Unit 6 Early Research
-
Upload
smallbrowndog -
Category
Documents
-
view
220 -
download
0
Transcript of Unit 6 Early Research
-
8/2/2019 Unit 6 Early Research
1/14
Unit6-Commission
EARLY RESEARCH
-
8/2/2019 Unit 6 Early Research
2/14
ResearchKeythingstoworkout
1)TheSciencebehindTelomeres
2)Thetargetgroup
3)Howtoconnectthesciencetothetargetgroup
-
8/2/2019 Unit 6 Early Research
3/14
1theScience
IleEschool20yearsago.IvaguelyremembermakingaDNAhelixoutofstraws.ButthescienceisbeyondmeandIcantfindanytelomeresfordummiesbooks,soIhaveharanguedascience-teacherfriendintoexplainingitall.Thishas
beenahugehelp.
Humansaremadeofmillionsofcells.Thishas
anumberofbenefits:
Cellscanbespecialisedtodoparculartasks
groupsofcellscanfunconasorgansmakingamoreefficientbutcomplex
organism
theorganismcangrowverylarge
Cells
-
8/2/2019 Unit 6 Early Research
4/14
Newcellsareneededthroughoutlife.Theseare
forgrowth,toreplacedamagedcellsandrepair
wornoutssues.Normalhumanbodycellsare
diploidtheyhavetwoofeachchromosome.
Whennewcellsaremade,these46
chromosomes(inotherorganismsthenumber
isdifferent)arecopiedexactlyinaprocess
calledmitosis.
Mitosisisthetypeofcelldivisionusedfor
growthandrepair.Mitosisoccurswherevernew
cellsareneeded.Itproducestwocellsthatare
idencaltoeachother,andtheparentcell.Inmitosiseachchromosomeiscopiedexactly.
Thenewchromosomesaremovedtoopposite
sidesofthecell,beforethecelldividesleaving
onecompletesetof46chromosomesineachof
thetwonewcells.
Celldivision
-
8/2/2019 Unit 6 Early Research
5/14
WhatareTelomeres?
Whataretelomeres?
RepeatedDNAthatformsprotecvecapsattheendsofourchromosomes.
Telomeresperformasimilarroletotheplascpattheendofashoelace.Liketheseplasc
psthatkeepshoelacesfrombecomingdamagedorfrayed,telomeresprotectourchromosomesfromthecricalshorteninganddamagethatmayulmatelyleadtocellulardeathandlossofhealth.Telomeresshortenoverme,andthisshorteningisconsideredbothamarkerofcellagingaclockofthe
cell'slifespanaswellasacausalfactorincellaging.Telomereshorteningislikea"genecmeclock"indicangareducedcellularlifespan.Whentelomeresreachcricallyshortlengths,theclock"runsoutofme,"andcellsceasetofunconnormallyandcandiealtogether.
-
8/2/2019 Unit 6 Early Research
6/14
Howaretelomeresdifferentfromtherestofour
DNA?
TelomeresconsistofaspecialDNAsequenceandspecializedtelomericproteinsthattogetherformaprotecvecaponourchromosomes.Unlikeanyotherpartofthegenome,theyare
consideredabiologicalmarkeroftheaccumulatedwearandtearofliving,integranggenecinfluences,lifestylebehaviorsandstress.Mostimportantlytelomeresaretheonlyknownpartof
ourgenecsequencethataredynamic,andtheyappeartobeinfluencedbynon-genecfactorssuchaslifestylechanges(diet,behavior,andmentalwellbeing).
-
8/2/2019 Unit 6 Early Research
7/14
Howaretelomeresrelatedtolifeandaging?
Telomereshorteningisinmatelyinvolvedinhumandiseaseandmortality.Shorttelomeresimpairtheabilityofcellstodivideproperly.WhentheDNAinacellisunabletoproperlyreplicate,thecelleitherundergoescelldeath,orpotenallyworse,connuestostayalivebutfunconspoorly.Poorlyfunconingcellscanaltera
healthyphysiologicalbalanceinthebody,by,forexample,creangahighlevelofpro-inflammatorycytokinesintheblood.
Studieshaveshownassociaonsbetweenshortertelomerelengthandvarioustypesofcardiovasculardisease(e.g.,stroke,heartaacks),cancer,anddiabetes.Shortertelomereshavealsobeenassociatedwithosteoporosis,cognivefuncon,demena,depression,andinflammatorydiseaseslikearthris.Conversely,longertelomeresarelinkedtohealthyagingandoveralllongevity.
-
8/2/2019 Unit 6 Early Research
8/14
Targetgroup
Childrenandyoungpeopledontwanttoknowaboutaging.
Olderpeopledontnecessarilywanttoknowaboutaging,butareinterestedinhowtohold
theprocessoff
Itisnotrelevantfortheveryelderly Mytargetgroupis50+-theysllhavemetochangetheirhabits!
-
8/2/2019 Unit 6 Early Research
9/14
PresenngInformaonforthetargetgroup
ItisreasonabletoassumethatcompaniessuchasSagahavedoneextensivemarketresearchintothistargetgroup.
-
8/2/2019 Unit 6 Early Research
10/14
However,aquicksurveyofpeopleaged50+revealedthat,
whiletheyareclearandeasytofollow,theseweb-pages
aimedat50+areflatanduninspiring.
-
8/2/2019 Unit 6 Early Research
11/14
Theseexampleshavetoomuchinformaontobeclear
-
8/2/2019 Unit 6 Early Research
12/14
Theseareclear,bright
butnotoverpowering,
andfun!
-
8/2/2019 Unit 6 Early Research
13/14
Andthefavourite
-
8/2/2019 Unit 6 Early Research
14/14
Whatpartoftheinformaondotheyneed/wantto
know?
Frommyselectgroupofover50s:
Whatishappening,inlay-mansterms-minimalscience Howitimpactsonmenow Isittoolatetobotherworryingaboutit?