University di Pisa, Pisa, Italy (Ed) Helminth Infections ...€¦ · Testing.- Renal Cell Culture.-...

18

Biomedicine springer.com/NEWSonline

A. Bal-Price, European Commission Joint Research Centre, Ispra, Italy; P. Jennings, Innsbruck Medical University, Innsbruck, Austria (Eds)

In Vitro Toxicology SystemsFeatures 7 Addresses toxicity testing, in vitro, in a variety of different human system simulations 7 Fea-tures difficult areas of toxicology such as carcino-genicity and nanotoxicology 7 Benefits students and experts in the field of chemical safety assess-ment as well as a wider scientific audience

Contents The Past, Present and Future of Chemical Risk Assessment.- In Vitro Systems for Hepatotoxic-ity Testing.- In Vitro Methods for Cardiotoxicity Testing.- Renal Cell Culture.- Cellular Models for In Vitro Lung Toxicology.- In Vitro Develop-mental Neurotoxicity Testing: Relevant Models and Endpoints.- Blood Brain Barrier In Vitro Models and Their Applications in Toxicology.- Ocular Toxicity.- In Vitro Models for Ototoxic Research.- Dermal Toxicity: Skin Sensitization.- Immunotoxicity.- Reproductive Toxicity.- Evaluat-ing Endocrine Disruption In Vitro.- Current and Emerging In Vitro Methods for Genotoxicity and Carcinogenicity.- Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening.- Human Stem/Progenitor Cell-Based Assays for Neurodevelop-mental Toxicity Testing.- High Content Imaging Approaches for In Vitro Toxicology.- Applica-tion of Omics Technologies to In Vitro Toxicol-ogy.- Stress Response Pathways.- Translational Biomarkers, In Vitro and In Vivo.- Nanotoxicol-ogy.- Consideration of Metabolism in In Vitro Cellular Systems.- In Vitro Approaches to Predic-tive Biokinetics.- Extrapolating In Vitro Results to Predict Human Toxicity.- Considerations in the Development of In Vitro Toxicity Testing Methods Intended for Regulatory Use.

Fields of interestPharmacology/Toxicology; Laboratory Medicine

Target groupsProfessional/practitioner

Product categoryContributed volume

Due May 2014

2014. XX, 980 p. 62 illus., 52 in color. (Methods in Pharmacology and Toxicology) Hardcover7 * € (D) 133,74 | € (A) 137,49 | sFr 166,507 € 124,99 | £112.50ISBN 978-1-4939-0520-1

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P. Boffetta, Mount Sinai School of Medicine Tisch Cancer Institute, New York, USA; S. Boccia, Institute of Hygiene Faculty of Medicine, Rome, Italy; C. La Vecchia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

A Quick Guide to Cancer EpidemiologyA Quick Guide to Cancer Epidemiology is an ideal addition to Springer Briefs in Cancer Re-search. The Brief provides core concepts in cancer epidemiology and also gives a snapshot of the epidemiology of seventeen human cancers. The Brief aims to provide-with quantitative focus-estimates of the global burden of neoplasms, of recent and likely future trends, distribution, causes and strategies for prevention for major groups of cancers. Finally, the Brief will give an overview of severals factors that cause cancer including dietary factors, tobacco smoking, obesity and alcohol consumption.

Features 7 Provides a quick snapshot of the epidemiol-ogy of seventeen cancers 7 Provides an overview of environmental factors that causes human can-cer 7 An ideal refresher for students, post docs and cancer epidemiologists

Contents Introduction.- Principles of primary and second-ary cancer prevention.- The global burden of neo-plasms.- Distribution, causes and prevention of individual neoplasms.- Overview of the causes of human cancer.- Conclusions.- References.- Index.

Fields of interestCancer Research; Medicine/Public Health, gen-eral; Biomedicine general

Target groupsResearch

Product categoryBrief

Due April 2014

2014. XIV, 100 p. 12 illus., 3 in color. (SpringerBriefs in Cancer Research) Softcover7 * € (D) 53,49 | € (A) 54,99 | sFr 67,007 € 49,99 | £44.99ISBN 978-3-319-05067-6

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F. Bruschi, University di Pisa, Pisa, Italy (Ed)

Helminth Infections and their Impact on Global Public HealthHelminths are long-lived multicellular organ-isms that have co-evolved with humans over many thousands of years. They are responsible for infections which affect around one third of the human population, at global level. Despite the huge efforts in research during the last years, effective control of helminth infections is still far from optimal standards and the resulting diseases remain neglected. This book aims to give an up-date overview to the epidemiology (including molecular typing), specific biological, immunolog-ical and immunopathological aspects, diagnosis and perspectives of control of the most common helminth infections.

