US EPA, Pesticide Product Label, FRONTLINE PLUS FOR ......2012/04/24  · Apply en ire contents of...

11
., . UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460-0001 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION April 24, 2012 Ms. Ka-en C. Cunningham, DVM, DABVP Head, Regulatory Affairs North America Merial Jmited 3239 Satellite Boulevard, Building 500 Duluth, GA 30096-4640 Subject: Amended Master Labeling; Removal of 2-Year Time-Limited Registration Restriction FRONTLINE® Plus For Cats, EPA Reg. No. 65331-4 Your Submission Dated April 13, 7012 Dear Ks. Cunningham: The labeling referred to above, submitted in connection with registration under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), as amended, is acceptable. In direct response to Merial Limited's submission (September 9, 2011) of enhanced reporting of adverse events for its FRONTLINE® products (EPA Reg. Nos. 65331-2, 65331-3, 65331-4, and 65331-5), the following changes are being made to the terms and conditions of the subject product registration as a result of EPA's recent review (copy enclosed) of this submission: 1. The 2-year time-limited registration restriction has been removed from the subject product registration. 2. Merial's reporting of enhanced incident data is now only required on an annual basis, rather than on a quarterly basis because 7 years of enhanced incident data reporting have been provided and these data did not demonstrate a concern. Please note that this product is still subject to all other previously required conditions of registration, including the spot-on mitigation. A copy of your label stamped "Accepted" is enclosed for your records along with a hard copy of the HED review completed for the subject product. If you have any questions about this label review, please contact Mr. Carmen J. Rodia, Jr. at (703) 306-0327 or via e-mail at Rod/[email protected]. Sincerely Yours, O Richard J. Gebken Product Manager (10) Insecticide Branch Registration Division (7504P) Enclosures: Label stamped "Accepted" HED Memo: "Fipronil Spot-On Products: Conditional Registration and Enhanced Reporting," dated February 27, 2012 065331-00104 D463903

Transcript of US EPA, Pesticide Product Label, FRONTLINE PLUS FOR ......2012/04/24  · Apply en ire contents of...

Page 1: US EPA, Pesticide Product Label, FRONTLINE PLUS FOR ......2012/04/24  · Apply en ire contents of the applicator in o single spot diredly onto the cot's skin. Do not apply on top

., .UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460-0001

OFFICE OF CHEMICAL SAFETYAND POLLUTION PREVENTION

April 24, 2012

Ms. Ka-en C. Cunningham, DVM, DABVPHead, Regulatory Affairs North AmericaMerial Jmited3239 Satellite Boulevard, Building 500Duluth, GA 30096-4640

Subject: Amended Master Labeling; Removal of 2-Year Time-Limited Registration RestrictionFRONTLINE® Plus For Cats, EPA Reg. No. 65331-4Your Submission Dated April 13, 7012

Dear Ks. Cunningham:

The labeling referred to above, submitted in connection with registration under the Federal Insecticide,Fungicide and Rodenticide Act (FIFRA), as amended, is acceptable.

In direct response to Merial Limited's submission (September 9, 2011) of enhanced reporting of adverseevents for its FRONTLINE® products (EPA Reg. Nos. 65331-2, 65331-3, 65331-4, and 65331-5), the followingchanges are being made to the terms and conditions of the subject product registration as a result of EPA's recentreview (copy enclosed) of this submission:

1. The 2-year time-limited registration restriction has been removed from the subject product registration.2. Merial's reporting of enhanced incident data is now only required on an annual basis, rather than on a

quarterly basis because 7 years of enhanced incident data reporting have been provided and these datadid not demonstrate a concern.

Please note that this product is still subject to all other previously required conditions of registration,including the spot-on mitigation. A copy of your label stamped "Accepted" is enclosed for your records along with ahard copy of the HED review completed for the subject product. If you have any questions about this labelreview, please contact Mr. Carmen J. Rodia, Jr. at (703) 306-0327 or via e-mail at Rod/[email protected].

