721157 8.54 9.92 2.35 down 2.72E-‐03 RRSL_02137 o c Histidyl-‐tRNA synthetase( EC:6.1.1.21 )638721165 10.78 11.93 2.01 down 2.58E-‐04 RRSL_02144 o c Ribose 5-‐phosphate isomerase( EC:5.3.1.6 )638720955 8.65 10.33 2.9 down 7.19E-‐03 RRSL_02173 o c Polyphosphate kinase( EC:2.7.4.1 )638720967 11.19 12.42 2.12 down 3.29E-‐02 RRSL_02184 o c Hypothetical RNA binding protein638720968 10.9 12.45 2.66 down 1.33E-‐02 RRSL_02186 o Hypothetical Protein638720969 10.5 12.2 2.94 down 2.69E-‐02 RRSL_02187 o c Transcription elongation factor greA (transcription cleavage factor)638720970 11.41 12.79 2.36 down 3.86E-‐02 RRSL_02188 o c Carbamoyl-‐phosphate synthase large chain( EC:6.3.5.5 )638720971 12.08 13.48 2.39 down 3.43E-‐03 RRSL_02189 o c Transporter, LysE family638721006 10.4 12.42 3.68 down 6.43E-‐03 RRSL_02226 o Hypothetical Protein638721007 9.04 10.9 3.31 down 1.50E-‐04 RRSL_02227 D-‐alanine aminotransferase( EC:2.6.1.21 )638721011 11.42 13.52 3.91 down 1.32E-‐03 RRSL_02231 o Cytochrome P-‐450638720535 7.95 9.22 2.19 down 3.42E-‐03 RRSL_02275 o Hypothetical protein638720537 12.28 13.43 2.01 down 8.75E-‐03 RRSL_02277 o Transcriptional regulator, AraC family638720538 9.22 10.48 2.18 down 1.43E-‐02 RRSL_02278 o Acyl-‐CoA dehydrogenase, short-‐chain specific( EC:1.3.99.2 )638720539 11.43 13.69 4.33 down 1.24E-‐04 RRSL_02279 o Integral membrane protein638720540 12.32 14.46 3.97 down 3.58E-‐04 RRSL_02280 o Transcriptional regulator638720541 12.13 16.23 15.45 down 2.01E-‐04 RRSL_02281 o Fumarylacetoacetase( EC:3.7.1.2 )638720542 11.94 16.08 15.95 down 1.17E-‐04 RRSL_02282 o Homogentisate 1,2-‐dioxygenase( EC:1.13.11.5 )638720545 10.66 11.85 2.06 down 3.03E-‐02 RRSL_02287 o 4-‐hydroxyphenylacetate 1-‐monooxygenase( EC:1.14.13.18 )638720546 9.35 11.82 5.04 down 4.85E-‐03 RRSL_02288 o Beta-‐lactamase, type II( EC:3.5.2.6 )638720866 10.3 11.63 2.28 down 9.15E-‐04 RRSL_02349 o Outer membrane porin protein 32 precursor638720882 10.59 12.09 2.56 down 4.79E-‐03 RRSL_02369 o c Glutaminyl-‐tRNA synthetase( EC:6.1.1.18 )638720887 10.45 11.95 2.55 down 2.62E-‐02 RRSL_02374 o c Alanyl-‐tRNA synthetase( EC:6.1.1.7 )638720891 10.59 12.41 3.21 down 6.85E-‐04 RRSL_02379 o purine nucleoside permease638720892 9.33 11.42 3.84 down 3.60E-‐04 RRSL_02380 o c purine nucleoside permease

638720928 11.27 12.5 2.13 down 1.91E-‐02 RRSL_02417 DNA-‐binding protein HU638720930 8.17 9.8 2.8 down 1.96E-‐03 RRSL_02419 Hypothetical Protein638720931 8.12 9.58 2.5 down 1.46E-‐02 RRSL_02420 Conserved hypothetical protein638721245 6.92 8.53 2.76 down 1.77E-‐03 RRSL_02451 o Urease beta subunit( EC:3.5.1.5 )638721246 10.41 11.8 2.38 down 2.20E-‐03 RRSL_02452 o Urease alpha subunit( EC:3.5.1.5 )638721247 8.46 9.73 2.19 down 1.19E-‐02 RRSL_02453 o ureE UreE638721248 7.27 8.68 2.4 down 2.33E-‐03 RRSL_02454 o ureF UreF638721249 8.96 10.28 2.26 down 1.89E-‐03 RRSL_02455 o ureG UreG638721270 9.69 11.16 2.52 down 1.05E-‐04 RRSL_02477 o c ABC type dipeptide transporter638721271 11.87 13.02 2.02 down 1.43E-‐02 RRSL_02479 o c Hypothetical Protein638721272 11.91 13.19 2.2 down 2.89E-‐02 RRSL_02480 o c Aconitate hydratase( EC:4.2.1.3 )638721274 13.23 14.6 2.35 down 1.09E-‐02 RRSL_02482 o c Hypothetical Protein638721282 12.27 13.86 2.74 down 1.74E-‐02 RRSL_02490 o c Succinate dehydrogenase flavoprotein subunit( EC:1.3.99.1 )638721283 12.35 13.96 2.77 down 2.09E-‐02 RRSL_02491 o c Succinate dehydrogenase iron-‐sulfur protein( EC:1.3.5.1,EC:1.3.99.1 )638721284 10.79 12.59 3.15 down 5.45E-‐03 RRSL_02492 o c Hypothetical Protein638721289 11.93 13.2 2.18 down 1.59E-‐02 RRSL_02497 o c Aspartate-‐semialdehyde dehydrogenase( EC:1.2.1.11 )638721290 11.48 12.98 2.57 down 1.77E-‐02 RRSL_02498 o c Fimbriae V protein638721299 11.32 12.47 2.01 down 1.88E-‐02 RRSL_02509 o c purF PurF( EC:2.4.2.14 )638721207 10.31 11.66 2.31 down 2.31E-‐02 RRSL_02535 hypothetical protein638721213 9.75 11.21 2.49 down 1.17E-‐02 RRSL_02541 o c Transcriptional regulator, LysR family638721218 7.22 8.75 2.62 down 2.42E-‐03 RRSL_02545 hypothetical protein638721241 10.96 12.61 2.86 down 2.83E-‐02 RRSL_02572 o c 3-‐hydroxybutyryl-‐CoA dehydrogenase( EC:1.1.1.157 )638721478 8.83 10.38 2.66 down 3.92E-‐03 RRSL_02582 o c Trp repressor binding protein638721485 10.47 11.71 2.14 down 3.73E-‐02 RRSL_02590 o c Chorismate synthase( EC:4.2.3.5 )638721492 9.93 11.13 2.08 down 1.19E-‐02 RRSL_02597 o 2-‐hydroxy-‐6-‐oxo-‐6-‐phenylhexa-‐2,4-‐dienoate hydrolase( EC:3.7.1.-‐ )638721507 8.45 9.75 2.23 down 3.23E-‐02 RRSL_02611 Putative resolvase638720033 11.62 12.81 2.07 down 1.57E-‐03 RRSL_02639 o c Prolyl-‐tRNA synthetase( EC:6.1.1.15 )638720021 10.08 11.29 2.09 down 6.45E-‐03 RRSL_02654 o Hypothetical Protein638720013 11.34 13.19 3.27 down 1.10E-‐02 RRSL_02665 o c Outer membrane lipoprotein638720012 12.52 13.89 2.33 down 6.89E-‐04 RRSL_02666 o c Adenosine kinase( EC:2.7.1.20 )638720011 12.95 14.61 2.86 down 2.92E-‐03 RRSL_02667 o c Thioredoxin peroxidase638720009 10.76 12.08 2.26 down 1.56E-‐02 RRSL_02669 o c Ribosomal protein L11 methyltransferase( EC:2.1.1.-‐ )638720008 10.58 12.28 2.94 down 1.11E-‐02 RRSL_02670 o c Biotin carboxylase( EC:6.3.4.14,EC:6.4.1.2 )638720007 11.51 13.15 2.81 down 1.92E-‐02 RRSL_02671 o c Biotin carboxyl carrier protein of acetyl-‐CoA carboxylase( EC:6.4.1.2 )638719998 9.64 10.8 2.02 down 9.02E-‐03 RRSL_02680 o c Shikimate 5-‐dehydrogenase( EC:1.1.1.25 )638719990 11.23 12.92 2.94 down 7.29E-‐03 RRSL_02689 o NADP-‐dependent malic enzyme( EC:1.1.1.40 )638719984 11.96 13.3 2.29 down 1.07E-‐02 RRSL_02696 o c Transketolase( EC:2.2.1.1 )638719983 12.79 13.97 2.05 down 1.64E-‐02 RRSL_02697 o c Glyceraldehyde 3-‐phosphate dehydrogenase( EC:1.2.1.12 )638719978 10.89 12.13 2.15 down 1.92E-‐02 RRSL_02702 o c dapB DapB( EC:1.3.1.26 )638719975 9.28 10.48 2.09 down 1.95E-‐02 RRSL_02705 o c DNA polymerase III, delta subunit( EC:2.7.7.7 )638719974 10.19 11.49 2.24 down 1.33E-‐02 RRSL_02706 o c Gamma-‐glutamyl phosphate reductase( EC:1.2.1.41 )638720680 10.46 12.45 3.6 down 7.96E-‐05 RRSL_02713 o c Coenzyme F390 Synthetase / Phenylacetate-‐coenzyme A ligase( EC:6.2.1.30 )638720685 9.84 11.5 2.86 down 2.92E-‐03 RRSL_02718 o c Hypothetical Protein( EC:4.1.3.27 )638720687 7.6 9.2 2.76 down 3.28E-‐03 RRSL_02720 o c Hypothetical Protein638720689 10.48 11.7 2.1 down 2.96E-‐03 RRSL_02722 o c Indole-‐3-‐glycerol phosphate synthase( EC:4.1.1.48 )638720690 9.06 10.76 2.93 down 5.82E-‐04 RRSL_02723 o c Putative adenylate cyclase family638720701 12.15 13.38 2.12 down 2.41E-‐03 RRSL_02734 o c GTP-‐binding protein, probable translation factor638720709 10.68 12.16 2.51 down 3.16E-‐03 RRSL_02742 o c Hypothetical Protein638720715 11.71 13 2.22 down 1.39E-‐02 RRSL_02748 o c Hypothetical Protein638720721 9.35 10.55 2.08 down 1.47E-‐03 RRSL_02754 o c FecR protein638720728 9.91 12.01 3.89 down 8.25E-‐03 RRSL_02760 o c Stringent starvation protein A638720734 11.55 12.7 2.02 down 7.20E-‐03 RRSL_02766 o c Protease Do( EC:3.4.21.-‐ )638720743 10.67 11.93 2.17 down 1.72E-‐02 RRSL_02775 o c tatB TatB638720746 11.38 12.74 2.33 down 1.81E-‐03 RRSL_02778 o c Phosphoribosyl-‐ATP pyrophosphatase( EC:3.6.1.31 )638720747 11.36 12.62 2.17 down 3.22E-‐03 RRSL_02779 Hypothetical Protein638720657 10.65 12.06 2.41 down 1.51E-‐02 RRSL_02836 o Usf protein638720658 7.96 9.33 2.35 down 1.33E-‐02 RRSL_02837 o transmembrane hypothetical protein638720674 8.83 10.6 3.09 down 1.08E-‐02 RRSL_02853 o Fumarate hydratase class II( EC:4.2.1.2 )638720573 10.29 11.58 2.22 down 2.10E-‐02 RRSL_02888 hypothetical protein638720577 10.04 11.42 2.36 down 9.35E-‐04 RRSL_02891 o c hypothetical protein638720578 9.53 10.81 2.21 down 2.37E-‐03 RRSL_02892 hypothetical protein638720595 10.46 13.07 5.52 down 1.49E-‐03 RRSL_02910 o c transmembrane protein638720597 9.32 11.59 4.35 down 1.53E-‐02 RRSL_02912 o c Sensor protein rstB( EC:2.7.3.-‐ )638720607 11.15 12.39 2.15 down 1.28E-‐02 RRSL_02923 o hypothetical protein638720608 9.49 11.33 3.24 down 2.28E-‐04 RRSL_02924 o c Glycerol kinase( EC:2.7.1.30 )638720350 10.67 12.18 2.59 down 4.97E-‐02 RRSL_02928 o c Ribonuclease P protein component( EC:3.1.26.5 )638720351 11.6 12.85 2.16 down 1.79E-‐02 RRSL_02929 o c Hypothetical cytosolic protein638720352 12.44 13.79 2.31 down 1.12E-‐02 RRSL_02930 o c 60 kDa inner membrane protein YIDC638720360 11.69 13.32 2.8 down 1.64E-‐03 RRSL_02940 o c Drug efflux lipoprotein (FUSA/NODT family)638720361 11.16 12.86 2.93 down 2.63E-‐03 RRSL_02941 o c Acriflavin resistance protein (acrB)638720362 9.08 11.3 4.23 down 3.51E-‐03 RRSL_02942 o c Probable acriflavin resistance lipoprotein A precursor638720366 9.21 11.84 5.6 down 1.67E-‐03 RRSL_02946 o c conserved hypothetical protein638720392 10.58 11.92 2.29 down 9.76E-‐03 RRSL_02973 o c Hypothetical exported protein638720394 8.1 9.63 2.6 down 2.10E-‐02 RRSL_02975 o c prrA PrrA638720409 9.22 10.47 2.15 down 1.58E-‐02 RRSL_02991 o Precorrin-‐3B C17-‐methyltransferase / Precorrin-‐6X reductase( EC:1.3.1.54,EC:2.1.1.131 )638720416 7.55 8.81 2.17 down 8.02E-‐03 RRSL_02998 o Protoporphyrin-‐IX magnesium chelatase subunit D

638720418 9.26 10.55 2.21 down 7.38E-‐03 RRSL_03000 o Ferredoxin, 2Fe-‐2s638720419 10.7 11.89 2.06 down 1.06E-‐02 RRSL_03001 o hupN HupN638720281 9.94 11.59 2.85 down 6.34E-‐03 RRSL_03025 o c Ferric siderophore receptor precursor638720282 8.79 11.65 6.61 down 9.17E-‐04 RRSL_03026 o Cysteine synthase( EC:4.2.99.8 )638720283 7.8 11.21 9.64 down 1.83E-‐04 RRSL_03027 o c Ornithine cyclodeaminase( EC:4.3.1.12 )638720284 7.15 9.86 5.95 down 8.60E-‐05 RRSL_03028 o c Hypothetical IucC protein( EC:6.-‐ )638720285 8.67 10.88 4.2 down 1.24E-‐03 RRSL_03029 o c Transmembrane efflux protein638720286 8.24 11.23 7.2 down 8.00E-‐05 RRSL_03030 o c Hypothetical IucA protein( EC:6.-‐ )638720287 8.97 11.97 7.23 down 3.86E-‐04 RRSL_03031 o c Hypothetical IucC protein( EC:6.-‐ )638720288 7.54 10.31 6.18 down 2.42E-‐04 RRSL_03032 o c 4-‐hydroxy-‐2-‐oxovalerate aldolase( EC:4.1.2.-‐ )638720289 8.33 10.24 3.42 down 3.01E-‐03 RRSL_03033 o c ssd Ssd638720290 8.16 9.67 2.57 down 7.03E-‐04 RRSL_03034 o c Purine/pyrimidine phosphoribosyl transferase( EC:2.4.2.-‐ )638720294 9.4 12.5 7.81 down 3.41E-‐04 RRSL_03038 o Cyanate lyase( EC:4.2.1.104,EC:4.3.99.1 )638720295 11.18 14.51 9.11 down 7.81E-‐05 RRSL_03040 o c Porin638720296 11.79 15.1 8.94 down 5.93E-‐04 RRSL_03041 o c D-‐xylose-‐binding protein638720297 9.99 13.51 10.45 down 1.77E-‐04 RRSL_03042 o c xylG XylG638720298 10.82 13.76 6.96 down 1.34E-‐05 RRSL_03043 o c xylH XylH638720299 8.32 12.14 12.87 down 1.26E-‐05 RRSL_03044 o c Hypothetical Protein638720300 10.18 11.96 3.11 down 9.44E-‐04 RRSL_03045 o c Transcriptional regulatory protein638720317 8.29 9.63 2.3 down 1.08E-‐03 RRSL_03062 o c Hypothetical Protein638720328 9.44 10.59 2.01 down 3.03E-‐03 RRSL_03075 o c putative phosphohydrolases, Icc family638720329 10.17 11.61 2.45 down 3.95E-‐02 RRSL_03076 o c oxidoreductase cytochrome C oxidase polypeptide.638720335 10.59 12.46 3.3 down 1.98E-‐03 RRSL_03083 o c Ribonuclease BN( EC:3.1.-‐ )638720336 7.21 9.12 3.4 down 2.71E-‐03 RRSL_03084 o c Hypothetical Protein638720337 13.01 14.9 3.36 down 1.07E-‐03 RRSL_03085 o c Hypothetical Protein638720338 12.07 14.47 4.78 down 1.16E-‐03 RRSL_03086 o c Two-‐component response regulator638720339 12.87 14.31 2.46 down 1.46E-‐02 RRSL_03087 o c probable sigma-‐54 interacting protein638720341 12.56 14.18 2.79 down 6.00E-‐03 RRSL_03090 o c rpoN RpoN638720342 10.67 12.44 3.09 down 8.89E-‐03 RRSL_03091 o c Hypothetical Protein638720344 9.43 10.97 2.64 down 2.07E-‐03 RRSL_03093 o c Hypothetical Protein638720345 9.3 11.21 3.4 down 2.93E-‐03 RRSL_03094 o c Hypothetical Protein638721080 8.06 9.93 3.3 down 1.41E-‐03 RRSL_03134 o nac Nac638721081 8.14 10.1 3.54 down 7.90E-‐05 RRSL_03135 o Hypothetical Protein638721096 8.95 10.7 3.04 down 2.14E-‐02 RRSL_03152 o c kdpE KdpE638721097 10.9 13.44 5.27 down 5.71E-‐03 RRSL_03153 o c Tricarboxylate-‐binding protein638721108 9.76 12.28 5.19 down 1.79E-‐04 RRSL_03167 o c NAD-‐dependent oxidoreductase638721110 10.74 12.02 2.21 down 3.17E-‐02 RRSL_03169 o c probable lipoprotein638721124 8.34 9.68 2.28 down 8.66E-‐04 RRSL_03184 o c putative hemagglutinin-‐related transmembrane protein638720426 11.8 13.27 2.51 down 3.98E-‐04 RRSL_03188 dnaJ DnaJ638720427 12.82 14.69 3.32 down 6.51E-‐04 RRSL_03189 o c dnaK DnaK638720430 11.15 13.07 3.43 down 1.72E-‐03 RRSL_03192 o c probable heat shock protein 24 (HSP-‐70 cofactor)638720442 10.63 11.8 2.05 down 1.46E-‐02 RRSL_03205 o c Hypothetical Protein638720457 11.45 12.93 2.52 down 1.25E-‐03 RRSL_03222 o c Murein hydrolase exporter638720458 9.79 10.96 2.04 down 2.54E-‐03 RRSL_03223 o c Murein hydrolase export regulator638720046 11.86 13.19 2.28 down 6.22E-‐04 RRSL_03274 o c Zinc protease( EC:3.4.99.-‐ )638720047 10.92 12.97 3.74 down 1.24E-‐04 RRSL_03275 o c Zinc protease( EC:3.4.99.-‐ )638720048 10.02 11.35 2.28 down 5.16E-‐03 RRSL_03276 o c ftsY FtsY638720049 11.14 12.56 2.42 down 1.50E-‐04 RRSL_03278 o c Hypothetical Protein( EC:5.2.1.2 )638720058 12.08 13.24 2.02 down 8.77E-‐03 RRSL_03287 o c RNA polymerase sigma-‐32 factor638720069 11.75 13.09 2.3 down 3.56E-‐02 RRSL_03298 o c Cytochrome c oxidase polypeptide I( EC:1.9.3.1 )638720070 13.44 14.6 2.03 down 3.40E-‐03 RRSL_03299 o c Cytochrome c oxidase polypeptide II( EC:1.9.3.1 )638720086 10.18 11.44 2.17 down 2.33E-‐02 RRSL_03315 o c PTS system, IIA component( EC:2.7.1.69 )638720125 10.71 12.25 2.62 down 4.75E-‐02 RRSL_03354 o c Seryl-‐tRNA synthetase( EC:6.1.1.11 )638720225 10.02 11.75 3.01 down 9.08E-‐03 RRSL_03389 o c Hypothetical Protein638720237 11.47 12.93 2.48 down 8.27E-‐03 RRSL_03401 o c Putative integral membrane protein638720238 11.8 13.59 3.12 down 1.73E-‐02 RRSL_03402 o c Sulfate transporter638719662 10.27 11.53 2.16 down 1.72E-‐02 RRSL_03445 o c yicC YicC638719665 9.3 10.82 2.59 down 9.79E-‐03 RRSL_03447 o c Ribonuclease PH( EC:2.7.7.56 )638719672 10.45 11.93 2.52 down 1.20E-‐02 RRSL_03453 o c Permease638719673 9.04 10.48 2.46 down 2.60E-‐04 RRSL_03454 o c Permease638719675 7.51 8.74 2.13 down 4.69E-‐03 RRSL_03456 o c Regulator of kinase autophosphorylation inhibitor638719676 8.32 9.6 2.2 down 1.22E-‐02 RRSL_03457 o c kipI KipI638719710 11.62 14.24 5.56 down 3.90E-‐04 RRSL_03494 o c Trp repressor binding protein638719711 9.58 13.01 9.74 down 2.03E-‐04 RRSL_03495 o c Pirin638719712 8.87 10.07 2.08 down 8.64E-‐03 RRSL_03496 o c Transcriptional regulators, LysR family638719722 10.5 11.78 2.19 down 2.31E-‐02 RRSL_03505 o c GatB/Yqey domain protein638719729 9.03 10.51 2.53 down 1.78E-‐02 RRSL_03512 o c Exodeoxyribonuclease VII small subunit( EC:3.1.11.6 )638719750 8.6 9.78 2.05 down 5.70E-‐03 RRSL_03535 o Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638719759 8.41 9.59 2.04 down 1.33E-‐04 RRSL_03544 Hypothetical Protein638719876 13.98 15.16 2.06 down 1.66E-‐02 RRSL_03575 o c livH LivH638719877 13.21 14.56 2.31 down 5.85E-‐03 RRSL_03576 o c livM LivM638719878 11.88 13.39 2.6 down 1.31E-‐02 RRSL_03577 o c livG LivG638719879 10.95 12.23 2.2 down 4.83E-‐02 RRSL_03578 o c livF LivF638719903 11.46 12.72 2.17 down 4.22E-‐03 RRSL_03601 o c Cytosol aminopeptidase( EC:3.4.11.1 )638719909 10.76 12.68 3.43 down 1.48E-‐03 RRSL_03607 o Hypothetical exported protein638719940 12.54 14.19 2.83 down 1.46E-‐02 RRSL_03640 o c Superoxide dismutase (Cu-‐Zn)( EC:1.15.1.1 )

638719941 10.48 11.65 2.04 down 1.25E-‐03 RRSL_03641 o c NAD-‐dependent formate dehydrogenase delta subunit (fdsD)( EC:1.2.1.2 )638719944 10.31 11.54 2.12 down 1.47E-‐02 RRSL_03645 o c Argininosuccinate lyase( EC:4.3.2.1 )638720132 12.95 15.36 4.85 down 2.57E-‐04 RRSL_03652 o c Glycine cleavage system H protein638720133 10.65 14.1 9.94 down 1.05E-‐04 RRSL_03653 o c gcvP GcvP( EC:1.4.4.2 )638720134 9.8 12.7 6.77 down 8.97E-‐05 RRSL_03654 o c L-‐serine dehydratase( EC:4.3.1.17 )638720141 13.11 15 3.35 down 8.80E-‐04 RRSL_03661 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638720142 9.47 11.64 4.07 down 1.30E-‐03 RRSL_03662 o c Proline dehydrogenase / Delta-‐1-‐pyrroline-‐5-‐carboxylate dehydrogenase( EC:1.5.1.12,EC:1.5.99.8 )638720144 9.96 11.25 2.22 down 1.56E-‐03 RRSL_03665 o c Uroporphyrinogen decarboxylase( EC:4.1.1.37 )638720158 11.66 13.19 2.62 down 2.00E-‐02 RRSL_03679 o c ATP synthase epsilon chain( EC:3.6.3.14 )638720159 13.49 14.7 2.09 down 1.77E-‐02 RRSL_03680 o c ATP synthase beta chain( EC:3.6.3.14 )638720161 13.19 14.94 3.06 down 9.06E-‐03 RRSL_03682 o c ATP synthase alpha chain( EC:3.6.3.14 )638720165 11.06 12.63 2.69 down 5.08E-‐03 RRSL_03686 o ATP synthase A chain( EC:3.6.3.14 )638720171 10.85 12.31 2.5 down 2.08E-‐04 RRSL_03692 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638720178 8.68 10.2 2.6 down 1.30E-‐02 RRSL_03699 Hypothetical Protein638719808 10.64 12.21 2.7 down 1.83E-‐02 RRSL_03771 o c Hypothetical membrane spanning protein638719814 8.69 9.9 2.1 down 9.33E-‐04 RRSL_03777 o c hypothetical protein638719819 11 12.43 2.44 down 4.82E-‐03 RRSL_03782 o c hypothetical protein638719825 10.64 12.03 2.38 down 6.88E-‐03 RRSL_03790 o c Phosphoribosylformimino-‐5-‐aminoimidazole carboxamide ribotide isomerase( EC:5.3.1.16 )638719827 12.29 14.57 4.4 down 9.30E-‐03 RRSL_03792 o c hypothetical protein638719832 10.25 11.49 2.14 down 3.39E-‐02 RRSL_03797 o c hypothetical protein638719834 12.37 13.53 2.03 down 7.93E-‐03 RRSL_03799 o c Aspartyl-‐tRNA synthetase( EC:6.1.1.12 )638719841 11.09 12.59 2.56 down 3.86E-‐02 RRSL_03806 o c enoyl-‐coa hydratase / 3,2-‐trans-‐enoyl-‐coa isomerase / 3-‐hydroxyacyl-‐coa dehydrogenase( EC:1.1.1.35,EC:4.2.1.17,EC:5.3.3.8 )638719846 12.45 14.73 4.39 down 8.87E-‐03 RRSL_03812 o c gdhA GdhA( EC:1.4.1.3 )638719847 15.02 16.17 2.01 down 2.40E-‐03 RRSL_03813 o c Glutamate/aspartate-‐binding protein638719848 10.9 12.64 3.03 down 6.11E-‐03 RRSL_03814 o c gltJ GltJ638719849 11.56 13.16 2.75 down 1.03E-‐03 RRSL_03815 o c gltK GltK638719850 11.78 13.15 2.35 down 2.20E-‐03 RRSL_03816 o gltL GltL638719852 8.98 10.17 2.07 down 1.36E-‐02 RRSL_03818 Tartrate dehydrogenase( EC:1.1.1.93 )638719450 10.44 11.99 2.67 down 1.48E-‐02 RRSL_03825 o c Acetyl-‐coenzyme A synthetase( EC:6.2.1.1 )638719457 9.06 10.46 2.39 down 6.49E-‐03 RRSL_03832 o c Endonuclease( EC:3.1.-‐ )638719458 10.11 11.56 2.47 down 1.75E-‐02 RRSL_03833 o c 16S rRNA m(5)C 967 methyltransferase( EC:2.1.1.-‐ )638719459 11.04 12.5 2.5 down 9.86E-‐03 RRSL_03834 o c Phosphoribosylglycinamide formyltransferase( EC:2.1.2.2 )638719462 9.41 10.85 2.46 down 1.27E-‐02 RRSL_03837 o c Riboflavin kinase / FMN adenylyltransferase( EC:2.7.1.26,EC:2.7.7.2 )638719463 10.51 12.07 2.69 down 1.27E-‐02 RRSL_03838 o c Isoleucyl-‐tRNA synthetase( EC:6.1.1.5 )638719470 10.99 13.15 4.04 down 4.31E-‐03 RRSL_03846 o c Cold shock protein638719498 10.87 12.3 2.45 down 1.57E-‐02 RRSL_03878 o c Phosphatidylserine decarboxylase( EC:4.1.1.65 )638719499 10.32 11.48 2.04 down 2.76E-‐02 RRSL_03879 o c CDP-‐diacylglycerol-‐-‐serine O-‐phosphatidyltransferase( EC:2.7.8.8 )638719500 11.1 12.4 2.23 down 4.76E-‐02 RRSL_03880 o c 2-‐isopropylmalate synthase( EC:4.1.3.12 )638719507 9.8 11.92 3.93 down 8.16E-‐03 RRSL_03888 o c Triosephosphate isomerase( EC:5.3.1.1 )638719508 9.89 11.75 3.29 down 2.32E-‐02 RRSL_03889 o c Protein translocase subunit secG638719512 11.57 12.93 2.33 down 2.75E-‐02 RRSL_03892 o c NADH-‐quinone oxidoreductase chain C( EC:1.6.5.3,EC:1.6.99.5 )638719516 9.18 11.15 3.55 down 2.36E-‐02 RRSL_03896 o c NADH-‐quinone oxidoreductase chain G( EC:1.6.5.3 )638719521 12.48 13.66 2.05 down 2.78E-‐02 RRSL_03901 o c NADH-‐quinone oxidoreductase chain L( EC:1.6.5.3 )638719523 11.41 12.71 2.23 down 2.83E-‐02 RRSL_03903 o c NADH-‐quinone oxidoreductase chain N( EC:1.6.5.3 )638719574 8.27 9.52 2.15 down 8.16E-‐03 RRSL_03955 o c hypothetical protein638719574 8.27 9.52 2.15 down 8.16E-‐03 RRSL_03955 o c hypothetical protein638719576 9.96 11.71 3.04 down 6.27E-‐04 RRSL_03957 hypothetical protein638719606 8.46 9.8 2.3 down 1.66E-‐02 RRSL_03988 o c gspF GspF638719608 8.92 10.33 2.41 down 1.84E-‐02 RRSL_03990 o c gspE GspE638719612 8.76 9.91 2.01 down 2.59E-‐02 RRSL_03994 o c gspL GspL638719615 8.73 10.18 2.49 down 1.29E-‐02 RRSL_03997 o c gspI GspI638719620 10.44 13.25 6.36 down 1.20E-‐03 RRSL_04002 o c 4-‐hydroxyphenylpyruvate dioxygenase( EC:1.13.11.27 )638719628 7.9 9.46 2.67 down 5.93E-‐03 RRSL_04011 o c hypothetical protein638719244 11.36 13.57 4.2 down 1.20E-‐04 RRSL_04062 Hypothetical Protein638719250 11.46 12.83 2.35 down 5.53E-‐03 RRSL_04068 o c Glutathione-‐dependent formaldehyde dehydrogenase( EC:1.2.1.1 )638719251 9.03 10.53 2.56 down 2.23E-‐02 RRSL_04069 o c S-‐formylglutathione hydrolase( EC:3.1.1.1,EC:3.1.2.12 )638719252 9.88 11.36 2.52 down 1.07E-‐02 RRSL_04070 Hypothetical Protein638719258 10.25 11.8 2.65 down 4.32E-‐03 RRSL_04077 o c Hypothetical Protein638719259 9.54 11.19 2.83 down 2.09E-‐02 RRSL_04078 o Hypothetical Protein638719261 8.67 10.15 2.53 down 8.48E-‐04 RRSL_04080 Hypothetical protein638719285 11.55 13.45 3.38 down 5.41E-‐03 RRSL_04104 o c Fructose-‐bisphosphate aldolase( EC:4.1.2.13 )638719286 10.88 12.37 2.55 down 1.08E-‐02 RRSL_04105 o c Hypothetical Protein( EC:2.7.1.40 )638719287 10.49 12.37 3.33 down 9.70E-‐03 RRSL_04106 o c Phosphoglycerate kinase( EC:2.7.2.3 )638719291 11.12 12.6 2.52 down 3.17E-‐03 RRSL_04110 o c Branched-‐chain amino acid aminotransferase( EC:2.6.1.42 )638719293 10.26 11.66 2.39 down 1.72E-‐02 RRSL_04112 o c ADP-‐heptose-‐-‐LPS heptosyltransferase II( EC:2.-‐ )638719325 9.46 10.73 2.19 down 1.02E-‐02 RRSL_04148 o c NADPH-‐dependent glutamate synthase beta chain and related oxidoreductases638719326 11.47 12.72 2.16 down 4.05E-‐03 RRSL_04149 o c probable signal peptide638719335 10.8 12.15 2.31 down 1.57E-‐02 RRSL_04159 o c Glycyl-‐tRNA synthetase beta chain( EC:6.1.1.14 )638719359 9.97 11.46 2.55 down 8.25E-‐03 RRSL_04185 o c Hypothetical Protein638719360 11.75 13.45 2.93 down 5.54E-‐04 RRSL_04186 o c Putative integral membrane protein638719379 9.1 10.35 2.15 down 3.40E-‐03 RRSL_04205 o c Queuosine biosynthesis protein QueC638719381 13.68 14.99 2.25 down 2.70E-‐02 RRSL_04207 o c Peptidoglycan-‐associated lipoprotein638719382 11.98 13.38 2.38 down 1.38E-‐03 RRSL_04208 o c TolB protein638719383 10.27 11.78 2.6 down 1.70E-‐02 RRSL_04209 o c TolA protein638719384 10.86 12.15 2.21 down 3.23E-‐02 RRSL_04210 o c TolR protein638719387 13.2 14.51 2.25 down 1.15E-‐02 RRSL_04213 o c Serine hydroxymethyltransferase( EC:2.1.2.1 )

638719402 9.78 11.32 2.64 down 1.19E-‐02 RRSL_04229 o c GTP cyclohydrolase II / 3,4-‐dihydroxy-‐2-‐butanone-‐4-‐phosphate synthase( EC:3.5.4.25,EC:4.1.2.-‐ )638719404 12.18 13.39 2.1 down 1.16E-‐02 RRSL_04231 o c N utilization substance protein B638719414 9.32 10.51 2.07 down 1.23E-‐03 RRSL_04240 o c tRNA (m(7)G46) methyltransferase( EC:2.1.1.33 )638719420 11.59 12.96 2.34 down 8.80E-‐03 RRSL_04246 o c Protein-‐L-‐isoaspartate O-‐methyltransferase( EC:2.1.1.77 )638719421 8.5 10.53 3.71 down 2.18E-‐03 RRSL_04247 o c Hypothetical Protein638719422 10.16 11.4 2.15 down 9.42E-‐04 RRSL_04248 o c Type I secretion outer membrane protein638719423 9.59 11.23 2.83 down 3.79E-‐04 RRSL_04249 o c Hypothetical Protein638719145 11.53 13.31 3.13 down 1.21E-‐02 RRSL_04295 o c Glucosamine-‐-‐fructose-‐6-‐phosphate aminotransferase (isomerizing)( EC:2.6.1.16 )638719147 9.56 10.88 2.26 down 5.08E-‐03 RRSL_04297 o c tRNA s2C32 biosynthesis protein TtcA638719176 11.07 12.48 2.42 down 5.70E-‐03 RRSL_04327 o c N-‐acetyl-‐gamma-‐glutamyl-‐phosphate reductase( EC:1.2.1.38 )638719197 11.72 13.19 2.5 down 2.84E-‐04 RRSL_04350 o c Amino-‐acid ABC transporter binding protein ybeJ precursor638719206 11.21 13.17 3.52 down 1.60E-‐03 RRSL_04359 o c thiC ThiC638719207 9.16 10.54 2.36 down 2.54E-‐03 RRSL_04360 o c Glycine oxidase( EC:1.4.3.19 )638719208 8.04 9.42 2.37 down 1.34E-‐03 RRSL_04362 o c thiG ThiG638719221 10.75 11.97 2.11 down 1.91E-‐03 RRSL_04376 o c Soluble lytic murein transglycosylase( EC:3.2.1.-‐ )638719224 10.53 11.77 2.15 down 7.50E-‐03 RRSL_04380 o c conserved hypothetical protein638719225 8.78 10.07 2.21 down 5.85E-‐03 RRSL_04381 o c tRNA nucleotidyltransferase( EC:2.7.7.25 )638718940 12.41 13.79 2.36 down 1.27E-‐02 RRSL_04395 o c Aromatic-‐amino-‐acid aminotransferase( EC:2.6.1.1,EC:2.6.1.57 )638718941 11.26 12.43 2.05 down 1.13E-‐02 RRSL_04396 o c phaZ PhaZ638718944 11.14 12.37 2.13 down 1.55E-‐03 RRSL_04399 o c Oxygen-‐insensitive NAD(P)H nitroreductase( EC:1.-‐ )638718956 11.56 12.82 2.18 down 1.68E-‐03 RRSL_04412 o c hypothetical cytosolic protein638718957 10.78 12.88 3.89 down 1.29E-‐03 RRSL_04413 o c htpG HtpG638718970 11.14 12.31 2.04 down 2.22E-‐02 RRSL_04426 o c Topoisomerase IV subunit B638718982 8.72 10.23 2.59 down 5.68E-‐03 RRSL_04437 hypothetical protein638718983 9.1 10.31 2.09 down 6.31E-‐03 RRSL_04440 o hypothetical protein638718992 9.07 10.53 2.49 down 7.93E-‐03 RRSL_04450 o c hypothetical cytosolic protein638718993 11.24 12.82 2.72 down 3.03E-‐03 RRSL_04451 o c hypothetical protein638719000 9.46 10.91 2.48 down 2.11E-‐02 RRSL_04458 o c Molybdopterin biosynthesis mog protein638719009 11.52 12.75 2.13 down 4.88E-‐02 RRSL_04467 o c rimM RimM638719016 9.94 12.95 7.27 down 1.90E-‐03 RRSL_04475 o c D-‐amino acid dehydrogenase small subunit( EC:1.4.99.1 )638719017 8.96 10.2 2.14 down 1.89E-‐03 RRSL_04476 o c Acyl-‐CoA dehydrogenase( EC:1.3.99.3 )638719018 11.43 12.72 2.21 down 5.50E-‐03 RRSL_04477 o c Electron transfer flavoprotein beta-‐subunit638719060 11.07 12.53 2.51 down 1.39E-‐02 RRSL_04521 o c Oligopeptidase A( EC:3.4.24.70 )638719061 10.7 12.14 2.45 down 1.12E-‐02 RRSL_04522 o c Methylenetetrahydrofolate dehydrogenase (NADP+) / Methenyltetrahydrofolate cyclohydrolase( EC:1.5.1.5,EC:3.5.4.9 )638719064 13.77 15.16 2.37 down 5.52E-‐03 RRSL_04525 o c Pyruvate dehydrogenase E1 component( EC:1.2.4.1 )638719065 10.98 13.02 3.72 down 9.71E-‐03 RRSL_04526 o c Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex( EC:2.3.1.12 )638719066 12.53 14.22 2.92 down 2.43E-‐03 RRSL_04527 o c hypothetical protein638719067 10.5 12.51 3.65 down 1.40E-‐02 RRSL_04528 o c Dihydrolipoamide dehydrogenase( EC:1.8.1.4 )638719088 9.75 11.9 4.02 down 9.42E-‐04 RRSL_04550 o TRANSCRIPTION ACCESSORY PROTEIN (S1 RNA binding domain)638719094 11.07 12.79 2.99 down 2.09E-‐02 RRSL_04555 o c Poly(3-‐hydroxyalkanoate) polymerase( EC:2.3.1.-‐ )638719095 12.41 14.08 2.87 down 1.46E-‐02 RRSL_04556 o c phbA PhbA( EC:2.3.1.9 )638719096 12.97 14.26 2.22 down 1.23E-‐02 RRSL_04557 o c Acetoacetyl-‐CoA reductase( EC:1.1.1.36 )638719097 12.7 13.9 2.09 down 9.65E-‐03 RRSL_04558 o c Conserved hypothetical protein638719104 9.69 10.99 2.23 down 1.46E-‐02 RRSL_04565 o c Phosphoserine phosphatase( EC:3.1.3.3 )638719116 9.2 10.35 2.02 down 1.48E-‐03 RRSL_04579 o c transmembrane protein transport/efflux protein638719123 13.1 14.41 2.25 down 1.46E-‐02 RRSL_04585 o c ATP-‐dependent Clp protease proteolytic subunit( EC:3.4.21.92 )638719129 11.65 12.91 2.17 down 1.19E-‐02 RRSL_04589 o c Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638718797 8.68 10.01 2.27 down 1.12E-‐02 RRSL_04649 o Fic family protein638718798 8.9 10.86 3.55 down 3.55E-‐03 RRSL_04650 Hypothetical Protein638718825 8.72 10.26 2.63 down 6.28E-‐04 RRSL_04678 o c Acriflavin resistance periplasmic protein638718839 8.99 10.19 2.07 down 9.95E-‐03 RRSL_04693 o Type I protein secretion ATP-‐binding protein / Type I protein secretion transmembrane subunit / Type I secretion processing peptidase638718846 10.69 12.16 2.51 down 1.80E-‐02 RRSL_04700 Hypothetical Protein638718847 10.51 12.16 2.83 down 1.25E-‐02 RRSL_04701 Hypothetical Protein638718889 9.47 11.75 4.41 down 6.95E-‐04 RRSL_04747 o Hypothetical Protein638718890 9.28 12.19 6.83 down 2.65E-‐04 RRSL_04748 o Hypothetical Protein638718891 10.33 11.82 2.55 down 5.86E-‐03 RRSL_04749 o Hypothetical Protein638718892 9.75 11.51 3.07 down 3.07E-‐03 RRSL_04750 o Alpha,alpha-‐trehalose-‐phosphate synthase (UDP-‐forming)( EC:2.4.1.15 )638718893 7.56 9.7 4 down 1.88E-‐04 RRSL_04751 o Trehalose-‐phosphatase( EC:3.1.3.12 )638718898 9.17 10.36 2.07 down 1.39E-‐02 RRSL_04756 o c Hypothetical Protein638718914 10.81 12.29 2.54 down 2.66E-‐02 RRSL_04773 o c Phosphogluconate dehydratase( EC:4.2.1.12 )638718915 10.68 12.93 4.34 down 9.18E-‐03 RRSL_04774 o c Glucose-‐6-‐phosphate 1-‐dehydrogenase( EC:1.1.1.49 )638718916 8.59 10.68 3.86 down 8.96E-‐03 RRSL_04775 o c 6-‐phosphogluconolactonase( EC:3.1.1.31 )638718917 8.55 10.21 2.86 down 6.35E-‐03 RRSL_04776 o c Glucokinase( EC:2.7.1.2 )638718924 10.59 11.84 2.16 down 3.50E-‐02 RRSL_04785 o c Thiamin-‐phosphate pyrophosphorylase( EC:2.5.1.3 )638718928 10.27 11.49 2.11 down 1.33E-‐02 RRSL_04789 o c Hypothetical Protein638718929 7.84 9.42 2.72 down 1.24E-‐02 RRSL_04790 o c Hypothetical Protein638718930 10.61 11.76 2.02 down 7.89E-‐03 RRSL_04791 o Hypothetical protein638722471 13.75 15.24 2.55 down 1.35E-‐02 RRSL_RNA018 ( tRNA )638718741 7.61 8.26 1.43 down 6.84E-‐02 RRSL_04592 2-‐hydroxychromene-‐2-‐carboxylate isomerase( EC:5.3.99.-‐ )638718742 9.26 8.85 1.46 up 1.52E-‐01 RRSL_04593 Hypothetical Protein638718744 12.14 11.43 1.8 up 1.57E-‐02 RRSL_04595 o 1-‐acyl-‐sn-‐glycerol-‐3-‐phosphate acyltransferase( EC:2.3.1.51 )638718753 9.86 8.84 2.24 up 5.61E-‐02 RRSL_04604 Hypothetical Protein638718764 7.86 8.45 1.36 down 1.57E-‐01 RRSL_04615 o Hypothetical Protein638718765 8.98 8.92 1.15 up 4.35E-‐01 RRSL_04616 o ABC transporter ATP-‐binding protein638718766 11.11 10.3 1.94 up 2.19E-‐01 RRSL_04617 o ABC transporter permease protein638718767 9.33 9 1.39 up 8.58E-‐02 RRSL_04618 o ABC transporter substrate-‐binding protein

638718771 8.46 7.99 1.53 up 2.36E-‐01 RRSL_04622 o Hypothetical Protein638718772 8.99 7.29 3.6 up 1.05E-‐01 RRSL_04624 o Hypothetical Protein638718773 8.81 8.71 1.19 up 5.86E-‐01 RRSL_04623 o Hypothetical Protein638718774 9.61 9.61 1.1 up 5.23E-‐01 RRSL_04625 o c Translation initiation inhibitor638718775 9.83 10.06 1.06 down 6.91E-‐01 RRSL_04627 Serine racemase( EC:5.1.1.-‐ )638718776 10.32 11.52 2.09 down 1.09E-‐01 RRSL_04626 o Hypothetical Protein638718777 9.54 10.08 1.32 down 9.49E-‐02 RRSL_04628 o Sulfate transporter638718778 9.48 9.41 1.15 up 4.45E-‐01 RRSL_04629 o Hypothetical Protein638718779 9.03 8.61 1.47 up 1.31E-‐02 RRSL_04630 o Virulence protein638718780 8.23 8.33 1.03 up 8.43E-‐01 RRSL_04631 o oxacillin resistance-‐associated protein FmtC638718782 7.45 7.68 1.06 down 7.21E-‐01 RRSL_04633 o Hypothetical Protein638718783 8.15 7.53 1.7 up 2.32E-‐02 RRSL_04634 o transmembrane hypothetical638718784 13.24 12.89 1.41 up 1.90E-‐02 RRSL_04635 o Hypothetical Protein638718785 9.3 9.74 1.24 down 2.79E-‐01 RRSL_04636 o Hypothetical Protein638718786 9.86 9.51 1.41 up 1.84E-‐01 RRSL_04637 Hypothetical Protein638718787 12.36 11.76 1.68 up 9.94E-‐03 RRSL_04638 o 1-‐aminocyclopropane-‐1-‐carboxylate oxidase( EC:1.-‐ )638718788 12.69 13.2 1.29 down 1.48E-‐01 RRSL_04639 o probable oxidoreductase L-‐ascorbate oxidase (ascorbase)638718789 8.94 9.06 1.01 up 9.56E-‐01 RRSL_04640 o c Protein U precursor638718790 8.11 8.55 1.23 down 4.46E-‐01 RRSL_04641 o sefC SefC638718791 8.89 9.88 1.8 down 1.43E-‐01 RRSL_04642 o ecpD EcpD638718792 13.1 13.27 1.02 down 9.13E-‐01 RRSL_04643 o Protein U precursor638718795 13.86 14.71 1.64 down 2.45E-‐02 RRSL_04647 Hypothetical Protein638718796 11.35 12.26 1.71 down 1.08E-‐01 RRSL_04648 Superfamily I DNA helicase638718799 8.47 8.89 1.21 down 1.92E-‐01 RRSL_04651 o Hypothetical Protein638718800 7.87 7.62 1.31 up 2.00E-‐01 RRSL_04652 Hypothetical Protein638718801 8.01 8.02 1.1 up 1.92E-‐01 RRSL_04653 Hypothetical Protein638718802 16.32 16.44 1.01 up 8.97E-‐01 RRSL_04654 Hypothetical Protein638718803 9.97 9.63 1.4 up 1.33E-‐01 RRSL_04656 Hypothetical Protein638718805 8.69 8.36 1.39 up 9.15E-‐02 RRSL_04657 o c Hypothetical Protein638718806 9.12 8.96 1.23 up 1.67E-‐01 RRSL_04658 o c Na+ driven multidrug efflux pump638718807 9.6 9.06 1.61 up 4.33E-‐02 RRSL_04659 Hypothetical Protein638718811 11.66 12.8 2 down 6.34E-‐03 RRSL_04663 o c Hypothetical Protein638718812 7.61 7.18 1.49 up 1.05E-‐01 RRSL_04664 o c Probable transmembrane methyl-‐accepting chemotaxis protein638718813 8.53 8.62 1.04 up 8.48E-‐01 RRSL_04665 o c Sensor protein FixL( EC:2.7.3.-‐ )638718816 9.49 9.19 1.36 up 7.56E-‐02 RRSL_04668 o Hypothetical Protein638718817 7.42 7.93 1.29 down 2.24E-‐01 RRSL_04669 Hypothetical Protein638718819 13.33 13 1.39 up 1.27E-‐01 RRSL_04671 o Hypothetical Protein638718820 11.82 11.82 1.11 up 5.73E-‐01 RRSL_04672 o Hypothetical Protein638718821 13.42 14.51 1.92 down 7.69E-‐04 RRSL_04673 o Hypothetical Protein638718822 8.29 9.29 1.81 down 8.96E-‐03 RRSL_04675 o Type I secretion outer membrane protein638718823 9.5 10.2 1.47 down 4.04E-‐02 RRSL_04676 o c Transmembrane drug efflux pump638718824 8.2 9.09 1.69 down 4.00E-‐02 RRSL_04677 o c Transmembrane drug efflux pump638718826 10.23 10.56 1.14 down 2.14E-‐01 RRSL_04679 o c ompR OmpR638718827 9.15 9.37 1.06 down 6.02E-‐01 RRSL_04680 o c Osmolarity sensor protein envZ( EC:2.7.3.-‐ )638718828 13.15 13.09 1.15 up 1.18E-‐01 RRSL_04681 o Hypothetical Protein638718829 9.56 10.27 1.48 down 2.71E-‐03 RRSL_04682 o c Undecaprenyl-‐phosphate-‐4-‐amino-‐L-‐arabinose-‐-‐ lipid A 4-‐amino-‐L-‐arabinosyltransferase( EC:2.4.2.-‐ )638718830 10.1 8.86 2.6 up 1.44E-‐01 RRSL_04683 o c Hypothetical Protein638718831 8.78 9.39 1.39 down 2.59E-‐02 RRSL_04684 o c 3,4-‐dihydroxy-‐2-‐butanone-‐4-‐phosphate synthase( EC:4.1.2.-‐ )638718832 11.76 11.38 1.43 up 7.03E-‐02 RRSL_04685 o c Gluconate permease638718833 10.29 10.03 1.32 up 1.13E-‐01 RRSL_04687 o c DfrA protein638718834 8.32 8.85 1.31 down 2.94E-‐02 RRSL_04688 o c D-‐aminoacylase( EC:3.5.1.81 )638718835 8.36 9 1.41 down 5.91E-‐02 RRSL_04689 o c Transcriptional regulator, RpiR family638718836 13.01 11.82 2.51 up 7.48E-‐02 RRSL_04690 o c D-‐serine dehydratase( EC:4.2.1.14 )638718837 8.68 9.22 1.31 down 8.63E-‐02 RRSL_04691 o c 2-‐dehydro-‐3-‐deoxygluconokinase( EC:2.7.1.45 )638718838 10.89 11.75 1.65 down 2.41E-‐03 RRSL_04692 o Type I secretion adaptor protein (HlyD family)638718840 11.47 11.94 1.26 down 3.20E-‐01 RRSL_04694 o Transmembrane type 1 secretion system outer membrane efflux protein638718841 12.58 13.6 1.84 down 2.32E-‐02 RRSL_04695 Hypothetical Protein638718842 14.13 14.39 1.09 down 4.74E-‐01 RRSL_04696 Hypothetical Protein638718843 13.78 14.23 1.24 down 1.88E-‐01 RRSL_04697 Hypothetical Protein638718844 14.75 15.17 1.21 down 3.97E-‐02 RRSL_04698 Hypothetical Protein638718845 13.41 14.17 1.53 down 2.11E-‐02 RRSL_04699 Hypothetical Protein638718848 13.33 14.24 1.71 down 2.53E-‐02 RRSL_04702 Hypothetical Protein638718849 13.29 14.36 1.9 down 7.10E-‐03 RRSL_04703 Hypothetical Protein638718850 8.24 8.42 1.03 down 7.95E-‐01 RRSL_04705 o c Two component system histidine kinase / Two component response regulator( EC:2.7.3.-‐ )638718851 9.05 8.82 1.29 up 2.19E-‐01 RRSL_04706 o c Macrolide-‐efflux protein638718852 10.87 10.67 1.26 up 1.97E-‐01 RRSL_04708 o c Hypothetical Protein638718854 10.13 10.28 1.01 down 9.53E-‐01 RRSL_04710 o c Acid phosphatase( EC:3.1.3.2 )638718856 10.28 10.51 1.07 down 7.90E-‐01 RRSL_04712 o c integral membrane protein / hemolysin638718857 9.2 9.44 1.07 down 8.32E-‐01 RRSL_04713 o c Hypothetical Protein638718858 7.8 8.61 1.59 down 2.18E-‐01 RRSL_04714 o Hypothetical Protein638718859 9.44 9.34 1.18 up 5.99E-‐01 RRSL_04715 o Transcriptional regulator, TetR family638718860 9.02 8.61 1.47 up 1.44E-‐01 RRSL_04716 o Hypothetical Protein638718861 8.9 9.35 1.24 down 1.35E-‐01 RRSL_04717 o c Sensor protein baeS( EC:2.7.3.-‐ )638718862 11.75 11.23 1.58 up 6.33E-‐02 RRSL_04718 o c Hypothetical Protein638718863 11.02 10.73 1.35 up 1.33E-‐02 RRSL_04719 o c Hypothetical Protein638718864 10.88 10.25 1.71 up 3.13E-‐03 RRSL_04720 o c Universal stress protein family

638718865 12.56 12.1 1.52 up 2.37E-‐02 RRSL_04721 o c Hypothetical Protein638718866 10.07 10.23 1.02 down 8.78E-‐01 RRSL_04722 o c Transcriptional regulator, AraC family638718867 7.74 7.6 1.22 up 9.55E-‐02 RRSL_04723 o c Hypothetical Protein638718869 7.27 7.68 1.21 down 3.67E-‐01 RRSL_04726 Hypothetical Protein638718870 8.32 7.51 1.94 up 1.69E-‐01 RRSL_04727 o c Sensory box/GGDEF family protein638718872 9.49 9.83 1.15 down 2.86E-‐01 RRSL_04729 o c Transporter638718873 7.67 7.82 1 down 9.96E-‐01 RRSL_04730 o c modC ModC638718874 12.31 11.02 2.69 up 1.96E-‐01 RRSL_04731 o c modB ModB638718875 9.98 10.47 1.28 down 2.24E-‐01 RRSL_04732 o c Glutaminase( EC:3.5.1.2 )638718876 9.31 9.12 1.26 up 3.94E-‐01 RRSL_04733 o c Hypothetical Protein638718878 12.18 12.86 1.46 down 3.27E-‐02 RRSL_04735 o c Glutamate/aspartate-‐binding protein638718879 11.15 10.37 1.9 up 2.90E-‐03 RRSL_04736 o Hypothetical Protein638718880 6.76 6.99 1.06 down 7.61E-‐01 RRSL_04737 Hypothetical Protein638718881 8.3 7.92 1.44 up 1.17E-‐01 RRSL_04738 Arginine exporter638718882 7.42 7.91 1.28 down 2.52E-‐01 RRSL_04739 o Probable outer membrane drug efflux protein638718883 8.34 8.5 1.02 down 9.60E-‐01 RRSL_04740 o c Transmembrane multidrug-‐efflux system lipoprotein638718884 7.57 8.35 1.56 down 8.78E-‐03 RRSL_04741 o c Probable transmembrane multidrug efflux system protein638718885 7.33 8.36 1.86 down 2.86E-‐02 RRSL_04742 o c Hypothetical Protein638718886 11.05 11.84 1.57 down 9.06E-‐02 RRSL_04743 o c Transcriptional regulators, LysR family638718887 15.35 15.27 1.17 up 8.34E-‐02 RRSL_04744 o c Membrane-‐bound lytic murein transglycosylase B( EC:3.2.1.-‐ )638718888 7.32 7.5 1.03 down 8.77E-‐01 RRSL_04745 o c Zinc finger protein638718894 11.06 10.89 1.25 up 2.88E-‐01 RRSL_04752 Hypothetical Protein638718895 11.06 11.19 1.01 up 9.41E-‐01 RRSL_04753 o c Hypothetical Protein638718896 8.66 9.3 1.42 down 3.22E-‐02 RRSL_04754 o c Hypothetical Protein638718897 10.81 11.83 1.84 down 1.17E-‐02 RRSL_04755 o c UDP-‐glucose 4-‐epimerase( EC:5.1.3.2 )638718899 8.89 7.64 2.62 up 9.28E-‐02 RRSL_04757 o Probable transmembrane methyl-‐accepting chemotaxis protein638718900 11.94 12.14 1.05 down 9.01E-‐01 RRSL_04758 o H-‐NS-‐like proteins638718901 10.76 10.31 1.5 up 7.65E-‐03 RRSL_04759 o c Hypothetical Protein638718903 9.6 9.29 1.37 up 6.72E-‐02 RRSL_04761 o c Transcriptional regulators, LysR family638718904 10.11 9.95 1.23 up 1.82E-‐01 RRSL_04762 o Hypothetical Protein638718905 10.47 10.71 1.07 down 6.00E-‐01 RRSL_04763 o Hypothetical Protein638718910 10.34 9.57 1.88 up 9.18E-‐03 RRSL_04769 o c Alternative cytochrome C oxidase polypeptide II( EC:1.9.3.1 )638718911 9.3 8.49 1.94 up 1.59E-‐02 RRSL_04770 o c Hypothetical Protein638718912 8.97 9.59 1.38 down 3.56E-‐02 RRSL_04771 o c Hypothetical Protein638718913 14.23 14.68 1.24 down 1.65E-‐01 RRSL_04772 o c Universal stress protein family638718919 6.81 6.79 1.12 up 5.75E-‐01 RRSL_04779 o c Hypothetical Protein638718920 8.45 8.93 1.26 down 9.75E-‐02 RRSL_04780 o c Sensor protein qseC( EC:2.7.3.-‐ )638718921 8.9 8.54 1.42 up 6.51E-‐02 RRSL_04782 o c Protease Do( EC:3.4.21.-‐ )638718922 8.99 9.78 1.56 down 1.47E-‐02 RRSL_04783 o c 1,3-‐propanediol dehydrogenase( EC:1.1.1.202 )638718923 11.02 11.88 1.65 down 1.19E-‐02 RRSL_04784 o c Transporter638718925 14.49 14.84 1.16 down 8.81E-‐02 RRSL_04786 o c Hypothetical Protein638718927 11.49 11.91 1.21 down 5.67E-‐01 RRSL_04788 o c Hypothetical Protein638718932 7.68 7.56 1.19 up 5.30E-‐01 RRSL_04793 o Hemolysin638718933 13.93 13.74 1.26 up 4.58E-‐02 RRSL_04388 o c D-‐ribose-‐binding protein638718934 8.76 8.65 1.19 up 3.47E-‐01 RRSL_04389 o c Transporter638718936 10.41 9.56 1.99 up 5.19E-‐02 RRSL_04391 o c Transcriptional regulator, LacI family638718937 8.44 8.38 1.15 up 4.33E-‐01 RRSL_04392 o c Ribokinase( EC:2.7.1.15 )638718938 10.96 10.3 1.74 up 3.54E-‐02 RRSL_04393 o c Site-‐specific recombinase638718939 9.79 10.27 1.26 down 6.12E-‐02 RRSL_04394 o c Excinuclease ABC subunit B638718942 9.35 9.55 1.04 down 6.95E-‐01 RRSL_04397 o c Transcriptional regulator, TetR family638718943 9.09 9.56 1.25 down 2.65E-‐02 RRSL_04398 Endonuclease III( EC:4.2.99.18 )638718946 9.38 8.65 1.82 up 9.63E-‐02 RRSL_04402 o c Transporter, drug/metabolite exporter family638718947 13.12 14.08 1.76 down 1.69E-‐02 RRSL_04403 o c hypothetical protein638718948 14.61 14.98 1.17 down 2.46E-‐01 RRSL_04404 o c Cytochrome c-‐554(548)638718949 11.25 10.82 1.48 up 3.82E-‐04 RRSL_04405 o c ATP-‐dependent protease subunit638718950 10.43 10.31 1.19 up 1.07E-‐01 RRSL_04406 o c hypothetical protein638718952 8.5 8.99 1.27 down 1.08E-‐01 RRSL_04408 o c Spermidine synthase( EC:2.5.1.16 )638718953 12.03 11.82 1.27 up 4.85E-‐01 RRSL_04409 o c Integral membrane protein638718954 9.03 7.81 2.58 up 2.60E-‐01 RRSL_04410 o Transcriptional regulator, ArsR family638718955 9.75 9.84 1.04 up 8.15E-‐01 RRSL_04411 o Glutathione S-‐transferase( EC:2.5.1.18 )638718958 10.23 10.43 1.04 down 5.33E-‐01 RRSL_04414 o c Transcriptional regulatory protein638718959 8.8 8.84 1.08 up 5.05E-‐01 RRSL_04415 o c Metal-‐dependent hydrolase related to alanyl-‐tRNA synthetase638718960 12.41 13 1.36 down 2.16E-‐02 RRSL_04416 Aminotransferase class I family638718961 13.9 13.86 1.13 up 4.63E-‐01 RRSL_04417 o c Glutathione S-‐transferase( EC:2.5.1.18 )638718962 9.11 10 1.68 down 1.59E-‐02 RRSL_04418 o c hypothetical protein638718963 9.48 10.4 1.71 down 1.39E-‐02 RRSL_04419 o c hypothetical protein638718964 9.85 9.23 1.69 up 2.43E-‐01 RRSL_04420 Serine protease( EC:3.4.21.-‐ )638718965 11.41 10.98 1.49 up 1.56E-‐01 RRSL_04421 o c L-‐lactate permease638718966 10.08 10.06 1.12 up 5.36E-‐01 RRSL_04422 o c Transporter638718967 8.9 9.39 1.27 down 1.26E-‐01 RRSL_04423 o c Transporter638718968 10.22 11.36 1.99 down 6.04E-‐03 RRSL_04424 o c Topoisomerase IV subunit A638718969 11.42 11.81 1.18 down 1.46E-‐02 RRSL_04425 o Soluble lytic murein transglycosylase( EC:3.2.1.-‐ )638718971 9.98 10.01 1.08 up 1.85E-‐01 RRSL_04427 o hypothetical protein638718972 9.43 9.92 1.27 down 1.14E-‐01 RRSL_04428 o c uup Uup638718973 11.75 11.29 1.52 up 6.60E-‐03 RRSL_04429 o c hypothetical protein638718974 11.09 10.56 1.6 up 1.15E-‐02 RRSL_04430 o c Glutamate/aspartate-‐binding protein