Features 7 Gives a comprehensive overview to the top-ic 7 Refers to individual helminth infections and their specific aspects in biology, epidemiology and resulting health issues in humans 7 Highlights the importance of so far neglected infections

Contents Diversity and History as Drivers of Helminth Systematics and Biology.- Paleoparasitology of Helminths.- Schistosomiasis.- Fascioliasis.- Clo-norchiasis and Opisthorchiasis.- Echinococco-sis.- Taeniosis and Cysticercosis.- Trichinellosis.- Soil-transmitted helminthiasis.- Strongyloides stercoralis and Strongyloidosis.- Anisakiasis.- Lymphatic and Tissue Filariosis.- Dirofilaria Infections in Humans and Other Zoonotic Filari-oses.- Toxocarosis.- Angiostrongyloidosis.- Can the Study of Helminths be Fruitful for Human Diseases?.

Fields of interestParasitology; Medical Microbiology; Health Pro-motion and Disease Prevention



Due May 2014

2014. XII, 500 p. 43 illus., 31 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-3-7091-1781-1

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www.springer.com/978-1-4939-0520-1



19

News 3/2014 Biomedicine

D. Capco, Arizona State University, Tempe, AZ, USA; Y. Chen, Georgia Institute of Technology, Atlanta, GA, USA (Eds)

NanomaterialImpacts on Cell Biology and Medicine

The rapidly developing field of nanomaterials has expanded in many commercial areas.

Features 7 This book gives an intradisciplinary under-standing for neophytes as well as establishes investigators 7 Covers a broad field within nano-toxicology, medicine and biology studies 7 Inte-grates various fields of research 7 Each chapter has a Methodology section which explains how to conduct key technologies

Contents 1 Presence in, and release of, nanomaterials from consumer products.- 2 Nanoparticle ag-gregation.- 3 Influences of nanomaterials on the barrier function of epithelial cells.- 4 Engineered nanoparticles induced brush border disruption in a human model of the intestinal epithelium.- 5 Nanoparticles: Cellular uptake and cytotoxicity. -6 Atomic force microscopy study of the interaction of DNA and nanoparticles.- 7 Intracellular signal modulation by nanomaterials.- 8 Nanomaterials: Impacts on cells and cell organelles .- 9 Design, synthesis, and functionalization of nanoparticles for therapeutic drug delivery.- 10 Preparation of nanoscale pulmonary drug delivery formulations by spray drying.- 11 Nanomedicine: The Promise and Challenges in Cancer Chemotherapy.- 12 Transgenerational effects of NMs.- 13 Stem cells and nanomaterials.- Index.

Fields of interestBiomedicine general; Medicine/Public Health, general; Cell Biology



Due May 2014

2014. XV, 300 p. 69 illus., 41 in color. (Advances in Experimental Medicine and Biology, Volume 811) Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-94-017-8738-3

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R. Cingolani, Istituto Italiano di Tecnologia, Genoa, Italy (Ed)

Bioinspired Approaches for Human-Centric TechnologiesThe present book discusses topics related to research and development of materials and devices at nanoscale size and their respective application in medicine and biomedicine. The individual chapters give a detailed state of the art overview to the distinct topic. Apparently disconnected fields - life sciences, biomedicine, chemistry, physics, medicine and engineering - will be bridged with a highly interdisciplinary view onto each subject.

Features 7 Gives a condensed overview to the state of the art of nanotechnology and its applications in medicine 7 Written by dedicated experts in the respective fields 7 Creates links among appar-ently unrelated disciplines

Contents Nanotoxicology.- Smart materials for medical ap-plications.- Nanoparticles for drug delivery and diagnostics.- Brain-machine interfaces and arti-ficial robots for welfare and rehabilitation.- Single bioevent detection - New methods for early diagnostics.

Fields of interestPharmacology/Toxicology; Biomedicine general; Biomedical Engineering



Due May 2014

2014. X, 214 p. 113 illus., 97 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-319-04923-6

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A. Ebringer, King’s College London, London, UK (Ed)

Multiple Sclerosis, Mad Cow Disease and AcinetobacterThe aim of this book is to publicise and bring to a wider audience the concept that the cause of two neurological diseases, namely multiple sclero-sis (MS) and “mad cow disease” also known as “bovine spongiform encephalopathy” are related through exposure to a common microbe Aci-netobacter which is found in human sinuses, on skin and in the soil. An infection is the cause of a neurological disease in man and in animals.

