UNIVERSITY OF COLORADO SCHOOL OF MEDICINE · · 2018-02-072005-2011 ASA/JCAHO Comprehensive...
Transcript of UNIVERSITY OF COLORADO SCHOOL OF MEDICINE · · 2018-02-072005-2011 ASA/JCAHO Comprehensive...
Richard L. Hughes, MD - Page 1 of 21
CURRICULUM VITAE
RICHARD L. HUGHES, M.D.
Professor of Neurology
12401 East Seventeenth Avenue, Mail Stop L950
Aurora, CO 80045
720.848.8522
720.848.0194 (Fax)
303.399.1261 (Home)
303.880.0908 (Cell)
BIOGRAPHY:
Birth Date: June 5, 1955
Birthplace: Rumford, Maine
EDUCATION AND EXPERIENCE:
1972-1973 New Mexico Highlands University, Las Vegas, New Mexico
1973-1976 B.A. Chemistry University of New Mexico, Albuquerque, New Mexico
1978-1982 M.D. University of New Mexico School of Medicine, Albuquerque, New Mexico
1982-1983 Intern, Medicine and Psychiatry, University of New Mexico, Albuquerque, New Mexico
1983-1986 Resident in Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania
1986-1987 Clinical Fellow in Cerebrovascular Disease, University of Colorado, Denver, Colorado
ACADEMIC APPOINTMENTS:
1987-1991 Ochsner Clinic, Tulane University Medical School Rehabilitation Unit
New Orleans, Louisiana, Staff Neurologist-General Partner Department of Neurology,
Clinical Assistant Professor of Neurology
1991-2016 Denver Health Medical Center, University of Colorado School of Medicine
Denver, Colorado, Division of Neurology (Chief 1995), Professor of Neurology (2008)
2016-present University of Colorado, Anschutz Medical Campus, Professor of Neurology
HONORS, SPECIAL RECOGNITIONS AND AWARDS:
1995 Outstanding Teacher of the Year, University of Colorado, Department of Neurology
Resident Class of 1995
1997-1998 Excellence in Teaching Award, University of Colorado, Department of Neurology
1998-1999 Excellence in Teaching Award, University of Colorado, Department of Neurology
Richard L. Hughes, MD - Page 2 of 21
1999-2000 Excellence in Teaching Award, University of Colorado, Department of Psychiatry
2000 American Heart Association, Robert Ginsberg Medical Volunteer of the Year
2001 7th Annual Outstanding Clinician Award, Denver Health Medical Center
2003 Outstanding Teacher of the Year, University of Colorado, Medical School Class of 2003
2003 “Mr. Smooth Award,” University of Colorado, 2003 Residency Class
2003 American Heart Association, Advocate of the year – Colorado
2003-2006 Best Doctors in America®
2007 Nominee, University of Colorado Teaching Excellence
2008 Nominee, University of Colorado Teaching Excellence
2009-2016 Best Doctors in America®
2017 Resident Teaching Award, University of Colorado
PROFESSIONAL ORGANIZATIONS:
American Academy of Neurology Fellow
American Heart Association
American Medical Association Fellow
Colorado Acute Stroke Network (Co-Founder)
Colorado Society of Clinical Neurologists
North American Neuro-Ophthalmology Society
Stroke Council
MAJOR COMMITTEE AND SERVICE RESPONSIBILITIES:
1993-1995 President, Colorado Society of Clinical Neurologists
1995-1996 Secretary - Treasurer, Denver General Hospital
1996-2002 Rocky Mountain Stroke Association (Board)
1997-present American Heart Association, Denver Board
1998-2002 Chairman, AHA Desert Mountain Affiliate Stroke Advisory Committee
1999-2002 Co-Chair, Denver Operation Stroke, American Stoke Association
Richard L. Hughes, MD - Page 3 of 21
2000-2003 University of Colorado School of Medicine Faculty Senate
2000-2003 American Heart Association Desert-Mountain Affiliate Board
2001-2004 American Stroke Association Advisory Board
2002-present Colorado Department of Public Health and Environment Stroke Advisory Committee
2002-2006 American Heart Association Pacific Mountain Affiliate Stroke Committee
2002-2011 ASA/JCAHO Primary Stroke Center Certification Committee
2005-2011 ASA/JCAHO Comprehensive Stroke Center Certification Committee
2006-2008 AHA PMA Strategic Planning Committee
2009-2012 University of Colorado School of Medicine Promotions Committee, Co-Chair 2012
2012-2015 AHA Hospital Certification Science Committee
LICENSURE AND BOARD CERTIFICATIONS:
Pennsylvania (Inactive) MD-030075-E
Bureau of Professional and Occupational Affairs
P.O. Box 2649, Harrisburg, PA 17105-2649
Louisiana (Inactive) 07604R
Louisiana State Board of Medical Examiners
P.O. Box 30250, New Orleans, LA 70190-0250
Colorado (Active) 0027568
Colorado Medical Board
1560 Broadway, Denver, CO 80202-5140
Wyoming (Active) 11208A
Wyoming Board of Medicine
130 Hobbs Avenue, Suite A\Cheyenne, WY 82002
LOBBYING:
Washington DC: 1995, 2000, 2002 with the American Academy of Neurology, the American Heart
Association and the Colorado Society of Clinical Neurologists
COLORADO STROKE BILL:
Jack Pommer, then aide to Boulder House Representative Todd Saliman, and the AHA Desert Mountain
Affiliate Stroke Committee (Chair, Richard L. Hughes, MD.) wrote this legislation. The bill passed in March
2002 by both the Colorado House and Senate after testimony by Richard L. Hughes, MD among others.
Governor Bill Owens signed the bill into law in May 2002. This legislation has set up a statewide advisory
board on stroke policy through the Colorado Department of Public Health and Environment, now the
Colorado Stroke Alliance. There is now a Stroke Registry in Colorado, including the University of Colorado
Hospital and Denver Health Medical Center.
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PRIMARY STROKE CENTER CERTIFICATIONS:
The JCAHO Disease specific certification process has collaborated with the ASA, via the ASA Advisory
Committee (Richard L. Hughes, MD, member) and the ASA Primary Stroke Center Certification Sub-
Committee (Richard L. Hughes, MD, member).
COMPREHENSIVE STROKE CENTER CERTIFICATION:
In the summer of 2005, the Comprehensive Stroke Center (CSC) guidelines were published and the ASA
committee for CSC was formed (Richard L. Hughes, MD, member). Drs. Richard L. Hughes and Anthony
Furlan have presented their analysis of what key factors constitute a CSC and distinguish the CSC from a
PSC. These recommendations will be carried forward with other specialty organizations.
