CURRICULUM VITAERICHARD L. HUGHES, M.D.

Professor of Neurology 12401 East Seventeenth Avenue, Mail Stop L950

Aurora, CO 80045720. 848.2080 (Clinic)

720.848.0194 (Fax)richard.hughes@ucdenver.edu

BIOGRAPHY:Birth Date: June 5, 1955

Birthplace: Rumford, Maine

EDUCATION AND EXPERIENCE:1972 - 1973 New Mexico Highlands University, Las Vegas, New Mexico

1973 - 1976 B.A. Chemistry University of New Mexico, Albuquerque, New Mexico

1978 - 1982 M.D. University of New Mexico School of Medicine, Albuquerque, New Mexico

1982 - 1983 Intern, Medicine and Psychiatry University of New Mexico, Albuquerque, New Mexico

1983 - 1986 Resident in Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania

1986 – 1987 Clinical Fellow in Cerebrovascular Disease, University of Colorado, Denver, Colorado

ACADEMIC APPOINTMENTS:1987 - 1991 Ochsner Clinic, Tulane University Medical School Rehabilitation Unit

New Orleans, Louisiana, Staff Neurologist - General Partner Department of Neurology, Clinical Assistant Professor of Neurology

1991 - 2016 Denver Health Medical Center, University of Colorado School of MedicineDenver, Colorado, Division of Neurology (Chief 1995), Professor of Neurology (2008)

2016-Present University of Colorado Anschutz Medical Campus, Professor of Neurology

HONORS, SPECIAL RECOGNITIONS AND AWARDS:1995 Outstanding Teacher of the Year, University of Colorado, Department of Neurology

Resident Class of 19951997-1998 Excellence in Teaching Award, University of Colorado, Department of Neurology1998-1999 Excellence in Teaching Award, University of Colorado, Department of Neurology1999-2000 Excellence in Teaching Award, University of Colorado, Department of Psychiatry2000 American Heart Association, Robert Ginsberg Medical Volunteer of the Year 2001 7th Annual Outstanding Clinician Award, Denver Health Medical Center2003 Outstanding Teacher of the Year, University of Colorado, Medical School Class of 20032003 “Mr. Smooth Award”, University of Colorado, 2003 Residency Class2003 American Heart Association, Advocate of the year-Colorado2007 Nominee, University of Colorado Teaching Excellence2008 Nominee, University of Colorado Teaching Excellence

2003-2006 Best Doctors 2003-2006 and 2009-2016. "Selected by his peers for inclusion in Best 2009-2016 Doctors in America® from 2003 to 2006 and 2009 to 2016."

MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS: American Medical Association FellowAmerican Academy of Neurology FellowStroke CouncilAmerican Heart Association North American Neuro-Ophthalmology Society Colorado Society of Clinical NeurologistsColorado Acute Stroke Network (Co-Founder)

MAJOR COMMITTEE AND SERVICE RESPONSIBILITIES1993-1995 President, Colorado Society of Clinical Neurologists1995-1996 Secretary-Treasurer, Denver General Hospital2000-2003 University of Colorado School of Medicine Faculty Senate 1996-2002 Rocky Mountain Stroke Association (Board)2002-present Colorado Department of Public Health and Environment Stroke Advisory Committee 1997-present American Heart Association, Denver Board 1999-2002 Co-Chair, Denver Operation Stroke, American Stoke Association, 1998-2002 Chairman, AHA Desert Mountain Affiliate Stroke Advisory Committee 2000-2003 American Heart Association Desert-Mountain Affiliate Board, 2002-2006 American Heart Association Pacific Mountain Affiliate Stroke Committee 2001-2004 American Stroke Association Advisory Board, 2002-2011 ASA/JCAHO Primary Stroke Center Certification Committee 2005-2011 ASA/JCAHO Comprehensive Stroke Center Certification Committee 2006-2008 AHA PMA Strategic Planning Committee 2009-2012 University of Colorado School of Medicine Promotions Committee, Co-Chair 20122012-2015 AHA Hospital Certification Science Committee

LICENSURE AND BOARD CERTIFICATION:Pennsylvania (Inactive) MD-030075-EBureau of Professional and Occupational Affairs P.O. Box 2649, Harrisburg, PA 17105-2649

Louisiana (Inactive) 07604RLouisiana State Board of Medical ExaminerP.O. Box 30250, New Orleans, LA 70190-0250

Colorado (Active) 0027568Board of Medical Examiner1560 Broadway, Denver, Colorado 80202-5140

LOBBYING:Washington DC: 1995, 2000, 2002 with the American Academy of Neurology, The American HeartAssociation and the Colorado Society of Clinical Neurologists.

COLORADO STROKE BILL:This legislation was written by Jack Pommer then aid to Boulder House Representative Todd Saliman, and the AHA Desert Mountain Affiliate Stroke Committee (Chair, RL Hughes, MD) and passed in March 2002 by both the Colorado House and Senate after testimony by Dr. Richard Hughes among others.

Governor Bill Owens signed the bill into law in May 2002. This legislation has set up a statewide advisory board on stroke policy through the Colorado Department of Public Health and Environment, now the Colorado Stroke Alliance. There is now a Stroke Registry in Colorado, including the University Hospital and Denver Health Medical Center.

PRIMARY STROKE CENTER CERTIFIATIONS:The JCAHO Disease specific certification process has partnered with the ASA, via the ASA Advisory Committee (RL Hughes, MD, member) and the ASA Primary Stroke Center Certification Sub- Committee (RL Hughes, MD, Member). This certification has begun, and is the most requested certification of the JCAHO programs.

COMPREHENSIVE STROKE CENTER CERTIFICATION:In the summer of 2005, the Comprehensive Stroke Center guidelines were published and the ASA committee for CSC was formed (RL Hughes, MD, Member). Drs. Richard Hughes and Anthony Furlan have presented their analysis of what key factors constitute a CSC and distinguish the CSC from a PSC. These recommendations will be carried forward with other specialty organizations.