Features 7 Discovery of the link between Acinetobacter bacteria in MS and BSE affected animals was made by the editor's team at KCL, who will discuss this discovery with a unique knowledge 7 The book will deal with the cause of MS throughout the world, which will arouse international interest in the scientific and medical community 7 Some 20 papers on neurological topics will be brought together, making this book accessible to patients, neurologists, research institutions, professionals and the general public

Contents 1. Scope and Features of the Disease MS in the World Population.- 2. History of the Attempts to Find the Cause of MS.- 3. “Experimental Allergic Encephalomyelitis” (EAE) as a Model of MS.- 4. The Problem of “Bovine Spongiform Encephalop-athy” or Mad Cow Disease.- 5. The Link Between EAE and BSE.- 6. Molecular Sequences in EAE and BSE Point to Acinetobacter Bacteria.- 7. Antibodies to Acinetobacter in BSE Animals.- 8. Antibodies to Acinetobacter in MS Patients.- 9. The use of “Popper Sequences” to investigate AS.- 10. Therapeutic implications and General Conclusions.

Fields of interestAntibodies; Immunology; Infectious Diseases


Product categoryHandbook

Due November 2014

2015. X, 250 p. 24 illus., 4 in color. Hardcover7 approx. * € (D) 149,79 | € (A) 153,99 | sFr 186,507 approx. € 139,99 | £126.00ISBN 978-3-319-02734-0

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20


T. Furukawa, S. Kawamura, Osaka University, Suita, Japan; J. B. Hurley, University of Washington, Seattle, WA, USA (Eds)

Vertebrate PhotoreceptorsFunctional Molecular Bases

This book provides a series of comprehensive views on various important aspects of vertebrate photoreceptors. The vertebrate retina is a tissue that provides unique experimental advantages to neuroscientists. Photoreceptor neurons are abun-dant in this tissue and they are readily identifiable and easily isolated.

Features 7 Integrates recent genetic, biochemical and physiological advances in the understanding of vertebrate photoreceptors 7 Highlights recent advances in understanding a neuronal system that is used widely as a model for many types of sensory transduction 7 Highlights the types of experimental approaches that have been most successfully used to advance the understanding of sensory systems

Contents Chapter 1 Visual Pigments.-Chapter 2 Phototransduction.-Chapter 3 Visual Cycle.-Chap-ter 4 Adapatation.-Chapter 5 Energy Metabolism.-Chapter 6 Photoreceptor Development.-Chapter 7 Photoreceptor Synapse -- Synaptic Transmission.-Chapter 8 Photoreceptor Synapse -- Development of Synapse.-Chapter 9 Cell fate Determination.-Chapter 10 Polarity and Layer Formation.-Chapter 11 Photoreceptor Degeneration.- Chapter 12 Photoreceptor Regeneration.- Chapter 13 Pineal Organs.

Fields of interestNeurosciences; Cell Biology; Evolutionary Biology



Due May 2014

2014. XV, 430 p. 65 illus., 20 in color. Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-4-431-54879-9

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E. Grande, Hospital Ramon y Cajal, Madrid, Spain; L. Antón-Aparicio, A Coruña University Hospital Complex, A Coruña, Spain (Eds)

Stem Cells in Cancer: Should We Believe or Not?This volume explores the latest developments in a novel area of molecular biology and a hot topic in the field of oncology: cancer stem cells. These chapters from expert contributing authors present concepts such as the universal stem cell, new molecular pathways, new targeted agents, the different roles that cancer stem cells seem to have according to the organ they are placed in, and the future role that targeting cancer stem cells may have in the management of patients in the clinic.

Features 7 Updates the field on stem cells in cancer, pro-viding information on new molecular pathways with new targeted agents currently under investi-gation 7 Reviews current research in this field of stem cells applied to patients with cancer 7 Pres-ents possible potential future treatment modalities for the management of advanced cancer patients

Contents Foreword.- The universal stem cell: does it exist?.- What is the meaning of Notch pathway and how we can selectively do the targeting.- Hedhehog as a new paradigm in cancer treatment Stem cells in cancer: should we believe or not?.- Wnt pathway at a glance: from the deep of the crypts to the current ways of targeting.- Cancer Stem Cells in Brest Cancer.- Cancer Stem Cells in Colon Cancer.- Cancer Stem Cells in Genitourinary Cancer.- Can-cer Stem Cells in Pancreatic Cancer.- Cancer Stem Cells in Gastric Cancer.- Cancer Stem Cells in Melanoma.- Cancer Stem Cells in Brain Tumors.- Cancer Stem Cells in Sarcomas.- Cancer Stem Cells in Gynecologic Tumors.

