Unlocking the Mysteries of the Developing Brain · the creation of a unique convergence of...

Thanks to dramatic advances in personalized medicine, we are poised to revolutionize care for children with brain disorders.

Unlocking the Mysteries of the Developing Brain

It Starts With YES

A breathtaking truth: We are only a moment away from remarkable breakthroughs in brain science — earlier diagnoses, new treatments, revolutionary cures.

A heartbreaking one: Our breakthroughs are not close enough for some children. That realization spurs us on — in research, clinical trials and philanthropy. We can — and must — do more.

Fast-growing and constantly changing, a child’s brain is both ruggedly resilient and breathtakingly fragile — and develops perfectly much of the time.

However, when a four-year-old develops a brain tumor; when a toddler endures six seizures a day; when a second-grader can’t sit still for five minutes; when a two-year-old isn’t speaking yet; when a high-schooler withdraws from her friends and family — the effects on both child and family can be swift, devastating and enduring.

The Campaign for Seattle Children’s 1

With your philanthropic support, we have a once-in-a-lifetime opportunity to lead this revolution.

Our journey with our daughter Carmen began Labor Day weekend 2003 when we noticed she wasn’t acting like the happy, attentive 3-year-old we knew so well. It took a week to confirm the diagnosis that Carmen had a tumor in her brain causing a type of epilepsy that was complicated and difficult to control with medication. By the time she was diagnosed, Carmen was having up to eight seizures a day.

Five months after her first epileptic seizure, Carmen underwent a 10-hour brain surgery at Seattle Children’s. Today, 15 years later, what stands out most is how everyone who cared for Carmen treated her as if she was their own child.

— Steve and Carolyn Conforti

We’re on the brink of a revolution in neurology, neurosurgery and brain health: entering an era in which we move beyond treating symptoms to understanding the underlying mechanisms — and customizing treatment for each individual patient.

An era in which we can prevent and even cure epilepsy and other disorders.

An era in which we teach brains to recover more quickly and fully from surgery or trauma — and surgery becomes both rare and revolutionary.

Ultimately, it’s an era where we understand how brain disorders are connected — to each other and to brain development — allowing us to help each child live the fullest life possible.

With your philanthropic support, we have a once-in-a-lifetime opportunity to lead this revolution. Already philanthropy has funded the creation of a unique convergence of visionary research and world-class clinical care at Seattle Children’s.

Now, with further support, we can make additional discoveries that will benefit our own patients and families and help millions of other kids and families around the world.

2 It Starts With YES

Personalized Medicine:Treatments Unique to Each Child.

At Seattle Children’s, we’re discovering the causes of some of the most complex neurological disorders and challenges kids face: Epilepsy. Brain tumors. Autism. ADHD. With your support, we can transform our discoveries into game-changing personalized treatments and go even further to predict and prevent brain injuries and disorders in kids.

Understanding the IndividualBrain disorders are as individualized as kids themselves. Just as DNA affects a child’s hair color, height and vision, it also affects his or her particular form of epilepsy, autism or other neurological disorder. Yet if we only needed to understand genetics in order to understand a child’s brain disorder, it would be simple.

Instead, brain disorders interact with brain development. This makes each disorder unique to a child’s genetic makeup and developmental stage — and far more complex than any adult neurological condition.

With every step we take to understand the specifics of a child’s problem, we move a step closer to breakthroughs in diagnosis and precision treatment for kids everywhere.

Revolutionizing CareTo understand brain disorders in children, we focus on how genes regulate brain development, and the role they play in causing and interacting with brain disorders. We focus on understanding both healthy brain development and what happens when a child’s brain experiences a disruption. And we focus on how a disruption that causes one brain disorder could later cause another.

A disruption in healthy development could be caused by anything: an injury, a genetic difference or an environmental trigger. And any disruption — from a stroke to a tumor to a concussion — has the potential to impact that child’s life far beyond the initial medical treatment and recovery.


A child who has a brain tumor may later have a seizure. A child with epilepsy may experience depression or be diagnosed with autism. A child with an acute brain injury such as a stroke or brain infection may — a year later — suffer from poor attention or anxiety. In order to truly revolutionize care for children with brain disor-ders, we need to understand and address the relationships between the disorders themselves and the lifelong mental health complications they may cause.