BOARD EXAMINER:
National Board of Medical Examiners, Parts I, II, III Neurology Board Certified 1988
Neurology Board Examiner (1990, 95, 99, 00, 00, 01, 01, 03)
Diplomat, Vascular Neurology 2005, & 2015
REVIEWER:
Circulation
International Journal of Stroke
Journal of Neuro-Ophthalmology
Journal of Stroke and Cerebrovascular Disease
National Stroke Association
Stroke
The Neurologist
INTERNATIONAL INVITED SPEAKING:
DATE: LOCATION: TITLE:
December 2016 Nassau, Bahamas Neurology Selected Topics
December 2015 Brussels, Belgium First European Fibromuscular Dysplasia
Conference
January 2015 St. Maarten Neurology for the Primary Care Provider
October 2006 Stroke Society of Australasia,
Adelaide, Australia
Comp Stroke Certification
May 2006 University of Heidelberg, Germany Visiting Professor
September 2002 Stroke Society of Australasia,
Queensland, Australia
Stroke Panelist / North America
December 2001 Train to End Stroke, Jamaica Speaker / Chair
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October 1998 Boehringer-Ingelheim, Crete, Greece Advisory Panel
September 1994 Janssen, Toronto, Canada Stroke Resuscitation
July 1994 HCI, Glasgow, Scotland Visiting Professor
NATIONAL AND REGIONAL INVITED SPEAKING:
DATE: LOCATION: TOPIC: COURSE:
November 2017 Maui, HI Speaker Neurology for the PCP
June 2017 Los Angeles, CA Speaker Neurology for the PCP
April 2017 Las Vegas, NV Speaker Neurology for the PCP
February 2017 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
March 2016 Kona, HI Headache Vertigo;
Neuropathic Pain
Neurology Updates for Internists
Stroke:
February 2016 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
February 2016 Beaver Creek, CO NIH IRIS Trial
February 2015 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
February 2015 Beaver Creek, CO Updates in Stroke 2015
February 2014 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
October 2013 Princeville, HI Neurology for the PCP Series of four talks
February 2013 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
October 2012 Albuquerque, NM Comprehensive Stroke Western States Stroke
Consortium
June 2012 Estes Park, CO Neurology Update Family Medicine Review
February 2012 Beaver Creek, CO Stroke Call-Fleming Syndrome
February 2012 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
July 2011 Estes Park, CO Neurology Update Internal Medicine Review
February 2011 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
September 2010 Denver, CO Stroke Internal Medicine
September 2010 Albuquerque, NM Comprehensive Stroke Western States Stroke
Consortium
February 2010 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
July 2009 Estes Park, CO Stroke Update Internal Medicine Review
June 2009 Estes Park, CO Seizures Family Medicine Review
November 2008 Denver, CO Stroke Update Family Medicine Review
October 2008 Boulder, CO Atherosclerosis AHA Prevention Series
June 2008 Estes Park, CO Stroke Update Family Medicine Review
February 2008 Beaver Creek, CO *Co-Director Neurosurgery in the Rockies
November 2007 Denver, CO Stroke Update Family Medicine Review
June 2007 Estes Park, CO Stroke Update Internal Medicine
March 2007 Denver Health Intracerebral Hemorrhage CME Course
February 2007 Vail, CO Statins in Cerebrovascular
Disease
Neurosurgery in the Rockies
February 2007 Vail, CO *Co-Director Neurosurgery in the Rockies
October 2006 Barrow Neurological
Institute, Phoenix, AZ
Cavernous Hemangiomas Speaker
April 2006 Denver, CO Stroke in Women Go Red for Women
February 2006 Vail, CO *Co-Director Neurosurgery in the Rockies
February 2006 Breckenridge, CO CSC in USA Vista Investigators
February 2006 Denver, CO Stroke in Women CV Summit for Women
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February 2006 Vail, CO Neurological injuries Neurology Retreat
April 2004 Denver, CO AJA/JCAHO Stroke Update
January 2004 Portland, OR ASA/JCAHO Stroke Center
January 2004 Montrose, CO Stroke Update UCHSC Outreach
October 2003 Denver, CO Hypothermia DHMC ICU
September 2003 Denver, CO Stroke UCHSC UCHSC Rehabilitation
April 2003 Denver, CO Stroke UCHSC Cardiology
December 2002 Denver, CO Stroke Neurology Journal Club
December 2002 Denver, CO Stroke UCHSC OB/GYN
September 2002 Los Angeles , CA Stroke Legislation Western States Stroke
Consortium
September 2002 Estes Park, CO Stroke Workshop AHA/ACLS
September 2002 Estes Park, CO ACLS-Stroke AHA
April 2002 Denver, CO Update ASA Seminar
February 2002 San Antonio, TX ASA/ISM Annual ASA Update
June 2001 Denver, CO Stroke Imaging ACVIM
June 2001 Kona, HI Stoke Volunteer TTES
May 2001 Littleton, CO Stroke Update RMSA
November 2000 Boulder, CO Stroke Prevention Panel
October 2000 Estes Park, CO Operation Stroke AHA
September 2000 Aspen, CO Operation Stroke WSSC
September 2000 Denver, CO Stroke Update RMSA
August 2000 Denver, CO Stroke Family Medicine
August 2000 Denver, CO Brain Localization Neuropsychiatry
August 2000 Denver, CO Stroke Update Lutheran
August 2000 Meeker, CO Stroke Resuscitation CASN/AHA
July 2000 Estes Park, CO Stroke Update Internal Medicine
June 2000 Bryn Mawr, PA Stroke Outcome Rehabilitation
May 2000 Phoenix, AZ Stroke Resuscitation AHA
March 2000 Aspen, CO Stroke Resuscitation CASN/AHA
November 1999 Denver, CO Operation Stroke AHA Board
October 1999 DHNC Stroke Resuscitation Medicine Research
September 1999 Snowmass, CO Atrial Fibrillation NSA Seminar
July 1999 Aspen, CO Thrombolytic UC-CME
March 1999 Snowmass, CO *Session Co-Chair NANOS
January 1999 DHMC Migraine Emergency Medicine
October 1998 Denver, CO Stroke Success RMSA
September 1998 Los Angeles, CA CASN RMSA
May 1998 Denver, CO *Anti-Thrombotic
Therapy
Course Director
April 1998 Ft. Lauderdale, FL Stroke Resuscitation NSA Seminar
February 1998 Jackson, WY Stroke St. John’s Hospital
February 1998 Denver, CO Stroke UC-CME
November 1997 Denver, CO Carotid Disease Vascular Grand Rounds
October 1997 Denver, CO Stroke Resuscitation AAN Seminar
October 1997 Boise, ID Stroke Resuscitation NSA Seminar
October 1997 Colorado Springs Headache Military Physicians
August 1997 Albuquerque, NM Stroke Resuscitation Neurology Grand Rounds
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August 1997 Denver, CO Carotid Disease Medicine Grand Rounds
July 1997 Denver, CO Reperfusion Injury Grand Rounds
June 1997 Evanston, WY Thrombolytics CASN/AHA Series
May 1997 Riverton, WY Thrombolytics CASN/AHA Series
May 1997 Lander, WY Thrombolytics CASN/AHA Series
May 1997 Denver, CO CASN CASN Teleconference
March 1997 Denver, CO Stroke Resuscitation St. Joseph’s Grand Rounds
February 1997 Cody, WY Thrombolytics CASN/AHA Series
February 1997 Jackson, WY Thrombolytics CASN/AHA Series
January 1997 Vail, CO Thrombolytics Emergency Medicine
December 1996 Cheyenne, WY Thrombolytics CASN/AHA Series
November 1996 Farmington, NM Thrombolytics in Stroke CASA/AHA Series
October 1996 Casper, WY Thrombolytics in Stroke CASN/AHA Series
October 1996 Denver, CO Stroke Medicine CPC
July 1996 Estes Park, CO Stroke Resuscitation IM Review Course
June 1996 Colorado Springs, CO *Session Co-Chair NSA-North American
March 1996 Denver, CO Stroke Geriatric Course
January 1996 Denver, CO Headache and Epilepsy Seminar
June 1995 Denver, CO *Session Co-Chair NSA Seminar
September 1994 Denver, CO Stroke Colorado Nursing
July 1994 Marshfield, WI FMD Clinical Grand Rounds
April 1994 Palm Springs, CA Stroke NSA Seminar
March 1994 Breckenridge, CO Stroke Geriatric Review Course
January 1994 Denver, CO Stroke Fitzsimmons
July 1993 Estes Park, CO Stroke IM Review Course
April 1993 New Orleans, LA Carotid Disease Ochsner Course
January 1993 Loveland, CO Stroke McKee Medical Center
July 1992 Denver, CO Keynote Address Rehabilitation Seminar
May 1992 Denver, CO Thrombolytic Therapy CSCN
March 1992 Winter Park, CO Stroke Geriatric
November 1990 New Orleans, LA Stroke Geriatric
September 1990 New Orleans, LA Resuscitation Tulane Neurology
April 1990 New Orleans, LA FMD Tulane Neurology
February 1990 New Orleans, LA Atypical TIA Vascular Surgery
RECENT UNIVERSITY OF COLORADO GRAND ROUNDS:
“Cerebrovascular Disease Gone Viral”
“The Emerging use of Statins in Cerebrovascular Disease”
“Carotid Endarterectomy: An Emerging Consensus Fibromuscular Dysplasia”
“Polycystic Kidney Disease and Intracranial Aneurysms”
“CNS Vasculitis Thrombolytic Therapy in Acute Stroke New Directions in Stroke Resuscitation”
“Are You Ready for Combination Therapy?”