638718975 11.05 11.14 1.04 up 8.87E-‐01 RRSL_04431 o c hypothetical protein638718977 9.45 9.37 1.17 up 9.60E-‐02 RRSL_04433 hypothetical protein638718978 11.78 12.85 1.9 down 9.11E-‐02 RRSL_RNA039 ( tRNA )638718979 10.15 10.34 1.04 down 7.73E-‐01 RRSL_04434 o DNA integration/recombination/invertion protein638718980 9.32 9.62 1.11 down 4.80E-‐01 RRSL_04435 o hypothetical protein638718981 7.07 7.81 1.51 down 1.25E-‐02 RRSL_04436 o hypothetical protein638718984 6.98 7.93 1.76 down 5.46E-‐02 RRSL_04441 o hypothetical protein638718985 12.97 12.76 1.28 up 2.59E-‐01 RRSL_04443 o hypothetical protein638718986 12.51 12.59 1.05 up 8.33E-‐01 RRSL_04444 o hypothetical protein638718987 12.23 12.37 1 up 9.92E-‐01 RRSL_04445 o VgrG protein638718988 12.84 11.99 1.99 up 5.65E-‐03 RRSL_04446 hypothetical protein638718989 12.54 11.78 1.87 up 1.81E-‐02 RRSL_04447 hypothetical protein638718991 13.05 12.29 1.87 up 1.91E-‐01 RRSL_04449 o c ATP-‐dependent RNA helicase638718994 10.63 11.38 1.53 down 7.60E-‐02 RRSL_04452 o c Integral membrane protein638718995 12.37 12.86 1.27 down 1.54E-‐01 RRSL_04454 o c Threonine dehydratase( EC:4.2.1.16 )638718996 10.33 11.34 1.82 down 1.58E-‐02 RRSL_04453 o c Thymidylate synthase( EC:2.1.1.45 )638718997 7.85 8.86 1.82 down 8.64E-‐03 RRSL_04455 o c Dihydrofolate reductase( EC:1.5.1.3 )638718998 12.62 13.23 1.38 down 4.34E-‐02 RRSL_04456 o c PmbA protein638718999 12.82 12.45 1.43 up 1.85E-‐01 RRSL_04457 o c hypothetical protein638719001 12.04 11.02 2.24 up 6.01E-‐02 RRSL_04460 o c Oligoribonuclease( EC:3.1.-‐ )638719002 11.49 12.41 1.72 down 1.09E-‐03 RRSL_04459 o c potential CaaX prenyl protease 1( EC:3.4.24.-‐ )638719003 10.64 11.5 1.65 down 4.22E-‐02 RRSL_04461 o c GTPase( EC:3.6.1.-‐ )638719004 7.35 8.4 1.88 down 4.06E-‐02 RRSL_04462 o c hypothetical protein638719005 10.46 11.09 1.4 down 1.90E-‐02 RRSL_04463 o c CbiB protein638719006 10.99 11.52 1.31 down 9.83E-‐02 RRSL_04464 o c Conserved hypothetical protein638719007 15.44 16 1.34 down 3.62E-‐02 RRSL_04465 o c LSU ribosomal protein L19P638719008 13 14.07 1.91 down 3.05E-‐02 RRSL_04466 o c hypothetical protein( EC:2.1.1.31 )638719010 9.85 9.7 1.22 up 3.82E-‐01 RRSL_04468 o c L-‐sorbosone dehydrogenase (FAD)( EC:1.2.99.-‐ )638719011 9.12 9.12 1.1 up 6.80E-‐01 RRSL_04470 o c hypothetical protein638719013 12.52 13.33 1.59 down 2.81E-‐02 RRSL_04472 o c hypothetical protein638719014 8.23 9.1 1.66 down 5.92E-‐03 RRSL_04473 o c Transporter638719015 10.97 11.87 1.69 down 3.82E-‐02 RRSL_04474 o c Leucine-‐responsive regulatory protein638719019 9.84 9.1 1.84 up 4.27E-‐02 RRSL_04478 o c hypothetical signal protein638719020 8.73 8.39 1.4 up 3.44E-‐01 RRSL_04479 o c probable transmembrane ABC transporter protein638719021 8.57 7.77 1.93 up 5.66E-‐02 RRSL_04480 o c ABC transporter ATP-‐binding protein638719023 9.46 10.3 1.62 down 4.21E-‐02 RRSL_04482 Predicted O-‐linked N-‐acetylglucosamine transferase638719024 11.58 13.19 2.77 down 5.91E-‐02 RRSL_04484 o c Lysine-‐specific permease638719025 8.33 7.59 1.84 up 3.56E-‐02 RRSL_04485 o probable DNA damage inducible protein F638719026 10.79 10.38 1.46 up 1.84E-‐01 RRSL_04486 hypothetical protein638719027 9.56 9.59 1.08 up 7.89E-‐01 RRSL_04487 o c hypothetical protein638719028 8.09 8.42 1.14 down 5.53E-‐01 RRSL_04489 o c HmsH638719029 8.59 8.3 1.35 up 2.61E-‐01 RRSL_04490 o c HmsF protein638719030 8.64 8.03 1.69 up 1.78E-‐01 RRSL_04491 o c HmsR638719031 8.04 8.3 1.08 down 5.87E-‐01 RRSL_04492 o c hypothetical protein638719032 9.31 9.82 1.29 down 2.62E-‐01 RRSL_04493 o c Type I secretion outer membrane protein638719033 9.78 10.47 1.46 down 1.09E-‐01 RRSL_04494 o c Type I secretion adaptor protein (HlyD family)638719034 8.68 9.62 1.74 down 1.78E-‐01 RRSL_04495 o c Type I protein secretion ATP-‐binding protein / Type I protein secretion transmembrane protein subunit / Type I secretion processing peptidase638719035 11.61 11.28 1.38 up 7.49E-‐03 RRSL_04496 o Hemolysin-‐type Calcium-‐binding protein -‐ RTX toxin638719037 12.94 12.9 1.13 up 3.20E-‐02 RRSL_04497 o GspF-‐related protein638719038 7.07 7.15 1.04 up 7.21E-‐01 RRSL_04499 o GspE-‐related protein638719039 8.03 7.97 1.15 up 3.03E-‐01 RRSL_04500 o hypothetical protein638719040 8.44 8.63 1.03 down 9.09E-‐01 RRSL_04501 o hypothetical protein638719041 7.96 8.04 1.04 up 7.67E-‐01 RRSL_04502 o transposase COG4584638719042 12.08 11.76 1.38 up 1.10E-‐01 RRSL_04503 o putative transposase638719043 11.98 11.85 1.21 up 1.38E-‐01 RRSL_04504 o Putative transposase638719044 10.35 10.59 1.07 down 7.78E-‐01 RRSL_04505 hypothetical protein638719045 11.01 10.27 1.84 up 8.77E-‐03 RRSL_04506 hypothetical protein638719046 9.43 10.09 1.43 down 9.17E-‐03 RRSL_04507 hypothetical protein638719047 9.42 9.01 1.47 up 2.02E-‐01 RRSL_04508 hypothetical protein638719048 9.25 9.12 1.21 up 7.40E-‐02 RRSL_04509 Transcriptional regulator, AraC family638719049 8.71 8.53 1.25 up 1.83E-‐01 RRSL_04510 4-‐carboxymuconolactone decarboxylase638719050 13.59 12.95 1.72 up 7.46E-‐02 RRSL_04511 o c LacX protein638719051 10.43 10.96 1.31 down 2.55E-‐01 RRSL_04512 o c hypothetical protein638719052 9.61 9.65 1.07 up 7.75E-‐01 RRSL_04513 o c DNA polymerase IV( EC:2.7.7.7 )638719053 9.87 10.86 1.81 down 2.49E-‐02 RRSL_04514 o c Amino acid permease638719054 9.01 9.68 1.44 down 4.88E-‐02 RRSL_04515 o c hypothetical protein638719055 12.9 13.36 1.25 down 5.27E-‐01 RRSL_04516 o c hypothetical protein638719056 8.83 9.53 1.47 down 1.79E-‐01 RRSL_04517 o c 2,4-‐dihydroxyhept-‐2-‐ene-‐1,7-‐dioic acid aldolase( EC:4.1.2.-‐,EC:4.1.2.20 )638719057 10.8 11.74 1.74 down 1.57E-‐02 RRSL_04518 o Transcriptional regulator, MarR family638719058 11.33 11.52 1.03 down 7.67E-‐01 RRSL_04519 o c Exodeoxyribonuclease III( EC:3.1.11.2 )638719059 9.21 9.51 1.12 down 3.27E-‐01 RRSL_04520 o c Cytosine deaminase( EC:3.5.4.1 )638719062 11.06 11.89 1.61 down 1.95E-‐02 RRSL_04523 o c transcriptional regulator/response regulator LuxR family638719063 9.93 9.75 1.25 up 7.93E-‐02 RRSL_04524 o c Sensor protein fixL( EC:2.7.3.-‐ )638719069 16.74 16.86 1.01 up 8.33E-‐01 RRSL_04530 o c granule-‐associated protein638719070 9.2 9.03 1.24 up 2.03E-‐01 RRSL_04531 o c Deacetylase638719071 12.34 12.42 1.05 up 7.40E-‐01 RRSL_04532 Transporter, drug/metabolite exporter family

638719072 9.06 9.8 1.51 down 1.73E-‐02 RRSL_04533 o c hypothetical protein638719073 12.61 13.32 1.48 down 1.43E-‐02 RRSL_04534 o c D-‐alanyl-‐D-‐alanine-‐endopeptidase( EC:3.4.99.-‐ )638719074 11.46 9.13 5.55 up 5.82E-‐02 RRSL_04535 o c Transcriptional regulator, IclR family638719075 11.38 11.72 1.14 down 4.51E-‐01 RRSL_04536 o c Cysteine-‐rich domain of 2-‐hydroxy-‐acid oxidase GlcF homolog638719076 10.14 10.15 1.1 up 6.63E-‐01 RRSL_04537 o c iron-‐sulfur cluster-‐binding protein638719077 8.98 9.71 1.51 down 2.00E-‐01 RRSL_04538 o c hypothetical protein638719078 12.41 13.01 1.37 down 7.06E-‐02 RRSL_04539 o c hypothetical protein638719079 12.05 12.09 1.07 up 7.01E-‐01 RRSL_04541 o c Arginine-‐tRNA-‐protein transferase( EC:2.3.2.8 )638719080 10.69 11.13 1.23 down 4.17E-‐01 RRSL_04542 o c Leucyl/phenylalanyl-‐tRNA-‐-‐protein transferase( EC:2.3.2.-‐,EC:2.3.2.6 )638719081 9.84 10.76 1.71 down 1.52E-‐01 RRSL_04543 o c Mutator mutT protein (7,8-‐dihydro-‐8-‐oxoguanine-‐triphosphatase)( EC:3.6.1.-‐ )638719082 14.31 14.76 1.23 down 2.54E-‐01 RRSL_RNA043 ( tRNA )638719083 10.18 11.18 1.81 down 1.06E-‐02 RRSL_04544 o c Dihydroorotate dehydrogenase( EC:1.3.3.1 )638719084 10.15 11.23 1.92 down 5.71E-‐02 RRSL_04545 o c hypothetical protein638719085 10.54 10.54 1.1 up 1.95E-‐01 RRSL_04546 o c Kup system potassium uptake protein638719089 8.56 9.22 1.44 down 6.35E-‐02 RRSL_04549 o c ATP-‐dependent helicase, DinG family638719090 14.27 14.63 1.17 down 2.04E-‐01 RRSL_04552 o c transmembrane protein638719091 13.64 13.8 1.01 down 9.02E-‐01 RRSL_04551 o c Ribosomal large subunit pseudouridine synthase D( EC:4.2.1.70 )638719092 9.64 10.36 1.49 down 1.35E-‐01 RRSL_04553 o c hypothetical cytosolic protein638719093 10.87 11.14 1.09 down 5.57E-‐01 RRSL_04554 o c hypothetical protein638719098 10.15 10.9 1.52 down 7.91E-‐03 RRSL_04559 o c tRNA-‐dihydrouridine synthase638719099 11.12 11.82 1.47 down 4.68E-‐02 RRSL_04560 o c Fe-‐S OXIDOREDUCTASE( EC:1.8.-‐ )638719100 10.95 10.92 1.13 up 4.55E-‐01 RRSL_04561 o 3-‐ketoacyl-‐CoA thiolase( EC:2.3.1.16,EC:2.3.1.9 )638719101 7.92 8.23 1.12 down 5.97E-‐01 RRSL_04562 o c hypothetical protein638719102 10.86 11.46 1.38 down 6.18E-‐02 RRSL_04563 o c Cystathionine beta-‐lyase( EC:4.4.1.8 )638719103 10.89 11.51 1.4 down 8.69E-‐03 RRSL_04564 hypothetical protein638719105 8.54 9.54 1.82 down 5.93E-‐03 RRSL_04566 o c Acetylornithine deacetylase( EC:3.5.1.16 )638719106 10.07 10.38 1.12 down 5.76E-‐01 RRSL_04568 o c Transcription-‐repair coupling factor638719107 9.88 10.77 1.69 down 2.14E-‐02 RRSL_04569 o c 2-‐C-‐methyl-‐D-‐erythritol 2,4-‐cyclodiphosphate synthase( EC:4.6.1.12 )638719108 10.84 10 1.98 up 8.63E-‐02 RRSL_04570 o c AhpD protein638719110 9.44 10.11 1.44 down 6.53E-‐03 RRSL_04573 o c Osmolarity sensor protein envZ( EC:2.7.3.-‐ )638719111 11.68 12.7 1.85 down 8.01E-‐03 RRSL_04574 o c RisA638719112 13.34 12.73 1.67 up 3.75E-‐02 RRSL_04575 o c hypothetical protein638719113 11.84 11.4 1.5 up 5.37E-‐02 RRSL_04576 o c hypothetical cytosolic protein638719114 11.65 11.14 1.57 up 1.29E-‐02 RRSL_04577 o c GLUCOSE-‐6-‐PHOSPHATE DEHYDROGENASE (coenzyme F420)( EC:1.1.99.-‐ )638719115 9.94 10.61 1.45 down 1.04E-‐01 RRSL_04578 o c Phytoene synthase( EC:2.5.1.32 )638719117 7.73 8.43 1.47 down 3.86E-‐03 RRSL_04580 o c transmembrane protein drug efflux protein638719119 9.81 8.68 2.42 up 1.11E-‐01 RRSL_04581 hypothetical protein638719120 7.25 7.4 1.01 down 9.74E-‐01 RRSL_04582 o c hypothetical protein638719121 8.87 9.27 1.2 down 2.01E-‐01 RRSL_04583 o c tRNA (5-‐aminomethyl-‐2-‐thiouridylate) methyltransferase / tRNA (5-‐carboxymethylaminomethyl-‐2-‐thiouridylate) oxidase TrmC( EC:2.1.1.-‐ )638719122 14.99 15.77 1.56 down 9.03E-‐03 RRSL_04584 o c Trigger factor, ppiase( EC:5.2.1.8 )638719124 14.63 14.37 1.32 up 3.19E-‐02 RRSL_04586 o c clpX ClpX638719125 14.03 14.44 1.2 down 3.18E-‐01 RRSL_04587 o c ATP-‐dependent protease LA( EC:3.4.21.53 )638719126 9.57 9.52 1.14 up 5.67E-‐01 RRSL_04588 o c DNA-‐binding protein HU638719127 14.12 15.35 2.13 down 5.15E-‐02 RRSL_RNA041 ( tRNA )638719130 8.97 9.21 1.07 down 6.25E-‐01 RRSL_04277 Hypothetical Protein638719131 8.35 9.16 1.58 down 5.30E-‐02 RRSL_04278 o Hypothetical Protein638719132 16.16 16.31 1 down 9.75E-‐01 RRSL_04279 Hypothetical Protein638719133 16.58 16.82 1.07 down 2.18E-‐01 RRSL_04280 Hypothetical Protein638719134 13.13 13.25 1.01 up 9.73E-‐01 RRSL_04281 o Hypothetical Protein638719135 9.95 9.74 1.27 up 1.92E-‐01 RRSL_04282 o Hypothetical Protein638719136 8.31 8.6 1.1 down 3.78E-‐01 RRSL_04283 o Adenylylsulfate kinase( EC:2.7.1.25 )638719137 10.53 9.77 1.86 up 2.66E-‐02 RRSL_04285 o Antibiotic/siderophore biosynthesis protein638719138 8.86 9.33 1.26 down 1.53E-‐01 RRSL_04286 o Probable Na+ driven multidrug efflux pump638719139 11.01 11.6 1.37 down 4.27E-‐01 RRSL_04287 o 4'-‐phosphopantetheinyl transferase( EC:2.7.8.-‐ )638719140 13.2 13.72 1.3 down 2.70E-‐01 RRSL_04288 o Endoglucanase precursor( EC:3.2.1.4 )638719142 13.39 13.08 1.37 up 1.14E-‐03 RRSL_04290 Hypothetical Protein638719143 10.48 10.71 1.06 down 7.98E-‐01 RRSL_04292 Hypothetical Protein638719144 13.42 13.94 1.29 down 4.24E-‐02 RRSL_04294 probable transcription regulator protein638719146 13.11 14.15 1.87 down 3.40E-‐03 RRSL_04296 o c Glucosamine-‐1-‐phosphate acetyltransferase / UDP-‐N-‐acetylglucosamine pyrophosphorylase( EC:2.3.1.-‐,EC:2.7.7.23 )638719148 7.9 7.94 1.07 up 6.67E-‐01 RRSL_04298 o 2-‐dehydropantoate 2-‐reductase( EC:1.1.1.169 )638719149 9.17 9.45 1.1 down 6.11E-‐01 RRSL_04299 o UbiA prenyltransferase family protein638719150 8.78 9.77 1.8 down 4.35E-‐03 RRSL_04300 o L-‐gulonolactone oxidase( EC:1.1.3.8 )638719151 10.3 10.91 1.38 down 2.23E-‐01 RRSL_04301 o NADH-‐ubiquinone oxidoreductase 39-‐40 kDa subunit homolog638719152 9.74 10.56 1.6 down 3.98E-‐02 RRSL_04302 o NADPH-‐dependent glutamate synthase beta chain and related oxidoreductases638719153 10.05 10.2 1 down 9.78E-‐01 RRSL_04303 o Hypothetical Protein638719154 7.25 7.56 1.12 down 2.99E-‐01 RRSL_04304 o c oprM OprM638719155 8.64 8.37 1.32 up 1.18E-‐01 RRSL_04305 o c ABC-‐type multidrug transport system, permease component638719156 7.76 7.47 1.34 up 1.99E-‐01 RRSL_04306 o c ABC transporter ATP-‐binding protein638719158 7.69 8.35 1.42 down 2.89E-‐02 RRSL_04308 o c Transcriptional regulator, TetR family638719159 8.22 8.1 1.19 up 3.02E-‐01 RRSL_04309 o c piperideine-‐6-‐carboxylate dehydrogenase( EC:1.2.1.-‐ )638719160 8.09 8.47 1.18 down 1.07E-‐01 RRSL_04310 o c Transcriptional regulatory protein638719161 10.31 10.48 1.02 down 9.33E-‐01 RRSL_04311 o c Ornithine aminotransferase( EC:2.6.1.13 )638719162 9.34 9.53 1.04 down 8.87E-‐01 RRSL_04312 o c Arginase( EC:3.5.3.1 )638719163 12.28 12.74 1.24 down 5.07E-‐02 RRSL_04313 o c Dihydroneopterin aldolase( EC:4.1.2.25 )638719164 10.93 10.77 1.23 up 5.71E-‐01 RRSL_04314 o c Hypothetical cytosolic protein638719165 10.45 10.08 1.42 up 3.92E-‐01 RRSL_04317 o c AmpG protein

638719166 10.44 9.03 2.93 up 7.74E-‐02 RRSL_04316 o Zinc metalloprotease( EC:3.4.24.-‐ )638719167 10.74 9.9 1.97 up 1.67E-‐01 RRSL_04318 o c Transporter, drug/metabolite exporter family638719168 8.02 7.43 1.66 up 1.48E-‐01 RRSL_04319 o c Hypothetical Protein638719169 7.86 7.95 1.04 up 8.66E-‐01 RRSL_04320 o c Transcriptional regulator, MarR family638719170 9.94 9.82 1.2 up 6.59E-‐01 RRSL_04321 o c Hypothetical Protein638719171 10.5 9.48 2.24 up 1.10E-‐01 RRSL_04322 o c Hypothetical Protein638719172 10.8 12 2.08 down 6.32E-‐02 RRSL_04323 o c Integral membrane protein638719174 9.86 9.36 1.55 up 1.34E-‐01 RRSL_04325 o Transcriptional regulators, LysR family638719175 9.23 7.86 2.84 up 1.92E-‐01 RRSL_04326 o Hypothetical Protein638719177 11.23 11.94 1.48 down 3.66E-‐03 RRSL_04328 o c Hypothetical Transmembrane Protein638719178 13.72 13.46 1.32 up 1.67E-‐01 RRSL_04329 o c Orotate phosphoribosyltransferase( EC:2.4.2.10 )638719179 11.98 12.11 1.01 up 9.58E-‐01 RRSL_04331 o c Hypothetical protein638719180 10.69 11.48 1.57 down 8.89E-‐03 RRSL_04332 o c Diaminopimelate epimerase( EC:5.1.1.7 )638719181 10.29 11 1.49 down 1.04E-‐02 RRSL_04333 o c Lipid A biosynthesis lauroyl acyltransferase( EC:2.3.1.-‐ )638719182 12 11.9 1.18 up 3.23E-‐01 RRSL_04334 o c Lipid A biosynthesis (KDO) 2-‐(lauroyl)-‐lipid IVA acyltransferase( EC:2.3.1.-‐ )638719183 13.73 13.85 1.02 up 8.29E-‐01 RRSL_04335 o c S-‐adenosylmethionine synthetase( EC:2.5.1.6 )638719184 10.37 9.83 1.6 up 8.03E-‐02 RRSL_04336 o c Hypothetical Protein638719185 9.68 9.32 1.41 up 6.46E-‐02 RRSL_04337 Hypothetical Protein638719186 8.66 8.15 1.57 up 2.69E-‐02 RRSL_04339 o c PAP2 family protein638719187 10.36 9.22 2.42 up 9.15E-‐02 RRSL_04340 o c Transporter638719188 9.43 9.64 1.04 down 7.94E-‐01 RRSL_04341 o c Glutathione S-‐transferase( EC:2.5.1.18 )638719189 9.59 9.22 1.42 up 1.25E-‐01 RRSL_04342 o Leucine-‐responsive regulatory protein638719190 8.42 7.55 2.01 up 1.89E-‐01 RRSL_04343 RNA polymerase sigma factor SigJ638719191 8.64 7.82 1.95 up 1.06E-‐01 RRSL_04344 o probable haemagglutinin-‐related protein638719192 13.68 12.88 1.92 up 1.25E-‐02 RRSL_04345 o c Hypothetical Protein638719193 10.89 10.57 1.37 up 2.99E-‐01 RRSL_04346 o putative DNA-‐binding protein638719194 12.73 11.87 2.01 up 1.01E-‐01 RRSL_04347 o Hypothetical protein638719195 9.4 8.91 1.55 up 9.81E-‐02 RRSL_04348 o Polyethylene glycol dehydrogenase( EC:1.1.99.20 )638719196 7.6 8.57 1.77 down 2.56E-‐02 RRSL_04349 Hypothetical Protein638719198 8.44 8.94 1.28 down 7.42E-‐02 RRSL_04351 o c Acyl-‐CoA dehydrogenase( EC:1.3.99.3 )638719199 9.93 11.03 1.94 down 6.91E-‐03 RRSL_04352 o c Acetyltransferase( EC:2.3.1.-‐ )638719200 12.31 13.18 1.65 down 3.16E-‐03 RRSL_04353 o Hypothetical Protein638719201 10.92 11.78 1.65 down 6.56E-‐02 RRSL_04354 o probable conserved hypothetical protein638719202 13.05 13.26 1.05 down 6.63E-‐01 RRSL_04355 o Hypothetical Protein638719203 13.56 13.7 1 up 9.88E-‐01 RRSL_04356 o Hypothetical Protein638719204 9.82 10.51 1.47 down 7.51E-‐02 RRSL_04357 o Hypothetical Protein638719209 9.43 8.74 1.78 up 1.46E-‐02 RRSL_04365 o c PhnB protein638719210 9.39 9.44 1.06 up 5.67E-‐01 RRSL_04366 o c Hypothetical Protein638719211 9.73 10.82 1.93 down 1.27E-‐02 RRSL_04367 o c phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase( EC:2.7.1.49,EC:2.7.4.7 )638719212 9.25 9.79 1.32 down 1.86E-‐02 RRSL_04368 o c Hypothetical Protein638719213 9.93 10.63 1.47 down 3.10E-‐03 RRSL_04369 o c Alkaline phosphatase( EC:3.1.3.1 )638719214 9.35 9.85 1.28 down 2.54E-‐02 RRSL_04370 o c Alkaline phosphatase( EC:3.1.3.1 )638719215 13.65 13.85 1.04 down 5.86E-‐01 RRSL_04371 o c Adenosylhomocysteinase( EC:3.3.1.1 )638719216 13.33 13.32 1.11 up 4.44E-‐01 RRSL_04372 o c Integral membrane protein638719217 9.49 10.15 1.43 down 6.52E-‐02 RRSL_04373 o c Methylenetetrahydrofolate reductase( EC:1.5.1.20 )638719218 7.4 8.02 1.39 down 5.61E-‐02 RRSL_04374 o c Hypothetical Protein638719219 9.08 9.17 1.04 up 8.45E-‐01 RRSL_04375 Phosphohydrolase (MutT/nudix family protein)638719220 9.88 9.54 1.39 up 7.18E-‐02 RRSL_04377 o c 5-‐formyltetrahydrofolate cyclo-‐ligase( EC:6.3.3.2 )638719222 9.05 8.27 1.89 up 8.98E-‐02 RRSL_04378 o c NADH-‐ubiquinone oxidoreductase( EC:1.6.5.3,EC:1.6.99.3 )638719223 8.75 7.76 2.19 up 9.66E-‐02 RRSL_04379 Hypothetical Protein638719226 9.36 9.17 1.25 up 9.06E-‐02 RRSL_04382 o c Glutamate/aspartate-‐binding protein638719227 8.79 9.1 1.12 down 6.10E-‐01 RRSL_04383 o c Hypothetical cytosolic protein638719228 7.55 8.12 1.34 down 1.13E-‐01 RRSL_04384 o c COG0161 adenosylmethionine 8-‐amino-‐7-‐oxonoanoate aminotransferase( EC:2.6.1.-‐ )638719229 8.07 8.13 1.06 up 8.29E-‐01 RRSL_04385 o c Transcriptional regulator, RpiR family638719231 11.56 11.24 1.38 up 6.29E-‐02 RRSL_04387 o Hypothetical Protein638719233 7.95 8.56 1.38 down 1.72E-‐01 RRSL_04047 Core protein638719234 8.19 7.59 1.68 up 5.52E-‐02 RRSL_04048 o Transposase638719235 8.44 8.43 1.11 up 7.32E-‐01 RRSL_04049 o Transposase638719236 13.43 13.02 1.47 up 9.12E-‐04 RRSL_04050 Hypothetical Protein638719238 11.06 10.25 1.93 up 3.61E-‐02 RRSL_04053 Hypothetical Protein638719240 16.35 16.61 1.08 down 3.83E-‐01 RRSL_04058 Hypothetical Protein638719241 16.19 16.21 1.08 up 6.14E-‐01 RRSL_04059 Hypothetical Protein638719242 14.23 14.25 1.09 up 4.99E-‐01 RRSL_04060 Hypothetical Protein638719243 12.01 12.94 1.73 down 1.07E-‐02 RRSL_04061 Hypothetical Protein638719245 11.37 12.02 1.42 down 5.17E-‐03 RRSL_04063 Short chain dehydrogenase638719246 8.51 9.34 1.62 down 4.72E-‐03 RRSL_04064 Hypothetical Protein638719247 9.22 8.59 1.71 up 1.05E-‐01 RRSL_04065 Hypothetical Protein638719248 9 9.71 1.48 down 2.43E-‐01 RRSL_04066 o c Glutathione S-‐transferase( EC:2.5.1.18 )638719249 8.75 8.84 1.03 up 8.78E-‐01 RRSL_04067 o c Probable transmembrane methyl-‐accepting chemotaxis protein638719253 8.38 8.98 1.38 down 1.49E-‐02 RRSL_04071 o c Paraquat-‐inducible protein A638719254 10.23 10.39 1.01 down 9.07E-‐01 RRSL_04073 o c Paraquat-‐inducible protein A638719255 9.88 10.09 1.05 down 5.49E-‐01 RRSL_04074 o c Paraquat-‐inducible protein B638719256 8.62 9.35 1.5 down 2.71E-‐02 RRSL_04075 o c Hypothetical Protein638719257 9.91 10.57 1.44 down 1.38E-‐01 RRSL_04076 o c Transcriptional regulator, GntR family / AMINOTRANSFERASE CLASS-‐I( EC:2.6.1.-‐ )638719260 13.26 14.35 1.92 down 2.16E-‐02 RRSL_04079 Hypothetical Protein638719262 10.05 9.93 1.19 up 4.81E-‐01 RRSL_04081 o c Hypothetical Protein

638719263 11.45 12.11 1.43 down 4.32E-‐03 RRSL_04082 o c Hypothetical Protein638719264 9.39 8.89 1.57 up 2.50E-‐01 RRSL_04083 o c Hypothetical Protein638719265 10.63 9.98 1.73 up 2.69E-‐02 RRSL_04084 o c sensory transduction protein638719266 11.17 10.96 1.28 up 1.25E-‐01 RRSL_04085 o c Hypothetical Protein638719267 9.53 10.24 1.48 down 1.31E-‐01 RRSL_04086 o c Transcriptional regulator, MarR family638719268 8.21 8.68 1.26 down 2.38E-‐01 RRSL_04088 Salicylate hydroxylase( EC:1.14.13.1 )638719269 8.34 9.19 1.63 down 4.88E-‐02 RRSL_04087 o c Glutamyl-‐tRNA(Gln) amidotransferase subunit A( EC:6.3.5.-‐ )638719270 8.52 8.53 1.1 up 4.25E-‐01 RRSL_04089 o c Sensor protein( EC:2.7.3.-‐ )638719271 8.3 8.67 1.17 down 2.88E-‐01 RRSL_04090 PhnM protein638719272 9.2 9.22 1.09 up 5.18E-‐01 RRSL_04091 Hypothetical Protein638719273 8.94 8.61 1.39 up 2.98E-‐02 RRSL_04092 o c Hypothetical Protein638719274 14.19 13.85 1.39 up 2.20E-‐03 RRSL_04093 o c Hypothetical Protein638719275 10.91 10.15 1.87 up 2.75E-‐01 RRSL_04094 o c mosC MosC638719276 9.24 9.25 1.09 up 3.32E-‐01 RRSL_04095 o c D-‐alanyl-‐meso-‐diaminopimelate endopeptidase( EC:3.4.-‐ )638719280 9.31 9.52 1.05 down 8.41E-‐01 RRSL_04099 o c Hypothetical Protein638719281 9.76 10.72 1.76 down 6.41E-‐02 RRSL_04100 o c SUA5 protein638719282 10 11.19 2.06 down 5.30E-‐02 RRSL_04101 o c Phosphoribosylaminoimidazole carboxylase NCAIR mutase subunit( EC:4.1.1.21 )638719283 10.62 11.75 1.99 down 2.62E-‐02 RRSL_04102 o c Phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit( EC:4.1.1.21 )638719284 10.71 11.84 2 down 3.18E-‐02 RRSL_04103 o c Hypothetical Protein638719288 9.98 9.53 1.51 up 1.48E-‐01 RRSL_04107 o c rarD RarD638719289 8.8 8.83 1.08 up 8.03E-‐01 RRSL_04108 o c Hypothetical Protein638719290 10.94 11.2 1.09 down 4.64E-‐01 RRSL_04109 o c Hypothetical Protein638719292 13.06 13.81 1.53 down 4.08E-‐03 RRSL_04111 o c Hypothetical protein638719294 10.67 11.79 1.97 down 2.09E-‐02 RRSL_04113 o c Hypothetical Protein638719295 9.38 10.28 1.69 down 2.87E-‐02 RRSL_04114 o c Alpha/beta hydrolase638719296 9.09 10.03 1.74 down 4.13E-‐02 RRSL_04115 o c Hypothetical Protein638719297 7.75 8.28 1.31 down 1.19E-‐01 RRSL_04116 o c Zinc metalloprotease( EC:3.4.24.-‐ )638719298 11.35 11.87 1.3 down 8.84E-‐02 RRSL_04117 o c Molybdenum cofactor biosynthesis protein C638719299 13.21 13.34 1.01 up 9.78E-‐01 RRSL_04118 o c Hypothetical Protein638719300 16.09 16.29 1.04 down 7.49E-‐01 RRSL_04119 o c pilA PilA638719301 11.35 11.41 1.06 up 7.32E-‐01 RRSL_04120 o plpA PlpA638719302 12.25 11.95 1.36 up 2.76E-‐02 RRSL_04121 o c Integral membrane protein638719303 13.42 14.14 1.49 down 1.74E-‐01 RRSL_04122 o c Succinyl-‐CoA synthetase alpha chain( EC:6.2.1.5 )638719304 13.62 14.18 1.33 down 1.52E-‐01 RRSL_04123 o c Succinyl-‐CoA synthetase beta chain( EC:6.2.1.5 )638719305 12.41 12.59 1.03 down 8.14E-‐01 RRSL_04124 o c Hypothetical Protein638719306 11.54 12.75 2.1 down 5.17E-‐02 RRSL_04126 o c RecA protein638719307 8.73 8.72 1.11 up 3.25E-‐01 RRSL_04127 o c Sensor protein qseC( EC:2.7.3.-‐ )638719312 9.01 9.64 1.41 down 2.64E-‐02 RRSL_04131 o c 2-‐Octaprenyl-‐6-‐metoxyphenol hydroxylase and related FAD-‐dependent oxidoreductases638719313 9.15 8.74 1.47 up 1.80E-‐01 RRSL_04133 o c Transcriptional regulatory protein638719314 8.74 9.27 1.3 down 5.41E-‐02 RRSL_04135 o c Transcriptional regulators, LysR family638719315 8.69 8.3 1.45 up 1.11E-‐01 RRSL_04136 o c Pirin638719316 8.95 9.21 1.09 down 7.74E-‐01 RRSL_04137 o c Serine protease( EC:3.4.21.-‐ )638719317 11.43 11.68 1.08 down 8.33E-‐01 RRSL_04138 o c ATP-‐dependent RNA helicase RhlE638719318 8.76 8.45 1.37 up 1.51E-‐01 RRSL_04139 o c Transcriptional regulator, TetR family638719319 9.19 8.5 1.77 up 9.52E-‐02 RRSL_04140 o c Acyl-‐CoA dehydrogenase( EC:1.3.99.-‐ )638719320 8.44 8.33 1.19 up 2.51E-‐01 RRSL_04141 o c 3-‐oxoacyl-‐[acyl-‐carrier protein] reductase( EC:1.1.1.100 )638719321 8.77 8.26 1.57 up 8.52E-‐02 RRSL_04142 MaoC-‐like protein638719322 8.59 8.69 1.03 up 8.45E-‐01 RRSL_04144 3-‐ketoacyl-‐CoA thiolase( EC:2.3.1.16 )638719323 10.62 9.44 2.49 up 1.25E-‐01 RRSL_04146 Long-‐chain-‐fatty-‐acid-‐-‐CoA ligase( EC:6.2.1.3 )638719324 14.74 13.74 2.2 up 1.01E-‐01 RRSL_04147 Outer membrane protein638719327 12.03 12.33 1.12 down 1.84E-‐01 RRSL_04150 o c COG0621, tRNA 2-‐methylthioadenosine synthase638719328 12.2 12.66 1.24 down 5.64E-‐02 RRSL_04151 o c PhoH-‐like protein638719329 12.37 12.95 1.36 down 1.28E-‐01 RRSL_04152 o c Hypothetical Metal-‐Binding Protein638719330 7.87 7.89 1.08 up 8.45E-‐01 RRSL_04153 Hypothetical Protein638719331 13.07 12.22 1.99 up 9.32E-‐04 RRSL_04155 o c corC CorC638719333 12.39 13.31 1.72 down 3.37E-‐03 RRSL_04157 o c Glycyl-‐tRNA synthetase alpha chain( EC:6.1.1.14 )638719334 8.07 9.15 1.92 down 2.34E-‐02 RRSL_04158 o c signal peptide638719336 9.9 10.99 1.93 down 2.78E-‐02 RRSL_04160 o c Phosphatase family protein638719337 11.4 11.34 1.15 up 1.52E-‐01 RRSL_04161 o c N-‐acylhomoserine lactone synthase( EC:2.3.1.-‐ )638719338 7.95 8.33 1.18 down 3.44E-‐01 RRSL_04162 o c hypothetical protein638719339 6.6 6.88 1.1 down 5.70E-‐01 RRSL_04163 Zinc metalloprotease( EC:3.4.24.-‐ )638719340 10.21 10.02 1.26 up 4.09E-‐01 RRSL_04164 o c Sensory transduction protein kinase( EC:2.7.3.-‐ )638719341 9.44 9.82 1.18 down 1.63E-‐01 RRSL_04165 o c Two-‐component response regulator638719342 9.42 9.58 1.01 down 9.31E-‐01 RRSL_04167 Isochorismatase( EC:3.3.2.1 )638719343 9.43 9.42 1.11 up 7.64E-‐01 RRSL_04168 o probable hypothetical protein638719345 9.89 9.66 1.3 up 3.56E-‐01 RRSL_04170 o c ABC transporter substrate-‐binding protein638719346 8.01 7.86 1.23 up 6.17E-‐02 RRSL_04171 o c Transcriptional regulatory protein638719347 8.93 8.56 1.42 up 8.77E-‐03 RRSL_04172 Hypothetical Protein638719348 7.5 7.46 1.14 up 4.35E-‐01 RRSL_04173 o c Type I restriction-‐modification system restriction subunit( EC:3.1.21.3 )638719350 9.77 8.83 2.11 up 8.21E-‐02 RRSL_04175 o c Type I restriction-‐modification system methylation subunit638719351 10.69 9.96 1.82 up 8.80E-‐03 RRSL_04176 o c AAU3 protein precursor638719355 9.52 8.74 1.9 up 3.99E-‐02 RRSL_04181 Hypothetical Protein638719356 9.82 10.01 1.04 down 8.54E-‐01 RRSL_04182 o Shikimate kinase( EC:2.7.1.71 )638719357 10.87 10.87 1.11 up 7.49E-‐01 RRSL_04183 o c Hypothetical Protein638719358 8.04 9.08 1.87 down 9.86E-‐03 RRSL_04184 o c Two component system histidine kinase( EC:2.7.3.-‐ )638719361 10.79 11.46 1.44 down 1.05E-‐02 RRSL_04187 o c hydrolase-‐related protein

638719362 8.12 8.82 1.48 down 4.01E-‐02 RRSL_04188 o c Oxidoreductase( EC:1.-‐ )638719363 9.04 9.68 1.41 down 3.97E-‐02 RRSL_04189 o c Hypothetical Protein638719364 9.16 9.87 1.48 down 8.22E-‐02 RRSL_04190 o c Hypothetical Protein638719365 11.29 11.18 1.19 up 5.62E-‐01 RRSL_04191 o c Periplasmic amino acid binding proteins638719366 7.69 8.46 1.55 down 1.23E-‐03 RRSL_04192 o c Transcriptional regulator, IclR family638719368 8 8.34 1.15 down 3.88E-‐01 RRSL_04194 Hypothetical Protein638719371 11.43 11.64 1.05 down 8.43E-‐01 RRSL_04197 Hypothetical Protein638719372 11.62 11.75 1.01 up 9.58E-‐01 RRSL_04198 Hypothetical Protein638719374 8.94 8.96 1.09 up 4.82E-‐01 RRSL_04201 o c Hypothetical Protein638719375 11.56 10.46 2.36 up 6.80E-‐02 RRSL_04202 o c Endonuclease( EC:3.1.30.-‐ )638719376 10.99 10.94 1.14 up 3.87E-‐01 RRSL_04203 o c Phospho-‐2-‐dehydro-‐3-‐deoxyheptonate aldolase( EC:4.1.2.15 )638719378 11.15 11.33 1.03 down 8.46E-‐01 RRSL_04204 o c putative transport system permease protein638719380 12.71 13.83 1.97 down 1.97E-‐02 RRSL_04206 o c Tol system periplasmic component YbgF638719385 12.33 13.37 1.87 down 3.22E-‐02 RRSL_04211 o c TolQ protein638719386 11.34 11.68 1.15 down 7.34E-‐02 RRSL_04212 o c Short chain acyl-‐CoA thioesterase YbgC638719388 10.78 11.82 1.86 down 3.06E-‐03 RRSL_04215 o c Putative regulatory protein638719389 12.18 12.32 1 down 9.88E-‐01 RRSL_04216 o c putative type-‐4 fimbrial biogenesis PilV-‐related transmembrane protein638719390 11.75 12.04 1.11 down 1.91E-‐01 RRSL_04217 o c Type IV fimbrial biogenesis protein638719391 11.27 11.96 1.46 down 1.23E-‐02 RRSL_04218 o c Probably transmembrane protein638719392 10.92 11.5 1.35 down 7.32E-‐02 RRSL_04219 o c PILI ASSEMBLY PROTEIN, PILY1-‐related protein638719393 10.48 10.96 1.27 down 3.42E-‐02 RRSL_04220 o c probable type-‐4 fimbrial pilin-‐related transmembrane protein638719394 11.39 11.78 1.18 down 5.41E-‐02 RRSL_04221 o c putative type 4 fimbrial pilin related transmembrane protein638719395 7.36 7.71 1.16 down 3.63E-‐01 RRSL_04222 o Probable transmembrane protein638719396 8.55 7.95 1.67 up 2.14E-‐01 RRSL_04223 o c Probably transmembrane protein638719397 8.57 8.05 1.59 up 2.89E-‐01 RRSL_04223_5 o type 4 fimbrial biogenesis pilx-‐related protein638719398 7.27 7.53 1.09 down 7.38E-‐01 RRSL_04224 o c TYPE 4 FIMBRIAL BIOGENESIS, PilY1-‐related protein638719399 7.55 7.6 1.07 up 7.41E-‐01 RRSL_04225 o c putative type-‐4 frimbrial pilin-‐related signal peptide protein638719400 8.83 8.45 1.44 up 3.50E-‐01 RRSL_04226 o c putative type 4 fimbrial pilin related transmembrane protein638719401 11.94 12.32 1.18 down 2.48E-‐01 RRSL_04227 o c Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-‐amino-‐6-‐(5-‐phosphoribosylamino)uracil reductase( EC:1.1.1.193,EC:3.5.4.26 )638719403 12.74 13.67 1.73 down 1.32E-‐02 RRSL_04230 o c 6,7-‐dimethyl-‐8-‐ribityllumazine synthase( EC:2.5.1.9 )638719405 10.37 11.29 1.71 down 7.18E-‐03 RRSL_04232 o c Aspartate aminotransferase( EC:2.6.1.1 )638719406 11.57 12.23 1.44 down 2.70E-‐01 RRSL_04233 o c Protein P7638719407 10.85 11.06 1.04 down 6.90E-‐01 RRSL_04234 o c 3-‐polyprenyl-‐4-‐hydroxybenzoate decarboxylase( EC:4.1.1.-‐ )638719408 9.92 10.08 1.01 down 9.22E-‐01 RRSL_04235 Succinate-‐semialdehyde dehydrogenase (NADP+)( EC:1.2.1.16 )638719409 7.82 8.37 1.33 down 2.16E-‐02 RRSL_04236 o c Hypothetical Protein638719410 11.8 12.08 1.1 down 2.44E-‐01 RRSL_04237 o c Hypothetical Protein638719411 11.73 11.54 1.26 up 5.94E-‐03 RRSL_04238 o c Hypothetical Protein638719412 9.4 9.46 1.06 up 7.36E-‐01 RRSL_04239 o probable conserved hypothetical protein638719415 8.4 9 1.38 down 2.04E-‐02 RRSL_04241 o c NADPH dehydrogenase( EC:1.6.99.1 )638719416 13.8 13.89 1.03 up 8.50E-‐01 RRSL_04242 o c Bacitracin resistance protein (Putative undecaprenol kinase)( EC:2.7.1.66 )638719417 8.64 9.2 1.33 down 1.08E-‐01 RRSL_04243 o c Hypothetical Protein638719418 10.55 8.64 4.14 up 1.08E-‐01 RRSL_04244 nhaC NhaC638719419 10.73 11.04 1.12 down 5.22E-‐01 RRSL_04245 o c Transcriptional regulator, TetR family638719424 9.4 9.51 1.02 up 8.51E-‐01 RRSL_04250 o c 3-‐deoxy-‐D-‐manno-‐octulosonic-‐acid transferase( EC:2.-‐ )638719425 9.15 10.27 1.98 down 3.30E-‐02 RRSL_04251 o c Lipopolysaccharide heptosyltransferase-‐1( EC:2.-‐ )638719426 11.76 12.73 1.77 down 2.89E-‐02 RRSL_04252 o c Hypothetical Protein638719427 12.47 13.03 1.34 down 1.33E-‐02 RRSL_04253 o c Hypothetical Protein638719428 10.93 11.78 1.64 down 4.92E-‐02 RRSL_04254 o c Putative undecaprenyl-‐phosphate alpha-‐N-‐acetylglucosaminyltransferase( EC:2.4.1.-‐ )638719429 11.71 12.58 1.65 down 1.49E-‐02 RRSL_04255 o c Glycosyltransferase( EC:2.4.1.-‐ )638719430 11.09 11.84 1.52 down 5.82E-‐02 RRSL_04256 o c dTDP-‐rhamnosyl transferase rfbF( EC:2.-‐ )638719431 12.31 12.72 1.21 down 3.43E-‐01 RRSL_04257 o c Oligosaccharide translocase (flippase)638719432 12.22 12.71 1.28 down 2.69E-‐01 RRSL_04258 o c dTDP-‐4-‐dehydrorhamnose 3,5-‐epimerase( EC:5.1.3.13 )638719433 12.36 13.12 1.54 down 9.88E-‐02 RRSL_04259 o c Glucose-‐1-‐phosphate thymidylyltransferase( EC:2.7.7.24 )638719434 9.86 11.35 2.54 down 6.61E-‐02 RRSL_04260 Hypothetical Protein638719435 13.29 14.06 1.55 down 1.13E-‐01 RRSL_04261 o c dTDP-‐glucose 4,6-‐dehydratase( EC:4.2.1.46 )638719436 10.71 10.86 1.01 down 9.31E-‐01 RRSL_04262 o c Bis(5'-‐nucleosyl)-‐tetraphosphatase, symmetrical( EC:3.6.1.41 )638719437 11.56 11.98 1.21 down 1.08E-‐01 RRSL_04263 o c 1-‐acyl-‐sn-‐glycerol-‐3-‐phosphate acyltransferase( EC:2.3.1.51 )638719438 10.7 11.53 1.61 down 8.63E-‐02 RRSL_04264 o c Aspartate carbamoyltransferase non-‐catalytic chain( EC:2.1.3.2 )638719439 10.9 11.49 1.37 down 6.46E-‐02 RRSL_04265 o c Aspartate carbamoyltransferase( EC:2.1.3.2 )638719440 12.37 12.63 1.09 down 5.43E-‐01 RRSL_04266 o c pyrR PyrR( EC:2.4.2.9 )638719441 12.86 13.17 1.12 down 5.62E-‐01 RRSL_04267 o c Transcriptional regulator, algH638719442 10.69 11.56 1.66 down 4.22E-‐03 RRSL_04269 o c Ribosomal small subunit pseudouridine synthase A( EC:4.2.1.70 )638719443 8.74 8.69 1.14 up 3.26E-‐01 RRSL_04268 Deoxyribodipyrimidine photolyase( EC:4.1.99.3 )638719444 10.79 11.53 1.51 down 8.07E-‐02 RRSL_04270 o c Transcription regulator composite two component regulatory protein (sensor histidine kinase and response regulator hybrid)638719445 12.9 13.82 1.73 down 1.42E-‐02 RRSL_04271 o c pilJ PilJ638719446 11.63 12.28 1.42 down 2.29E-‐01 RRSL_04272 o c pilI PilI638719447 12.87 13.66 1.57 down 4.86E-‐02 RRSL_04273 o c pilH PilH638719448 13.57 13.95 1.18 down 3.02E-‐01 RRSL_04274 o c pilG PilG638719449 13.54 13.92 1.17 down 9.72E-‐02 RRSL_04275 o c Rubredoxin638719451 7.63 8.1 1.25 down 2.93E-‐02 RRSL_03826 o c Solute: Na+ symporter permease638719452 13.39 14.46 1.9 down 7.34E-‐02 RRSL_RNA034 ( tRNA )638719454 9.71 9.53 1.25 up 4.33E-‐01 RRSL_03829 Hypothetical Protein638719456 9 9.8 1.58 down 3.17E-‐03 RRSL_03831 o c Mechanosensitive ion channel638719460 12.16 12.04 1.2 up 3.25E-‐02 RRSL_03835 o c Hypothetical Protein638719461 9.58 10.33 1.52 down 3.53E-‐02 RRSL_03836 o c composite two-‐component regulatory protein (sensor kinase and response regulator hybrid)638719464 10.76 11.68 1.71 down 3.53E-‐02 RRSL_03839 o c Lipoprotein signal peptidase( EC:3.4.23.36 )

638719465 12.51 12.37 1.22 up 6.10E-‐01 RRSL_03840 o c phosphopantothenate-‐-‐cysteine ligase / phosphopantothenoylcysteine decarboxylase( EC:4.1.1.36,EC:6.3.2.5 )638719466 10.44 10.98 1.31 down 1.47E-‐03 RRSL_03842 o c Luciferase-‐like monooxygenase( EC:1.14.-‐ )638719467 10.52 11.55 1.85 down 2.70E-‐02 RRSL_03843 o c Deoxyuridine 5'-‐triphosphate nucleotidohydrolase( EC:3.6.1.23 )638719468 12.57 12.78 1.05 down 8.32E-‐01 RRSL_03844 o c Hypothetical Protein638719469 13.93 13.69 1.31 up 1.13E-‐01 RRSL_03845 o c ATP-‐dependent Clp protease adaptor protein ClpS638719471 9.82 9.51 1.37 up 5.11E-‐01 RRSL_03847 o Hypothetical Protein638719472 10.15 9.46 1.78 up 1.87E-‐01 RRSL_03849 o Hypothetical Protein638719473 9.84 10.28 1.22 down 3.25E-‐01 RRSL_03850 Hypothetical Protein638719474 8.87 9.22 1.15 down 5.02E-‐01 RRSL_03852 Core protein638719476 10.45 11.13 1.44 down 4.74E-‐02 RRSL_03854 o rdgC RdgC638719477 9 9.41 1.21 down 2.08E-‐01 RRSL_03855 Hypothetical Protein638719479 8 8.01 1.09 up 6.03E-‐01 RRSL_03857 o c Transcriptional regulator, LysR family638719480 8.89 9.22 1.14 down 1.13E-‐01 RRSL_03858 o c tungstate-‐binding protein precursor638719481 9.78 10.44 1.44 down 1.35E-‐01 RRSL_03859 o c Hypothetical transcriptional regulatory protein638719482 6.7 7.45 1.52 down 2.24E-‐02 RRSL_03860 Hypothetical Protein638719483 8.29 8.29 1.1 up 5.10E-‐01 RRSL_03861 o c Oxidoreductase( EC:1.1.1.-‐ )638719484 10.46 10.58 1.01 up 9.32E-‐01 RRSL_03862 o c Globin Family Protein638719485 9.96 10.58 1.4 down 6.46E-‐02 RRSL_03863 o c Hypothetical protein638719486 10.59 9.99 1.68 up 1.77E-‐02 RRSL_03865 o Probable transmembrane theornine efflux protein.638719487 9.85 10.51 1.43 down 2.02E-‐01 RRSL_03866 o c Lysine decarboxylase family638719488 8.35 7.94 1.46 up 1.84E-‐01 RRSL_03868 o c Lipopolysaccharide N-‐acetylglucosaminyltransferase638719490 7.56 7.57 1.09 up 5.44E-‐01 RRSL_03870 o c Lipase( EC:3.1.1.3 )638719491 11.33 11.3 1.13 up 2.47E-‐01 RRSL_03871 o c Hypothetical Protein638719492 11.38 12.11 1.5 down 3.24E-‐02 RRSL_03872 o c Hypothetical Protein638719493 10.37 11.19 1.6 down 3.90E-‐02 RRSL_03873 o c Hypothetical Protein638719494 11.45 12.23 1.56 down 3.51E-‐02 RRSL_03874 o c Specialized sigma subunits of RNA polymerase638719495 12.41 13.05 1.42 down 2.52E-‐01 RRSL_03875 o c Acetolactate synthase large subunit( EC:2.2.1.6 )638719496 12.29 13.06 1.55 down 1.11E-‐01 RRSL_03876 o c Acetolactate synthase small subunit( EC:2.2.1.6 )638719497 13.04 13.68 1.42 down 1.53E-‐01 RRSL_03877 o c Ketol-‐acid reductoisomerase / 2-‐dehydropantoate 2-‐reductase( EC:1.1.1.169,EC:1.1.1.86 )638719501 9.91 10.64 1.51 down 5.11E-‐02 RRSL_03881 o c Hypothetical Protein638719502 9.77 10.5 1.51 down 4.50E-‐02 RRSL_03882 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638719503 15.96 16.18 1.06 down 5.05E-‐01 RRSL_03884 o c SSU ribosomal protein S15P638719504 14.25 14.83 1.35 down 2.43E-‐01 RRSL_03885 o c Polyribonucleotide nucleotidyltransferase( EC:2.7.7.8 )638719505 10.6 11.41 1.59 down 5.74E-‐02 RRSL_03886 o c Hypothetical protein638719506 10.39 10.84 1.24 down 2.63E-‐01 RRSL_03887 o c Hypothetical Protein638719509 14.65 14.37 1.34 up 1.15E-‐01 RRSL_RNA035 ( tRNA )638719510 14.39 14.8 1.21 down 1.43E-‐01 RRSL_03890 o c NADH-‐quinone oxidoreductase chain A( EC:1.6.5.3 )638719511 13.38 14.17 1.58 down 8.79E-‐02 RRSL_03891 o c NADH-‐quinone oxidoreductase chain B( EC:1.6.5.3 )638719513 12.07 13.22 2.02 down 5.92E-‐02 RRSL_03893 o c Hypothetical Protein( EC:1.6.99.3 )638719514 13.67 14.52 1.64 down 1.96E-‐02 RRSL_03894 o c NADH-‐quinone oxidoreductase chain E( EC:1.6.5.3 )638719515 11.99 13.21 2.1 down 5.39E-‐02 RRSL_03895 o c NADH-‐quinone oxidoreductase chain F( EC:1.6.5.3,EC:1.6.99.5 )638719517 14.09 14.75 1.43 down 7.77E-‐02 RRSL_03897 o c NADH-‐quinone oxidoreductase chain H( EC:1.6.5.3 )638719518 12.71 13.47 1.53 down 9.09E-‐02 RRSL_03898 o c NADH-‐quinone oxidoreductase chain I( EC:1.6.5.3,EC:1.6.99.3 )638719519 12.32 13.32 1.81 down 1.39E-‐02 RRSL_03899 o c NADH-‐quinone oxidoreductase chain J( EC:1.6.5.3 )638719520 14.03 14.41 1.19 down 3.04E-‐01 RRSL_03900 o c NADH-‐quinone oxidoreductase chain K( EC:1.6.5.3 )638719522 13.57 14.22 1.42 down 6.03E-‐02 RRSL_03902 o c NADH-‐quinone oxidoreductase chain M( EC:1.6.5.3 )638719524 11.63 12.76 1.98 down 2.39E-‐02 RRSL_03904 o c Hypothetical protein638719525 10.94 11.44 1.28 down 1.37E-‐02 RRSL_03905 o c Phosphohydrolase (MutT/nudix family protein)638719526 8.9 8.77 1.2 up 2.05E-‐01 RRSL_03906 o c Hypothetical Protein638719527 8.74 8.67 1.16 up 4.30E-‐01 RRSL_03907 o c Acyl-‐CoA dehydrogenase( EC:1.3.99.-‐ )638719528 8.44 8.36 1.17 up 2.93E-‐01 RRSL_03908 o c Acyl-‐CoA dehydrogenase, short-‐chain specific( EC:1.3.99.2 )638719529 8.21 7.78 1.49 up 2.28E-‐02 RRSL_03909 o (R)-‐specific enoyl-‐CoA hydratase( EC:4.2.1.-‐ )638719531 11.31 10.98 1.39 up 1.72E-‐02 RRSL_03911 o amide-‐urea binding protein precursor638719532 9.78 8.91 2.01 up 6.70E-‐02 RRSL_03912 o amide-‐urea transport system permease protein638719533 10 8.99 2.23 up 1.36E-‐01 RRSL_03913 o amide-‐urea transport system permease protein638719534 8.41 8.78 1.17 down 1.35E-‐01 RRSL_03914 o amide-‐urea transport atp-‐binding protein638719535 8.9 9.04 1 up 9.89E-‐01 RRSL_03915 o c amide-‐urea transport atp-‐binding protein638719536 8.07 8.84 1.54 down 4.48E-‐02 RRSL_03916 o ureD UreD638719538 10.35 10.41 1.06 up 7.93E-‐01 RRSL_03919 Transcriptional regulators, LysR family638719540 9.85 9.29 1.63 up 1.95E-‐01 RRSL_03921 o Shikimate kinase( EC:2.7.1.71 )638719543 8.71 8.76 1.06 up 8.55E-‐01 RRSL_03924 Transcriptional regulators, LysR family638719544 8.84 8.9 1.06 up 7.38E-‐01 RRSL_03925 Hypothetical Protein638719545 8.46 8.66 1.04 down 8.96E-‐01 RRSL_03926 o CHRB protein638719546 9.39 9.24 1.23 up 1.44E-‐01 RRSL_03927 o Chromate transport protein638719547 7.22 7.79 1.35 down 1.17E-‐01 RRSL_03928 o CHRB protein638719548 9.13 9.16 1.08 up 7.29E-‐01 RRSL_03929 o Histidine-‐rich glycoprotein precursor.638719549 9.99 10.88 1.69 down 6.42E-‐02 RRSL_03930 o Icc protein638719552 9.38 9.63 1.08 down 7.34E-‐01 RRSL_03933 (partial?) integrase638719553 10.67 10.95 1.1 down 6.15E-‐01 RRSL_03934 Hypothetical Protein638719554 10.45 10.54 1.04 up 8.80E-‐01 RRSL_03935 Hypothetical Protein638719557 8.07 7.56 1.57 up 3.25E-‐01 RRSL_03938 RTX family calcium-‐binding cytotoxins and bacteriocins638719558 15.94 16.22 1.1 down 5.54E-‐01 RRSL_03939 hypothetical protein638719559 9.79 10.44 1.42 down 4.33E-‐02 RRSL_03940 hypothetical protein638719560 10.88 11.72 1.63 down 3.12E-‐03 RRSL_03941 hypothetical protein638719561 9.93 9.76 1.25 up 5.02E-‐01 RRSL_03942 o c Putative lactonase638719563 9.85 9.65 1.26 up 2.02E-‐01 RRSL_03944 Transcriptional regulator, MarR family