BOARD EXAMINERNational Board of Medical Examiners, Parts I, II, III Neurology Board Certified 1988Diplomat, Vascular Neurology 2005Neurology Board Examiner (1990, 95, 99, 00, 00, 01, 01, 03)

REVIEWER: Stroke Journal of Neuro-Ophthalmology National Stroke Association The NeurologistJournal of Stroke and Cerebrovascular DiseaseInternational Journal of StrokeCirculation

INVITED EXTRAMURAL LECTURES, PRESENTATIONS AND VISITING PROFESSORSHIPS:WSSC Western States Stroke ConsortiumNATIONAL AND REGIONAL INVITED SPEAKINGDATE: LOCATION: TOPIC: COURSE:March 2016 Kona, HI Neurology Updates for

Internists Stroke: Headache Vertigo; Neuropathic Pain

February 2016 Beaver Creek *Co-Director Neurosurgery of the RockiesFebruary 2016 Beaver Creek NIH IRIS TrialFebruary 2015 Beaver Creek *Co-Director Neurosurgery of the RockiesFebruary 2015 Beaver Creek Updates in Stroke 2015February 2014 Beaver Creek *Co-Director Neurosurgery in the RockiesOctober 2013 Princeville, HI Neurology for the PCP Series of four talksFebruary 2013 Beaver Creek *Co-Director Neuro surgery in the RockiesOctober 2012 Comprehensive Stroke Western States StrokeJune 2012 Estes Park Neurology Update Family Medicine ReviewFebruary 2012 Beaver Creek Stroke Call Fleming SyndromeFebruary 2012 Beaver Creek *Co-Director Neurosurgery in the Rockies

July 2011 Estes Park Neurology Update Internal Medicine ReviewFebruary 2011 Beaver Creek *Co-Director Neurosurgery in the RockiesSeptember 2010 Denver Stroke Internal MedicineSeptember 2010 Albuquerque, NM Comprehensive Stroke WSSCFebruary 2010 Beaver Creek *Co-Director Neurosurgery in the RockiesJuly 2009 Estes Park Stroke Update Internal Medicine ReviewJune 2009 Estes Park Seizures Family Medicine ReviewNovember 2008 Denver Stroke Update Family Medicine ReviewOctober 2008 Boulder Atherosclerosis AHA Prevention SeriesJune 2008 Estes Park Stroke Update Family Medicine ReviewFebruary 2008 Beaver Creek *Co-Director Neurosurgery in the RockiesNovember 2007 Denver Stroke Update Family Medicine ReviewJune 2007 Estes Park Stroke Update Internal MedicineMarch 2007 Denver Health Intracerebral Hemorrhage CME CourseFebruary 2007 Vail Statins in Cerebrovascular

DiseaseFebruary 2007 Vail *Co-Director Neurosurgery in the RockiesOctober 2006 Barrow Neurological

Institute, PhoenixSpeaker

April 2006 Denver Stroke in Women Go Red for WomenFebruary 2006 Vail *Co-Director Neurosurgery in the RockiesFebruary 2006 Breckenridge CSC in USA Vista InvestigatorsFebruary 2006 Denver Stroke in Women CV Summit for WomenFebruary 2006 Vail Neurological injuries Neurology RetreatApril 2004 Denver AJA/JCAHO Stroke UpdateJanuary 2004 Portland, OR ASA/JCAHO Stroke CenterJanuary 2004 Montrose Stroke Update UCHSC OutreachOctober 2003 Denver Hypothermia DHMC ICUSeptember 2003 Denver Stroke UCHSC UCHSC RehabilitationApril 2003 Denver Stroke UCHSC CardiologyDecember 2002 Denver Stroke Neurology Journal ClubDecember 2002 Denver Stroke UCHSC OB/GYNSeptember 2002 Los Angeles Stroke Legislation WSSCSeptember 2002 Estes Park Stroke Workshop AHA/ACLSSeptember 2002 Estes Park ACLS-Stroke AHAApril 2002 Denver Update ASA SeminarFebruary 2002 San Antonio, TX ASA/ISM Annual ASA UpdateJune 2001 Denver Stroke Imaging ACVIMJune 2001 Kona, HI Stoke Volunteer TTESMay 2001 Littleton Stroke Update RMSANovember 2000 Boulder Stroke Prevention PanelOctober 2000 Estes Park Operation Stroke AHASeptember 2000 Aspen Operation Stroke WSSCSeptember 2000 Denver Stroke Update RMSAAugust 2000 Denver Stroke Family MedicineAugust 2000 Denver Brain Localization NeuropaychAugust 2000 Denver Stroke Update Lutheran

August 2000 Meeker Stroke Resuscitation CASN/AHAJuly 2000 Estes Park Stroke Update Internal MedicineJune 2000 Bryn Mawr, PA Stroke Outcome RehabilitationMay 2000 Phoenix, AZ Stroke Resuscitation AHAMarch 2000 Aspen Stroke Resuscitation CASN/AHANovember 1999 Denver Operation Stroke AHA BoardOctober 1999 DHNC Stroke Resuscitation Medicine Research September 1999 Snowmass Atrial Fibrillation NSA SeminarJuly 1999 Aspen Thrombolytic UC-CMEMarch 1999 Snowmass *Session Co-Chair NANOSJanuary 1999 DHMC Migraine Emergency MedicineOctober 1998 Denver Stroke Success RMSASeptember 1998 Los Angeles, CA CASN RMSAMay 1998 Denver *Anti-Thrombotic

TherapyCourse Director

April 1998 Ft. Lauderdale, FL Stroke Resuscitation NSA SeminarFebruary 1998 Jackson, WY Stroke St. John’s HospitalFebruary 1998 Denver Stroke UC-CMENovember 1997 Denver Carotid Disease Vascular Grand RoundsOctober 1997 Denver Stroke Resuscitation AAN SeminarOctober 1997 Boise, ID Stroke Resuscitation NSA SeminarOctober 1997 Colorado Springs Headache Military PhysiciansAugust 1997 Albuquerque, NM Stroke Resuscitation Neurology Grand RoundsAugust 1997 Denver Carotid Disease Medicine Grand RoundsJuly 1997 Denver Reperfusion Injury Grand RoundsJune 1997 Evanston, WY Thrombolytics CASN/AHA SeriesMay 1997 Riverton, WY Thrombolytics CASN/AHA SeriesMay 1997 Lander, WY Thrombolytics CASN/AHA SeriesMay 1997 Denver CASN CASN TeleconferenceMarch 1997 Denver Stroke Resuscitation St. Joseph’s Grand RoundsFebruary 1997 Cody, WY Thrombolytics CASN/AHA SeriesFebruary 1997 Jackson, WY Thrombolytics CASN/AHA SeriesJanuary 1997 Vail Thrombolytics Emergency MedicineDecember 1996 Cheyenne, WY Thrombolytics CASN/AHA SeriesNovember 1996 Farmington, NM Thrombolytics in Stroke CASA/AHA SeriesOctober 1996 Casper, WY Thrombolytics in Stroke CASN/AHA SeriesOctober 1996 Denver Stroke Medicine CPCJuly 1996 Estes Park Stroke Resuscitation IM Review CourseJune 1996 Colorado Springs *Session Co-Chair NSA-North AmericanMarch 1996 Denver Stroke Geriatric Course January 1996 Denver Headache and Epilepsy SeminarJune 1995 Denver *Session Co-Chair NSA SeminarSeptember 1994 Denver Stroke Colorado NursingJuly 1994 Marshfield, WI FMD Clinical Grand RoundsApril 1994 Palm Springs, CA Stroke NSA SeminarMarch 1994 Breckenridge Stroke Geriatric Review CourseJanuary 1994 Denver Stroke Fitzsimmons