“Unruptured Intracranial Aneurysms”
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“Iatrogenic Complications of Stroke Therapy”
“Advocacy, Lobbying, and the 2002 Colorado Stroke Bill “
“The Spectrum of Moya-Moya Disease in the Adult”
“Are You Ready For Stroke Center Certification?”
“Stroke Retrospective 1986-2006”
“Susac’s Syndrome”
“Call-Fleming Syndrome”
“Reducing Cardiac Embolization to the Brain: Are We Getting Near the Finish Line?”
“Insulin Resistance in Stroke Prevention: The NIH IRIS Trial Results”
REGULAR CONFERENCE TALKS:
Acute Neurology Series, UCHSOM
MS2 Neuropathology Course, UCSOM
MS4 Pharmacology, UCSOM (winter)
Residency Core Topics, UCSOM (on-going)
Resident Noon Reports
Stroke Fellow Weekly Core Lecture Series
Stroke Update for Internal Medicine, UCH & DHMC
MEDIA:
DATE: MEDIUM: TOPIC:
2010 Channel 31 Fox – Kim Posey Meningitis
2009 Fitness Magazine Fibromuscular Dysplasia
2007 Stroke Connection Fibromuscular Dysplasia
2004 Channel 31 Fox – Kim Posey “Brain Matters”
2004 Rocky Moun6tain News Migraines
2001 Bottom Line “Stroke Self-Defense”
2001 Channel 2 “Hyperbaric Oxygen in Stroke”
2001 KUSA TV “Train to End Stroke”
2000 KUSA TV “Operation Stroke”
2000 NSA Audio Tape and CD Stroke Guidelines
1999 KUSA Radio Atrial Fibrillation
1999 Fox Television News Hypothermia
1999 Bottom Line Magazine Atrial Fibrillation
1999 Tomorrow Magazine Atrial Fibrillation
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1999 Bottom Line Magazine Facial Tics
1999 Stroke-CD NSA
1999 USA Today Stroke Prevention
1999 NSA Video Stroke
1998 Prevention Magazine Atrial Fibrillation
1998 NSA-SCN-Audio Teleconference Moderator
1997 KUSA TV “Taco Neck”
1997 KUSA TV “Pokeman” Induced Seizures
1997 Internal Medicine News Minimum Requirements for TPA Use
1997 Boulder Daily Camera Stroke
1996 Denver Post Aneurysm
1996 AARP Video Stroke
1993 National Stroke Association, 1994
20 minute video
Stroke: The Story of Treatment and
Recovery. A 20-minute video, discussing
aspects of treatment and prognosis after a
stroke. Featuring Dr. Richard Hughes
and stroke-survivor Jackie Meyer-
Townsend, Miss America 1963
STUDY CONSULTING:
Amgen: Data Management and Safety Committee. Stem Cell treatment after Stroke 2010-2012
Nestle Life Sciences: Advisory Committee. Dysphagia 2015-present
STUDY PARTICIPATION:
Grants and Funding
Funding Source (estimate) Multi-Center Studies
NIH / Yale 2005-2013 Insulin Resistance Intervention After Stroke (IRIS)
Richard L. Hughes MD (PI Denver)
NIH ($275,000) Warfarin Versus Aspirin in Reduced Ejection Fraction (WARCEF)
2003-2012 Richard L. Hughes MD (PI Denver)
Lilly USA, LLC Duloxetine in Patients with Central Neuropathic Pain in Multiple Sclerosis -
Richard L. Hughes MD (PI Denver)
Merck Thrombin Receptor Antagonist in Secondary Prevention of
Atherothrombotic Ischemic Events (TRASP)
Richard L. Hughes MD (PI Denver)
Boehringer-Ingelheim Prevention Regimen for Effectively Avoiding Second Strokes
2003-2008 ($120,000) (PROFESS) - Richard L. Hughes MD (PI Denver)
Parke-Davis ($40,000) Stroke Prevention by Aggressive Reduction in Cholesterol levels
1999-2004 (SPARCL) - Richard L. Hughes MD (PI Denver)
Novo Nordisc ($10,000) Factor VII in Treatment of Cerebral Hemorrhage (FAST)
Richard L. Hughes MD (PI Denver)
NIH ($138,576) Vitamin Intervention in Stroke Prevention (VISP)
Richard L. Hughes, MD - Page 10 of 21
1998-2004 Richard L. Hughes MD (PI Denver)
Genentech ($60,000) Thrombolytic Therapy in Acute Ischemic Stroke
1992-2000 ATLANTIS - Richard L. Hughes MD (PI Denver)
NIH ($20,000) International Study of Unruptured Intracranial Aneurysms (ISUIA)
1992-2000 Richard L. Hughes MD (PI Denver)
HCFA $0 Appropriateness of Carotid Endarterectomy
Richard L. Hughes MD - Panelist
Jannsen terminated PACT (Prosynap Alteplase Combined Therapy)
1997-1999 Richard L. Hughes MD (PI Denver)
ICOS terminated HU23F26 Anti-adhesion to Limit Cytotoxic Injury in Stroke (HALT)
Richard L. Hughes MD (PI Denver)
Lorex ($17,000) Eliprodil in Ischemic Stroke (1995-1997)
1995-1996 Richard L. Hughes MD (PI Denver)
Santofi ($150,000) Clopidigrel vs. Aspirin in Prevention of Recurrent Ischemic Events
1992-1997 (CAPRIE) - Richard L. Hughes MD (PI Denver)
NIH ($12,000) Asymptomatic Carotid Atherosclerosis Study (ACAS)
1989-1991 Ochsner Richard L. Hughes MD (PI New Orleans)
Miles ($55,000) Nimodipine Stroke Study
1988-1990 Richard L. Hughes MD (PI New Orleans)
AUTHORIZED AND CONSORTIUM PUBLICATIONS:
1. Hughes RL: Medical overview of brain death. Health Care Review; 3(1):6-9, 1986
2. Hughes RL, Katirji B: The Eaton-Lambert (Myasthenic) Syndrome in Association with Systemic Lupus
Erythematosus. Arch Neurol 43:1186-87, 1986
3. Rosenberg NL, Hughes RL: Meningovascular Syphilis in a Young Homosexual Man. Arch Neurol
1989; 46:10-11
4. Hughes RL, Yonas H, Gur D, Latchaw R: Cerebral blood flow determination within the first 8 hours of
cerebral infarction using stable Xenon-enhanced computed tomography. Stroke 1989; 20:754-760
5. The Hemodilution in Stroke Study Group: Hypervolemic hemodilution treatment of acute stroke.
Results of a randomized multicenter trial using pentastarch. Stroke 1989 Mar; 20(3):317-23. (Hughes
RL, Denver)
6. Hass WK, Easton JD, Adams HP, Pryse-Phillips W, Molony BA, Anderson S, Kamm B: For the
Ticlopidine Aspirin Stroke Study Group. A randomized trial comparing ticlopidine hydrochloride with
aspirin for the prevention of stroke in high-risk patients. NEJM 1989; 321:501-507. (Hughes RL,
Pittsburgh and Denver)
Richard L. Hughes, MD - Page 11 of 21
7. Hughes RL: Identification and treatment of unruptured cerebral aneurysm after sentinel headache:
Report of two cases. Neurology 1992; 42:1118-1119
8. Chapman AB, Rubinstein DR, Hughes RL, Stears JC, Earnest MP, Johnson AM, Gabow PA and
Kaehny WD: Intracranial aneurysms in autosomal dominant polycystic kidney disease: A prospective
