Understanding Clinical Aspects: A must for creating a ... · Content shared with grateful...
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Understanding Clinical Aspects:
A must for creating a successful Bioenterprise
Dr. Avijit Bansal Co-founder and CEO,
Windmill Health Technologies
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Are we creating enough
perceivable value for enough
number of people for them to
pay sufficiently to enable us to
continue delivering that value
sustainably, scalably and
profitably.
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Disease state analysis
Disease state
1
• Why analyze disease states?
• What to consider while analyzing disease states?
• How to analyze disease states?
Learning Objectives
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Why study disease states?
Med-tech innovation is essentially the process of seeking to address
GAPS in the TREATMENT OPTIONS for DISEASE STATES
Disease state
Treatment options
GAP
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Why study disease states?
• To find out potential strategies and points for intervention in the disease causation cycle • To choose among different intervention strategies • To be able to understand scientific evidence and communicate more effectively with domain experts • To be able to ask the right questions
It is imperative to understand the causes, mechanisms, effects and risks associated with diseases
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•To be exposed to the entire gamut of felt needs associated with the disease •To be able to uncover needs hitherto not identified and addressed •To avoid taking a path – that is soon going to be outdated, due to an upcoming drug/ procedure/ innovation • To further validate a need
Instinct to jump ahead and start inventing may lead to misplaced, unsuccessful solutions and much agony later.
Why study disease states?
It is imperative to understand the causes, mechanisms, effects and risks associated with diseases:
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Hitchhiker’s guide to jargon in the medical galaxy
With inputs from: Biodesign: The Process of Innovating Medical Technologies, Cambridge University Press
Focus Area Description
Anatomy Study of normal structure and organization of the human body
Physiology Study of Normal functioning of the human body
Pathophysiology Describes the disturbance of normal anatomy and physiology caused by disease or other underlying physical, mechanical, electrical, or biochemical abnormality
Clinical Presentation
What the disease leads to Symptoms- what patient perceives and suffers from (Eg: Pain) Signs – What the doctor elicits upon examination (Eg. Tenderness )
Clinical outcomes Profiles most common results of a given disease. Eg: Death, Disability, Hospital admission, Complete Cure
Epidemiology Describes causes, distribution, and control of disease in the population
Economic impact Outlines cost of disease to the patient, family, health care system and the society at large
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Before you begin..
• First understand the body’s NORMAL STRUCTURE and FUNCTION (known as ANATOMY and PHYSIOLOGY) • Questions you may want to ask: Which system is affected? What does it do? How does it normally work? Which organ is affected? What does it do? How does it normally work? Which other organs/ systems could this affect? What is their working?
Before you can deal with the abnormal, need to understand what is normal!
• Visual understanding is important- position, size and proximity of affected organs/systems
• May need to have a gross (macroscopic) as well as microscopic understanding
• Explore physiological, biochemical, mechanical and electrical mechanisms
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Questions to ask about disease state
is the disease? What
Begin by trying to summarize to yourself in one line (or a few lines): •What organ/ organ system is affected? • What is wrong with the affected system? • What is the immediate impact of the disease on the body? • What is the long term/ overall impact?
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Questions to ask about disease state
is the disease? What
Examples: •Cataract is a disorder of the of the lens in the eye leading to loss of vision •Diabetes affects beta cells in the pancreas, leading to decreased insulin secretion, leading to elevated glucose levels in the body – which puts most other body systems at risk. While short term symptoms include excessive hunger, thirst, urination – in the long term it could cause loss of vision, kidney failure, non-healing ulcers, stroke etc •Inguinal Hernia is a protrusion of an abdominal organ, mostly intestines through an abnormal opening into the scrotal sacs. While in the short term it causes discomfort, it may also get “caught” or strangulated leading to sudden life threatening situation
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Questions to ask about disease state
is affected? (Epidemiology) Who
• Age group • Gender • Socio-economic status • Geographic distribution
• Within the country • Globally
• Ethnic prediliction
All these factors have an important bearing on potential market size, choice of approach to solution, associated risk profile etc
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Important terms in epidemiology
• Incidence - number of new cases diagnosed per year
• Prevalence – Total number of people afflicted with a disease at a given point of time
• Epidemiology data serves as background information for market analysis
• Include data for disease as a whole, most prevalent patient sub-segments, and disease dynamics- growth rate
Incidence
Prevalence
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Questions to ask about disease state
What causes the disease?
The term cause is used where there is a single definite cause Eg. The bacterium called MTB (Mycobacterium Tuberculosis) causes tuberculosis The term risk factor is used when multiple factors are associated with causing a disease. Eg. Heridity, Obesity, Sedentary lifestyle, stress are all associated with T2 Diabetes
Example 1: Knowing that default in treatment is the biggest cause for drug resistant tuberculosis will bring treatment compliance enhancing devices into the horizon of solutions for therapy of Tuberculosis – something that may not occur otherwise Example 2: When trying to innovate a device solution for diabetes patients: Understanding that obesity is a risk factor / cause for uncontrolled diabetes will bring obesity reduction devices into the horizon of potential solutions
(Aetiology)
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How is the disease caused?