Fields of interestCancer Research; Stem Cells; Oncology



Due April 2014

2014. CCCXXV, 12 p. 23 illus., 19 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-94-017-8753-6

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P. Hellman, MD, Ph.D, University Hospital, Uppsala, Sweden (Ed)

Primary AldosteronismMolecular Genetics, Endocrinology, and Translational Medicine

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA.

Features 7 Presents Primary Aldosteronism (PA) from pathophysiology to quality of life aspects, covering genetics, diagnostics, different treatments in a truly translational manner 7 Discusses what is needed for the development of care of individu-als with PA 7 Explores recent developments in understanding the genetics behind sporadic PA that may lead to novel methods to diagnose the disease in the future

Contents Introduction.- Primary Aldosteronism: Molecular Mechanisms and Diagnosis.- Epidemiology and need for screening.- Low renin hypertension.- Molecular derangements in sporadic primary aldosteronism.- From genetic abnormalities to pathophysiological mechanisms.- Familial hyperaldosteronism type I.- Familial hyperaldo-steronism type II.- Familial hyperaldosteronism type III.- The Aldosterone-renin ratio – role and problems.- Confirmatory testing for Primary Aldosteronism.- Radiological imaging of adre-nocortical tumors.- Aldosterone and cardiovas-cular disease.- Quality of life aspects of primary aldosteronism.- Medical treatment of primary aldosteronism.- Surgical treatment of primary aldosteronism.- Index.

Fields of interestHuman Genetics; Endocrinology; Biomedicine general



Due April 2014

2014. VIII, 316 p. 25 illus., 17 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-1-4939-0508-9

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21


JIMD ReportsG. Brown, E. Morava (Eds), K. M. Gibson, Editor-in-chief: J. Zschocke, Managing editor: V. Peters

Volume 13

J. Zschocke, Medical University Innsbruck, Innsbruck, Austria; K. M. Gibson, Michigan Technological University, Houghton, MI, USA; G. Brown, University of Oxford, Oxford, UK; E. Morava, Tulane University Medical Center, New Orleans, LA, USA; V. Peters, Center for Child and Adolescent Medicine Heidelberg University Hospital, Heidelberg, Germany (Eds)

JIMD Reports - Case and Research Reports, Volume 13JIMD Reports publishes case and short re-search reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Features 7 Unique collection of case and research reports on rare metabolic disorders 7 Contains unusual or previously unrecorded features relevant to metabolic disorders 7 All contributions rigor-ously peer-reviewed

Fields of interestHuman Genetics; Metabolic Diseases; Pediatrics



Due April 2014

2014. X, 140 p. Softcover7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-3-642-54148-3

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E. S. Kleinerman, M.D Anderson Cancer Center Division of Pediatrics, Houston, TX, USA (Ed)

Current Advances in OsteosarcomaContents Chromothripsis-A new mechanism for genomic instability and its role in OS- (AM Flanagan and MR Stratton (UCL Cancer Institute).-Role of Au-tophagy in OS- Nancy Gordon (MD Anderson).-HER-2 Involvement in OS - Rich Gorlick (Albert Einstein College of Medicine) .-Conditionally replicative Adenovirus Ad5-delta 24RGD for OS Lung Metastasis - Harm CA Graat (VU University Medican Center) .- WNT Signaling in OS - Bang Hoang (University of California, Irvine) .- Ze-brafish Model of OS - Pancras CW Hogendoorn (Leiden University Medical Center) .-History of Chemotherapy in Treatment of OS -Norman Jaffe (MD Anderson) .-Genetic and Clinical Features of OS in Micro-RNA Profiles -Kevin B Jones (Huntsman Institute).-Role of Lung Microen-vironment in Metastatic Potential of OS Cells -Eugenie S Kleinerman (MD Anderson) .-Role of Ezrin in OS Metastasis -Chand Khanna (National Cancer Institute) .-Oncolytic Viruses for Poten-tial OS Therapy-E Anders Kolb (Alfred Dupont Hospital for Children) .-Use of Natural Killer T Cells for OS -Dean Lee (MD Anderson) .-MTAP Inhibitors -John A Martignetti (Mt Sinai School of Medicine) .-Molecular Pathogenesis of OS - Kurth Weiss (University of Pittsburgh)