Building Powerful Connections It’s not enough to stop a child’s seizures or remove a tumor when we know that brain disorders are interrelated. That’s why we focus, like no other children’s hospital, on connections. Connections between experts across medical disciplines. Connections outside our walls to understand a family’s experiences and environ-ment. Connections between kids who need care and visionary donors who are compelled to make a difference.

No one else has our team of experts: scientists with unparalleled understanding of genetics and nervous system development; clinicians who are national and international experts for cutting-edge treatments of brain tumors, epilepsy, stroke and acute brain injuries; and multidisciplinary teams looking at the mental and behavioral health implications of brain disorders. We are at a point of medical excel-lence in neurosciences, yet know we need to do better for kids. We need you.

Together, we can translate discoveries into life-changing advances in custom-tailored treatments — treatments that allow every child to live life to their full potential.


Individualized Approaches for Kids With Epilepsy:Discovery-Driven Treatments.

Epilepsy is the most common childhood brain disorder in the United States. Early intervention and preventing seizures is crucial — seizures can create scar tissue, slow brain development and raise the risk of later disability, including changes in personality and behavior.

However, childhood epilepsy is not one disease, it’s many. Even though one child’s seizures may look just like another child’s, the underlying cause is often completely different. This is why person-alized medicine is the key to new treatments for kids with epilepsy.

Breaking the CycleAbout 25% of all kids who have epilepsy develop intractable epilepsy; their seizures do not respond to medication. Sometimes kids have the option of brain surgery and sometimes — unacceptably

— they are out of options. The remaining 75% may need multiple medications that still do not fully control their seizures. Even when their seizures can be treated, all kids who suffer from epilepsy are at risk for mental health problems and about half experience depression.

Years of medications with serious side effects —medications that can themselves impact brain development — and sometimes seizures return? And even if they don’t return, a child might later have depression or another serious mental health disorder? We must break this cycle.

Current medications are not effective because they do not treat the source of a child’s epilepsy: the specific pathway or mechanism in a child’s brain causing seizures. With you as our partner, we can do much more for kids with epilepsy. We

Lillee Haynes, 4, was having hundreds of seizures each day until she sought treatment at Seattle Children’s. She underwent two neurosurgeries to remove the diseased area of her left brain, allowing her healthy brain to grow and develop.

YES

Can we find — and fix — the source of a toddler’s seizures?


can break the cycle of ineffective medications and understand the brain mechanisms behind typical and atypical brain development. We can better integrate mental health care with clinical and surgical care to support a child’s psychosocial needs. We can bring new hope to families and children with debilitating seizures.

Leaders in Clinical CareOur epilepsy clinical care is already cutting edge. We’re the Pacific Northwest’s top-ranked epilepsy program and the only pediatric one rated Level 4 — the highest possible — by the National Association of Epilepsy Centers. We are consistently ranked among the nation’s best neurosciences programs and perform a broad range of complex, precise and minimally invasive surgeries.

But we can do more. With your investment, our neuroscientists and geneticists can combine their expertise with that of our renowned clinical leaders in neurosurgery, neurology, epilepsy and neurocritical care to cure neurologic disorders.

Committed to Research Our unique research program, the Center for Integrative Brain Research, is committed to breakthroughs in epilepsy research and treatment. We see a future where our experts could take a sample from every patient with epilepsy, identify the specific genetic difference causing seizures and create a personalized therapy based on

their genetic diagnosis. All steps — identifying the genes involved, understanding how gene abnormality causes seizures and planning specific treatments that will stop them — require an integrated team of clinicians and scientists.

This highly personalized early intervention has the potential to change the course of a child’s brain development — and their life.

Our work centers around the whole child, not just their seizures. We want to ensure a child’s success in school, prevent memory problems and avoid depression. Our research center synthesizes the collaborative insights of nearly 70 scientists and physicians, integrating dozens of specialties: Genetics. Psychiatry. Molecular biology. Developmental biology. Electrophysiology. Biochemistry. Neurology. Neurosurgery. Neonatology. Pulmonology. Cardiology. Oncology. Endocrinology. And many more.

You can partner with us to ensure access to early intervention and expert care today, while supporting the development of revolutionary treatments and cures that care for the whole child.