Sincerely Yours,

ORichard J. GebkenProduct Manager (10)Insecticide BranchRegistration Division (7504P)

Enclosures: Label stamped "Accepted"HED Memo: "Fipronil Spot-On Products: Conditional Registration and Enhanced Reporting," dated February 27, 2012

065331-00104 D463903

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Tech' ical area -.No p- nt except prod, barcode

Step!.OPEt* ApplicatorHold upright with foil side toward YJUand snap applicator tip.

Step 2.

APPLY FRONTLINE PlusPart the caf s hair above the shoulderblades, at the base of the neck. Placethe applicator tip just above the skinand squeeze. Apply entire contents ofthe applicator in a single spot directlyonto the cat's skin. Do not apply on tcpof the hair coat. Avoid contact withtreated area until dry.

Questions or Comments?Call: 1-800-660-1842,Monday-Friday, 8am-8pm EST orvisit us at www.FRONTLINE.com

* 3 0 0 0 0 0 0 * BACK

FOR

For us: ONLY on CATS » KITTENS 8 weeks orolder: Post-acting, long-lasting, waterprooftreotrr !M ond control of fleas, flea eggs &larvae, ricks, chewing lice and mosquitoes.ACTIVl': 1HGREDIEN1Sfi proni 1 .... ..................._........_..... 9.8%(Sj-mii'hoprene 11.8%IHERTIHGREDIEHTS 78.4%TOTAL 100.0%KttP OUT OF REACH OF CHILDREN

CAUTIONFRON'TJNE* Plus for Cats:Fleas• Kills lieas. fleo eggs ond fleo larvae• Prevents all fleo stages (eggs, larvae, pupae)

from leveloping• Stop: existing infestations ond prevents

establishment of new infestations• Kills lleas which may cause flea allergy

derrr ititisTicks• Kills nil life stages of ticks (lorvo. nymph ond

odut', including brown dog ticks(Rhip':cephalussanguineus). American dogticks Dermocentor rariaMis). lone star ticks(Amr.tyommo omenconum) and deer ticks(txoc'rts scopu/oris)

• Kills licks that may transmit Lyme diseose,haer' obortonellosis. ehrlichiosis, bobesiosis.onopljsmosis and other tick-borne diseases

Lice• Rapidly eliminates chewing lice infestationsMosquitoes• Kills mosquitoesFRON'IINE Plus is approved for use onall cars, including:• Breeding, pregnant, ond loctoting queens• Kitte' s as young as 8 weeks

ACCEPTED

One spot application is all that's needed:FRONTLINE Plus spreads from the single pointof application, rapidly covering the ertire cat andIoca'izin9 ir tne nair- on ttle surface of the skin andin the sebaceous glands. These glords act as areservoir, continuously replenishing RONTUNEPlus onto the skin ond hair coat, so it keepsworking even if the cat gets wet.Fleas, ticks, and chewing lice are killed quickly aftercoming into contact with a treated cct. Fleas andticks do not need to bite the cat in ord 3r to die.DIRECTIONS FOR USEIt Is a violation of Federal Law to use trvs product ina manner inconsistent with its labeling. Do notallow children to apply product. TC PREVENTHARM TO YOU AND YOUR fET. READENTIRE LABEL AND DIRECTIONS BEFOREEACH USE. FOLLOW ALL DIRE CT'ONS ANDPRECAUTIONARY STATEMENTS CAREFULLY.USE ON CATS ONLY. DO NO' USE ONRABBITS. DO NOT USE ON OTHEf ANIMALS.To kill fleas, flea eggs & larvae, ticks, chewing liceand mosquitoes apply FRONTLIN -. Plus forCats as follows:• OPEN ApplicatorHold upright with foil side toward ycu and snapapplicator tip.• APPLY FRONTLINE PlusPart the col's hair obove the shoulder t lodes, at thebase of the neck. Place the opplicutor tip justabove the skin and squeeze. Apply en ire contentsof the applicator in o single spot diredly onto thecot's skin. Do not apply on top of the hair coat.Avoid contact with treated area until d y.FRONTLINE Plus for Cats is oppnwed for useon all cots, including breeding, pregnant, andloctating queens ond kittens as younr. os 8 weeks.FRONTLINE Plus remains effectivi! even afterbathing, waler immersion, or exposure to sunlight.FREQUENCY OF APPLICATIONWhen used monthly, FRONTL NE Pluscompletely breaks the flea life cycle nnd controlstick and ch*wing lice infestations. Do not reapplyFRONTLINE Plus for 30 days.FRONTLINE Plus kills adult fleas, flf o eggs, andflea larvae for up to six weeks. FRONTLINE Plus