Fields of interestCancer Research; Medical Microbiology; Cell Biology



Due June 2014

2014. X, 310 p. 40 illus. in color. (Advances in Experimental Medicine and Biology, Volume 804) Hardcover7 approx. * € (D) 149,79 | € (A) 153,99 | sFr 186,507 approx. € 139,99 | £126.50ISBN 978-3-319-04842-0

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E. Kulchavenya, Research TB Institute, Novosibirsk, Russia; D. Kholtobin, Novosibirsk TB Research Institute, Novosibirsk, Russia

Urogenital Tuberculosis: Epidemiology, Diagnosis, TherapyThis book approaches the classification, pathogen-esis, diagnostic, therapy and surgery for kidney tuberculosis as well as male genital tuberculosis. The reader will find recent data on epidemiology, many interesting history cases with illustrations and new methods for the identification of Myco-bacterium tuberculosis.

Features 7 Covers all forms of urological tuberculosis with specification on separate forms 7 Written by the specialist in this field and author of many patents on methods for diagnosis and therapy for urogeni-tal tuberculosis 7 Outlines unique approaches to the management of Urogenital Tuberculosis patients

Contents Introduction.- Epidemiology of Urogenital Tuber-culosis as a part of Extrapulmonary Tuberculosis.- Classification of Urogenital Tuberculosis.- Clinical features of Urogenital Tuberculosis.- Diagnostic of Urogenital Tuberculosis.- Predisposition, Patho-genesis and Prophylaxis.- Bladder tuberculosis.- Male genital tuberculosis.- Therapy of Urogenital Tuberculosis.- Surgery of Urogenital Tuberculo-sis.- Acknowledgments.- References.

Fields of interestMedical Microbiology; Human Physiology; Urol-ogy/Andrology


Product categoryMonograph

Due March 2014

2014. XIV, 133 p. 39 illus., 32 in color. Hardcover7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-3-319-04836-9

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22


E. Lammert, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; M. Zeeb, Boehringer Ingelheim Pharma, Biberach, Germany (Eds)

Metabolism of Human DiseasesOrgan Physiology and Pathophysiology

Contents Introduction.- Brain: Overview.- Major depres-sive disorder.- Schizophrenia.- Epilepsy.- Par-kinson’s disease.- Alzheimer’s disease.- Migraine and cluster headache.- Multiple sclerosis.- Down syndrome.- Eye: Overview.- Age-related macu-lar degeneration.- Glaucoma.- Teeth and bones: Overview: Dental caries.- Osteoporosis.- Joints: Overview.- Osteoarthritis.- Rheumatoid arthri-tis.- Gastrointestinal tract: Overview.- Peptic ulcer disease.- Gastroenteritis.- Lactose intolerance.- Colorectal cancer.- Pancreas: Overview.- Diabetes mellitus.- Liver: Overview.- Cirrhosis.- Fat tissue: Overview.- Metabolic syndrome.- Lung: Over-view.- Asthma.- COPD.- Community-acquired pneumonia.- Heart: Overview.- Atherosclerotic heart disease.- Heart failure.- Blood vessels: Over-view.- Stroke.- Varicose Veins.- Blood: Overview.- Sickle Cell Disease.- Hyperlipidemia.- Immune system: Overview.- Fever.- Sepsis.- Allergies.- Kid-ney: Overview.- Hypertension.- Chronic kidney disease.- Gout and hyperuricemia.- Urinary tract infections.- Kidney stones.- Reproductive system: Overview.- Breast cancer.- Prostate cancer.- Can-cer: Overview.

Fields of interestHuman Physiology; Metabolic Diseases; Biochem-istry, general

Target groupsGraduate


Due April 2014

2014. XXIV, 445 p. 108 illus., 21 in color. Softcover7 * € (D) 149,75 | € (A) 153,94 | sFr 201,007 € 139,95 | £126.00ISBN 978-3-7091-0714-0

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P. S. Leung, School of Biomedical Sciences, Hong Kong, People’s Republic of China (Ed)

The Gastrointestinal SystemGastrointestinal, Nutritional and Hepatobiliary Physiology

Gastrointestinal (GI) physiology is a funda-mental subject that is indispensable not only for undergraduate but also for graduate courses. The audience include, but are not limited to, medi-cal, pharmacy, nursing, human biology, Chinese medicine, and science students, as well as other health-related subject students. The overall objec-tives of this textbook are to present basic concepts and principles of GI physiology and, more impor-tantly, to convey an understanding of how to apply this knowledge to abnormal GI physiology in the clinical context.