“ We were very blessed that Lillee was a candidate for surgery and we had the level of expertise at Seattle Children’s right in our backyard.” — Aimee Haynes


Success for Epilepsy, Success for all DisordersIt’s audaciously ambitious, our scientists’ quest to unlock exactly how epilepsy affects the brain today and a child’s life into the future. And it’s working: all based on brain mechanisms. We’ve discovered that one of epilepsy’s specific pathways can be cured — not simply treated but cured — by an existing cancer medication. Now we’re poised to demonstrate that discovery’s safety and effectiveness in kids. With your support, we could launch clinical trials immedi-ately. Yet we would still just be scratching the surface for kids with epilepsy: one pathway, one mechanism, one type of epilepsy.

You can ensure this potential cure for a child’s epilepsy — an existing drug’s ability to impact a specific brain mechanism — does not become a one-off success. With significant philanthropic investment, we could apply this approach to other pathways for epilepsy. We could stop

treating the seizures — the symptoms — and start treating the mechanisms behind them. We could also take it a step further: by under-standing the specific pathways and mechanisms involved with epilepsy, we could predict if a child is more likely to experience a related mental health condition like depression.

Advances in epilepsy are just the beginning. Disorders and diseases are more interrelated than anyone previously realized. A cure for one disease can become a treatment for another. A mechanism behind one disease could be the mechanism causing another.

We want to apply the same personalized approach that is successful with epilepsy to other brain disorders — all we need is you.

Lillee Haynes had two brain surgeries before her seizures stopped. We see a future where kids like Lillee won’t need brain surgery to treat their epilepsy.


Imaginative and entrepreneurial thinking is what sets Seattle Children’s apart. With your partnership, we will push the boundaries of research, reshape pediatric medicine and restore hope where there was none.


By diagnosing autism and starting intervention earlier, can we dramatically improve children’s lives?

Personalized Medicine for Kids With Autism:Fueling Growth, Increasing Access, Funding Research.

To better diagnose and treat children with autism, we need to understand the underlying cause. The challenge is that autism, like epilepsy, is a spectrum of disorders with different causes and pathways. Kids need personalized treatment to thrive. That’s why our research focuses on the specific brain mechanisms and genetics behind autism.

Sparking DiscoveriesOur Autism Center is a key partner in the nation-wide SPARK study, which aims to collect DNA samples from 50,000 families. Because of our strong engagement with patient families — and the high trust we’ve established — our patients’ participation rates in this research are among the nation’s highest. By shedding light on how genes affect autism, this research also helps point the way to better treatments.

While genetics is critical to understanding the source of a child’s autism, it is not the only factor. If you’ve met one child with autism — you’ve met one child with autism. Every child is different and, while they may have an autism diagnosis in common, their symptoms, behaviors and needs vary. Integrating clinical research into care at Seattle Children’s Autism Center is essential to understanding how kids respond to therapies, services and other interventions.

Community NeedSince opening its doors in 2009, the Autism Center has become a national model for effective treatment and pioneering research. It is also a vital resource for families throughout the Pacific Northwest. We are the only program in our region that provides uncompensated care:

After learning that their three-year-old twins were on the autism spectrum, Lisa Chiang and her husband sought resources at Seattle Children’s Autism Center. After three years of life-skill classes and therapies the girls are thriving.

YES


diagnosis and treatment regardless of a family’s ability to pay. However, we cannot meet the vast need for our services.

On any given day, hundreds of families are awaiting diagnostic evaluations at the Autism Center. And the list gets longer: we receive nearly 180 referrals each week. Our patient load has doubled since we opened, and patient visits have increased sevenfold, totaling 20,000 annually. The wait for treatment — sometimes up to a year — can be agonizing, especially for parents with a child who’s losing language, who’s no longer responding to her name, who’s not making eye contact, who’s experiencing escalating outbursts.

Opening the Autism Center and its tremendous growth was made possible by philanthropy. As we look to the future of care for kids with autism, we again turn to people like you as our partners.

Early Intervention, New Trajectories We need to expand our capacity because early intervention can change a child’s developmental trajectory in profoundly positive ways. That’s because early intervention can have a direct impact on a child’s brain development. Imagine a child with language deficits. He may be unable to let you know simple things, like what he’d like to eat or what hurts. However, with early and intensive therapy, his communication improves, which then reduces challenging behaviors and enhances his ability to learn.

Our Early Intervention Program is an intensive outpatient program for kids up to age 6 who have significant communication and behavioral challenges. It is also unique in that it delivers

extensive education to parents, helping them communicate with their children and empowering them to be advocates. Philanthropy allows us to continue and expand this transformative program. Resources for Kids and ParentsOur Family Resource Team works closely with families to provide education, referrals and support at every stage. This team is life-changing for families, teaching skills that help them turn activities that are overwhelming into routine family life: Shopping for groceries. Going to the dentist. Getting a haircut. They also help families navigate major life milestones, such as starting school and transitioning to adulthood.