July 1993 Estes Park Stroke IM Review CourseApril 1993 New Orleans, LA Carotid Disease Ochsner CourseJanuary 1993 Loveland Stroke McKee Medical CenterJuly 1992 Denver Keynote Address Rehabilitation SeminarMay 1992 Denver Thrombolytic Therapy CSCNMarch 1992 Winter Park Stroke GeriatricNovember 1990 New Orleans, LA Stroke GeriatricSeptember 1990 New Orleans, LA Resuscitation Tulane NeurologyApril 1990 New Orleans, LA FMD Tulane NeurologyFebruary 1990 New Orleans, LA Atypical TIA Vascular Surgery

International Speaking InvitationsDATE: LOCATION: TITLE:December 2016 Nassau, Bahamas Neurology Selected TopicsFebruary 2015 St. Martin Neurology Selected TopicsOctober 2006 Stroke Society of Australasia,

AdelaideComp Stroke Certification

May 2006 University of Heidelberg, Germany Visiting ProfessorSeptember 2002 Stroke Society of Australasia,

QueenslandStroke Panelist / North America

December 2001 Train to End Stroke, Jamaica Speaker / ChairOctober 1998 Boehringer-Ingelheim, Crete Advisory PanelSeptember 1994 Janssen, Toronto, Canada Stroke ResuscitationJuly 1994 HCI, Glasgow, Scotland Visiting Professor

Recent University of Colorado Grand Rounds:The Emerging use of Statins in Cerebrovascular Disease Carotid Endarterectomy: An Emerging Consensus Fibromuscular DysplasiaPolycystic Kidney Disease and Intracranial AneurysmsCNS Vasculitis Thrombolytic Therapy in Acute Stroke New Directions in Stroke ResuscitationAre You Ready for Combination Therapy?Unruptured Intracranial AneurysmsIatrogenic Complications of Stroke TherapyAdvocacy, Lobbying, and the 2002 Colorado Stroke Bill

Recent University of Colorado Grand Rounds cont:The Spectrum of Moya-Moya Disease in the AdultAre You Ready For Stroke Center Certification?Stroke Retrospective 1986-2006Susac’s SyndromeCall FlemingReducing Cardiac Embolization to the Brain: Are we getting near the finish line?Insulin Resistance in Stroke Prevention: The NIH IRIS Trial Results

Regular Conferences/Talks:MS2 Neuropathology Course, UCSOM Acute Neurology Series, UCHSOMStroke Update for Internal Medicine, UCH & DHMC

MS4 Pharmacology, UCSOM (winter)Residency Core Topics, UCSOM (on-going)Stroke Fellow Weekly Core Lecture Series

MEDIA:DATE: MEDIUM: TOPIC:2010 Channel 31 Fox – Kim Posey Meningitis2009 Fitness Magazine Fibromuscular Dysplasia2007 Stroke Connection Fibromuscular Dysplasia2004 Channel 31 Fox – Kim Posey “Brain Matters”2004 Rocky Moun6tain News Migraines2001 Bottom Line “Stroke Self-defense”2001 Channel 2 “Hyperbaric Oxygen in stroke”2001 KUSA TV “Train to End Stroke”2000 KUSA TV “Operation Stroke”2000 NSA Audio Tape and CD Stroke Guidelines1999 KUSA Radio Atrial Fibrillation1999 Fox Television News Hypothermia1999 Bottom Line Magazine Atrial Fibrillation1999 Tomorrow Magazine Atrial Fibrillation1999 Bottom Line Magazine Facial Tics1999 Stroke-CD NSA1999 USA Today Stroke Prevention1999 NSA Video Stroke1998 Prevention Magazine Atrial Fibrillation1998 NSA-SCN-Audio Teleconference Moderator1997 KUSA TV “Taco Neck”1997 KUSA TV “Pokeman” Induced Seizures1997 Internal Medicine News Minimum Requirements for TPA use1997 Boulder Daily Camera Stroke1996 Denver Post Aneurysm1996 AARP Video Stroke1993 National Stroke Association, 1994

20 minute videoStroke: The Story of Treatment and Recovery. A 20 minute video, discussing aspects of treatment and prognosis after a stroke. Featuring Dr. Richard Hughes, and stroke-survivor Jackie Meyer-Townsend, Miss America 1963

STUDY CONSULTING:Amgen: Data Management and Safety Committee. Stem Cell treatment after Stroke 2010-2012Nestle Life Sciences: Advisory Committee. Dysphagia 2015-present.

STUDY PARTICIPATION:Grants and Funding

Funding Source (estimate) Multi-Center Studies

NIH / Yale 2005-2013 Insulin Resistance Intervention after Stroke (IRIS)Richard L. Hughes MD (PI Denver)

NIH ($275,000) Warfarin Versus Aspirin in Reduced Ejection Fraction (WARCEF)2003-2012 Richard L. Hughes MD (PI Denver)

Lilly USA, LLC Duloxetine in Patients with Central Neuropathic Pain in Multiple Sclerosis - Richard L. Hughes MD (PI Denver)

Merck Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRASP)Richard L. Hughes MD (PI Denver)

Boehringer-Ingelheim Prevention Regimen For Effectively Avoiding Second Strokes 2003-2008 ($120,000) (PRoFESS) - Richard L. Hughes MD (PI Denver)

Parke-Davis ($40,000) Stroke Prevention by Aggressive Reduction in Cholesterol levels 1999-2004 (SPARCL) - Richard L. Hughes MD (PI Denver)

Novo Nordisc ($10,000) Factor VII in Treatment of Cerebral hemorrhage (FAST)Richard L. Hughes MD (PI Denver)

NIH ($138,576) Vitamin Intervention in Stroke Prevention (VISP)1998-2004 Richard L. Hughes MD (PI Denver)

Genentech ($60,000 Thrombolytic Therapy in Acute Ischemic Stroke1992-2000 ATLANTIS - Richard L. Hughes MD (PI Denver)

NHI ($20,000) International Study of Unruptured Intracranial Aneurysms (ISUIA)1992-2000 Richard L. Hughes MD (PI Denver)

HCFA $0 Appropriateness of Carotid EndarterectomyRichard L. Hughes MD – Panelist

Jannsen terminated PACT (Prosynap Alteplase Combined Therapy)1997-1999 Richard L. Hughes MD (PI Denver)

ICOS terminated HU23F26 Anti-adhesion to Limit Cytotoxic Injury In Stroke (HALT)Richard L. Hughes MD (PI Denver)

Lorex ($17,000) Eliprodil in Ischemic Stroke (1995-1997)1995-1996 Richard L. Hughes MD (PI Denver)

Santofii ($150,000) Clopidigrel vs. Aspirin in Prevention of Recurrent Ischemic Events1992-1997 (CAPRIE) - Richard L. Hughes MD (PI Denver)