Kills fleas, flea eggs & larvae,ticks & chewing lice & mosquitoes• Fast-acting• Long-lasting• Waterproof

Kills ticks, including those that maytransmit Lyme disease

fipronil:(S>methoprene:INERT INGPCDIEHTS-

9.6%11.8%

. ....78.4%mvL ................................... 100%Contains 1 -0.01 7 (1 oz (0.50 ml) applicator1 monthly dose

FOR CATSEPA Reg. No. 65331-4

EPAEst.65331-FR-2MADE IN FRANCE

For use ONLY onCATS & KITTENS

CAUTION

See inside panelsfor FIRST AID and'PRECAUTIONARY

statements.

\ FRONT

also prevents development of all flea stages for upto six weeks. FRONTLINE Plus can control fleasfor up to six weeks, however, if there is a high risk olreinfesfation or'if the cat has fleas which maycause fleo allergy dermatitis, a once monthlyapplication may be needed.FRONTLINE Plus kills ticks for at least onemonth. A once monthly application isrecommended where tick control is needed.FRONTLINE Plus kills all life sloges of ticks(larva, nymph ond adult). FRONTLINE Plus killsticks that may transmit Lyme diseose.hoemobartonellosis, ehrlichiosis. bobesiosis.anaplosmosis and other tick-borne diseases.FRONTLINE Plus kills chewing lice for at leastone month. A once monthly application isrecommended where chewing lice control isneeded.FRONTLINE Plus kills mosquitoes within 24 hoursfor up to 14 days, ond within 48 hours for up to28 days with a monthly application.STORAGE AND DISPOSALDo not contaminate wafer, food, or feed by storageond disposal.STORAGE. Slore unused product in originalcontainer only, out of reach of children andanimals.PESTICIDE DISPOSAL. If partly filled: Callyour local solid waste agency or 1-800-CLEANUPfor disposal instructions. Never ploce unusedproduct down any indoor or outdoor drain.CONTAINER DISPOSAL. If empty:Nonrefillable container. Do not reuse or refill thiscontainer. Ploce in trash or offer for recycling ifavailable.FIRSTAIDHave the product container or label with you whencolling a poison control center or doctor, or goingfor treatment.IF SWALLOWED: Call a poison control center ordoctor immediately for treatment advice. Haveperson sip a gloss of water if able to swallow. Donot induce vomiting unless told to do so by apoison control center or doctor. Do not giveanything by mouth to an unconscious person.

Under the Federal Insecticide, Fungickfe,and f; odenticide Act, as amended, for the

pesticide registered under

EPA. Reg. Mn-

INSIDE ; PANELS

IF IN EYES: Hold eye open and rinse slowly andgently with water for 15-20 minutes. Removecontact lenses, if present, after the first 5 minutes,then continue rinsing eye. Coll a poison controlcenter or doctor for treatment advice.IF ON SKIN OR CLOTHING: Take offcontaminated clothing. Rinse skin immediatelywith plenty of water for 15-20 minutes. Call opoison control center or doctor for treatmentadvice.PRECAUTIONARY STATEMENTSHAZARDS TO HUMANS. CAUTION.Harmful if swallowed. Causes eye irritation. Avoidcontact with skin, eyes or clothing. Wash handsthoroughly with soap ond water otter handling andbefore eating, drinking, chewing gum. or usingtobacco.HAZARDS TO DOMESTIC ANIMALS.For external use only. Do not use on kittens under8 weeks of age. Individual sensitivities, while rare,may occur after using any pesticide product. Petsmay experience some temporary irritation at thesite of product application. If signs persist, orbecome more severe within a few days ofapplication, consult o veterinarian immediately.Certain medicotions can interact with pesticides.Consult a veterinarian before using on medicoted,debilitated or aged animals. Call 1 -800-660-1842.Monday-Friday. 8om-8pm EST.PHYSICAL OR CHEMICAL HAZARDSCOMBUSTIBLE: Do not use or store near heat oropen flame.WARRANTYTo the extent consistent with applicable low, sellermakes no warranty, expressed or implied,concerning the use of this pruouu other thanindicated on the label. Buyer assumes oil risk ofuse ond handling of this material when such useand handling ore contrary to lot jl :r'frictions.