However, our services don’t end when adult-hood begins. Our Alyssa Burnett Adult Life Center offers year-round classes and activities to help participants build on strengths, increase confidence, foster social skills and promote independence. These services are a lifeline for young adults with autism, who can otherwise withdraw after the routine of school ends — increasing the risk of mental and behavioral health issues such as anxiety or depression. The center provides a place to build skills and friendships.

Autism can be one of the most challenging, life-altering neurological conditions families face. Your support is vital to expand access and support research for personalized diagnoses and treatments.

When we started three years ago, they couldn’t walk down the hall at the center to a Halloween party, and now my girls are memorizing lines and performing on stage in front of audiences. My girls are testimonies for why early intervention is critical.

— Lisa Chiang


By understanding the root cause of brain tumors, can we develop person-alized treatments and make surgery less necessary — even obsolete?

Revolutionizing Treatment for Kids With Brain Tumors:The Interactions Between Brain Tumors, Brain Development and Genetics.

Brain tumors are complex, and they’re cruel. First, they’re more common in kids than adults. Second, as a child’s brain develops, a brain tumor interacts with brain development — making them incredibly difficult to treat.

We’re working to revolutionize how brain tumors are treated by identifying the underlying molecu-lar basis — the genetic cause — of a tumor, which can guide more effective, personalized treatments for kids. We’re also working to make brain surgery more precise and less invasive — even obsolete.

Complexities of Brain Tumors Each child’s brain tumor is genetically unique, and it changes over time through its interactions with brain development. As its interactions with

the brain increase, the risks of surgery rise exponentially. And depending on where the tumor is located, surgery may not be an option at all.

Brain tumors are also devious — and smart. There are invading cells outside of the tumor itself, making it nearly impossible to surgically remove the entire tumor. As if this wasn’t enough, they also reprogram a child’s brain and immune system to protect the tumor and allow it to grow.

New Hope From Personalized MedicineThis is where personalized medicine — supported by people like you — comes in. We must invest in research to understand both the molecular basis of brain tumors and how tumors interact with a child’s brain and immune system. This

Liesel Von Imhof came to Seattle Children’s from her home in Anchorage after learning the reason for her migraines: a tumor the size of a ping pong ball in in the middle of her brain.

YES


understanding will guide our development of personalized treatments and help predict out-comes — things like whether surgery will be effective or whether a child is likely to develop a related brain disorder such as epilepsy.

Fighting Complexity With CollaborationRevolutionizing brain tumor treatment is natural for Seattle Children’s. Our neurology and neuro-surgery programs are ranked #1 in the Pacific Northwest. We have more neurosurgeons, and perform more complex neurosurgeries, than any other children’s hospital in the region.

We combine our strengths in research and clinical specialties — radiology, oncology, surgery, psychiatry, endocrinology, ophthalmology and social work — to provide world-class care. With your help we will further invest in research and collaborate across disciplines — relentlessly — until we radically change how brain tumors are treated.

Precise Surgeries, Full LivesAs our research makes strides toward personal-ized treatments guided by genetics, our clinicians also work to make brain surgery more precise than ever before.

Techniques like real-time MRI imagery and laser ablation surgery are far less invasive and far quicker to recover from than traditional surgery. One of our physician-scientists is leading the development of tumor painting, revolutionary imaging that causes tumor cells to fluoresce. The technique, now undergoing clinical trials at Seattle Children’s, allows neurosurgeons to see and remove brain tumors completely — without harming nearby healthy tissue.

Functional MRIs allow us to understand how surgery could affect movement and language, but we can’t yet assess its impact on things like depression or memory loss. Advancements in imaging could allow us to look at a brain tumor in new ways, ultimately answering the question: Will the tumor — or the surgery — have cognitive effects on a child? Philanthropy allows us to take strides toward more precise surgery today while moving toward a future where surgery is unnecessary.

A Future Without Surgery Looking ahead, we envision a future in which even laser ablation and tumor painting become unnecessary because we’re able to reprogram a child’s own immune system to fight brain tumors. We’ve already demonstrated astonishing progress in harnessing immuno-therapy to treat leukemia, with clinical trials achieving initial remission rates as high as 93%.