NIH ($12,000) Asymptomatic Carotid Atherosclerosis Study (ACAS)

1989-1991 Ochsner Richard L. Hughes MD (PI New Orleans)

Miles ($55,000) Nimodipine Stroke Study1988-1990 Richard L. Hughes MD (PI New Orleans)

AUTHORED AND CONSORTIUM PUBLICATIONS:1. Hughes RL: Medical overview of brain death. Health Care Review; 3(1):6-9, 1986.2. Rosenberg NL, Hughes RL: Meningovascular Syphilis in a Young Homosexual Man. Arch Neurol 1989; 46:10-11.3. Hughes, RL, Yonas H, Gur D, Latchaw R: Cerebral blood flow determination within the first 8 hours of cerebral infarction using stable Xenon-enhanced computed tomography. Stroke 1989; 20:754-760.4. The Hemodilution in Stroke Study Group. Hypervolemic hemodilution treatment of acute stroke. Results of a randomized multicenter trial using pentastarch. Stroke 1989 Mar; 20(3):317-23. (RL Hughes, Denver)5. Hughes RL, Katirji B: The Eaton-Lambert (Myasthenic) Syndrome in Association with Systemic Lupus Erythematosus.Arch Neurol 43:1186-87, 1986.6. Hass WK, Easton JD, Adams HP, Pryse-Phillips W, Molony BA, Anderson S, Kamm B: For the Ticlopidine Aspirin Stroke Study Group. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high risk patients. NEJM 1989; 321:501-507. (RL Hughes, Pittsburgh and Denver).7. Hughes RL: Identification and treatment of unruptured cerebral aneurysm after sentinel headache. Report of two cases. Neurology 1992; 42:1118-1119.8. Chapman AB, Rubinstein DR, Hughes RL, Stears JC, Earnest MP, Johnson AM, Gabow PA and Kaehny WD: Intracranial aneurysms in autosomal dominant polycystic kidney disease: A prospective study. NEJM 1992; 327:916-920.9. The American Nimodipine Study Group. Clinical Trial of Nimodipine in Acute Ischemic Stroke. Stroke 1992; 23:3-8.(RL Hughes, Primary Investigator, Ochsner Clinic).10. McCrory DC, Goldstein LB, Sands GP, Oddone ET, Landsman PB, Moore WS, Matchar DB. Predicting complications of carotid endarterectomy. Stroke 1993; 24:1285-1291. (RL Hughes, Alton Ochsner Medical Foundation).11. Goldstein LB, McCrory DC, Landsman PB, Samsa GP, Ancukiewicz M, Oddone EZ, Matchar DB: Multicenter review of preoperative risk factors for carotid endarterectomy in patients with ipsilateral symptoms. Stroke 1994; 25:1116-1121. (RL Hughes, Alton Ochsner Medical Foundation).12. Brott T, Tomick T, Feinberg W, Johnson C, Biller J, Broderick J, Kelly M, Frey J, Schwartz S, Blum C, Nelson JJ,Chambless L, Toole J, for the Asymptomatic Carotid Atherosclerosis Study Investigators: Baseline Silent Cerebral Infarction in the Asymptomatic Carotid Atherosclerosis. Stroke 1994; 25:1116-1121. (RL Hughes, Primary Investigator, Oschner Clinic, New Orleans, La).13. The Asymptomatic Carotid Atherosclerosis (ACAS) Study Group. Endarterectomy for Asymptomatic CarotidArtery Stenosis. JAMA 273:1421-1428 1995; (RL Hughes, Primary Investigator, Oschner Clinic, New Orleans, La).14. Howard G, Baker WH, Chambless LE, Howard V, Jones AM, Toole JF, for the Asymptomatic Carotid Atherosclerosis Study Investigators: An Approach for the Use of Doppler Ultrasound as a Screening Tool for Hemodynamically Significant Stenosis (Despite Heterogeneity of Doppler Performance). Stroke 1996; 27:1951-1957. (RL Hughes, Primary Investigator, Oschner Clinic, New Orleans, La).

15. Young B, Moore WS, Robertson JT, Toole JF, Ernst CB, Cohen SN, Broderick JP, Dempsey RJ, Hosking JD; for theACAS Investigators: An Analysis of Perioperative Surgical Mortality and Morbidity in the Asymptomatic Carotid Atherosclerosis Study. Stroke 1996; 27:2216-2224. (RL Hughes, Primary Investigator, Oschner Clinic, New Orleans, La).16. Ringel SR, Hughes RL. Evidence-based medicine, critical pathways, practice guidelines, and managed care, reflections on the prevention and care of stroke. Arch Neurol. 1996; 53:867-871.17. Karanjia PN, Nelson JJ, Lefkowitz DS, Dick AR, Toole JF, Chamblers LE, Hayes R, Howard VJ. Validation of theACAS TA/Stroke Algorithm. Neurology, 1997; 48:346-351 (RL Hughes, University of Colorado).18. Moore WS, Kempczinski RF, Nelson JJ, Toole JF, for the ACAS Investigators: Recurrent Carotid Stenosis Results of the Asymptomatic Carotid Atherosclerosis Study: Stroke 1998; 29:2018-2025. (RL Hughes, Primary Investigator, Ochsner Clinic, New Orleans, La).19. Alberts MJ, Chaturvedi S, Graham G, Hughes RL, Jamieson DG, Krakowski F, Raps E, Scott P, for the NationalAcute Stroke Team Group. Acute Stroke Teams: Results of a national survey. Stroke 1998; 29:2318-20.20. International Study of Unruptured Intercranial Aneurysms (ISUIA) Investigators. Unruptured intracranial aneurysms.Risk of rupture and surgery. NEJM 1998; 339:1725-33. (RL Hughes, Primary Investigator, Denver).21. Munschauer FE, Hens MM, Priore RL, Stolarski E, Buffamonte S, Carlin A, Wechsler L, Massaro L, Barch C, Hughes R, Anderson A, Sung G, Baker S, Limon S. Screening for atrial fibrillation in the community: A multicenter validation trial. J Stroke and Cerebrovascular Dis 1999; 8:99-103.22. CAPRIE steering Committee. A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemicevents (CAPRIE). Lancet 1996; 348:1329-1338. (RL Hughes, Primary Investigation, Denver)23. Karanjia PN, Nelson JJ, Lefkowitz DS, Dick AR, Toole JF, Chamblers LE, Hayes R, Howard VJ. Validation of theACAS TA/Stroke Algorithm. Neurology, 1997; 48:346-351 (RL Hughes, Denver).24. Kramer A M, Kowalsky L, Cahill J, Lin M, Grigsby J, Hughes R, and Steiner J F, Outcome and utilization differences for older persons with stroke in HMO and fee-for-service systems J Am Geriatr Soc 2000 48:726-734.25. Clark WM, Albers GW, Madden KP, Hamilton S, The rtPA 0-to 6-hour acute stroke trial, part A (A0276g) results of adouble-blind, placebo-controlled, multicenter study. Stroke 2000; 31:811-816.) (Hughes, RL, Primary Investigator, Denver).26. J. David Spence, Virginia J. Howard, Lloyd E. Chambless, M. Rene Malinow, L. Creed Pettigrew, Meir Stampfer,James F. Toole for the VISP Investigators, Vitamin Intervention for Stroke Prevention (VISP) Trial: Rationale andDesign. Neuroepidemiology 2001; 20:16-25.27. Mark M. Belz, MD, Richard L. Hughes, MD, William D. Kaehny, MD, Ann M. Johnson, MS, Godela M. Fick- Brosnahan, MD, Michael P. Earnest, MD, and Patricia A. Gabow, MD, Familial Custering of Ruptured Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease. American Journal of Kidney Diseases, 2001 38:770-776.28. Multidisciplinary Consensus Recommendations from the Advisory Working Group on Stroke Center IdentificationOptions of the American Stroke Association. Recommendations for Improving the Quality of Care through StrokeCenters and Systems: An Examination of Stroke Center Identification Options. Stroke, 2002; 33:e1-e7. (Richard L. Hughes, MD).

