Use of pesticides and residues in wine Patrizia Restani SCRAISIN - March 2009 Patrizia Restani...

Use of pesticides and residues in wine

Use of pesticides and residues in wine

Patrizia Restani

SCRAISIN - March 2009

Patrizia Restani

SCRAISIN - March 2009

Scientific Opinion of the Panel on Plant Protection Products and their Residues (PPR)

(Question N° EFSA-Q-2006-160)Adopted on 15 April 2008

Scientific Opinion of the Panel on Plant Protection Products and their Residues (PPR)

(Question N° EFSA-Q-2006-160)Adopted on 15 April 2008

The combined toxicity of two or more compounds can take three possible forms: dose-addition, response-addition, or interaction. However, having considered the evidence on the different forms of combined toxicity and their potential relevance to risk assessment for pesticide residues at the levels occurring in food, the PPR Panel limited this opinion to the possible impact of dose addition.

In particular, the PPR Panel noted that although toxic interactions from pesticide residues in food cannot be ruled out, there is no empirical evidence for their occurrence at the expected levels of exposure from pesticide residues in food.

The combined toxicity of two or more compounds can take three possible forms: dose-addition, response-addition, or interaction. However, having considered the evidence on the different forms of combined toxicity and their potential relevance to risk assessment for pesticide residues at the levels occurring in food, the PPR Panel limited this opinion to the possible impact of dose addition.

In particular, the PPR Panel noted that although toxic interactions from pesticide residues in food cannot be ruled out, there is no empirical evidence for their occurrence at the expected levels of exposure from pesticide residues in food.

MRLsMRLs

Maximum Residue Levels reflect levels of pesticides that could occur in products, which are treated in accordance with Good Agricultural Practices

Maximum Residue Levels reflect levels of pesticides that could occur in products, which are treated in accordance with Good Agricultural Practices

RfD Definition

NOAELRfD= -------------

UFwhereNOAEL is No observed adverse effect levelUF is uncertainty

Espressed as mg/kg body weight

Acute RfDAcute RfD

An estimate of a daily oral exposure for an acute duration (24 hours or less) to the human population (including susceptible subgroups) that is likely to be without an appreciable risk of adverse health effects over a lifetime

An estimate of a daily oral exposure for an acute duration (24 hours or less) to the human population (including susceptible subgroups) that is likely to be without an appreciable risk of adverse health effects over a lifetime

Acceptable Daily Intake

NOEL or NOAELADI = ------------------------

SFNO(A)EL = the highest dose without (adverse) effect in laboratory animalsEspressed as mg/kg body weight

SF = safety factor (10-1000)

MRL and European UnionMRL and European Union

http://ec.europa.eu/sanco_pesticides/public/index.cfmhttp://ec.europa.eu/sanco_pesticides/public/index.cfm

Pesticide residues CommitteeFirst quarter 2008: grape

Pesticide residues CommitteeFirst quarter 2008: grape

PRC Conclusions (211 pesticides researched):None of the residues detected would be expected to have an effect on health.Published 25 September 2008 by http://www.pesticides.gov.uk/prc_home.asp

Pesticide residues CommitteeFirst quarter 2008: wine

Pesticide residues CommitteeFirst quarter 2008: wine

Published 25 September 2008 by http://www.pesticides.gov.uk/prc_home.asp

Searched 237 pestidicesScreening risk assessments were done for all residues found. None of residuesfound gave acute intakes the ARfD or ADI . Combined risk Assessment: None required.

Dossier Pesticidi nel piattoLEGAMBIENTE 2008

Dossier Pesticidi nel piattoLEGAMBIENTE 2008

International Estimated Daily Intake

IEDI = Σ (Residues in each vegetable x average consumption)

Values expressed as mg/kg b.w.

Problems:1.Different diets in geographical area (EFSA 26 diets for chronic intake, 18 for acute intake)2.Groups of consumers (newborn, children and adults)

RISK FROM PESTICIDE PRESENT IN VEGETABLES

Percentage distribution the ratio NEDI/ADI for pesticides found in vegetables in Italy (2004-2006)

Percentage distribution of pesticides according to the safety factor in Italy (2004-2006)

Use of pesticides and residues in wine Patrizia Restani SCRAISIN - March 2009 Patrizia Restani...

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