study. NEJM 1992; 327:916-920
9. The American Nimodipine Study Group: Clinical Trial of Nimodipine in Acute Ischemic Stroke.
Stroke 1992; 23:3-8 (Hughes RL, Primary Investigator, Ochsner Clinic)
10. McCrory DC, Goldstein LB, Sands GP, Oddone ET, Landsman PB, Moore WS, Matchar DB: Predicting
complications of carotid endarterectomy. Stroke 1993; 24:1285-1291. (Hughes RL, Alton Ochsner
Medical Foundation)
11. Goldstein LB, McCrory DC, Landsman PB, Samsa GP, Ancukiewicz M, Oddone EZ, Matchar DB:
Multicenter review of preoperative risk factors for carotid endarterectomy in patients with ipsilateral
symptoms. Stroke 1994; 25:1116-1121. (Hughes RL, Alton Ochsner Medical Foundation)
12. Brott T, Tomick T, Feinberg W, Johnson C, Biller J, Broderick J, Kelly M, Frey J, Schwartz S, Blum C,
Nelson JJ, Chambless L, Toole J, for the Asymptomatic Carotid Atherosclerosis Study Investigators:
Baseline Silent Cerebral Infarction in the Asymptomatic Carotid Atherosclerosis. Stroke 1994; 25:1116-
1121. (Hughes RL, Primary Investigator, Oschner Clinic, New Orleans, LA)
13. The Asymptomatic Carotid Atherosclerosis (ACAS) Study Group. Endarterectomy for Asymptomatic
Carotid Artery Stenosis. JAMA 273:1421-1428 1995; (Hughes, RL, Primary Investigator, Oschner
Clinic, New Orleans, LA)
14. Howard G, Baker WH, Chambless LE, Howard V, Jones AM, Toole JF, for the Asymptomatic Carotid
Atherosclerosis Study Investigators: An Approach for the Use of Doppler Ultrasound as a Screening
Tool for Hemodynamically Significant Stenosis (Despite Heterogeneity of Doppler Performance). Stroke
1996; 27:1951-1957. (Hughes RL, Primary Investigator, Oschner Clinic, New Orleans, LA)
15. Young B, Moore WS, Robertson JT, Toole JF, Ernst CB, Cohen SN, Broderick JP, Dempsey RJ,
Hosking JD; for the ACAS Investigators: An Analysis of Perioperative Surgical Mortality and
Morbidity in the Asymptomatic Carotid Atherosclerosis Study. Stroke 1996; 27:2216-2224. (Hughes
RL, Primary Investigator, Oschner Clinic, New Orleans, LA)
16. CAPRIE steering Committee: A randomized, blinded, trial of clopidogrel versus aspirin in patients at
risk of ischemic events (CAPRIE). Lancet 1996; 348:1329-1338. (Hughes RL, Primary Investigator,
Denver)
17. Ringel SR, Hughes RL: Evidence-based medicine, critical pathways, practice guidelines, and managed
care, reflections on the prevention and care of stroke. Arch Neurol 1996; 53:867-871
18. Karanjia PN, Nelson JJ, Lefkowitz DS, Dick AR, Toole JF, Chamblers LE, Hayes R, Howard VJ:
Validation of the ACAS TA/Stroke Algorithm. Neurology 1997; 48:346-351 (Hughes RL, University of
Colorado)
19. Moore WS, Kempczinski RF, Nelson JJ, Toole JF, for the ACAS Investigators: Recurrent Carotid
Stenosis Results of the Asymptomatic Carotid Atherosclerosis Study: Stroke 1998; 29:2018-2025.
(Hughes RL, Primary Investigator, Ochsner Clinic, New Orleans, LA)
Richard L. Hughes, MD - Page 12 of 21
20. Alberts MJ, Chaturvedi S, Graham G, Hughes RL, Jamieson DG, Krakowski F, Raps E, Scott P, for the
National Acute Stroke Team Group. Acute Stroke Teams: Results of a national survey. Stroke 1998;
29:2318-20
21. International Study of Unruptured Intercranial Aneurysms (ISUIA) Investigators: Unruptured
intracranial aneurysms. Risk of rupture and surgery. NEJM 1998; 339:1725-33. (Hughes RL, Primary
Investigator, Denver)
22. Munschauer FE, Hens MM, Priore RL, Stolarski E, Buffamonte S, Carlin A, Wechsler L, Massaro L,
Barch C, Hughes RL, Anderson A, Sung G, Baker S, Limon S: Screening for atrial fibrillation in the
community: A multicenter validation trial. J Stroke and Cerebrovascular Dis 1999; 8:99-103
23. Kramer AM, Kowalsky L, Cahill J, Lin M, Grigsby J, Hughes RL, and Steiner JF: Outcome and
utilization differences for older persons with stroke in HMO and fee-for-service systems. J Am Geriatr
Soc 2000; 48:726-734
24. Clark WM, Albers GW, Madden KP, Hamilton S: The rtPA 0-to 6-hour acute stroke trial, part A
(A0276g) results of a double-blind, placebo-controlled, multicenter study. Stroke 2000; 31:811-816.)
(Hughes RL, Primary Investigator, Denver)
25. Spence JD, Howard VJ, Chambless LE, Malinow MR, Pettigrew LC, Stampfer M, Toole JF for the VISP
Investigators: Vitamin Intervention for Stroke Prevention (VISP) Trial: Rationale and Design.
Neuroepidemiology 2001; 20:16-25
26. Belz MM, Hughes RL, Kaehny WD, Johnson AM, Fick-Brosnahan GM, Earnest MP, Gabow PA:
Familial Custering of Ruptured Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney
Disease. American Journal of Kidney Diseases 2001; 38:770-776
27. Hughes RL: Multidisciplinary Consensus Recommendations from the Advisory Working Group on
Stroke Center Identification Options of the American Stroke Association. Recommendations for
Improving the Quality of Care through Stroke Centers and Systems: An Examination of Stroke Center
Identification Options. Stroke 2002; 33:e1-e7
28. Belz MM, Godela M, Fick-Brosnahan GM, Hughes RL, Rubinstein D, Chapman AB, Johnson AM,
McFann KK, M.Div., Kaehy WD, Gabow PA: Recurrence of Intracranial Aneurysms in Autosomal
Dominant Polycystic Kidney Disease. Kidney International 2003; 63:1824-30
29. D.A. Hall, MD, C.A. Anderson, MD, C.M. Filley, MD, J Newcombe, MA, C.C.C.S.L.P, Hughes RL: A
French Accent after an Infarct in the Corpus Callosum. Neurology 2003; 60:1551-2
30. Hughes RL, Halm EA, Chassin MR, Tuhrim S, Hollier LH, Popp AJ, Ascher E, Dardik H, Faust G,
Riles TS: Revisiting the Appropriateness of Carotid Endarterectomy. Stroke 2003; 34:1464-1472
31. Englander J, Bushnik T, Duong TT, Cifu D, Zafonte R, Wright J, Hughes RL, Bergman W: Analyzing
risk factors for late posttraumatic seizures: a prospective multicenter study. Arch Phys Med Rehabil
2003; 84:365-73
32. Amarenco P, Bobousslavsky J, Callahan AS, Goldstein L, Hennerici M, Sillsen H, Welch MA, Zivin J,
SPARCL Investigators: Design and baseline characteristics of stroke prevention by aggressive
reduction in cholesterol levels (SPARCL). Cerebrovasc Dis 2003; 16:389-95
Richard L. Hughes, MD - Page 13 of 21
33. Weibers D, and the International Study of Unruptured Intracranial Aneurysm Investigators:
Unruptured intracranial aneurysms: natural history, clinical outcome, and risk of surgical and
endovascular treatment. Lancet 2003; 362:103-110
34. Toole JF, Malinow MR, Chambless LE, Spence JD, Spence LC, Pettigrew LC, Howard VJ, Sides EG,
Wang CH, Stampfer M: Lowering homocysteine in patients with ischemic stroke to prevent recurrent
stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP)
randomized controlled trial. JAMA 2004; 291:565-75. (Hughes RL, Denver)
35. Shrier RW, Belz MM, Johnson AM, Kaehny WD, Hughes RL, Rubinstein D, Gabow PA: Repeat
Imaging for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease
with Initially Negative Studies: A Prospective Ten-Year Follow-up. J Am Soc Nephrol 2004, Volume
15, 1023-8
36. The Stroke Prevention by Aggressive Reduction in Cholesterol SPARCL Investigators: High-Dose
Atorvastatin after Stroke or Transient Ischemic Attack. NEJM 2006; 355:549-559
37. Pullicino P, Thompson JL, Barton B, Levin B, Graham S, Freudenberger RS, WARCEF Investigators:
Warfarin versus aspirin in patients with reduced cardiac ejection fraction (WARCEF): rationale,
objectives, and design. J Card Fail 2006 Feb; 12(1):39-46
38. Amarenco P, Goldstein LB, Szarek M, Sillesen H, Rudolph AE, Callahan A III, Hennerici M, Simunovic
L, Zivin JA, Welch MA on behalf of the SPARCL Investigators: Effects of Intense Low-Density
Lipoprotein Cholesterol Reduction in Patients with Stroke or Transient Ischemic Attack: The Stroke
Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial Stroke 2007; 38:3198-3204
39. Kluger BM, Hughes RL, Anderson CA, Hassell KL: Non-traumatic carotid dissection and stroke
associated with anti- phospholipid antibody syndrome: Report of a case and review of the literature.