29. Mark M. Belz, MD, Godela M. Fick-Brosnahan, MD, Richard L. Hughes, MD, David Rubinstein, MD, Arlene B.Chapman, MD, Ann M. Johnson, MD, Kim K. McFann, M.Div., William D. Kaehny, MD, Patricia A. Gabow, MD. Recurrence of Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease. Kidney International 200363:1824-30. 30. D.A. Hall, MD, C.A. Anderson, MD, C.M. Filley, MD, J Newcombe, MA, C.C.C.S.L.P, R.L. Hughes, MD. A FrenchAccent after an Infarct in the Corpus Callosum. Neurology 2003 60:1551-2.31. Halm EA, Chassin MR, Tuhrim S, Hollier LH, Popp AJ, Ascher E, Dardik H, Faust G, Riles TS. Revisiting theAppropriatnesss of Carotid Endarterectomy. Stroke 2003 34:1464-1472. (RL Hughes MD).32. Englander J, Bushnik T, Duong TT, Cifu D, Zafonte R, Wright J, Hughes R, Bergman W. Analyzing risk factors for late posttraumatic seizures: a prospective multicenter study. Arch Phys Med Rehabil 2003 84:365-73.33. Amarenco P, Bobousslavsky J, Callahan AS, Goldstein L,Hennerici M, Sillsen H, Welch MA, Zivin J, SRARCL Investigators. Design and baseline characteristics of stroke prevention by aggressive reduction in cholesterol levels (SPARCL). Cerebrovasc Dis 2003 16:389-95.34. Weibers D, and the International Study of Unruptured Intracranial Aneurysm Investigators. Unruptured intracranial aneurysms:natural history, clinical outcome, and risk of surgical and endovascular treatment. Lancet 2003 362:103-110.35. J.F. Toole, M.R. Malinow, L.E. Chambless, J.D. Spence, L.C. Spence, L.C. Pettigrew, V.J. Howard, E.G. Sides, C.H.Wang, M. Stampfer. Lowering homocysteine in patients with ischemic stroke to prevent recurrent storke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004291:565-75. (RL Hughes, Denver).36. Shrier, R.W. Belz, M.M. Johnson, A.M. Kaehny, W.D. Hughes, R.L. Rubinstein, D. Gabow, P.A. Repeat Imaging for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease with Initially Negative Studies: A Prospective Ten-Year Follow-up. J Am Soc Nephrol 2004, Volume 15, 1023-8.37. The Stroke Prevention by Aggressive Reduction in Cholesterol (SPARCL) Investigators. High-Dosa Atorvastatin afterStroke or Transient Ischemic Attack. NEJM 2006 355:549-559.38. 52. Warfarin versus aspirin in patients with reduced cardiac ejection fraction (WARCEF): rationale, objectives, and design. Pullicino P, Thompson JL, Barton B, Levin B, Graham S, Freudenberger RS; WARCEF Investigators. J Card Fail. 2006 Feb; 12(1):39-46.39. Effects of Intense Low-Density Lipoprotein Cholesterol Reduction in Patients with Stroke or Transient IschemicAttack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) TrialPierre Amarenco, Larry B. Goldstein, Michael Szarek, Henrik Sillesen, Amy E. Rudolph, Alfred Callahan, III, MichaelHennerici, Lisa Simunovic, Justin A. Zivin, K. Michael A. Welch on behalf of the SPARCL InvestigatorsStroke. 2007; 38:3198-320440. Kluger BM, Hughes RL, Anderson CA, Hassell KL. Non-traumatic carotid dissection and stroke associated with anti- phospholipid antibody syndrome: Report of a case and review of the literature. Neurol India 2008; 56:77-841. Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke Ralph L. Sacco, M.D., Hans Christoph Diener, M.D., Ph.D.,Salim Yusuf, M.B., B.S., D.Phil., Daniel Cotton, M.S., Stephanie Ôunpuu, Ph.D.,William A.Lawton, B.A., Yuko Palesch, Ph.D., Reneé H. Martin,