638719572 12.82 13.56 1.52 down 5.35E-‐02 RRSL_03953 o L-‐phenylalanine oxidase( EC:1.13.12.9 )638719575 11.49 10.97 1.59 up 3.69E-‐02 RRSL_03956 hypothetical protein638719577 11.5 12.05 1.33 down 2.59E-‐02 RRSL_03958 o c hypothetical protein638719578 7.56 7.34 1.28 up 1.83E-‐01 RRSL_03959 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638719579 11.88 11.7 1.25 up 1.66E-‐01 RRSL_03960 o c hypothetical protein638719580 10.16 11.36 2.09 down 7.27E-‐02 RRSL_03961 o c hypothetical protein638719581 11.84 11.41 1.5 up 7.83E-‐02 RRSL_03962 o Transcriptional regulatory protein638719582 8.6 8.45 1.22 up 7.02E-‐01 RRSL_03963 o c Bacitracin transport permease protein bcrC homolog638719583 9.89 10.66 1.55 down 3.57E-‐02 RRSL_03964 o hypothetical protein638719584 10.12 9.6 1.59 up 1.77E-‐01 RRSL_03965 o Protease Do( EC:3.4.21.-‐ )638719586 10.52 10.6 1.04 up 8.52E-‐01 RRSL_03967 o c Short chain dehydrogenase638719587 10.51 9.49 2.25 up 1.33E-‐01 RRSL_03968 o c hypothetical protein638719589 11.32 11.65 1.14 down 6.45E-‐01 RRSL_03971 o c hypothetical protein638719590 10.3 9.66 1.72 up 9.24E-‐02 RRSL_03972 o c Permease638719591 6.4 7.23 1.62 down 2.75E-‐02 RRSL_03973 o c Phosphinothricin N-‐acetyltransferase( EC:2.3.1.-‐ )638719592 10.55 10.18 1.43 up 2.86E-‐01 RRSL_03974 o c hypothetical protein638719593 9.29 8.36 2.1 up 6.01E-‐02 RRSL_03975 o c D-‐lactate dehydrogenase( EC:1.1.1.28 )638719595 8.62 8.41 1.27 up 1.18E-‐01 RRSL_03977 o c Acetoin catabolism regulatory protein638719596 10.4 10.32 1.17 up 3.70E-‐01 RRSL_03978 o c Aldehyde dehydrogenase( EC:1.2.1.3 )638719597 9.89 9.52 1.43 up 4.20E-‐02 RRSL_03979 o c Ethanolamine ammonia-‐lyase heavy chain( EC:4.3.1.7 )638719598 7.45 7.99 1.32 down 9.58E-‐02 RRSL_03980 o Ethanolamine ammonia-‐lyase light chain( EC:4.3.1.7 )638719599 9.61 9.96 1.15 down 2.55E-‐01 RRSL_03981 o c Exodeoxyribonuclease I( EC:3.1.11.1 )638719601 8.13 8.22 1.03 up 9.22E-‐01 RRSL_03983 o 5-‐nitroimidazole antibiotic resistance protein638719602 8.05 8.63 1.35 down 1.72E-‐01 RRSL_03984 o c Transcriptional regulator, GntR family / AMINOTRANSFERASE CLASS-‐I( EC:2.6.1.-‐ )638719603 11.08 10.93 1.22 up 6.46E-‐02 RRSL_03985 hypothetical protein638719604 12.71 11.88 1.97 up 5.95E-‐02 RRSL_03986 o putative transmembrane protein638719605 11.22 10.6 1.7 up 6.25E-‐02 RRSL_03987 o putative transmembrane protein638719607 10.61 10.94 1.14 down 1.59E-‐02 RRSL_03989 putative MFS transporter638719609 11.75 12.69 1.75 down 1.46E-‐02 RRSL_03991 o c gspD GspD638719610 9.76 9.95 1.03 down 8.16E-‐01 RRSL_03992 o c gspN GspN638719611 11.46 11.87 1.2 down 4.34E-‐01 RRSL_03993 o c gspM GspM638719613 11.91 11.85 1.14 up 2.11E-‐01 RRSL_03995 o c gspK GspK638719614 10.44 11.15 1.49 down 4.04E-‐02 RRSL_03996 o c gspJ GspJ638719616 12.88 13.64 1.54 down 2.99E-‐02 RRSL_03998 o c gspH GspH638719617 13.2 13.73 1.31 down 8.60E-‐02 RRSL_03999 o c gspG GspG638719618 10.26 10.59 1.13 down 3.29E-‐01 RRSL_04000 o c gspC GspC638719619 12.63 12.63 1.1 up 7.21E-‐01 RRSL_04001 o c putative calcium-‐binding protein638719621 10.19 10.45 1.09 down 6.11E-‐01 RRSL_04003 o c Transcriptional regulator, AsnC family638719623 9.55 9.14 1.46 up 6.71E-‐02 RRSL_04005 o c hypothetical protein638719625 10.99 10.49 1.56 up 1.68E-‐01 RRSL_04007 o c Acetyltransferase( EC:2.3.1.-‐ )638719626 9.71 9.69 1.11 up 3.81E-‐01 RRSL_04008 o c kefC KefC638719627 9.09 8.7 1.45 up 1.21E-‐01 RRSL_04009 hypothetical protein638719630 9.45 9.17 1.34 up 1.97E-‐01 RRSL_04013 o RHS-‐related protein638719631 10.55 10.07 1.54 up 6.33E-‐02 RRSL_04014 o RHS-‐related protein638719632 8.8 9.3 1.28 down 1.60E-‐01 RRSL_04015 o GspE-‐related protein638719633 11.05 11.23 1.03 down 8.93E-‐01 RRSL_04016 o Transmembrane protein638719634 10.74 11.24 1.29 down 1.66E-‐01 RRSL_04017 o proline-‐rich signal peptide638719635 8.01 8.54 1.31 down 2.72E-‐01 RRSL_04018 o GspG-‐related protein638719636 8.34 8.59 1.08 down 7.75E-‐01 RRSL_04019 o GspG-‐related protein638719637 9.92 10.29 1.17 down 5.75E-‐01 RRSL_04020 o Transmembrane protein638719638 11.85 12.17 1.13 down 6.86E-‐01 RRSL_04021 o GspG-‐related protein638719640 10.35 11.55 2.09 down 3.34E-‐01 RRSL_04023 o hypothetical protein transmembrane protein638719641 8.79 8.71 1.16 up 2.39E-‐01 RRSL_04024 o hypothetical protein638719642 10.74 10.12 1.7 up 1.12E-‐01 RRSL_04025 hypothetical protein638719643 15.05 14.22 1.96 up 2.26E-‐03 RRSL_04026 o hypothetical protein638719644 13.85 13.32 1.6 up 3.19E-‐02 RRSL_04027 o Cysteine desulfurase638719645 14.72 14.06 1.75 up 8.79E-‐03 RRSL_04028 o putative methyltransferase638719646 9.3 10.57 2.19 down 7.08E-‐02 RRSL_04029 VGR-‐related protein638719647 9.78 11.08 2.23 down 5.25E-‐02 RRSL_04030 o hypothetical protein638719648 10.65 11.16 1.29 down 4.59E-‐01 RRSL_04031 o hypothetical protein638719649 9.88 10.11 1.06 down 7.98E-‐01 RRSL_04032 hypothetical protein638719651 10.72 10.85 1.01 up 9.80E-‐01 RRSL_04034 o Acetyl-‐CoA acetyltransferase( EC:2.3.1.9 )638719652 8.67 9.31 1.41 down 3.92E-‐01 RRSL_04035 o c Short chain dehydrogenase638719653 7.75 7.96 1.05 down 8.54E-‐01 RRSL_04037 o c Acyl-‐CoA dehydrogenase, short-‐chain specific( EC:1.3.99.2 )638719654 9.04 9.34 1.11 down 6.30E-‐01 RRSL_04038 o c 2-‐hydroxychromene-‐2-‐carboxylate isomerase( EC:5.3.99.-‐ )638719655 8.51 9.36 1.63 down 6.09E-‐02 RRSL_04040 o c hypothetical protein638719656 9.27 9.64 1.17 down 5.11E-‐01 RRSL_04041 o c Methylcrotonyl-‐CoA carboxylase carboxyl transferase subunit( EC:6.4.1.4 )638719657 8.91 9.59 1.45 down 3.75E-‐02 RRSL_04042 o c Acylamino-‐acid-‐releasing enzyme( EC:3.4.19.1 )638719658 13.16 13.12 1.13 up 3.50E-‐01 RRSL_04044 o c Biotin synthase( EC:2.8.1.6 )638719659 11.95 11.86 1.17 up 3.63E-‐01 RRSL_03441 o c GTP pyrophosphokinase / Guanosine-‐3',5'-‐bis(Diphosphate) 3'-‐pyrophosphohydrolase( EC:2.7.6.5,EC:3.1.7.2 )638719660 12.99 13.77 1.56 down 4.86E-‐02 RRSL_03442 o c DNA-‐directed RNA polymerase omega chain( EC:2.7.7.6 )638719661 10.71 11.65 1.73 down 3.03E-‐02 RRSL_03443 o c Guanylate kinase( EC:2.7.4.8 )638719663 13.14 13.21 1.05 up 5.86E-‐01 RRSL_03444 o c Cell cycle protein kinase CDC5/MSD2( EC:2.7.1.-‐ )638719664 10.38 10.83 1.23 down 2.72E-‐01 RRSL_03446 o c Protein phosphatase 2C( EC:3.1.3.16 )638719666 9.56 10.59 1.85 down 6.34E-‐03 RRSL_03448 o c Xanthosine triphosphate pyrophosphatase( EC:3.6.1.-‐ )638719667 10.38 10.47 1.04 up 8.01E-‐01 RRSL_03449 o c Coproporphyrinogen oxidase, anaerobic( EC:1.-‐ )

638719669 9.41 10.02 1.38 down 5.81E-‐03 RRSL_03450 o Hypothetical Protein638719670 7.74 8.45 1.48 down 1.95E-‐02 RRSL_03451 o c Pyrrolidone-‐carboxylate peptidase( EC:3.4.19.3 )638719671 8.88 9.6 1.49 down 6.91E-‐02 RRSL_03452 o c C4-‐dicarboxylate-‐binding protein638719674 9.41 10.3 1.69 down 6.76E-‐02 RRSL_03455 o c Lactam utilization protein LAMB638719677 8.06 7.59 1.52 up 1.55E-‐01 RRSL_03459 o c Transmembrane drug transport protein, MFS family638719678 9.72 10.18 1.25 down 1.05E-‐01 RRSL_03460 o c Nucleoside transport ATP-‐binding protein638719679 8.73 8.99 1.09 down 3.62E-‐01 RRSL_03461 o c Nucleoside transport system permease protein638719680 9.07 9.65 1.35 down 9.19E-‐02 RRSL_03462 o c Nucleoside transport system permease protein638719681 12.48 13.07 1.36 down 3.03E-‐03 RRSL_03463 o c Nucleoside-‐binding protein638719682 11.79 12.5 1.48 down 9.38E-‐03 RRSL_03464 o hypothetical protein638719683 12.82 13.28 1.25 down 2.30E-‐03 RRSL_03465 o Hypothetical Protein638719684 12.02 12.67 1.42 down 8.80E-‐03 RRSL_03467 o Hypothetical Protein638719685 12.59 13.15 1.33 down 1.15E-‐02 RRSL_03468 o Hypothetical Protein638719686 10.28 10.76 1.27 down 1.65E-‐02 RRSL_03469 o c Hypothetical Protein638719687 11.03 12.07 1.87 down 4.29E-‐02 RRSL_03470 o c Quinone oxidoreductase( EC:1.6.5.5 )638719688 10.55 11.66 1.96 down 2.06E-‐03 RRSL_03471 o c Methylglyoxal synthase( EC:4.2.3.3 )638719689 10.52 11.09 1.35 down 7.96E-‐02 RRSL_03472 Hypothetical Protein638719690 9.75 9.69 1.15 up 7.08E-‐01 RRSL_03473 o Transporter, drug/metabolite exporter family638719691 9.09 9.65 1.34 down 3.03E-‐02 RRSL_03474 o c Uracil phosphoribosyltransferase( EC:2.4.2.9 )638719692 9.35 10.43 1.92 down 3.10E-‐03 RRSL_03475 o c ATPase638719693 11.87 12.32 1.24 down 1.52E-‐01 RRSL_03476 o c Hypothetical cytosolic protein638719694 11.29 11.79 1.29 down 2.73E-‐01 RRSL_03477 o c Phosphoribosylamine-‐-‐glycine ligase( EC:6.3.4.13 )638719695 9.81 10.69 1.67 down 3.80E-‐02 RRSL_03478 o c Coproporphyrinogen III oxidase( EC:1.3.3.3 )638719696 10.78 11.72 1.74 down 9.85E-‐03 RRSL_03479 o c COG 1057, nicotinic acid mononucleotide adenylyltransferase638719697 15.06 15.02 1.13 up 2.36E-‐01 RRSL_03480 o c iojap protein family638719698 10.95 11.49 1.32 down 1.13E-‐02 RRSL_03481 o c Hypothetical cytosolic protein638719699 9.19 9.25 1.06 up 7.47E-‐01 RRSL_03482 o c Septum formation protein Maf638719700 11.64 11.64 1.1 up 1.94E-‐01 RRSL_03483 o c Ribonuclease G( EC:3.1.4.-‐ )638719701 8.61 8.23 1.44 up 4.82E-‐02 RRSL_03484 o c Hypothetical Protein638719702 10.12 9.7 1.47 up 5.77E-‐02 RRSL_03485 o c Hypothetical protein638719703 10.46 10.8 1.14 down 2.61E-‐01 RRSL_03486 o c ABC-‐TYPE MULTIDRUG TRANSPORT SYSTEM. ATPase and permease components.638719704 10.27 10.82 1.33 down 8.61E-‐02 RRSL_03487 o Hypothetical Protein638719705 8.77 9.45 1.45 down 2.89E-‐02 RRSL_03488 o c alpha-‐L-‐glycero-‐D-‐manno-‐heptose beta-‐1,4-‐glucosyltransferase( EC:2.4.1.-‐ )638719706 10.42 10.79 1.17 down 2.88E-‐01 RRSL_03489 o c Hypothetical Protein638719707 10.45 10.7 1.08 down 5.36E-‐01 RRSL_03490 o c Hypothetical Protein638719708 9.71 10.3 1.36 down 5.86E-‐02 RRSL_03491 o c DNA polymerase III alpha subunit( EC:2.7.7.7 )638719709 12.71 13.04 1.14 down 5.69E-‐01 RRSL_03492 o c Rhodanese-‐related sulfurtransferases638719713 10.65 11.22 1.35 down 6.57E-‐03 RRSL_03497 o c tRNA synthetases class I, catalytic domain638719714 10.72 11.95 2.13 down 6.00E-‐02 RRSL_03498 o c ATP-‐dependent RNA helicase638719716 10.51 10.71 1.04 down 7.57E-‐01 RRSL_03500 o c Transcriptional regulator, TetR family638719717 9.92 9.92 1.11 up 7.31E-‐01 RRSL_03501 o c Metal-‐dependent hydrolase( EC:3.-‐ )638719719 12.94 13.59 1.42 down 1.52E-‐01 RRSL_03502 rpoD RpoD638719720 14.29 14.55 1.08 down 3.82E-‐01 RRSL_03503 RNA polymerase sigma factor rpoD638719721 10.4 11.13 1.5 down 7.67E-‐03 RRSL_03504 o c DNA primase( EC:2.7.7.-‐ )638719723 11.17 9.78 2.9 up 1.03E-‐01 RRSL_03506 o c NAD(FAD)-‐utilizing dehydrogenases638719724 8.95 9.83 1.66 down 5.92E-‐03 RRSL_03507 o c O-‐sialoglycoprotein endopeptidase( EC:3.4.24.57 )638719725 12.11 12.88 1.54 down 5.60E-‐03 RRSL_03509 o c Hypothetical cytosolic protein638719726 13.73 14.08 1.15 down 2.65E-‐01 RRSL_03508 Hypothetical Protein638719727 10.84 11.66 1.6 down 3.65E-‐03 RRSL_03510 o c 1-‐deoxy-‐D-‐xylulose 5-‐phosphate synthase( EC:2.2.1.7,EC:4.1.3.37 )638719728 9.68 10.74 1.89 down 2.15E-‐02 RRSL_03511 o c Dimethylallyltransferase / Geranyltranstransferase / Geranylgeranyl pyrophosphate synthetase( EC:2.5.1.1,EC:2.5.1.10,EC:2.5.1.29 )638719730 11.99 12.43 1.23 down 8.63E-‐02 RRSL_03513 o c AlcE638719731 9.37 9.92 1.33 down 1.39E-‐02 RRSL_03514 o c Transporter, drug/metabolite exporter family638719732 10.25 11.12 1.65 down 5.52E-‐03 RRSL_03515 o c Thiosulfate sulfurtransferase( EC:2.8.1.1 )638719733 11.17 10.9 1.33 up 3.77E-‐01 RRSL_03516 o c Histidine-‐rich protein Ke4638719734 11.29 12.13 1.61 down 1.16E-‐02 RRSL_03518 o c NADH dehydrogenase( EC:1.6.99.3 )638719735 9.87 10.96 1.93 down 2.07E-‐02 RRSL_03520 o c DNA polymerase I( EC:2.7.7.7 )638719736 12.88 13.26 1.18 down 3.83E-‐01 RRSL_03519 o c 3-‐isopropylmalate dehydrogenase( EC:1.1.1.85 )638719737 13.68 14.04 1.16 down 1.45E-‐01 RRSL_03521 o c Hypothetical Protein638719738 10.42 11.37 1.75 down 3.43E-‐03 RRSL_03522 o c Homoserine kinase( EC:2.7.1.39 )638719739 12.14 12.38 1.07 down 4.85E-‐01 RRSL_03523 o c Hypothetical Protein638719740 11.14 12.03 1.68 down 7.93E-‐02 RRSL_03524 o c Valyl-‐tRNA synthetase( EC:6.1.1.9 )638719741 10.32 11.09 1.55 down 1.08E-‐01 RRSL_03526 o c UTP-‐-‐glucose-‐1-‐phosphate uridylyltransferase( EC:2.7.7.9 )638719743 13.33 13.53 1.04 down 8.54E-‐01 RRSL_03528 o c Bacterial Protein Translation Initiation Factor 1 (IF-‐1)638719744 11.06 11.76 1.47 down 1.80E-‐01 RRSL_03529 Hypothetical Protein638719745 13.13 12.38 1.85 up 1.37E-‐02 RRSL_03530 o c Hypothetical Protein638719747 11.9 12.79 1.68 down 3.40E-‐02 RRSL_03532 o c Hypothetical Protein638719748 9.11 9.51 1.2 down 5.34E-‐01 RRSL_03533 o c 4-‐hydroxybenzoate 3-‐monooxygenase( EC:1.14.13.2 )638719749 9.01 7.67 2.78 up 1.91E-‐01 RRSL_03534 o c Transcriptional regulators, LysR family638719751 8.72 9.48 1.53 down 1.99E-‐02 RRSL_03536 o livF LivF638719752 8.52 8.94 1.21 down 4.89E-‐01 RRSL_03537 o livG LivG638719753 10.03 9.57 1.51 up 3.87E-‐01 RRSL_03538 o livM LivM638719754 9.43 9.63 1.04 down 9.04E-‐01 RRSL_03539 o livH LivH638719755 7.99 8.52 1.31 down 1.94E-‐01 RRSL_03540 o c 4-‐carboxymuconolactone decarboxylase( EC:4.1.1.44 )638719756 8.79 9.22 1.22 down 1.38E-‐01 RRSL_03541 o c 3-‐oxoadipate enol-‐lactonase( EC:3.1.1.24 )638719757 7.1 7.92 1.6 down 1.68E-‐01 RRSL_03542 o c 3-‐carboxy-‐cis,cis-‐muconate cycloisomerase( EC:5.5.1.2 )638719758 8.22 9.35 1.97 down 4.63E-‐03 RRSL_03543 o c 3-‐ketoacyl-‐CoA thiolase( EC:2.3.1.16,EC:2.3.1.9 )

638719760 9.38 10.45 1.91 down 8.86E-‐03 RRSL_03545 o c 3-‐oxoadipate CoA-‐transferase subunit B( EC:2.8.3.6 )638719761 8.59 9.46 1.65 down 3.90E-‐02 RRSL_03546 o c 3-‐oxoadipate CoA-‐transferase subunit A( EC:2.8.3.6 )638719762 10.23 9.87 1.42 up 3.75E-‐01 RRSL_03547 o c Transcriptional regulator, IclR family638719763 10.98 11.46 1.27 down 3.99E-‐02 RRSL_03548 o c Hypothetical Protein638719764 10.23 10.66 1.22 down 3.20E-‐01 RRSL_03550 o Hypothetical Protein638719765 9.94 9.53 1.46 up 2.42E-‐01 RRSL_03551 o glnP GlnP638719766 8.93 8.62 1.37 up 4.16E-‐01 RRSL_03552 o Glutamine transport system permease protein glnP638719767 8.35 8.27 1.17 up 4.61E-‐01 RRSL_03553 o c glnQ GlnQ638719769 13.59 14.05 1.24 down 2.49E-‐01 RRSL_03728 o c 4-‐diphosphocytidyl-‐2-‐C-‐methyl-‐D-‐erythritol kinase( EC:2.7.1.148 )638719770 10.32 11.31 1.8 down 7.49E-‐02 RRSL_03729 o c lolB LolB638719771 11.71 12.51 1.58 down 3.88E-‐02 RRSL_03730 o c Tetratricopeptide repeat family protein638719772 9.32 9.83 1.29 down 1.04E-‐01 RRSL_03731 o c Formamidopyrimidine-‐DNA glycosylase( EC:3.2.2.23 )638719773 10.42 10.51 1.04 up 8.65E-‐01 RRSL_03732 o c hypothetical protein638719774 8.86 9.24 1.18 down 1.23E-‐01 RRSL_03733 o c A/G-‐specific adenine DNA glycosylase( EC:3.2.2.-‐ )638719775 11.01 11.62 1.39 down 5.16E-‐02 RRSL_03734 o c ATP-‐dependent protease La( EC:3.4.21.53 )638719776 12.04 12.51 1.26 down 5.41E-‐02 RRSL_03735 o c ATP-‐binding protein (contains P-‐loop)638719777 14.97 15.63 1.43 down 8.97E-‐02 RRSL_03736 o c hypothetical protein638719778 10.15 10.53 1.18 down 3.90E-‐01 RRSL_03737 o c hpr(ser) kinase / phosphatase( EC:2.7.1.-‐,EC:3.1.3.-‐ )638719779 13.04 13.18 1 up 9.80E-‐01 RRSL_03738 o c Nitrogen regulatory IIA protein( EC:2.7.1.69 )638719780 16.78 16.21 1.63 up 2.05E-‐04 RRSL_03739 o c Ribosome-‐associated factor Y638719781 12.33 11.85 1.53 up 2.05E-‐02 RRSL_03740 o c rpoN RpoN638719782 10.89 11.44 1.33 down 1.62E-‐02 RRSL_03741 o c ABC transporter ATP-‐binding protein638719783 11.88 12.62 1.51 down 1.19E-‐02 RRSL_03742 o c Protein yhbN precursor638719784 11.42 11.45 1.08 up 2.97E-‐01 RRSL_03743 o c hypothetical protein638719785 11.61 12.32 1.48 down 6.16E-‐03 RRSL_03744 o c 3-‐deoxy-‐manno-‐octulosonate-‐8-‐phosphatase( EC:3.1.3.45 )638719786 9.88 9.63 1.31 up 7.35E-‐02 RRSL_03745 o c transmembrane glutathione-‐regulated potassium-‐efflux system protein K+/H+ antiporter638719787 10.88 10.35 1.59 up 9.85E-‐03 RRSL_03747 o c protease I( EC:3.4.-‐ )638719788 11.34 11.75 1.2 down 1.13E-‐02 RRSL_03748 o c Adenine phosphoribosyltransferase( EC:2.4.2.7 )638719789 11.03 11.48 1.23 down 9.90E-‐02 RRSL_03750 o c hypothetical protein638719790 10.14 11.07 1.73 down 2.72E-‐04 RRSL_03752 o c Excinuclease ABC subunit A (DNA repair ATP-‐binding protein)638719791 10.02 10.48 1.24 down 2.90E-‐02 RRSL_03752_1 o c transmembrane multidrug-‐efflux transporter MFS-‐family638719792 12.76 13.46 1.47 down 1.05E-‐01 RRSL_03753 o c Single-‐strand DNA binding protein638719793 11.53 11.03 1.57 up 8.50E-‐02 RRSL_03754 o Transcriptional regulator, AraC family638719794 10.17 9.96 1.28 up 1.48E-‐01 RRSL_03755 o low-‐specificity threonine aldolase( EC:4.1.2.5 )638719795 8.95 9.12 1.02 down 8.71E-‐01 RRSL_03756 hypothetical protein638719796 9.01 9.71 1.47 down 2.83E-‐02 RRSL_03758 o c hypothetical protein638719797 9.95 10.8 1.63 down 5.76E-‐03 RRSL_03759 o c 3-‐oxoacyl-‐[acyl-‐carrier-‐protein] synthase( EC:2.3.1.41 )638719798 8.35 8.97 1.39 down 1.95E-‐02 RRSL_03760 o c hypothetical protein638719799 9.44 9.38 1.15 up 3.68E-‐01 RRSL_03761 o c Transporter638719800 9.66 9.13 1.59 up 2.02E-‐01 RRSL_03762 o c hypothetical protein638719801 7.93 7.75 1.25 up 3.98E-‐01 RRSL_03763 o c Dolichol-‐phosphate mannosyltransferase( EC:2.4.1.83 )638719802 9.45 9.1 1.41 up 7.48E-‐02 RRSL_03764 o AMP-‐(fatty)acid ligases638719803 9.28 9.67 1.19 down 2.32E-‐01 RRSL_03765 o c hypothetical protein638719804 14.17 13.2 2.16 up 1.03E-‐01 RRSL_03766 hypothetical protein638719805 11.44 11.82 1.18 down 2.93E-‐01 RRSL_03767 o c Acyl carrier protein638719806 11.59 12.17 1.35 down 3.08E-‐02 RRSL_03768 o c 3-‐oxoacyl-‐[acyl-‐carrier protein] reductase( EC:1.1.1.100 )638719807 12 12.73 1.51 down 2.23E-‐02 RRSL_03770 o c gene II and X proteins638719809 10.67 10.69 1.08 up 7.62E-‐01 RRSL_03772 o c Esterase( EC:3.1.1.-‐ )638719810 11.05 10.84 1.28 up 4.13E-‐01 RRSL_03773 o c hypothetical protein638719811 11.62 11.75 1.01 up 8.70E-‐01 RRSL_03774 o c Gluconokinase( EC:2.7.1.12 )638719812 10.23 9.9 1.39 up 7.86E-‐02 RRSL_03775 o c Long-‐chain-‐fatty-‐acid-‐-‐CoA ligase( EC:6.2.1.3 )638719813 11.58 12.62 1.87 down 3.27E-‐02 RRSL_03776 o c hypothetical protein638719815 8.19 8.05 1.22 up 6.11E-‐01 RRSL_03778 o c Bacteriocin processing peptidase638719816 9.48 8.74 1.84 up 2.44E-‐01 RRSL_03779 o c hypothetical protein638719817 9.65 9.51 1.22 up 2.81E-‐01 RRSL_03780 o c Acetate kinase( EC:2.7.2.1 )638719818 11.11 11.54 1.23 down 4.47E-‐01 RRSL_03781 o c Queuosine biosynthesis protein QueF638719820 7.86 8.11 1.08 down 5.80E-‐01 RRSL_03783 o hypothetical protein638719821 10.62 10.55 1.16 up 5.55E-‐01 RRSL_03785 o c Spore maturation protein A / Spore maturation protein B638719822 10.48 10.74 1.08 down 7.15E-‐01 RRSL_03786 o c hypothetical protein638719823 10.01 11.02 1.83 down 2.63E-‐02 RRSL_03787 o c Anaerobic glycerol-‐3-‐phosphate dehydrogenase subunit C638719824 13.25 14.16 1.7 down 5.98E-‐02 RRSL_03789 o c ABC transporter ATP-‐binding protein638719826 11.29 12.28 1.8 down 2.95E-‐02 RRSL_03791 o c Ubiquinone/menaquinone biosynthesis methyltransferase ubiE( EC:2.1.1.-‐ )638719828 9.78 10.09 1.13 down 2.91E-‐01 RRSL_03793 o c hypothetical protein638719829 10.62 10.52 1.18 up 2.26E-‐01 RRSL_03794 ubiB UbiB638719830 8.81 8.99 1.03 down 9.04E-‐01 RRSL_03795 hypothetical protein638719831 10.93 11.12 1.03 down 8.75E-‐01 RRSL_03796 o c Sodium/pantothenate symporter638719833 12.08 12.66 1.35 down 1.22E-‐03 RRSL_03798 o c transmembrane protein638719835 12.93 13.68 1.52 down 1.63E-‐02 RRSL_03800 o c dATP pyrophosphohydrolase( EC:3.6.1.-‐ )638719836 11.12 12.24 1.97 down 4.81E-‐03 RRSL_03801 o c dioxygenase( EC:1.13.11.-‐ )638719837 10.52 11 1.26 down 9.81E-‐02 RRSL_03802 o c Cardiolipin synthetase( EC:2.7.8.-‐ )638719838 9.47 9.94 1.26 down 2.50E-‐01 RRSL_03803 o c Acetyl-‐CoA:acetoacetyl-‐CoA transferase alpha subunit( EC:2.8.3.-‐ )638719839 11.95 12.69 1.51 down 1.05E-‐01 RRSL_03804 o c Transcriptional regulator, TetR family638719840 12.72 13.57 1.63 down 5.56E-‐02 RRSL_03805 o c Acyl-‐CoA dehydrogenase( EC:1.3.99.3 )638719842 12.85 13.72 1.66 down 7.02E-‐02 RRSL_03807 o c 3-‐ketoacyl-‐CoA thiolase( EC:2.3.1.16 )638719843 10.72 11.94 2.1 down 6.92E-‐02 RRSL_03808 o c dbi-‐related protein 1638719844 10.08 10.13 1.07 up 7.19E-‐01 RRSL_03809 o c Multidrug resistance ABC transporter ATP-‐binding and permease protein

638719845 10.09 10.8 1.48 down 3.70E-‐02 RRSL_03811 o c hypothetical protein638719851 11.52 11.9 1.18 down 3.19E-‐02 RRSL_03817 o c Glutamine amidotransferases class-‐II638719853 8.47 9.13 1.44 down 1.36E-‐01 RRSL_03819 o c Glycerate dehydrogenase / Hydroxypyruvate reductase( EC:1.1.1.29,EC:1.1.1.81 )638719854 9.69 10.58 1.67 down 3.76E-‐02 RRSL_03820 o c Dihydroorotase( EC:3.5.2.3 )638719855 9.97 10.38 1.2 down 1.93E-‐01 RRSL_03821 o c hypothetical protein638719856 10.62 11.14 1.3 down 1.17E-‐01 RRSL_03823 o c OsmC-‐like protein638719857 10.78 10.95 1.02 down 9.33E-‐01 RRSL_03555 o c Potassium channel protein638719858 9.99 9.63 1.41 up 1.31E-‐01 RRSL_03556 o Hypothetical Protein638719859 8.11 8.23 1.02 up 9.38E-‐01 RRSL_03557 Hypothetical Protein638719860 9.3 9.68 1.18 down 3.69E-‐01 RRSL_03558 o c AMP nucleosidase( EC:3.2.2.4 )638719863 7.5 7.7 1.04 down 7.60E-‐01 RRSL_03561 Hypothetical Protein638719864 7.46 7.51 1.06 up 8.27E-‐01 RRSL_03562 Hypothetical Protein638719865 9.72 8.5 2.57 up 1.18E-‐01 RRSL_03563 Hypothetical Protein638719867 14.52 14.64 1.01 up 9.11E-‐01 RRSL_03565 o c Acyl-‐CoA desaturase( EC:1.14.19.1 )638719868 10.99 11.42 1.22 down 1.87E-‐01 RRSL_03566 o c Quinolinate synthetase A( EC:4.1.99.-‐ )638719869 9.61 10.38 1.55 down 9.30E-‐02 RRSL_03567 o c Nicotinate-‐nucleotide pyrophosphorylase (carboxylating)( EC:2.4.2.19 )638719870 9.59 10.46 1.66 down 4.45E-‐02 RRSL_03568 o c L-‐aspartate oxidase( EC:1.4.3.16 )638719871 16.42 16.86 1.23 down 3.95E-‐03 RRSL_03569 o c LSU ribosomal protein L33P638719872 15.32 15.95 1.4 down 1.55E-‐02 RRSL_03570 o c LSU ribosomal protein L28P638719873 9.74 9.48 1.32 up 1.17E-‐01 RRSL_03571 Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638719874 10.24 11.06 1.6 down 1.41E-‐01 RRSL_03573 o c 4-‐hydroxy-‐3-‐methylbut-‐2-‐enyl diphosphate reductase( EC:1.17.1.2 )638719875 14.26 15.29 1.84 down 2.69E-‐02 RRSL_03574 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638719880 9.45 10.14 1.45 down 5.15E-‐02 RRSL_03579 o c Acetyltransferase( EC:2.3.1.-‐ )638719881 12.01 12.88 1.65 down 8.64E-‐03 RRSL_03580 o c Acetylornithine aminotransferase( EC:2.6.1.11 )638719882 12.35 13.12 1.55 down 3.16E-‐03 RRSL_03582 o c Oxidoreductase638719883 9.58 10.59 1.83 down 3.92E-‐02 RRSL_03581 o c Nucleoside-‐diphosphate-‐sugar epimerases638719889 8.4 8.67 1.1 down 6.14E-‐01 RRSL_03587 o c 2-‐hydroxy-‐3-‐oxopropionate reductase( EC:1.1.1.60 )638719890 8.76 9.19 1.23 down 5.52E-‐02 RRSL_03588 o c ABC transporter periplasmic protein.638719891 12.34 12.28 1.15 up 7.96E-‐02 RRSL_03589 o c Cys regulon transcriptional activator638719893 11.67 10.82 1.99 up 3.33E-‐02 RRSL_03591 o c Sulfite reductase (Ferredoxin)( EC:1.8.7.1 )638719895 13.28 12.89 1.44 up 1.66E-‐02 RRSL_03593 o c Phosphoadenosine phosphosulfate reductase( EC:1.8.4.8 )638719896 11.85 11.84 1.1 up 6.89E-‐01 RRSL_03594 o c Sulfate adenylyltransferase subunit 2( EC:2.7.7.4 )638719897 10.96 11.07 1.02 up 9.22E-‐01 RRSL_03595 o c Sulfate adenylyltransferase subunit 1( EC:2.7.7.4 )638719898 10.98 10.88 1.19 up 4.29E-‐01 RRSL_03596 o Hypothetical Protein638719899 10.08 9.47 1.68 up 2.29E-‐02 RRSL_03597 o c 5-‐carboxymethyl-‐2-‐hydroxymuconate delta-‐isomerase( EC:5.3.3.10 )638719900 9.43 9.77 1.15 down 4.41E-‐01 RRSL_03598 o c Hypothetical Protein638719901 10.5 10.78 1.1 down 2.78E-‐01 RRSL_03599 o c Hypothetical membrane spanning protein638719902 13.09 13.35 1.09 down 5.51E-‐01 RRSL_03600 o c Hypothetical membrane spanning protein638719904 13.35 14.18 1.61 down 9.56E-‐04 RRSL_03602 o c DNA polymerase III, chi subunit( EC:2.7.7.7 )638719905 9.84 10.72 1.67 down 8.30E-‐03 RRSL_03603 o c Hypothetical Protein638719906 10.8 11.76 1.75 down 2.93E-‐03 RRSL_03604 o c Dihydroxy-‐acid dehydratase( EC:4.2.1.9 )638719907 8.61 8.74 1.01 up 9.66E-‐01 RRSL_03605 o c Transcriptional regulators, LysR family638719908 11.67 12.3 1.41 down 3.53E-‐02 RRSL_03606 o c Prolipoprotein diacylglyceryl transferase( EC:2.4.99.-‐ )638719910 11.83 11.86 1.09 up 5.75E-‐01 RRSL_03608 o c Hypothetical protein638719911 13.38 14.08 1.48 down 1.05E-‐02 RRSL_03609 o c Hypothetical Protein638719912 10.57 10.83 1.09 down 6.87E-‐01 RRSL_03610 o c Vitamin B12 receptor638719913 9.7 9.48 1.29 up 1.83E-‐01 RRSL_03611 o c fecD FecD638719914 9.58 9.28 1.35 up 4.35E-‐01 RRSL_03612 o c Hypothetical Protein638719915 12.4 12.27 1.21 up 5.07E-‐01 RRSL_03613 o c Nicotinate-‐nucleotide-‐-‐dimethylbenzimidazole phosphoribosyltransferase( EC:2.4.2.21 )638719916 9.48 9.75 1.09 down 4.10E-‐01 RRSL_03614 o c Cobalamin [5'-‐phosphate] synthase( EC:2.-‐ )638719917 9.65 9.55 1.18 up 3.19E-‐01 RRSL_03615 o c Alpha-‐ribazole-‐5'-‐phosphate phosphatase( EC:3.1.3.-‐ )638719918 7.9 8.48 1.35 down 2.08E-‐01 RRSL_03617 o c CobC protein638719919 8.94 9.12 1.03 down 7.88E-‐01 RRSL_03618 o c Hypothetical Protein638719920 10.07 10.65 1.36 down 1.54E-‐02 RRSL_03619 o c cobinamide kinase / cobinamide phosphate guanylyltransferase( EC:2.7.1.-‐,EC:2.7.7.-‐ )638719921 10.06 10.51 1.24 down 1.09E-‐01 RRSL_03620 o c Cobyric acid synthase( EC:3.-‐ )638719922 9.3 9.37 1.05 up 5.84E-‐01 RRSL_03621 o c Hypothetical Protein638719923 11.67 12.19 1.3 down 2.14E-‐02 RRSL_03622 o c Pantoate-‐-‐beta-‐alanine ligase( EC:6.3.2.1 )638719924 12.06 12.99 1.72 down 2.61E-‐02 RRSL_03623 o c Segregation and condensation protein ScpA638719925 8.67 8.92 1.08 down 4.41E-‐01 RRSL_03624 o c Outer membrane protein638719926 10.36 10.13 1.29 up 1.78E-‐01 RRSL_03625 o c Hypothetical Outer Membrane Protein638719927 13.25 13.01 1.3 up 3.40E-‐03 RRSL_03626 o c Hypothetical Protein638719928 11.36 12.2 1.62 down 7.78E-‐02 RRSL_03627 o c Methionyl-‐tRNA synthetase / Protein secretion chaperonin CsaA( EC:6.1.1.10 )638719929 15.56 16.23 1.45 down 4.14E-‐03 RRSL_03628 o Hypothetical Protein638719930 12.66 12.18 1.54 up 3.06E-‐01 RRSL_03629 o c Iron-‐sulfur cluster assembly/repair protein ApbC638719931 9.27 8.68 1.66 up 1.47E-‐01 RRSL_03631 o c Hypothetical Protein638719933 7.02 7.35 1.14 down 1.63E-‐01 RRSL_03633 o Hypothetical Protein638719942 11.49 12.15 1.44 down 1.08E-‐03 RRSL_03642 o c Deoxycytidine triphosphate deaminase( EC:3.5.4.13 )638719943 10.68 11.59 1.71 down 5.23E-‐02 RRSL_03643 o c Biodegradative arginine decarboxylase( EC:4.1.1.19 )638719945 10.32 9.75 1.65 up 1.01E-‐02 RRSL_03647 o c RNA polymerase sigma factor sigk638719947 11.66 10.94 1.81 up 1.95E-‐01 RRSL_03649 Transcriptional regulators, LysR family638719948 8.72 8.31 1.47 up 2.03E-‐01 RRSL_03648 Hypothetical Protein638719949 15.72 16.01 1.11 down 4.33E-‐01 RRSL_00715 Protein translocase subunit YajC638719951 12.37 13.51 2 down 1.07E-‐02 RRSL_00717 o c Protein translocase subunit secF638719955 12.74 13.79 1.88 down 6.61E-‐03 RRSL_00722 o c Adenylosuccinate lyase( EC:4.3.2.2 )638719956 9.71 10.57 1.64 down 1.40E-‐03 RRSL_00723 o c Ferredoxin-‐dependent glutamate synthase( EC:1.4.7.1 )638719957 10.06 10.79 1.51 down 3.02E-‐03 RRSL_00724 o c tRNA (5-‐methylaminomethyl-‐2-‐thiouridylate)-‐methyltransferase( EC:2.1.1.61 )

638719959 8.6 9.36 1.54 down 2.40E-‐02 RRSL_00726 o c Transcriptional regulator, MarR family638719960 8.77 7.71 2.3 up 1.41E-‐01 RRSL_00727 o c Transmembrane multidrug resistance transport protein. HLYD family638719961 10.91 9.66 2.62 up 5.17E-‐02 RRSL_00727_1 o c Multidrug resistance protein, MFS family638719962 10.16 10.13 1.13 up 8.03E-‐01 RRSL_00728 o c Hypothetical protein638719964 10.68 11.25 1.34 down 2.11E-‐01 RRSL_00730 o c NAD(P) transhydrogenase alpha subunit( EC:1.6.1.2 )638719965 12.57 12.95 1.18 down 4.73E-‐01 RRSL_00731 o c Aspartate 1-‐decarboxylase( EC:4.1.1.11 )638719966 11.83 12.39 1.34 down 2.21E-‐01 RRSL_00732 o c NAD(P) transhydrogenase alpha subunit( EC:1.6.1.2 )638719967 10.9 11.25 1.16 down 4.85E-‐01 RRSL_00733 o c pntB PntB( EC:1.6.1.1 )638719968 12.34 12.99 1.43 down 7.60E-‐02 RRSL_00734 o c Two-‐component response regulator638719969 13.11 13.51 1.19 down 1.71E-‐01 RRSL_00736 o c phcB PhcB638719970 11.01 11.54 1.31 down 1.48E-‐02 RRSL_00737 o c phcS PhcS638719971 10.26 11.18 1.71 down 1.02E-‐01 RRSL_00738 o c phcR PhcR638719972 11.29 12.39 1.94 down 9.17E-‐03 RRSL_02708 o c Methyltransferase( EC:2.1.1.-‐ )638719973 11.21 11.81 1.37 down 2.67E-‐02 RRSL_02707 o c Hypothetical membrane spanning protein638719976 9.79 10.83 1.85 down 2.24E-‐02 RRSL_02704 o c Rare lipoprotein B precursor (rlpB)638719977 10.95 12.06 1.95 down 6.54E-‐02 RRSL_02703 o c Leucyl-‐tRNA synthetase( EC:6.1.1.4 )638719979 12.33 13.12 1.57 down 1.86E-‐02 RRSL_02701 o c Hypothetical Protein638719980 12.76 13.38 1.39 down 8.52E-‐02 RRSL_02700 o c fur Fur638719981 13.3 13.33 1.08 up 7.38E-‐01 RRSL_02699 o c phcA PhcA638719982 9.17 9.6 1.22 down 1.03E-‐01 RRSL_02698 Hypothetical Protein638719985 9.92 10.84 1.72 down 4.19E-‐02 RRSL_02695 o c PhnB protein638719986 11.17 11.5 1.14 down 3.07E-‐01 RRSL_02694 o c surface protein638719987 9.26 10.31 1.88 down 9.30E-‐02 RRSL_02693 o c Hypothetical Protein638719988 12.57 13.38 1.58 down 2.54E-‐02 RRSL_02692 o c Hypothetical Protein638719989 13.57 14.26 1.46 down 1.67E-‐02 RRSL_02691 o c Guanyl-‐specific ribonuclease( EC:3.1.27.3 )638719991 10.08 10.69 1.38 down 1.78E-‐01 RRSL_02688 o c Thiamine-‐monophosphate kinase( EC:2.7.4.16 )638719992 8.04 8.87 1.61 down 5.05E-‐02 RRSL_02686 o Putative competence-‐damage protein638719993 10.55 11.1 1.33 down 9.27E-‐03 RRSL_02685 o c czcD CzcD638719994 11.41 12.49 1.92 down 6.14E-‐03 RRSL_02684 o c Orotidine 5'-‐phosphate decarboxylase( EC:4.1.1.23 )638719995 10.51 10.46 1.14 up 3.42E-‐01 RRSL_02683 o c corA CorA638719997 9.87 9.99 1.02 up 8.92E-‐01 RRSL_02681 o c Monofunctional biosynthetic peptidoglycan transglycosylase( EC:2.4.2.-‐ )638719999 11.95 12.89 1.74 down 6.35E-‐03 RRSL_02679 o c Transporter638720000 8.84 9.84 1.81 down 2.07E-‐02 RRSL_02678 o c Exoribonuclease II( EC:3.1.13.1 )638720001 8.91 9.32 1.2 down 2.55E-‐01 RRSL_02677 o c Chorismate-‐-‐pyruvate lyase( EC:4.-‐ )638720002 10.1 11.23 1.98 down 6.93E-‐03 RRSL_02676 o c Hypothetical protein638720003 13.19 13.5 1.12 down 4.86E-‐01 RRSL_02674 o c UDP-‐N-‐acetylmuramate:L-‐alanyl-‐gamma-‐D-‐glutamyl-‐ meso-‐diaminopimelate ligase( EC:6.3.2.-‐ )638720004 9.34 10.1 1.53 down 2.09E-‐02 RRSL_02675 o c Hypothetical Protein638720005 10.16 10.99 1.6 down 1.06E-‐02 RRSL_02673 o c Transmembrane thioredoxin-‐related protein638720006 12.38 12.72 1.14 down 1.94E-‐01 RRSL_02672 o c 3-‐dehydroquinate dehydratase( EC:4.2.1.10 )638720010 9.82 10.89 1.9 down 5.55E-‐03 RRSL_02668 o c Hypothetical Protein638720014 15.71 15.63 1.17 up 9.30E-‐02 RRSL_02664 o c Hypothetical Protein638720015 8.38 8.23 1.22 up 2.54E-‐01 RRSL_02661 o c putative hemmaglutinin-‐related transmembrane protein.638720016 8.76 8.37 1.45 up 1.81E-‐01 RRSL_02660 o c Hypothetical Protein638720017 10.64 9.4 2.6 up 6.95E-‐02 RRSL_02659 o c Hypothetical Protein638720018 8.95 8.22 1.83 up 2.31E-‐01 RRSL_02658 o Probable transmembrane methyl-‐accepting chemotaxis protein638720019 10.25 10.94 1.46 down 1.62E-‐01 RRSL_02657 o c hypothetical protein638720020 11.55 10.49 2.3 up 1.73E-‐01 RRSL_02656 o c Transporter, drug/metabolite exporter family638720022 12.95 13.61 1.43 down 5.38E-‐02 RRSL_02653 o c Ribonucleoside-‐diphosphate reductase beta chain( EC:1.17.4.1 )638720023 11.61 12.84 2.12 down 6.57E-‐02 RRSL_02651 o c Ribonucleoside-‐diphosphate reductase alpha chain( EC:1.17.4.1 )638720024 8.32 8.99 1.44 down 2.99E-‐02 RRSL_02650 o c anhydro-‐N-‐acetylmuramyl-‐tripeptide amidase638720025 9.37 10.42 1.87 down 5.70E-‐03 RRSL_02649 o c pehR PehR638720026 8.09 8.32 1.06 down 6.80E-‐01 RRSL_02648 o c Sensor protein pilS( EC:2.7.3.-‐ )638720027 10.18 10.19 1.1 up 6.36E-‐01 RRSL_02646 o c Hypothetical Protein638720028 12.08 12.91 1.62 down 3.08E-‐02 RRSL_02645 o c signal recognition particle, subunit ffh/srp54638720029 11.57 12.07 1.28 down 8.98E-‐02 RRSL_02643 o c Hypoxanthine-‐guanine phosphoribosyltransferase( EC:2.4.2.8 )638720031 9.01 9.73 1.49 down 8.05E-‐03 RRSL_02641 o c Prolyl 4-‐hydroxylase alpha subunit( EC:1.14.11.2 )638720032 10.42 11.46 1.87 down 8.92E-‐03 RRSL_02640 o c Soluble lytic murein transglycosylase( EC:3.2.1.-‐ )638720034 9.66 10.08 1.22 down 1.24E-‐01 RRSL_02638 o c Bis(5'-‐nucleosyl)-‐tetraphosphatase (asymmetrical)( EC:3.6.1.17 )638720035 11.91 11.89 1.12 up 1.77E-‐01 RRSL_02637 o c Lipoprotein638720036 10.44 11.31 1.65 down 2.35E-‐02 RRSL_02636 o c Glutamate 5-‐kinase( EC:2.7.2.11 )638720037 11.41 12.22 1.59 down 5.92E-‐02 RRSL_02635 o c GTP-‐binding protein CgtA (probably involved in DNA repair)638720038 15.19 16.09 1.69 down 8.24E-‐03 RRSL_02634 o c LSU ribosomal protein L27P638720039 16.13 16.59 1.25 down 1.51E-‐02 RRSL_02633 o c LSU ribosomal protein L21P638720040 14.44 15.35 1.69 down 1.32E-‐02 RRSL_03267 o c LSU ribosomal protein L25P638720041 11.13 11.97 1.62 down 1.17E-‐02 RRSL_03268 o c Peptidyl-‐tRNA hydrolase( EC:3.1.1.29 )638720042 8.56 9.26 1.48 down 2.10E-‐02 RRSL_03269 o c Hypothetical Protein638720043 12.15 12.85 1.47 down 5.16E-‐03 RRSL_03270 o c Ferredoxin638720044 11.6 12.3 1.47 down 2.97E-‐02 RRSL_03272 o c Phosphopantetheine adenylyltransferase( EC:2.7.7.3 )638720045 8.39 9.27 1.67 down 2.41E-‐03 RRSL_03273 o c Methyltransferase( EC:2.1.1.-‐ )638720050 10.03 10.73 1.47 down 2.67E-‐02 RRSL_03279 fumarylpyruvate hydrolase( EC:3.7.1.5 )638720051 9.99 9.63 1.42 up 3.78E-‐01 RRSL_03280 o c nitrate transporter, nasF638720052 8.78 8.06 1.82 up 4.35E-‐02 RRSL_03281 o c nrtB NrtB638720053 9.69 9.52 1.24 up 5.95E-‐01 RRSL_03282 o c nrtC NrtC638720054 9.4 10.4 1.81 down 5.63E-‐03 RRSL_03283 o c Anthranilate phosphoribosyltransferase trpD3( EC:2.4.2.18 )638720055 9.63 10.41 1.55 down 6.71E-‐02 RRSL_03284 o c Pirin638720056 12.72 12.01 1.8 up 1.25E-‐01 RRSL_03286 o c Hypothetical Protein

638720057 8.37 7.63 1.85 up 5.35E-‐02 RRSL_03285 o c Sensory box/GGDEF family protein638720059 13.78 14.03 1.08 down 7.65E-‐01 RRSL_03288 o c Hypothetical Protein638720060 10.79 11.31 1.3 down 9.71E-‐02 RRSL_03289 o c Protoheme IX farnesyltransferase638720061 10.1 10.49 1.18 down 1.79E-‐01 RRSL_03290 o c Heme O monooxygenase (ferredoxin)( EC:1.14.15.-‐ )638720062 11.32 11.62 1.12 down 2.88E-‐01 RRSL_03291 o c Hypothetical Protein638720063 10.94 10.77 1.24 up 2.75E-‐01 RRSL_03292 o c Cytochrome c oxidase assembly protein Surf1638720064 11.42 11.61 1.04 down 5.59E-‐01 RRSL_03293 o c Hypothetical Protein638720065 14.03 14.25 1.06 down 5.10E-‐01 RRSL_03294 o c Cytochrome c oxidase polypeptide III( EC:1.9.3.1 )638720066 12.81 13.38 1.35 down 1.03E-‐01 RRSL_03295 o c Hypothetical Protein638720067 13.18 13.66 1.26 down 2.24E-‐01 RRSL_03296 o c ctaG CtaG638720068 14.29 14.66 1.16 down 2.68E-‐01 RRSL_03297 o Hypothetical Protein638720071 13.21 14.02 1.59 down 4.87E-‐02 RRSL_03300 o c Hypothetical Protein638720072 10.21 10.69 1.27 down 8.77E-‐03 RRSL_03302 o c bioC BioC638720073 7.63 7.7 1.05 up 6.66E-‐01 RRSL_03301 o c Amidophosphoribosyltransferase family protein638720074 9.14 10.04 1.69 down 2.67E-‐03 RRSL_03303 o 23S rRNA methyltransferase( EC:2.1.1.-‐ )638720075 8.38 9.32 1.74 down 2.60E-‐03 RRSL_03304 o c Glycerol-‐3-‐phosphate dehydrogenase (NAD(P)+)( EC:1.1.1.94 )638720076 14.83 15.46 1.4 down 5.16E-‐03 RRSL_03305 o c Protein translocase subunit secB638720077 12.24 13.23 1.79 down 5.86E-‐03 RRSL_03306 o c Glutaredoxin638720078 12.4 13.18 1.55 down 3.23E-‐03 RRSL_03307 o c Rhodanese-‐related sulfurtransferases638720079 12.76 13.77 1.82 down 5.95E-‐03 RRSL_03308 o c Phosphoglycerate mutase( EC:5.4.2.1 )638720080 13.04 14.09 1.88 down 2.34E-‐02 RRSL_03309 o c Carboxy-‐terminal processing protease precursor( EC:3.4.21.102 )638720081 8.8 9.79 1.8 down 1.56E-‐03 RRSL_03310 o c Molybdopterin biosynthesis MoeB protein638720082 13.88 14.45 1.34 down 1.53E-‐01 RRSL_03311 o c Bacterioferritin638720083 11.86 11.69 1.24 up 1.59E-‐01 RRSL_03312 o c Hypothetical Protein638720084 10.74 11.97 2.12 down 5.64E-‐02 RRSL_03313 o c Phosphoenolpyruvate-‐protein phosphotransferase( EC:2.7.3.9 )638720085 12.85 13.68 1.61 down 7.58E-‐03 RRSL_03314 o c Phosphocarrier protein HPr638720087 12.58 13.07 1.27 down 8.70E-‐02 RRSL_03316 o c Glutathione synthetase( EC:6.3.2.3 )638720088 11.74 12.78 1.87 down 5.72E-‐02 RRSL_03317 o c Glutamate-‐-‐cysteine ligase( EC:6.3.2.2 )638720089 11.05 11.5 1.23 down 4.95E-‐02 RRSL_03319 o c Ammonium transporter / Methylammonium transporter638720090 11.66 12.56 1.69 down 4.51E-‐02 RRSL_03320 o c Nitrogen regulatory protein GlnK638720091 10.9 11.97 1.91 down 5.90E-‐02 RRSL_03321 o Hypothetical Protein638720092 13.19 13.43 1.07 down 5.67E-‐01 RRSL_03322 o c Hypothetical protein638720093 11.32 10.78 1.61 up 6.10E-‐02 RRSL_03323 o c Hypothetical Protein638720094 8.83 8.41 1.47 up 1.39E-‐01 RRSL_03324 o c ATPase related to magnesium chelatase subunit ChlI638720095 15.11 15.32 1.05 down 4.10E-‐01 RRSL_03325 o c Polyphenol oxidase A1 precursor( EC:1.10.3.1 )638720096 12.59 13.26 1.44 down 8.23E-‐02 RRSL_03326 o c Hypothetical Protein638720097 8.78 9.41 1.41 down 5.05E-‐02 RRSL_03327 o c Hypothetical Protein638720098 11.49 11.74 1.07 down 5.41E-‐01 RRSL_03328 o c ATPase associated with chromosome architecture/replication638720099 11.08 11.69 1.38 down 5.10E-‐02 RRSL_03329 o c Hypothetical Protein638720100 7.7 7.91 1.05 down 8.26E-‐01 RRSL_03330 o Transposase638720101 8.48 8.92 1.23 down 3.46E-‐01 RRSL_03331 o c dctD DctD638720102 7.99 8.19 1.04 down 7.24E-‐01 RRSL_03332 o c C4-‐dicarboxylate transport sensor protein dctB( EC:2.7.3.-‐ )638720103 10.88 11.21 1.14 down 3.45E-‐01 RRSL_03333 o c C4-‐dicarboxylate transport protein638720104 12.11 12.95 1.62 down 4.19E-‐02 RRSL_03334 o c Ferredoxin 2Fe-‐2S638720105 12.68 13.65 1.78 down 2.87E-‐03 RRSL_03335 o c D-‐alanyl-‐D-‐alanine carboxypeptidase( EC:3.4.16.4 )638720106 10.59 11.65 1.88 down 1.23E-‐02 RRSL_03336 o c Hypothetical transcriptional regulatory protein638720107 8.28 8.5 1.06 down 6.60E-‐01 RRSL_03337 o c Transcriptional regulators, LysR family638720108 13.48 12.94 1.61 up 1.12E-‐01 RRSL_03338 o c Hypothetical Protein638720109 10.87 11.85 1.78 down 7.06E-‐02 RRSL_03339 o c Lipoate-‐protein ligase B( EC:6.-‐ )638720110 11.88 12.4 1.3 down 3.06E-‐01 RRSL_03340 o c Lipoic acid synthetase( EC:2.8.-‐ )638720111 12.44 12.08 1.42 up 6.61E-‐03 RRSL_03341 Hypothetical Protein638720113 10.19 9.98 1.27 up 4.33E-‐01 RRSL_03343 Hypothetical Protein638720114 9.5 8.72 1.89 up 9.66E-‐02 RRSL_03344 Hypothetical Protein638720115 9.46 8.51 2.13 up 7.03E-‐02 RRSL_03345 Hypothetical Protein638720116 7.18 6.84 1.4 up 1.60E-‐01 RRSL_03346 Hypothetical Protein638720117 10.28 10.29 1.09 up 5.32E-‐01 RRSL_03347 Hypothetical Protein638720118 8.12 8.04 1.17 up 5.57E-‐01 RRSL_03348 Hypothetical Protein638720119 8.37 7.53 1.98 up 1.36E-‐01 RRSL_03349 Hypothetical Protein638720120 9.11 9.33 1.06 down 7.92E-‐01 RRSL_03350 Hypothetical Protein638720121 9.6 9.87 1.09 down 6.31E-‐01 RRSL_03351 Hypothetical Protein638720122 10.93 10.94 1.1 up 3.51E-‐01 RRSL_03352 Rep protein638720123 12.86 12.2 1.74 up 2.52E-‐03 RRSL_03353 Hypothetical Protein638720126 8.54 9.28 1.51 down 1.27E-‐01 RRSL_03355 o c ATPase, AAA family638720127 14.65 14.99 1.15 down 1.33E-‐01 RRSL_03357 Hypothetical Protein638720128 12.39 12.91 1.3 down 1.09E-‐02 RRSL_03359 DNA modification methyltransferase-‐related protein638720129 10.68 11.65 1.77 down 1.68E-‐02 RRSL_03360 Hypothetical cytosolic protein638720130 12.05 12.25 1.04 down 7.35E-‐01 RRSL_03361 Hypothetical cytosolic protein638720131 10.71 10.62 1.17 up 4.95E-‐01 RRSL_03362 Hypothetical Protein638720135 10.05 11.03 1.79 down 5.37E-‐03 RRSL_03655 Hypothetical Protein638720136 10.94 11.38 1.23 down 3.58E-‐01 RRSL_03656 Hypothetical protein638720137 12.38 12.21 1.24 up 2.22E-‐01 RRSL_03657 Hypothetical Protein638720138 9.09 9.37 1.1 down 5.27E-‐01 RRSL_03658 o oligopeptide transporter638720139 11.24 11.99 1.52 down 2.28E-‐02 RRSL_03659 o c Hypothetical protein638720140 10.94 11.29 1.15 down 2.80E-‐02 RRSL_03660 o c Hypothetical Protein638720143 8.51 8.75 1.07 down 6.69E-‐01 RRSL_03663 o c Primosomal protein N638720145 9.78 9.55 1.29 up 1.04E-‐01 RRSL_03666 o c Hypothetical Protein