Features 7 Comprehensive yet concise concepts of GI physiology 7 A wide range of scenario-based clinical case studies 7 Multiple choice questions for review examination

Contents Regulation of Gastrointestinal Functions.- Gastro-intestinal Motility.- Gastric Physiology.- Exocrine Pancreatic Physiology.- Intestinal Water and Electrolyte Transport.- Digestion and Absorption of Carbohydrates and Proteins.- Digestion and Absorption of Dietary Triglycerides.- Digestion and Absorption of Other Dietary Lipids.- Ab-sorption of Water Soluble Vitamins and Miner-als.- Structure, Functional Assessment and Blood Flow.- Protein Synthesis and Nutrient Metabo-lism.- Biotransformation, Elimination and Bile Acid Metabolism.

Fields of interestHuman Physiology; Gastroenterology

Target groupsUpper undergraduate

Product categoryGraduate/Advanced undergraduate textbook

Due May 2014

2014. III, 342 p. 161 illus., 109 in color. Hardcover7 * € (D) 74,89 | € (A) 76,99 | sFr 93,507 € 69,99 | £62.99ISBN 978-94-017-8770-3

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A. Masoudi-Nejad, University of Tehran Institute of Biochemistry and Biophysics, Tehran, Iran; A. Meshkin, University of Tehran, Tehran, Iran

Gene PrioritizationRationale, Methodologies and Algorithms

Identifying causal genes underlying susceptibil-ity to human disease is a problem of primary importance in the post-genomic era and in cur-rent biomedical research. Recently, there has been a paradigm shift of such gene-discovery efforts from rare, monogenic conditions to common “oligogenic” or “multifactorial” conditions such as asthma, diabetes, cancers and neurological disorders. These conditions are referred to as multifactorial because, susceptibility to these diseases is attributed to the combinatorial effects of genetic variation at a number of different genes and their interaction with relevant environmental exposures. The goal of this book is to introduce gene prioritization aspects and the candidate gene prioritization algorithms to give readers a compre-hensive view on the subject.

Features 7 Introduces gene prioritization aspects and candidate gene prioritization algorithms to give readers a comprehensive view on the sub-ject 7 Focuses on gene prioritizations concepts and gene prioritization algorithms 7 Useful to both biologists and computer scientists to get an idea about the field and serves as a strong starting point for someone who wants to work on gene prioritization methods

Contents Gene Prioritization Concepts.- Gene Prioritiza-tion Rationale.- Evaluations Methods for Gene Prioritization.- Gene Prioritization algorithms.- Successes.- Non-networked-based apoproaches.- Network-based approaches.- Conclusions.

Fields of interestHuman Genetics; Gene Function; Bioinformatics



Due February 2014

2014. I, 120 p. 29 illus., 21 in color. (SpringerBriefs in Systems Biology) Softcover7 * € (D) 53,49 | € (A) 54,99 | sFr 67,007 € 49,99 | £44.99ISBN 978-3-319-04686-0

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23


B. Nilius, KU Leuven Department Cell Mol Medicin, Leuven, Belgium; V. Flockerzi, Universität des Saarlandes, Homburg, Germany (Eds)

Mammalian Transient Receptor Potential (TRP) Cation ChannelsVolume I

In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and phar-macology of mammalian TRP channels.

Features 7 Gives an excellent overview on mamma-lian TRP cation channels, a rapidly moving field 7 Written by outstanding authorities in the field 7 With numerous illustrations

Contents TRP Channels: An Introduction.- TRP Channels: Evolutionary Aspects.- The TRCP Subfamily.- The TRPV Subfamily.- The TRPM Subfamily.- The TRPML Subfamily.- The Polycystin Subfam-ily.- TRPs as Special Cell Sensors.- TRPs in Mechano-sensing and Volume Regulation. TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmit-ters).- Photo Sensing and Photosensitive TRPs in Mammals.- TRPs in Tase and Chemesthesis.- Pain.- TRPs in Hearing.- TRPs in Olfaction.- TRP Structure.- TRP Heteromers.- The TRP-STIM-ORAI Interaction.- Role of TRPC Channels Deduced From the Corresponding Knock-Out Mice.- TRPs as Novel Drug Targets.- TRPs in En-docrinology.- TRPs Modulation by Toxins.- TRPs and Phosphoinositides.- TRPs Modulation by Natural Compounds.- What do we Really Know and What do we Need to Know: Controversies, Perspectives, Surprises.

