University of Groningen

Intravenous drug dose optimization and drug effect monitoring in anaesthesiaSahinovic, Marko

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.

Document VersionPublisher's PDF, also known as Version of record

Publication date:2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):Sahinovic, M. (2017). Intravenous drug dose optimization and drug effect monitoring in anaesthesia.[Groningen]: Rijksuniversiteit Groningen.

CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.

Download date: 25-05-2020

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 147PDF page: 147PDF page: 147PDF page: 147

147

DankwoordList of publications

Curriculum Vitae

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 148PDF page: 148PDF page: 148PDF page: 148

148

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 149PDF page: 149PDF page: 149PDF page: 149

149

DankwoordDit proefschrift had niet tot stand kunnen komen zonder hulp van mensen om mijn heen. Hierbij wil ik iedereen bedanken. Het is een illusie te denken dat ik iedereen bij naam kan noemen. Echter sommigen hebben een bijzondere indruk achtergelaten. Ik wil de volgende personen in het bijzonder bedanken.

Mijn promotorenProf. dr. A.R. Absalom; Tony. Ik wil je bedanken dat je er altijd bent. Door jouw steun en samenwerking door dik en dun heb ik dit traject succesvol kunnen afronden.

Prof. dr. M.M.R.F. Struys; Michel. Bedankt voor het vertrouwen. Jij hebt mij de kant van de wetenschap op gestuurd en onderweg altijd gesteund en aangemoedigd.

Mijn copromotorDr. ir. D. Eleveld; Douglas. Jouw vaardigheid om ingewikkelde dataverwerking moeiteloos laten lijken, je oog voor detail en kritische blik hebben mij veel geholpen.

De leescommissieVoor de bereidwilligheid om dit proefschrift te beoordelen.

Mijn collega’sDe groep onderzoekers binnen de anesthesiologie in het UMCG groeit gestaagd. Veel mensen hebben geholpen bij het tot stand komen van dit proefschrift. Ik wil hierbij iedereen bedanken.

Alain Kalmar en Hugo Vereecke hebben hetzelfde traject nog niet zo lang geleden bewandeld. Zij hebben mij dan ook veel geholpen met het onder de knie krijgen van de fundamenten van het verrichten van onderzoek. Natuurlijk kan ik niet mijn kamergenoten Jaap Jan Vos, Jop van den Berg en Rutger Spruit vergeten. Onze “intercollegiale besprekingen” al dan niet naast het koffieapparaat hebben vaak een andere kijk gegeven op een lastig probleem. Verder wil ik ook de collega’s uit de VS, Australië en Japan bedanken voor hun goede samenwerking. Tot slot kan ik ook de gehele chirurgische en anesthesiologische staf van het UMCG niet vergeten. Jullie begrip en geduld, vooral in de fase van het verzamelen van data, hebben dit mogelijk gemaakt.

Mijn vriendenSamen hebben we heel veel meegemaakt. Onze gave belevenissen op vakanties en verhitte “existentiële” discussies zullen mij altijd bijblijven. Hopelijk blijven we dit altijd doen.

Mijn familieMijn ouders, Jasminka i Ismet Sahinovic. Hvala vam za sve. Vi ste me uvjek staivili na prvo mjesto. Vi ste mi uvjek pomogli kad mi je bilo tesko. Niko nema takve krasne riditelje kao ja.

Tot slot natuurlijk mijn lieve vriendin, Kitty. Bedankt dat je er altijd voor mij bent. Jij geeft kleur aan mijn leven.

Dankwoord

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 150PDF page: 150PDF page: 150PDF page: 150

150

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 151PDF page: 151PDF page: 151PDF page: 151

151

List of publications

List of publicationsStruys MMRF, Sahinovic MM, Lichtenbelt BJ, Vereecke HEM, Absalom AR. Optimizing intravenous drug administration by applying pharmacokinetic/pharmacodynamic concepts. BJA Br J Anaesth 2011; 107: 38–47 Sahinovic MMM, Absalom AR, Struys MMRF. Administration and monitoring of intravenous anesthetics. Curr Opin Anaesthesiol 2010; 23: 734–40

Sahinovic MM, Beese U, Heeremans EH, et al. Bispectral index values and propofol concentrations at loss and return of consciousness in patients with frontal brain tumours and control patients. BJA Br J Anaesth 2014; 112: 110–7

Sahinovic MM, Eleveld DJ, Miyabe-Nishiwaki T, Struys MMRF, Absalom AR. Pharmacokinetics and pharmacodynamics of propofol in patients with frontal brain tumours and control patients. Br J Anaesth 2017; in press

Sahinovic MM, Eleveld DJ, Kalmar AF, et al. Accuracy of the composite variability index as a measure of the balance between nociception and antinociception during anesthesia. Anesth Analg 2014; 119: 288–301

Shoushtarian M, Sahinovic MM, Absalom AR, et al. Comparisons of Electroencephalographically Derived Measures of Hypnosis and Antinociception in Response to Standardized Stimuli During Target-Controlled Propofol-Remifentanil Anesthesia. Anesth Analg 2016; 122: 382–92

1

2

3

4

5

6

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 152PDF page: 152PDF page: 152PDF page: 152

152

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 153PDF page: 153PDF page: 153PDF page: 153

153

Curriculum Vitae

Curriculum Vitae van Marko Mirza Sahinovic

Personalia

Nationality: Dutch Age : 36 years old

Education 2001-2007 University of Groningen Groningen Master’s degree in Medicine, with Honours 1999 - 2001 University of Groningen Groningen Propaedeutic degree in Psychology, with Honours