Meriol Limited32o9 oote.li.j Jvd.Dui'lth. GA 300^6-4640. USA©FRONTLINE is a registered fotemnrk of Merial.©10'. 1 XriJ Limited, Duli-*h,6A.AII rights reserved.

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°

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FRONTJKills fleas, flea eggs & larvae,ticks, chewing lice & mosquitoes

Fast-actingLong-lastingWaterproof

Kills ticks, includingthose that maytransmit Lyme disease

PROTOTYPE GRAPHICS

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<oo«-l\

FRONTUNEffv/yzstfU&f&

FRONTLINE* Plus for Cols is:• Fast-acting• Long-lasting• Waterproof

One spot application is all that's needed:FRONTLINE Plus spreads from the single point of application, rapidly covering theentire cat and localizing in the hair, on the surface of the skin and in the sebaceousglands. These glands act as a reservoir, continuously replenishing FRONTLINE Plusonto the skin and hair coat, so it keeps working even if the cat gets wet.Fleas, ticks and chewing lice ore killed quickly after coming into contact with a treatedcat. Fleas and ticks do not need '0 bite the cat in order to die.

FRONTLINE Plus for Cats:Fleas• Kills fleas, flea eggs and flea lavae• Prevents all flea stages (eggs, .arvae. pupae) from developing• Stops existing infestations and prevents establishment of new infestations• Kills fleas which may cause fleii allergy dermatitisTicks• Kills all life stages of ticks (larva, nymph and adult), including deer ticks (Ixodes

scapularis), brown dog ticks (Mpicephalus sanguineus), American dog ticks(Dermocentor variabilis) and Icne star ticks (Amblyomma americonum)

• Kills ticks that may transmit Lyme disease. Rocky Mountain spotted fever, ehrlichiosis,babesiosis. anaplasmosis, haemobartonellosis and other tick-borne diseases

Lice Mosquitoes• Rapidly eliminates chewing lied infestations • Kills mosquitoes

FRONTLINE Plus is approved 'or use on all cats, including:Breeding, pregnant, and lactatng queensKittens as young as 8 weeks

Adult Fleas

Flea Eggs

Flea Larvae

Ticks

Chewing Lice

Mosquitoes

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(

How to Apply

FRO,>FORCATS

Step 1. To REMOVE Applicator:Lift and remove the plastic tab to exposefoil backing; then peel away the foil.Or use scissors to open.

Step 2. ApplicatorHold upright with foil side toward youand snap applicator tip.

Step 3. APPLY FRONTLINE PlusPart the cat's hair above the shoulderblades, at the base of the neck. Placethe applicator tip just above the skinand squeeze. Apply entire contents ofthe applicator in a single spot directlyonto the cat's skin. Do not apply on topof the hair coat. Avoid contact withtreated area until dry.

Questions or Comments?Call: 1-800-660-1842,Monday-Friday, 8am-8pm EST orvisit us at www.FRONTLINE.com

Page 7: US EPA, Pesticide Product Label, FRONTLINE PLUS FOR ......2012/04/24  · Apply en ire contents of the applicator in o single spot diredly onto the cot's skin. Do not apply on top

jap/Opue

ig* §

t 98 X

0) 01d LL!

a. Q_UI UJ

SAHfJfif ff S1VO UCM7A/J) as" JO

FRONTLINE Plus for Cats provides fasf-acting, long- asting. waterproof treatment and controlof fleas, ticks, chewing lice & mosquitoes for use ONLY on cats and kittens 6 weeks or older.