Neurol India 2008; 56:77-8
40. Ralph L. Sacco, MD, Hans Christoph Diener, MD, PhD, Salim Yusuf, MB, BS, D. Phil, Daniel Cotton,
MS, Stephanie Ôunpuu, PhD, William A. Lawton, BA, Yuko Palesch, PhD, Reneé H. Martin, PhD,
Gregory W. Albers, MD, Philip Bath, FRCP, Natan Bornstein, MD, Bernard P.L. Chan, MD, Sien-Tsong
Chen, MD, Luis Cunha, MD, PhD, Björn Dahlöf, MD, PhD, Jacques De Keyser, MD, PhD, Geoffrey A.
Donnan, MD, Conrado Estol, MD, PhD, Philip Gorelick, MD, Vivian Gu, MD, Karin Hermansson,
DMSc, Lutz Hilbrich, MD, Markku Kaste, MD, PhD, Chuanzhen Lu, MD, Thomas Machnig, MD, Prem
Pais, MD, Robin Roberts, M.Tech, Veronika Skvortsova, MD, Philip Teal, MD, Danilo Toni, MD, Cam
VanderMaelen, PhD, Thor Voigt, MD, Michael Weber, MD, Byung-Woo Yoon, MD, PhD, for the
PROFESS Study Group*: Aspirin and Extended-Release Dipyridamole versus Clopidogrel for
Recurrent Stroke. N Engl J Med 2008; 359:1238-1251
41. Salim Yusuf, MB, BS, D. Phil, Hans-Christoph Diener, MD, PhD, Ralph L. Sacco, MD, Daniel Cotton,
MS, Stephanie Ôunpuu, PhD, William A. Lawton, BA, Yuko Palesch, PhD, Reneé H. Martin, PhD,
Gregory W. Albers, MD, Philip Bath, FRCP, Natan Bornstein, MD, Bernard P.L. Chan, MD, Sien-Tsong
Chen, MD, Luis Cunha, MD, PhD, Björn Dahlöf, MD, PhD, Jacques De Keyser, MD, PhD, Geoffrey A.
Donnan, MD, Conrado Estol, MD, PhD, Philip Gorelick, MD, Vivian Gu, MD, Karin Hermansson,
DMSc, Lutz Hilbrich, MD, Markku Kaste, MD, PhD, Chuanzhen Lu, MD, Thomas Machnig, MD, Prem
Pais, MD, Robin Roberts, M.Tech., Veronika Skvortsova, MD, Philip Teal, MD, Danilo Toni, MD, Cam
VanderMaelen, PhD, Thor Voigt, MD, Michael Weber, MD, Byung-Woo Yoon, MD, PhD, for the
PROFESS Study Group: Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events N Eng J
Med 2008; 359:1225-1237
Richard L. Hughes, MD - Page 14 of 21
42. Larry B. Goldstein, MD; Pierre Amarenco, MD; Marian LaMonte, MD; Steven Gilbert, PhD; Michael
Messig, PhD; Alfred Callahan, MD; Michael Hennerici, MD, PhD; Henrik Sillesen, MD, MSc; K.
Michael A. Welch, MB, ChB on behalf of the SPARCL Investigators: Relative Effects of Statin
Therapy on Stroke and Cardiovascular Events in Men and Women: Secondary Analysis of the Stroke
Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study. Stroke 2008: 39:2444-
2448
43. Henrik Sillesen, Pierre Amarenco, Michael G. Hennerici, Alfred Callahan, Larry B. Goldstein, Justin
Zivin, Michael Messig, Michael Welch on Behalf of the SPARCL Investigators: Atorvastatin Reduces
the Risk of Cardiovascular Events in Patients with Carotid Atherosclerosis: A Secondary Analysis of the
Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial. Stroke 2008;
39:3297-3302
44. L. B. Goldstein, MD, P. Amarenco, MD, M. Szarek, MS, A. Callahan, III, MD, M. Hennerici, MD, PhD,
H. Sillesen, MD, DMSc, J. A. Zivin, MD, PhD, K.M.A. Welch, MD, PhD on behalf of the SPARCL
Investigators: Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol
Levels study. Neurology 2008; 70:2364-2370
45. Chaturvedi S, Zivin J, Beazna Amarenco P, Callahan A, Goldstein LB, Hennerici M, Sillesen H,
Rudolph A, Welch MA on behalf of the SPARCL Investigators: Effect of atorvastatin in elderly
patients with a recent stroke or transient ischemic attack. Neurology 2009; 72:688-694
46. Pierre Amarenco, Oscar Benavente, Larry B. Goldstein, Alfred Callahan, III, Henrik Sillesen, Michael
G. Hennerici, Steve Gilbert, Amy E. Rudolph, Lisa Simunovic, Justin A. Zivin, K. Michael A. Welch on
behalf of the SPARCL Investigators: Results of the Stroke Prevention by Aggressive Reduction in
Cholesterol Levels (SPARCL) Trial by Stroke Subtypes. Stroke 2009; 40:1405-1409
47. Larry B. Goldstein, Pierre Amarenco, Justin Zivin, Michael Messig, Irfan Altafullah, Alfred Callahan,
Michael Hennerici, Mary J. MacLeod, Henrik Sillesen, Richard Zweifler, K. Michael, A. Welch on
behalf of the SPARCL Investigators: Statin Treatment and Stroke Outcome in the Stroke Prevention by
Aggressive Reduction in Cholesterol Levels (SPARCL) Trial. Stroke 2009; 40:3526-3531
48. Philip M. W. Bath, Reneé H. Martin, Yuko Palesch, Daniel Cotton, Salim Yusuf, Ralph Sacco, Hans-
Christoph Diener, Danilo Toni, Conrado Estol, Robin Roberts for the PROFESS Study Group: Effect
of Telmisartan on Functional Outcome, Recurrence, and Blood Pressure in Patients With Acute Mild
Ischemic Stroke: A PROFESS Subgroup Analysis. Stroke 2009; 40:3541-3546
49. Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR,
Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W; ECASS, ATLANTIS, NINDS and
EPITHET rt-PA Study Group, Allen K, Mau J, Meier D, del Zoppo G, De Silva DA, Butcher KS,
Parsons MW, Barber PA, Levi C, Bladin C, Byrnes G. for the ECASS, ATLANTIS, NINDS and
EPITHET rt-PA Study Group Investigators: Time to treatment with intravenous alteplase and
outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.