638720146 11.49 11.39 1.18 up 1.01E-‐01 RRSL_03667 o c Hypothetical protein638720147 9.89 9.24 1.73 up 3.91E-‐02 RRSL_03668 o c Hypothetical Protein638720149 11.66 11.52 1.22 up 2.46E-‐01 RRSL_03670 Hypothetical Protein638720150 8.13 8.03 1.18 up 3.65E-‐01 RRSL_03671 o Transcriptional regulators, LysR family638720151 11.16 10.41 1.86 up 2.25E-‐02 RRSL_03672 o Glutathione S-‐transferase( EC:2.5.1.18 )638720152 9.31 9.02 1.35 up 4.45E-‐01 RRSL_03673 o c Phosphate-‐binding protein638720153 10.24 9.69 1.62 up 8.39E-‐02 RRSL_03674 o c Hypothetical Protein638720154 8.44 9.35 1.7 down 2.73E-‐02 RRSL_03675 o c Hypothetical Protein638720155 10.02 10.9 1.67 down 2.63E-‐02 RRSL_03676 o c CoA binding protein638720156 10.3 11.01 1.48 down 8.29E-‐03 RRSL_03677 o c Hypothetical Protein638720157 7.94 8.77 1.61 down 3.19E-‐02 RRSL_03678 o c Hypothetical Protein638720160 13.33 14.44 1.96 down 6.16E-‐02 RRSL_03681 o c ATP synthase gamma chain( EC:3.6.3.14 )638720162 14.97 15.46 1.27 down 1.06E-‐01 RRSL_03683 o c ATP synthase delta chain( EC:3.6.3.14 )638720163 14.78 15.42 1.41 down 1.18E-‐01 RRSL_03684 o c ATP synthase B chain( EC:3.6.3.14 )638720164 15.92 16.42 1.28 down 2.78E-‐02 RRSL_03685 o ATP synthase C chain( EC:3.6.3.14 )638720166 12.37 13.48 1.96 down 1.93E-‐02 RRSL_03687 o c Hypothetical Protein638720167 10.01 10.79 1.56 down 2.42E-‐02 RRSL_03688 o c parB ParB638720168 10.73 11.57 1.62 down 8.93E-‐03 RRSL_03689 o c parA ParA638720169 9.58 10.71 1.98 down 2.45E-‐03 RRSL_03690 o c Methyltransferase gidB( EC:2.1.-‐ )638720170 11.01 12.07 1.89 down 4.13E-‐03 RRSL_03691 o c Putative tRNA (5-‐carboxymethylaminomethyl-‐2-‐thiouridylate) synthase subunit GidA638720172 9.81 7.75 4.62 up 9.37E-‐02 RRSL_03693 o short chain dehydrogenase638720173 9.88 10.09 1.05 down 7.92E-‐01 RRSL_03694 o Transcriptional regulators, LysR family638720174 9.62 9.36 1.32 up 1.58E-‐01 RRSL_03695 o c Hypothetical protein638720175 8.16 8.33 1.02 down 8.99E-‐01 RRSL_03697 o c Transcriptional regulators, LysR family638720176 9.92 8.62 2.73 up 8.60E-‐02 RRSL_03696 o NADPH-‐dependent glutamate synthase beta chain and related oxidoreductases638720177 9.33 9.6 1.09 down 7.54E-‐01 RRSL_03698 Hypothetical Protein638720179 12.12 11.7 1.48 up 7.57E-‐02 RRSL_03700 Hypothetical Protein638720180 13.36 13.08 1.34 up 2.85E-‐03 RRSL_03702 Hypothetical Protein638720182 8.81 8.03 1.89 up 1.68E-‐02 RRSL_03704 o Sensor protein luxN( EC:2.7.3.-‐ )638720184 7.6 7.59 1.11 up 5.23E-‐01 RRSL_03706 o Transcriptional regulators, LysR family638720187 9.95 9.31 1.72 up 9.15E-‐02 RRSL_03709 o Transcriptional regulator, MarR family638720189 9.12 8.14 2.18 up 6.92E-‐02 RRSL_03711 o Salicylaldehyde dehydrogenase( EC:1.2.1.65 )638720191 8.09 7.56 1.59 up 3.94E-‐02 RRSL_03713 Feruloyl-‐CoA synthetase638720193 8.26 8.14 1.2 up 3.37E-‐01 RRSL_03715 o Benzaldehyde dehydrogenase (NAD+)( EC:1.2.1.28 )638720194 7.77 7.27 1.57 up 1.12E-‐01 RRSL_03716 o Hypothetical Protein638720195 8.78 7.13 3.46 up 6.01E-‐02 RRSL_03718 o Hypothetical Protein638720196 9.49 8.54 2.13 up 1.05E-‐01 RRSL_03719 o Lipase( EC:3.1.1.3 )638720197 9.46 8.76 1.79 up 1.33E-‐02 RRSL_03720 SAM-‐dependent methyltransferase638720198 9.17 9.25 1.04 up 4.93E-‐01 RRSL_03721 o Putative lactonase638720199 9.91 8.88 2.25 up 1.19E-‐01 RRSL_03722 o c Transporter, MFS superfamily638720200 7.62 8.31 1.47 down 1.11E-‐01 RRSL_03723 o maltooligosyltrehalose synthase( EC:5.4.99.16 )638720201 7.05 7.98 1.72 down 7.64E-‐03 RRSL_03724 Hypothetical Protein638720202 7.81 7.59 1.29 up 3.86E-‐02 RRSL_03725 o maltooligosyltrehalose trehalohydrolase( EC:3.2.1.141 )638720203 9.1 9.5 1.2 down 1.93E-‐01 RRSL_03726 o glgX GlgX638720205 9.42 8.99 1.48 up 9.66E-‐02 RRSL_03365 o c Transcriptional regulator, GntR family / TYROSINE AMINOTRANSFERASE( EC:2.6.1.5 )638720206 11.61 11.31 1.36 up 4.27E-‐02 RRSL_03367 o c Acetoacetate decarboxylase( EC:4.1.1.4 )638720207 10.56 10.7 1.00E+00 RRSL_03368 o c D-‐beta-‐hydroxybutyrate dehydrogenase( EC:1.1.1.30 )638720208 11.51 11.42 1.17 up 3.63E-‐01 RRSL_03369 o c Serine protease( EC:3.4.21.-‐ )638720218 8.1 8.19 1.04 up 8.77E-‐01 RRSL_03381 o Hypothetical Protein638720219 12.66 12.33 1.39 up 6.49E-‐03 RRSL_03383 o Transcriptional regulator, MerR family638720220 10.81 10.6 1.28 up 2.23E-‐01 RRSL_03384 o Hypothetical membrane associated protein638720221 6.99 7.44 1.23 down 5.27E-‐02 RRSL_03385 o Transposase638720222 7.13 7.9 1.55 down 2.71E-‐02 RRSL_03386 Hypothetical Protein638720224 8.29 9.37 1.91 down 3.20E-‐02 RRSL_03388 Serine/threonine protein phosphatase( EC:3.1.3.16 )638720226 12.43 12.83 1.19 down 2.84E-‐01 RRSL_03390 DNA-‐damage-‐inducible protein J638720227 12.08 12.14 1.05 up 6.51E-‐01 RRSL_03391 yafQ YafQ638720228 9.29 9.54 1.07 down 6.39E-‐01 RRSL_03392 virulence gene repressor RsaL638720229 11.09 10.57 1.58 up 1.34E-‐01 RRSL_03393 Hypothetical Protein638720230 7.11 7.15 1.08 up 7.51E-‐01 RRSL_03394 o c Sigma-‐54-‐dependent transcriptional activator638720231 8.98 9.92 1.74 down 6.67E-‐03 RRSL_03395 o c Methylisocitrate lyase( EC:4.1.3.30 )638720232 11.21 11.75 1.32 down 8.33E-‐02 RRSL_03396 o c Hypothetical Protein( EC:2.3.3.5 )638720233 10.36 11.35 1.8 down 1.34E-‐02 RRSL_03397 o c Aconitate hydratase( EC:4.2.1.3 )638720234 8.69 9.69 1.81 down 1.53E-‐02 RRSL_03398 o c FldA protein638720235 8.87 9.35 1.26 down 1.93E-‐01 RRSL_03399 o Hypothetical Protein638720236 12.6 13.45 1.63 down 6.41E-‐02 RRSL_03400 o c Hypothetical Protein638720239 13.66 13.93 1.09 down 6.53E-‐01 RRSL_03403 o c Hypothetical Protein638720240 7.64 8 1.16 down 4.48E-‐01 RRSL_03404 o Transglutaminase-‐like enzymes, putative cysteine proteases638720241 7.97 8.13 1.01 down 9.48E-‐01 RRSL_03406 o Hypothetical Protein638720242 10.97 11.24 1.1 down 5.14E-‐01 RRSL_03407 o c MoxR protein638720243 9.88 9.78 1.18 up 4.10E-‐01 RRSL_03408 o c Transcriptional regulator, TetR family638720244 9.68 9.94 1.09 down 4.73E-‐01 RRSL_03409 o c Probable transmembrane transporter protein, MFS family638720245 7.77 8.12 1.16 down 6.09E-‐01 RRSL_03410 o c Molybdate-‐binding protein638720246 11.86 11.18 1.76 up 2.74E-‐02 RRSL_03411 Hypothetical protein638720247 8.46 7.8 1.75 up 1.91E-‐03 RRSL_03412 Hypothetical Protein638720248 7.68 7.97 1.11 down 2.57E-‐01 RRSL_03413 Hypothetical Protein638720249 8.37 7.96 1.47 up 2.39E-‐02 RRSL_03414 Hypothetical Protein

638720251 6.94 7.29 1.16 down 6.05E-‐01 RRSL_03416 o c Hypothetical Protein638720252 8.61 8 1.69 up 1.99E-‐01 RRSL_03417 o c Ferrichrome-‐iron receptor638720253 9.62 8.07 3.22 up 5.82E-‐02 RRSL_03418 o c Hypothetical Protein638720254 8 7.72 1.33 up 1.79E-‐01 RRSL_03419 Transcriptional regulators, LysR family638720255 10.73 10.14 1.66 up 2.26E-‐01 RRSL_03420 Hypothetical Protein638720256 9.88 9.51 1.43 up 4.63E-‐01 RRSL_03422 o c 6-‐carboxyhexanoate-‐-‐CoA ligase( EC:6.2.1.14 )638720257 10.49 10.36 1.21 up 2.60E-‐01 RRSL_03423 o c Transcriptional regulator, GntR family638720258 8.59 8.42 1.24 up 3.55E-‐01 RRSL_03424 o Arabinose efflux permease638720259 9.74 10.23 1.27 down 1.51E-‐01 RRSL_03425 o c Hypothetical cytosolic protein638720260 9.82 10.02 1.04 down 8.47E-‐01 RRSL_03426 o c Hypothetical cytosolic protein638720261 11.93 11.34 1.67 up 3.45E-‐03 RRSL_03427 o c Alpha-‐ketoglutarate permease (kgtP1)638720262 8.53 8.82 1.11 down 5.79E-‐01 RRSL_03428 o c Translation initiation inhibitor638720263 9.31 9.69 1.18 down 3.58E-‐01 RRSL_03429 o c Thioesterase( EC:3.1.2.-‐ )638720264 8.12 8.75 1.4 down 7.06E-‐02 RRSL_03430 o c benzoate-‐coenzyme A ligase( EC:6.2.1.25 )638720265 7.06 7.67 1.38 down 3.53E-‐02 RRSL_03431 o c Acyl-‐CoA dehydrogenase, short-‐chain specific( EC:1.3.99.2 )638720266 8.28 8.8 1.3 down 4.35E-‐03 RRSL_03432 o c 1,4-‐dihydroxy-‐2-‐naphthoate synthase/carnithine racemase/enoyl-‐CoA hydratase638720267 9.07 8.97 1.18 up 4.47E-‐01 RRSL_03433 o c Transcriptional regulator, MarR family638720268 8.06 9 1.73 down 4.61E-‐03 RRSL_03434 o c Short chain dehydrogenase638720269 7.91 8.55 1.41 down 5.55E-‐02 RRSL_03435 o c protein with COG1902, NADH: flavin oxidoreductase and COG0654, 2-‐polyprenyl-‐6-‐methoxyphenol hydroxylase & related FAD-‐dependent oxidoreducatse domains638720270 8.41 8.33 1.17 up 2.45E-‐01 RRSL_03436 o Hypothetical Protein638720271 9.84 9.32 1.58 up 2.33E-‐01 RRSL_03437 o Beta-‐lactamase( EC:3.5.2.6 )638720273 11.77 11.43 1.39 up 7.42E-‐02 RRSL_03011 Hypothetical Protein638720275 7.54 7.29 1.31 up 1.83E-‐01 RRSL_03015 Poly(3-‐hydroxyalkanoate) polymerase( EC:2.3.1.-‐ )638720276 8.64 7.8 1.98 up 1.04E-‐01 RRSL_03016 Poly(3-‐hydroxyalkanoate) polymerase( EC:2.3.1.-‐ )638720277 11.48 11.81 1.14 down 5.43E-‐01 RRSL_03018 o c Hypothetical membrane spanning protein638720278 10.39 10.03 1.41 up 2.50E-‐01 RRSL_03020 o c Fosmidomycin resistance protein638720279 8.07 8.28 1.05 down 7.08E-‐01 RRSL_03021 o c Hypothetical Protein638720280 8.2 8.33 1.01 up 9.79E-‐01 RRSL_03024 o c putative sigma factor638720292 8.63 9.23 1.37 down 2.37E-‐01 RRSL_03036 o c Hypothetical Protein638720301 11.36 12.3 1.74 down 1.42E-‐01 RRSL_03046 o c Probable transporter, drug/metabolite (DMT) superfamily638720302 8.72 9.14 1.22 down 2.24E-‐01 RRSL_03047 o c Transcriptional regulator, AraC family638720303 11.97 11.15 1.95 up 1.38E-‐01 RRSL_03048 Hypothetical Protein638720304 9.52 8.71 1.94 up 2.16E-‐01 RRSL_03049 Oxidoreductase( EC:1.1.1.-‐ )638720305 9.55 8.15 2.92 up 1.03E-‐01 RRSL_03050 Transcriptional regulators, LysR family638720306 7.73 7.76 1.08 up 4.67E-‐01 RRSL_03051 Hypothetical Protein638720307 7.88 8.02 1.00E+00 RRSL_03052 Hypothetical Protein638720308 7.45 7.9 1.24 down 2.88E-‐01 RRSL_03053 o Transposase638720309 10.73 9.09 3.44 up 7.74E-‐02 RRSL_03054 Hypothetical Protein638720310 10.16 10.46 1.12 down 5.23E-‐01 RRSL_03055 Bacitracin resistance protein (Putative undecaprenol kinase)( EC:2.7.1.66 )638720311 11.88 12.52 1.41 down 1.07E-‐01 RRSL_03056 o Hypothetical Protein638720312 8.42 7.88 1.6 up 1.26E-‐01 RRSL_03057 o Probable outer membrane cation efflux protein638720313 8.44 8.08 1.42 up 2.08E-‐01 RRSL_03058 o Probable transmembrane cation efflux system protein638720314 9.33 8.22 2.39 up 1.03E-‐01 RRSL_03059 o Transmembrane cation efflux system638720315 10.71 10.64 1.16 up 5.85E-‐01 RRSL_03060 o Hypothetical Protein638720316 9.31 8.41 2.06 up 5.25E-‐02 RRSL_03061 o c Hypothetical Protein638720318 7.69 8.21 1.29 down 1.27E-‐01 RRSL_03063 o c Hypothetical membrane spanning protein638720320 8.12 8.65 1.31 down 2.16E-‐01 RRSL_03066 o c transcriptional regulator638720323 8.48 9.2 1.49 down 2.76E-‐03 RRSL_03069 Transcriptional regulator, AraC family638720324 8.86 9.03 1.02 down 9.04E-‐01 RRSL_03070 Hypothetical Protein638720325 9.06 8.67 1.44 up 8.99E-‐02 RRSL_03071 o c pilK PilK( EC:2.1.1.80 )638720326 10.53 9.74 1.9 up 6.56E-‐02 RRSL_03073 o c Hypothetical Protein638720327 8.69 8.79 1.03 up 7.47E-‐01 RRSL_03074 o c RNA polymerase ECF-‐type sigma factor638720330 12.37 13.42 1.87 down 7.65E-‐03 RRSL_03077 o c Hypothetical Protein638720331 8.22 8.43 1.05 down 8.45E-‐01 RRSL_03078 Hypothetical Protein638720332 11.11 11.78 1.43 down 1.80E-‐01 RRSL_03081 o c Bacterial Peptide Chain Release Factor 3 (RF-‐3)638720334 10.68 11.58 1.7 down 3.88E-‐02 RRSL_03082 Hypothetical Protein638720340 13.83 14.9 1.89 down 5.41E-‐02 RRSL_03089 o c Hypothetical Protein638720343 9.86 10.98 1.96 down 4.03E-‐03 RRSL_03092 o probable transmembrane lipoprotein638720346 10.68 10.67 1.11 up 8.06E-‐01 RRSL_03096 Hypothetical Protein638720347 7.42 8.29 1.66 down 1.40E-‐02 RRSL_03095 o c Hypothetical Protein638720348 10.8 11.29 1.28 down 2.55E-‐01 RRSL_03098 o c Guanine-‐hypoxanthine permease638720349 12.65 13.94 2.22 down 9.04E-‐02 RRSL_02927 o c LSU ribosomal protein L34P638720353 10.63 11.13 1.28 down 9.30E-‐02 RRSL_02931 o c tRNA (5-‐carboxymethylaminomethyl-‐2-‐thiouridylate) synthase638720354 12.1 11.77 1.38 up 1.43E-‐02 RRSL_02932 Hypothetical Protein638720355 8.49 8.4 1.18 up 5.81E-‐01 RRSL_02934 o Protein tyrosine phosphatase( EC:3.1.3.48 )638720356 8.92 8.81 1.19 up 4.26E-‐01 RRSL_02935 Hypothetical Protein638720357 10.16 9.3 2 up 1.41E-‐02 RRSL_02937 Hypothetical Protein638720358 7.64 8.48 1.62 down 1.55E-‐02 RRSL_02938 Hypothetical Protein638720359 13.08 14.16 1.92 down 2.30E-‐02 RRSL_02939 o c SSU ribosomal protein S21P638720363 10.63 10.79 1.01 down 9.32E-‐01 RRSL_02943 o AcrAB operon repressor638720364 8.9 9.52 1.39 down 5.60E-‐02 RRSL_02944 o c Hypothetical Protein638720365 7.56 7.16 1.45 up 1.64E-‐01 RRSL_02945 o c Glutathione reductase( EC:1.6.4.2 )638720367 12.78 12.98 1.04 down 7.38E-‐01 RRSL_02947 o c D-‐3-‐phosphoglycerate dehydrogenase( EC:1.1.1.95 )638720368 12.48 13.51 1.84 down 5.35E-‐02 RRSL_02948 o c Phosphoenolpyruvate carboxykinase (GTP)( EC:4.1.1.32 )638720369 11.84 11.29 1.61 up 2.29E-‐02 RRSL_02949 o c phoB PhoB638720370 11.21 11.12 1.17 up 3.38E-‐01 RRSL_02950 o c Hypothetical Protein

638720371 9.95 9.72 1.3 up 3.05E-‐02 RRSL_02951 o c Hydroxypyruvate isomerase( EC:5.3.1.22 )638720372 9.84 9.43 1.46 up 1.39E-‐02 RRSL_02952 Two-‐component response regulator638720373 8.34 8.47 1.01 up 9.78E-‐01 RRSL_02953 o c Two-‐component sensor histidine kinase( EC:2.7.3.-‐ )638720374 10.37 10.17 1.27 up 6.69E-‐01 RRSL_02954 o c Carbon starvation protein A638720375 9.73 9.97 1.07 down 8.79E-‐01 RRSL_02955 o c Hypothetical Protein638720376 10.51 10.48 1.13 up 3.93E-‐01 RRSL_02956 o c Tetratricopeptide repeat family protein638720377 14.57 15.29 1.49 down 3.60E-‐02 RRSL_02957 o c granule-‐associated protein638720378 9.09 9.55 1.24 down 9.78E-‐02 RRSL_02958 o c Methyltransferase( EC:2.1.1.-‐ )638720379 11.3 11.16 1.21 up 2.18E-‐01 RRSL_02960 o c Homoserine O-‐acetyltransferase( EC:2.3.1.31 )638720380 8.81 9.05 1.07 down 6.25E-‐01 RRSL_02961 o c oxidoreductase; succinate-‐semialdehyde dehydrogenase gabD1( EC:1.2.1.16 )638720382 7.9 8.26 1.16 down 3.47E-‐01 RRSL_02963 o c Transcriptional regulator, GntR family / AMINOTRANSFERASE CLASS-‐I( EC:2.6.1.-‐ )638720386 9.62 10.32 1.48 down 1.06E-‐01 RRSL_02967 o c Hypothetical Protein638720387 8.32 9.25 1.73 down 1.36E-‐02 RRSL_02968 o c Phosphoglycolate phosphatase( EC:3.1.3.18 )638720388 11.11 11.99 1.67 down 3.80E-‐02 RRSL_02970 o c Acetylglutamate kinase( EC:2.7.2.8 )638720389 12.46 12.37 1.18 up 1.74E-‐01 RRSL_02969 o c sigma factor638720390 8.95 9.03 1.04 up 8.60E-‐01 RRSL_02971 o c Hypothetical Protein638720391 7.89 8.78 1.68 down 1.90E-‐02 RRSL_02972 o c Hypothetical Protein638720393 8.46 9.16 1.48 down 2.62E-‐02 RRSL_02974 o c Sensory transduction protein kinase( EC:2.7.3.-‐ )638720395 9.53 10.67 2 down 2.09E-‐02 RRSL_02976 Hypothetical Protein638720397 11.26 11.84 1.35 down 2.55E-‐01 RRSL_02978 Hypothetical Protein638720398 8.76 8.21 1.61 up 5.30E-‐02 RRSL_02979 o Folate transporter638720399 8.18 7.92 1.32 up 3.30E-‐01 RRSL_02980 Hypothetical Protein638720400 8.65 8.77 1.01 up 9.31E-‐01 RRSL_02981 o Hypothetical Protein638720401 11.79 11.52 1.33 up 3.50E-‐01 RRSL_02983 Hypothetical Protein638720402 10.15 9.84 1.38 up 2.24E-‐01 RRSL_02982 FMN-‐dependent NADH-‐azoreductase( EC:1.6.99.2 )638720403 10.07 10.17 1.03 up 8.41E-‐01 RRSL_02984 Transcriptional regulator, TetR family638720404 7.72 8.05 1.14 down 5.81E-‐01 RRSL_02985 Thiosulfate sulfurtransferase( EC:2.8.1.1 )638720405 7.05 7.67 1.39 down 1.43E-‐01 RRSL_02986 Cystathionine beta-‐lyase( EC:4.4.1.8 )638720406 9.78 10.55 1.55 down 2.65E-‐02 RRSL_02988 o Cobyrinic acid a,c-‐diamide synthase( EC:3.-‐ )638720407 10.44 11.19 1.52 down 1.42E-‐02 RRSL_02989 o Cob(I)alamin adenosyltransferase( EC:2.5.1.17 )638720408 8.99 10.11 1.97 down 2.41E-‐03 RRSL_02990 o Low-‐affinity zinc transport protein638720410 8.43 9.54 1.96 down 8.87E-‐03 RRSL_02992 o CbiG protein638720411 8.98 10.02 1.86 down 1.13E-‐02 RRSL_02993 o Precorrin-‐4 C11-‐methyltransferase( EC:2.1.1.133 )638720412 8.91 9.49 1.35 down 7.88E-‐02 RRSL_02994 o Precorrin-‐2 C20-‐methyltransferase( EC:2.1.1.130 )638720413 11.52 11.81 1.11 down 5.12E-‐01 RRSL_02995 o CbiD protein638720414 9.34 10.15 1.59 down 1.13E-‐02 RRSL_02996 o CbiX protein / Precorrin-‐8X methylmutase( EC:5.4.1.2 )638720415 10.25 11.14 1.68 down 2.87E-‐03 RRSL_02997 o Hypothetical Protein638720417 10.33 11.33 1.81 down 9.30E-‐03 RRSL_02999 o CobN protein638720420 6.69 6.9 1.05 down 4.89E-‐01 RRSL_03003 Hypothetical Protein638720421 8.87 8.22 1.73 up 1.37E-‐01 RRSL_03004 Amino acid ABC transporter permease protein638720422 7.76 7.82 1.06 up 8.17E-‐01 RRSL_03006 Hypothetical Protein638720423 11.87 9.27 6.69 up 6.12E-‐02 RRSL_03008 Hypothetical Protein638720424 11.3 12.38 1.91 down 2.09E-‐02 RRSL_03007 o Lipopolysaccharide heptosyltransferase-‐1( EC:2.-‐ )638720425 9.88 10.54 1.43 down 3.56E-‐02 RRSL_03009 o Polysaccharide acetyltransferase( EC:2.3.1.-‐ )638720428 8.62 9.57 1.74 down 9.78E-‐03 RRSL_03190 o c Regulator of nucleoside diphosphate kinase638720429 11.62 12.58 1.76 down 1.92E-‐03 RRSL_03191 o Thiol-‐disulfide isomerase and thioredoxins638720431 14.08 13.85 1.3 up 2.12E-‐01 RRSL_03193 o transposase remnant protein638720431 14.08 13.85 1.3 up 2.12E-‐01 RRSL_03193 o transposase remnant protein638720431 14.08 13.85 1.3 up 2.12E-‐01 RRSL_03193 o transposase remnant protein638720431 14.08 13.85 1.3 up 2.12E-‐01 RRSL_03193 o transposase remnant protein638720432 13.47 13.13 1.39 up 1.35E-‐01 RRSL_03194 o c probable transmembrane638720433 10.16 10.52 1.16 down 1.01E-‐01 RRSL_03195 o c Heat shock protein 15638720434 9.79 10.78 1.8 down 2.60E-‐03 RRSL_03196 o c Ferrochelatase( EC:4.99.1.1 )638720436 9.15 8.55 1.68 up 5.64E-‐02 RRSL_03198 o c Formiminoglutamase( EC:3.5.3.8 )638720439 11.32 8.43 8.15 up 1.06E-‐01 RRSL_03201 o c Histidine utilization repressor638720440 10.85 10.42 1.48 up 3.00E-‐01 RRSL_03203 o c hrcA HrcA638720441 8.28 9.09 1.59 down 9.45E-‐04 RRSL_03204 o c recN RecN638720443 9.87 10.7 1.61 down 2.75E-‐02 RRSL_03206 o c Extracellular subtilisin-‐like protease precursor( EC:3.4.21.-‐ )638720444 11.34 12.48 1.99 down 1.67E-‐02 RRSL_03207 o c Extracellular subtilisin-‐like protease precursor( EC:3.4.21.-‐ )638720445 10.94 10.36 1.65 up 2.23E-‐01 RRSL_03208 o c Hypothetical Protein638720446 8.43 8.71 1.1 down 5.23E-‐01 RRSL_03210 o c Glutamate-‐ammonia-‐ligase adenylyltransferase( EC:2.7.7.42 )638720447 9.04 8.89 1.23 up 1.74E-‐01 RRSL_03209 o c Hypothetical protein638720448 10.17 10.97 1.59 down 2.12E-‐02 RRSL_03211 o Beta-‐ureidopropionase( EC:3.5.1.6 )638720449 10.79 11.53 1.52 down 7.28E-‐02 RRSL_03212 o c TldD protein638720450 10.62 11.4 1.56 down 2.28E-‐02 RRSL_03213 o Phospho-‐2-‐dehydro-‐3-‐deoxyheptonate aldolase( EC:2.5.1.54,EC:4.1.2.15 )638720451 9.26 9.91 1.43 down 3.32E-‐03 RRSL_03215 o c Hypothetical Protein638720452 11.48 11.49 1.1 up 3.79E-‐01 RRSL_03216 o c Mechanosensitive ion channel638720453 11.23 10.33 2.06 up 2.02E-‐01 RRSL_03218 o c Cobalamin adenosyltransferase family protein638720454 10.75 10.95 1.04 down 7.02E-‐01 RRSL_03217 o c (S)-‐2-‐hydroxy-‐acid oxidase chain D( EC:1.1.3.15 )638720455 9.89 9.73 1.23 up 2.15E-‐01 RRSL_03219 o c (S)-‐2-‐hydroxy-‐acid oxidase chain D( EC:1.1.3.15 )638720456 7.32 7.78 1.25 down 1.24E-‐01 RRSL_03221 o c glycolate oxidase (Fe-‐S subunit) GlcF( EC:1.1.3.15 )638720459 8.61 8.8 1.04 down 8.26E-‐01 RRSL_03224 o c Hypothetical Protein638720460 9.74 9.54 1.27 up 4.88E-‐01 RRSL_03225 o c Hypothetical Protein638720461 8.52 9.27 1.53 down 9.82E-‐02 RRSL_03226 o c Transcriptional regulator, DeoR family638720462 11.82 11.44 1.44 up 5.62E-‐02 RRSL_03227 o c Glutathione peroxidase( EC:1.11.1.9 )638720463 10.2 10.94 1.51 down 1.63E-‐02 RRSL_03228 o c PILI ASSEMBLY PROTEIN PILY1-‐related

638720464 11.34 11.18 1.23 up 1.54E-‐01 RRSL_03229 o c Hypothetical Protein638720465 8.33 8.77 1.23 down 1.44E-‐01 RRSL_03230 o c Hypothetical Protein638720466 10.5 10.59 1.03 up 7.99E-‐01 RRSL_03231 o c Hypothetical Protein638720467 10.12 10.42 1.11 down 4.65E-‐01 RRSL_03232 o c Hypothetical Protein638720468 12.25 12.37 1.01 up 8.92E-‐01 RRSL_03233 o c pilE PilE638720469 10.94 11.35 1.21 down 3.43E-‐01 RRSL_03234 o c pilU PilU638720470 11.02 11.85 1.61 down 3.33E-‐02 RRSL_03235 o c PilT638720471 9.43 10.48 1.87 down 5.73E-‐02 RRSL_03236 o c Hypothetical cytosolic protein638720472 8.61 9.24 1.41 down 1.90E-‐01 RRSL_03237 o c Pyrroline-‐5-‐carboxylate reductase( EC:1.5.1.2 )638720473 9.29 10.26 1.78 down 2.46E-‐02 RRSL_03239 o c 4-‐hydroxybenzoate polyprenyltransferase638720474 16 16.58 1.36 down 1.41E-‐02 RRSL_03240 o c Non-‐specific DNA-‐binding protein Dps / Iron-‐binding ferritin-‐like antioxidant protein / Ferroxidase( EC:1.16.3.1 )638720476 10.49 11.34 1.64 down 3.24E-‐02 RRSL_03242 o c Hydrogen peroxide-‐inducible genes activator638720479 8.16 8.79 1.4 down 4.06E-‐02 RRSL_03245 o c Outer membrane porin protein 32 precursor638720480 10.77 11.3 1.31 down 1.97E-‐02 RRSL_03246 o Transporter, drug/metabolite exporter family638720481 8.21 8.73 1.3 down 2.08E-‐01 RRSL_03247 o Aldehyde dehydrogenase( EC:1.2.1.3 )638720482 7.81 8.18 1.17 down 4.93E-‐01 RRSL_03248 o Dihydrodipicolinate synthase( EC:4.2.1.52 )638720483 7.76 7.57 1.25 up 5.85E-‐01 RRSL_03249 o Transporter, MFS superfamily638720484 7.67 7.61 1.15 up 5.71E-‐01 RRSL_03250 o Oxidoreductase( EC:1.-‐ )638720485 7.86 7.75 1.19 up 7.08E-‐01 RRSL_03251 Hypothetical Protein638720486 10.82 11.55 1.51 down 2.33E-‐02 RRSL_03252 o Transcriptional regulator, GntR family638720487 9.2 9.42 1.05 down 8.29E-‐01 RRSL_03253 Hypothetical Protein638720488 9.44 9.26 1.25 up 2.31E-‐01 RRSL_03254 Hypothetical Protein638720489 7.48 7.66 1.03 down 8.57E-‐01 RRSL_03255 N-‐carbamoyl-‐L-‐amino acid amidohydrolase( EC:3.5.1.-‐ )638720490 9.66 9.18 1.55 up 2.75E-‐01 RRSL_03256 Putative diaminopropionate ammonia-‐lyase( EC:4.3.1.15 )638720491 7.65 7.18 1.53 up 3.00E-‐01 RRSL_03257 o Transcriptional regulators, LysR family638720492 7.47 7.28 1.26 up 5.06E-‐01 RRSL_03258 o Alanine racemase( EC:5.1.1.1 )638720493 10.47 9.3 2.48 up 7.49E-‐02 RRSL_03260 o c Hypothetical Protein638720494 7.38 8.29 1.69 down 1.07E-‐02 RRSL_03262 o c ATP-‐dependent DNA helicase recG( EC:3.6.1.-‐ )638720495 9.09 10.05 1.77 down 9.53E-‐03 RRSL_03263 o c S-‐adenosylmethionine:tRNA ribosyltransferase-‐isomerase( EC:5.-‐ )638720496 10.87 11.64 1.54 down 7.75E-‐03 RRSL_03264 o c Queuine tRNA-‐ribosyltransferase( EC:2.4.2.29 )638720497 14.69 15.57 1.66 down 4.16E-‐03 RRSL_03265 Protein translocase subunit YajC638720498 7.89 7.17 1.82 up 1.38E-‐01 RRSL_02236 Peptide synthetase638720499 11.24 10.3 2.12 up 9.14E-‐02 RRSL_02238 o Phage protein638720500 11.8 10.08 3.65 up 5.96E-‐02 RRSL_02239 Hypothetical Protein638720501 8.36 8.57 1.05 down 7.25E-‐01 RRSL_02240 o Hypothetical Protein638720502 11.77 10.93 1.97 up 9.81E-‐02 RRSL_02241 o Hypothetical Protein638720503 11.11 10.77 1.4 up 2.72E-‐01 RRSL_02242 o Hypothetical Protein638720504 10.78 11.02 1.07 down 6.59E-‐01 RRSL_02243 o 1-‐aminocyclopropane-‐1-‐carboxylate deaminase( EC:3.5.99.7,EC:4.1.99.4 )638720505 7.83 7.63 1.27 up 1.06E-‐01 RRSL_02244 o 3-‐hydroxyisobutyryl-‐CoA hydrolase( EC:3.1.2.4 )638720506 8.18 7.54 1.72 up 2.10E-‐02 RRSL_02245 o 3-‐hydroxybutyryl-‐CoA dehydratase( EC:4.2.1.55 )638720509 8.33 7.87 1.51 up 6.10E-‐02 RRSL_02248 Acetyl-‐coenzyme A synthetase( EC:6.2.1.1 )638720510 8.63 8.32 1.37 up 6.63E-‐02 RRSL_02249 o Transcriptional regulator, AraC family638720511 8.12 8.08 1.14 up 2.81E-‐01 RRSL_02250 NAD-‐specific glutamate dehydrogenase( EC:1.4.1.2 )638720512 11.15 10.85 1.35 up 1.83E-‐01 RRSL_02251 Hypothetical Protein638720513 10.12 10.71 1.37 down 7.32E-‐02 RRSL_02252 Hypothetical Protein638720515 9.49 9.95 1.25 down 1.41E-‐01 RRSL_02254 o c Transcriptional regulator, MarR family638720516 9.38 9.43 1.06 up 5.11E-‐01 RRSL_02255 o c corA CorA638720517 8.82 9.21 1.19 down 4.17E-‐02 RRSL_02256 o c DNA-‐3-‐methyladenine glycosylase( EC:3.2.2.20 )638720518 9.84 9.38 1.52 up 2.08E-‐01 RRSL_02257 o c Transporter, MFS superfamily638720519 8.21 8.13 1.17 up 4.45E-‐01 RRSL_02258 o Hypothetical cytosolic protein638720520 12.03 11.57 1.52 up 1.75E-‐01 RRSL_02259 Hypothetical Protein638720521 7.92 8.99 1.9 down 5.68E-‐03 RRSL_02260 o oprM OprM638720522 8.72 8.91 1.03 down 8.33E-‐01 RRSL_02262 o Acriflavin resistance plasma membrane protein638720523 7.19 7.98 1.57 down 6.72E-‐02 RRSL_02263 o c Enoyl-‐CoA hydratase( EC:4.2.1.17 )638720525 6.27 6.9 1.41 down 3.37E-‐02 RRSL_02265 o c Hypothetical exported protein638720526 9.71 7.96 3.71 up 7.30E-‐02 RRSL_02266 o c Putative periplasmic protein638720527 7.74 7.44 1.35 up 1.68E-‐01 RRSL_02267 o Putative periplasmic protein638720529 10.29 10.46 1.02 down 9.41E-‐01 RRSL_02269 o metR MetR638720530 9.82 9.86 1.07 up 7.49E-‐01 RRSL_02270 o c Pyridoxamine 5'-‐phosphate oxidase( EC:1.4.3.5 )638720531 9.7 9.89 1.03 down 9.02E-‐01 RRSL_02271 o Hypothetical Protein638720532 8.23 8.76 1.3 down 3.29E-‐01 RRSL_02272 o c Indole-‐3-‐glycerol phosphate synthase( EC:4.1.1.48 )638720533 7.88 8.26 1.19 down 4.47E-‐01 RRSL_02273 o c Anthranilate phosphoribosyltransferase( EC:2.4.2.18 )638720534 8.96 9.9 1.75 down 2.71E-‐02 RRSL_02274 o Trimethylamine dehydrogenase( EC:1.5.8.2 )638720536 10.13 10.27 1 up 9.91E-‐01 RRSL_02276 o c Transporter, drug/metabolite exporter family638720543 8.6 7.86 1.85 up 2.76E-‐02 RRSL_02283 o c nahR NahR638720544 8.28 9.09 1.58 down 2.89E-‐02 RRSL_02285 o RtcB protein638720547 10.01 10.11 1.03 up 8.33E-‐01 RRSL_02289 o c Transcriptional regulator, IclR family638720555 11.99 11.28 1.81 up 3.74E-‐02 RRSL_02865 o c Disulfide bond formation protein B638720556 8.46 9.24 1.56 down 2.39E-‐04 RRSL_02867 o c polyl aminopeptidase( EC:3.4.11.5 )638720557 9.54 9.78 1.07 down 7.01E-‐01 RRSL_02868 o hypothetical protein638720558 10.04 10.59 1.32 down 9.71E-‐02 RRSL_02870 o c 3-‐oxoacyl-‐[acyl-‐carrier-‐protein] synthase III( EC:2.3.1.41 )638720559 10.64 11.23 1.37 down 1.18E-‐01 RRSL_02872 o Putative permease638720560 9.44 10.03 1.37 down 1.11E-‐01 RRSL_02873 o Fimbriae V protein638720561 8.01 8.08 1.05 up 7.64E-‐01 RRSL_02875 Transcriptional regulators, LysR family638720562 8.89 8.85 1.13 up 6.28E-‐01 RRSL_02876 o oxidoreductase, aldo/keto reductase family638720563 9.56 8.86 1.79 up 6.67E-‐02 RRSL_02877 o Bicyclomycin resistance protein

638720564 8.67 9.12 1.24 down 9.44E-‐02 RRSL_02878 hypothetical protein638720565 8.65 8.63 1.12 up 6.44E-‐01 RRSL_02879 o ABC transport system substrate-‐binding protein638720566 7.68 7.96 1.1 down 6.13E-‐01 RRSL_02882 o Aconitate hydratase( EC:4.2.1.3 )638720567 7.46 8.26 1.58 down 8.82E-‐02 RRSL_02881 o hypothetical protein638720568 9.25 10.05 1.58 down 5.12E-‐02 RRSL_02883 hypothetical protein638720570 8.91 9.62 1.48 down 8.79E-‐02 RRSL_02885 hypothetical protein638720571 10.19 10.76 1.34 down 2.61E-‐01 RRSL_02886 o c hypothetical protein638720572 11.83 11.94 1.03 up 8.71E-‐01 RRSL_02887 hypothetical protein638720574 10.96 11.61 1.42 down 5.12E-‐02 RRSL_02889 hypothetical protein638720575 11.55 12.49 1.75 down 1.62E-‐01 RRSL_RNA028 ( tRNA )638720576 10.66 11.79 1.98 down 5.22E-‐02 RRSL_02890 o c Cytochrome c555638720579 8.95 9.72 1.54 down 3.19E-‐02 RRSL_02893 o hypothetical protein638720580 11.43 11.8 1.17 down 1.69E-‐01 RRSL_02894 o hypothetical protein638720581 9.56 8.88 1.76 up 1.44E-‐01 RRSL_02895 hypothetical protein638720582 8.09 8.43 1.15 down 5.62E-‐01 RRSL_02896 Lipase( EC:3.1.1.3 )638720583 9.74 9.16 1.64 up 2.68E-‐01 RRSL_02897 Short chain dehydrogenase638720584 9.88 9.13 1.85 up 2.86E-‐01 RRSL_02898 Cyclohexanone monooxygenase( EC:1.14.13.22 )638720585 10.82 9.27 3.22 up 1.08E-‐01 RRSL_02899 o c hypothetical protein638720586 7.71 7.49 1.29 up 3.04E-‐01 RRSL_02900 o c Two-‐component response regulator638720587 9.99 10.54 1.33 down 1.95E-‐02 RRSL_02901 o c czcD CzcD638720588 8.75 8.25 1.56 up 1.43E-‐01 RRSL_02902 hypothetical protein638720590 8 7.67 1.39 up 5.35E-‐02 RRSL_02904 o c hypothetical protein638720593 9.94 9.1 1.98 up 1.79E-‐01 RRSL_02907 o c Multidrug resistance protein B638720594 7.91 8.19 1.1 down 6.19E-‐01 RRSL_02908 o c Mechanosensitive ion channel638720596 10.32 12.04 2.97 down 2.03E-‐01 RRSL_02911 hypothetical protein638720598 10.4 10.72 1.13 down 5.55E-‐01 RRSL_02914 o Transcriptional regulator, AraC family638720599 10.09 10.68 1.36 down 1.19E-‐02 RRSL_02913 o Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638720600 10.16 10 1.23 up 4.74E-‐01 RRSL_02915 o c hypothetical protein638720601 11.37 11.11 1.32 up 2.17E-‐01 RRSL_02917 o hypothetical protein638720602 10.9 10.22 1.77 up 3.53E-‐02 RRSL_02918 o c Mannose-‐6-‐phosphate isomerase( EC:5.3.1.8 )638720603 7.81 8.37 1.33 down 4.80E-‐03 RRSL_02919 o c conserved hypothetical protein638720604 9.9 10.2 1.12 down 3.07E-‐01 RRSL_02920 o hypothetical protein638720605 9.97 9.94 1.12 up 2.48E-‐01 RRSL_02921 o hypothetical protein638720606 8.81 8.75 1.15 up 4.16E-‐01 RRSL_02922 o c hypothetical protein638720612 9.33 10.01 1.45 down 4.75E-‐02 RRSL_02787 o c ATP-‐dependent DNA helicase rep( EC:3.6.1.-‐ )638720616 9.54 9.16 1.43 up 3.50E-‐02 RRSL_02791 o solR SolR638720617 10.03 9.28 1.85 up 2.93E-‐02 RRSL_02792 o solI SolI638720618 8.77 8 1.87 up 1.47E-‐01 RRSL_02793 o Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638720620 8.52 7.97 1.61 up 1.19E-‐01 RRSL_02795 o c Pyruvate kinase( EC:2.7.1.40 )638720621 7.49 7.14 1.41 up 1.68E-‐01 RRSL_02796 o c Glycerate dehydrogenase / Hydroxypyruvate reductase( EC:1.1.1.29,EC:1.1.1.81 )638720622 8.61 7.74 2.02 up 1.03E-‐01 RRSL_02797 o c 2-‐hydroxy-‐3-‐oxopropionate reductase( EC:1.1.1.60 )638720623 9.02 7.97 2.27 up 1.19E-‐01 RRSL_02798 o c Hydroxypyruvate isomerase( EC:5.3.1.22 )638720624 8.41 7.73 1.76 up 1.84E-‐01 RRSL_02799 o c Glyoxylate carboligase( EC:4.1.1.47 )638720625 8.8 8.7 1.18 up 4.31E-‐01 RRSL_02800 o c Transcriptional regulators, LysR family638720626 9.66 9.8 1 down 9.98E-‐01 RRSL_02801 o Hypothetical Protein638720627 10.51 10.15 1.42 up 3.34E-‐01 RRSL_02802 o Transcriptional regulator638720628 8.29 9.37 1.92 down 3.43E-‐03 RRSL_02803 o c Xaa-‐Pro dipeptidase( EC:3.4.13.9 )638720631 10.59 10.82 1.07 down 6.84E-‐01 RRSL_02807 o c Allantoicase( EC:3.5.3.4 )638720632 8.6 8.64 1.08 up 3.32E-‐01 RRSL_02808 Ureidoglycolate hydrolase( EC:3.5.3.19 )638720633 9.12 9.01 1.19 up 1.84E-‐01 RRSL_02809 o c Succinyl-‐diaminopimelate desuccinylase( EC:3.5.1.18 )638720635 9.73 9.85 1.02 up 8.54E-‐01 RRSL_02811 o c Arsenate reductase family protein638720637 9.06 9.41 1.16 down 2.36E-‐01 RRSL_02813 o c Hypothetical Protein638720638 10.65 11.12 1.25 down 1.47E-‐01 RRSL_02814 o c Hypothetical Protein638720639 9.26 10 1.52 down 2.00E-‐01 RRSL_02815 o c Rare lipoprotein A638720640 8.72 9.35 1.4 down 8.57E-‐02 RRSL_02816 o c corrin/porphyrin methyltransferase( EC:2.1.1.-‐ )638720641 13.89 14.04 1 down 9.91E-‐01 RRSL_02817 o c Hypothetical Protein638720642 9.85 10.79 1.74 down 3.24E-‐03 RRSL_02819 o c Hypothetical Protein638720643 10.15 10.39 1.07 down 7.91E-‐01 RRSL_02820 o c soxF SoxF( EC:1.8.5.-‐ )638720644 11.07 10.08 2.19 up 8.89E-‐02 RRSL_02821 o c Cysteine/acetylserine efflux protein638720645 10.06 11.09 1.85 down 3.55E-‐03 RRSL_02822 o c Cytochrome c551638720646 13.19 13.29 1.02 up 7.09E-‐01 RRSL_02823 o c Hypothetical transmembrane protein638720647 11.48 11.71 1.06 down 3.51E-‐01 RRSL_02824 o c Hypothetical Protein638720648 9.46 10.35 1.68 down 2.54E-‐03 RRSL_02825 o c Hypothetical Protein638720649 9.79 10.37 1.35 down 2.59E-‐02 RRSL_02826 o c Hypothetical Protein638720650 9.67 10.12 1.24 down 3.85E-‐03 RRSL_02827 o c Hypothetical Protein638720651 8.9 9.54 1.41 down 5.19E-‐02 RRSL_02828 o c tlpA TlpA638720652 11.39 10.65 1.85 up 2.45E-‐01 RRSL_RNA027 ( tRNA )638720654 8.92 9.81 1.68 down 2.95E-‐02 RRSL_02832 o Hypothetical Protein638720655 9.42 9.22 1.27 up 4.01E-‐01 RRSL_02834 Hypothetical Protein638720656 10.98 11.42 1.23 down 2.48E-‐01 RRSL_02835 o Hypothetical membrane spanning protein638720659 8.44 9.16 1.49 down 1.04E-‐02 RRSL_02838 o Spermidine synthase( EC:2.5.1.16 )638720660 8.12 8.44 1.13 down 7.08E-‐01 RRSL_02839 livF LivF638720661 9.5 7.72 3.8 up 7.17E-‐02 RRSL_02841 livM LivM638720664 12.6 13.06 1.25 down 2.66E-‐01 RRSL_02844 o Hypothetical membrane spanning protein638720665 8.04 8.48 1.23 down 6.88E-‐02 RRSL_02845 o Hypothetical Protein638720666 10 9.98 1.12 up 5.08E-‐01 RRSL_02846 o Hypothetical Protein

638720667 11.03 11.29 1.09 down 6.31E-‐01 RRSL_02847 o Hypothetical Protein638720668 9.33 9.47 1 up 9.83E-‐01 RRSL_02848 o putative type-‐4 fimbrial pilin related signal peptide protein638720669 7.27 7.61 1.14 down 3.44E-‐01 RRSL_02848_5 o pilV PilV638720670 8.23 7.7 1.59 up 1.16E-‐01 RRSL_02849 o pilW PilW638720671 7.85 7.77 1.17 up 5.23E-‐01 RRSL_02850 o pilX PilX638720672 9.18 9.12 1.15 up 4.75E-‐01 RRSL_02851 o PILI ASSEMBLY PROTEIN, PilY1638720673 8.1 9.08 1.79 down 1.11E-‐02 RRSL_02852 o pilE PilE638720675 8.82 8.58 1.31 up 2.02E-‐01 RRSL_02854 o Multidrug resistance protein B638720676 7.27 7.25 1.12 up 5.15E-‐01 RRSL_02855 o Hypothetical Protein638720678 11.19 11.8 1.38 down 2.82E-‐02 RRSL_02710 o c Enoyl-‐CoA hydratase( EC:4.2.1.17 )638720679 12.15 12.26 1.03 up 8.76E-‐01 RRSL_02711 o c Enoyl-‐CoA hydratase( EC:4.2.1.17 )638720681 14.33 14.58 1.08 down 8.23E-‐01 RRSL_02714 o c membrane-‐bound lytic murein transglycosylase a( EC:3.2.1.-‐ )638720682 11.46 12.34 1.67 down 6.98E-‐03 RRSL_02715 o ApaG protein638720683 10.67 11.72 1.89 down 1.44E-‐02 RRSL_02716 o c Ribulose-‐phosphate 3-‐epimerase( EC:5.1.3.1 )638720684 9.8 10.51 1.49 down 3.98E-‐02 RRSL_02717 o c Phosphoglycolate phosphatase gph( EC:3.1.3.18 )638720686 12.75 13.42 1.44 down 7.70E-‐03 RRSL_02719 o c Anthranilate synthase component II / Para-‐aminobenzoate synthase glutamine amidotransferase component II( EC:4.1.3.-‐,EC:4.1.3.27 )638720688 12.66 13.52 1.65 down 4.60E-‐03 RRSL_02721 o c Anthranilate phosphoribosyltransferase( EC:2.4.2.18 )638720691 10.22 11.28 1.89 down 1.41E-‐02 RRSL_02724 o c Uracil-‐DNA glycosylase( EC:3.2.2.-‐ )638720692 9.3 9.54 1.07 down 7.90E-‐01 RRSL_02725 o c Integral membrane protein638720693 9.55 10.16 1.39 down 2.19E-‐02 RRSL_02726 o c Trypsin-‐like serine proteases, typically periplasmic, contain C-‐terminal PDZ domain638720694 11.12 10.47 1.72 up 1.48E-‐02 RRSL_02727 o c Alcohol dehydrogenase( EC:1.1.1.1 )638720695 11.1 11.6 1.29 down 1.21E-‐01 RRSL_02728 o c Thiol:disulfide interchange protein DsbC638720696 10.79 11.29 1.29 down 1.25E-‐02 RRSL_02729 o c Putative monooxygenase VisC638720698 8.87 8.45 1.48 up 1.08E-‐01 RRSL_02731 o c Hypothetical Protein638720700 10.92 10.23 1.78 up 2.42E-‐02 RRSL_02733 o c Hypothetical Protein638720702 10.76 10.94 1.03 down 9.10E-‐01 RRSL_02735 o c Hypothetical Protein638720703 11.52 11.79 1.09 down 4.17E-‐01 RRSL_02736 o c Glutamyl-‐tRNA reductase( EC:1.2.1.-‐ )638720704 11.37 11.63 1.09 down 5.21E-‐01 RRSL_02737 o c Bacterial Peptide Chain Release Factor 1 (RF-‐1)638720705 10.98 11.8 1.6 down 1.29E-‐01 RRSL_02738 o c Hypothetical Protein638720706 9.86 10.3 1.23 down 9.81E-‐02 RRSL_02739 o c Peptide release factor-‐glutamine N5-‐methyltransferase( EC:2.1.1.-‐ )638720707 10.95 11.96 1.83 down 1.59E-‐02 RRSL_02740 o c 3-‐polyprenyl-‐4-‐hydroxybenzoate decarboxylase ubiX( EC:4.1.1.-‐ )638720708 11.39 11.7 1.12 down 5.39E-‐01 RRSL_02741 o Hypothetical transmembrane protein638720710 11.18 12 1.61 down 4.45E-‐03 RRSL_02743 o c signal peptide, periplasmic glucans biosynthesis protein mdoG638720711 9.44 10.19 1.53 down 2.36E-‐02 RRSL_02744 o c Periplasmic glucan glucosyltransferase( EC:2.4.1.-‐ )638720712 11.16 11.34 1.03 down 7.61E-‐01 RRSL_02745 Signal peptide protein638720713 11.76 10.92 1.97 up 1.07E-‐02 RRSL_02746 o c Hypothetical Protein638720714 9.69 10.39 1.47 down 1.55E-‐01 RRSL_02747 o c Hypothetical cytosolic protein638720716 10.64 11.7 1.89 down 8.93E-‐03 RRSL_02749 o c cyoD CyoD638720717 11.06 12.17 1.96 down 1.39E-‐02 RRSL_02750 o c Cytochrome O ubiquinol oxidase subunit III( EC:1.10.3.-‐ )638720718 13.11 13.85 1.52 down 3.33E-‐02 RRSL_02751 o c Cytochrome O ubiquinol oxidase subunit I( EC:1.10.3.-‐ )638720719 13.25 13.53 1.1 down 5.57E-‐01 RRSL_02752 o c Cytochrome O ubiquinol oxidase subunit II( EC:1.10.3.-‐ )638720720 9.76 10.19 1.22 down 2.29E-‐01 RRSL_02753 o c Hypothetical Protein638720722 9.59 9.56 1.12 up 7.60E-‐01 RRSL_02755 o c Ferrichrome-‐iron receptor638720723 8.42 8.69 1.09 down 4.33E-‐01 RRSL_02756 o Gamma-‐glutamyltranspeptidase( EC:2.3.2.2 )638720724 9.66 9.83 1.02 down 9.16E-‐01 RRSL_02757 o c outer membrane heme receptor638720725 10.97 10.86 1.19 up 2.13E-‐01 RRSL_02758 o c Sensor protein luxN( EC:2.7.3.-‐ )638720726 12.47 12.95 1.26 down 2.39E-‐01 RRSL_RNA026 ( tRNA )638720727 13.74 14.49 1.52 down 4.08E-‐02 RRSL_02759 o c Stringent starvation protein B638720729 12.01 12.78 1.55 down 2.31E-‐01 RRSL_02761 o c Cytochrome c1638720730 14.85 14.73 1.2 up 7.58E-‐03 RRSL_02762 o c Cytochrome b( EC:1.10.2.2 )638720731 13.86 13.97 1.02 up 9.19E-‐01 RRSL_02763 o c petA PetA( EC:1.10.2.2 )638720732 12.61 13.13 1.3 down 2.74E-‐01 RRSL_02764 o c Large-‐conductance mechanosensitive channel638720733 11.03 11.98 1.75 down 8.21E-‐02 RRSL_02765 o c NIF3-‐related protein638720735 16.87 17.09 1.06 down 1.92E-‐01 RRSL_02767 o c Outer membrane porin protein 32 precursor638720736 10.37 10.11 1.32 up 1.11E-‐01 RRSL_02769 o c Iron(III)-‐binding protein638720737 8.68 9.16 1.26 down 2.23E-‐01 RRSL_02768 o c Transcriptional regulatory protein638720738 8.77 9.4 1.4 down 1.28E-‐02 RRSL_02770 o c Two component system histidine kinase( EC:2.7.3.-‐ )638720742 9.75 9.95 1.04 down 8.27E-‐01 RRSL_02774 o c tatC TatC638720744 12.27 13.24 1.77 down 3.80E-‐02 RRSL_02776 o c tatA TatA638720745 14.39 14.58 1.03 down 9.03E-‐01 RRSL_02777 o c Hypothetical Protein638720748 12.65 13.54 1.68 down 7.53E-‐03 RRSL_02780 o c Imidazole glycerol phosphate synthase subunit hisF( EC:4.1.3.-‐ )638720749 14.7 15.39 1.46 down 1.83E-‐03 RRSL_02781 o c Phosphoribosylformimino-‐5-‐aminoimidazole carboxamide ribotide isomerase( EC:5.3.1.16 )638720750 12.41 12.63 1.05 down 6.41E-‐01 RRSL_02782 Amidotransferase hisH( EC:2.4.2.-‐ )638720751 10.77 11.5 1.51 down 3.86E-‐02 RRSL_02783 o c Imidazoleglycerol-‐phosphate dehydratase( EC:4.2.1.19 )638720752 11 11.68 1.46 down 3.25E-‐03 RRSL_02784 Histidinol-‐phosphate aminotransferase( EC:2.6.1.9 )638720753 12.38 12.85 1.26 down 4.22E-‐01 RRSL_02043 Core protein638720754 10.58 10.63 1.07 up 6.54E-‐01 RRSL_02044 Hypothetical Protein638720759 8.62 9.7 1.92 down 4.31E-‐02 RRSL_02049 o c Zinc metalloprotease( EC:3.4.24.-‐ )638720760 11.32 11.76 1.23 down 2.41E-‐01 RRSL_02050 o c Hypothetical protein638720762 15.22 16.28 1.88 down 5.13E-‐03 RRSL_02052 o c 10 kDa chaperonin GROES638720765 8.18 9.09 1.7 down 1.21E-‐01 RRSL_02055 o Hypothetical Protein638720766 9.81 10.96 2.01 down 8.17E-‐02 RRSL_02056 Hypothetical Protein638720769 10.1 9.96 1.22 up 4.36E-‐01 RRSL_02059 Hypothetical Protein638720770 7.91 8.54 1.4 down 2.00E-‐01 RRSL_02060 drug/metabolite transporter (DMT) permease638720771 9.87 10.86 1.8 down 5.71E-‐02 RRSL_02061 Transcriptional regulators, LysR family638720773 9.3 9.49 1.03 down 9.12E-‐01 RRSL_02064 Hypothetical Protein