With further support from philanthropy, we’ll expand our research and clinical trials, finding ways to deliver immunotherapy to destroy brain tumors. This work — a partnership between neurosurgeons, neuroscientists, oncologists and cancer researchers — could be truly game-changing for kids with brain tumors.

Philanthropy has the power to transform brain tumor surgery. We won’t rest until we’re on the verge of putting our brain surgeons out of work. And our surgeons are leading the way, striving to make themselves obsolete.

How long does it take to recover from brain surgery? What does “recovery” really mean? Would I be the same as before, or to what degree would I be different? These were the many questions swirling around in my mind on July 12, 2016, when I sat next to my pale-faced mother in the hospital as we learned I had a brain tumor.

What I discovered is that there are levels in recovering from brain surgery. For example, some short-term memory loss from surgery still remains. As I look back on my journey, I realize I have learned a lot and it has made me a more empathetic person. I have been deeply humbled and have become more grateful.

— Liesel Von Imhof, who now attends college at Harvard


Can we use Big Data to protect developing brains — by driving discoveries and transforming critical care here and everywhere?

Mining Big Data:Setting a New Gold Standard in ICU Care.

Kids are remarkably resilient. Of the critically ill and injured children we treat, nearly all — around 95% — survive. Despite world-class care from our physicians and nurses, children who have had any type of critical illness such as sepsis, cardiac arrest or cancer may be left with lifelong neuro-logical complications. It’s time to do something different — something transformative.

Using Big Data to Drive Innovations in CareWe’re committed to transforming care for criti-cally ill children. How will we do it? By applying predictive analytics, machine learning and data science to the vast amounts of data being collected right now in ICUs.

Currently, this data isn’t being leveraged as it could be to inform — and transform — patient care. Seattle Children’s unique combination of resources and expertise (including both our

clinician experts in neurology, neurosurgery, epilepsy, critical care and neurocritical care and our data scientists) could change that — with you alongside us.

Healthy Brains, Healthy LivesWith your support of our visionary new initiative, we’ll use these tools to analyze data in real time (in urgent life-or-death time) and use it at the bedside to protect kids against seizures, strokes, brain swelling and other dangerous, damaging complications.

The potential benefits for children in the hospital right now are immense. For instance, every seizure we prevent is a victory: we protect brain functioning, we keep scar tissue from forming, we avert a potential heart attack, we improve a child’s ability to learn and socialize, we reduce the likelihood of depression.

Collecting and analyzing data on a national scale will allow us to find patterns that help us develop more precise and personalized care for critically ill patients so they can live life to their full potential after they leave the hospital.

YES


Our innovative Big Data initiative will save lives here in Seattle and could transform medical care everywhere.

And because we don’t end care when kids are discharged, we’ll follow a child’s recovery to improve their long-term outcome. We want to be there to help a child and family navigate a potential neurological condition post-critical care — epilepsy, cognitive impairment, mental health problems — and be able to apply learnings to help future patients.

Big Data and Precision MedicineCollecting, integrating and analyzing ICU data is vital to helping critically ill children go on to lead full lives. It’s also only the beginning of our vision — and of our need for philanthropic support.

Your philanthropic investment will create the infrastructure needed to collect and integrate high volumes of streaming data in entirely new ways: from EEGs, from heart and breathing monitors, and from near-infrared spectroscopy, a non-invasive technique that measures oxygen levels in brain tissue. This infrastructure will allow physicians to access the data in real-time, as well as measure the impact of ICU care on long-term outcomes and use these data to change how we care for all kids in the ICU.

Looking to the future, your backing could take our Big Data initiative even further by supporting our efforts to incorporate genomic data. For example, when we’re caring for a child in the ICU with epilepsy, genomic data could tell us

what specific form of epilepsy that child has. It could then tell us that this form of epilepsy is caused by the same brain mechanism that causes autism or depression, guiding our predictive, personalized care for that child.

You can connect our ICU Big Data initiative to our expertise in genetics — a powerful combina-tion that will design precision therapies for kids in the hospital now and ultimately transform critical care for kids everywhere.

Big Data takes big investments. But it also has immense returns. We invite you to be part of driving neuroscience discoveries and clinical-care breakthroughs — giving kids their best chance to heal completely and go on to live healthy, happy lives.


Join Us: Say YES to Personalized Medicine for Kids With Brain DisordersSeattle Children’s is starting a research revolution. Our multidisciplinary, integrative research is unlocking the complex causes of brain disorders and catalyzing paradigm shifts in how we diagnose, treat and prevent them.