Directions for UseIt is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Donot allow children to apply product. TO PREVENT HARM TO YOU AND YOUR PET. READ ENTIRE LABEL ANDENCLOSED DIRECTIONS BEFORE EACH USE. FOLLOW ALL DIRECTIONS AND PRECAUTIONARY STATEMENTSCAREFULLY. USE ON CATS ONLY. DO NOT USE ON RABBITS. DO NOT USE ON OTHER ANIMALS.

To kill fleas, flea eggs & larvae, licks, chewing lice and nosquitoes apply FRONTLINE Plus for Cats os follows:• To REMOVE Applicator: Lift and remove the plastic tab to expose foil backing; then peel away the foil. Or use

scissors to open.• OPEN Applicator. Hold upright with foil side toward yoj and snap applicotor lip.• APPLY FRONTLINE Plus. Parl the cat's hair above th3 shoulder blades, at the base of the neck. Place

the applicotor tip just above the skin and squeeze. Apply entire contents of the applicator in a single spotdirectly onto the cat's skin. Do not apply on top of the hoir coat. Avoid contact with treated area until dry.

FRONTLINE Plus for Cats is approved for use on all :ots. including breeding, pregnant, and lactating queensand kittens as young os 8 weeks.FRONTLINE Plus remains effective even after bathing, woter immersion, or exposure to sunlight.

Frequency of ApplicationWhen used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing liceinfestations. Do not reapply FRONTLINE Plus for 30 dtiys.FRONTLINE Plus kills adult fleas, flea eggs, and flea Icrvoe for up to six weeks. FRONTLINE Plus olso preventsdevelopment of all flea stages for up to six weeks. FRONTLINE Plus can control fleas for up to six weeks, however,if there is a high risk of reinfestation or if the cat has fleus which moy cause flea allergy dermatitis, a once monthlyapplication moy be needed.FRONTLINE Plus kills ticks for at least one month. A once monthly applicotion is recommended where tickcontrol is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult). FRONTLINE Plus killsticks that may transmit Lyme disease, Rocky Mountain s jotted fever, ehrlichiosis, babesiosis, anaplosmosis,hoemobartonellosis and other tiok-borne diseases.FRONTLINE Plus kills chewing lice for at least one moith. A once monthly application is recommended wherechewing lice control is needed.FRONTLINE Pius kills mosquitoes within 24 hours for up to 14 doys. and within 48 hours for up to 28 days.with a monthly application.

AIUO esn too joj

>use EPA Est. 65331-FR-2

Lse: EFAEsit. 74528-CH&-1

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TO REMOVE APPLICATOR:• Lift and remove the plastic tab

to expose foil backing; then peelaway the foil. Or use scissors to open.

0.017 flOZLot*

CAT

TO REMOVE APPLICATOR:Lift ond remove the plastic tab

to expose foil backing; then peelaway th3 foil. Or use scissors to open.

0.017flozLot*

CAT

TO REMOVE APPLICATOR: *Lift and remove the plastic tab *

to expose foil backing; then peelaway the foil. Or use scissors to open.

0.017 flOZLot#

CAT

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0.017 fl ozFRONTUNf

masKeen MI of Men of dill*™

See full label foradditional directionsCAUTION

EPA Reg. No. 65331-4

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r

FORCATS

For use ONIK on CATS & KITTENS 8 weeks or older:Fast-acting, long-lasting, waterproof treatment and control cffleas, flea eggs & larvae, ticks, chewing lice and mosquitoes.ACTIVE INGREDIENTSfipronil: 9.8%(5>methoprene 11.8%INERT INGREDIENTS 78.4%TOTAL 100.09,