Ph.D.,Gregory W. Albers, M.D., Philip Bath, F.R.C.P., Natan Bornstein, M.D.,Bernard P.L. Chan, M.D., Sien-Tsong Chen, M.D., Luis Cunha, M.D., Ph.D.,Björn Dahlöf, M.D., Ph.D., Jacques De Keyser, M.D., Ph.D.,Geoffrey A. Donnan, M.D., Conrado Estol, M.D., Ph.D., Philip Gorelick, M.D., Vivian Gu, M.D., Karin Hermansson, D.M.Sc., Lutz Hilbrich, M.D., Markku Kaste, M.D., Ph.D., Chuanzhen Lu, M.D., Thomas Machnig, M.D., Prem Pais, M.D., Robin Roberts, M.Tech., Veronika Skvortsova, M.D., Philip Teal, M.D., Danilo Toni, M.D., Cam VanderMaelen, Ph.D., Thor Voigt, M.D., Michael Weber, M.D., and Byung-Woo Yoon, M.D., Ph.D., for the PRoFESS Study Group* N Engl J Med 2008 359:1238-1251.42. Telmisartan to Prevent Recurrent Stroke and Cardiovascular EventsSalim Yusuf, M.B., B.S., D.Phil., Hans-Christoph Diener, M.D., Ph.D., Ralph L. Sacco, M.D., Daniel Cotton, M.S., Stephanie Ôunpuu, Ph.D., William A. Lawton, B.A., Yuko Palesch, Ph.D., Reneé H. Martin, Ph.D., Gregory W. Albers, M.D., Philip Bath, F.R.C.P., Natan Bornstein, M.D., Bernard P.L. Chan, M.D., Sien-Tsong Chen, M.D., Luis Cunha, M.D., Ph.D., Björn Dahlöf, M.D., Ph.D., Jacques De Keyser, M.D., Ph.D., Geoffrey A. Donnan, M.D., Conrado Estol, M.D., Ph.D., Philip Gorelick, M.D., Vivian Gu, M.D., Karin Hermansson, D.M.Sc., Lutz Hilbrich, M.D., Markku Kaste, M.D., Ph.D., Chuanzhen Lu, M.D., Thomas Machnig, M.D., Prem Pais, M.D., Robin Roberts, M.Tech., Veronika Skvortsova, M.D., Philip Teal, M.D., Danilo Toni, M.D., Cam VanderMaelen, Ph.D., Thor Voigt, M.D., Michael Weber, M.D., Byung-Woo Yoon, M.D., Ph.D., for the PRoFESS Study Group. N Eng J Med 2008, 359:1225-123743. Relative Effects of Statin Therapy on Stroke and Cardiovascular Events in Men and WomenSecondary Analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) StudyLarry B. Goldstein, MD; Pierre Amarenco, MD; Marian LaMonte, MD; Steven Gilbert, PhD; Michael Messig, PhD;Alfred Callahan, MD; Michael Hennerici, MD, PhD; Henrik Sillesen, MD, MSc; K. Michael A. Welch, MB, ChB on behalf of the SPARCL Investigators. Stroke 2008: 39:2444-2448.44. Atorvastatin Reduces the Risk of Cardiovascular Events in Patients with Carotid Atherosclerosis: A SecondaryAnalysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial Henrik Sillesen, Pierre Amarenco, Michael G. Hennerici, Alfred Callahan, Larry B. Goldstein, Justin Zivin, MichaelMessig, K. Michael Welch on Behalf of the SPARCL Investigators Stroke. 2008; 39:3297-330245. Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels studyL. B. Goldstein, MD, P. Amarenco, MD, M. Szarek, MS, A. Callahan, III, MD, M. Hennerici, MD, PhD, H. Sillesen, MD, DMSc, J. A. Zivin, MD, PhD, K.M.A. Welch, MD, PhD On behalf of the SPARCL Investigators. Neurology 2008;70:2364-2370.46. Effect of atorvastatin in elderly patients with a recent stroke or transient ischemic attack. Chaturvedi S, Zivin J, Beazna Amarenco P, Callahan A, Goldstein LB, Hennerici M, Sillesen H, Rudolph A, Welch MA for the SPARCL Investigators. Neurology 2009; 72:688-694.47. Results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial by Stroke Subtypes Pierre Amarenco, Oscar Benavente, Larry B. Goldstein, Alfred Callahan, III, Henrik Sillesen, Michael G. Hennerici, Steve Gilbert, Amy E. Rudolph, Lisa Simunovic, Justin A. Zivin, K. Michael A. Welch on behalf of the SPARCL Investigators Stroke. 2009; 40:1405-1409;48. Statin Treatment and Stroke Outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial. Larry B. Goldstein, Pierre Amarenco, Justin Zivin, Michael Messig, Irfan Altafullah, Alfred Callahan, Michael Hennerici, Mary J. MacLeod, Henrik Sillesen, Richard Zweifler, K. Michael, A. Welch on behalf of the SPARCL Investigators. Stroke. 2009; 40:3526-353149. Effect of Telmisartan on Functional Outcome, Recurrence, and Blood Pressure in Patients With Acute Mild Ischemic Stroke: A PRoFESS Subgroup Analysis. Philip M. W. Bath, Reneé H. Martin, Yuko Palesch, Daniel Cotton, Salim Yusuf, Ralph Sacco, Hans-Christoph Diener, Danilo Toni, Conrado Estol, Robin Roberts for the PRoFESS Study Group. Stroke. 2009; 40:3541-3546

50. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR, Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W; ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group, Allen K, Mau J, Meier D, del Zoppo G, De Silva DA, Butcher KS, Parsons MW, Barber PA, Levi C, Bladin C, Byrnes G. for the ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group Investigators.The Lancet 375:1695 - 1703, 15 May 2010 Collaborators (752)51. Effect of combined aspirin and extended-release dipyridamole versus clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PRoFESS subgroup analysis. Bath PM, Cotton D, Martin RH, Palesch Y, Yusuf S, Sacco R, Diener HC, Estol C, Roberts R; PRoFESS Study Group. Stroke. 2010 Apr; 41(4):732-8. Epub 2010Feb 24.PMID: 20181679 [PubMed - indexed for MEDLINE]52. Level of systolic blood pressure within the normal range and risk of recurrent stroke.Ovbiagele B, Diener HC, Yusuf S, Martin RH, Cotton D, Vinisko R, Donnan GA, Bath PM; PROFESS Investigators.JAMA. 2011 Nov 16; 306(19):2137-44.53. Risk of recurrent stroke in patients with silent brain infarction in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) imaging substudy. Weber R, Weimar C, Wanke I, Möller-Hartmann C, Gizewski ER, Blatchford J, Hermansson K, Demchuk AM, Forsting M, Sacco RL, Saver JL, Warach S, Diener HC, Diehl A; PRoFESS Imaging Substudy Group. Stroke. 2012 Feb; 43(2):350-5. Epub 2012 Jan 19.54. Reversible Cerebral Vasoconstriction Syndrome 3 Months after Blood Transfusion. Braun CN, Hughes RL, Bosque PJ.J Stroke Cerebrovasc Dis. 2012 Feb 15. [Epub ahead of print]55. Vorapaxar in the Secondary Prevention of Atherothrombotic EventsDavid A. Morrow, M.D., M.P.H., Eugene Braunwald, M.D., Marc P. Bonaca, M.D., Sebastian F. Ameriso, M.D., Anthony J. Dalby, M.B., Ch.B., Mary Polly Fish, B.A., Keith A.A. Fox, M.B., Ch.B., Leslie J. Lipka, M.D., Ph.D., Xuan Liu, Ph.D., José Carlos Nicolau, M.D., Ph.D., A.J. Oude Ophuis, M.D., Ph.D., Ernesto Paolasso, M.D., Benjamin M. Scirica, M.D., M.P.H., Jindrich Spinar, M.D., Ph.D., Pierre Theroux, C.M., M.D., Stephen D. Wiviott, M.D., John Strony, M.D., and Sabina A. Murphy, M.P.H. for the TRA 2P–TIMI 50 Steering Committee and Investigators. N Engl J Med2012; 366:1404-1413April 12, 201256. Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm Shunichi Homma, M.D., John L.P. Thompson, Ph.D., Patrick M. Pullicino, M.D., Bruce Levin, Ph.D., Ronald S. Freudenberger, M.D., John R. Teerlink, M.D., Susan E. Ammon, N.P., Susan Graham, M.D., Ralph L. Sacco, M.D., Douglas L. Mann, M.D., J.P. Mohr, M.D., Barry M. Massie, M.D., Arthur J. Labovitz, M.D., Stefan D. Anker, M.D., Ph.D., Dirk J. Lok, M.D., Piotr Ponikowski, M.D., Ph.D., Conrado J. Estol, M.D., Ph.D., Gregory Y.H. Lip, M.D., Marco R. Di Tullio, M.D., Alexandra R. Sanford, M.S., Vilma Mejia, B.S., Andre P. Gabriel, M.D., Mirna L. del Valle, B.S., and Richard Buchsbaum for the WARCEF Investigators. N Engl J Med 2012; 366:1859-1869May 17, 201257. Efficacy and Safety of Vorapaxar in Patients with Prior Ischemic Stroke David A. Morrow, Mark J. Alberts, Jay P.Mohr, Sebastian F. Ameriso, Marc P. Bonaca, Shinya Goto, Graeme J. Hankey, Sabina A. Murphy, Benjamin M.Scirica, and Eugene Braunwald , for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering Committee and Investigators. Stroke. 2013; 44:691-698, published online before print February 8 2013, doi:10.1161/STROKEAHA.111.00043358. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance Intervention after Stroke (IRIS).Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Lovejoy AM, Parsons MW, Peduzzi PN, Ringleb P, Schwartz GG, Spence JD, Tanne D, Young LH, Kernan WN on behalf of the IRIS Trial Investigators. Am Heart J 2014:168:823-829.