Lancet 375:1695-1703, 15 May 2010; Collaborators (752)
50. Bath PM, Cotton D, Martin RH, Palesch Y, Yusuf S, Sacco R, Diener HC, Estol C, Roberts R;
PROFESS Study Group: Effect of combined aspirin and extended-release dipyridamole versus
clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PROFESS subgroup
analysis. Stroke 2010 Apr; 41(4):732-8
Richard L. Hughes, MD - Page 15 of 21
51. Ovbiagele B, Diener HC, Yusuf S, Martin RH, Cotton D, Vinisko R, Donnan GA, Bath PM; PROFESS
Investigators: Level of systolic blood pressure within the normal range and risk of recurrent stroke.
JAMA 2011 Nov 16; 306(19):2137-44
52. Weber R, Weimar C, Wanke I, Möller-Hartmann C, Gizewski ER, Blatchford J, Hermansson K,
Demchuk AM, Forsting M, Sacco RL, Saver JL, Warach S, Diener HC, Diehl A; PROFESS Imaging
Substudy Group: Risk of recurrent stroke in patients with silent brain infarction in the Prevention
Regimen for Effectively Avoiding Second Strokes (PROFESS) imaging substudy. Stroke 2012 Feb;
43(2):350-5. Epub 2012 Jan 19
53. Braun CN, Hughes RL, Bosque PJ: Reversible Cerebral Vasoconstriction Syndrome 3 Months after
Blood Transfusion. J Stroke Cerebrovasc Dis. 2012 Feb 15. [Epub ahead of print]
54. David A. Morrow, M.D., M.P.H., Eugene Braunwald, M.D., Marc P. Bonaca, M.D., Sebastian F.
Ameriso, M.D., Anthony J. Dalby, M.B., Ch.B., Mary Polly Fish, B.A., Keith A.A. Fox, M.B., Ch.B.,
Leslie J. Lipka, M.D., Ph.D., Xuan Liu, Ph.D., José Carlos Nicolau, M.D., Ph.D., A.J. Oude Ophuis,
M.D., Ph.D., Ernesto Paolasso, M.D., Benjamin M. Scirica, M.D., M.P.H., Jindrich Spinar, M.D., Ph.D.,
Pierre Theroux, C.M., M.D., Stephen D. Wiviott, M.D., John Strony, M.D., and Sabina A. Murphy,
M.P.H. for the TRA 2P–TIMI 50 Steering Committee and Investigators: Vorapaxar in the Secondary
Prevention of Atherothrombotic Events. N Engl J Med 2012; 366:1404-1413 April 12, 2012
55. Shunichi Homma, M.D., John L.P. Thompson, Ph.D., Patrick M. Pullicino, M.D., Bruce Levin, Ph.D.,
Ronald S. Freudenberger, M.D., John R. Teerlink, M.D., Susan E. Ammon, N.P., Susan Graham, M.D.,
Ralph L. Sacco, M.D., Douglas L. Mann, M.D., J.P. Mohr, M.D., Barry M. Massie, M.D., Arthur J.
Labovitz, M.D., Stefan D. Anker, M.D., Ph.D., Dirk J. Lok, M.D., Piotr Ponikowski, M.D., Ph.D.,
Conrado J. Estol, M.D., Ph.D., Gregory Y.H. Lip, M.D., Marco R. Di Tullio, M.D., Alexandra R.
Sanford, M.S., Vilma Mejia, B.S., Andre P. Gabriel, M.D., Mirna L. del Valle, B.S., and Richard
Buchsbaum for the WARCEF Investigators: Warfarin and Aspirin in Patients with Heart Failure and
Sinus Rhythm. N Engl J Med 2012; 366:1859-1869 May 17, 2012
56. David A. Morrow, Mark J. Alberts, Jay P. Mohr, Sebastian F. Ameriso, Marc P. Bonaca, Shinya Goto,
Graeme J. Hankey, Sabina A. Murphy, Benjamin M. Scirica, and Eugene Braunwald, for the Thrombin
Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering
Committee and Investigators: Efficacy and Safety of Vorapaxar in Patients with Prior Ischemic Stroke.
Stroke 2013; 44:691-698, published online before print February 8 2013,
doi:10.1161/STROKEAHA.111.000433
57. Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, Gorman M, Guarino PD, Inzucchi SE,
Lovejoy AM, Parsons MW, Peduzzi PN, Ringleb P, Schwartz GG, Spence JD, Tanne D, Young LH,
Kernan WN on behalf of the IRIS Trial Investigators: Pioglitazone for secondary prevention after
ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance
Intervention after Stroke (IRIS). Am Heart J 2014:168:823-829
58. Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, Gorman M, Guarino PD, Inzucchi SE,
Lovejoy AM, Parsons MW, Peduzzi PN, Ringleb PA, Schwartz GG, Spence JD, Tanne D, Young LH,
Kernan WN, IRIS Trial investigators: Pioglitazone for secondary prevention after ischemic stroke and
transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial.
Am Heart J. (2014)
59. Case D, Seinfeld J, Folzenlogen Z, Simpson J, Hughes RL: Acute posterior Multifocal Placoid Pigment
Epitheliopathy associated with Stroke: A Case Report and review. Journal of Stroke and Cerebrovascular
Diseases 2015 24:e295-302
Richard L. Hughes, MD - Page 16 of 21
60. Borah S, McConnell B, Hughes RL, Antoniello D, and Kluger B: Potential Relationship of Self-
Injurious Behavior to Right Temporo-Parietal Lesions. Under Review
61. Keenan WN et al.: Insulin Resistance Intervention in Stroke Trial. N Engl J Med 2016. doi:10:1056/NEJ
Moa1 56930
62. Xu J, Viscoli CM, Ford GA, Gorman M, Kernan WN, IRIS Trial Investigators: A Diagnostic Score for
Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack. J Stroke
Cerebrovasc Dis. 2016 Jul;25(7):1705-1712. doi: 10.1016/j.jstrokecerebrovasdis.2016.03.043. Epub
2016 Apr 11
63. Inzucchi SE, Viscoli CM, Young LH, Furie KL, Gorman M, Lovejoy AM, Dagogo-Jack S, Ismail-Beigi
F, Korytkowski MT, Pratley RE, Schwartz GG, Kernan WN, IRIS Trial Investigators: Pioglitazone
Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care. 2016
Oct;39(10):1684-92. doi: 10.2337/dc16-0798. Epub 2016 Jul 27
64. Viscoli CM, Inzucchi SE, Young LH, Insogna KL, Conwit R, Furie KL, Gorman M, Kelly MA, Lovejoy
AM, Kernan WN, IRIS Trial Investigators: Pioglitazone and Risk for Bone Fracture: Safety Data From
a Randomized Clinical Trial. J Clin Endocrinol Metab. 2017 Mar 1;102(3):914-922. doi:
10.1210/jc.2016-3237. PMID: 27935736; PubMed Central PMCID: PMC5460686
65. Young LH, Viscoli CM, Curtis JP, Inzucchi SE, Schwartz GG, Lovejoy AM, Furie KL, Gorman MJ,
Conwit R, Abbott JD, Jacoby DL, Kolansky DM, Pfau SE, Ling FS, Kernan WN, IRIS Investigators:
Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in
Patients With Insulin Resistance Without Diabetes Mellitus. Circulation. 2017 May 16;135(20):1882-
1893. doi: 10.1161/CIRCULATIONAHA.116.024863
66. Saver JL, Carroll JD, Thaler DE, Smalling RW, MacDonald LA, Marks DS, Tirschwell DL; RESPECT
Investigators: Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.