Fields of interestPharmacology/Toxicology; Human Physiology; Molecular Medicine


Product categoryHandbook

Due October 2014

2014. XII, 715 p. 56 illus., 39 in color. (Handbook of Experimental Pharmacology, Volume 222) Hardcover7 * € (D) 394,83 | € (A) 405,90 | sFr 491,507 € 369,00 | £332.50ISBN 978-3-642-54214-5

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Progress in Drug ResearchK. D. Rainsford (Ed)

Volume 68

O. M. Abdel-Salam, National Research Center, Cairo, Egypt (Ed)

Capsaicin as a Therapeutic MoleculeFeatures 7 Compiles the available knowledge on the vari-ous therapeutic applications of capsaicin 7 Cov-ers basic issues of the capsaicin receptor, its mechanisms of action and its role in physiological and pathological processes 7 Of interest to both researchers and clinicians

Contents Capsaicin and Sensory Neurones: a Historical Perspective.- Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanil-loid Type 1 Ion Channel.- TRPV1 in the Central Nervous System: Synaptic Plasticity, Function and Pharmacological Implications.- Topical Capsaicin Formulations in the Management of Neuro-pathic Pain.- Capsaicin-Based Therapies for Pain Control.- Intranasal Capsaicin in Management of Non-allergic (Vasomotor) Rhinitis.- Capsaicin as an Anti-obesity Drug.- The Potential Antitumour Effects of Capsaicin.- Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination with Non-Steroidal Anti-inflammatory Drugs in Human Healthy Subjects and in Patients.- Calcitonin Gene-Related Peptide as Target of Capsaicin Receptor in the Gut.- Capsaicin for Osteoarthritis Pain.- The Role of Capsaicin in Dermatology.- Use of Vanilloids in Urologic Disorders.

Fields of interestPharmacology/Toxicology; Pain Medicine; Oncol-ogy



Due May 2014

2014. VII, 416 p. 37 illus., 25 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-0348-0827-9

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Reviews of Physiology, Biochemistry and PharmacologyB. Nilius, R. Lill, O. H. Petersen, R. Jahn, S. Offermanns, Series editor: T. Gudermann

Volume 166

B. Nilius, KU Leuven Dept. of Cell. and Molecular Medici, Leuven, Belgium; T. Gudermann, München, Germany; R. Jahn, Max-Planck-Institute for Biophysical, Göttingen, Germany; R. Lill, Universität Marburg Inst. Zytobiologie und, Marburg, Germany; S. Offermanns, Max-Planck-Inst. für Herz u. Lungen, Bad Nauheim, Germany; O. H. Petersen, Cardiff University School of Biosciences, Cardiff, UK (Eds)

Reviews of Physiology, Biochemistry and Pharmacology, Vol. 166Contents TRP channels coordinate ion signalling in astro-glia by Alexej Verkhratsky, Reno C. Reyes, and Vladimir Parpura.- Pharmacological inhibition of actin assembly to target tumor cell motility by Alexander Nürnberg, Alina Kollmannsperger, and Robert Grosse.- The role of mTORC1 in regulat-ing protein synthesis and skeletal muscle mass in response to various mechanical stimuli by Craig A. Goodman.

Fields of interestHuman Physiology; Pharmacology/Toxicology; Cancer Research



Due May 2014

2014. X, 100 p. 7 illus., 2 in color. Hardcover7 approx. * € (D) 106,99 | € (A) 109,99 | sFr 133,507 approx. € 99,99 | £90.00ISBN 978-3-319-04905-2