59. Case D, Seinfeld J, Folzenlogen Z,Simpson J, Hughes R. Acute posterior Multifocal Placoid Pigment Epitheliopathy associated with Stroke: A Case Report and review. Journal of Stroke and Cerebrovascular Diseases 2015 24:e295-302.60. Borah S, McConnell B, Hughes R, Antoniello D, and Kluger B. Potential Relationship of Self-Injurous Behavior to Right Temporo-Parietal Lesions. Under Review.61. Keenan, WN et al. Insulin Resistance Intervention in Stroke Trial. N Engl J Med 2016. DOI:10:1056/NEJMoa156930

BOOK CHAPTERS:1. Hughes RL: CBF determination within the first eight hours of cerebral infarction. In Yonas HW, ed. Cerebral BloodFlow Measurement with Stable Xenon-enhanced Computed Tomography. New York:Raven Press, 1992:121-125.2. Hughes RL: Neurology. In Frolich E, ed. Rypian Medical Board Review. Clinical Sciences. 16th edition. J.P.Lippencott, Philadelphia, 19923. Hughes RL, Earnest MP: Transient Ischemic Attack and Cerebrovascular Accident. In Markovchick VJ, Pons PT, and Wolfe RE, eds. Emergency Medicine Secrets. Hanley and Belfur Inc., Philadelphia, 1993.4. Hughes RL: Cerebrovascular Disease. In Jahnigen D, Schrier R eds, Geriatrics, Blackwell, 1996.5. Anderson, CA, Hughes, RL: Tremor, Common Disorders of the Nervous System: Primary Care Secrets; Mosby1994, pp 311-313.6. Foley, PA, Hughes, RL: Muscle Weakness, Common Disorders of the Nervous System: Primary Care Secrets; Mosby 1994, pp 313-316.7. Redosh, D, Hughes, RL: Numbness and Tingling, Common Disorders of the Nervous System: Primary CareSecrets: Mosby 1994, pp 316-318.8. Villalobos. R, Hughes, RL: Cerebrovascular Disorders, Common Disorders of the Nervous System: Primary CareSecrets: Mosby 1994, pp 319-320.9. Hughes, RL, Ravilochan, K: Dizziness and Syncope, Common Disorders of the Nervous System: Primary CareSecrets: Mosby 1994, pp 323-326.10. Kumpe D, Hughes RL. Thrombolytic Therapy for Acute Stroke. In Whittemore AD ed, Advances in VascularSurgery. Mosby 1996.11. Anderson CA, Hughes RL: Tremor. In Mladenovic J ed: Primary Care Secrets, second edition. Hanley and Belfus, Philedelphia, 1998 Chapter 77.12. Ferguson MA, Hughes RL: Muscle Weakness. In Mladenovic J ed: Primary Care Secrets, 2nd . Hanley and Belfus, Philedelphia, 1998 Chapter 78.13. Ferguson MA, Hughes RL: Numbness and Tingling. In Mladenovic J ed: Primary Care Secrets, 2nd edition. Hanley and Belfus, Philedelphia, 1998 Chapter 79.14. Anderson CA, Hughes RL: Cerebrovascular Disorders. In Mladenovic J ed: Primary Care Secrets, 2nd edition.Hanley and Belfus, Philedelphia, 1998 Chapter 80.15. Distad DJ, Hughes RL: Dizziness and Syncope. In Mladenovic J ed: Primary Care Secrets, 2nd edition. Hanley andBelfus, Philedelphia, 1998 Chapter 82.

16. Shrestha A, Hughes RL: Seizure Disorders. In Mladenovic J ed: Primary Care Secrets, 2nd edition. Hanley andBelfus, Philedelphia, 1998 Chapter 83.17. Liang B, Hughes R. Clinical Science. Hospital Practice Board Review Manual 1998; 1:35-42.18. Anderson CA, Hughes RL: Cerebrovascular Disease. In Markovchick V ed. Emergency Medicine Secrets. Hanley and Belfus, Philadelphia. 1998. Chapter 21.19. Hughes RL, Anderson CA, Sung GA: Diagnostic Evaluation and Medical Management of Patients with IschemicCerebrovascular Disease. In Rutherford RB, ed. Vascular Surgery, fifth edition. Sanders, Philadelphia, 1999 Chapter128.20. Hughes RL, Earnest MP, Transient Ischemic Attacks and Cerebrovascular Accident. In Markovchick VJ, Pons PT.Emergency Medicine Secrets. 2002.21. FMD, Wilson J, Hughes RL, :Fibromuscular dysplasia. eMedicine Journal, October 10, 2003.22. Hughes RL, C. Alan Anderson, Tremor. Common Disorders of the Nervous System. Primary Care Secret 3rdEdition, Jeanette Mladnovic, MD 2004.23. Hughes RL, Michele A. Ferguson, Muscle Weakness. Common Disorders of the Nervous System Primary CareSecrets 3rd Edition. Jeanette Mladenovic, MD 2004.24. Hughes RL, Michele A. Ferguson, Numbness and Tingling. Common Disorders of the Nervous System. PrimaryCare Secrets 3rd Edition. Jeanette Mladenovic, MD, 2004.25. Hughes RL, C. Alan Anderson, Cerebrovascular Disorders. Common Disorders of the Nervous System. PrimaryCare Secrets 3rd Edition. Jeanette Mladenovic, MD, 2004.26. Hughes RL, Jane Distad, Dizziness and Syncope. Common Disorders of the Nervous System. Primary Care Secrets3rd Edition. Jeanette Mladenovic, MD, 2004.27. Hughes RL, Achana Ahrestha, Seizure Disorders. Common Disorders of the Nervous System. Primary Care Secrets3rd Edition. Jeanette Mladneovic, MD 2004.28. Maa EA, Hughes RL. Seizures in the ICU. In: Albet RK, Ranieri M, Slutsky A, Takkala T, Torres T. Clinical CriticalCare Medicine. Mosby, Philadelphia. 2006 415-430.29. Hughes RL, Earnest MP, Transient Ischemic Attacks and Cerebrovascular Accident. In Markovchick VJ, Pons PT.Emergency Medicine Secrets. 2006.30. FMD, Wilson J, Hughes RL, :Fibromuscular dysplasia. eMedicine Journal. Updated 2010.