N Engl J Med. 2017 Sep 14;377(11):1022-1032. doi: 10.1056/NEJMoa1610057
67. Furie KL, Viscoli CM, Gorman M, Ford GA, Young LH, Inzucchi SE, Guarino PD, Lovejoy AM,
Conwit R, Tanne D, Kernan WN; IRIS Trial Investigators: Effects of pioglitazone on cognitive
function in patients with a recent ischaemic stroke or TIA: a report from the IRIS trial. J Neurol
Neurosurg Psychiatry. 2017 Sep 22. pii: jnnp-2017-316361. doi: 10.1136/jnnp-2017-316361
68. Yaghi S, Furie KL, Viscoli CM, Kamel H, Gorman M, Dearborn J, Young LH, Inzucchi SE, Lovejoy
AM, Kasner SE, Conwit R, Kernan WN, IRIS Trial Investigators: Pioglitazone Prevents Stroke in
Patients with a Recent TIA or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial.
Circulation. 2017 Oct 30. pii: CIRCULATIONAHA.117.030458. doi:
10.1161/CIRCULATIONAHA.117.030458
69. Epstein KA, Viscoli CM, Spence JD, Young LH, Inzucchi SE, Gorman M, Gerstenhaber B, Guarino PD,
Dixit A, Furie KL, Kernan WN; IRIS Trial Investigators: Smoking Cessation and Outcome After
Ischemic Stroke or TIA. Neurology 2017 Oct 17;89(16):1723-1729. doi:
10.1212/WNL.0000000000004524. Epub 2017 Sep 8. PubMed PMID: 28887378; PubMed Central
PMCID: PMC5644463
70. Kernan WN, Viscoli CM, Dearborn JL, Kent DM, Conwit R, Fayad P, Furie KL, Gorman M, Guarino
PD, Inzucchi SE, Stuart A, Young LH, IRIS Trial Investigators: Insulin Resistance Intervention After
Stroke: Targeting Pioglitazone Hydrochloride Therapy After Stroke or Transient Ischemic Attack
Richard L. Hughes, MD - Page 17 of 21
According to Pretreatment Risk for Stroke or Myocardial Infarction. JAMA Neurol. 2017 Nov
1;74(11):1319-1327. doi: 10.1001/jamaneurol.2017.2136
71. Kernan WN, Viscoli CM, Dearborn JL, Kent DM, Conwit R, Fayad P, Furie KL, Gorman M, Guarino
PD, Inzucchi SE, Stuart A, Young LH, IRIS Trial Investigators: Insulin Resistance Intervention After
Stroke. JAMA Neurol. 2017 Nov 1;74(11):1319-1327. doi: 10.1001/jamaneurol.2017.213
BOOK CHAPTERS:
1. Hughes RL: “CBF Determination Within the First Eight Hours of Cerebral Infarction.” In Yonas HW,
ed. Cerebral Blood Flow Measurement with Stable Xenon-enhanced Computed Tomography. New York:
Raven Press, 1992:121-125
2. Hughes RL: “Neurology.” In Frolich E, ed. Rypian Medical Board Review. Clinical Sciences. 16th
edition. J.P. Lippencott, Philadelphia, 1992
3. Hughes RL, Earnest MP: “Transient Ischemic Attack and Cerebrovascular Accident.” In Markovchick
VJ, Pons PT, and Wolfe RE, eds. Emergency Medicine Secrets. Hanley and Belfur Inc, Philadelphia,
1993
4. Anderson CA, Hughes RL: “Tremor, Common Disorders of the Nervous System.” Primary Care
Secrets. Mosby, 1994, pp 311-313
5. Foley PA, Hughes, RL: “Muscle Weakness, Common Disorders of the Nervous System.” Primary Care
Secrets. Mosby, 1994, pp 313-316
6. Redosh D, Hughes RL: “Numbness and Tingling, Common Disorders of the Nervous System.” Primary
Care Secrets. Mosby, 1994, pp 316-318
7. Villalobos R, Hughes RL: “Cerebrovascular Disorders, Common Disorders of the Nervous System.”
Primary Care Secrets. Mosby, 1994, pp 319-320
8. Hughes RL, Ravilochan K: “Dizziness and Syncope, Common Disorders of the Nervous System.”
Primary Care Secrets. Mosby, 1994, pp 323-326
9. Kumpe D, Hughes RL: “Thrombolytic Therapy for Acute Stroke.” In Whittemore AD ed, Advances in
Vascular Surgery. Mosby, 1996
10. Hughes RL: “Cerebrovascular Disease.” In Jahnigen D, Schrier R eds, Geriatrics. Blackwell, 1996
11. Anderson CA, Hughes RL: “Tremor.” In Mladenovic J ed. Primary Care Secrets. 2nd edition. Hanley
and Belfus, Philadelphia, 1998 Chapter 77
12. Ferguson MA, Hughes RL: “Muscle Weakness.” In Mladenovic J ed. Primary Care Secrets. 2nd edition.
Hanley and Belfus, Philadelphia, 1998 Chapter 78
13. Ferguson MA, Hughes RL: “Numbness and Tingling.” In Mladenovic J ed. Primary Care Secrets. 2nd
edition. Hanley and Belfus, Philadelphia, 1998 Chapter 79
14. Anderson CA, Hughes RL: “Cerebrovascular Disorders.” In Mladenovic J ed. Primary Care Secrets. 2nd
edition. Hanley and Belfus, Philadelphia, 1998 Chapter 80
Richard L. Hughes, MD - Page 18 of 21
15. Distad DJ, Hughes RL: “Dizziness and Syncope.” In Mladenovic J ed. Primary Care Secrets. 2nd
edition. Hanley and Belfus, Philadelphia, 1998 Chapter 82
16. Shrestha A, Hughes RL: “Seizure Disorders.” In Mladenovic J ed: Primary Care Secrets. 2nd edition.
Hanley and Belfus, Philadelphia, 1998 Chapter 83
17. Liang B, Hughes RL. “Clinical Science.” Hospital Practice Board Review Manual. 1998; 1:35-42
18. Anderson CA, Hughes RL: “Cerebrovascular Disease.” In Markovchick V ed. Emergency Medicine
Secrets. Hanley and Belfus, Philadelphia. 1998 Chapter 21
19. Hughes RL, Anderson CA, Sung GA: “Diagnostic Evaluation and Medical Management of Patients
with Ischemic Cerebrovascular Disease.” In Rutherford RB, ed. Vascular Surgery. 5th edition. Sanders,