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24


S. Shiozawa, Kyushu University Beppu Hospital, Beppu, Japan (Ed)

Arthritis ResearchMethods and Protocols

Contents Intravital Multiphoton Microscopy for Dissect-ing Cellular Dynamics in Arthritic Inflammation and Bone Destruction.- Monitoring Multifunc-tionality of Immune-Exhausted CD8 T in Cancer Patients.- Characterization of Innate Immune Signalings Stimulated by Ligands for Pattern Recognition Receptors.- Principled for the Use of in vivo Transgene Techniques: Overview and an Introductory Practical Guide for the Selection of Tetracycline-Controlled Transgenic Mice.- Unrav-eling Autoimmunity with the Adoptive Transfer of T Cells from TCR-Transgenic Mice.- In Vivo Cell Transfer Assay to Detect Autoreactive T Cell Sub-sets.- Characterization of microRNAs and Their Targets.- Studies on the T Cell Receptor (TCR) Re-vision of Autoantibody-Inducing CD4T (aiCD4 T) Cell.- Basic Techniques for Studies of iNKT Cells and MAIT Cells.- Induction of de novo Autoim-mune Disease in Normal Mice Upon Repeated Immunization with Antigen.- Mouse Models of Experimental Dermal Fibrosis: The Bleomycin-Induced Dermal Fibrosis.- Screening for Novel Serum Biomarker for Monitoring Disease Activity in Rheumatoid Arthritis Using iTRAQ Technol-ogy Based Quantitative Proteomic Approach.- Genome-Wide Genetic Study in Autoimmune Disease Prone Mice.- Bayesian Systems-Based Genetic Association Analysis with Effect Strength Estimation and Omic Wide Interpretation: A Case Study in Rheumatoid Arthritis.- Sample Processing, Protocol and Statistical Analysis of the Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) of Protein, Cell and Tissue Samples.- Label-Free Imaging of Adipogenesis by Coherent Anti-Stokes Raman Scattering Microscopy.

Fields of interestMolecular Medicine; Orthopedics; Rheumatology



Due April 2014

2nd ed. 2014. XIV, 238 p. 54 illus., 31 in color. (Methods in Molecular Biology, Volume 1142) Hardcover7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-4939-0403-7

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P. Wang, The Feinstein Inst. for Medical Research Surgery, Manhasset, NY, USA (Ed)

MFG-E8 and InflammationAfter the discovery of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) about two decades ago, a new era of delineating its potential beneficial role in several inflammatory diseases has begun to spout from the bench to translational research. In MFG-E8 and Inflammation, the editor and contributors have gathered a remark-able collection covering novel discoveries on the rapidly growing field of MFG-E8 and Inflamma-tion which includes not only the findings from their individual lobotomies, but also from a host of pioneering researchers of this field.

Features 7 Simple and easy illustration of the complex network of innate immune system in human diseases 7 A number of novel mechanistic aspects highlighting MFG-E8's therapeutic poten-tial 7 Includes several animal models relevant to critical care medicine and inflammatory diseases

Contents Preface.- MFG-E8: origin, structure, expression, functions and regulation.- MFG-E8 as a marker for apoptotic, stressed and activated cells.- Role of MFG-E8 in protection of intestinal epithe-lial barrier function and attenuation of intesti-nal inflammation.- MFG-E8 in the blood cell homeostasis and coagulation.- MFG-E8 in the vascular system.- Autoimmune diseases and the role of MFG-E8.- Novel therapeutic for systemic inflammation: role of MFG-E8.- Expression and function of MFG-E8 during intestinal inflamma-tion.- MFG-E8 and acute lung injury.- Role of MFG-E8 in the brain. Index.

Fields of interestCancer Research; Immunology; Cell Biology



Due April 2014

2014. XV, 210 p. 29 illus., 20 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-94-017-8764-2

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W. Wei, H. Inuzuka, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA

SCF and APC E3 Ubiquitin Ligases in TumorigenesisThis SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer de-velopment. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression.

Features 7 Includes updated profiles of SCF and APC cel-lular functions and their characterized ubiquitin substrates 7 Introduces the emergent SCF family members in the human genome and summarizes phenotypes in which the adapter proteins of SCF and APC are manipulated to reflect the pathogen-esis of human cancer 7 Discusses how SCF and APC may represent promising therapeutic targets to treat various types of cancers

Contents 1. Introduction.- 2. The Fbxw subclass of SCF E3 ubiquitin Ligases.- 3. The FbxL subclass of SCF E3 ubiquitin Ligases.- 4. The Fbxo subclass of SCF E3 ubiquitin Ligases.- 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases.- 6. Conclusions and Future Perspectives.

Fields of interestCancer Research; Cell Cycle Analysis; Protein Structure



Due March 2014

2014. VIII, 136 p. 11 illus. in color. (SpringerBriefs in Cancer Research) Softcover7 * € (D) 53,49 | € (A) 54,99 | sFr 67,007 € 49,99 | £44.99ISBN 978-3-319-05025-6

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