KEEP OUT OF REACH OF CHILDRENCAUTION

FRONTLINE9 Plus for Cats:Fleas• Kills fleas, flea eggs and flea larvae• Prevents all flea stages (eggs, larvae, pupae) from developing• Stops existing infestations and prevents establishment of new

infestations• Kills fleas which may cause flea allergy dermatitisTicks• Kills all life stages of ticks (larva, nymph and adult), including

brown dog ticks (Rhipicepholus sanguineus). American dog tick;(Dermacentor variabilis), lone star ticks (Arnblyommaamericanum) and deer ticks (Ixodes scapularis)

• Kills ticks that may transmit Lyme disease, haemobartonellosis,ehrlichiosis, babesiosis, anaplosmosis and other tick-borne disease >

Lice• Rapidly eliminates chewing lice infestationsMosquitoes• Kills mosquitoesFRONTLINE Plus is approved for use on all cats,including:• Breeding, pregnant, and lactating queens• Kittens as young as 8 weeksOne spot application is all thafs needed:FRONTLINE Plus spreads from the single point of applicator,rapidly covering the entire cot and localizing in the hair, on thosurface of the skin and in the sebaceous glands.These glands actas a reservoir, continuously replenishing FRONTLINE Plus onti)the skin and hair coat, so it keeps working even if the cat gets wet.Fleas, ticks, and chewing lice are killed quickly after coming intocontact with a treated cat. Fleas and ticks do not need to bite the catin order to die.DIRECTIONS FOR USEIt is a violation of Federal Law to use this product in a mannerinconsistent with its labeling. Do not allow children to apply produc.TO PREVENT HARM TO YOU AND YOUR PET. READENTIRE LABEL AND DIRECTIONS BEFORE EACH USE.FOLLOW ALL DIRECTIONS AND PRECAUTIONARYSTATEMENTS CAREFULLY. USE ON CATS ONLY. DO NOTUSE ON RABBITS. DO NOT USE ON OTHER ANIMALS.To kill fleas, flea eggs & larvae, ticks, chewing lice and mosquitoe;apply FRONTLINE Plus for Cats as follows:• To REMOVE Applicator: Lift and remove the plastic tab to exposofoil backing; then peel away the foil. Or use scissors to open.• OPEN ApplicatorHold upright with foil side toward you and snap applicator tip.• APPLY FRONTLINE PlusPart the cat's hair above the shoulder blades, at the base of thoneck. Place the applicator tip just above the skin and squeeze. Appl"entire contents of the applicator in a single spot directly onto thi;cat's skin. Do not apply on top of the hair coat. Avoid contact withtreated area until dry.