638720774 16.67 16.33 1.4 up 5.93E-‐04 RRSL_02065 o cbhA CbhA638720775 11.09 10.5 1.66 up 2.36E-‐01 RRSL_02066 Hypothetical Protein638720778 11.43 11.51 1.04 up 8.58E-‐01 RRSL_02070 Hypothetical Protein638720779 11.52 11.45 1.16 up 3.74E-‐01 RRSL_02071 Deoxyuridylate hydroxymethyltransferase( EC:2.1.2.-‐ )638720781 7.91 7.82 1.17 up 3.57E-‐01 RRSL_02074 probable hemagglutinin-‐related signal peptide protein638720782 7.77 7.75 1.11 up 4.40E-‐01 RRSL_02075 Hemolysin activator protein precursor638720783 9.8 10.18 1.18 down 3.29E-‐01 RRSL_02076 o Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638720784 7.82 7.71 1.19 up 3.48E-‐01 RRSL_02077 Hypothetical Protein638720785 10.35 10.22 1.2 up 1.99E-‐01 RRSL_02078 hypothetical638720786 10.28 10.09 1.26 up 2.19E-‐01 RRSL_02079 o transposase remnant638720787 8.48 8.94 1.24 down 2.00E-‐01 RRSL_02080 Cyclopropane-‐fatty-‐acyl-‐phospholipid synthase( EC:2.1.1.79 )638720788 7.34 7.39 1.07 up 7.70E-‐01 RRSL_02081 Hypothetical Protein638720789 8.09 8.09 1.1 up 4.74E-‐01 RRSL_02082 o c Hypothetical protein638720790 9.57 9.31 1.32 up 9.66E-‐02 RRSL_02083 o c probable two-‐component response regulator638720791 7.96 8.31 1.15 down 5.95E-‐01 RRSL_02084 o c Two component system histidine kinase( EC:2.7.3.-‐ )638720792 9.04 8.97 1.16 up 4.25E-‐01 RRSL_02085 FldX protein638720793 7.51 7.66 1.01 down 9.21E-‐01 RRSL_02086 Outer membrane porin protein 32 precursor638720794 7 7.21 1.05 down 5.40E-‐01 RRSL_02087 4-‐carboxy-‐4-‐hydroxy-‐2-‐oxoadipate aldolase( EC:4.1.3.17 )638720795 7.94 7.72 1.28 up 3.08E-‐01 RRSL_02088 4-‐oxalomesaconate hydratase( EC:4.2.1.-‐ )638720796 7.88 8.14 1.08 down 7.12E-‐01 RRSL_02089 Transcriptional regulators, LysR family638720797 9.57 9.26 1.37 up 1.07E-‐01 RRSL_02091 4-‐hydroxybenzoate transporter638720798 9.32 9.49 1.02 down 8.69E-‐01 RRSL_02092 Hypothetical protein638720799 11 11.56 1.34 down 2.44E-‐01 RRSL_02093 o c putative acyl-‐CoA transferases/carnitine dehydratase638720801 9.43 8.93 1.56 up 1.34E-‐01 RRSL_02096 o c Hypothetical membrane associated protein638720802 8.77 8.69 1.17 up 2.92E-‐01 RRSL_02097 o c Hypothetical Protein638720810 8.4 7.83 1.64 up 5.56E-‐02 RRSL_02105 o Probable transmembrane methyl-‐accepting chemotaxis protein638720811 11.26 10.72 1.6 up 2.29E-‐02 RRSL_02291 Hypothetical Protein638720817 8.68 8.11 1.64 up 7.19E-‐02 RRSL_02298 o Hypothetical Protein638720818 9.56 9.04 1.58 up 1.42E-‐02 RRSL_02299 Hypothetical Protein638720820 7.43 6.96 1.52 up 4.31E-‐02 RRSL_02301 Hypothetical Protein638720821 10.4 11.37 1.78 down 5.39E-‐02 RRSL_02302 o Hypothetical Protein638720822 11.23 11.13 1.18 up 1.18E-‐01 RRSL_02303 o c Hypothetical Protein638720823 12.45 11.6 1.99 up 1.91E-‐03 RRSL_02304 o c Hypothetical Protein638720824 8.58 8.67 1.03 up 8.78E-‐01 RRSL_02305 Hypothetical Protein638720825 9.58 8.35 2.6 up 1.15E-‐01 RRSL_02306 Hypothetical Protein638720826 10.43 10.45 1.08 up 8.21E-‐01 RRSL_02307 o c Hypothetical Protein638720827 9.78 9.32 1.52 up 1.04E-‐01 RRSL_02308 o c Thiosulfate sulfurtransferase( EC:2.8.1.1 )638720828 8.07 8.02 1.14 up 1.98E-‐01 RRSL_02309 o c fliK FliK638720829 8.11 7.84 1.33 up 1.46E-‐01 RRSL_02310 o c fliI FliI( EC:3.6.3.14 )638720832 8.96 8.28 1.77 up 9.70E-‐02 RRSL_02313 o c fliF FliF638720835 7.63 7.38 1.31 up 2.17E-‐01 RRSL_02316 o Hypothetical protein638720836 7.82 8.05 1.06 down 8.15E-‐01 RRSL_02317 o Transcriptional regulator, MarR family638720841 9.75 10.26 1.29 down 6.11E-‐03 RRSL_02322 o c Transcriptional regulator, luxR family638720842 9.38 9.01 1.43 up 5.55E-‐02 RRSL_02323 o c Signal transduction protein EAL638720844 9.76 9.15 1.68 up 1.36E-‐01 RRSL_02325 o c fliM FliM638720845 9.06 8.38 1.77 up 1.82E-‐03 RRSL_02326 o c fliN FliN638720849 8.56 7.72 1.97 up 1.29E-‐02 RRSL_02330 o c fliR FliR638720850 10.83 10.83 1.11 up 3.43E-‐01 RRSL_02333 o c Hypothetical protein638720852 9 8.36 1.72 up 3.92E-‐02 RRSL_02335 o c flgK FlgK638720855 8.54 8.45 1.18 up 3.64E-‐01 RRSL_02338 o c flgH FlgH638720857 11.02 10.29 1.83 up 5.19E-‐02 RRSL_02340 o c flgF FlgF638720858 11.8 11.22 1.65 up 9.01E-‐02 RRSL_02341 o c flgE FlgE638720861 9.69 9.27 1.48 up 3.38E-‐02 RRSL_02344 o c flgB FlgB638720862 9.26 8.99 1.32 up 1.83E-‐01 RRSL_02345 o c flgA FlgA638720863 10.89 10.35 1.61 up 6.10E-‐02 RRSL_02346 o c flgM FlgM638720864 10.41 9.69 1.82 up 1.30E-‐02 RRSL_02347 o c flgN FlgN638720865 9.39 8.67 1.81 up 5.58E-‐02 RRSL_02348 o narP NarP638720867 10.72 11.07 1.15 down 5.29E-‐01 RRSL_02350 o Transcriptional regulator, GntR family638720868 12.74 12.58 1.23 up 4.50E-‐01 RRSL_02351 o H-‐NS-‐like proteins638720870 11.37 11.48 1.03 up 9.36E-‐01 RRSL_02353 Hypothetical Protein638720871 10.74 10.37 1.42 up 2.91E-‐01 RRSL_02354 o Hypothetical Protein638720872 13.42 12.57 1.99 up 2.21E-‐02 RRSL_02355 Bacterial Protein Translation Initiation Factor 1 (IF-‐1)638720874 9.31 10.12 1.59 down 1.51E-‐01 RRSL_02358 o Hypothetical Protein638720875 7.82 7.62 1.27 up 4.20E-‐01 RRSL_02359 o Hypothetical Protein638720876 9.52 8.91 1.68 up 5.53E-‐02 RRSL_02360 o Hypothetical Protein638720878 7.53 7.71 1.03 down 8.60E-‐01 RRSL_02363 2-‐hydroxymuconic semialdehyde hydrolase( EC:3.7.1.9 )638720879 7.59 8.24 1.42 down 9.77E-‐02 RRSL_02365 o c Hypothetical Protein638720880 9.57 9.42 1.22 up 6.02E-‐01 RRSL_02366 o c Hypothetical Protein638720881 12.92 13.01 1.04 up 7.68E-‐01 RRSL_02367 o c Hypothetical cytosolic protein638720883 10.5 9.71 1.9 up 2.44E-‐01 RRSL_02370 o c tctA TctA638720884 11.05 11.44 1.19 down 5.23E-‐01 RRSL_02371 o c Hypothetical Protein638720885 11.53 11.57 1.08 up 7.49E-‐01 RRSL_02372 o c Hypothetical membrane spanning protein638720886 8.73 9.52 1.56 down 9.07E-‐04 RRSL_02373 o c CAIB/BAIF family protein638720888 11.15 10.57 1.65 up 2.02E-‐01 RRSL_02376 Zinc metalloprotease( EC:3.4.24.-‐ )638720889 10.54 10.21 1.38 up 1.68E-‐01 RRSL_02377 o Hypothetical cytosolic protein638720890 12.66 12.37 1.35 up 3.41E-‐01 RRSL_02378 Hypothetical Protein

638720893 7.94 8.33 1.19 down 4.71E-‐01 RRSL_02381 o c Ferrichrome receptor fcuA precursor638720894 7.89 8.12 1.06 down 7.29E-‐01 RRSL_02382 o c Hypothetical Protein638720895 8.7 8.41 1.35 up 9.82E-‐02 RRSL_02383 o c stomatin like protein638720896 9.45 8.61 1.97 up 2.01E-‐03 RRSL_02384 o c nfeD NfeD638720898 9.4 8.96 1.49 up 3.87E-‐02 RRSL_02386 o c Transporter, MFS superfamily638720899 8.34 8.86 1.3 down 1.06E-‐01 RRSL_02387 o c Class II Aldolase and Adducin proteins638720900 10.93 11.74 1.59 down 4.95E-‐03 RRSL_02388 o c low-‐specificity threonine aldolase( EC:4.1.2.5 )638720901 8.43 9.15 1.49 down 6.95E-‐02 RRSL_02389 o c Phosphohydrolase (MutT/nudix family protein)638720902 7.62 8.27 1.42 down 2.00E-‐01 RRSL_02390 o c Hypothetical Protein638720903 10.74 11.69 1.76 down 4.76E-‐02 RRSL_02391 o c Cytochrome c638720904 9.45 10.3 1.64 down 5.71E-‐02 RRSL_02392 o c Oxidoreductase sulfite:cytrochrome C oxidoreductase subunit A (sorAa)638720905 9.81 10.58 1.55 down 1.29E-‐01 RRSL_02393 o c Transmembrane threonine efflux protein638720906 7.93 7.82 1.19 up 3.03E-‐01 RRSL_02394 Universal stress protein family638720908 8.92 9.22 1.12 down 7.57E-‐01 RRSL_02396 o c Hypothetical Protein638720909 12.32 13.27 1.75 down 3.94E-‐02 RRSL_02397 o c Glutathione S-‐transferase( EC:2.5.1.18 )638720910 12.85 13.18 1.14 down 5.06E-‐01 RRSL_02398 o c Hypothetical Protein638720911 8.3 9.12 1.6 down 2.25E-‐02 RRSL_02399 Shikimate kinase( EC:2.7.1.71 )638720912 7.91 7.78 1.21 up 2.91E-‐01 RRSL_02400 Hypothetical Protein638720913 7.63 7.74 1.02 up 9.29E-‐01 RRSL_02401 Hypothetical Protein638720914 7.57 8.1 1.31 down 1.54E-‐01 RRSL_02402 Mu-‐like prophage FluMu protein gp29638720915 8.9 9.13 1.07 down 7.73E-‐01 RRSL_02403 o Phage protein638720916 7.12 7.29 1.02 down 8.69E-‐01 RRSL_02404 Hypothetical Protein638720917 6.65 7.74 1.93 down 4.99E-‐02 RRSL_02405 Hypothetical Protein638720918 10.31 10.42 1.02 up 9.39E-‐01 RRSL_02406 Hypothetical Protein638720919 8.07 8.38 1.12 down 6.70E-‐01 RRSL_02408 o Phage protein638720920 13.65 14.07 1.21 down 7.48E-‐02 RRSL_02409 Hypothetical Protein638720921 9.27 9.94 1.43 down 1.80E-‐01 RRSL_02410 conserved hypothetical protein638720922 7.26 7.48 1.05 down 7.77E-‐01 RRSL_02411 hypothetical protein638720923 8.43 8.76 1.14 down 5.49E-‐01 RRSL_02412 o Transposase638720924 7.65 8.46 1.6 down 8.23E-‐02 RRSL_02413 DNA transposition protein638720925 9.1 9.63 1.3 down 4.51E-‐01 RRSL_02415 Hypothetical Protein638720926 8.89 9.42 1.3 down 5.73E-‐02 RRSL_02414 Conserved hypothetical protein638720927 9.16 9.68 1.3 down 7.15E-‐02 RRSL_02416 Conserved hypothetical protein638720929 7.32 7.56 1.07 down 7.00E-‐01 RRSL_02418 Conserved hypothetical protein638720932 7.7 8.28 1.35 down 1.64E-‐01 RRSL_02422 o Possible Mu-‐like prophage FluMu I protein638720933 7.41 7.94 1.31 down 2.07E-‐02 RRSL_02423 o Possible Mu-‐like prophage FluMu major head subunit638720934 9.48 9.95 1.26 down 2.43E-‐01 RRSL_02424 Hypothetical protein638720935 7.01 7.64 1.4 down 2.58E-‐02 RRSL_02425 Conserved hypothetical protein638720936 7.57 8.22 1.42 down 2.01E-‐01 RRSL_02426 Hypothetical Protein638720937 8.46 9.19 1.51 down 2.14E-‐02 RRSL_02427 gpl Gpl638720938 7.18 7.65 1.25 down 2.34E-‐01 RRSL_02428 Conserved hypothetical protein638720939 7.32 7.84 1.3 down 2.97E-‐02 RRSL_02429 probable gene 66 protein638720940 6.71 7.61 1.7 down 4.28E-‐02 RRSL_02430 Hypothetical protein638720941 9.01 8.52 1.54 up 2.98E-‐01 RRSL_02431 Conserved hypothetical protein638720942 7.65 7.86 1.05 down 8.55E-‐01 RRSL_02432 o Putative phage FluMu DNA circulation protein638720943 8.39 8.16 1.3 up 2.52E-‐01 RRSL_02433 o putative bacteriophage tail protein (gpP)638720944 12.24 12 1.3 up 1.47E-‐01 RRSL_02434 o phage baseplate assembly protein V subfamily638720945 7.59 8.22 1.4 down 3.92E-‐02 RRSL_02435 Hypothetical Protein638720946 8.02 8.83 1.58 down 5.38E-‐02 RRSL_02436 o Putative bacteriophage protein638720947 11.01 11.25 1.07 down 5.86E-‐01 RRSL_02437 Hypothetical protein638720948 7.64 8.44 1.57 down 1.05E-‐01 RRSL_02438 Hypothetical protein638720950 10.23 10.1 1.21 up 7.31E-‐02 RRSL_02440 Hypothetical Protein638720951 10.07 10.44 1.17 down 4.21E-‐01 RRSL_RNA022 ( tRNA )638720952 8.8 9.51 1.48 down 7.08E-‐02 RRSL_02170 o c Phosphohistidine phosphatase sixA( EC:3.1.3.-‐ )638720953 8.58 8.39 1.26 up 7.17E-‐02 RRSL_02171 o c Hypothetical Protein638720954 11.39 12.27 1.67 down 1.10E-‐01 RRSL_02172 o c Exopolyphosphatase( EC:3.6.1.11 )638720956 9.25 9.45 1.04 down 8.19E-‐01 RRSL_02174 o c Phosphate regulon sensor protein phoR( EC:2.7.3.-‐ )638720957 10.83 10.6 1.29 up 2.44E-‐01 RRSL_02175 o c phoB PhoB638720958 9.93 10.09 1.01 down 9.70E-‐01 RRSL_02176 o c phoU PhoU638720959 9.73 9.63 1.18 up 5.71E-‐01 RRSL_02177 o c pstB PstB( EC:3.6.3.27 )638720962 10.93 10.41 1.58 up 3.54E-‐01 RRSL_02180 o c Phosphate-‐binding protein638720963 10.97 11.96 1.8 down 3.74E-‐02 RRSL_02181 o c Phosphoglucosamine mutase( EC:5.4.2.10 )638720964 12.07 11.88 1.25 up 1.68E-‐01 RRSL_02182 o c Dihydropteroate synthase( EC:2.5.1.15 )638720965 12.26 12.95 1.46 down 1.88E-‐01 RRSL_02183 o c Cell division protein ftsH( EC:3.4.24.-‐ )638720966 11.69 12.47 1.55 down 3.44E-‐02 RRSL_02185 o c 23S rRNA Um2552 2'-‐O-‐methyltransferase( EC:2.1.1.-‐ )638720972 12.63 13.77 1.99 down 2.09E-‐02 RRSL_02190 o c Carbamoyl-‐phosphate synthase small chain( EC:6.3.5.5 )638720973 9.46 9.19 1.33 up 6.09E-‐02 RRSL_02191 o Propionate-‐-‐CoA ligase( EC:6.2.1.17 )638720974 11.07 11.79 1.49 down 3.36E-‐03 RRSL_02192 o c Membrane-‐bound lytic murein transglycosylase D precursor( EC:3.2.1.-‐ )638720975 11.51 11.96 1.24 down 1.48E-‐01 RRSL_02194 o c Hydroxyacylglutathione hydrolase( EC:3.1.2.6 )638720976 11.06 11.71 1.42 down 3.40E-‐03 RRSL_02193 o c Methyltransferase( EC:2.1.1.-‐ )638720977 11.56 11.27 1.35 up 1.79E-‐02 RRSL_02196 o c Hypothetical Protein638720987 7.11 7.51 1.2 down 2.98E-‐01 RRSL_02206 Hypothetical Protein638720988 7.32 7.31 1.11 up 8.17E-‐01 RRSL_02207 Hypothetical Protein638720989 9.08 8.89 1.26 up 2.45E-‐01 RRSL_02209 Hypothetical Protein638720990 10.33 11.26 1.74 down 1.73E-‐01 RRSL_02208 Hypothetical Protein638720992 10.53 11.17 1.41 down 9.78E-‐02 RRSL_02211 Hypothetical Protein

638720993 7.88 8.7 1.6 down 4.92E-‐02 RRSL_02212 o Alpha,alpha-‐trehalose-‐phosphate synthase (UDP-‐forming)( EC:2.4.1.15 )638720994 8.2 8.21 1.1 up 5.97E-‐01 RRSL_02213 o Hypothetical Protein638720995 10.87 11.12 1.08 down 5.41E-‐01 RRSL_02214 o C-‐5 sterol desaturase( EC:1.3.-‐ )638720997 9.3 8.73 1.65 up 1.03E-‐01 RRSL_02217 o Hypothetical Protein638720998 8.85 8.54 1.36 up 1.84E-‐01 RRSL_02218 Hypothetical Protein638720999 8.97 9.25 1.1 down 4.79E-‐01 RRSL_02219 o putative dinucleotide-‐utilizing enzyme638721000 9.21 10.01 1.58 down 8.28E-‐02 RRSL_02220 o Hypothetical Protein638721001 7.2 7.01 1.25 up 5.75E-‐02 RRSL_02221 Hypothetical Protein638721002 8.52 8.78 1.08 down 6.63E-‐01 RRSL_02222 o Hypothetical Protein638721003 9.21 9.22 1.09 up 7.38E-‐01 RRSL_02223 o Hypothetical Protein638721004 7.17 7.21 1.07 up 6.35E-‐01 RRSL_02224 o Methylamine utilization protein mauG precursor638721005 11.57 12.89 2.26 down 5.52E-‐02 RRSL_02225 o Hypothetical Protein638721009 8.5 8.28 1.29 up 3.91E-‐02 RRSL_02229 o Hypothetical Protein638721010 9.3 10.34 1.86 down 3.21E-‐02 RRSL_02230 o Sensor protein glpS( EC:2.7.3.-‐ )638721012 9.63 10.04 1.21 down 1.32E-‐01 RRSL_02232 o c Hypothetical Protein638721013 10.16 11.11 1.75 down 2.25E-‐03 RRSL_02233 o livF LivF638721014 9.07 9.96 1.68 down 5.83E-‐02 RRSL_02234 o livG LivG638721015 10.88 11.66 1.55 down 1.14E-‐01 RRSL_02235 o livH LivH638721016 7.29 7.36 1.05 up 8.30E-‐01 RRSL_03128 o L-‐idonate 5-‐dehydrogenase( EC:1.1.1.264 )638721017 7.48 7.56 1.04 up 8.43E-‐01 RRSL_03127 o NAD(P) transhydrogenase alpha subunit( EC:1.6.1.2 )638721018 10.27 8.79 3.07 up 5.77E-‐02 RRSL_03126 o NAD(P) transhydrogenase alpha subunit( EC:1.6.1.2 )638721019 8.4 7.88 1.58 up 9.96E-‐02 RRSL_03125 NAD(P) transhydrogenase subunit beta( EC:1.6.1.2 )638721020 9.11 9.17 1.06 up 7.79E-‐01 RRSL_03123 o Outer membrane porin protein 32 precursor638721021 11.02 11.76 1.51 down 8.78E-‐02 RRSL_03122 Hypothetical Protein638721022 10.21 11.57 2.33 down 6.53E-‐02 RRSL_03121 Hypothetical Protein638721023 8.94 8.56 1.44 up 8.04E-‐02 RRSL_03120 Hypothetical Protein638721024 10.5 10.08 1.48 up 2.42E-‐02 RRSL_03119 Hypothetical Protein638721025 8.2 8.59 1.19 down 4.04E-‐01 RRSL_03118 o Transcriptional regulator, MerR family638721027 9.07 8.29 1.9 up 6.11E-‐02 RRSL_03116 o L-‐threonine 3-‐dehydrogenase( EC:1.1.1.103 )638721030 8.3 9.32 1.83 down 1.11E-‐02 RRSL_03112 ftsK FtsK638721031 12.35 12.22 1.21 up 5.70E-‐01 RRSL_03111 Hypothetical Protein638721032 8.83 8.1 1.83 up 8.38E-‐02 RRSL_03110 o Hypothetical Protein638721033 8.96 8.51 1.51 up 6.70E-‐02 RRSL_03109 o Hypothetical Protein638721034 9.33 9.07 1.33 up 9.53E-‐02 RRSL_03108 o probable transmembrane glycosyl hydrolase638721037 9.05 9.61 1.34 down 1.15E-‐01 RRSL_03104 o c prhA PrhA638721038 7.54 7.63 1.03 up 8.92E-‐01 RRSL_03103 o Transcriptional regulatory protein638721039 8.52 8.36 1.23 up 3.25E-‐01 RRSL_03102 o hypothetical protein rs03064638721040 10.36 9.55 1.93 up 2.32E-‐02 RRSL_03101 Lactoylglutathione lyase638721041 7.77 7.62 1.22 up 2.28E-‐01 RRSL_03100 transcriptional regulator, LysR family638721043 8.29 8.38 1.03 up 7.99E-‐01 RRSL_02447 conserved hypothetical protein638721044 9.26 9.9 1.41 down 1.61E-‐01 RRSL_02445 Conserved hypothetical protein638721045 8.77 8.53 1.3 up 3.18E-‐01 RRSL_02444 Hypothetical Protein638721072 9.21 9.32 1.03 up 8.28E-‐01 RRSL_00503 o prhR PrhR638721074 8.15 8.14 1.11 up 6.04E-‐01 RRSL_00500 Hypothetical Protein638721075 9.65 8.58 2.32 up 1.79E-‐01 RRSL_03129 o Gluconate 5-‐dehydrogenase( EC:1.1.1.69 )638721076 6.98 7.34 1.17 down 4.23E-‐01 RRSL_03130 o Gluconokinase( EC:2.7.1.12 )638721077 9.57 9.28 1.35 up 6.16E-‐02 RRSL_03131 o 2-‐hydroxyacid dehydrogenase( EC:1.1.1.-‐ )638721078 9.23 8.91 1.38 up 1.91E-‐01 RRSL_03132 o Demethylmenaquinone methyltransferase family638721079 9.39 8.75 1.72 up 1.49E-‐01 RRSL_03133 o Aspartate aminotransferase( EC:2.6.1.1 )638721082 7.05 7.89 1.63 down 2.96E-‐02 RRSL_03136 o Biotin carboxylase( EC:6.3.4.14 )638721083 7.44 7.95 1.3 down 1.98E-‐01 RRSL_03138 o Regulator of kinase autophosphorylation inhibitor638721084 7.6 8.12 1.3 down 1.53E-‐01 RRSL_03139 o Hypothetical Protein638721085 7.98 8.94 1.75 down 7.57E-‐03 RRSL_03140 o Lactam utilization protein LAMB638721086 10.42 10.8 1.18 down 5.18E-‐01 RRSL_03141 o Short chain dehydrogenase638721087 7.24 7.44 1.04 down 8.76E-‐01 RRSL_03142 o Hypothetical Protein638721088 8.6 8.75 1.01 down 9.76E-‐01 RRSL_03143 o Hypothetical Protein638721089 9.68 10.5 1.6 down 1.91E-‐02 RRSL_03144 o glnQ GlnQ638721090 10.98 11.66 1.45 down 1.09E-‐02 RRSL_03145 o ABC transporter amino acid-‐binding protein638721091 8.01 8.76 1.53 down 1.25E-‐02 RRSL_03146 o Hypothetical Protein638721092 8.45 8.94 1.27 down 2.64E-‐01 RRSL_03147 o Formate acetyltransferase( EC:2.3.1.54 )638721095 13.91 13.49 1.48 up 2.49E-‐01 RRSL_03151 o c hpiS HpiS638721098 15.71 16.67 1.77 down 1.57E-‐03 RRSL_03154 o c Outer membrane porin protein 32 precursor638721099 11.13 10.36 1.88 up 4.34E-‐02 RRSL_03155 o c Hypothetical Protein638721100 9.09 9.82 1.5 down 2.45E-‐01 RRSL_03156 o c Carboxypeptidase G2 precursor( EC:3.4.17.11 )638721103 11.02 10.64 1.44 up 5.93E-‐03 RRSL_03161 o c Probable hemagglutinin-‐related protein638721104 7.85 8.03 1.02 down 9.27E-‐01 RRSL_03162 o putative hemolysin activating-‐like protein638721105 8.91 8.33 1.65 up 1.32E-‐01 RRSL_03164 o Hemolysin activator protein precursor638721106 11.29 10.7 1.66 up 1.61E-‐01 RRSL_03165 Hypothetical Protein638721107 9.27 8.51 1.87 up 8.90E-‐02 RRSL_03166 JemB638721109 10.97 11.33 1.17 down 3.32E-‐01 RRSL_03168 o c Hypothetical Protein638721111 10.14 10.02 1.2 up 4.69E-‐01 RRSL_03170 o c Transcriptional regulatory protein638721112 9.61 9.95 1.15 down 3.31E-‐01 RRSL_03171 o c transmembrane protein, hypothetical638721113 9.5 9.99 1.27 down 3.19E-‐01 RRSL_03172 o c TRANSMEMBRANE LIPOPROTEIN, tadD2638721114 10.74 10.82 1.05 up 7.08E-‐01 RRSL_03173 o c TRANSMEMBRANE TIGHT ADHERENCE TADC RELATED PROTEIN; tadC2638721115 9.64 9.99 1.16 down 4.31E-‐01 RRSL_03174 o c TRANSMEMBRANE PILUS ASSEMBLY PROTEIN: TadB2638721116 11.6 11.75 1.01 down 9.49E-‐01 RRSL_03175 o c Secretion ATPase; CpaF2

638721117 10.83 11.24 1.2 down 3.95E-‐01 RRSL_03176 o c PUTATIVE PILUS ASSEMBLY PROTEIN: CpaE2638721118 11.73 11.8 1.05 up 7.93E-‐01 RRSL_03177 o c GspD-‐related protein; CpaC2638721119 10.55 11.34 1.57 down 1.34E-‐01 RRSL_03178 o c SIGNAL PEPTIDE HYPOTHETICAL; CpaB2638721120 12.34 12.88 1.32 down 2.52E-‐01 RRSL_03179 o c TRANSMEMBRANE HYPOTHETICAL; TadG2638721121 16 15.53 1.53 up 5.08E-‐03 RRSL_03180 o c PROBABLE PREPILIN PEPTIDASE TRANSMEMBRANE PROTEIN; CpaA2638721122 15.86 15.09 1.87 up 1.88E-‐04 RRSL_03181 o c putative pilin protein638721123 8.65 8.91 1.09 down 5.36E-‐01 RRSL_03182 o c putative hemagglutinin-‐related transmembrane protein638721125 11.78 11.91 1.01 up 9.82E-‐01 RRSL_03185 o c heme:hemopexin-‐binding protein638721126 13.25 13.21 1.13 up 4.65E-‐01 RRSL_03186 o c putative transcription regulator protein638721127 16.24 16.3 1.06 up 6.28E-‐01 RRSL_03187 o Transposase638721128 9.05 9.09 1.07 up 6.97E-‐01 RRSL_02107 o Porin638721134 9.01 10.08 1.9 down 5.46E-‐02 RRSL_02114 o c morphinone reductase( EC:1.3.1.-‐ )638721135 11.97 11.36 1.68 up 2.17E-‐01 RRSL_02115 o c Quinone oxidoreductase( EC:1.6.5.5 )638721136 11.92 12.58 1.44 down 6.75E-‐02 RRSL_02116 o c Acid phosphatase surE( EC:3.1.3.2 )638721137 11.62 12.13 1.29 down 1.51E-‐01 RRSL_02117 o c Protein-‐L-‐isoaspartate O-‐methyltransferase( EC:2.1.1.77 )638721138 13.72 14.12 1.2 down 3.27E-‐01 RRSL_02118 o c nlpD NlpD638721139 11.81 12.25 1.23 down 4.99E-‐01 RRSL_02119 o c rpoS RpoS638721140 10.51 10.99 1.27 down 2.45E-‐01 RRSL_02121 o c dioxygenase( EC:1.13.11.-‐ )638721141 9.81 10.4 1.37 down 6.92E-‐02 RRSL_02120 o c 23S rRNA m(5)U 1939 methyltransferase( EC:2.1.1.-‐ )638721143 15.37 15.84 1.26 down 4.57E-‐02 RRSL_02123 o c Nucleoside diphosphate kinase( EC:2.7.4.6 )638721144 10.75 11.85 1.94 down 1.12E-‐01 RRSL_02124 o c Radical SAM family enzyme638721145 12.16 12.52 1.16 down 4.51E-‐01 RRSL_02125 o c PilF protein638721146 10.35 11.17 1.6 down 9.54E-‐02 RRSL_02126 o c Transcriptional regulator638721147 11 11.76 1.53 down 2.11E-‐01 RRSL_02127 o c 1-‐hydroxy-‐2-‐methyl-‐2-‐(E)-‐butenyl 4-‐diphosphate synthase638721148 10.33 11.46 1.99 down 1.29E-‐02 RRSL_02128 o c Histidyl-‐tRNA synthetase( EC:6.1.1.21 )638721149 12.67 13.33 1.43 down 1.08E-‐01 RRSL_02129 o c Hypothetical Protein638721150 11.02 12.13 1.95 down 6.82E-‐02 RRSL_02130 o c quinoprotein dehydrogenase638721151 9.5 10.41 1.71 down 5.25E-‐02 RRSL_02131 o c GTP-‐binding protein638721152 16.31 16.09 1.28 up 2.24E-‐03 RRSL_02132 o c Hypothetical Protein638721153 12.51 13.3 1.56 down 1.20E-‐01 RRSL_02133 o c hflX HflX638721155 11.91 12.77 1.65 down 4.18E-‐02 RRSL_02135 o c Protease activity modulator HflC638721156 10.65 11.01 1.17 down 1.84E-‐01 RRSL_02136 o c Hypothetical Protein638721158 13.35 13.69 1.15 down 3.72E-‐01 RRSL_02138 o c Adenylosuccinate synthetase( EC:6.3.4.4 )638721159 13.37 13.66 1.11 down 4.15E-‐01 RRSL_02139 o c Xanthine-‐guanine phosphoribosyltransferase( EC:2.4.2.22 )638721161 12.66 12.43 1.3 up 1.74E-‐01 RRSL_02140 o c Ribonuclease R( EC:3.1.-‐ )638721162 10.07 11.03 1.77 down 7.60E-‐02 RRSL_02141 o c 23S rRNA Gm2251 methyltransferase( EC:2.1.1.-‐ )638721163 9.88 10.8 1.71 down 7.74E-‐02 RRSL_02142 o c SIR2 family protein638721164 11.92 12.74 1.6 down 6.39E-‐02 RRSL_02143 o c Transaldolase( EC:2.2.1.2 )638721166 11.68 10.68 2.2 up 1.77E-‐01 RRSL_02145 o c Cytosine/uracil/thiamine/allantoin permease family protein638721167 8.08 7.32 1.87 up 7.74E-‐02 RRSL_02147 o c Probable transmembrane methyl-‐accepting chemotaxis protein638721168 12.05 12.79 1.52 down 5.54E-‐02 RRSL_02148 o c yggX YggX638721169 9.59 9.31 1.34 up 4.05E-‐01 RRSL_02149 Hypothetical protein638721170 11.07 10.55 1.58 up 1.03E-‐01 RRSL_02150 o Transcriptional regulator, RpiR family638721171 10.45 10.03 1.48 up 3.13E-‐01 RRSL_02151 Hypothetical Protein638721174 10.81 10.69 1.2 up 3.90E-‐01 RRSL_02154 Hypothetical protein638721175 12.39 12.21 1.25 up 8.35E-‐02 RRSL_02155 Hypothetical cytosolic protein638721176 8.26 7.58 1.77 up 2.14E-‐03 RRSL_02156 Rieske-‐type ferredoxin638721177 10.37 9.88 1.55 up 2.95E-‐02 RRSL_02157 Hypothetical protein638721178 7.99 7.74 1.31 up 2.42E-‐01 RRSL_02158 Hypothetical protein638721182 10.21 9.43 1.9 up 1.70E-‐01 RRSL_02162 o 5-‐dehydro-‐2-‐deoxygluconokinase( EC:2.7.1.92 )638721187 9.14 8.61 1.58 up 2.37E-‐01 RRSL_02167 Hypothetical protein638721188 10.53 10.82 1.1 down 6.59E-‐01 RRSL_02168 o c Amino-‐acid acetyltransferase( EC:2.3.1.1 )638721189 10.9 10.33 1.64 up 1.34E-‐02 RRSL_02514 o hypothetical protein638721191 10.3 9.54 1.87 up 2.42E-‐02 RRSL_02515 hypothetical protein638721192 9.67 7.16 6.31 up 6.12E-‐02 RRSL_02517 hypothetical protein638721194 9.84 10.23 1.19 down 6.24E-‐01 RRSL_02519 o c probable transmembrane638721195 8.37 8.7 1.14 down 4.28E-‐01 RRSL_02520 o c Probable outer membrane drug efflux lipoprotein638721196 7.38 7.34 1.13 up 5.34E-‐01 RRSL_02521 o c Acriflavin resistance periplasmic protein638721197 7.79 7.63 1.23 up 4.37E-‐01 RRSL_02522 o c transmembrane transport protein638721198 7.64 7.16 1.54 up 6.90E-‐02 RRSL_02523 o Aromatic compound transporter, MFS family638721199 8.24 7.81 1.48 up 1.12E-‐01 RRSL_02525 o Outer membrane porin protein 32 precursor638721200 9.23 9.17 1.15 up 6.20E-‐02 RRSL_02526 o c Transcriptional regulators, LysR family638721201 10.05 10.48 1.21 down 2.45E-‐01 RRSL_02527 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638721202 9.23 9.69 1.25 down 3.99E-‐02 RRSL_02528 o c piperideine-‐6-‐carboxylate dehydrogenase( EC:1.2.1.-‐ )638721203 8.6 8.71 1.03 up 8.75E-‐01 RRSL_02529 o c Oxidoreductase( EC:1.1.1.-‐ )638721204 11.61 12.09 1.27 down 3.29E-‐01 RRSL_02531 o c O-‐acetylhomoserine sulfhydrylase / O-‐acetylserine sulfhydrylase( EC:4.2.99.10,EC:4.2.99.8 )638721206 11.68 12.77 1.93 down 2.97E-‐02 RRSL_02534 o c hypothetical protein638721208 11.88 12.92 1.87 down 1.04E-‐02 RRSL_02536 o c hypothetical protein638721209 14.15 14.77 1.38 down 2.49E-‐02 RRSL_02537 o c Agmatinase( EC:3.5.3.11 )638721210 11.1 12.02 1.71 down 3.19E-‐02 RRSL_02538 o c asparagine transport system permease protein638721211 11.37 11.74 1.17 down 1.51E-‐01 RRSL_02539 o c Transporter638721212 11.71 12.33 1.4 down 7.23E-‐03 RRSL_02540 o c ABC Transporter Amino Acid binding protein638721214 7.79 8.42 1.41 down 2.90E-‐02 RRSL_02542 o c Translation initiation inhibitor638721215 11.08 10.74 1.4 up 3.07E-‐01 RRSL_02543 o c Transporter638721217 8.42 8.19 1.29 up 6.89E-‐02 RRSL_02546 hypothetical protein638721219 7.51 8.14 1.4 down 4.04E-‐02 RRSL_02548 ferric siderophore receptor

638721221 12.28 11.67 1.68 up 1.77E-‐02 RRSL_02550 hypothetical protein638721222 8.19 8.26 1.05 up 7.90E-‐01 RRSL_02552 o c hypothetical protein638721223 8.94 8.77 1.24 up 3.37E-‐01 RRSL_02553 o c hypothetical protein638721224 8.57 8.35 1.29 up 1.10E-‐01 RRSL_02554 o c Serine protease( EC:3.4.21.-‐ )638721225 7.05 7.64 1.36 down 1.98E-‐02 RRSL_02555 o c rtcR RtcR638721226 10.18 9.14 2.26 up 1.64E-‐01 RRSL_02556 o c hypothetical protein638721227 9.38 9.91 1.31 down 2.00E-‐01 RRSL_02557 o c hypothetical protein638721228 8.96 9.77 1.58 down 1.61E-‐01 RRSL_02558 o c Hypothetical cytosolic protein638721229 7.1 7.44 1.15 down 3.23E-‐01 RRSL_02559 o c RNA 3'-‐terminal phosphate cyclase( EC:6.5.1.4 )638721230 10.78 11.11 1.14 down 6.59E-‐01 RRSL_02560 Conserved hypothetical protein638721231 10 11.03 1.85 down 2.24E-‐03 RRSL_02561 o c Transcriptional regulatory protein638721232 9.47 9.31 1.23 up 3.96E-‐01 RRSL_02562 chrA ChrA638721233 8.49 8.37 1.2 up 8.56E-‐02 RRSL_02563 o c Low temperature requirement protein A638721234 10.47 9.71 1.87 up 7.34E-‐02 RRSL_02564 o c Transmembrane (Homoserine/ Homoserine Lactone) Efflux protein638721235 8.64 7.8 1.97 up 2.65E-‐02 RRSL_02565 o transmembrane integral membrane protein638721236 7.52 8.08 1.34 down 4.30E-‐02 RRSL_02566 o Transcriptional regulator, AraC family638721237 8.45 8 1.5 up 2.42E-‐01 RRSL_02567 hypothetical protein638721238 10.38 10.07 1.36 up 1.92E-‐01 RRSL_02568 o c hypothetical protein638721239 9 10.05 1.88 down 3.20E-‐02 RRSL_02569 o c hypothetical protein638721240 9.28 9.01 1.33 up 2.29E-‐02 RRSL_02570 o c Methylmalonyl-‐CoA mutase coenzyme B12-‐binding subunit / LAO/AO transport system kinase / Methylmalonyl-‐CoA mutase alpha subunit( EC:2.7.-‐,EC:5.4.99.2 )638721242 9.59 9.21 1.44 up 2.64E-‐01 RRSL_02573 o c hypothetical protein638721243 9.52 10.28 1.54 down 3.11E-‐02 RRSL_02449 o Urease gamma subunit( EC:3.5.1.5 )638721244 9.41 10.41 1.82 down 2.18E-‐02 RRSL_02450 o High-‐affinity nickel transport protein638721250 14.49 13.92 1.63 up 5.92E-‐03 RRSL_02456 o Hypothetical Protein638721251 15.39 14.71 1.76 up 1.21E-‐02 RRSL_02457 Hypothetical Protein638721253 12.61 12.61 1.1 up 7.10E-‐01 RRSL_02459 Hypothetical Protein638721254 11.47 11.27 1.27 up 7.77E-‐02 RRSL_02460 o Hypothetical protein638721255 13.59 13.98 1.19 down 1.67E-‐01 RRSL_02461 o Glutathione S-‐transferase( EC:2.5.1.18 )638721256 8.47 8.64 1.02 down 8.87E-‐01 RRSL_02462 o c Acyl-‐CoA dehydrogenase( EC:1.3.99.-‐ )638721257 10.28 9.16 2.39 up 7.01E-‐02 RRSL_02464 o paaI PaaI638721258 7.35 8.22 1.66 down 4.40E-‐02 RRSL_02463 o c Transcriptional regulators, LysR family638721259 7.51 8.04 1.31 down 1.81E-‐01 RRSL_02465 Transcriptional regulators, LysR family638721260 8.66 8.14 1.58 up 6.09E-‐02 RRSL_02466 o Hypothetical Protein638721261 9.52 9.35 1.24 up 3.44E-‐01 RRSL_02467 o Phosphotransferase638721262 8.42 8.69 1.1 down 5.32E-‐01 RRSL_02468 o Phosphoglycerate mutase( EC:5.4.2.1 )638721263 9.38 9.75 1.17 down 1.21E-‐01 RRSL_02469 o Enoyl-‐CoA hydratase( EC:4.2.1.17 )638721264 8.66 8.87 1.05 down 8.03E-‐01 RRSL_02470 o 3-‐hydroxybutyryl-‐CoA dehydrogenase( EC:1.1.1.157 )638721265 9.92 10.16 1.07 down 6.89E-‐01 RRSL_02471 o c Glutathione-‐S-‐transferases638721266 9.77 10.51 1.51 down 6.52E-‐03 RRSL_02472 o c Aspartate aminotransferase( EC:2.6.1.1 )638721267 12.02 10.32 3.59 up 8.61E-‐02 RRSL_02473 o c yaaA YaaA638721268 9.47 10.43 1.77 down 5.09E-‐03 RRSL_02475 o c Zinc-‐carboxypeptidase precursor( EC:3.4.17.-‐ )638721269 10.96 12.04 1.91 down 1.26E-‐02 RRSL_02476 o c probable transmembrane lipoprotein638721273 9.98 11.01 1.85 down 5.64E-‐02 RRSL_02481 o c 2-‐methylcitrate dehydratase / 2-‐methylisocitrate dehydratase( EC:4.2.1.79,EC:4.2.1.99 )638721275 10.98 11.65 1.44 down 4.00E-‐02 RRSL_02483 2-‐methylcitrate synthase( EC:2.3.3.5,EC:4.1.3.31 )638721276 8.62 9.4 1.56 down 8.65E-‐02 RRSL_02484 o c Methylisocitrate lyase( EC:4.1.3.30 )638721277 10.21 10.53 1.13 down 4.67E-‐01 RRSL_02485 o c Malate-‐-‐CoA ligase alpha chain( EC:6.2.1.9 )638721278 13.72 14.74 1.84 down 4.02E-‐02 RRSL_02486 o c Malate dehydrogenase( EC:1.1.1.37,EC:1.1.1.82 )638721279 9.31 9.77 1.25 down 2.39E-‐01 RRSL_02487 o c Transcriptional regulator, GntR family638721280 15.77 16.16 1.19 down 2.89E-‐02 RRSL_02488 o c Hypothetical Protein638721281 14.15 14.85 1.48 down 8.58E-‐02 RRSL_02489 o c Succinate dehydrogenase membrane anchor subunit( EC:1.3.99.1 )638721285 13.47 14.45 1.78 down 3.80E-‐02 RRSL_02493 o c Citrate synthase( EC:2.3.3.1,EC:4.1.3.7 )638721286 9.85 10.92 1.89 down 4.68E-‐02 RRSL_02494 o c leuC LeuC( EC:4.2.1.33 )638721287 12.33 12.94 1.38 down 6.24E-‐02 RRSL_02495 o c 3-‐isopropylmalate dehydratase small subunit( EC:4.2.1.33 )638721288 10.92 11.79 1.65 down 5.70E-‐02 RRSL_02496 o c 3-‐isopropylmalate dehydrogenase( EC:1.1.1.85 )638721291 10.5 10.83 1.14 down 2.04E-‐01 RRSL_02500 o c tRNA pseudouridine synthase A( EC:4.2.1.70 )638721292 10.87 11.32 1.23 down 1.05E-‐01 RRSL_02501 o c N-‐(5'-‐phosphoribosyl)anthranilate isomerase( EC:5.3.1.24 )638721293 11.52 12.09 1.35 down 1.37E-‐02 RRSL_02502 o c Tryptophan synthase beta chain( EC:4.2.1.20 )638721294 11.84 12.39 1.33 down 1.85E-‐02 RRSL_02504 o c Tryptophan synthase alpha chain( EC:4.2.1.20 )638721295 13.43 14.24 1.58 down 2.97E-‐02 RRSL_02505 o c Acetyl-‐coenzyme A carboxylase carboxyl transferase subunit beta( EC:6.4.1.2 )638721296 10.58 11.1 1.3 down 8.93E-‐02 RRSL_02506 o c folylpolyglutamate synthase / dihydrofolate synthase( EC:6.3.2.12,EC:6.3.2.17 )638721297 9.87 10.96 1.92 down 1.55E-‐02 RRSL_02507 o c probable transmembrane protein638721298 12.62 12.67 1.06 up 4.42E-‐01 RRSL_02508 o c Colicin V production protein638721300 10.98 11.08 1.03 up 8.04E-‐01 RRSL_02510 o c ABC transporter transmembrane permease protein638721301 10.14 10.8 1.43 down 1.23E-‐02 RRSL_02511 o c Putative bacteriocin export ATP-‐binding protein638721302 11.1 11.68 1.36 down 1.86E-‐01 RRSL_02512 Putative osmotically inducible lipoprotein B1 transmemberane-‐related protein638721303 10.81 11.11 1.12 down 3.66E-‐01 RRSL_01731 o Hypothetical protein638721304 10.37 11.44 1.9 down 1.51E-‐01 RRSL_01732 o Hypothetical Protein638721305 13.51 13.8 1.11 down 6.97E-‐01 RRSL_01733 o Hypothetical cytosolic protein638721306 11.69 12.19 1.28 down 4.22E-‐01 RRSL_01734 o Hypothetical cytosolic protein638721307 15.63 15.6 1.13 up 3.44E-‐01 RRSL_01735 o Hypothetical Protein638721308 10.15 10.85 1.48 down 2.99E-‐01 RRSL_01736 o Hypothetical protein638721309 9.88 10.61 1.5 down 1.04E-‐01 RRSL_01737 o Hypothetical protein638721310 8.08 8.77 1.47 down 1.69E-‐01 RRSL_01738 o quinoprotein dehydrogenase638721311 9.57 10.41 1.62 down 8.98E-‐02 RRSL_01739 o ClpB protein638721312 9.7 10.33 1.41 down 3.79E-‐03 RRSL_01740 o VgrG protein638721313 9.85 10.25 1.2 down 3.48E-‐01 RRSL_01741 o Hypothetical Protein

638721314 11.92 11.85 1.16 up 1.73E-‐01 RRSL_01742 Hypothetical Protein638721315 11.33 11.86 1.31 down 9.06E-‐03 RRSL_01743 Hypothetical Protein638721316 10.78 11.34 1.33 down 5.94E-‐02 RRSL_01744 Hypothetical Protein638721318 9.82 9.91 1.03 up 8.91E-‐01 RRSL_01746 Hypothetical Protein638721319 7.64 8.06 1.22 down 2.45E-‐01 RRSL_01747 Hypothetical Protein638721320 11.34 10.55 1.91 up 4.19E-‐02 RRSL_01748 Hypothetical Protein638721321 8.95 9.92 1.78 down 7.06E-‐02 RRSL_01749 Atypical orf638721322 10.15 11.34 2.06 down 6.46E-‐02 RRSL_01750 o FenI638721323 10.94 12.02 1.91 down 5.30E-‐02 RRSL_01751 o Hypothetical protein638721325 11.07 11.97 1.7 down 1.87E-‐02 RRSL_01753 o Hypothetical Protein638721327 9.92 10.83 1.7 down 2.47E-‐02 RRSL_01755 o Hypothetical Protein638721328 10.27 11.28 1.83 down 1.08E-‐01 RRSL_01756 o L-‐alanyl-‐D-‐glutamate peptidase( EC:3.4.-‐ )638721329 11.22 12.27 1.87 down 9.07E-‐02 RRSL_01757 o Hypothetical Protein638721330 11.51 11.76 1.08 down 7.06E-‐01 RRSL_01758 o VgrG protein638721331 11.46 11.21 1.31 up 9.35E-‐02 RRSL_01759 possible Phospholipase D638721332 12.26 11.8 1.52 up 4.69E-‐03 RRSL_01760 Hypothetical Protein638721333 10.82 10.87 1.06 up 8.23E-‐01 RRSL_01761 Hypothetical Protein638721334 11.85 12.17 1.13 down 5.14E-‐01 RRSL_01763 Hypothetical Protein638721335 13.6 14.13 1.31 down 1.99E-‐02 RRSL_01764 hypothetical conserved secreted protein638721336 8.36 9.46 1.94 down 4.68E-‐02 RRSL_01766 o c Aspartate aminotransferase( EC:2.6.1.1 )638721337 7.42 7.84 1.21 down 3.45E-‐01 RRSL_01767 Transcriptional regulators, LysR family638721338 7.17 7.72 1.33 down 1.85E-‐01 RRSL_01768 argC ArgC( EC:1.2.1.38 )638721339 6.83 7.47 1.42 down 5.71E-‐02 RRSL_01769 o c Hypothetical cytosolic protein638721340 8.15 7.72 1.49 up 2.48E-‐01 RRSL_01770 o c DNA polymerase III alpha subunit( EC:2.7.7.7 )638721341 13.44 13.11 1.39 up 2.60E-‐01 RRSL_01772 o c Hypothetical Protein638721342 13.96 13.75 1.28 up 7.61E-‐02 RRSL_01773 o c Cation transporters638721344 11.8 11.92 1.02 up 8.48E-‐01 RRSL_01775 o c Protein Translation Elongation Factor G (EF-‐G)638721345 15.83 16.53 1.47 down 5.87E-‐04 RRSL_01831 o SSU ribosomal protein S10P638721346 15.65 16.26 1.38 down 8.62E-‐03 RRSL_01832 o c LSU ribosomal protein L3P638721347 14.9 15.8 1.69 down 5.74E-‐03 RRSL_01833 o c LSU ribosomal protein L1E (= L4P)638721348 16.05 16.62 1.35 down 3.88E-‐03 RRSL_01834 o c LSU ribosomal protein L23P638721349 14.87 15.76 1.68 down 9.17E-‐03 RRSL_01835 o c LSU ribosomal protein L2P638721350 15.78 16.47 1.46 down 9.53E-‐03 RRSL_01836 o c SSU ribosomal protein S19P638721351 15.6 16.16 1.33 down 2.04E-‐02 RRSL_01837 o c LSU ribosomal protein L22P638721352 15.23 15.86 1.4 down 2.78E-‐02 RRSL_01838 o c SSU ribosomal protein S3P638721353 15.12 15.91 1.56 down 1.33E-‐02 RRSL_01839 o c LSU ribosomal protein L16P638721354 15.78 16.21 1.22 down 6.46E-‐02 RRSL_01840 o c LSU ribosomal protein L29P638721355 15.02 15.66 1.42 down 1.31E-‐02 RRSL_01841 o c SSU ribosomal protein S17P638721356 16.01 16.55 1.32 down 3.50E-‐03 RRSL_01842 o c LSU ribosomal protein L14P638721357 16.39 16.9 1.29 down 4.33E-‐03 RRSL_01843 o c LSU ribosomal protein L24P638721358 16.26 16.65 1.19 down 2.62E-‐03 RRSL_01844 o c LSU ribosomal protein L5P638721359 14.8 15.48 1.45 down 2.29E-‐02 RRSL_01845 o c SSU ribosomal protein S14P638721360 14.43 15.43 1.81 down 1.57E-‐02 RRSL_01846 o c SSU ribosomal protein S8P638721361 14.45 15.15 1.47 down 3.77E-‐02 RRSL_01847 o c LSU ribosomal protein L6P638721362 14.64 15.57 1.73 down 2.18E-‐02 RRSL_01848 o c LSU ribosomal protein L18P638721363 15.5 16.11 1.38 down 6.52E-‐04 RRSL_01849 o c SSU ribosomal protein S5P638721364 15.86 16.4 1.31 down 1.25E-‐02 RRSL_01850 o c LSU ribosomal protein L30P638721365 13.17 14.4 2.13 down 5.69E-‐02 RRSL_01851 o c LSU ribosomal protein L15P638721366 16.65 16.72 1.05 up 6.41E-‐01 RRSL_01852 o c Protein translocase subunit secY638721367 16.07 15.96 1.19 up 9.39E-‐02 RRSL_01853 o c Bacterial Protein Translation Initiation Factor 1 (IF-‐1)638721368 16.5 16.69 1.03 down 2.66E-‐01 RRSL_01854 o LSU ribosomal protein L36P638721369 16.21 16.5 1.11 down 1.02E-‐01 RRSL_01855 o c SSU ribosomal protein S13P638721370 16.15 16.61 1.25 down 6.49E-‐03 RRSL_01856 o c SSU ribosomal protein S11P638721371 15.27 15.64 1.17 down 1.84E-‐01 RRSL_01857 o c SSU ribosomal protein S4P638721372 14.31 15.18 1.66 down 2.95E-‐02 RRSL_01858 o c DNA-‐directed RNA polymerase alpha chain( EC:2.7.7.6 )638721373 16.15 16.61 1.25 down 3.29E-‐02 RRSL_01859 o c LSU ribosomal protein L17P638721374 11.86 12.1 1.07 down 6.15E-‐01 RRSL_01860 o c Cu(2+)-‐binding protein CutA638721375 11.33 11.95 1.4 down 2.41E-‐03 RRSL_01861 o c Thiol:disulfide interchange protein DsbD638721376 11.01 12.03 1.84 down 4.63E-‐02 RRSL_01862 o c Delta-‐aminolevulinic acid dehydratase hemB( EC:4.2.1.24 )638721377 11.28 12.01 1.51 down 1.18E-‐01 RRSL_01863 o c GTP-‐binding protein YihA638721379 9.64 10.17 1.31 down 9.06E-‐04 RRSL_01866 o c Heme export protein ResB638721380 11.94 12.07 1.01 up 9.31E-‐01 RRSL_01867 o c Heme export protein ResC / Apocytochrome heme-‐lyase638721381 11.53 12.19 1.44 down 1.33E-‐01 RRSL_01868 o c ATP/GTP binding protein638721382 7.32 8.32 1.8 down 2.12E-‐02 RRSL_01869 o c RNA polymerase ECF-‐type sigma factor638721383 9.81 10.04 1.06 down 4.68E-‐01 RRSL_01870 o Transcriptional regulator638721384 11.77 11.84 1.05 up 8.14E-‐01 RRSL_01871 o c Transmembrane hypothetical protein638721385 9.83 9.47 1.42 up 2.04E-‐01 RRSL_01872 o c Bicyclomycin resistance protein638721388 8.54 9.4 1.65 down 1.46E-‐02 RRSL_01875 o c Frataxin family protein638721389 10 11.05 1.88 down 3.89E-‐03 RRSL_01876 o c Multimodular transpeptidase-‐transglycosylase PBP 1A638721390 13.18 13.57 1.19 down 2.25E-‐01 RRSL_01877 o c pilM PilM638721391 10.91 11.45 1.32 down 5.53E-‐02 RRSL_01878 o c pilN PilN638721392 12.87 13.06 1.04 down 8.06E-‐01 RRSL_01879 o c pilO PilO638721393 12.86 13.55 1.47 down 5.55E-‐03 RRSL_01880 o c pilP PilP638721394 11.62 12.69 1.9 down 1.81E-‐02 RRSL_01881 o c pilQ PilQ638721395 12.21 12.57 1.16 down 3.65E-‐01 RRSL_01884 o c 3-‐dehydroquinate synthase( EC:4.2.3.4,EC:4.6.1.3 )638721396 11.11 10.83 1.34 up 1.16E-‐01 RRSL_01885 o c Deoxyguanosinetriphosphate triphosphohydrolase( EC:3.1.5.1 )