1993 - 1999 Maartens college Haren High school, gymnasium

Related experience Jun 2016– now: University Medical Center Groningen Anaesthesia Consultant Jan 2016 – May 2016 Cambridge University Hospital Cambridge Clinical fellow in Neuro-anaesthesia Jan 2011 – May 2016 University Medical Center Groningen Anaesthesia resident May 2010 – now: Faculty of 1000 London F1000 prime associate member of faculty Neuro-anaesthesia Jan. 2010 – now: University Medical Center Groningen Research fellowship in Anaesthesia Feb. 2008 – Dec. 2009: University Medical Center Groningen Junior doctor in Intensive Care Oct. 2007 – Feb. 2008: University Medical Center Groningen Junior doctor in Surgery

Publications Comparisons of Electroencephalographically Derived Measures of Hypnosis and Antinociception in Response to Standardized Stimuli During Target-Controlled Propofol-Remifentanil Anesthesia. Shoushtarian M, Sahinovic MM, Absalom AR, Kalmar AF, Vereecke HE, Liley DT, Struys MM. Anesthesia and Analgesia 2016 Feb;122(2):382-92 Accuracy of the composite variability index as a measure of the balance between nociception and antinociception during anesthesia. Sahinovic MM, Eleveld DJ, Kalmar AF, Heeremans EH, De Smet T, Seshagiri CV, Absalom AR, Vereecke HE, Struys MM. Anaesthesia and Analgesia 2014 Aug;119(2):288-301.

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 154PDF page: 154PDF page: 154PDF page: 154

154

Bispectral index values and propofol concentrations at loss and return of consciousness in patients with frontal brain tumours and control patients.Sahinovic MM, Beese U, Heeremans EH, Kalmar A, van Amsterdam K, Steenbakkers RJ, Kuiper H, Spanjersberg R, Groen RJ, Struys MM, Absalom AR. British Journal of Anaesthesia 2014 Jan; 112(1):110-7. Optimizing intravenous drug administration by applying pharmacokinetic/pharmacodynamic concepts. Struys MM, Sahinovic M, Lichtenbelt BJ, Vereecke HE, Absalom AR. British Journal of Anaesthesia, 2011 Jul;107(1):38-47. Administration and monitoring of intravenous anesthetics. Sahinovic MM, Absalom AR, Struys MM. Current opinion in Anaesthesiology2010 Dec; 23(6):734-40 The value of surveillance mammography of the contralateral breast in patients with a history of breast cancer.Lu W, Schaapveld M, Jansen L, Bagherzadegan E, Sahinovic MM, Baas PC, Hanssen LM, van der Mijle HC, Brandenburg JD, Wiggers T, De Bock GH.European Journal of Cancer. 2009 Nov; 45(17):3000-7.

F1000 recommendations Absalom A and Sahinovic M: F1000Prime Recommendation of [Zand F et al., Br J Anaesth 2014, 112(5):871-8]. In F1000Prime, 30 Sep 2014

Absalom A and Sahinovic M: F1000Prime Recommendation of [Shen SL et al., Ann Pharmacother 2013, 47(11):1391-9]. In F1000Prime, 16 Dec 2013

Absalom A and Sahinovic M: F1000Prime Recommendation of [Ní Mhuircheartaigh R et al., Sci Transl Med 2013, 5(208):208ra148]. In F1000Prime, 03 Jan 2014

Absalom A and Sahinovic M: F1000Prime Recommendation of [Aranake A et al., Anesthesiology 2013]. In F1000Prime, 16 Dec 2013

Absalom A and Sahinovic M: F1000Prime Recommendation of [Glen J et al., Br J Anaesth 2013, 111(3):400-5]. In F1000Prime, 02 Oct 2013

Absalom A and Sahinovic M: F1000Prime Recommendation of [Casali AG et al., Sci Transl Med 2013, 5(198):198ra105]. In F1000Prime, 16 May 2014

Absalom A and Sahinovic M: F1000Prime Recommendation of [Purdon PL et al., Proc Natl Acad Sci U S A 2013, 110(12):E1142-51]. In F1000Prime, 29 Jan 2014;

Absalom A, Sahinovic M and Kalmar A: F1000Prime Recommendation of [Salvador L et al., J Neurosurg Anesthesiol 2010, 22(3):240-6]. In F1000Prime, Dec 2010; Absalom A and Sahinovic M: F1000Prime Recommendation of [Friedman EB et al., PLoS ONE 2010, 5(7):e11903]. In F1000 Prime, 13 Aug 2010

Courses followed 2014 University of Groningen Groningen Basic course for Regulatory Organization for Clinical researchers

2013 OSG Nederland Houten Advanced Life Support

July 2009 FCCS Nederland Ede Fundamental Critical Care Course

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 155PDF page: 155PDF page: 155PDF page: 155

155

Curriculum Vitae

Jan. 2009 ATLS Nederland Riel Advanced Trauma Life Support

Teaching experience 2006-2007 and 2011 University of Groningen Groningen Tutor to undergraduate Medical students in General medicine

2002 and 2003 University of Groningen Groningen Tutor to undergraduate Medical students in Human anatomy and dissection

Languages Serbo-Croatian – Native speaker Dutch – Speak fluently and read/write with high proficiency English - Speak fluently and read/write with high proficiency German – Speak, read and write with basic competence

509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovic509881-L-bw-sahinovicProcessed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017Processed on: 1-5-2017 PDF page: 156PDF page: 156PDF page: 156PDF page: 156

156