Philadelphia, 1999 Chapter 128
20. Hughes RL, Earnest MP, “Transient Ischemic Attacks and Cerebrovascular Accident.” In Markovchick
VJ, Pons PT Emergency Medicine Secrets. 2002
21. FMD, Wilson J, Hughes RL: “Fibromuscular dysplasia.” eMedicine Journal, October 10, 2003
22. Hughes RL, C. Alan Anderson, “Tremor. Common Disorders of the Nervous System.” Primary Care
Secret. 3rd edition. Jeanette Mladnovic, MD 2004
23. Hughes RL, Michele A. Ferguson, “Muscle Weakness. Common Disorders of the Nervous System.”
Primary Care Secrets. 3rd edition. Jeanette Mladenovic, MD 2004
24. Hughes RL, Ferguson, MA, “Numbness and Tingling. Common Disorders of the Nervous System.”
Primary Care Secrets. 3rd edition. Jeanette Mladenovic, MD 2004
25. Hughes RL, C. Alan Anderson, “Cerebrovascular Disorders. Common Disorders of the Nervous
System.” Primary Care Secrets. 3rd edition. Jeanette Mladenovic, MD 2004
26. Hughes RL, Jane Distad, “Dizziness and Syncope. Common Disorders of the Nervous System.”
Primary Care Secrets. 3rd edition. Jeanette Mladenovic, MD 2004
27. Hughes RL, Achana Ahrestha, “Seizure Disorders. Common Disorders of the Nervous System.”
Primary Care Secrets. 3rd edition. Jeanette Mladneovic, MD 2004
28. Maa EA, Hughes RL. “Seizures in the ICU.” In: Albet RK, Ranieri M, Slutsky A, Takkala T, Torres T.
Clinical Critical Care Medicine. Mosby, Philadelphia. 2006 415-430
29. Hughes RL, Earnest MP, “Transient Ischemic Attacks and Cerebrovascular Accident.” In Markovchick
VJ, Pons PT Emergency Medicine Secrets. 2006
30. Wilson J, Hughes RL: “Fibromuscular dysplasia.” eMedicine Journal. Updated 2010
LETTERS, ABSTRACTS, AND OTHER PUBLICATIONS:
1. “The Magic Ninth,” A short story in The Alpha Centuri Communicator, 1977
2. Hughes RL: Letter to the Editor. NEJM 315:522, 1986
Richard L. Hughes, MD - Page 19 of 21
3. Hughes RL, Yonas H, Gur D, Latchaw R: Stable Xenon Enhanced CT in the First Eight Hours of
Cerebral Infarction. Stroke 1987; 18:283. (Abstract)
4. Yonas H, Hughes, RL, Hirsch WL, Latchaw RE, Gur D: Stable Xenon Enhanced CT Within the First
Eight Hours of Cerebral Infarction. Rad 1987; 165(P) Suppl: 40. (Abstract)
5. Hughes RL, Kaehny W, Earnest MP, Gabow PA: Intracranial Aneurysms in Autosomal Dominant
Polycystic Kidney Disease Show Familiar Clustering. Neurol 1988; 38 (Supp 1):131-2. (Abstract)
6. Hughes RL: Bluth EI: Relationship between carotid plaque hematoma and ischemic cerebrovascular
symptoms. Stroke 1988; 19:534. (Letter)
7. Bluth EI, Hughes RL: Importance of carotid artery plaque distribution and hemorrhage. Arch Neurol
1988; 45:602. (Letter)
8. Hughes RL: Ochsner JL: Preventing and Treating Stroke. Executive Health, fall 1989
9. Hughes RL: Cyclosporine related central nervous system toxicity in cardiac transplantation. NEJM
1990; 323:420-421
10. Hughes RL: Successful treatment of chronic misery perfusion with acetazolamide: report of six cases.
Neurology 1991; 41 (Suppl. 1):402. (Abstract)
11. Hughes, RL: NEJM 325:664, 1991. (Letter)
12. Hughes RL: Technetium 99 HMPAO Spect During an Episode of Transient Global Amnesia-A Case
Report. Stroke 1992; 23:463. (Abstract)
13. Ahmed L, Kramer A, Eckhoff D, Hughes RL, Eilertson T, Wallace H: Placement factors for elderly
stroke and hip fracture patients in acute rehabilitation or skilled nursing facility. J Am Geriatr Soc.
(Abstract)
14. Hughes, RL, Chapman A, Rubinstein D, et al: Recurrent Intracranial Aneurysms (ICA) in Autosomal
Dominant Polycystic Kidney Disease (ADPKD). Stroke 1996; 27:178. (Abstract)
15. Hughes RL, Corbey J, Liang B, Tyler B, and Ringel S: Residency restructuring for future resident
education: making difficult choices at the University of Colorado. Neurology 1997 48:A71
16. Hughes RL, Anderson CA, Kumpe D, Coldwell D: Selection of patients for intra-arterial CNS
procedures in the era of intravenous TPA. J of Stroke and Cerebrovascular Disease 1997, 6:472
17. Hughes RL, Smith D, Smith R, Lowther M: Creation of a regional organization to support stroke
resuscitation: The Colorado Acute Stroke Network (CASN). J of Stroke and Cerebrovascular Disease
1997, 6:471
18. Hughes RL, Grigsby J, Ahmed LA, Eilertson TB, Kramer AM: ADL Outcome of cortical stroke at one
year based on acute images. Stroke 1998; 29:317
19. Anderson A, Smith DB, Hughes RL: The Colorado Acute Stroke Network experience with intravenous
r-TPA in acute ischemic stroke. Neurology 1998; 50:A157
Richard L. Hughes, MD - Page 20 of 21
20. Torner JC, Wiebers DO, Brown RD, Whisnant JP: Factors Related to Location of Unruptured Cerebral
Aneurysms: Report of the International Study of Unruptured Intracranial Aneurysms (ISUIA)
Investigators. Stroke 1999; 30: 270. (Hughes RL, Denver, CO)
21. Clark WM, Albers GW, for the Atlantis Stroke Study Investigators: The Atlantis rt-PA (Alterplase)
Acute Stroke Trial: Final Results. Stroke 1999; 30: 234. (Hughes RL, Denver, CO)
22. Baker WH, Howard VJ, Howard G, Toole JF, for the ACAS Investigators: The Effect of Contralateral
Occlusion on Peri-operative and Late Stroke Rates in the Asymptomatic Carotid Atherosclerosis Study
(ACAS). Stroke 1999; 30: 242. (Hughes RL, Denver, CO)
23. Malinow MR, Chambless LE, Howard VJ, Toole JF, for the VISP Investigators: Screening of Plasma
Homocyst(e)ine Levels in Stroke Patients for the Vitamin Intervention for Stroke Prevention (VISP)
Clinical Trial. Stroke 1999; 30: 258. (Hughes RL, Denver, CO)
24. ISUIA Investigators, Mayo Clinic, Rochester, MN: Determinants of Intervention for Unruptured
Aneurysms Less than 10 MM in Diameter. Stroke 2000; 31:289
25. Grotta JC, Combination Therapy Stroke Trial: rt-PA +/-Lubeluzole Univ of Texas Medical School,
Houston, TX. Stroke 2000; 31:278 (Hughes RL, Denver, CO)
26. Sweeney C, Pelak V, Bennett J, Hughes RL: Delayed Onset of Optic Nerve Injury Following Cisplatin.
J of Neuro-Ophth 2000
27. Hughes RL, Frey LC: Magnesium Induced Hemorrhage after Successful Resuscitation of Stroke with IV
rTPA. World Stroke Congress. Melbourne, Australia. November 2000
28. Mueller DA, Anderson CA, Hughes RL, Newcombe J: Foreign Accent Syndrome Following a Stroke in
the Corpus Callosum. ANPA, San Diego. J Neuropsychiatry Clin Neurosci 14:1, 2002
29. Hughes RL: Aneurysms in Polycystic Kidney Disease. Neurosurgery in the Rockies, Vail CO, March
2002
30. Hughes RL: Successful Passage of Stroke Legislation in Colorado, USA. Stroke Society of Australia. Queensland, Australia. Sept 2-5, 2002
31. Hughes RL: Successful Passage of Stroke Legislation in Colorado. Western States Stroke Consortium.
Los Angeles, September 2002
32. Torner JC, Weiber DO, Piepgras D, Brown RD, and the ISUIA Investigators: Perioperative Cerebral
Infarction and Hemorrhage in Surgical Treatment of Unruptured Intracranial Aneurysms. Stroke 2003
34:246
33. Hughes RL: Rescreening of ADPKD Patients with initial negative screening. Neurosurgery in the Rockies, Vail, CO. March 2004
34. Hughes RL, The ASA/JCAHO Stroke Center certification initiative. Neurosurgery in the Rockies, Vail, CO March 2004
35. Hughes RL: Hypothermia in Ischemic Stroke. Neurosurgery in the Rockies, Vail, CO. February 2005
36. Hughes RL: Comprehensive Stroke Center Certification. Neurosurgery in the Rockies, Vail, CO
Richard L. Hughes, MD - Page 21 of 21
2006
37. Hughes RL: Stroke Center certification in the USA. Australasia Stroke Society, Adelaide, Australia 2006
38. Hughes RL: Neurosurgery in the Rockies; Emerging use of statins in cerebrovascular disease. Vail, CO 2007
39. Hughes RL: Comprehensive Stroke Update. Neurosurgery in the Rockies. Beaver Creek, CO 2010
40. Hughes RL: Comprehensive Stroke Certification. Western States Stroke, Albuquerque, NM September 2010
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Dysplasia. WSOC, Hyderabad, India. October 2016