638721398 10.01 9.63 1.43 up 2.11E-‐01 RRSL_01887 o c Hypothetical cytosolic protein638721399 10.53 10.81 1.1 down 6.25E-‐01 RRSL_01888 o c Glutamate synthase [NADPH] large chain( EC:1.4.1.13 )638721400 10.47 10.5 1.08 up 6.47E-‐01 RRSL_01889 o c Glutamate synthase [NADPH] small chain( EC:1.4.1.13 )638721401 8.47 7.9 1.63 up 6.49E-‐02 RRSL_01890 o c Plasmid pENH91 DNA, SacI-‐KpnI region containing chlorocatechol degradative operon638721403 11.42 11.82 1.2 down 6.59E-‐02 RRSL_01892 o c toluene tolerance protein TTG2B638721404 14.15 14.24 1.04 up 8.45E-‐01 RRSL_01893 o c toluene tolerance protein TTG2C638721405 13.84 14.29 1.24 down 3.75E-‐02 RRSL_01894 o c Lipoprotein638721408 11.2 11.85 1.43 down 6.51E-‐02 RRSL_01897 o c ABC transporter ATP-‐binding protein638721409 10.85 11.34 1.27 down 5.31E-‐02 RRSL_01898 o c ABC transporter permease protein638721410 12.44 13.14 1.47 down 6.34E-‐03 RRSL_01899 o c BolA protein638721411 12.02 12.77 1.52 down 2.09E-‐02 RRSL_01900 o c UDP-‐N-‐acetylglucosamine 1-‐carboxyvinyltransferase( EC:2.5.1.7 )638721414 10.42 11.4 1.8 down 1.96E-‐02 RRSL_01903 o c Histidinol-‐phosphate aminotransferase( EC:2.6.1.9 )638721417 9.42 8.95 1.53 up 3.51E-‐02 RRSL_01906 o c tRNA(Ile)-‐lysidine synthetase TilS638721418 12.83 13.16 1.14 down 8.37E-‐02 RRSL_01907 o c Acetyl-‐coenzyme A carboxylase carboxyl transferase subunit alpha( EC:6.4.1.2 )638721419 10.89 11.39 1.28 down 1.05E-‐01 RRSL_01908 o c DNA-‐3-‐methyladenine glycosylase II( EC:3.2.2.21 )638721420 11.78 12.45 1.44 down 1.17E-‐01 RRSL_01909 o c Cysteinyl-‐tRNA synthetase( EC:6.1.1.16 )638721421 11.51 10.72 1.9 up 2.28E-‐01 RRSL_01910 o c Tetratricopeptide repeat family protein638721422 14.98 15.25 1.09 down 1.98E-‐01 RRSL_01911 o c Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638721423 13.64 14.3 1.43 down 2.65E-‐02 RRSL_01912 o c Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638721424 9.77 10.09 1.13 down 4.47E-‐01 RRSL_01913 o c UDP-‐2,3-‐diacylglucosamine hydrolase( EC:3.6.1.-‐ )638721425 9.86 10.74 1.67 down 6.16E-‐02 RRSL_01914 o c Serine acetyltransferase( EC:2.3.1.30 )638721426 11.1 11.56 1.25 down 8.49E-‐02 RRSL_01916 o c RRNA methylase, SpoU family638721427 13.87 13.92 1.06 up 2.60E-‐01 RRSL_01915 o Myo-‐inositol-‐1(or 4)-‐monophosphatase( EC:3.1.3.25 )638721428 9.02 9.94 1.71 down 1.14E-‐02 RRSL_01917 o c Transcriptional regulator, MerR family638721429 10.19 11.28 1.94 down 2.40E-‐02 RRSL_01918 o c GMP synthase (glutamine-‐hydrolyzing)( EC:6.3.5.2 )638721431 9.5 10.43 1.72 down 3.06E-‐02 RRSL_01920 o c Hypothetical cytosolic protein638721433 8.28 7.7 1.64 up 1.32E-‐01 RRSL_01922 o c Probable transmembrane methyl-‐accepting chemotaxis protein638721434 9.81 10.35 1.31 down 5.81E-‐02 RRSL_01923 o 2,5-‐diketo-‐D-‐gluconic acid reductase( EC:1.1.1.274 )638721435 8.17 7.5 1.76 up 2.33E-‐01 RRSL_01924 o Transmembrane efflux protein638721436 7.51 7.27 1.3 up 2.12E-‐01 RRSL_01925 o Transcriptional regulators, LysR family638721437 10.35 11.49 2 down 6.09E-‐03 RRSL_01926 o c mutS MutS638721438 9.53 10.4 1.66 down 7.23E-‐03 RRSL_01927 o c Hypothetical Protein638721439 13.35 13.69 1.15 down 4.82E-‐01 RRSL_01929 o c Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638721440 11.14 11.78 1.4 down 4.04E-‐02 RRSL_01928 o c Hypothetical cytosolic protein638721441 13.37 14.59 2.11 down 5.82E-‐02 RRSL_01930 Hypothetical Protein638721443 12.27 13.3 1.85 down 8.53E-‐03 RRSL_01933 o c Dihydrodipicolinate synthase( EC:4.2.1.52 )638721445 10.82 11.84 1.85 down 2.97E-‐02 RRSL_01935 o c Tryptophanyl-‐tRNA synthetase( EC:6.1.1.2 )638721446 12.05 11.83 1.29 up 1.80E-‐01 RRSL_01936 o c Membrane metalloprotease638721447 9.35 10.13 1.56 down 1.90E-‐04 RRSL_01937 o c Sua5/YciO/YrdC/YwlC family protein638721449 8.73 9.03 1.12 down 5.52E-‐01 RRSL_01940 o Lipoprotein638721450 7.17 7.41 1.07 down 6.55E-‐01 RRSL_01941 o Hypothetical Protein638721451 10.44 9.32 2.39 up 7.27E-‐02 RRSL_01942 o c Esterase( EC:3.1.1.1 )638721452 9.58 10.05 1.25 down 4.00E-‐02 RRSL_01944 o Hypothetical protein638721453 11.45 11.77 1.14 down 2.74E-‐01 RRSL_01943 o c Putative acetyltransferase/acyltransferase638721454 11.24 11.78 1.32 down 4.46E-‐02 RRSL_01945 o c 33 kDa chaperonin638721455 10.82 11.06 1.07 down 4.01E-‐01 RRSL_01946 o c Hypothetical Protein638721456 13.88 13.17 1.81 up 7.24E-‐03 RRSL_01947 o c ftsB FtsB638721457 12.56 13.19 1.41 down 1.24E-‐01 RRSL_01948 o c Enolase( EC:4.2.1.11 )638721458 10.91 11.82 1.7 down 6.51E-‐02 RRSL_01949 o c Hypothetical cytosolic protein638721459 12.12 12.93 1.6 down 6.56E-‐02 RRSL_01950 o c 2-‐dehydro-‐3-‐deoxyphosphooctonate aldolase( EC:2.5.1.55,EC:4.1.2.16 )638721460 12.18 12.93 1.53 down 1.18E-‐01 RRSL_01951 o c CTP synthase; pyrG( EC:6.3.4.2 )638721461 8.97 9.25 1.1 down 6.53E-‐01 RRSL_01952 o c Putative hydrolase638721462 11.94 11.84 1.18 up 2.66E-‐02 RRSL_01953 o c Hypothetical protein638721463 9.2 10.14 1.74 down 2.18E-‐02 RRSL_01954 o c Transglutaminase-‐like enzymes, putative cysteine proteases638721464 10.31 10.64 1.15 down 1.67E-‐01 RRSL_01955 o c Hypothetical protein638721465 9.75 10.26 1.3 down 4.29E-‐02 RRSL_01956 o c Hypothetical cytosolic protein638721466 7.93 7.98 1.06 up 7.26E-‐01 RRSL_01957 o c DNA translocation competence protein ComA638721467 8.98 9.88 1.69 down 4.00E-‐02 RRSL_01958 o c Sec-‐independent protein translocase protein tatD( EC:3.1.21.-‐ )638721469 12 12.17 1.02 down 9.25E-‐01 RRSL_01961 lolC LolC638721470 9.05 9.86 1.59 down 1.63E-‐02 RRSL_01960 o c Single-‐stranded-‐DNA-‐specific exonuclease recJ( EC:3.1.-‐ )638721471 9.72 8.6 2.4 up 8.93E-‐02 RRSL_02576 hypothetical protein638721472 10.1 10.31 1.05 down 8.34E-‐01 RRSL_02577 Conserved hypothetical protein638721473 9.33 9.27 1.15 up 5.63E-‐01 RRSL_02578 putative chromosome segregation ATPases638721474 10.54 10.55 1.1 up 7.49E-‐01 RRSL_02579 hypothetical protein638721476 12.57 12.53 1.14 up 2.72E-‐01 RRSL_02580 o c hypothetical protein638721477 9.09 9.89 1.58 down 3.99E-‐02 RRSL_02581 o c FAD/FMN-‐containing dehydrogenases638721479 10.94 11.59 1.43 down 2.39E-‐02 RRSL_02583 o c Ribonuclease BN( EC:3.1.-‐ )638721480 11.97 11.69 1.33 up 1.13E-‐01 RRSL_02584 o c hypothetical protein638721481 8.39 8.83 1.23 down 2.80E-‐01 RRSL_02586 o c O-‐acetylhomoserine sulfhydrylase / O-‐acetylserine sulfhydrylase( EC:4.2.99.10,EC:4.2.99.8 )638721482 12.96 13.36 1.19 down 4.16E-‐01 RRSL_02587 o c CBS domain containing protein638721483 10.38 11.34 1.76 down 5.68E-‐04 RRSL_02588 o c Macrolide-‐efflux protein / 1-‐acyl-‐sn-‐glycerol-‐3-‐phosphate acyltransferase( EC:2.3.1.51 )638721484 11.88 12.73 1.63 down 5.12E-‐02 RRSL_02589 o c Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638721486 9.89 10.68 1.57 down 1.12E-‐02 RRSL_02591 o c Electron transfer flavoprotein-‐ubiquinone oxidoreductase( EC:1.5.5.1 )638721487 12.01 12.44 1.22 down 1.23E-‐01 RRSL_02592 o c Gluconate 5-‐dehydrogenase( EC:1.1.1.69 )638721488 9.12 9.69 1.34 down 1.20E-‐01 RRSL_02593 o c hypothetical protein638721489 12.63 12.71 1.04 up 7.98E-‐01 RRSL_02594 o c hypothetical protein

638721490 12.64 12.57 1.16 up 3.89E-‐01 RRSL_02595 o c hypothetical protein638721491 10.17 10.78 1.38 down 2.73E-‐01 RRSL_02596 o c D-‐beta-‐hydroxybutyrate dehydrogenase( EC:1.1.1.30 )638721493 9.69 10.68 1.8 down 6.21E-‐02 RRSL_02598 o c GTP pyrophosphokinase / Guanosine-‐3',5'-‐bis(Diphosphate) 3'-‐pyrophosphohydrolase( EC:2.7.6.5,EC:3.1.7.2 )638721494 12.23 13.1 1.66 down 1.53E-‐01 RRSL_RNA023 ( tRNA )638721495 12.08 13.18 1.94 down 4.15E-‐02 RRSL_02599 o c Threonyl-‐tRNA synthetase( EC:6.1.1.3 )638721496 15.59 15.36 1.3 up 2.65E-‐02 RRSL_02601 o c Bacterial Protein Translation Initiation Factor 3 (IF-‐3)638721497 16.55 16.77 1.06 down 7.61E-‐02 RRSL_02602 o c LSU ribosomal protein L35P638721498 14.37 14.74 1.17 down 5.98E-‐01 RRSL_02603 o c LSU ribosomal protein L20P638721499 12.34 13.17 1.61 down 8.19E-‐02 RRSL_02604 o c Phenylalanyl-‐tRNA synthetase alpha chain( EC:6.1.1.20 )638721500 13.94 14.58 1.42 down 2.08E-‐02 RRSL_02605 o c Phenylalanyl-‐tRNA synthetase beta chain( EC:6.1.1.20 )638721501 12.29 13.24 1.76 down 7.25E-‐02 RRSL_02606 o c Integration host factor alpha-‐subunit638721502 10.84 11.77 1.72 down 1.58E-‐01 RRSL_02607 o c Transcriptional regulator, MerR family638721503 9.89 10.83 1.74 down 1.29E-‐01 RRSL_RNA024 ( tRNA )638721504 11.56 11.77 1.05 down 7.69E-‐01 RRSL_02608 hypothetical protein638721505 10.71 10.67 1.13 up 4.36E-‐01 RRSL_02609 hypothetical protein638721508 10.16 9.89 1.33 up 2.50E-‐01 RRSL_02612 hypothetical protein638721509 8.19 8.74 1.32 down 3.12E-‐01 RRSL_02613 Conserved hypothetical protein638721511 12.81 12.65 1.24 up 2.94E-‐01 RRSL_02615 hypothetical protein638721512 11.64 11.41 1.29 up 3.67E-‐01 RRSL_02617 hypothetical protein638721513 12.93 13.06 1.01 up 9.64E-‐01 RRSL_02618 VgrG protein638721514 11.1 11.81 1.48 down 2.19E-‐01 RRSL_02619 hypothetical protein638721515 11.66 11.97 1.13 down 7.05E-‐01 RRSL_02620 hypothetical protein638721516 10.84 11.43 1.37 down 4.05E-‐01 RRSL_02621 hypothetical protein638721517 12.98 13.01 1.08 up 7.01E-‐01 RRSL_02622 hypothetical protein638721518 13.56 12.8 1.87 up 1.55E-‐03 RRSL_02623 hypothetical protein638721519 13.64 13.39 1.32 up 1.11E-‐02 RRSL_02624 hypothetical protein638721520 13.4 12.78 1.69 up 2.24E-‐02 RRSL_02625 hypothetical protein638721521 10.85 11.29 1.22 down 6.00E-‐01 RRSL_02626 hypothetical protein638721522 8.26 8.51 1.08 down 8.32E-‐01 RRSL_02627 hypothetical protein638721523 11.45 11.33 1.2 up 4.48E-‐01 RRSL_02628 hypothetical protein638721524 12.68 12.24 1.5 up 4.17E-‐02 RRSL_02630 hypothetical protein possibly involved in aromatic compound catabolism638721526 9.19 9.49 1.11 down 6.92E-‐01 RRSL_01674 o Transporter, drug/metabolite exporter family638721527 12.32 13.22 1.7 down 1.19E-‐03 RRSL_01675 o c Hypothetical membrane spanning protein638721529 8.63 9.71 1.91 down 1.97E-‐02 RRSL_01677 o c Glutamate racemase( EC:5.1.1.3 )638721530 11.96 12.55 1.37 down 1.85E-‐01 RRSL_01678 o c C4-‐dicarboxylate transport protein638721531 9.51 9.32 1.26 up 2.10E-‐01 RRSL_01679 o c Hypothetical Protein638721532 10.44 10.29 1.22 up 1.21E-‐01 RRSL_01680 o c Transcriptional regulator, ArsR family638721533 7.72 7.14 1.64 up 1.98E-‐02 RRSL_01681 o c ATP-‐dependent Zn proteases638721534 13.82 14.03 1.05 down 6.86E-‐01 RRSL_01682 o c TonB protein638721535 11.43 12.46 1.85 down 3.18E-‐02 RRSL_01683 o c TolQ protein638721536 11.26 11.99 1.5 down 5.78E-‐02 RRSL_01684 o c Hypothetical Protein638721537 13.64 14.74 1.94 down 1.01E-‐02 RRSL_01685 o c Hypothetical Protein638721538 11.82 12.43 1.38 down 1.48E-‐03 RRSL_01686 o c glcG GlcG638721539 9.67 9.98 1.13 down 5.96E-‐01 RRSL_01687 o c Integral membrane protein638721540 12.33 11.56 1.87 up 2.94E-‐02 RRSL_01688 o c Hypothetical Protein638721541 8.69 8.12 1.63 up 9.01E-‐02 RRSL_01689 o c Hypothetical Protein638721544 9.84 10.56 1.49 down 4.20E-‐02 RRSL_01692 o 1,4-‐alpha-‐glucan branching enzyme( EC:2.4.1.18 )638721546 7.68 7.32 1.41 up 5.38E-‐02 RRSL_01694 Hypothetical Protein638721547 7.45 7.13 1.38 up 1.68E-‐01 RRSL_01695 hmuU HmuU638721548 7.56 7.58 1.09 up 6.89E-‐01 RRSL_01696 Hemin-‐binding periplasmic protein hmuT precursor638721549 7.45 7.15 1.36 up 3.93E-‐01 RRSL_01697 o hmuS HmuS638721550 8.57 7.93 1.73 up 2.40E-‐01 RRSL_01698 o Hemin receptor638721551 15.77 15.7 1.16 up 4.87E-‐01 RRSL_01699 o c Peroxiredoxin( EC:1.11.-‐ )638721552 11.47 11.84 1.17 down 3.05E-‐01 RRSL_01700 o c Peroxiredoxin reductase (NAD(P)H)( EC:1.6.4.-‐ )638721553 9.69 9.7 1.09 up 5.34E-‐01 RRSL_01702 o c Ferric uptake regulation protein638721554 11.96 10.95 2.22 up 8.48E-‐02 RRSL_01703 Hypothetical Protein638721555 9.5 8.9 1.68 up 6.79E-‐02 RRSL_01704 o c Hypothetical Protein638721556 7.61 8.71 1.94 down 7.58E-‐03 RRSL_01705 o c probable transmembrane638721557 9.05 9.7 1.42 down 2.18E-‐02 RRSL_01706 o c Ferrous iron transport protein B638721559 9.87 9.79 1.16 up 2.80E-‐01 RRSL_01708 o c Sensory transduction protein kinase( EC:2.7.3.-‐ )638721560 10.44 9.93 1.58 up 1.41E-‐02 RRSL_01709 o c Hypothetical Protein638721561 7.16 7.03 1.2 up 2.75E-‐01 RRSL_01710 o c Probable aerotaxis receptor (aer2)638721562 8.26 8.74 1.26 down 1.05E-‐01 RRSL_01711 o c Hypothetical Protein638721563 10.3 10.5 1.04 down 7.48E-‐01 RRSL_01712 o c Siderophore-‐interacting protein638721564 11.64 11.27 1.42 up 1.14E-‐01 RRSL_01713 o c Transcriptional regulator638721565 9.23 8.84 1.44 up 3.18E-‐01 RRSL_01714 o c Pyrrolidone-‐carboxylate peptidase( EC:3.4.19.3 )638721566 7.29 7.57 1.11 down 5.43E-‐01 RRSL_01715 o c Hypothetical Protein638721569 8.5 8.11 1.45 up 3.42E-‐01 RRSL_01718 6-‐aminohexanoate-‐dimer hydrolase( EC:3.5.1.46 )638721570 8.67 9.18 1.29 down 6.34E-‐02 RRSL_01719 o Acetyltransferase( EC:2.3.1.-‐ )638721571 8.96 9.17 1.05 down 7.24E-‐01 RRSL_01720 o Carboxypeptidase G2 precursor( EC:3.4.17.11 )638721572 8.65 7.46 2.52 up 1.16E-‐01 RRSL_01721 Phosphatidylserine decarboxylase( EC:4.1.1.65 )638721573 13.15 12.8 1.4 up 3.29E-‐02 RRSL_01722 Tetracycline resistance protein638721574 7.57 7.74 1.02 down 9.18E-‐01 RRSL_01723 Tetracycline resistance protein638721576 8.66 8.22 1.49 up 4.12E-‐01 RRSL_01725 o Hypothetical Protein638721577 7.93 7.44 1.55 up 2.30E-‐01 RRSL_01726 o Hypothetical Protein638721578 7.52 7.58 1.06 up 8.72E-‐01 RRSL_01727 DNA-‐binding protein

638721579 9.64 9.51 1.21 up 6.54E-‐01 RRSL_01728 o Hypothetical Protein638721580 9.03 7.71 2.77 up 6.70E-‐02 RRSL_01729 Hypothetical Protein638721581 8.59 8.05 1.6 up 2.02E-‐01 RRSL_01730 Hypothetical Protein638721582 10.61 11.46 1.64 down 1.09E-‐01 RRSL_01779 o paaA PaaA638721583 7.3 8.08 1.56 down 1.43E-‐01 RRSL_01781 o paaC PaaC638721584 9.13 9.03 1.18 up 4.17E-‐01 RRSL_01782 o Phenylacetyl-‐CoA 2-‐monooxygenase electron transfer component( EC:1.14.13.-‐ )638721586 9.12 9.61 1.28 down 3.17E-‐01 RRSL_01784 o Hypothetical Protein638721588 12.5 13.21 1.48 down 4.34E-‐02 RRSL_01786 Hypothetical Protein638721589 12.17 12.94 1.55 down 3.98E-‐02 RRSL_01787 Hypothetical Protein638721590 10.57 11.12 1.33 down 2.24E-‐01 RRSL_01788 Hypothetical Protein638721592 13.72 14.37 1.42 down 1.76E-‐01 RRSL_01790 Hypothetical Protein638721593 7.41 8.2 1.56 down 8.47E-‐02 RRSL_01791 Hypothetical Protein638721594 11.04 11.24 1.04 down 8.54E-‐01 RRSL_01793 o ABC transporter ATP-‐binding protein638721595 11.77 12.01 1.07 down 7.97E-‐01 RRSL_01794 o c Amino acid ABC transporter permease protein638721596 11.75 12.04 1.11 down 7.29E-‐01 RRSL_01795 o ABC transporter amino acid-‐binding protein638721597 8.3 9.2 1.69 down 2.24E-‐02 RRSL_01796 o Transcriptional regulator, AsnC family638721598 13.36 12.51 1.98 up 1.13E-‐01 RRSL_01797 o Ornithine cyclodeaminase( EC:4.3.1.12 )638721599 10.34 10.14 1.27 up 4.60E-‐01 RRSL_01798 o c Hypothetical protein638721600 10.34 10.42 1.05 up 8.30E-‐01 RRSL_01799 o c Phosphoglycolate phosphatase( EC:3.1.3.18 )638721601 7.26 8 1.51 down 7.19E-‐02 RRSL_01800 o c Hypothetical Protein638721602 14.41 13.73 1.77 up 6.51E-‐03 RRSL_01801 o Hypothetical Protein638721605 8.74 8.95 1.04 down 7.31E-‐01 RRSL_01804 o c transcriptional regulator transmembrane sensory transduction histidine kinase for Co, Zn, Cd resistance czcS( EC:2.7.3.-‐ )638721606 10.27 11.12 1.64 down 4.86E-‐02 RRSL_01806 o c czcR CzcR638721607 8.78 8.39 1.45 up 2.18E-‐01 RRSL_01805 Hypothetical Protein638721609 8.08 8.32 1.08 down 6.77E-‐01 RRSL_01807 OM efflux protein (porin)638721610 9.54 9.13 1.47 up 2.08E-‐01 RRSL_01809 putative multicoper oxidase638721611 11.46 12.67 2.09 down 5.36E-‐02 RRSL_01810 o c Hypothetical protein638721612 9.44 10.26 1.6 down 1.59E-‐01 RRSL_01812 o c Probable Cobalt-‐zinc-‐cadmium outer membrane resistance protein (czcC)638721613 9.32 9.81 1.27 down 3.56E-‐01 RRSL_01813 o c czcB CzcB638721614 9.91 10.86 1.76 down 1.45E-‐02 RRSL_01814 o c Cobalt-‐zinc-‐cadmium resistance protein (czcA)638721616 7.57 8.59 1.84 down 1.64E-‐02 RRSL_01816 Hypothetical Protein638721617 9.84 10.17 1.14 down 2.33E-‐01 RRSL_01817 o c Oxidoreductase D-‐3-‐phosphoglycerate dehydrogenase (ldhA)638721618 10.09 9.2 2.04 up 6.25E-‐02 RRSL_01818 o c Hypothetical Protein638721620 8.87 8.21 1.74 up 2.47E-‐01 RRSL_01820 o c Bacteriophage N4 adsorption protein B638721621 7.55 7.45 1.18 up 4.78E-‐01 RRSL_01821 o c Hypothetical Protein638721622 6.76 7.31 1.32 down 8.01E-‐02 RRSL_01822 Hypothetical Protein638721623 8.34 8.24 1.18 up 3.70E-‐01 RRSL_01823 o c Probable UDP-‐N-‐acetylglucosamine 2-‐epimerase( EC:5.1.3.14 )638721624 7.91 8.04 1.01 up 9.75E-‐01 RRSL_01824 o Hypothetical Protein638721625 10.68 10.3 1.44 up 8.84E-‐02 RRSL_01825 o c Hypothetical Protein638721628 10.3 10.68 1.18 down 4.47E-‐01 RRSL_01828 Hypothetical Protein638721629 10.72 10.56 1.23 up 5.32E-‐01 RRSL_01829 Hypothetical Protein638721630 12.48 12.34 1.22 up 9.18E-‐03 RRSL_01145 o c CDP-‐diacylglycerol-‐-‐glycerol-‐3-‐phosphate 3-‐phosphatidyltransferase( EC:2.7.8.5 )638721631 9.29 9.66 1.17 down 2.89E-‐01 RRSL_01146 o c Excinuclease ABC subunit C638721632 10.43 10.79 1.16 down 3.66E-‐01 RRSL_01147 o c Hypothetical cytosolic protein638721633 14.25 14.77 1.3 down 1.67E-‐01 RRSL_01148 o c Protein Translation Elongation Factor P (EF-‐P)638721634 9.65 10.72 1.9 down 3.72E-‐02 RRSL_01149 o c Anhydromuramoyl-‐peptide exo-‐beta-‐N-‐acetylglucosaminidase( EC:3.2.1.-‐,EC:3.2.1.52 )638721637 9.74 10.3 1.34 down 4.27E-‐02 RRSL_01152 o c recO RecO638721638 11.49 12.36 1.66 down 1.35E-‐01 RRSL_01153 o c era Era638721639 11.18 11.52 1.14 down 6.07E-‐01 RRSL_01154 o c Ribonuclease III( EC:3.1.26.3 )638721640 13.5 13.95 1.23 down 1.96E-‐01 RRSL_01155 o c Hypothetical Protein638721641 12.89 13.55 1.43 down 2.80E-‐03 RRSL_01156 o c Signal peptidase I( EC:3.4.21.89 )638721642 12.09 12.55 1.24 down 2.47E-‐01 RRSL_01157 o c lepA LepA638721643 11.09 11.95 1.65 down 7.02E-‐02 RRSL_01158 o c Glutaredoxin638721644 12.84 13.72 1.66 down 8.52E-‐02 RRSL_01159 o c Protease Do( EC:3.4.21.-‐ )638721645 13.24 13.67 1.22 down 2.35E-‐01 RRSL_01160 o c Sigma-‐E factor regulatory protein rseB precursor638721646 13.82 14.33 1.3 down 1.69E-‐01 RRSL_01161 o c Hypothetical Protein638721647 12.94 13.52 1.35 down 2.29E-‐01 RRSL_01162 o c RNA polymerase sigma-‐E factor638721648 14.78 14.98 1.04 down 7.16E-‐01 RRSL_01165 o c 3-‐oxoacyl-‐[acyl-‐carrier-‐protein] synthase( EC:2.3.1.41 )638721649 14.15 15.2 1.88 down 1.43E-‐02 RRSL_01166 o c 3-‐oxoacyl-‐[acyl-‐carrier protein] reductase( EC:1.1.1.100 )638721653 14.54 15.03 1.28 down 2.39E-‐01 RRSL_01170 o c LSU ribosomal protein L32P638721654 15.46 15.76 1.12 down 6.53E-‐01 RRSL_01171 o c Hypothetical Protein638721657 10.47 11.5 1.85 down 5.87E-‐04 RRSL_01174 o c protease IV( EC:3.4.-‐ )638721658 11.85 12.03 1.02 down 8.96E-‐01 RRSL_01175 o c Rieske (2Fe-‐2S) domain protein638721659 8.62 9.6 1.79 down 2.53E-‐02 RRSL_01176 o c Hypothetical Protein638721660 10.17 11.13 1.76 down 3.64E-‐02 RRSL_01177 o c Ribosomal large subunit pseudouridine synthase C( EC:4.2.1.70 )638721661 11.18 12.5 2.26 down 8.95E-‐02 RRSL_01178 o c Ribonuclease E( EC:3.1.4.-‐ )638721662 10.04 10.53 1.27 down 2.06E-‐01 RRSL_01179 o c Molybdenum cofactor biosynthesis protein A638721663 9.84 10.25 1.2 down 1.93E-‐01 RRSL_01180 o c Molybdopterin-‐guanine dinucleotide biosynthesis protein A638721664 10.05 9.98 1.16 up 1.10E-‐01 RRSL_01181 o c Molybdopterin biosynthesis MoeA protein638721665 13.39 13.4 1.09 up 7.94E-‐01 RRSL_01182 o c Hypothetical Protein638721666 10.41 10.71 1.12 down 3.12E-‐01 RRSL_01183 o c RmuC family protein638721667 9.56 9.97 1.2 down 3.60E-‐01 RRSL_01185 o c 2-‐hydroxyacid dehydrogenase( EC:1.1.1.-‐ )638721668 9.64 10.01 1.18 down 3.47E-‐01 RRSL_01186 o c Hypothetical protein638721670 10.44 11.08 1.41 down 4.20E-‐02 RRSL_01188 o c Nicotinate phosphoribosyltransferase( EC:2.4.2.11 )638721674 12.9 13.87 1.78 down 2.50E-‐03 RRSL_01192 o c Lysyl-‐tRNA synthetase( EC:6.1.1.6 )638721676 11.73 11.7 1.13 up 5.70E-‐01 RRSL_01194 o c Hypothetical cytosolic protein

638721677 10.74 11.52 1.56 down 7.30E-‐03 RRSL_01195 o c Ferredoxin, 2Fe-‐2s638721678 8.25 9.17 1.71 down 8.29E-‐03 RRSL_01196 o c hscA HscA638721679 9.4 10.09 1.45 down 4.75E-‐02 RRSL_01197 o c hscB HscB638721680 10.2 11.19 1.81 down 4.08E-‐02 RRSL_01198 o c Hypothetical Protein638721681 12.4 12.65 1.08 down 7.10E-‐01 RRSL_01199 o c HesB protein family638721682 14.02 14.04 1.09 up 4.97E-‐01 RRSL_01200 o c IscU protein638721683 12.38 12.67 1.11 down 5.62E-‐01 RRSL_01201 Cysteine desulfhydrase / Selenocysteine lyase( EC:4.4.1.16 )638721684 11.08 11.75 1.45 down 2.14E-‐01 RRSL_01202 o c Cysteine desulfhydrase / Selenocysteine lyase( EC:4.4.1.16 )638721685 14.58 14.71 1.01 up 9.67E-‐01 RRSL_01622 Hypothetical Protein638721686 11.1 11.06 1.13 up 5.50E-‐01 RRSL_01623 Hypothetical Protein638721687 9.44 10.16 1.5 down 2.00E-‐01 RRSL_01624 o Hypothetical Protein638721689 9.64 9.07 1.64 up 2.37E-‐02 RRSL_01626 o hypothetical Transmembrane protein638721690 9.76 9.29 1.52 up 1.42E-‐01 RRSL_01627 o plcN PlcN( EC:3.1.4.3 )638721691 10.13 9.66 1.53 up 2.07E-‐01 RRSL_01628 o c Hypothetical Protein638721692 8.71 9.18 1.26 down 1.18E-‐01 RRSL_01629 o c Transcriptional regulator638721693 8.77 9.01 1.07 down 7.22E-‐01 RRSL_01630 o c Hypothetical exported protein638721694 9.64 9.9 1.08 down 5.17E-‐01 RRSL_01631 o c ABC transporter ATP-‐binding protein638721695 9.17 10.07 1.69 down 6.15E-‐03 RRSL_01633 o c ABC transporter permease protein638721696 10.85 8.45 5.83 up 5.52E-‐02 RRSL_01632 o c Biotin operon repressor / Biotin-‐-‐[acetyl-‐CoA-‐carboxylase] synthetase( EC:6.3.4.15 )638721697 7.96 8.44 1.26 down 4.14E-‐01 RRSL_01634 o c Bvg accessory factor638721698 10.07 10.43 1.17 down 6.04E-‐02 RRSL_01635 o c Hypothetical Protein638721699 8.93 9.27 1.14 down 1.89E-‐01 RRSL_01636 o c D-‐glycero-‐D-‐manno-‐heptose-‐1-‐phosphate adenylyltransferase( EC:2.7.7.-‐ )638721700 12.61 13.34 1.5 down 9.50E-‐03 RRSL_01637 o c Hypothetical Protein638721701 8.91 8.86 1.14 up 5.43E-‐01 RRSL_01638 o c Glutathione peroxidase( EC:1.11.1.9 )638721702 9.33 9.9 1.35 down 5.22E-‐02 RRSL_01639 o c Serine protease( EC:3.4.21.-‐ )638721703 13.7 13.35 1.4 up 3.07E-‐01 RRSL_01640 o c Hypothetical Protein638721704 11.85 11.99 1 down 9.84E-‐01 RRSL_01641 o c Enoyl-‐CoA hydratase( EC:4.2.1.17 )638721705 8.72 8.62 1.19 up 5.59E-‐01 RRSL_01642 Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638721706 10.44 10.17 1.33 up 3.22E-‐01 RRSL_01644 o c Transcriptional regulator, IclR family638721707 11.64 11.07 1.63 up 3.25E-‐01 RRSL_01646 Fumarylacetoacetase( EC:3.7.1.2 )638721708 8.43 8.79 1.16 down 1.12E-‐01 RRSL_01647 o c 3-‐oxoadipate enol-‐lactonase( EC:3.1.1.24 )638721709 11.96 12.06 1.03 up 9.07E-‐01 RRSL_01648 o c Hypothetical Protein638721710 9.14 9.49 1.15 down 5.54E-‐01 RRSL_01649 o c sulfide dehydrogenase precursor638721711 11.23 12.21 1.78 down 2.32E-‐03 RRSL_01650 o c 5-‐methyltetrahydrofolate-‐-‐homocysteine methyltransferase homocysteine-‐binding subunit( EC:2.1.1.13 )638721712 11.22 11.8 1.36 down 8.40E-‐04 RRSL_01651 o c 5-‐methyltetrahydrofolate-‐-‐homocysteine methyltransferase cobalamin-‐binding subunit( EC:2.1.1.13 )638721713 13.48 13.52 1.08 up 7.54E-‐01 RRSL_01652 o c Hypothetical Protein638721714 10.18 10.44 1.09 down 6.41E-‐01 RRSL_01653 Hypothetical Protein638721715 13.08 13.3 1.06 down 3.98E-‐01 RRSL_01654 o c transcriptional regulator/response regulator, LuxR638721716 12.81 13.34 1.31 down 7.34E-‐02 RRSL_01655 o c Hypothetical Protein638721717 12.34 12.39 1.07 up 2.16E-‐01 RRSL_01656 o c Hypothetical Protein638721718 10.26 10.75 1.27 down 5.23E-‐02 RRSL_01657 o c Sensory transduction protein kinase( EC:2.7.3.-‐ )638721720 12.53 13.34 1.59 down 1.66E-‐02 RRSL_01659 o c Hypothetical Protein638721722 11.49 12.47 1.79 down 6.61E-‐04 RRSL_01661 o c ftsN FtsN638721723 14.57 15.58 1.84 down 2.24E-‐03 RRSL_01662 o c dsbA DsbA638721725 9.66 10.71 1.88 down 5.20E-‐03 RRSL_01664 o c Iron(III) dicitrate-‐binding protein638721726 8.82 9.65 1.61 down 2.64E-‐02 RRSL_01665 o c JemB638721727 8.71 9.4 1.47 down 6.40E-‐02 RRSL_01666 o c zinc metallohydrolase, glyoxalase ii family638721728 9.29 9.49 1.04 down 8.78E-‐01 RRSL_01667 o c probable transcriptional regulator638721729 11.5 10.62 2.03 up 7.63E-‐02 RRSL_01668 o c Isovaleryl-‐CoA dehydrogenase( EC:1.3.99.10 )638721731 11.45 10.88 1.63 up 7.27E-‐02 RRSL_01670 o c Isocitrate dehydrogenase kinase/phosphatase (IDH kinase/phosphatase)( EC:2.7.1.116,EC:3.1.3.-‐ )638721733 10.08 10.56 1.27 down 1.30E-‐01 RRSL_01672 Transcriptional regulator638721735 10.33 11.15 1.61 down 1.36E-‐02 RRSL_01532 o c Threonine synthase( EC:4.2.3.1 )638721736 10.17 10.23 1.06 up 7.78E-‐01 RRSL_01533 o c Uracil DNA glycosylase superfamily protein638721737 10.89 11.2 1.13 down 3.24E-‐01 RRSL_01534 o c Molybdopterin biosynthesis MoeA protein638721738 7.54 8.28 1.52 down 7.82E-‐02 RRSL_01535 o c Molybdopterin converting factor, small subunit638721739 10.91 11.28 1.17 down 2.18E-‐02 RRSL_01536 o c Molybdopterin converting factor, large subunit638721740 10.84 10.84 1.1 up 6.81E-‐01 RRSL_01537 o c CrcB family protein638721741 9.24 9.79 1.33 down 1.80E-‐01 RRSL_01538 o c hydroxybutyrate-‐dimer hydrolase( EC:3.1.1.22 )638721742 12.29 13.27 1.78 down 2.66E-‐02 RRSL_01539 o c ClpB protein638721743 9.26 8.16 2.36 up 1.54E-‐01 RRSL_01540 o c Sulfate-‐binding protein638721744 11.42 10.21 2.55 up 8.81E-‐02 RRSL_01541 o FMN reductase( EC:1.5.1.29 )638721745 11.56 9.24 5.52 up 7.21E-‐02 RRSL_01542 Alkanesulfonates-‐binding protein638721746 7.48 7.18 1.36 up 2.51E-‐01 RRSL_01543 o Alkanesulfonates-‐binding protein638721747 7.93 7.62 1.36 up 3.24E-‐01 RRSL_01544 o Alkanesulfonate monooxygenase( EC:1.14.14.5 )638721749 7.3 7.21 1.17 up 4.25E-‐01 RRSL_01546 o Alkanesulfonates transport ATP-‐binding protein638721751 11.08 10.36 1.81 up 1.92E-‐02 RRSL_01548 o c Hypothetical Protein638721752 9.04 8.41 1.72 up 2.66E-‐02 RRSL_01549 o c Hypothetical protein638721755 9.01 8.38 1.71 up 3.98E-‐02 RRSL_01553 o c Transcriptional regulator cbl638721758 10.04 8.77 2.66 up 9.00E-‐02 RRSL_01556 o Two-‐component sensor histidine kinase( EC:2.7.3.-‐ )638721759 7.98 7.67 1.37 up 2.43E-‐01 RRSL_01557 o Transcriptional regulatory protein638721760 10.03 10.16 1.01 up 9.60E-‐01 RRSL_01558 o c Acetolactate synthase large subunit( EC:2.2.1.6 )638721761 8.11 8.85 1.51 down 3.44E-‐02 RRSL_01560 o c Butirosin biosynthesis protein BtrG638721762 8.44 7.81 1.71 up 2.16E-‐01 RRSL_01561 o Leucine-‐rich repeat family protein638721766 9.4 8.85 1.61 up 3.64E-‐03 RRSL_01565 o c Universal stress protein family638721767 8.59 8.87 1.1 down 2.18E-‐01 RRSL_01566 o c Transcriptional regulators, LysR family638721768 10.83 11 1.01 down 9.52E-‐01 RRSL_01567 o c 2-‐haloalkanoic acid dehalogenase( EC:3.8.1.2 )

638721769 9.98 10.83 1.63 down 7.58E-‐03 RRSL_01568 o c Malate synthase( EC:4.1.3.2 )638721770 11.16 11.84 1.45 down 2.56E-‐02 RRSL_01569 o c Hypothetical Protein638721771 9.01 9.58 1.34 down 8.15E-‐02 RRSL_01570 o c Acyl-‐CoA-‐binding protein homolog638721772 11.07 10.92 1.23 up 5.70E-‐02 RRSL_01571 o c Hypothetical Protein638721773 8.84 9.4 1.34 down 2.38E-‐01 RRSL_01572 o c Ribosomal-‐protein-‐S18-‐alanine acetyltransferase( EC:2.3.1.128 )638721774 10.35 10.56 1.04 down 5.98E-‐01 RRSL_01573 o c Uracil DNA glycosylase superfamily protein638721775 11.67 11.83 1.01 down 8.99E-‐01 RRSL_01574 o c Transporter638721778 13.47 14.08 1.39 down 3.82E-‐01 RRSL_01577 o c Disulfide bond formation protein B638721780 9.16 8.55 1.69 up 4.64E-‐02 RRSL_01581 o c AvrA homolog638721781 7.12 7.16 1.07 up 7.50E-‐01 RRSL_01582 o c Hypothetical Protein638721782 9.52 9.05 1.53 up 3.96E-‐02 RRSL_01583 o c Hypothetical Protein638721783 7.08 7.55 1.25 down 1.83E-‐01 RRSL_01584 o Iron-‐sulfur cluster assembly/repair protein ApbE638721784 8.51 7.77 1.84 up 7.32E-‐02 RRSL_01585 o c Hypothetical Protein638721787 8.4 8.42 1.09 up 6.28E-‐01 RRSL_01589 Hypothetical Protein638721788 9.59 9.47 1.2 up 4.68E-‐01 RRSL_01590 Hypothetical Protein638721790 16.15 16.41 1.08 down 5.10E-‐01 RRSL_01593 Hypothetical Protein638721792 10.13 10.99 1.64 down 6.45E-‐02 RRSL_01595 o c Lysine-‐specific permease638721793 9.96 10.4 1.23 down 2.01E-‐01 RRSL_01596 o c Lysine-‐specific permease638721794 8.99 9.73 1.51 down 8.02E-‐03 RRSL_01597 o c Enoyl-‐CoA hydratase / Delta(3)-‐cis-‐delta(2)-‐trans-‐enoyl-‐CoA isomerase / 3-‐hydroxyacyl-‐CoA dehydrogenase / 3-‐hydroxybutyryl-‐CoA epimerase( EC:1.1.1.35,EC:4.2.1.17,EC:5.1.2.3,EC:5.3.3.8 )638721795 8.28 8.77 1.27 down 9.43E-‐02 RRSL_01598 o c Pyrazinamidase / Nicotinamidase( EC:3.5.1.-‐,EC:3.5.1.19 )638721796 9.25 9.54 1.1 down 6.15E-‐01 RRSL_01599 o c 3-‐ketoacyl-‐CoA thiolase( EC:2.3.1.16 )638721797 8.36 8.53 1.02 down 9.08E-‐01 RRSL_01600 o c Acyl-‐CoA dehydrogenase( EC:1.3.99.-‐ )638721798 8.86 8.68 1.25 up 3.41E-‐01 RRSL_01601 o c Short chain dehydrogenase638721799 8.19 8.95 1.54 down 1.02E-‐02 RRSL_01602 o c Hypothetical cytosolic protein638721800 9.8 10 1.04 down 8.39E-‐01 RRSL_01603 6-‐aminohexanoate-‐dimer hydrolase( EC:3.5.1.46 )638721801 8.15 8.33 1.03 down 9.10E-‐01 RRSL_01604 o c 6-‐aminohexanoate-‐dimer hydrolase( EC:3.5.1.46 )638721802 9.42 10.29 1.66 down 1.12E-‐02 RRSL_01605 o c Hypothetical Protein638721803 10.2 10.71 1.29 down 8.87E-‐02 RRSL_01606 o c Class II Aldolase and Adducin proteins638721804 9.39 9.9 1.3 down 9.77E-‐02 RRSL_01607 o c Glutathione S-‐transferase( EC:2.5.1.18 )638721805 9.07 9.9 1.61 down 2.97E-‐02 RRSL_01608 o c Hypothetical Protein638721806 9.95 10.56 1.38 down 3.86E-‐02 RRSL_01609 o c Epoxide hydrolase( EC:3.3.2.3 )638721807 8.3 8.25 1.15 up 1.64E-‐01 RRSL_01611 o c 1,3-‐propanediol dehydrogenase( EC:1.1.1.202 )638721808 12.55 10.73 3.88 up 1.13E-‐01 RRSL_01610 o c Acetyl-‐hydrolase( EC:3.1.1.-‐ )638721809 8.22 9.17 1.75 down 6.04E-‐04 RRSL_01613 o c Acetyltransferase( EC:2.3.1.-‐ )638721810 10.6 11.2 1.38 down 1.52E-‐02 RRSL_01614 3-‐oxoacyl-‐[acyl-‐carrier protein] reductase( EC:1.1.1.100 )638721811 8.81 9.28 1.25 down 3.28E-‐01 RRSL_01615 o c signal peptide638721812 7.59 8.56 1.77 down 1.59E-‐02 RRSL_01616 o c Hypothetical Protein638721813 10.46 11.47 1.83 down 1.21E-‐02 RRSL_01617 o c Aminomethyltransferase homolog638721814 10.22 9.07 2.45 up 1.66E-‐01 RRSL_01618 o c Hypothetical protein638721815 10.16 10.98 1.6 down 2.03E-‐02 RRSL_01619 o c Thymidylate kinase( EC:2.7.4.9 )638721816 11.96 12.34 1.18 down 1.52E-‐01 RRSL_01620 o c DNA polymerase III, delta subunit( EC:2.7.7.7 )638721817 11.35 12.42 1.91 down 4.25E-‐02 RRSL_02001 o c Hypothetical Protein638721818 10.58 11.23 1.42 down 1.04E-‐01 RRSL_02002 o c Nitrogen regulation protein ntrY( EC:2.7.3.-‐ )638721819 9.98 10.48 1.28 down 4.68E-‐02 RRSL_02003 o c probable signal peptide, proline rich protein638721820 11.34 9.48 4.01 up 6.89E-‐02 RRSL_02004 o c 16S rRNA m(5)C 967 methyltransferase( EC:2.1.1.-‐ )638721821 12.06 13.01 1.75 down 4.04E-‐02 RRSL_02005 o c Heat shock protein HtpX638721822 8.91 8.61 1.36 up 1.87E-‐02 RRSL_02006 o c Hypothetical Protein638721823 8.35 8.64 1.11 down 4.56E-‐01 RRSL_02007 o c Methionyl-‐tRNA formyltransferase( EC:2.1.2.9 )638721824 9.95 9.91 1.13 up 4.67E-‐01 RRSL_02008 o c Hypothetical Protein638721825 12.06 12.46 1.2 down 7.68E-‐02 RRSL_02009 o c Peptide deformylase( EC:3.5.1.88 )638721827 11.1 11.5 1.2 down 2.32E-‐01 RRSL_02011 o c Smf protein638721828 10.69 11.18 1.27 down 1.18E-‐02 RRSL_02012 o c Thiol-‐disulfide isomerase and thioredoxins638721829 11.58 12.31 1.51 down 5.26E-‐02 RRSL_02013 o c DNA topoisomerase I( EC:5.99.1.2 )638721830 9.3 9.33 1.08 up 6.49E-‐01 RRSL_02014 o c Transcriptional regulators, LysR family638721831 10.46 11.08 1.39 down 1.21E-‐01 RRSL_02015 o c AMP-‐(fatty)acid ligases638721832 11.79 11.58 1.28 up 1.11E-‐01 RRSL_02016 o rodA RodA638721833 9.65 9.73 1.04 up 6.74E-‐01 RRSL_02017 o c Cell elongation specific D,D-‐transpeptidase638721834 12.01 11.26 1.85 up 3.38E-‐02 RRSL_02018 o mreD MreD638721835 10.57 10.91 1.15 down 3.44E-‐01 RRSL_02019 o c mreC MreC638721836 12.51 12.69 1.03 down 9.02E-‐01 RRSL_02020 o c mreB MreB638721837 11.8 12.17 1.18 down 4.99E-‐01 RRSL_02021 Hypothetical Protein638721838 12 12.99 1.81 down 8.85E-‐03 RRSL_02022 o c Aspartyl/glutamyl-‐tRNA(Asn/Gln) amidotransferase subunit C( EC:6.3.5.-‐ )638721839 11.48 12.23 1.52 down 5.18E-‐03 RRSL_02023 o c probable Glu-‐tRNA (Gln) amidotransferase subunit A( EC:6.3.5.-‐ )638721840 9.73 10.58 1.63 down 3.37E-‐02 RRSL_02024 o c Hypothetical Protein638721841 7.38 8.3 1.72 down 3.90E-‐02 RRSL_02025 o c Hypothetical Protein638721842 12.41 12.98 1.34 down 6.94E-‐02 RRSL_02026 o c Aspartyl/glutamyl-‐tRNA(Asn/Gln) amidotransferase subunit B( EC:6.3.5.-‐ )638721843 10.54 10.46 1.16 up 3.16E-‐01 RRSL_02028 o c Integrase/recombinase (XerC/CodV family)638721844 9.29 9.83 1.31 down 3.57E-‐02 RRSL_02029 o c Methyltransferase( EC:2.1.1.-‐ )638721845 11.05 11.21 1.01 down 9.46E-‐01 RRSL_02030 o c DnrW638721846 12.42 12.47 1.07 up 7.85E-‐01 RRSL_02031 o c Carboxy-‐cis,cis-‐muconate cyclase( EC:5.5.1.5 )638721847 14.2 13.6 1.66 up 4.54E-‐02 RRSL_02032 Hypothetical Protein638721848 11.32 11.02 1.37 up 5.22E-‐02 RRSL_02032_5 Hypothetical Protein638721849 10.43 11.55 1.96 down 1.95E-‐02 RRSL_02033 o c Ferric uptake regulation protein638721850 11.59 12.3 1.48 down 2.02E-‐02 RRSL_02034 o c Low-‐affinity zinc transport protein638721851 14.32 14.65 1.14 down 3.55E-‐01 RRSL_02035 o c DnaK suppressor protein638721852 10.43 10.84 1.2 down 3.40E-‐01 RRSL_02036 o c Low-‐affinity zinc transport protein

638721853 9.42 8.93 1.56 up 8.31E-‐02 RRSL_02037 o c substrate binding periplasmic protein638721856 10 10.3 1.12 down 4.71E-‐01 RRSL_02040 o Hypothetical Protein638721857 12.48 13.27 1.57 down 1.99E-‐01 RRSL_01389 Bacterial Protein Translation Initiation Factor 2 (IF-‐2)638721858 13.02 13.58 1.35 down 1.90E-‐01 RRSL_01390 o c N utilization substance protein A638721859 14.9 14.79 1.19 up 1.35E-‐01 RRSL_01391 o c Hypothetical cytosolic protein638721860 12.6 13.38 1.55 down 1.45E-‐01 RRSL_01392 o c Ribosomal large subunit pseudouridine synthase B( EC:4.2.1.70 )638721861 11.45 12.19 1.51 down 1.73E-‐01 RRSL_01393 o c scpB ScpB638721862 10.55 9.97 1.65 up 3.94E-‐02 RRSL_01394 o c Hypothetical Protein638721863 13.53 13.24 1.35 up 2.29E-‐02 RRSL_01395 o c Hypothetical Protein638721864 10.75 10.01 1.83 up 5.29E-‐02 RRSL_01396 o c Hypothetical Protein638721872 8.82 8.24 1.65 up 1.34E-‐01 RRSL_01404 o c 2-‐phosphosulfolactate phosphatase( EC:3.1.3.-‐ )638721873 10.32 11.15 1.61 down 2.37E-‐03 RRSL_01405 o c ATPase638721877 7.78 8.3 1.3 down 2.24E-‐01 RRSL_01409 o c Glycerophosphoryl diester phosphodiesterase( EC:3.1.4.46 )638721878 9.55 9.46 1.17 up 1.41E-‐01 RRSL_01410 o c ugpC UgpC638721879 9.83 9.04 1.91 up 1.42E-‐01 RRSL_01411 o c ugpE UgpE638721880 8.88 8.34 1.61 up 2.38E-‐01 RRSL_01412 o c ugpA UgpA638721882 13.29 13.22 1.16 up 1.60E-‐01 RRSL_01413 Hypothetical Protein638721883 10.38 10.34 1.14 up 4.32E-‐01 RRSL_01415 o c Glycerol-‐3-‐phosphate-‐binding protein638721884 9.47 9.21 1.32 up 1.50E-‐01 RRSL_01416 o c Hydrolase (HAD superfamily)638721885 12.99 12.97 1.12 up 5.56E-‐01 RRSL_01417 Hypothetical Protein638721886 10.83 11.43 1.38 down 5.36E-‐02 RRSL_01418 o c Nitrogen regulation protein NR(I)638721887 10.66 11.02 1.17 down 1.86E-‐02 RRSL_01419 o c Nitrogen regulation protein ntrB( EC:2.7.3.-‐ )638721888 13.11 13.76 1.42 down 1.13E-‐01 RRSL_01420 o c Hypothetical Protein638721891 11.18 11.42 1.07 down 7.59E-‐01 RRSL_01423 o c Putative competence-‐damage protein638721892 11.14 11.32 1.03 down 7.55E-‐01 RRSL_01424 o c Hypothetical Protein638721893 11.06 10.66 1.46 up 5.55E-‐03 RRSL_01425 o c C-‐5 sterol desaturase( EC:1.3.-‐ )638721894 10.61 11.4 1.57 down 4.29E-‐02 RRSL_01426 o c Hypothetical Protein638721895 12.82 13.19 1.17 down 1.73E-‐01 RRSL_01427 o c PGRS-‐subfamily of Gly-‐rich proteins638721896 9.66 10.09 1.22 down 3.51E-‐02 RRSL_01428 o c hrpA HrpA638721897 15.11 14.94 1.24 up 1.18E-‐01 RRSL_01355 o c xpsR XpsR638721898 15.01 15.04 1.08 up 6.74E-‐01 RRSL_01356 o c tek Tek638721899 15.53 15.5 1.12 up 5.63E-‐02 RRSL_01357 o c Hypothetical Protein638721900 13.84 13.45 1.45 up 1.11E-‐01 RRSL_01358 o c tek2 Tek2638721901 13.55 12.87 1.77 up 7.05E-‐02 RRSL_01359 o c Integral membrane protein (Rhomboid family)638721902 10.06 10.66 1.37 down 6.71E-‐02 RRSL_01362 DNA helicase638721903 10.94 11.69 1.52 down 7.19E-‐02 RRSL_01363 Predicted hydrolases or acyltransferases638721907 11.71 13.28 2.68 down 1.17E-‐01 RRSL_01367 Bile acid-‐inducible operon protein F638721909 8.4 9.84 2.45 down 5.99E-‐02 RRSL_01369 Acyl-‐CoA dehydrogenase( EC:1.3.99.-‐ )638721910 8.18 8.74 1.33 down 5.46E-‐01 RRSL_01370 Transporter, MFS superfamily638721915 7.63 8.68 1.89 down 1.73E-‐02 RRSL_01376 o tlpA TlpA638721916 9.23 9.81 1.35 down 5.64E-‐02 RRSL_01377 o Chloride channel protein638721918 7.17 7.72 1.32 down 3.25E-‐02 RRSL_01379 Hypothetical Protein638721919 7.36 7.49 1 up 9.84E-‐01 RRSL_01380 o possible Phage replication protein CRI.638721920 7.99 8.41 1.22 down 9.09E-‐02 RRSL_01381 Hypothetical Protein638721921 8.45 8.59 1.01 up 9.85E-‐01 RRSL_01382 Vpf77-‐like protein638721922 8.92 8.03 2.05 up 8.08E-‐02 RRSL_01383 Hypothetical Protein638721923 9.85 8.7 2.45 up 6.72E-‐02 RRSL_01384 Hypothetical Protein638721924 7.3 7.81 1.29 down 9.48E-‐02 RRSL_01385 Possible Zonular occludens toxin (Zot).638721925 13.37 14.1 1.51 down 3.19E-‐02 RRSL_01387 Hypothetical protein638721926 9.83 10.79 1.76 down 4.31E-‐02 RRSL_01388 Hypothetical Protein638721927 16.85 17.08 1.06 down 2.02E-‐01 RRSL_RNA048 5S ( rRNA )638721928 10.22 10.31 1.04 up 7.98E-‐01 RRSL_01963 o c Metal-‐dependent amidase/aminoacylase/carboxypeptidase638721930 11.4 11.56 1.01 down 9.57E-‐01 RRSL_01965 o c dppB DppB638721931 9.55 9.95 1.19 down 2.72E-‐01 RRSL_01966 o c dppC DppC638721932 8.36 9.2 1.62 down 5.05E-‐03 RRSL_01967 o c dppD DppD638721933 9.72 9.84 1.01 up 9.37E-‐01 RRSL_01968 o c hypothetical protein638721934 8.94 9.36 1.21 down 1.50E-‐01 RRSL_01969 Acetylornithine deacetylase( EC:3.5.1.16 )638721939 9.65 10.35 1.47 down 3.54E-‐01 RRSL_01975 o c Transcriptional regulatory protein638721943 10.9 10.04 2.01 up 1.68E-‐01 RRSL_01979 o c Transporter, MFS superfamily638721944 11.13 10.25 2.03 up 1.51E-‐01 RRSL_01980 o c Outer membrane porin protein 32 precursor638721945 10.66 10.61 1.15 up 9.24E-‐02 RRSL_01981 Outer membrane porin protein 32 precursor638721946 10.88 11.17 1.11 down 3.41E-‐01 RRSL_01982 o c 2-‐polyprenyl-‐3-‐methyl-‐6-‐methoxy-‐1,4-‐benzoquinol hydroxylase( EC:1.14.13.-‐ )638721947 12.08 13 1.72 down 9.53E-‐03 RRSL_01983 o c mraZ MraZ638721948 12.59 12.87 1.11 down 3.80E-‐01 RRSL_01984 o c S-‐adenosyl-‐methyltransferase mraW( EC:2.1.1.-‐ )638721949 11.1 11.46 1.16 down 3.72E-‐01 RRSL_01985 o c hypothetical protein638721950 10.31 10.96 1.42 down 3.73E-‐02 RRSL_01986 o c Division specific D,D-‐transpeptidase / Cell division protein ftsI638721951 10.23 10.77 1.32 down 1.28E-‐02 RRSL_01987 o c UDP-‐N-‐acetylmuramoylalanyl-‐D-‐glutamate-‐-‐2, 6-‐diaminopimelate ligase( EC:6.3.2.13 )638721952 11.86 12.3 1.24 down 2.04E-‐01 RRSL_01988 o c UDP-‐N-‐acetylmuramoylalanyl-‐D-‐glutamyl-‐2, 6-‐diaminopimelate-‐-‐D-‐alanyl-‐D-‐alanyl ligase( EC:6.3.2.15 )638721953 12.07 12.61 1.32 down 1.15E-‐01 RRSL_01989 o c Phospho-‐N-‐acetylmuramoyl-‐pentapeptide-‐ transferase( EC:2.7.8.13 )638721955 13.47 13.07 1.45 up 2.27E-‐01 RRSL_01991 o c ftsW FtsW638721956 9.87 10.39 1.3 down 3.90E-‐02 RRSL_01992 o c UDP-‐N-‐acetylglucosamine-‐-‐N-‐acetylmuramyl-‐ (pentapeptide) pyrophosphoryl-‐undecaprenol N-‐acetylglucosamine transferase( EC:2.4.1.227 )638721957 11.97 12.56 1.36 down 5.95E-‐02 RRSL_01993 o c UDP-‐N-‐acetylmuramate-‐-‐alanine ligase( EC:6.3.2.8 )638721958 10.06 10.98 1.71 down 1.63E-‐02 RRSL_01994 o D-‐alanine-‐-‐D-‐alanine ligase( EC:6.3.2.4 )638721959 11.37 11.74 1.17 down 2.39E-‐01 RRSL_01995 o c ftsQ FtsQ638721960 14.53 14.58 1.07 up 4.06E-‐01 RRSL_01996 o c ftsA FtsA638721961 13.97 14.59 1.39 down 2.66E-‐01 RRSL_01997 o c ftsZ FtsZ