This research revolution is poised to transform childhood brain health. And philanthropy is critical.

The funding need is specific, and it’s vast. It’s also not well funded by the government or the pharmaceutical industry. Childhood brain disor-ders are far more complex and individualized than adult disorders. And any disruption in a child’s rapidly developing brain can potentially change the entire trajectory of their life far beyond medical care: how they communicate, how they learn, whether they experience anxiety or depression.

Harnessing our progress in genetics to develop personalized therapies across all neurological

conditions will be a world-changing breakthrough. But first it requires stable, long-term funding. It requires philanthropy. It requires you.

Philanthropic investment will accelerate our research revolution and bring about a future in which we can approach brain disorders in radical new ways. A future in which epilepsy is controlled or even cured. A future in which we offer more effective autism treatments, specific to each child, and no family has to wait for services and care. A future in which a child with a brain tumor never needs an invasive surgery. A future in which patterns found in Big Data allow for real-time decision-making at the bedside. A future where personalized, early intervention for a child with a neurological disorder has changed the course of their life.

To create the healthy future we envision — where every child with a brain disorder is thriving — philanthropy is essential.


Funding Opportunities

Philanthropy will change the lives of patients and their families through the promise and potential of personalized medicine. In the process, you can transform brain-related research and care around the world. How? By supporting initiatives to:

• Strengthen and expand our visionary, multi-disciplinary work at the Center for Integrative Brain Research — and transform discoveries into precision medicine for our patients. Seattle Children’s integrated research-to-care and care-to-research model is one of our great strengths, positioning us for national and global leadership in developing new treatments for epilepsy, autism, brain tumors, behavioral disorders and other neurological issues.

• Spark paradigm-shifting research breakthroughs. Philanthropy holds the key to pursuing creative outside-the-box ideas that are critical to our research revolution and will take us down unexpected new paths, such as our discovery that a cancer-treatment drug can cure one form of epilepsy. Your generous support can play a vital role in sparking game-changing discoveries that reveal the root causes of diseases and disorders.

• Expand patient access, family support, research, and staffing at the Autism Center. Philanthropic support will allow our scientists to unravel the causes and mechanisms of autism spectrum disorders, paving the way for personalized treatment. Much of the Autism Center’s work — especially components that make it a national model for effective, compassionate care — goes above and beyond what’s covered by insurance. Philanthropy is a lifeline, helping us empower kids to flourish and families to thrive.

• Recruit, train and retain world-class experts — physicians, surgeons, scientists, psychologists,

and others. Dedicated and brilliant scientists and clinicians are crucial to achieving our goal of advancing treatment breakthroughs and cures that improve the lives of children and families across the region and around the world. Only by attracting superb talent can we remain at the forefront of innovation, now and into the future.

• Create world-class clinical facilities at the new Neurosciences Center. By combining our Neurology and Neurosurgery programs into a seamless whole, the Neurosciences Center will foster collaboration and translate research breakthroughs into rapid advances in care. It will define Seattle Children’s as the nation’s clinical leader, as well as the research leader, in the healthy-brain revolution. Significant philanthropic investment could expand capacity, support state-of-the-art technology and help provide life-changing care to every patient and family.

• Harness the power of Big Data to drive care and research breakthroughs. Capturing data in critical care settings and combining it with our expertise in genetics will ultimately allow us to prevent brain injuries in kids. Your invest-ment in this data science initiative supports our critically ill patients today and furthers research that will change how we care for all children with neurological disorders.


We invite you to join us and say yes.

Yes to a family who needs access to expert care today. Yes to preventing disease before a child suffers.

Yes to providing all families innovative and less-invasive treatment options. Yes to new hope and healthier futures for kids with brain disorders.

It Starts With YES.


Total Campaign Goal: $1 Billion

It Starts With YES — The Campaign at a Glance

Advancing Our Core Mission to

Care for Every Child

Delivering on the Power and Promise of Immunotherapy

Unlocking the Mysteries of the Developing Brain

Launching a New Era for Community Health

and Wellness

Ensuring families can count on us today and always through legacy gifts

Seattle Children’s Hospital and Research Foundation6901 Sand Point Way NESeattle, WA 98115TEL 206-987-2153

www.seattlechildrens.org

© 2018 Seattle Children’s, Seattle, Washington. All rights reserved.

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