LETTERS, ABSTRACTS, AND OTHER PUBLICATIONS:1. “The Magic Ninth,” A short story in The Alpha Centuri Communicator, 1977.2. Hughes RL: Letter to the Editor. NEJM 315:522, 1986.3. Hughes RL, Yonas H, Gur D, Latchaw R: Stable Xenon Enhanced CT in the First Eight Hours of Cerebral Infarction.Stroke 1987; 18:283. (Abstract)4. Hughes RL, Kaehny W, Earnest MP, Gabow PA: Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney

Disease Show Familiar Clustering. Neurol 1988; 38 (Supp 1):131-2. (Abstract)5. Hughes RL, Bluth EI: Relationship between carotid plaque hematoma and ischemic cerebrovascular symptoms.Stroke 1988; 19:534. (Letter)6. Yonas H, Hughes, RL, Hirsch WL, Latchaw RE, Gur D: Stable xenon-enhanced CT within the first 8 hours of cerebral infarction. Rad 1987; 165(P) Suppl: 40. (Abstract)7. Bluth EI, Hughes RL: Importance of carotid artery plaque distribution and hemorrhage. Arch Neurol 1988; 45:602. (Letter)8. Hughes RL, Ochsner JL: Preventing and Treating Stroke. Executive Health, fall 1989.9. Hughes RL: Cyclosporine related central nervous system toxicity in cardiac transplantation. NEJM 1990; 323:420-421.10. Hughes RL: Successful treatment of chronic misery perfusion with acetazolamide: report of six cases. Neurology1991; 41 (Suppl. 1):402. (Abstract)11. Hughes, RL: NEJM 325:664, 1991. (Letter)12. Hughes RL: Technetium 99 HMPAO Spect During an episode of Transient Global Amnesia - A case report. Stroke1992; 23:463. (Abstract)13. Ahmed L, Kramer A, Eckhoff D, Hughes RL, Eilertson T, Wallace H: Placement factors for elderly stroke and hip fracture patients in acute rehabilitation or skilled nursing facility. J Am Geriatr Soc. (Abstract).14. Hughes, RL, Chapman A, Rubinstein D, et al: Recurrent Intracranial Aneurysms (ICA) in Autosomal DominantPolycystic Kidney Disease (ADPKD). Stroke 1996; 27:178. (Abstract).15. Hughes RL, Corbey J, Liang B, Tyler B, and Ringel S. Residency restructuring for future resident education: making difficult choices at the University of Colorado. Neurology 1997 48:A71.16. Hughes RL, Anderson CA, Kumpe D, Coldwell D. Selection of patients for intra-arterial CNS procedures in the era of intravenous TPA. J of Stroke and Cerebrovascular Disease 1997, 6:472.17. Hughes RL, Smith D, Smith R, Lowther M. Creation of a regional organization to support stroke resuscitation: TheColorado Acute Stroke Network (CASN). J of Stroke and Cerebrovascular Disease 1997, 6:471.18. Hughes RL, Grigsby J, Ahmed LA, Eilertson TB, Kramer AM. ADL outcome of cortical stroke at one year based on acute images. Stroke 1998; 29:317.19. Anderson A, Smith DB, Hughes RL. The Colorado Acute Stroke Network experience with intravenous r-TPA in acute ischemic stroke. Neurology 1998; 50:A157.20. Torner JC, Wiebers DO, Brown RD, Whisnant JP: Factors Related to Location of Unruptured Cerebral Aneurysms: Report of the International Study of Unruptured Intracranial Aneurysms (ISUIA) Investigators. Stroke 1999; 30:270. (Hughes RL, Denver, Co.)21. Clark WM, Albers GW, for the Atlantis Stroke Study Investigators. The Atlantis rt-PA (Alterplase) Acute StrokeTrial: Final Results. Stroke 1999; 30: 234. (Hughes RL, Denver, Co.)22. Baker WH, Howard VJ, Howard G, Toole JF, for the ACAS Investigators. The Effect of Contralateral Occlusion onPeri-operative and Late Stroke Rates in the Asymptomatic Carotid Atherosclerosis Study (ACAS). Stroke 1999; 30:242. (Hughes RL, Denver, Co.)23. Malinow MR, Chambless LE, Howard VJ, Toole JF, for the VISP Investigators. Screening of Plasma Homocyst(e)ineLevels in Stroke Patients for the Vitamin Intervention for Stroke Prevention (VISP) Clinical Trial. Stroke 1999; 30:

258. (Hughes RL, Denver, Co.)24. ISUIA Investigators, Mayo Clinic, Rochester, MN, Determinants of Intervention for Unruptured Aneurysms Less than10 MM in Diameter Stroke 2000; 31:28925. Grotta JC, Combination Therapy Stroke Trial: rt-PA +/-Lubeluzole Univ of Texas Medical School, Houston, TX.Stroke 2000; 31:278 (Hughes RL, Denver, Co)26. Sweeney C, Pelak V, Bennett J, Hughes RL. Delayed onset of optic nerve injury following cisplatin. J of Neuro-Ophth200027. Hughes RL, Frey LC. Magnesium Induced Hemorrhage after Successful Resuscitation of Stroke with IV rTPA. WorldStroke Congress. Melbourne, Australia. November 2000.29. Mueller DA, Anderson CA, Hughes RL, Newcombe J, Foreign Accent Syndrome following a stroke in the corpus callosum. ANPA, San Diego. J Neuropsychiatry Clin Neurosci 14:1, 2002.32. Torner JC, Weiber DO, Piepgras D, Brown RD, and the ISUIA Investigators. Perioperative Cerebral Infarction and hemorrhage in Surgical treatment of Unruptured Intracranial Aneurysms. Stroke 2003 34:246.

41. Smith, DB, Hughes RL, Inter-hospital Transfers in the Colorado Stroke System. ISC Feb 2012.42. Hughes,R, Nagal M. Herpes Simplex Virus Infection in the Acute Presentation of Fibromuscular Dysplasia.WSOC, Hyderabad, India. October 2016.