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urr Issues Intest Microbiol.2006 Sep;7(2):73-89.

Lactic acid bacteria as probiotics.

Ljun! "#$%&str' .

Source

*ep%rtent o+ Me&ic%l Microbiolo,# *er%tolo, %n& In+ection# Lun& niersit,# S'le%t%n 23# S/-

223 62 Lun Se&en. "s%.Ljun!1e&.lu.se

Abstract

" nuber o+ L%ctob%cillus species# i+i&ob%cteriu sp# S%cc!%ro,ces boul%r&ii# %n& soe ot!er

icrobes !%e been propose& %s %n& %re use& %s probiotic str%ins# i.e. lie icroor%niss %s +oo&

suppleent in or&er to bene+it !e%lt!. !e !e%lt! cl%is r%ne +ro r%t!er %ue %s reul%tion o+

boel %ctiit, %n& incre%sin o+ ell-bein to ore speci+ic# suc! %s eertin %nt%onistic e++ect on t!e

%stroenteric p%t!oens 4lostri&iu &i++icile# 4%p,lob%cter jejuni# 5elicob%cter p,lori %n& rot%irus#

neutr%lisin +oo& ut%ens pro&uce& in colon# s!i+tin t!e iune response to%r&s % !2 response#

%n& t!ereb, %llei%tin %lleric re%ctions# %n& loerin seru c!olesterol (%nnoc# 2002).n+ortun%tel,# ost public%tions %re c%se reports# uncontrolle& stu&ies in !u%ns# or reports o+ %ni%l

or in itro stu&ies. $!et!er or not t!e probiotic str%ins eplo,e& s!%ll be o+ !u%n oriin is % %tter o+

&eb%te but t!is is not % %tter o+ concern# %s lon %s t!e str%ins c%n be s!on to surie t!e tr%nsport

in t!e !u%n %strointestin%l (I) tr%ct %n& to colonise t!e !u%n l%re intestine. !is inclu&es

suri%l in t!e stress+ul enironent o+ t!e sto%c! - %ci&ic p5 %n& bile - it! in&uction o+ ne enes

enco&in % nuber o+ stress proteins. Since t!e %%il%bilit, o+ %ntioi&%nts &ecre%ses rostr%ll, in t!e

I tr%ct pro&uction o+ %ntioi&%nts b, colonic b%cteri% proi&es % bene+ici%l e++ect in sc%enin +ree

r%&ic%ls. L" str%ins coonl, pro&uce %ntiicrobi%l subst%nce(s) it! %ctiit, %%inst t!e

!ooloous str%in# but L" str%ins %lso o+ten pro&uce icrobici&%l subst%nces it! e++ect %%inst

%stric %n& intestin%l p%t!oens %n& ot!er icrobes# or copete +or cell sur+%ce %n& ucin bin&in

sites. !is coul& be t!e ec!%nis be!in& reports t!%t soe probiotic str%ins in!ibit or &ecre%se

tr%nsloc%tion o+ b%cteri% +ro t!e ut to t!e lier. " protectie e++ect %%inst c%ncer &eelopent c%nbe %scribe& to bin&in o+ ut%ens b, intestin%l b%cteri%# re&uction o+ t!e en,es bet%-

lucuroni&%se %n& bet%-lucosi&%se# %n& &econju%tion o+ bile %ci&s# or erel, b, en!%ncin t!e

iune s,ste o+ t!e !ost. !e l%tter !%s %ttr%cte& consi&er%ble interest# %n& L" !%e been teste&

in seer%l clinic%l tri%ls in %lleric &ise%ses. 4!%r%cteristics %scribe& to % probiotic str%in %re in ener%l

str%in speci+ic# %n& in&ii&u%l str%ins !%e to be teste& +or e%c! propert,. Suri%l o+ str%ins &urin

pro&uction# p%cin %n& stor%e o+ % i%ble cell %ss !%s to be teste& %n& &ecl%re&.

http://www.ncbi.nlm.nih.gov/pubmed/16875422http://www.ncbi.nlm.nih.gov/pubmed?term=Ljungh%20A%5BAuthor%5D&cauthor=true&cauthor_uid=16875422http://www.ncbi.nlm.nih.gov/pubmed?term=Ljungh%20A%5BAuthor%5D&cauthor=true&cauthor_uid=16875422http://www.ncbi.nlm.nih.gov/pubmed?term=Wadstr%C3%B6m%20T%5BAuthor%5D&cauthor=true&cauthor_uid=16875422http://www.ncbi.nlm.nih.gov/pubmed?term=Wadstr%C3%B6m%20T%5BAuthor%5D&cauthor=true&cauthor_uid=16875422http://www.ncbi.nlm.nih.gov/pubmed/16875422http://www.ncbi.nlm.nih.gov/pubmed?term=Ljungh%20A%5BAuthor%5D&cauthor=true&cauthor_uid=16875422http://www.ncbi.nlm.nih.gov/pubmed?term=Wadstr%C3%B6m%20T%5BAuthor%5D&cauthor=true&cauthor_uid=16875422