* 7 0 0 0 0 0 0 *

FRONTLINE Plus for Cats is approved for use on all cats,including breeding, pregnant, and lactating queens and kittens asyoung as 8 weeks.FRONTLINE Plus remains effective even after bathing, waterimmersion, or exposure to sunlight.FREQUENCY OF APPLICATIONWhen used monthly, FRONTLINE Plus completely breaks the flealife cycle and controls tick and chewing lice infestations. Do notreapply FRONTLINE Plus for 30 days.FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for upto six weeks. FRONTLINE Plus also prevents development of allflea stages for up to six weeks. FRONTLINE Plus can control fleasfor up to six weeks, however, if there is a high risk of reinfestation orif the cat has fleas which may cause flea allergy dermatitis, a oncemonthly application may be needed.FRONTLINE Plus kills ticks for at least one month. A oncemonthly application is recommended where tick control isneeded. FRONTLINE Plus kills all life stages of ticks (larva,nymph and adult). FRONTLINE Plus kills ticks that may transmitLyme disease, haemobartonellosis, ehrlichiosis, babesiosis,anaplasmosis and other tick-borne diseases.FRONTLINE Plus kills chewing lice for at least one month. Aonce monthly application is recommended where chewing licecontrol is needed.FRONTLINE Plus kills mosquitoes within 24 hours for up to 14days, and within 48 hours for up to 28 days with a monthlyapplication.STORAGE AND DISPOSALDo not contaminate water, food, or feed by storage and disposal.STORAGE. Store unused product in original container only, out ofreach of children and animals.PESTICIDE DISPOSAL If partly filled: Call your local solidwaste agency or 1-800-CLEANUP for disposal instructions. Neverplace unused product down any indoor or outdoor drain.CONTAINER DISPOSAL. If empty: Nonrefillable container.Do not reuse or refill this container. Place in trash or offer forrecycling if available.FIRSTAIDHave the product container or label with you when calling a poisoncontrol center or doctor, or going for treatment.IF SWALLOWED: Coll a poison control center or doctorimmediately for treatment advice. Have person sip a glass of waterif able to swallow. Do not induce vomiting unless told to do so by apoison control center or doctor. Do not give anything by mouth to anunconscious person.IF IN EYES: Hold eye open and rinse slowly and gently with waterfor 15-20 minutes. Remove contact lenses, if present, after the first5 minutes, then continue rinsing eye. Call a poison control center ordoctor for treatment advice.IF ON SKIN OR CLOTHING: Take off contaminated clothing.Rinse skin immediately with plenty of water for 15-20 minutes. Calla poison control center or doctor for treatment or advice.PRECAUTIONARY STATEMENTSHAZARDS TO HUMANS. CAUTION.Harmful if swallowed. Causes eye irritation. Avoid contact with skin,eyes or clothing. Wash hands thoroughly with soap and water afterhandling and before eating, drinking, chewing gum. or using tobacco.HAZARDS TO DOMESTIC ANIMALS.For external use only. Do not use on kittens under 8 weeks of age.Individual sensitivities, while rare, may occur after using anypesticide product. Pets may experience some temporary irritation atthe site of product application. If signs persist, or become moresevere within a few days of application, consult a veterinarianimmediately. Certain medications can interact with pesticides.Consult a veterinarian before using on medicated, debilitated oraged animals. Call 1 -800-660-1842, Monday-Friday, 8am-8pm EST.PHYSICAL OR CHEMICAL HAZARDSCOMBUSTIBLE: Do not use or store near heat or open flame.WARRANTYTo the extent consistent with applicable law, seller makes nowarranty, expressed or implied, concerning the use of this productother than indicated on the label. Buyer assumes all risk of use andhandling of this material when such use and handling are contraryto label instructions.EPA Reg. No. 65331-4Meriol Limited3239 Satellite Blvd.Duluth.GA3009W640.USA©FRONTLINE is o registered trademark of Meriol.©2011 Merial Limited. Dulutti, GA.AII rights reseived.

FRIIN1 BACK

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\ \Dt\ \

RQNTUNE

To successfully control fleas and tic<s, alldogs and cats must be treated with their owndose of FRONTLINE".

v' Apply according to label instructions,ensuring the product is applied to the skin,not on top of the fur and not near the collar.It may be helpful to remove the collar beforeapplication, so it doesn't absorb the product.

•J Remember, your pet needs to be do at thetime FRONTLINE Is applied and remain jry24 hours after application.

v' Verify pipette is empty after applied ion(multiple squeezes may be necessary toapply the entire dose).

v Even indoor pels need flea and tick :ontrolbecause you or other pets in the houset oldmay bring fleas irro the home. These floascan lead to a flea nfestation.

O f*}T^p

Ticks Chewing

It can take up to3 months to get rid of

o serious flea infestation) of all of the flea life stages that

existed BEFORE you stoned using FRONTLINE.

The adult fleas on your pet may justbe the tip of the infestation iceberg.

ittuf f lfot life uf /.-• '^C rftp

The average flea life cycle in thehome is about 21 days long.

To ensure continued protection ot yourPets> use these stickers as a reminderto apply and re-purchase FRONTLINE.

After treating your pet for the first time,peel off the sticker and place on yourcalendar rhat day.

ouisnoHs?Contact yout veterinarianm call our tedmicnlexperts at1-SOO-060-I842,Monday^ ridoy, 8am-8ptn.For more information, visitwww.FRONTUNE.tom

6 Monthsuse all 6 stickers

3 Months

Place the remaining stickers on yourcalendar as a reminder to applyFRONTLINi; monthly.

©FRONTLINE is oregistered trademarkofMeriol.©2011 Main1 tinted,Duluth,GA.All lights reserved.