638721963 11.84 11.95 1.02 up 8.60E-‐01 RRSL_01999 o c Probable peroxiredoxin638721964 10.29 10.92 1.4 down 1.17E-‐02 RRSL_02000 o c UDP-‐3-‐O-‐[3-‐hydroxymyristoyl] N-‐acetylglucosamine deacetylase( EC:3.5.1.-‐ )638721966 8.06 8.5 1.22 down 3.76E-‐01 RRSL_01116 o c Assimilatory nitrate reductase catalytic subunit( EC:1.7.1.2 )638721972 8.14 7.59 1.61 up 7.12E-‐02 RRSL_01122 o c Isopentenyl transferase (Dimethylallyl transferase)638721974 9.45 9.04 1.46 up 1.43E-‐01 RRSL_01124 o c Luciferase-‐like monooxygenase( EC:1.14.-‐ )638721975 8.48 8.35 1.21 up 3.11E-‐01 RRSL_01125 Hypothetical Protein638721976 8.29 7.45 1.97 up 1.84E-‐01 RRSL_01126 o c Lipoprotein638721977 8.48 8 1.54 up 1.06E-‐01 RRSL_01127 o Hypothetical Protein638721978 11.24 11.07 1.24 up 1.13E-‐01 RRSL_01129 Hypothetical Protein638721979 8.09 7.93 1.23 up 2.59E-‐01 RRSL_01130 o Lactoylglutathione lyase family protein638721980 7.42 7.23 1.26 up 2.63E-‐01 RRSL_01131 o c Hypothetical Protein638721981 7.62 7.76 1 down 9.97E-‐01 RRSL_01132 o Aspartate aminotransferase( EC:2.6.1.1 )638721982 7.63 7.39 1.3 up 5.92E-‐02 RRSL_01133 o Demethylmenaquinone methyltransferase family638721983 7.83 7.88 1.06 up 7.84E-‐01 RRSL_01134 o Demethylmenaquinone methyltransferase family638721984 8.1 8.22 1.01 up 9.40E-‐01 RRSL_01135 o Transcriptional regulators, LysR family638721986 9.5 9.83 1.14 down 2.68E-‐01 RRSL_01137 hypothetical protein638721987 9.34 9.71 1.17 down 4.89E-‐01 RRSL_01138 hypothetical protein638721988 8.47 7.97 1.57 up 1.39E-‐01 RRSL_01139 Possible pyrimidine reductase638721989 8.48 8.94 1.25 down 2.86E-‐01 RRSL_01140 Possible GTP cyclohydrolase II( EC:3.5.4.25 )638721990 9.62 10.17 1.33 down 8.67E-‐02 RRSL_01141 hypothetical protein638721991 8.45 9.38 1.73 down 1.51E-‐02 RRSL_01142 possible transcriptional regulator638721992 8.8 8.28 1.59 up 2.10E-‐02 RRSL_01143 Dihydrodipicolinate synthase( EC:4.2.1.52 )638721993 12.16 10.18 4.35 up 9.79E-‐02 RRSL_01144 Hypothetical Protein638721995 14.57 15.23 1.43 down 3.07E-‐02 RRSL_01323 o c SSU ribosomal protein S2P638721996 11.65 12.42 1.54 down 1.13E-‐01 RRSL_01324 o c Methionine aminopeptidase( EC:3.4.11.18 )638721997 9.09 9.89 1.59 down 1.65E-‐02 RRSL_01325 o c [protein-‐PII] uridylyltransferase( EC:2.7.7.59 )638721998 9.6 10.39 1.57 down 9.42E-‐02 RRSL_01326 o c Ribosomal large subunit pseudouridine synthase F( EC:4.2.1.70 )638721999 10.16 10 1.23 up 3.37E-‐01 RRSL_01327 o c Hypothetical Protein638722000 9.77 10.07 1.12 down 4.99E-‐01 RRSL_01329 o c NAD-‐dependent DNA ligase( EC:6.5.1.2 )638722001 10.5 11.16 1.43 down 3.27E-‐02 RRSL_01330 o c zipA ZipA638722002 11.24 11.44 1.04 down 6.30E-‐01 RRSL_01331 smc Smc638722003 9.87 10.29 1.21 down 4.26E-‐01 RRSL_01332 o c 2-‐hydroxy-‐6-‐oxo-‐6-‐phenylhexa-‐2,4-‐dienoate hydrolase( EC:3.7.1.-‐ )638722004 9.04 9.03 1.11 up 6.96E-‐01 RRSL_01333 o c rarD RarD638722006 13.51 14.01 1.28 down 1.04E-‐01 RRSL_01336 o Hypothetical Protein638722007 11.53 12.25 1.49 down 2.78E-‐02 RRSL_01337 o Hypothetical Protein638722008 10.34 11.28 1.73 down 1.55E-‐03 RRSL_01338 o c Succinyl-‐diaminopimelate desuccinylase( EC:3.5.1.18 )638722009 10.27 11.22 1.75 down 7.08E-‐04 RRSL_01340 o c Ribosomal protein L3P methyltransferase( EC:2.1.1.-‐ )638722010 9.74 10.71 1.78 down 1.89E-‐04 RRSL_01341 Hypothetical Protein638722012 9.61 10.47 1.65 down 3.11E-‐02 RRSL_01343 Acriflavin resistance plasma membrane protein638722017 10.63 11.99 2.32 down 8.75E-‐02 RRSL_01348 o c dppB DppB638722022 9.59 10.27 1.45 down 2.16E-‐02 RRSL_01353 o c ABC transporter ATP-‐binding protein638722023 9.88 10.78 1.69 down 1.15E-‐02 RRSL_01354 o c Predicted acyl-‐CoA transferases/carnitine dehydratase638722024 14.7 14.61 1.17 up 6.73E-‐02 RRSL_01046 o c UDP-‐N-‐acetylglucosamine 4,6-‐dehydratase / UDP-‐D-‐quinovosamine 4-‐dehydrogenase( EC:1.1.1.-‐,EC:4.2.1.-‐ )638722025 10.67 10.8 1.01 up 9.79E-‐01 RRSL_01047 o possible transposase638722026 13.78 14.57 1.57 down 4.68E-‐02 RRSL_01048 o c probable transmembrane protein638722027 12.74 13.63 1.68 down 1.98E-‐01 RRSL_01049 o c UDP-‐bacillosamine synthetase( EC:2.6.1.-‐ )638722028 14.12 14.85 1.5 down 1.29E-‐01 RRSL_01050 o c UDP-‐N-‐acetylbacillosamine 4-‐acetyltransferase( EC:2.3.1.-‐ )638722029 15.79 16.15 1.16 down 4.00E-‐01 RRSL_01051 o c probable glycosyl transferase transmembrane protein638722030 13.62 14.29 1.44 down 1.83E-‐01 RRSL_01053 o c putative acyl transferase protein638722031 13.17 13.89 1.49 down 1.63E-‐01 RRSL_01054 o c Oxidoreductase( EC:1.1.1.-‐ )638722032 13.64 14.33 1.46 down 1.15E-‐01 RRSL_01055 o c Probable maltose O-‐acetyltransferase( EC:2.3.1.79 )638722033 13.52 13.84 1.13 down 5.67E-‐01 RRSL_01056 o c Glycosyltransferase( EC:2.4.1.-‐ )638722034 13.93 14.15 1.06 down 6.78E-‐01 RRSL_01057 o c epsF EpsF638722035 13.25 13.98 1.5 down 1.28E-‐01 RRSL_01058 o c epsE EpsE638722036 14.16 14.87 1.48 down 1.45E-‐01 RRSL_01059 o c espD EspD( EC:1.1.1.-‐ )638722037 14.99 15.3 1.12 down 1.67E-‐01 RRSL_01060 o c epsC EpsC( EC:5.1.3.14 )638722038 14.23 14.92 1.46 down 1.45E-‐01 RRSL_01061 o c epsB EpsB638722039 13.63 14.55 1.72 down 4.96E-‐02 RRSL_01062 o epsP EpsP638722040 15.48 15.83 1.15 down 2.53E-‐01 RRSL_01063 o c epsA EpsA638722041 15.29 15.49 1.05 down 7.37E-‐01 RRSL_01065 Hypothetical Protein638722042 10.98 10.4 1.65 up 4.34E-‐02 RRSL_01066 o c Hypothetical Protein638722043 12.03 11.24 1.91 up 6.76E-‐02 RRSL_01067 o c Transcriptional regulatory protein638722046 11.74 12.29 1.33 down 4.66E-‐01 RRSL_01071 o c AWR family protein638722047 15.06 14.89 1.24 up 2.38E-‐02 RRSL_01072 o c Transmembrane amino acid efflux protein638722048 7.52 7.35 1.24 up 4.81E-‐02 RRSL_01073 ybtQ YbtQ638722050 7.63 7.11 1.58 up 8.37E-‐02 RRSL_01075 o Possible FyuA precursor638722051 8.96 7.88 2.33 up 5.85E-‐02 RRSL_01077 Hypothetical Protein638722052 7.03 7.29 1.09 down 7.84E-‐01 RRSL_01078 o hypothetical protein638722053 9.54 8.76 1.89 up 6.15E-‐02 RRSL_01249 adenine DNA methyltransferase-‐like protein638722054 7.95 7.58 1.42 up 2.07E-‐01 RRSL_01250 Hypothetical Protein638722058 9.15 9.81 1.43 down 9.62E-‐02 RRSL_01255 o c XdhC protein (assists in molybdopterin insertion into xanthine dehydrogenase)638722060 8.9 9.49 1.37 down 2.65E-‐02 RRSL_01257 o c Guanine deaminase( EC:3.5.4.3 )638722061 8.49 8.95 1.25 down 5.40E-‐02 RRSL_01258 o c Integral membrane protein638722062 8.14 7.25 2.05 up 6.99E-‐02 RRSL_01260 o c Hypothetical Protein638722063 10.2 10.01 1.26 up 1.48E-‐01 RRSL_01261 Transcriptional regulators, LysR family638722064 9.26 10.03 1.55 down 1.35E-‐01 RRSL_01262 hypothetical protein

638722065 8.91 9.31 1.2 down 3.79E-‐01 RRSL_01263 o Alcohol dehydrogenase (NADP+)( EC:1.1.1.2,EC:1.1.1.255 )638722066 8.8 8.88 1.04 up 8.76E-‐01 RRSL_01264 Antibiotic biosynthesis monooxygenase638722068 9.58 10.36 1.56 down 1.46E-‐02 RRSL_01266 Hypothetical Protein638722069 8.46 9.29 1.61 down 1.31E-‐03 RRSL_01267 o c Hypothetical membrane spanning protein638722070 9.43 9.86 1.22 down 2.92E-‐01 RRSL_01268 o c Urate oxidase( EC:1.7.3.3 )638722071 13.67 13.24 1.49 up 1.83E-‐01 RRSL_01269 o c Transcriptional regulator, GntR family638722072 7.8 7.92 1.01 up 9.21E-‐01 RRSL_01270 o Xanthine permease638722073 8.84 8.87 1.08 up 6.74E-‐01 RRSL_01271 o Hydroxyatrazine hydrolase( EC:3.5.99.3 )638722074 8.73 8.92 1.03 down 9.02E-‐01 RRSL_01272 o c Chitooligosaccharide deacetylase( EC:3.5.1.-‐ )638722075 9.22 9.61 1.19 down 2.78E-‐01 RRSL_01273 o c Conserved Hypothetical Protein638722076 6.69 7.55 1.65 down 6.01E-‐03 RRSL_01274 Outer membrane porin protein 32 precursor638722077 12.43 13.26 1.61 down 6.09E-‐02 RRSL_01275 Outer membrane porin protein 32 precursor638722079 10.94 11.61 1.44 down 1.97E-‐02 RRSL_01278 o c Hypothetical Protein638722082 12.59 13.6 1.82 down 2.63E-‐01 RRSL_RNA016 ( tRNA )638722083 11.21 11.96 1.52 down 2.62E-‐01 RRSL_01281 o c peptidoglycan binding protein (LysM domain)638722084 10.76 10.56 1.27 up 3.08E-‐02 RRSL_01282 o c Poly(3-‐hydroxyalkanoate) depolymerase( EC:3.1.1.-‐ )638722086 9.65 10.27 1.39 down 1.73E-‐01 RRSL_01284 o c Hypothetical Protein638722087 11.67 11.78 1.02 up 8.63E-‐01 RRSL_01285 o c greB GreB638722090 9.79 9.16 1.7 up 5.73E-‐02 RRSL_01015 o c Hypothetical Protein638722098 10.4 10.68 1.1 down 7.29E-‐01 RRSL_01023 o c Nicotinamide phosphoribosyltransferase( EC:2.4.2.12 )638722099 10.61 11.21 1.37 down 4.34E-‐03 RRSL_01024 o c nicotinamide-‐nucleotide adenylyltransferase / Nudix hydrolase( EC:2.7.7.1 )638722100 10.91 11.41 1.29 down 7.04E-‐02 RRSL_01026 o c pehC PehC( EC:3.2.1.15 )638722102 9.11 8.46 1.74 up 3.46E-‐03 RRSL_01028 o c dTDP-‐glucose 4,6-‐dehydratase( EC:4.2.1.46 )638722103 9.16 8.75 1.46 up 6.42E-‐03 RRSL_01029 o c D-‐galactarate dehydratase( EC:4.2.1.42 )638722106 7.77 7.19 1.65 up 4.83E-‐02 RRSL_01032 o c oxoglutarate semialdehyde dehydrogenase( EC:1.2.1.-‐,EC:1.2.1.4 )638722109 11.08 10.52 1.62 up 2.13E-‐02 RRSL_01035 hypothetical protein638722110 11.27 11.11 1.24 up 8.29E-‐02 RRSL_01036 hypothetical protein638722111 11.29 11.21 1.17 up 3.83E-‐01 RRSL_01037 o c Transcriptional regulators, LysR family638722112 13.13 13.18 1.07 up 2.94E-‐01 RRSL_01038 o Hypothetical Protein638722113 8.85 9.42 1.35 down 1.27E-‐01 RRSL_01040 o Transporter, drug/metabolite exporter family638722114 8.16 8.13 1.12 up 6.63E-‐01 RRSL_01041 o Probable drug efflux lipoprotein638722115 7.56 7.25 1.37 up 2.71E-‐01 RRSL_01042 o Transmembrane drug efflux protein638722116 7.88 7.93 1.07 up 7.49E-‐01 RRSL_01043 o Probable outer membrane drug efflux lipoprotein638722117 7.14 7.28 1.00E+00 RRSL_01044 o Hypothetical Protein638722118 7.82 7.95 1.01 up 9.57E-‐01 RRSL_01045 o Transcriptional regulator, TetR family638722121 9.22 8.54 1.77 up 1.15E-‐02 RRSL_01206 parB ParB638722125 10.2 10.54 1.15 down 2.82E-‐01 RRSL_01210 Hypothetical Protein638722126 11.86 12.12 1.09 down 6.78E-‐01 RRSL_01211 Hypothetical Protein638722128 11.35 12.03 1.45 down 3.48E-‐02 RRSL_01213 o c Serine protease( EC:3.4.21.-‐ )638722129 13.08 14.17 1.93 down 9.80E-‐05 RRSL_01214 o c Hypothetical cytosolic protein638722131 11.49 12.51 1.83 down 3.62E-‐02 RRSL_01216 o c Ornithine carbamoyltransferase( EC:2.1.3.3 )638722132 11.88 11.86 1.12 up 4.81E-‐01 RRSL_01217 o c PhnO protein638722134 11.04 11.69 1.42 down 3.08E-‐02 RRSL_01219 o c Virulence factor mviN homolog638722135 11.59 12.31 1.5 down 6.80E-‐03 RRSL_01220 o c Transcriptional regulator638722136 11.8 12.76 1.76 down 6.19E-‐03 RRSL_01221 o c DedA family protein638722137 12.05 12.9 1.63 down 5.92E-‐03 RRSL_01222 o c Transcriptional regulator, TetR family638722138 9.67 9.04 1.71 up 1.83E-‐01 RRSL_01223 o c Hypothetical Protein638722139 7.79 7.83 1.08 up 8.30E-‐01 RRSL_01224 o c Paraquat-‐inducible protein B638722140 9.16 9.98 1.6 down 3.23E-‐02 RRSL_01225 o c mutL MutL638722141 9.85 10.52 1.44 down 6.02E-‐02 RRSL_01226 o c tRNA delta(2)-‐isopentenylpyrophosphate transferase( EC:2.5.1.8 )638722142 8.13 8.72 1.37 down 1.66E-‐01 RRSL_01227 o c Diamine acetyltransferase( EC:2.3.1.57 )638722143 9.31 9.5 1.03 down 8.60E-‐01 RRSL_01228 o c Hypothetical Protein638722144 9.1 8.53 1.64 up 5.93E-‐02 RRSL_01229 o c AlkB protein638722145 9.56 9.67 1.03 up 8.78E-‐01 RRSL_01230 o c alkB AlkB638722146 8.13 8.26 1 up 9.93E-‐01 RRSL_01231 o c DNA-‐3-‐methyladenine glycosylase II( EC:3.2.2.21 )638722147 7.41 7.81 1.19 down 4.91E-‐01 RRSL_01233 o c Probable ADA regulatory protein of adaptive response / O6-‐methylguanine-‐DNA methyltransferase( EC:2.1.1.63 )638722148 9.11 10.12 1.82 down 4.24E-‐03 RRSL_01234 o c Hypothetical Protein638722150 11.68 11.93 1.07 down 7.82E-‐01 RRSL_01236 o c Hypothetical Protein638722152 12.05 12.99 1.74 down 1.23E-‐02 RRSL_01238 o c Phosphoserine phosphatase( EC:3.1.3.3 )638722154 10.23 11.09 1.65 down 3.86E-‐02 RRSL_01240 o c 2-‐amino-‐4-‐hydroxy-‐6-‐ hydroxymethyldihydropteridine pyrophosphokinase( EC:2.7.6.3 )638722155 9.3 10.18 1.68 down 2.09E-‐02 RRSL_01241 o c Deoxyguanosine kinase( EC:2.7.1.113 )638722156 11.42 12.17 1.52 down 1.47E-‐02 RRSL_01242 o c 3-‐methyl-‐2-‐oxobutanoate hydroxymethyltransferase( EC:2.1.2.11 )638722157 10.73 11.12 1.18 down 5.85E-‐01 RRSL_01243 o c Hypothetical Protein638722158 8.63 9.47 1.62 down 7.37E-‐03 RRSL_01244 o c Transporter638722159 8.5 9.12 1.39 down 2.59E-‐02 RRSL_01245 o c Para-‐aminobenzoate synthetase component I /4-‐amino-‐4-‐deoxychorismate lyase( EC:4.-‐,EC:4.1.3.-‐ )638722162 8.64 8.57 1.16 up 3.83E-‐01 RRSL_01490 Dibenzothiophene desulfurization enzyme C638722163 7.94 7.78 1.23 up 2.55E-‐01 RRSL_01491 o TauD / TfdA family dioxygenase638722164 11.41 11.54 1 up 9.83E-‐01 RRSL_01492 o Hypothetical Protein638722165 9.74 10.07 1.14 down 4.50E-‐01 RRSL_01493 o c ABC type uncharacterized transport system permease component638722166 11.66 10.86 1.91 up 6.75E-‐04 RRSL_01495 o c Hypothetical Protein638722168 13.37 13.99 1.39 down 4.53E-‐02 RRSL_01497 o c Hypothetical Protein638722169 12.69 13.66 1.78 down 5.97E-‐02 RRSL_01498 o c ElaB protein638722170 14.13 13.98 1.22 up 1.96E-‐01 RRSL_01499 o Peroxiredoxin( EC:1.11.1.7 )638722171 8.13 7.77 1.42 up 2.78E-‐01 RRSL_01500 o c Guanine-‐hypoxanthine permease638722172 9.32 8.77 1.61 up 1.67E-‐01 RRSL_01501 Hypothetical Protein638722173 8.03 8.38 1.16 down 2.37E-‐01 RRSL_01502 o c Glutaryl-‐CoA dehydrogenase( EC:1.3.99.7 )

638722174 7.71 7.65 1.15 up 5.03E-‐01 RRSL_01503 o c Transcriptional regulator, IclR family638722177 11.21 7.93 10.67 up 7.25E-‐02 RRSL_01507 o c Metal-‐dependent hydrolase638722178 9.91 8.75 2.47 up 1.04E-‐01 RRSL_01506 o c Hypothetical Protein638722180 10.52 10.64 1.01 up 9.70E-‐01 RRSL_01509 o c FMN reductase( EC:1.5.1.29 )638722181 10.76 10.51 1.31 up 6.51E-‐02 RRSL_01510 o c Peptide methionine sulfoxide reductase msrA( EC:1.8.4.6 )638722182 9.23 9.24 1.09 up 4.91E-‐01 RRSL_01511 o c Hypothetical Protein638722183 12.78 12.67 1.19 up 2.42E-‐01 RRSL_01512 o c Cyclopropane-‐fatty-‐acyl-‐phospholipid synthase( EC:2.1.1.79 )638722184 10.67 10.86 1.03 down 8.59E-‐01 RRSL_01513 o c Pyridoxamine 5'-‐phosphate oxidase( EC:1.4.3.5 )638722187 10.36 10.52 1.01 down 9.25E-‐01 RRSL_01516 o possible oxidoreductase transmembrane dehydrogenase638722188 10.9 10.38 1.58 up 2.98E-‐02 RRSL_01517 o dehydrogluconate dehydrogenase, large subunit( EC:1.1.99.4 )638722189 9.14 9.16 1.08 up 6.59E-‐01 RRSL_01518 o dehydrogluconate dehydrogenase, cytochrome c subunit( EC:1.1.99.4 )638722190 9.52 10.61 1.93 down 2.87E-‐03 RRSL_01519 o c probable transmembrane638722191 8.77 9.67 1.68 down 3.33E-‐02 RRSL_01520 o c Molybdopterin biosynthesis MoeB protein638722192 11.09 11.52 1.23 down 2.84E-‐01 RRSL_01521 o c peroxidase / catalase( EC:1.11.1.6,EC:1.11.1.7 )638722194 9.25 9.99 1.51 down 1.85E-‐02 RRSL_01523 o c Thioredoxin638722195 12.51 11.99 1.58 up 5.01E-‐01 RRSL_01524 o c Thioredoxin638722196 10.51 8.68 3.92 up 7.30E-‐02 RRSL_01525 o c Long-‐chain-‐fatty-‐acid-‐-‐CoA ligase( EC:6.2.1.3 )638722197 9.72 9.33 1.45 up 7.74E-‐02 RRSL_01526 o c ankyrin repeat harboring protein638722198 11.05 11.04 1.11 up 2.79E-‐01 RRSL_01527 o c chaC ChaC638722199 13.62 13.36 1.32 up 2.32E-‐01 RRSL_RNA019 ( tRNA )638722200 11.48 12.21 1.51 down 1.08E-‐02 RRSL_01528 o c Peptidyl-‐prolyl cis-‐trans isomerase( EC:5.2.1.8 )638722201 11.41 12.49 1.91 down 1.68E-‐03 RRSL_01529 o c Cellulose synthase operon C protein638722202 8.29 8.13 1.23 up 5.92E-‐01 RRSL_01530 Hypothetical Protein638722203 15.48 15.56 1.04 up 7.93E-‐01 RRSL_01286 Hypothetical Protein638722204 9.85 9.62 1.29 up 4.30E-‐02 RRSL_01287 Hypothetical Protein638722205 8.4 8.36 1.13 up 5.36E-‐01 RRSL_01288 o livF LivF638722206 9.03 9.12 1.04 up 7.47E-‐01 RRSL_01289 o livG LivG638722207 10.07 10.15 1.04 up 6.77E-‐01 RRSL_01290 o c livM LivM638722208 9.9 8.83 2.31 up 5.05E-‐02 RRSL_01291 o c livH LivH638722210 9.96 10.04 1.04 up 5.22E-‐01 RRSL_01293 o c Medium-‐chain-‐fatty-‐acid-‐-‐CoA ligase( EC:6.2.1.-‐ )638722211 9.21 10.06 1.64 down 2.66E-‐02 RRSL_01294 o c Hypothetical cytosolic protein638722212 11.07 11.89 1.59 down 2.66E-‐03 RRSL_01295 o c Peptide methionine sulfoxide reductase msrB( EC:1.8.4.6 )638722213 12.88 13.57 1.46 down 3.05E-‐03 RRSL_01296 o c Intracellular septation protein638722214 15.03 16.04 1.82 down 2.35E-‐02 RRSL_01297 o c Signal Peptide isomerase rotamase638722215 9.48 10.29 1.59 down 4.68E-‐02 RRSL_01298 o c ABC transporter substrate-‐binding protein638722216 9.53 10.58 1.87 down 8.90E-‐03 RRSL_01299 o c Hypothetical Protein638722217 9.2 10.09 1.68 down 2.18E-‐03 RRSL_01300 o c ABC transporter ATP-‐binding protein638722218 9 9.57 1.34 down 4.22E-‐01 RRSL_01301 o c Outer membrane porin protein 32 precursor638722219 8.39 8.23 1.23 up 8.44E-‐02 RRSL_01302 o c Two component system histidine kinase( EC:2.7.3.-‐ )638722223 9.18 8.29 2.04 up 6.86E-‐02 RRSL_01308 o c Short-‐chain type dehydrogenase/reductase( EC:1.-‐ )638722224 10.34 10.35 1.09 up 6.80E-‐01 RRSL_01309 o Transcriptional regulators, LysR family638722225 13.34 12.79 1.62 up 1.41E-‐01 RRSL_01310 o c Hypothetical Protein638722226 16.73 16.31 1.48 up 2.64E-‐03 RRSL_01311 o c Hypothetical Protein638722229 11.56 12.54 1.78 down 8.17E-‐02 RRSL_01314 o c Phosphoribosylformylglycinamidine synthase( EC:6.3.5.3 )638722230 12.13 12.57 1.23 down 5.74E-‐02 RRSL_01316 o c Hypothetical protein638722231 7.8 8.72 1.71 down 3.02E-‐03 RRSL_01315 o Nitric-‐oxide reductase subunit C( EC:1.7.99.7 )638722232 9.78 10.72 1.74 down 4.29E-‐02 RRSL_01317 o c Glucose-‐6-‐phosphate isomerase / Glucose-‐6 phosphate 1-‐epimerase( EC:5.1.3.15,EC:5.3.1.9 )638722233 11.1 11.48 1.18 down 1.21E-‐01 RRSL_01319 o c ABC transporter ATP-‐binding protein638722234 9.04 9.58 1.31 down 8.86E-‐02 RRSL_01318 o c Acyl-‐CoA thioesterase I / Lysophospholipase( EC:3.1.1.5,EC:3.1.2.-‐ )638722236 9.17 10.03 1.65 down 7.82E-‐03 RRSL_01450 o c Exodeoxyribonuclease VII large subunit( EC:3.1.11.6 )638722238 9.21 8.86 1.41 up 1.28E-‐01 RRSL_01452 Acetoacetyl-‐CoA reductase( EC:1.1.1.36 )638722239 9 8.78 1.29 up 3.59E-‐01 RRSL_01453 o c Hypothetical Protein638722240 9.83 9.87 1.08 up 4.46E-‐01 RRSL_01454 o c Hypothetical cytosolic protein638722241 9.06 8.7 1.42 up 2.51E-‐01 RRSL_01455 Citrate-‐proton symporter638722242 11.61 10.98 1.7 up 1.56E-‐01 RRSL_01456 Citrate-‐proton symporter638722243 8.86 9.07 1.05 down 5.98E-‐01 RRSL_01457 o c hypothetical protein638722244 10.06 9.7 1.42 up 1.51E-‐01 RRSL_01458 o c D-‐beta-‐hydroxybutyrate permease638722245 11.41 12.36 1.75 down 2.56E-‐03 RRSL_01459 Hypothetical Protein638722246 9.68 9.79 1.02 up 9.42E-‐01 RRSL_01460 o c possible transmembrane conserved hypothetical protein638722247 7.89 7.53 1.41 up 1.59E-‐02 RRSL_01461 o c Transporter638722248 9.31 8.19 2.4 up 9.54E-‐02 RRSL_01462 Hypothetical Protein638722249 13.38 14.13 1.53 down 2.04E-‐01 RRSL_01463 o c Hypothetical Protein638722250 9.63 9.58 1.14 up 1.42E-‐01 RRSL_01464 o c Hypothetical Protein638722251 10.17 10.73 1.34 down 1.48E-‐02 RRSL_01465 o c Cyclohexadienyl dehydratase precursor( EC:4.2.1.51 )638722252 12.33 12.33 1.11 up 3.25E-‐01 RRSL_01466 o c C4-‐dicarboxylate-‐binding protein638722253 15.52 15.7 1.02 down 7.24E-‐01 RRSL_01467 o c Hypothetical Protein638722254 9.98 10.19 1.05 down 7.66E-‐01 RRSL_01468 Hypothetical Protein638722255 10.37 9.87 1.56 up 2.09E-‐01 RRSL_01469 o c Transporter, drug/metabolite exporter family638722256 7.15 7.34 1.03 down 9.31E-‐01 RRSL_01470 Hypothetical Protein638722257 7.88 7.47 1.47 up 1.80E-‐01 RRSL_01471 o ADA regulatory protein / O6-‐methylguanine-‐DNA methyltransferase( EC:2.1.1.63 )638722258 8 7.67 1.38 up 1.43E-‐01 RRSL_01472 ADA regulatory protein / O6-‐methylguanine-‐DNA methyltransferase( EC:2.1.1.63 )638722259 8.47 8.78 1.13 down 6.02E-‐01 RRSL_01473 o c Hypothetical Protein638722260 12.35 11.69 1.74 up 1.28E-‐01 RRSL_01474 o c Neutral zinc metallopeptidase family638722262 9.45 9.87 1.21 down 2.96E-‐01 RRSL_01476 Hypothetical Protein638722263 8.61 8.9 1.11 down 4.41E-‐01 RRSL_01477 o putative gamma-‐glutamyltranspeptidase( EC:2.3.2.2 )638722267 9.34 9.34 1.1 up 6.77E-‐01 RRSL_01479 o Transcriptional regulators, LysR family

638722268 8.33 9 1.44 down 4.76E-‐02 RRSL_01481 o c Transcriptional regulators, LysR family638722269 10.82 11.08 1.08 down 4.92E-‐01 RRSL_01482 o glycoprotein/polysaccharide metabolism638722270 11.03 11.99 1.76 down 1.77E-‐03 RRSL_01483 o c Metal-‐dependent hydrolase( EC:3.-‐ )638722271 8.09 8.98 1.69 down 7.95E-‐03 RRSL_01485 o c Calcineurin-‐like phosphoesterase638722272 16.69 16.94 1.08 down 6.65E-‐02 RRSL_01486 o c hypothetical signal peptide protein638722274 10.75 11.61 1.64 down 6.92E-‐03 RRSL_01080 o c Arogenate dehydrogenase / Prephenate dehydrogenase( EC:1.3.1.12,EC:1.3.1.43 )638722275 8.57 9.51 1.74 down 3.63E-‐02 RRSL_01081 o c Hypothetical Protein638722276 12.32 12.75 1.23 down 1.75E-‐01 RRSL_01082 o c chorismate mutase / prephenate dehydratase( EC:4.2.1.51,EC:5.4.99.5 )638722277 11.45 12.36 1.69 down 6.45E-‐02 RRSL_01083 o c Phosphoserine aminotransferase( EC:2.6.1.52 )638722278 15.3 15.97 1.44 down 1.11E-‐02 RRSL_01084 o c Hypothetical Protein638722279 14.18 14.73 1.33 down 3.86E-‐02 RRSL_01085 o c DNA gyrase subunit A( EC:5.99.1.3 )638722280 16.48 16.78 1.12 down 1.40E-‐01 RRSL_01086 o c Outer membrane protein638722281 13.69 13.79 1.03 up 8.91E-‐01 RRSL_01087 o c Hypothetical Protein638722282 11.93 12.98 1.87 down 7.10E-‐03 RRSL_01088 o c 3-‐demethylubiquinone 3-‐methyltransferase( EC:2.1.1.64 )638722283 10.15 10.43 1.1 down 4.17E-‐01 RRSL_01090 o c probable transmembrane638722284 9.54 10.25 1.49 down 5.68E-‐03 RRSL_01091 o Transcriptional regulator, ArsR family638722285 9.28 10.27 1.79 down 3.03E-‐03 RRSL_01092 o Hypothetical Protein638722286 8.36 8.69 1.14 down 3.63E-‐01 RRSL_01093 o Transcriptional regulators, LysR family638722287 7.55 7.78 1.07 down 8.19E-‐01 RRSL_01094 o Oxidoreductase( EC:1.1.1.-‐ )638722288 8.26 8.46 1.04 down 8.55E-‐01 RRSL_01095 o NADH:flavin oxidoreductases, Old Yellow Enzyme family638722289 8 8.26 1.09 down 7.21E-‐01 RRSL_01096 o Pirin638722290 8.07 8.42 1.16 down 4.06E-‐01 RRSL_01097 Shikimate kinase( EC:2.7.1.71 )638722292 8.75 9.49 1.51 down 1.55E-‐01 RRSL_01100 o c UDP-‐N-‐acetylenolpyruvoylglucosamine reductase( EC:1.1.1.158 )638722293 11.37 12.24 1.66 down 2.00E-‐02 RRSL_01101 o c yajQ YajQ638722294 12.16 12.75 1.36 down 5.16E-‐02 RRSL_01102 o c Hypothetical membrane spanning protein638722295 8.64 8.85 1.05 down 7.98E-‐01 RRSL_01103 o c Regulatory protein638722296 8.85 9.72 1.66 down 1.49E-‐02 RRSL_01104 o c Integrase/recombinase (XerD/RipX family)638722297 10.61 10.53 1.17 up 2.02E-‐01 RRSL_01106 o c Hypothetical Protein638722298 10.04 10.23 1.04 down 8.60E-‐01 RRSL_01109 o iron-‐sulfur cluster-‐binding protein638722300 8.86 8.72 1.22 up 1.78E-‐01 RRSL_01111 o c Transporter, Sodium/bile acid symporter family638722301 8.1 8.18 1.04 up 8.33E-‐01 RRSL_01112 o c Transcriptional regulatory protein638722302 9.15 9.33 1.03 down 8.64E-‐01 RRSL_01113 Hypothetical Protein638722303 13.13 13.29 1.02 down 7.81E-‐01 RRSL_00918 Predicted metal-‐dependent hydrolase638722306 7.72 7.95 1.06 down 7.99E-‐01 RRSL_00922 o Membrane-‐bound aldehyde dehydrogenase, large subunit( EC:1.2.99.3 )638722307 6.43 7.02 1.36 down 1.49E-‐01 RRSL_00923 o Membrane-‐bound aldehyde dehydrogenase iron-‐sulfur protein( EC:1.2.99.3 )638722310 11.84 11.59 1.31 up 1.54E-‐01 RRSL_00927 Hypothetical Protein638722311 9.31 9.9 1.37 down 1.67E-‐02 RRSL_00928 o 2-‐isopropylmalate synthase( EC:4.1.3.12 )638722312 10.17 9.96 1.27 up 3.82E-‐01 RRSL_00929 o Cadmium resistance regulatory protein638722313 8.21 9.04 1.61 down 1.12E-‐01 RRSL_00930 o Lead, cadmium, zinc and mercury transporting ATPase( EC:3.6.3.-‐ )638722315 8.66 9.06 1.2 down 3.07E-‐01 RRSL_00932 o c Universal stress protein family638722316 9.23 9.44 1.05 down 5.16E-‐01 RRSL_00933 o c Hypothetical Protein638722317 9.18 9.45 1.09 down 7.21E-‐01 RRSL_00934 o c Nitropropane dioxygenase / Trans-‐enoyl-‐CoA reductase family638722318 8.71 8.79 1.04 up 7.10E-‐01 RRSL_00935 o Sensor protein baeS( EC:2.7.3.-‐ )638722319 9.16 9.55 1.19 down 3.25E-‐01 RRSL_00936 o Transcriptional regulator, two component response regulator638722321 8.75 9.76 1.81 down 3.80E-‐02 RRSL_00938 o mexD MexD638722322 7.72 8.81 1.94 down 8.43E-‐04 RRSL_00939 o Type I secretion outer membrane protein638722323 9.76 10.59 1.62 down 2.67E-‐02 RRSL_00940 o Macrolide-‐efflux protein638722325 13.4 13.83 1.23 down 3.29E-‐01 RRSL_00942 o c Transcriptional repressor PadR638722326 9.56 10.23 1.45 down 1.01E-‐01 RRSL_00943 o Transcriptional regulators, LysR family638722327 9.62 10.52 1.69 down 1.80E-‐02 RRSL_00944 o c Nitropropane dioxygenase / Trans-‐enoyl-‐CoA reductase family638722328 10.19 8.12 4.61 up 7.08E-‐02 RRSL_00945 o c Hypothetical Protein638722329 6.7 7.28 1.36 down 3.43E-‐02 RRSL_00946 o c Hypothetical Protein638722331 8.96 8.44 1.58 up 3.29E-‐02 RRSL_00948 o c Probable transmembrane methyl-‐accepting chemotaxis protein638722332 9.23 9.8 1.35 down 1.67E-‐01 RRSL_00949 o c Acetyltransferase( EC:2.3.1.-‐ )638722333 10.07 10.79 1.49 down 2.75E-‐01 RRSL_00950 o Hypothetical Protein638722334 16.02 15.42 1.66 up 1.23E-‐03 RRSL_00810 o c Cold shock protein638722336 8.66 8.42 1.3 up 3.22E-‐01 RRSL_00812 o c Hypothetical Protein638722337 7.92 8.56 1.41 down 5.44E-‐02 RRSL_00813 o c FdhD protein (fdsC)638722338 8.52 9.62 1.94 down 2.42E-‐02 RRSL_00814 o c Hypothetical Protein638722341 8.2 7.41 1.9 up 1.73E-‐01 RRSL_00818 Hypothetical Protein638722343 9.01 8.5 1.57 up 1.25E-‐01 RRSL_00820 o c Hypothetical Protein638722344 9.06 9.81 1.52 down 1.54E-‐02 RRSL_00821 Acriflavin resistance plasma membrane protein638722345 9.22 9.79 1.35 down 3.51E-‐03 RRSL_00822 Acriflavin resistance plasma membrane protein638722346 9.15 9.89 1.52 down 2.20E-‐02 RRSL_00823 Hypothetical Protein638722347 11.09 11.73 1.42 down 1.10E-‐02 RRSL_00824 Possible Outer Membrane Efflux Pump638722348 7.96 8.74 1.55 down 8.33E-‐03 RRSL_00825 o c Hypothetical Protein638722349 9.68 8.81 2.02 up 7.62E-‐02 RRSL_00826 o c Hypothetical protein638722350 9.25 8.87 1.43 up 6.06E-‐02 RRSL_00827 o c Hypothetical Protein638722351 9.64 9.99 1.16 down 3.22E-‐01 RRSL_00828 o c Hypothetical protein638722352 10.67 10.69 1.09 up 7.96E-‐01 RRSL_00829 o c Hypothetical protein638722353 14.09 14.08 1.1 up 2.71E-‐01 RRSL_00830 o c Hypothetical Protein638722354 8.76 8.95 1.04 down 8.12E-‐01 RRSL_00831 Possible transcriptional regulators, LysR family638722355 9.35 10.03 1.45 down 5.00E-‐02 RRSL_00832 o c Hypothetical cytosolic protein638722357 9.47 10.38 1.7 down 1.37E-‐02 RRSL_00834 Hypothetical protein638722358 10.17 10.19 1.09 up 5.70E-‐01 RRSL_00835 Probable transglutaminase-‐like enzymes, putative cysteine proteases638722359 9.99 9.53 1.52 up 9.99E-‐02 RRSL_00835_1 Possible hydrolase (HAD superfamily)

638722360 8.55 8.2 1.41 up 1.18E-‐02 RRSL_00836 Possible Metal dependent amidase/aminoacylase/carboxypeptidase638722363 12.79 11.87 2.08 up 1.20E-‐01 RRSL_00840 Hypothetical Protein638722364 9.28 9.36 1.04 up 8.61E-‐01 RRSL_00951 MobA-‐like protein638722365 10.67 10.41 1.32 up 1.68E-‐01 RRSL_00952 Hypothetical Protein638722366 12.8 12.17 1.71 up 1.09E-‐02 RRSL_00958 Hypothetical protein638722367 12.3 11.88 1.48 up 3.72E-‐02 RRSL_00959 ATPase, AAA family638722368 9.78 10.51 1.5 down 1.44E-‐01 RRSL_00960 ATPase, AAA family638722369 9.23 10.19 1.76 down 8.89E-‐02 RRSL_00961 o Hypothetical Protein638722370 11.71 12.19 1.26 down 2.85E-‐01 RRSL_00962 o c Outer-‐membrane lipoproteins carrier protein638722371 9.48 10 1.3 down 1.34E-‐01 RRSL_00963 o c ftsK FtsK638722372 11.8 12.94 1.99 down 1.32E-‐03 RRSL_00964 o c Thioredoxin reductase( EC:1.8.1.9 )638722373 10.22 10.69 1.25 down 4.65E-‐02 RRSL_00965 o c SMR/MUTS family protein638722374 11.3 11.64 1.14 down 1.27E-‐01 RRSL_00966 o c Hypothetical Protein638722375 13.03 13.18 1.01 down 9.50E-‐01 RRSL_00967 o c Hypothetical Protein638722376 12.88 12.71 1.24 up 2.02E-‐01 RRSL_00968 o c Hypothetical Protein638722377 12.25 12.13 1.2 up 2.38E-‐02 RRSL_00969 o c Glutamine-‐dependent NAD(+) synthetase( EC:6.3.5.1 )638722378 10.29 10.53 1.07 down 4.35E-‐01 RRSL_00970 o c Hypothetical cytosolic protein638722380 10.37 10.76 1.19 down 1.40E-‐01 RRSL_00972 o c Aldehyde dehydrogenase( EC:1.2.1.3 )638722381 8.95 9.07 1.02 up 9.06E-‐01 RRSL_00973 o c Hypothetical Protein638722384 10.09 10.54 1.25 down 8.23E-‐02 RRSL_00976 o c HemY protein638722388 9.88 9.81 1.15 up 6.11E-‐01 RRSL_00766 o Transcriptional regulators, LysR family638722389 7.66 8.2 1.31 down 1.05E-‐01 RRSL_00767 o esterase( EC:3.1.-‐ )638722390 9.39 9.95 1.33 down 7.29E-‐02 RRSL_00768 o NAD(P)H-‐dependent quinone reductase( EC:1.-‐ )638722391 10.04 10.25 1.04 down 7.87E-‐01 RRSL_00769 Hypothetical protein638722395 8.12 7.96 1.24 up 2.62E-‐01 RRSL_00773 o Cell surface protein638722396 8.32 7.77 1.63 up 3.61E-‐01 RRSL_00774 o Co-‐activator of prophage gene expression IbrA638722397 8.93 8.61 1.38 up 1.31E-‐01 RRSL_00775 o Co-‐activator of prophage gene expression IbrB638722398 7.41 8.15 1.51 down 3.69E-‐02 RRSL_00776 o c Transcriptional regulator, LacI family638722399 7.93 7.29 1.71 up 2.54E-‐02 RRSL_00777 o c Galactarate/altronate dehydratase family protein638722400 11.57 10.82 1.86 up 5.11E-‐02 RRSL_00778 o c Glucarate/galactarate transporter638722401 9.39 10.08 1.46 down 2.99E-‐02 RRSL_00779 o c 2,4-‐dihydroxyhept-‐2-‐ene-‐1,7-‐dioic acid aldolase( EC:4.1.2.-‐,EC:4.1.2.20 )638722402 9.17 8.9 1.34 up 2.54E-‐02 RRSL_00780 o c Tartrate dehydrogenase( EC:1.1.1.93 )638722403 8.2 8.45 1.08 down 6.30E-‐01 RRSL_00781 o c Succinate-‐semialdehyde dehydrogenase (NADP+)( EC:1.2.1.16 )638722411 10.94 10.46 1.54 up 5.13E-‐03 RRSL_00683 o c Hypothetical Protein638722412 10.33 10.56 1.06 down 5.95E-‐01 RRSL_00684 o c Aldehyde dehydrogenase( EC:1.2.1.3 )638722413 9.44 9.99 1.33 down 1.01E-‐01 RRSL_00685 o c Hypothetical Protein638722414 8.35 8.18 1.24 up 2.10E-‐01 RRSL_00686 o c Glucoamylase( EC:3.2.1.3 )638722415 10.1 10.42 1.13 down 4.54E-‐01 RRSL_00687 o Hypothetical protein638722420 8.16 7.68 1.53 up 3.10E-‐02 RRSL_00693 o c CoxE protein638722422 8 7.33 1.76 up 1.18E-‐02 RRSL_00695 o c Carbon monoxide oxygenase (cytochrome b-‐561) medium subunit( EC:1.2.2.4 )638722427 10.62 10.78 1.01 down 9.31E-‐01 RRSL_00700 o c CreA protein638722428 8.28 9.32 1.86 down 1.83E-‐02 RRSL_00701 o c Transcriptional regulators, LysR family638722429 9.62 8.84 1.9 up 1.22E-‐01 RRSL_00702 o c Probable transmembrane multi-‐drug resistance -‐like protein, MFS family638722430 8.49 7.66 1.96 up 5.12E-‐02 RRSL_00703 Hypothetical protein638722431 8.74 8.31 1.48 up 2.55E-‐01 RRSL_00704 o Hypothetical Protein638722434 10.62 10.34 1.34 up 1.76E-‐01 RRSL_00707 Probable transcriptional regulator, MarR family638722435 10.59 10.62 1.08 up 8.45E-‐01 RRSL_00711 Transcriptional regulators, LysR family638722436 10.02 7.95 4.62 up 8.29E-‐02 RRSL_00712 Muconate cycloisomerase( EC:5.5.1.1 )638722437 8.04 8.02 1.12 up 8.06E-‐01 RRSL_00713 Muconolactone delta-‐isomerase( EC:5.3.3.4 )638722439 12.18 12.12 1.15 up 2.60E-‐01 RRSL_00886 Hypothetical Protein638722440 11.59 12.28 1.46 down 1.18E-‐01 RRSL_00887 Hypothetical Protein638722441 14.43 14.47 1.08 up 4.05E-‐01 RRSL_00888 putative cytochrome P450638722442 8.43 8.46 1.08 up 8.29E-‐01 RRSL_00889 Hypothetical Protein638722443 7.38 8.01 1.4 down 5.15E-‐02 RRSL_00890 o Transposase638722444 10.85 10.93 1.04 up 7.54E-‐01 RRSL_00891 o c Hypothetical Protein638722445 9.05 9.36 1.12 down 6.47E-‐01 RRSL_00892 o Transporter638722446 8.31 8.42 1.02 up 8.38E-‐01 RRSL_00894 o Transcriptional regulators, LysR family638722447 8.33 8.76 1.22 down 5.22E-‐01 RRSL_00895 o 4-‐hydroxybenzoate transporter638722448 9.32 9.75 1.22 down 2.61E-‐01 RRSL_00896 o nahR NahR638722449 8.37 9.45 1.92 down 9.87E-‐03 RRSL_00897 o Ferredoxin-‐-‐NAD(+) reductase( EC:1.18.1.3 )638722450 10.41 11.03 1.39 down 2.36E-‐01 RRSL_00898 o Salicylate-‐5-‐hydroxylase large oxygenase component( EC:1.14.15.-‐ )638722451 10.11 11.01 1.69 down 9.62E-‐02 RRSL_00899 o Hypothetical Protein638722452 9.56 10.52 1.77 down 3.15E-‐02 RRSL_00900 o Rieske-‐type ferredoxin638722453 9.91 10.86 1.76 down 2.40E-‐03 RRSL_00901 o Gentisate 1,2-‐dioxygenase( EC:1.13.11.4 )638722455 8.34 8.51 1.02 down 8.32E-‐01 RRSL_00904 o Outer membrane porin protein 32 precursor638722461 11.5 10.98 1.58 up 1.21E-‐01 RRSL_00912 o c Transglycosylase associated protein638722462 11.42 10.86 1.62 up 2.40E-‐02 RRSL_00913 o c Transcriptional regulatory protein638722463 8.46 8.91 1.24 down 5.60E-‐02 RRSL_00915 o c Phosphate regulon sensor protein phoR( EC:2.7.3.-‐ )638722464 9.95 10.62 1.44 down 1.88E-‐01 RRSL_00916 o c Hypothetical Protein638722465 13.34 13.65 1.12 down 5.07E-‐01 RRSL_00917 o c Transcriptional regulatory protein638722466 13.75 13.98 1.07 down 8.45E-‐01 RRSL_RNA015 ( tRNA )638722467 13.59 13.78 1.03 down 9.16E-‐01 RRSL_RNA014 ( tRNA )638722468 13.34 13.45 1.03 up 9.32E-‐01 RRSL_RNA013 ( tRNA )638722469 16.85 17.04 1.03 down 2.24E-‐01 RRSL_RNA044 16S ( rRNA )638722472 16.85 17.02 1.02 down 4.17E-‐01 RRSL_RNA046 23S ( rRNA )638722473 16.88 17.08 1.04 down 9.28E-‐02 RRSL_RNA047 5S ( rRNA )

638722474 13.8 14.01 1.05 down 7.84E-‐01 RRSL_01429 Isrso10638722476 10.15 9.8 1.41 up 1.45E-‐01 RRSL_01431 RTX family calcium-‐binding cytotoxins and bacteriocins638722477 9.88 9.98 1.03 up 8.95E-‐01 RRSL_01432 RTX family calcium-‐binding cytotoxins and bacteriocins638722478 8.82 9.94 1.97 down 3.07E-‐02 RRSL_01433 o c phzF PhzF638722479 7.12 8.07 1.75 down 1.39E-‐02 RRSL_01434 Acetyltransferase( EC:2.3.1.-‐ )638722480 7.96 8.15 1.03 down 9.19E-‐01 RRSL_01435 Hypothetical Protein638722481 10.11 10.57 1.25 down 2.37E-‐01 RRSL_01436 o Phosphatidylserine decarboxylase( EC:4.1.1.65 )638722482 8.94 9.3 1.17 down 3.92E-‐01 RRSL_01437 o c Nitropropane dioxygenase / Trans-‐enoyl-‐CoA reductase family638722483 8.61 8.85 1.07 down 4.33E-‐01 RRSL_01438 o c Haloacetate dehalogenase H-‐1( EC:3.8.1.3 )638722485 7.53 7.74 1.05 down 7.74E-‐01 RRSL_01440 o c Hypothetical Protein638722486 7.12 8.02 1.69 down 8.38E-‐02 RRSL_01441 o c Hypothetical Protein638722487 8.03 8.7 1.45 down 1.15E-‐01 RRSL_01442 o c Hypothetical Protein638722488 9.09 9.88 1.56 down 1.01E-‐01 RRSL_01443 o c Hydroxymethylglutaryl-‐CoA lyase( EC:4.1.3.4 )638722489 8.78 9.7 1.71 down 1.06E-‐02 RRSL_01444 o c Putative 2-‐hydroxyacid dehydrogenase638722490 11.28 11.87 1.36 down 4.28E-‐02 RRSL_01445 Hypothetical Protein638722491 12.55 12.63 1.04 up 8.63E-‐01 RRSL_01446 o Hypothetical Protein638722492 10.67 10.68 1.1 up 6.33E-‐01 RRSL_01447 o c Methylcrotonyl-‐CoA carboxylase biotin-‐containing subunit( EC:6.4.1.4 )638722493 7.59 7.44 1.23 up 1.04E-‐01 RRSL_01448 o c Sensor protein kdpD( EC:2.7.3.-‐ )638722494 11.94 11.4 1.61 up 2.99E-‐02 RRSL_01449 ABC transporter substrate-‐binding protein638722495 16.63 16.86 1.06 down 5.82E-‐02 RRSL_00979 o c LSU ribosomal protein L13P638722496 16.01 16.47 1.24 down 1.77E-‐02 RRSL_00980 o c SSU ribosomal protein S9P638722497 11.22 11.5 1.1 down 1.86E-‐01 RRSL_00981 o c Hypothetical Protein638722498 12.99 13.17 1.03 down 7.87E-‐01 RRSL_00982 o c Hypothetical cytosolic protein638722499 13.22 13.48 1.08 down 4.99E-‐01 RRSL_00983 o c HesB protein family638722500 11.47 11.83 1.16 down 2.61E-‐01 RRSL_00984 o c Hypothetical protein638722501 11.71 12.13 1.22 down 8.58E-‐03 RRSL_00985 o c Tyrosyl-‐tRNA synthetase tyrS( EC:6.1.1.1 )638722502 10.66 11.73 1.9 down 1.19E-‐03 RRSL_00987 Hypothetical cytosolic protein638722503 8 8.73 1.51 down 1.41E-‐02 RRSL_00988 o c Phosphoglycerate mutase638722504 10.32 11.32 1.81 down 2.59E-‐03 RRSL_00990 o c ruvB RuvB638722505 9.9 10.92 1.83 down 6.29E-‐03 RRSL_00991 o c ruvA RuvA638722506 11.13 10.55 1.65 up 1.54E-‐01 RRSL_00992 o c Glycerophosphoryl diester phosphodiesterase( EC:3.1.4.46 )638722507 10.28 10.49 1.05 down 7.76E-‐01 RRSL_00993 o c Crossover junction endodeoxyribonuclease ruvC( EC:3.1.22.4 )638722509 10.91 11.46 1.33 down 4.03E-‐02 RRSL_00995 o c fis Fis638722510 11.47 12.4 1.73 down 1.49E-‐02 RRSL_00996 o c tRNA-‐dihydrouridine synthase638722512 13.35 12.41 2.11 up 1.04E-‐01 RRSL_00998 Hypothetical protein638722513 10.37 10.83 1.25 down 7.25E-‐02 RRSL_00999 o D-‐amino acid dehydrogenase small subunit( EC:1.4.99.1 )638722514 8.56 9.55 1.8 down 5.16E-‐02 RRSL_01000 o c 2-‐polyprenyl-‐6-‐methoxyphenol hydroxylase( EC:1.14.13.-‐ )638722515 10 10.74 1.52 down 3.61E-‐03 RRSL_01001 o c Xaa-‐Pro aminopeptidase( EC:3.4.11.9 )638722516 8.84 8.96 1.02 up 9.28E-‐01 RRSL_01002 o c Hypothetical Protein638722517 9.78 10.24 1.25 down 8.29E-‐02 RRSL_01003 o Mannose-‐1-‐phosphate guanyltransferase( EC:2.7.7.13 )638722518 9.74 10.22 1.27 down 3.50E-‐02 RRSL_01004 o c azlD AzlD638722519 11.05 11.86 1.58 down 1.68E-‐02 RRSL_01005 o c Organic solvent tolerance protein638722522 10.42 11.05 1.41 down 4.39E-‐02 RRSL_01009 o c Dimethyladenosine transferase( EC:2.1.1.-‐ )638722523 8.22 9.03 1.58 down 2.20E-‐02 RRSL_01010 o c Transporter, drug/metabolite exporter family638722524 12.2 13.17 1.77 down 1.26E-‐03 RRSL_01011 o c Lactoylglutathione lyase( EC:4.4.1.5 )638722525 14.51 15.39 1.67 down 1.24E-‐02 RRSL_00865 o c Protein Translation Elongation Factor G (EF-‐G)638722526 16.24 16.56 1.13 down 7.00E-‐02 RRSL_00866 o SSU ribosomal protein S7P638722527 15.55 16.09 1.32 down 2.49E-‐02 RRSL_00867 o c SSU ribosomal protein S12P638722529 8.57 9.34 1.54 down 2.86E-‐02 RRSL_00869 o c Methyltransferase( EC:2.1.1.-‐ )638722530 8.48 9.32 1.62 down 1.54E-‐02 RRSL_00870 o c Hypothetical Protein638722531 12.51 12.7 1.03 down 8.87E-‐01 RRSL_00871 o c Hypothetical Protein638722532 8.48 8.78 1.12 down 5.60E-‐01 RRSL_00872 o c Hypothetical exported protein638722533 7.67 8.49 1.6 down 3.22E-‐02 RRSL_00873 o c signal peptide638722534 10.86 10.76 1.18 up 6.72E-‐01 RRSL_00874 o c Conserved Hypothetical Protein638722537 13.39 14.27 1.67 down 9.36E-‐02 RRSL_00877 o c DNA-‐directed RNA polymerase beta chain( EC:2.7.7.6 )638722538 15.51 16.02 1.29 down 7.80E-‐02 RRSL_00878 o c LSU ribosomal protein L12P (L7/L12)638722539 16.5 16.86 1.16 down 1.03E-‐01 RRSL_00879 o c LSU ribosomal protein L10P638722540 14.27 15.18 1.71 down 2.44E-‐02 RRSL_00880 Hypothetical Protein638722541 14.51 15.28 1.55 down 7.35E-‐02 RRSL_00881 o c LSU ribosomal protein L1P638722542 13.62 14.81 2.07 down 6.30E-‐02 RRSL_00882 o c LSU ribosomal protein L11P638722543 14.63 14.8 1.02 down 9.29E-‐01 RRSL_00883 o c nusG NusG638722544 14.74 15.21 1.26 down 1.92E-‐01 RRSL_00884 o c Protein translocase subunit secE638722546 16.72 16.97 1.08 down 1.18E-‐01 RRSL_00885 o Protein Translation Elongation Factor Tu (EF-‐TU)638722547 15.94 16.32 1.18 down 1.80E-‐01 RRSL_RNA011 ( tRNA )638722548 16.61 16.74 1.01 up 9.36E-‐01 RRSL_RNA010 ( tRNA )638722550 10.08 10.85 1.55 down 1.07E-‐01 RRSL_00657 o DNA integration/recombination/invertion protein638722551 11.43 12.46 1.85 down 1.45E-‐01 RRSL_RNA009 ( tRNA )638722553 12.2 13.01 1.59 down 1.08E-‐01 RRSL_00659 o c Formyltetrahydrofolate deformylase( EC:3.5.1.10 )638722554 9.33 10.43 1.95 down 2.40E-‐02 RRSL_00660 o c Thiamin pyrophosphokinase( EC:2.7.6.2 )638722555 13.01 13.47 1.24 down 2.20E-‐01 RRSL_00661 o c Hypothetical Protein638722556 12.41 12.65 1.07 down 8.37E-‐01 RRSL_00662 o c Hypothetical Protein638722557 12.36 12.65 1.11 down 7.19E-‐01 RRSL_00663 o c lipid A-‐myristate beta-‐hydroxylase( EC:1.14.11.-‐ )638722559 10.19 10.26 1.05 up 5.34E-‐01 RRSL_00665 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638722560 9.06 9.5 1.24 down 7.96E-‐02 RRSL_00666 o c syrB SyrB638722561 8 8.17 1.02 down 8.73E-‐01 RRSL_00667 o c Thioredoxin reductase( EC:1.6.4.5 )638722563 8.68 8.09 1.66 up 6.15E-‐02 RRSL_00669 o c dppC DppC

638722564 7.35 7.82 1.26 down 9.31E-‐02 RRSL_00670 o dppD DppD638722565 8.55 8.21 1.4 up 1.73E-‐01 RRSL_00671 o dppF DppF638722566 10.5 10.5 1.1 up 6.81E-‐01 RRSL_00672 o c Dipeptide-‐binding protein638722567 8.83 8.85 1.09 up 5.68E-‐01 RRSL_00673 o c Hypothetical Protein638722568 7.93 7.97 1.07 up 7.29E-‐01 RRSL_00674 o c Hypothetical Protein638722569 7.62 7.89 1.09 down 4.29E-‐01 RRSL_00675 o c Oxidoreductase transmembrane probable isoquinolone 1-‐oxidoreductase (Beta-‐subunit) (E.C.1.3.99.16) (iorB2)638722570 8.43 8.57 1 down 9.93E-‐01 RRSL_00676 o c Membrane-‐bound aldehyde dehydrogenase iron-‐sulfur protein( EC:1.2.99.3 )638722571 8.23 8.56 1.14 down 1.30E-‐01 RRSL_00677 o c Hypothetical Protein638722572 14.01 14.64 1.4 down 1.58E-‐01 RRSL_00678 o c Transcriptional regulatory protein638722573 10.92 10.24 1.77 up 5.93E-‐03 RRSL_00679 o Hypothetical Protein638722575 8.17 8.05 1.2 up 2.34E-‐01 RRSL_00570 o Alkanesulfonates-‐binding protein (ssuA2)638722577 12.13 12.15 1.09 up 6.54E-‐01 RRSL_00572 o c Integral membrane protein638722578 8.76 8.9 1 up 9.87E-‐01 RRSL_00573 o Putative lipoprotein638722581 8.86 8.7 1.23 up 7.98E-‐02 RRSL_00577 o c romA RomA638722583 9.18 8.36 1.95 up 6.75E-‐02 RRSL_00579 o c Probable flagellar protein (fleN)638722584 8.59 8.13 1.52 up 2.52E-‐02 RRSL_00580 o c Probable flagellar biosynthesis protein (flhF)638722586 8.26 7.7 1.62 up 1.09E-‐01 RRSL_00582 o c Probable transmembrane flagellar biosynthetic protein (flhB)638722588 9.02 7.87 2.45 up 6.32E-‐02 RRSL_00584 o c Transporter638722590 7.73 8.19 1.24 down 1.78E-‐01 RRSL_00586 o c Shikimate 5-‐dehydrogenase( EC:1.1.1.25 )638722591 9.58 8.99 1.66 up 6.45E-‐02 RRSL_00587 o c Outer membrane porin protein 32 precursor638722592 8.19 8 1.26 up 2.18E-‐01 RRSL_00588 o c 3-‐dehydroshikimate dehydratase / 4-‐hydroxyphenylpyruvate dioxygenase( EC:1.13.11.27,EC:4.2.1.-‐ )638722594 9.66 9.77 1.02 up 9.16E-‐01 RRSL_00590 Hypothetical Protein638722595 9.63 10.12 1.28 down 4.68E-‐02 RRSL_00591 Hypothetical protein638722596 8.54 9.4 1.64 down 2.72E-‐02 RRSL_00592 VgrG protein638722597 10.67 11.49 1.6 down 6.05E-‐02 RRSL_00593 Hypothetical Protein638722598 11.86 11.38 1.54 up 1.73E-‐01 RRSL_00442 Hypothetical protein638722599 10.94 10.26 1.78 up 3.53E-‐02 RRSL_00443 Homoserine O-‐acetyltransferase( EC:2.3.1.31 )638722601 9.29 10.38 1.93 down 2.97E-‐02 RRSL_00445 o Hypothetical Protein638722602 11.48 11.45 1.13 up 5.70E-‐01 RRSL_00446 Hypothetical Protein638722603 11.83 11.98 1 down 9.86E-‐01 RRSL_00447 Probable methyltransferase( EC:2.1.1.-‐ )638722604 8.85 10.02 2.04 down 6.50E-‐02 RRSL_00448 Hypothetical protein638722605 9.09 9.44 1.15 down 3.02E-‐01 RRSL_00449 o Stringent starvation protein A638722606 9.83 9.93 1.03 up 9.12E-‐01 RRSL_00450 Branched-‐chain amino acid aminotransferase( EC:2.6.1.42 )638722608 8.92 10.06 2 down 4.92E-‐03 RRSL_00453 o Hypothetical Protein638722609 8.13 8.96 1.61 down 1.23E-‐02 RRSL_00454 o Chemotaxis motB protein638722610 10.51 11.03 1.3 down 2.00E-‐01 RRSL_00455 o Hypothetical Protein638722611 9.91 10.58 1.44 down 2.11E-‐01 RRSL_00456 o Hypothetical Protein638722612 12.53 12.48 1.14 up 2.42E-‐01 RRSL_00457 o Hypothetical Protein638722613 12.06 12.72 1.43 down 2.15E-‐01 RRSL_00458 o Hypothetical protein638722614 13.32 13.87 1.33 down 1.15E-‐01 RRSL_00459 o 3'-‐hydroxymethylcephem-‐O-‐carbamoyltransferase( EC:2.1.3.-‐ )638722615 11.39 11.98 1.37 down 6.92E-‐02 RRSL_00460 o Hypothetical Protein638722616 10.75 11.41 1.44 down 2.18E-‐01 RRSL_00462 o c carbamoyl transferase638722617 11.25 11.78 1.31 down 3.64E-‐01 RRSL_00463 o Hypothetical Protein638722618 10.92 10.86 1.15 up 1.34E-‐01 RRSL_00464 Hypothetical Protein638722619 10.69 10.93 1.07 down 7.03E-‐01 RRSL_00465 o Oxidoreductase( EC:1.1.1.-‐ )638722621 9.9 10.02 1.01 up 9.33E-‐01 RRSL_00468 o c Two-‐component sensor histidine kinase( EC:2.7.3.-‐ )638722622 10.25 10.3 1.06 up 7.21E-‐01 RRSL_00469 o c Transporter, drug/metabolite exporter family638722623 8.55 8.86 1.12 down 4.07E-‐01 RRSL_00470 o c Integral membrane protein638722624 7.7 8.29 1.37 down 6.47E-‐02 RRSL_00471 o c Putative lactonase638722626 7.74 8.08 1.15 down 3.89E-‐01 RRSL_00473 o NADH oxidase( EC:1.-‐ )638722627 8.61 9.39 1.56 down 2.78E-‐02 RRSL_00474 o Mercuric resistance operon regulatory protein638722628 9.62 9.44 1.24 up 1.45E-‐01 RRSL_00475 o c pme Pme( EC:3.1.1.11 )638722629 11.96 11.73 1.3 up 1.22E-‐01 RRSL_00476 o General secretion pathway protein D638722630 7.37 7.32 1.14 up 5.67E-‐01 RRSL_00477 o Hypothetical Protein638722631 8.99 7.52 3.05 up 8.63E-‐02 RRSL_00478 o Hypothetical Protein638722632 7.29 7.8 1.29 down 1.57E-‐01 RRSL_00479 o Hypothetical Protein638722633 6.94 7.05 1.02 up 8.79E-‐01 RRSL_00480 o Hypothetical Protein638722634 7.58 7.6 1.09 up 7.95E-‐01 RRSL_00481 o General secretion pathway protein E638722635 8.02 7.7 1.37 up 1.36E-‐01 RRSL_00482 o General secretion pathway protein F638722636 9.36 8.62 1.84 up 1.64E-‐01 RRSL_00483 o General secretion pathway protein G638722637 7.84 7.85 1.09 up 7.44E-‐01 RRSL_00484 Wall-‐associated protein precursor638722639 8.78 8.99 1.05 down 8.71E-‐01 RRSL_00842 o c Potassium-‐transporting ATPase C chain( EC:3.6.3.12 )638722640 8.5 8.3 1.26 up 5.02E-‐01 RRSL_00843 o c Potassium-‐transporting ATPase B chain( EC:3.6.3.12 )638722641 10.16 8.95 2.56 up 1.78E-‐01 RRSL_00844 o c Potassium-‐transporting ATPase A chain( EC:3.6.3.12 )638722642 10.11 9.28 1.96 up 2.57E-‐01 RRSL_00846 o c Hypothetical Protein638722643 10.68 9.21 3.06 up 9.19E-‐02 RRSL_00847 o c Hypothetical Protein638722644 8.69 9.41 1.5 down 3.50E-‐01 RRSL_00848 o c Hypothetical Protein638722645 10.43 10.7 1.1 down 7.90E-‐01 RRSL_00850 o c ABC transporter permease protein638722646 10 10.25 1.08 down 4.00E-‐01 RRSL_00851 o c Hypothetical Protein638722647 10.96 10.64 1.38 up 4.88E-‐02 RRSL_00852 o c Hypothetical Protein638722648 10.33 11.22 1.69 down 2.49E-‐02 RRSL_00853 o c Hypothetical Protein638722649 8.58 9.11 1.31 down 2.58E-‐01 RRSL_00854 o c probable COG1804, CaiB, predicted acyl-‐CoA transferases/carnitine dehydratase638722650 12.62 12.84 1.06 down 7.96E-‐01 RRSL_00855 o c Cell division inhibitor MinE638722651 12.16 12.82 1.43 down 1.13E-‐01 RRSL_00856 o c Cell division inhibitor MinD638722652 11.76 12.63 1.65 down 1.47E-‐02 RRSL_00857 o c Cell division inhibitor MinC638722653 8.75 8.02 1.84 up 1.45E-‐01 RRSL_00858 o 2',3'-‐cyclic-‐nucleotide 2'-‐phosphodiesterase / 3'-‐nucleotidase( EC:3.1.3.6,EC:3.1.4.16 )

638722654 8.33 8.28 1.15 up 4.40E-‐01 RRSL_00859 o Hypothetical Protein638722655 8.4 8.01 1.44 up 4.08E-‐02 RRSL_00860 o c 2-‐dehydropantoate 2-‐reductase( EC:1.1.1.169 )638722656 9.42 9.67 1.08 down 7.10E-‐01 RRSL_00861 o c Hypothetical Protein638722658 9.87 10.39 1.31 down 1.82E-‐01 RRSL_00527 o Hypothetical Protein638722659 8.26 8.56 1.11 down 5.54E-‐01 RRSL_00528 hypothetical protein638722660 11.81 11.66 1.23 up 2.04E-‐01 RRSL_00529 o c Transcriptional regulator, AraC family638722661 11.78 11.49 1.35 up 1.11E-‐01 RRSL_00530 Hypothetical protein638722664 7.85 7.89 1.07 up 6.96E-‐01 RRSL_00533 o c Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex( EC:2.3.1.12 )638722668 8.83 8.17 1.74 up 1.08E-‐01 RRSL_00538 Poly(3-‐hydroxyalkanoate) depolymerase( EC:3.1.1.-‐ )638722669 8.73 8.32 1.46 up 2.46E-‐01 RRSL_00539 o c 3',5'-‐cyclic-‐nucleotide phosphodiesterase( EC:3.1.4.17 )638722670 8.11 8.24 1.01 up 9.57E-‐01 RRSL_00540 o c Transporter638722671 10.29 8.32 4.32 up 5.99E-‐02 RRSL_00541 o c ABC transporter permease protein638722673 9.47 8.83 1.71 up 1.09E-‐01 RRSL_00543 o c ABC transporter substrate-‐binding protein638722674 7.27 7.35 1.04 up 8.60E-‐01 RRSL_00544 o c Transcriptional regulator, LacI family638722675 9.22 9.65 1.22 down 3.94E-‐02 RRSL_00545 o c Hypothetical protein638722676 11.16 10.33 1.96 up 1.17E-‐02 RRSL_00546 Hypothetical protein638722677 10.47 10.51 1.08 up 7.24E-‐01 RRSL_00547 o c Ankyrin homolog precursor638722678 11.26 12.32 1.89 down 1.79E-‐02 RRSL_00548 o c Hypothetical Protein638722680 10.17 10.4 1.06 down 5.08E-‐01 RRSL_00742 o c Spherulin 4 precursor638722681 8.38 8.36 1.12 up 3.75E-‐01 RRSL_00743 o c ATP/GTP binding protein638722684 9.96 11.1 2 down 8.81E-‐02 RRSL_00746 o c Hypothetical membrane spanning protein638722685 9.74 10.6 1.64 down 4.82E-‐03 RRSL_00747 Hypothetical Protein638722686 10.22 10.22 1.1 up 7.73E-‐01 RRSL_00748 Transcriptional regulator638722687 9.02 7.92 2.35 up 1.72E-‐01 RRSL_00749 czcA CzcA638722688 7.71 8.25 1.32 down 3.13E-‐01 RRSL_00750 czcB CzcB638722689 8.09 7.66 1.48 up 6.32E-‐02 RRSL_00751 o c oprM OprM638722691 8.38 8.06 1.39 up 1.03E-‐01 RRSL_00753 o Probable chemotaxis phosphataze (cheZ2)638722693 13.56 13.93 1.17 down 4.45E-‐01 RRSL_00755 o c H-‐NS-‐like proteins638722694 8.88 8.76 1.19 up 2.65E-‐01 RRSL_00757 Hypothetical protein638722699 9.36 8.9 1.52 up 4.64E-‐02 RRSL_00635 Hypothetical protein638722700 8.31 9.01 1.47 down 2.45E-‐01 RRSL_00637 Hypothetical protein638722701 10.56 10.65 1.04 up 8.95E-‐01 RRSL_00640 Core protein638722702 8.74 9.39 1.42 down 2.08E-‐01 RRSL_00641 Hypothetical Protein638722703 13.45 12.97 1.54 up 1.71E-‐02 RRSL_00642 Hypothetical Protein638722704 9.82 10.44 1.4 down 1.85E-‐01 RRSL_00643 Hypothetical Protein638722705 7.51 7.9 1.19 down 4.45E-‐01 RRSL_00644 o Hypothetical protein638722706 10.35 10.19 1.23 up 3.30E-‐01 RRSL_0644_1 o Hypothetical Protein638722707 7.95 8.88 1.72 down 3.62E-‐02 RRSL_00645 o Hypothetical Protein638722708 8.02 8.79 1.55 down 1.43E-‐01 RRSL_00647 Hypothetical protein638722712 7.88 7.54 1.39 up 8.95E-‐02 RRSL_00652 o c Probable protein-‐glutamate methylesterase (cheB)( EC:3.1.1.61 )638722713 7.72 7.61 1.19 up 2.21E-‐01 RRSL_00653 o c Probable chemotaxis diamidase (cheD)638722714 8.56 7.96 1.67 up 5.86E-‐02 RRSL_00654 o c Probable chemotaxis protein methyltransferase (cheR)638722715 13.16 13.64 1.26 down 2.66E-‐03 RRSL_00789 o c Zinc finger protein638722716 8.57 9.23 1.43 down 3.00E-‐03 RRSL_00790 Two component system histidine kinase( EC:2.7.3.-‐ )638722717 8.9 9.32 1.21 down 6.84E-‐02 RRSL_00791 Hypothetical Protein638722718 11.02 11.62 1.37 down 5.40E-‐02 RRSL_00792 o c Pterin-‐4-‐alpha-‐carbinolamine dehydratase( EC:4.2.1.96 )638722719 10.75 11.07 1.13 down 2.31E-‐01 RRSL_00794 o c Phenylalanine-‐4-‐hydroxylase( EC:1.14.16.1 )638722720 9.86 9.52 1.4 up 5.36E-‐01 RRSL_00793 Hypothetical protein638722721 8.86 9.17 1.12 down 5.19E-‐01 RRSL_00795 o c Ornithine cyclodeaminase( EC:4.3.1.12 )638722722 11.91 12.38 1.25 down 6.63E-‐02 RRSL_00796 o c signal peptide outer membrane protein W638722723 11.03 12.1 1.89 down 5.94E-‐04 RRSL_00797 o c Heavy Metal Binding Protein638722724 7.99 8.4 1.2 down 2.77E-‐01 RRSL_00798 o c Copper-‐exporting ATPase( EC:3.6.3.4 )638722725 11.25 11.33 1.04 up 7.88E-‐01 RRSL_00799 o c Lysophospholipase L2( EC:3.1.1.5 )638722726 8.84 9.49 1.41 down 1.13E-‐01 RRSL_00800 o c Oxidoreductase, GMC family( EC:1.1.99.1 )638722732 8.42 8.93 1.3 down 2.44E-‐01 RRSL_00807 o c Hypothetical Protein638722733 12.81 13.25 1.24 down 5.74E-‐03 RRSL_00808 Hypothetical Protein638722734 10.69 10.68 1.11 up 5.25E-‐01 RRSL_00809 Hypothetical Protein638722735 12.74 13.24 1.28 down 5.37E-‐02 RRSL_00594 hypothetical protein638722736 10.24 9.65 1.66 up 1.89E-‐01 RRSL_00595 hypothetical protein638722739 9.96 8.92 2.26 up 1.44E-‐01 RRSL_00599 o c Outer membrane protein638722740 7.74 7.91 1.02 down 9.34E-‐01 RRSL_00598 hypothetical protein638722742 14.93 15 1.05 up 6.95E-‐01 RRSL_00601 o c Signal peptide protein638722743 10.45 11.34 1.67 down 6.33E-‐03 RRSL_00602 hypothetical protein638722744 9.59 10.07 1.26 down 6.09E-‐02 RRSL_00603 4-‐carboxymuconolactone decarboxylase( EC:4.1.1.44 )638722745 10.38 10.24 1.22 up 4.95E-‐02 RRSL_00604 o c transmembrane protein638722746 10.44 10.1 1.4 up 1.93E-‐01 RRSL_00605 o c hypothetical protein638722747 9.14 9.53 1.19 down 1.20E-‐01 RRSL_00606 o c hypothetical protein638722748 8.57 9.09 1.3 down 9.50E-‐02 RRSL_00607 o c ragA RagA638722749 9.41 10.01 1.37 down 1.30E-‐02 RRSL_00608 o hypothetical protein638722750 8.58 8.55 1.13 up 3.67E-‐01 RRSL_00609 o hypothetical protein638722751 11.88 11.09 1.91 up 1.73E-‐01 RRSL_00610 Glycosyl transferases group 1638722753 9.39 9.13 1.31 up 2.79E-‐01 RRSL_00419 Hypothetical protein638722754 12.41 11.94 1.53 up 8.87E-‐03 RRSL_00420 Integrase/Recombinase638722755 8.96 9.26 1.12 down 3.56E-‐01 RRSL_00421 Hypothetical Protein638722756 6.99 7.59 1.37 down 5.47E-‐02 RRSL_00422 Hypothetical Protein638722758 8.99 8.84 1.22 up 3.88E-‐01 RRSL_00424 Hypothetical Protein

638722759 10.48 11.07 1.36 down 5.42E-‐02 RRSL_00425 Possible Flavoredoxin FLR638722762 10.6 11.4 1.58 down 5.81E-‐02 RRSL_00428 o c Hypothetical Protein638722763 10.74 10.91 1.02 down 9.06E-‐01 RRSL_00429 Hypothetical protein638722764 9.61 9.3 1.36 up 9.86E-‐02 RRSL_00430 o c Hypothetical Protein638722765 9.05 9.45 1.2 down 7.17E-‐02 RRSL_00431 o c Hypothetical Protein638722766 8.55 9.29 1.51 down 3.46E-‐02 RRSL_00432 o c Dethiobiotin synthetase( EC:6.3.3.3 )638722767 9.05 9.99 1.75 down 6.63E-‐03 RRSL_00433 o c 8-‐amino-‐7-‐oxononanoate synthase( EC:2.3.1.47 )638722768 8.97 10.01 1.87 down 8.40E-‐04 RRSL_00434 o c Adenosylmethionine-‐8-‐amino-‐7-‐oxononanoate aminotransferase( EC:2.6.1.62 )638722769 7.43 7.11 1.37 up 7.21E-‐02 RRSL_00435 Hypothetical Protein( EC:1.3.1.55 )638722770 6.95 7.21 1.09 down 6.83E-‐01 RRSL_00437 Benzoate 1,2-‐dioxygenase electron transfer component / Toluate 1,2-‐dioxygenase electron transfer component( EC:1.14.12.-‐,EC:1.14.12.10 )638722771 10.67 8.86 3.85 up 7.93E-‐02 RRSL_00438 Probable benzoate 1,2-‐dioxygenase beta subunit( EC:1.14.12.10 )638722773 8.01 7.28 1.84 up 1.24E-‐01 RRSL_00440 Catechol 1,2-‐dioxygenase( EC:1.13.11.1 )638722774 11.8 12.68 1.68 down 6.89E-‐02 RRSL_00441 Hypothetical Protein638722775 11.27 11.92 1.43 down 2.44E-‐01 RRSL_00367 o Glycine cleavage system transcriptional activator638722776 16.54 16.72 1.03 down 5.39E-‐01 RRSL_00368 Hypothetical Protein638722777 7.33 7.29 1.14 up 5.63E-‐01 RRSL_00369 o transposase638722780 11.17 10.41 1.87 up 4.19E-‐02 RRSL_00372 o c Cytochrome d ubiquinol oxidase subunit II( EC:1.10.3.-‐ )638722781 7.91 8.08 1.02 down 9.01E-‐01 RRSL_00373 o c 2-‐dehydropantoate 2-‐reductase( EC:1.1.1.169 )638722782 7.46 7.94 1.27 down 2.64E-‐01 RRSL_00374 o c Hypothetical Protein638722783 9.5 8.16 2.78 up 1.09E-‐01 RRSL_00375 o Translation initiation inhibitor638722784 9.55 9.37 1.25 up 3.57E-‐01 RRSL_00376 o Right origin-‐binding protein638722785 7.57 7.8 1.07 down 6.04E-‐01 RRSL_00377 o Hypothetical exported protein638722786 10.66 10.19 1.53 up 1.12E-‐01 RRSL_00378 o c Fosfomycin resistance protein638722787 8.42 9.29 1.65 down 5.13E-‐02 RRSL_00379 o c Hypothetical Protein638722788 9.63 9.92 1.11 down 3.30E-‐01 RRSL_00380 o c Hypothetical Protein638722789 7.76 8.19 1.22 down 4.13E-‐01 RRSL_00381 o c Hypothetical Protein638722790 8.75 9.05 1.12 down 6.81E-‐01 RRSL_00382 HIPA protein638722791 7.75 8.13 1.18 down 4.70E-‐01 RRSL_00383 o c Sensory transduction protein kinase( EC:2.7.3.-‐ )638722792 10.55 9.69 2 up 9.81E-‐02 RRSL_00384 o c Multidrug resistance protein B638722793 11.02 10.37 1.72 up 1.54E-‐01 RRSL_00386 o c Transcriptional regulators, LysR family638722794 8.03 7.79 1.3 up 2.20E-‐02 RRSL_00387 o c FMN-‐dependent NADH-‐azoreductase( EC:1.6.99.2,EC:3.1.4.14 )638722795 12.78 12.69 1.18 up 3.05E-‐01 RRSL_00389 o Hypothetical Protein638722796 14.07 13.38 1.78 up 1.09E-‐01 RRSL_00390 Hypothetical Protein638722797 10.35 9.16 2.53 up 9.47E-‐02 RRSL_00391 o c Hypothetical Protein638722798 9.07 9.03 1.13 up 4.72E-‐01 RRSL_00393 Hypothetical protein638722800 11.28 11.75 1.26 down 1.66E-‐02 RRSL_00395 o Hypothetical Protein638722801 7.07 7.58 1.29 down 1.68E-‐01 RRSL_00396 Polyprenyl-‐phosphate beta-‐D-‐glucosyltransferase( EC:2.4.1.78 )638722802 9.73 8.21 3.16 up 6.36E-‐02 RRSL_00397 Hypothetical protein638722803 9.32 8.68 1.71 up 2.31E-‐01 RRSL_00398 o hypothetical transmembrane protein638722804 8.39 8.65 1.09 down 6.49E-‐01 RRSL_00399 o c Transmembrane Protein; tadG1638722805 8.04 7.84 1.27 up 4.08E-‐01 RRSL_00400 o c TRANSMEMBRANE TIGHT ADHERENCE TADC-‐RELATED PROTEIN; tadC1638722806 9.02 7.84 2.51 up 1.24E-‐01 RRSL_00401 o c TRANSMEMBRANE TIGHT ADHERENCE TADB-‐RELATED PROTEIN; tadB1638722807 7.63 7.29 1.4 up 3.37E-‐01 RRSL_00402 o c SECRETION ATPASE; cpaF1638722808 8.02 7.65 1.43 up 1.98E-‐01 RRSL_00403 o c PILUS ASSEMBLY PROTEIN; cpaE1638722809 8.19 8.33 1 up 9.96E-‐01 RRSL_00404 o c lipoprotein638722810 9.08 7.47 3.38 up 9.95E-‐02 RRSL_00406 o c GspD-‐related protein; cpaC1638722811 8.48 7.94 1.6 up 5.70E-‐02 RRSL_00407 o c TRANSMEMBRANE PILUS ASSEMBLY PROTEIN; cpaB1638722812 9.99 8.86 2.42 up 1.67E-‐01 RRSL_00409 o c Prepilin Peptidase; cpaA1638722813 9.75 8.16 3.33 up 1.57E-‐01 RRSL_00410 o c Putative Pilin Protein638722817 11.32 10.65 1.75 up 1.16E-‐01 RRSL_00416 Hypothetical Protein638722818 7.19 7.14 1.14 up 4.45E-‐01 RRSL_00415 o Dihydrodipicolinate synthetase/N-‐acetylneuraminate lyase (partial ORF)638722819 8.15 7.57 1.65 up 6.56E-‐02 RRSL_00489 siderophore biosynthesis protein638722820 7.07 7.71 1.41 down 3.21E-‐02 RRSL_00490 2,3-‐dihydroxybenzoate-‐AMP ligase( EC:2.7.7.58 )638722821 9.93 9.47 1.52 up 1.04E-‐01 RRSL_00491 o c Regulatory protein638722822 10.37 8.65 3.63 up 1.13E-‐01 RRSL_00493 o c Probable transmembrane methyl-‐accepting chemotaxis protein638722823 8.41 7.7 1.8 up 6.90E-‐02 RRSL_00494 o c Hypothetical Protein638722824 7.37 6.89 1.55 up 9.06E-‐03 RRSL_00495 o c Hypothetical Protein638722825 10.81 11.61 1.59 down 5.72E-‐03 RRSL_00342 o c Replicative DNA helicase( EC:3.6.1.-‐ )638722826 13.52 14.53 1.82 down 2.65E-‐02 RRSL_00343 o c LSU ribosomal protein L9P638722827 14.63 15.65 1.84 down 1.35E-‐03 RRSL_00344 o c SSU ribosomal protein S18P638722828 16.5 16.93 1.22 down 4.16E-‐02 RRSL_00345 o c Primosomal replication protein N638722829 14.37 15.22 1.64 down 2.09E-‐02 RRSL_00346 o c SSU ribosomal protein S6P638722831 11.2 11.31 1.02 up 8.25E-‐01 RRSL_00349 o c LexA repressor( EC:3.4.21.88 )638722832 10.62 10.83 1.05 down 7.24E-‐01 RRSL_00350 Hypothetical Protein638722833 8.22 8.47 1.08 down 6.75E-‐01 RRSL_00351 Probable mannose-‐6-‐phosphate isomerase638722834 9.34 9.64 1.11 down 3.82E-‐01 RRSL_00352 o c Xaa-‐His dipeptidase( EC:3.4.13.3 )638722835 9.85 9.55 1.36 up 9.93E-‐02 RRSL_00353 o c Hypothetical Protein638722836 14 13.68 1.37 up 2.31E-‐01 RRSL_RNA008 ( tRNA )638722837 10.55 10.73 1.03 down 7.56E-‐01 RRSL_00354 o c NIFR3-‐like protein638722838 11.34 11.22 1.2 up 3.73E-‐02 RRSL_00356 o 3-‐hydroxyisobutyryl-‐CoA hydrolase( EC:3.1.2.4 )638722839 11.22 9.49 3.65 up 5.21E-‐02 RRSL_00355 C-‐5 sterol desaturase( EC:1.3.-‐ )638722840 11.96 12.88 1.72 down 3.33E-‐02 RRSL_00357 o c GTP-‐binding protein TypA/BipA638722841 11.74 10.06 3.54 up 9.45E-‐02 RRSL_00358 o c Transcriptional regulator, MarR family638722842 8.06 7.8 1.31 up 9.66E-‐02 RRSL_00359 o c Hypothetical Protein638722843 8.96 7.95 2.22 up 1.05E-‐01 RRSL_00360 Hypothetical Protein638722844 9.01 8.75 1.32 up 3.53E-‐01 RRSL_00361 o c Probable multidrug resistance protein A (emrA) MLYD family

638722845 8.37 7.62 1.85 up 1.38E-‐01 RRSL_00362 o c Multidrug resistance protein B (emrB) MFS family638722846 9.23 10.08 1.63 down 5.96E-‐02 RRSL_00363 o tRNA pseudouridine synthase B( EC:4.2.1.70 )638722847 11.89 12.19 1.11 down 3.46E-‐01 RRSL_00364 o Ribosome-‐binding factor A638722848 12.71 12.37 1.4 up 8.76E-‐02 RRSL_00551 Hypothetical Protein638722850 9.14 9.25 1.02 up 7.98E-‐01 RRSL_00553 o c Puromycin-‐sensitive aminopeptidase( EC:3.4.11.-‐ )638722851 6.91 7.08 1.02 down 7.98E-‐01 RRSL_00554 o c Nitrogen regulatory protein P-‐II638722852 8.68 8.8 1.01 up 9.53E-‐01 RRSL_00555 o c Probable transmembrane cation efflux system638722853 7.8 7.83 1.09 up 6.55E-‐01 RRSL_00556 o c cation efflux protein638722854 6.69 6.97 1.1 down 2.44E-‐01 RRSL_00557 o c Probable outer membrane cation efflux system638722860 11.35 11.61 1.09 down 4.60E-‐01 RRSL_00564 o c Molecular chaperones (DnaJ family)638722861 7.85 8.77 1.72 down 1.19E-‐02 RRSL_00566 o c hscC HscC638722862 9.41 9.18 1.29 up 5.61E-‐02 RRSL_00565 o c mntH MntH638722863 11.28 12.23 1.75 down 1.15E-‐01 RRSL_00567 o c Hypothetical Protein638722864 13.65 14.02 1.18 down 7.96E-‐01 RRSL_00612 Cold shock protein638722865 13.78 14.16 1.18 down 2.68E-‐01 RRSL_00613 o c parA ParA638722866 10.92 11.72 1.58 down 1.01E-‐01 RRSL_00614 o c parB ParB638722870 9.22 8.6 1.69 up 1.09E-‐01 RRSL_00618 o c Transporter638722871 10.72 10.17 1.61 up 8.47E-‐02 RRSL_00619 o c dctD DctD638722872 8.4 8.19 1.28 up 1.69E-‐01 RRSL_00620 o c Hypothetical membrane spanning protein638722873 12.69 12.03 1.74 up 3.12E-‐02 RRSL_00621 o c Hypothetical Protein638722874 8.42 7.81 1.68 up 3.29E-‐02 RRSL_00623 o c Sensor protein( EC:2.7.3.-‐ )638722875 9.59 9.11 1.53 up 9.24E-‐02 RRSL_00625 o c Leucine-‐, isoleucine-‐, valine-‐, threonine-‐, and alanine-‐binding protein638722876 9.8 8.12 3.53 up 7.09E-‐02 RRSL_00626 o c livH LivH638722877 10.09 8.52 3.28 up 1.08E-‐01 RRSL_00627 o c livM LivM638722878 8.28 7.62 1.74 up 1.65E-‐01 RRSL_00628 o c livG LivG638722879 8.66 8.27 1.45 up 6.70E-‐02 RRSL_00629 o c livF LivF638722880 7.9 8.3 1.2 down 2.16E-‐01 RRSL_00630 o c Transcriptional regulators, LysR family638722881 9.12 8.56 1.62 up 7.25E-‐02 RRSL_00631 o c Hypothetical protein638722882 8.79 8.71 1.17 up 4.49E-‐01 RRSL_00632 o c Chloride channel protein638722894 7.3 7.38 1.04 up 7.29E-‐01 RRSL_00283 Possible histone Acetyltransferase GNAT fam.638722895 8.46 7.97 1.55 up 3.93E-‐02 RRSL_00285 D-‐3-‐phosphoglycerate dehydrogenase( EC:1.1.1.95 )638722897 8.21 8.63 1.21 down 7.31E-‐02 RRSL_00288 Hypothetical protein638722898 8.71 8.38 1.39 up 1.05E-‐01 RRSL_00289 D-‐nopaline dehydrogenase( EC:1.5.1.19 )638722900 11.67 11.93 1.09 down 6.60E-‐01 RRSL_00307 o c dnaA DnaA638722901 13.46 13.88 1.21 down 1.11E-‐01 RRSL_00308 o c DNA polymerase III, beta chain638722902 11.92 12.38 1.25 down 2.38E-‐01 RRSL_00309 Hypothetical Protein638722903 13.28 13.19 1.17 up 8.32E-‐02 RRSL_00310 o c DNA gyrase subunit B( EC:5.99.1.3 )638722905 7.3 8.12 1.6 down 4.11E-‐02 RRSL_00312 Hypothetical Protein638722906 7.74 8.22 1.26 down 2.12E-‐01 RRSL_00313 Hypothetical protein638722908 11.96 12.86 1.69 down 1.21E-‐01 RRSL_00315 Tryptophan synthase alpha chain( EC:4.2.1.20 )638722909 10.86 11.74 1.67 down 2.92E-‐02 RRSL_00317 Hypothetical protein638722910 10.02 10.14 1.02 up 9.22E-‐01 RRSL_00319 Possible phosphohydrolases638722911 8.18 8.08 1.18 up 3.02E-‐01 RRSL_00320 Acriflavin resistance plasma membrane protein638722912 7.96 8.13 1.02 down 8.99E-‐01 RRSL_00321 Hypothetical Protein638722913 8.45 8.9 1.24 down 1.52E-‐01 RRSL_00322 Possible outer membrane protein638722914 11.09 10.64 1.5 up 6.26E-‐02 RRSL_00324 Hypothetical protein638722915 10.56 10.79 1.06 down 6.51E-‐01 RRSL_00323 o phage related protein/predicted endonuclease638722918 13.05 13.23 1.03 down 9.14E-‐01 RRSL_RNA005 ( tRNA )638722921 10.77 10.08 1.77 up 6.48E-‐02 RRSL_00292 o c Na+ driven multidrug efflux pump (MATE family)638722922 10.08 10.41 1.14 down 2.87E-‐01 RRSL_00293 o c Hypothetical Protein638722923 14.58 15.57 1.81 down 1.04E-‐02 RRSL_00294 o c LSU ribosomal protein L31P638722924 9.82 10.23 1.21 down 1.16E-‐01 RRSL_00295 o c Hypothetical Protein638722925 11.31 11.3 1.11 up 5.96E-‐01 RRSL_00296 o c Transcriptional regulator638722926 7.78 7.23 1.61 up 5.09E-‐03 RRSL_00298 o c Transcriptional regulatory protein638722927 13.72 14.03 1.12 down 4.43E-‐01 RRSL_00299 o c rho Rho638722928 13.22 13.84 1.39 down 1.09E-‐01 RRSL_00300 o c Thioredoxin638722929 9.08 8.89 1.26 up 3.36E-‐02 RRSL_00301 o c Hypothetical cytosolic protein638722930 8.83 9.06 1.06 down 5.01E-‐01 RRSL_00302 o c ATP-‐dependent nuclease subunit A638722932 12.28 13.3 1.83 down 3.80E-‐02 RRSL_00304 o c Hypothetical transcriptional regulatory protein638722934 10.28 11.2 1.71 down 1.11E-‐01 RRSL_00306 o c recR RecR638722935 8.01 7.41 1.67 up 6.01E-‐02 RRSL_00326 hypothetical protein638722936 8.38 8.12 1.33 up 1.96E-‐01 RRSL_00327 o c ATP-‐dependent DNA helicase pcrA( EC:3.6.1.-‐ )638722937 9.34 9.34 1.1 up 7.01E-‐01 RRSL_00328 o c Transporter638722938 9.17 8.83 1.39 up 2.36E-‐01 RRSL_00329 o c Hypothetical membrane spanning protein638722939 8.37 8.67 1.12 down 4.73E-‐01 RRSL_00331 o c Hypothetical Protein638722940 10.55 10.1 1.51 up 1.16E-‐01 RRSL_00332 Hypothetical Protein638722941 7.8 8.6 1.58 down 2.78E-‐02 RRSL_00333 o probable signal peptide638722942 9.28 9.66 1.18 down 4.41E-‐01 RRSL_00334 o Hypothetical Protein638722944 7.98 8.24 1.09 down 5.30E-‐01 RRSL_00337 o c Transcriptional regulators, LysR family638722945 10.3 10.32 1.09 up 5.36E-‐01 RRSL_00338 o c Hypothetical Protein638722946 9.46 8.79 1.75 up 1.32E-‐02 RRSL_00339 o Acetyl-‐coenzyme A synthetase( EC:6.2.1.1 )638722947 8.79 9.06 1.09 down 5.36E-‐01 RRSL_00340 o c Hypothetical membrane spanning protein638722950 8.62 8.31 1.37 up 1.89E-‐01 RRSL_00221 Short chain dehydrogenase( EC:1.-‐ )638722951 7.77 7.81 1.07 up 7.14E-‐01 RRSL_00222 Hypothetical protein638722952 8.5 8.97 1.26 down 1.88E-‐01 RRSL_00223 o c 23S rRNA methyltransferase( EC:2.1.1.-‐ )638722953 9.45 10.4 1.76 down 4.19E-‐02 RRSL_00224 o c Ribonuclease HII( EC:3.1.26.4 )

638722954 10.01 11.01 1.82 down 7.42E-‐02 RRSL_00225 o c Lipid-‐A-‐disaccharide synthase( EC:2.4.1.182 )638722956 11.87 12.76 1.68 down 3.87E-‐02 RRSL_00227 o c (3R)-‐hydroxymyristoyl-‐[acyl carrier protein] dehydratase( EC:4.2.1.-‐ )638722957 12.18 13.05 1.65 down 1.28E-‐02 RRSL_00228 o c UDP-‐3-‐O-‐[3-‐hydroxymyristoyl] glucosamine N-‐acyltransferase( EC:2.3.1.-‐ )638722958 12.08 12.95 1.66 down 1.35E-‐01 RRSL_00229 o c Hypothetical Protein638722959 11.7 12.29 1.36 down 3.08E-‐01 RRSL_00230 o c Outer membrane protein638722960 13.39 13.27 1.2 up 8.45E-‐02 RRSL_00231 o c Membrane metalloprotease638722961 10.13 10.96 1.61 down 1.42E-‐01 RRSL_00232 o c 1-‐deoxy-‐D-‐xylulose 5-‐phosphate reductoisomerase( EC:1.1.1.267 )638722962 12.65 12.92 1.1 down 6.57E-‐01 RRSL_00233 o c Phosphatidate cytidylyltransferase( EC:2.7.7.41 )638722963 10.99 12.13 1.99 down 5.35E-‐02 RRSL_00234 o c Undecaprenyl pyrophosphate synthetase( EC:2.5.1.31 )638722964 14.24 14.56 1.13 down 4.48E-‐01 RRSL_00235 o c Ribosome Recycling Factor (RRF)638722965 11.8 12.87 1.91 down 2.48E-‐02 RRSL_00236 o c Uridylate kinase( EC:2.7.4.-‐ )638722967 8.77 8.91 1 up 9.79E-‐01 RRSL_00238 Hypothetical protein638722970 8.2 8.22 1.09 up 7.99E-‐01 RRSL_00245 Hypothetical Protein638722973 11.26 11.05 1.28 up 1.33E-‐01 RRSL_00258 o c corB CorB638722974 11.15 11.76 1.38 down 2.36E-‐01 RRSL_00259 o c PilB, Type IV pilus protein638722975 12.31 12.65 1.15 down 3.52E-‐01 RRSL_00260 o c PilC638722976 10.38 10.71 1.14 down 3.83E-‐01 RRSL_00261 o c PilD, Type 4 prepilin peptidase( EC:3.4.99.-‐ )638722977 10.28 10.58 1.11 down 3.23E-‐01 RRSL_00262 o c Dephospho-‐CoA kinase( EC:2.7.1.24 )638722978 11.36 12.31 1.75 down 7.71E-‐02 RRSL_00263 o c Hypothetical protein638722979 12.58 13.09 1.29 down 5.77E-‐02 RRSL_00264 o c Hypothetical Protein638722980 11.03 11.91 1.68 down 2.19E-‐02 RRSL_00265 o c MutT638722984 8.31 9.08 1.54 down 1.76E-‐01 RRSL_00269 o c Cell wall endopeptidase, family M23/M37638722985 11.83 12.28 1.24 down 5.29E-‐01 RRSL_00270 o c Hypothetical Protein638722986 11.94 12.69 1.53 down 6.11E-‐03 RRSL_00177 o c ABC transporter ATP-‐binding protein638722987 9.23 9.92 1.45 down 8.87E-‐03 RRSL_00178 o c Muramoyltetrapeptide carboxypeptidase( EC:3.4.17.13 )638722988 11.32 12.28 1.78 down 1.17E-‐02 RRSL_00179 o c queD QueD638722989 11.84 12.56 1.49 down 4.71E-‐03 RRSL_00181 o c Queuosine biosynthesis protein QueE638722990 9.82 8.3 3.18 up 7.02E-‐02 RRSL_00180 Hypothetical Protein638722992 8.84 9.15 1.12 down 5.59E-‐01 RRSL_00183 o c HIPA protein638722993 8.81 8.02 1.91 up 1.98E-‐02 RRSL_00184 o c Arabinose efflux permease (AraJ)638722994 8.54 8.89 1.16 down 2.94E-‐01 RRSL_00185 Transcriptional regulators, LysR family638722995 8 8.69 1.46 down 8.52E-‐02 RRSL_00186 Possible beta-‐lactamase type II638722996 9.3 9.86 1.34 down 8.61E-‐02 RRSL_00187 o Thioredoxin638722997 8.24 8.78 1.31 down 1.98E-‐01 RRSL_00188 o 2'-‐5' RNA ligase638722998 8.56 9.09 1.31 down 2.68E-‐01 RRSL_00189 o Protocatechuate 3,4-‐dioxygenase alpha chain( EC:1.13.11.3 )638722999 10.27 10.44 1.02 down 9.56E-‐01 RRSL_00190 o c Protocatechuate 3,4-‐dioxygenase beta chain( EC:1.13.11.3 )638723000 9.02 9.44 1.21 down 2.19E-‐01 RRSL_00191 o Hypothetical Protein638723001 14.65 14.67 1.09 up 5.59E-‐01 RRSL_00192 o Transposase638723002 10.23 9.02 2.55 up 6.90E-‐02 RRSL_00166 Hypothetical Protein638723003 7.65 7.85 1.04 down 8.44E-‐01 RRSL_00167 Hypothetical Protein638723004 8.68 8.42 1.32 up 1.44E-‐01 RRSL_00168 o Hypothetical Protein638723006 11.91 12.12 1.05 down 6.86E-‐01 RRSL_00170 o Hypothetical Protein638723009 8.34 9.11 1.55 down 1.45E-‐01 RRSL_00248 o Methyltransferase( EC:2.1.1.-‐ )638723010 8.65 7.94 1.81 up 1.12E-‐01 RRSL_00249 o Sensor protein uhpB( EC:2.7.3.-‐ )638723011 8.59 8.3 1.35 up 1.90E-‐01 RRSL_00250 o Transcriptional regulatory protein638723012 8.46 7.8 1.74 up 1.16E-‐01 RRSL_00251 o Hemagglutinin-‐related protein638723013 8.45 8.23 1.28 up 4.14E-‐01 RRSL_00252 o Tetratricopeptide repeat family protein638723014 7.42 7.56 1 up 9.91E-‐01 RRSL_00253 o Tetratricopeptide repeat family protein638723015 6.91 6.98 1.05 up 7.65E-‐01 RRSL_00254 o Hypothetical Protein638723016 7.84 7.53 1.37 up 1.91E-‐01 RRSL_00255 o Adenylylsulfate kinase( EC:2.7.1.25 )638723018 10.23 11.36 1.98 down 1.43E-‐02 RRSL_00205 o c Hypothetical Protein( EC:2.5.1.19 )638723019 10.17 11.18 1.83 down 3.56E-‐02 RRSL_00206 o c Cytidylate kinase( EC:2.7.4.14 )638723020 15.85 16.23 1.18 down 1.18E-‐02 RRSL_00207 o c SSU ribosomal protein S1P638723022 13.62 13.89 1.09 down 4.49E-‐01 RRSL_00209 o c Hypothetical Protein638723023 10.95 11.63 1.45 down 1.36E-‐01 RRSL_00210 o c Tetratricopeptide repeat family protein638723024 9.46 10.75 2.21 down 5.92E-‐02 RRSL_00211 o c UDP-‐glucose 6-‐dehydrogenase( EC:1.1.1.22 )638723025 12.57 13.53 1.77 down 1.02E-‐01 RRSL_00212 o c D-‐glycero-‐D-‐manno-‐heptose-‐7-‐phosphate 1-‐kinase( EC:2.7.1.-‐ )638723026 12.25 13.14 1.68 down 5.00E-‐02 RRSL_00213 o c ADP-‐L-‐glycero-‐D-‐manno-‐heptose-‐6-‐epimerase( EC:5.1.3.20 )638723028 11.57 12.08 1.28 down 5.27E-‐02 RRSL_00215 o c Cysteine synthase( EC:2.5.1.47,EC:4.2.99.8 )638723029 10.23 11.14 1.7 down 5.89E-‐02 RRSL_00217 o c Membrane-‐bound lytic murein transglycosylase B( EC:3.2.1.-‐ )638723031 8.9 7.51 2.9 up 8.32E-‐02 RRSL_00193 o Hypothetical Protein638723032 7.99 8.24 1.08 down 7.52E-‐01 RRSL_00194 o Acetylornithine aminotransferase( EC:2.6.1.11 )638723033 8.83 9.01 1.02 down 9.22E-‐01 RRSL_00195 3-‐oxoacyl-‐[acyl-‐carrier protein] reductase( EC:1.1.1.100 )638723034 8.92 9.22 1.11 down 3.31E-‐01 RRSL_00196 Possible transcriptional regulator of sugar metabolism638723035 7.73 7.74 1.1 up 6.08E-‐01 RRSL_00197 Hypothetical protein638723037 8.64 8.01 1.71 up 5.05E-‐02 RRSL_00199 Probable pyrodoxal phosphate biosynthesis protein638723038 7.38 7.41 1.08 up 6.40E-‐01 RRSL_00200 Probable iron containing alcohol dehydrogenase II638723040 10.54 9.03 3.14 up 7.03E-‐02 RRSL_00202 Hypothetical Protein638723043 13.16 13.2 1.07 up 3.24E-‐01 RRSL_00158 Core protein638723044 12.73 13.33 1.37 down 1.49E-‐01 RRSL_00160 VgrG protein638723045 7.91 8.03 1.02 up 9.49E-‐01 RRSL_00163 o Transposase638723046 15.92 15.98 1.06 up 5.84E-‐01 RRSL_00165 Hypothetical Protein638723054 11.81 11.92 1.02 up 8.49E-‐01 RRSL_00142 o c oppB OppB638723055 11.55 11.45 1.18 up 2.54E-‐01 RRSL_00143 o c oppC OppC638723056 9.58 10.48 1.69 down 6.11E-‐02 RRSL_00144 o c oppF OppF638723057 14.07 14.47 1.2 down 1.13E-‐01 RRSL_00145 o c Hypothetical Protein

638723058 9.77 10.62 1.64 down 2.88E-‐02 RRSL_00146 o c Serine protease( EC:3.4.21.-‐ )638723060 14.75 15.26 1.29 down 7.08E-‐03 RRSL_00133 o c UDP-‐glucuronate 4-‐dehydrogenase (decarboxylating)( EC:1.1.1.-‐ )638723061 11.36 12.45 1.94 down 2.12E-‐02 RRSL_00134 o c Chitooligosaccharide deacetylase( EC:3.5.1.-‐ )638723062 11.43 12.1 1.45 down 8.14E-‐02 RRSL_00135 o c oxidoreductase, bacterioferritin co-‐migratory protein638723063 12.77 12.03 1.85 up 3.87E-‐02 RRSL_00136 o c probable conserved hypothetical protein638723064 8.34 8.63 1.12 down 7.49E-‐01 RRSL_00137 o c Hypothetical Protein638723065 9.28 10.16 1.66 down 5.55E-‐02 RRSL_00138 o c invasion-‐associated protein, p60638723068 12.23 11.73 1.55 up 2.06E-‐01 RRSL_00121 o 1,4-‐alpha-‐glucan branching enzyme( EC:2.4.1.18 )638723069 8.74 9.69 1.75 down 5.70E-‐03 RRSL_00122 o Trehalose synthase638723070 15.26 15.45 1.03 down 8.55E-‐01 RRSL_00092 Hypothetical Protein638723071 10.86 11.16 1.12 down 5.44E-‐01 RRSL_00093 Hypothetical protein638723072 12.19 12.45 1.08 down 5.09E-‐01 RRSL_00094 o VgrG protein638723073 10.03 10.93 1.69 down 1.77E-‐01 RRSL_00095 o Hypothetical Protein638723074 10.31 11.15 1.63 down 1.46E-‐01 RRSL_00096 o Hypothetical protein638723076 9.07 9.62 1.32 down 2.57E-‐01 RRSL_00113 o c Mercuric reductase( EC:1.16.1.1 )638723078 9.45 8.47 2.16 up 6.06E-‐02 RRSL_00115 Hypothetical Protein638723079 7.49 7.91 1.21 down 1.38E-‐01 RRSL_00119 o c Hypothetical Protein638723080 14.96 15.33 1.17 down 4.40E-‐01 RRSL_00120 Hypothetical Protein638723081 8.71 7.73 2.19 up 6.52E-‐02 RRSL_00125 o c Hypothetical Protein638723082 7.82 7.51 1.37 up 2.17E-‐01 RRSL_00126 o c Vitamin B12 receptor638723083 9.42 9.36 1.15 up 3.30E-‐01 RRSL_00127 o c ATP synthase epsilon chain( EC:3.6.3.14 )638723084 7.05 7.34 1.11 down 4.79E-‐01 RRSL_00128 Probable oxidoreductase638723085 10.12 8.76 2.84 up 8.15E-‐02 RRSL_00130 Possible periplasmic iron-‐binding protein638723086 7.87 7.54 1.39 up 2.11E-‐01 RRSL_00131 Possible phosphonoacetaldehyde hydrolase( EC:3.11.1.1 )638723087 11.4 11.01 1.45 up 4.68E-‐02 RRSL_00105 o c Hypothetical protein638723090 9.13 7.79 2.78 up 6.89E-‐02 RRSL_00108 Transcriptional regulators, LysR family638723091 7.5 7.58 1.04 up 7.05E-‐01 RRSL_00109 o c phnT PhnT( EC:3.6.3.25 )638723092 7.19 7.33 1 down 9.97E-‐01 RRSL_00110 Hypothetical protein638723093 11.21 11.61 1.2 down 2.57E-‐01 RRSL_00071 o c Hypothetical Protein638723094 10.22 10.3 1.04 up 7.43E-‐01 RRSL_00072 o c Hypothetical membrane spanning protein638723095 8.83 8.71 1.2 up 2.32E-‐01 RRSL_00073 o c Undecaprenyl-‐phosphate-‐4-‐amino-‐L-‐arabinose-‐-‐ lipid A 4-‐amino-‐L-‐arabinosyltransferase( EC:2.4.2.-‐ )638723096 13.41 13.82 1.2 down 4.69E-‐01 RRSL_00074 o c transmembrane small multi-‐drug resistance protein638723097 11.04 12.03 1.8 down 1.55E-‐03 RRSL_00075 o c UDP-‐4-‐amino-‐L-‐arabinose synthase( EC:2.6.1.-‐ )638723099 10.11 11.13 1.83 down 1.18E-‐02 RRSL_00077 Undecaprenyl-‐phosphate alpha-‐4-‐amino-‐L-‐arabinosyltransferase( EC:2.7.8.-‐ )638723101 9.78 10.83 1.88 down 7.37E-‐03 RRSL_00067 o Peptide synthetase638723102 9.24 9.85 1.38 down 1.07E-‐01 RRSL_00068 o Hypothetical Protein638723103 9.61 9.81 1.04 down 8.37E-‐01 RRSL_00069 o Hypothetical Protein638723104 11.38 11.99 1.39 down 2.63E-‐01 RRSL_00097 o c Phosphoenolpyruvate synthase( EC:2.7.9.2 )638723105 10.15 10.82 1.44 down 1.57E-‐02 RRSL_00098 o c Hypothetical Protein638723106 12.49 12.58 1.03 up 5.55E-‐01 RRSL_00099 o c stomatin like protein638723107 11.52 12 1.27 down 8.24E-‐02 RRSL_00100 o c SsrA-‐binding protein638723108 11.33 11.56 1.06 down 7.02E-‐01 RRSL_00101 o c Hypothetical cytosolic protein638723109 8.96 9.44 1.27 down 1.96E-‐01 RRSL_00102 o c Hypothetical Protein638723113 10.02 10.77 1.52 down 7.42E-‐02 RRSL_00085 o c lpxK LpxK( EC:2.7.1.130 )638723114 13.59 13.78 1.03 down 6.77E-‐01 RRSL_00086 o c conserved cytosolic protein638723115 9.36 10.15 1.56 down 5.26E-‐02 RRSL_00087 o c 3-‐deoxy-‐manno-‐octulosonate cytidylyltransferase( EC:2.7.7.38 )638723116 11.86 12.28 1.22 down 1.83E-‐01 RRSL_00088 o c Adenylate kinase / Nucleoside-‐diphosphate kinase( EC:2.7.4.3,EC:2.7.4.6 )638723118 9.65 8.83 1.94 up 4.92E-‐02 RRSL_00061 o Glycine cleavage system transcriptional activator638723120 9.9 9.5 1.46 up 1.29E-‐01 RRSL_00062 o c Gamma-‐glutamyltranspeptidase( EC:2.3.2.2 )638723123 12.05 11.21 1.97 up 1.04E-‐02 RRSL_00065 Hypothetical Protein638723124 7.75 7.08 1.75 up 1.77E-‐01 RRSL_00059 hypothetical membrane protein638723125 7.59 7.49 1.19 up 4.40E-‐01 RRSL_00060 Peptide synthetase638723126 7.76 8.79 1.85 down 2.68E-‐02 RRSL_00056 o c Hypothetical Protein638723127 10.8 11.77 1.77 down 7.93E-‐02 RRSL_00051 o c Hypothetical Protein638723128 6.79 6.81 1.09 up 5.95E-‐01 RRSL_00052 o c Hypothetical Protein638723129 8.17 8.24 1.05 up 6.48E-‐01 RRSL_00043 Shikimate kinase( EC:2.7.1.71 )638723130 9.93 10.64 1.49 down 2.42E-‐01 RRSL_00080 o Hypothetical Protein638723132 9.84 9.44 1.45 up 1.19E-‐01 RRSL_00017 Hypothetical protein638723133 12.63 13.48 1.63 down 3.99E-‐02 RRSL_00048 o c GMP synthase (glutamine-‐hydrolyzing)( EC:6.3.5.2 )638723134 13.39 14.06 1.44 down 6.94E-‐02 RRSL_00050 o c Inosine-‐5'-‐monophosphate dehydrogenase( EC:1.1.1.205 )638723135 8.09 7.67 1.48 up 1.18E-‐01 RRSL_00047 Hypothetical Protein638723137 10.64 10.93 1.11 down 7.36E-‐01 RRSL_00040 o PhoP/Q-‐regulated protein PqaA638723138 8.1 7.84 1.32 up 2.39E-‐01 RRSL_00041 Hypothetical Protein638723139 9.25 9.36 1.02 up 9.22E-‐01 RRSL_00035 o c Malate:quinone oxidoreductase( EC:1.1.99.16 )638723140 9.93 10.72 1.57 down 4.79E-‐02 RRSL_00026 probable enoyl-‐[acyl-‐carrier-‐protein] reductase (NADH)( EC:1.3.1.9 )638723141 9.33 10.17 1.62 down 8.77E-‐02 RRSL_00027 Probable acetate kinase638723142 10.36 11.23 1.66 down 9.71E-‐02 RRSL_00028 Probable phosphate acetytransferase( EC:2.3.1.19,EC:2.3.1.8 )638723143 8.94 10.23 2.22 down 8.53E-‐02 RRSL_00029 Hypothetical protein638723145 8.91 8.65 1.31 up 1.77E-‐01 RRSL_00037 o c Hypothetical membrane spanning protein638723146 7.65 8.08 1.23 down 2.75E-‐01 RRSL_00038 o c Transcriptional regulators, LysR family638723147 11.56 12.35 1.57 down 6.86E-‐03 RRSL_00018 o Methyltransferase( EC:2.1.1.-‐ )638723148 8.26 9.01 1.52 down 6.74E-‐02 RRSL_00019 NAD(FAD)-‐utilizing dehydrogenases638723149 7.73 8.27 1.32 down 1.97E-‐01 RRSL_00044 o c D-‐amino acid dehydrogenase small subunit( EC:1.4.99.1 )638723150 10.39 10.54 1.01 down 9.29E-‐01 RRSL_00045 o c Glutamate/aspartate-‐binding protein638723151 9.65 9.85 1.04 down 8.76E-‐01 RRSL_00011 o Hemolysin activator protein precursor638723152 10.93 10.31 1.69 up 5.67E-‐03 RRSL_00008 o integral membrane acetyltransferase

638723154 6.31 6.89 1.35 down 9.33E-‐02 RRSL_00004 NAD(P)H dehydrogenase (quinone)( EC:1.6.99.2 )638723155 6.11 6.5 1.19 down 2.97E-‐02 RRSL_00005 Phosphatidylglycerophosphatase A( EC:3.1.3.27 )638723157 8.83 8.17 1.74 up 1.31E-‐01 RRSL_00002 Hypothetical Protein

aMicroarray gene ID tag from custom-designed chipbGene absolute expression values were based on four biological replicates, normalized using the Robust Multichip Algorithm as described under Methods.cDirection of expression difference in planta relative to in bacteria at comparable cell densities in culture. Genes were considered differentially expressed if the difference in normalized gene expression values was greater than 2-fold at a P-value <0.05. Genes significantly up- and downregulated are labeled in orange and blue, respectively.dProbabilistic statistical analysis (Student’s t-test) was used to identify differentially expressed (DE) genes. After selection of candidate DE genes, a P-value was calculated for each gene. The false discovery rate (FDR, Benjamini Hochberg) adjustment for multiple testing correction was applied to the P- value to reduce the number of false positives and to increase the chances of identifying all the differentially

eo –Gene belongs to the set of strain UW551-GMI1000 orthologs were defined as pair-wise best BLAST hits between the UW551 and GMI1000 genomes that also have >70% amino acid identity over >70% of the protein.fc – Gene belongs to the R. solonaceraum Core Genome, as defined by Guidot et al. [14] and personal communication from B. Remenant and P. Prior

UW551 in!planta andinrichmedium SequenceIDAE@value28IPAE ...

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Transcript of UW551 in!planta andinrichmedium SequenceIDAE@value28IPAE ...

UW551 in!planta andinrichmedium SequenceIDAE@value*28*IPAE ...

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Transcript of UW551 in!planta andinrichmedium SequenceIDAE@value*28*IPAE ...

UW551 in!planta andinrichmedium SequenceIDAE@value28IPAE ...

Transcript of UW551 in!planta andinrichmedium SequenceIDAE@value28IPAE ...