• This is the most important aspect, since it lays the foundation for potential management strategies Example 1: Ardian Example 2: Emphasys
(Pathogenesis or mechanisms)
Questions to ask about disease state
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Excessive fat intake
Excessive absorption
High cholesterol
in blood
Cholesterol deposits and blockade in
heart’s circulation
Ischemia (Angina and heart attack)
Stenting Drug therapy Bypass Surgery Ballooning
Ischemia (Angina and heart attack)
Understanding the pathogenesis broadens innovative possibilities
Conventional choice of management of Ischemic heart disease
Gastric pacemaker
(prevents patient from
eating too much)
Innovative approach to the same : Includes prevention
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Questions to ask about disease state
What is the impact of the disease?
• Knowing the symptoms is essential to understanding the biggest PAIN-POINTS for the patients, caregivers and other stakeholders
• This is key to innovating a
solution that patients (and other stakeholders) will be keen to adopt
• All 4 factors are important
(Symptoms, sequelae and outcomes)
What do they
SAY
What is the disease making them
FEEL
What is the disease making them
THINK
What is the disease
making them
DO
Patients need …
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Questions to ask about disease state
Two important points to consider while assessing impact : Morbidity and Mortality
• Quantitative measures of mortality: • Acute diseases: Case fatality rate, number of deaths • Chronic diseases:
• Reduction in life expectancy • Increased risk of death
• Quantitative measures of morbidity: • Acute diseases : Rate of hospitalization, sick leaves, avg length of hospital stay • Chronic Diseases
• Quality of life score (QOL) • Disease specific indicators eg: SGRQ for QOL in COPD patients • Disability Adjusted Life Years lost (DALYs) • Quality adjusted Life years lost (QUALYs) • Visual analogue scale (for severity of pain)
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Points to consider while analyzing impact :
• Physical • Pain • Disability • Activities of daily living • Impact on Routine
• Social and emotional impact
* In a survey of single upper limb amputees, it was found that their most imporant need was “to appear normal” and surprisingly, functionality featured later
• Economic impact • Impact on the family • Impact on the health system
• This forms an important measure of the disease burden and thus need for intervention
Questions to ask about disease state
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Economic Impact
• Cost to patient and family • Cost of treating one episode (Acute illnesses) • Monthly or annual cost of treatment (Chronic illnesses) • Need for hospitalization and avg. length of stay • Analyze different components of the cost: Medication/device
treatment/hospitalization/outpatient setting cost
• Cost to health system • Annual cost of treatment to the health system • Annual cost of hospitalization to the health system
• Cost to society
• Low productivity due to absenteeism from work, • Loss of productivity due to disability of individual • Loss of productivity of caregivers • Loss of productivity due to death • Cost of caring for the disabled • Cost of treatment
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Questions to ask about disease state
More points to consider while analyzing the impact of disease:
A)Associated needs : Analyzing the symptoms may not be enough, disease may pose additional demands Example 1: Diabetes Diabetic patients need blood glucose testing that is less painful and less expensive These patients may also need help with comorbidities sich as heart disease and high blood pressure. Examlple 2: Bronchial Asthma Along with efficacious therapy, patients also need a reliable way to monitor disease and titrate therapy B) Long term sequelae: Example: Diabetic patients may need laser treatment for
retinal disorders, dialysis for renal failure, and specialized foot care to prevent ulcers
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How to conduct disease state analysis
1. Talk to a doc Requesting a doctor-friend for a brief overview may be the best starting point for a disease state analysis – provided that such help is available. Junior doctors and medical students may be equally helpful, and easier to find! • Have questions ready (the kind mentioned in this deck) • Keep it short (an hour may be all you need to begin with) • Doctors tend to go on a tangent, be polite but keep the discussion focused on what you need • Ask for a quick summary describing the CRUX of the matter • Ask for a quick primer on anatomy and physiology of the concerned system / organ • Ask for the most important issues surrounding a given disease • Ask for their wish-list (but don’t bias yourself with it) • Ask for key terms to search, read about • Ask for links to reference material
• For basic anatomy and physiology • For specific disease state
• In absence of statistics, try to get estimates based on their individual experience (remember these could have several biases)
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How to conduct disease state analysis
2. Need to read Begin with material describing anatomy and physiology Examples: Anatomy Gray’s Anatomy : Students edition; Clinical Anatomy : Moore and Dalley; Textbook of anatomy by BD Chaurasia ; Anatomy Atlas: F. Netter; visiblebody.com (paid
website, similar free services also available) Physiology Guyton’s textbook of Human Physiology (thick, but accessible); Ganong’s review of
Human Physiology; Textbook of Physiology by AK Jain; Principles of Medical Physiology by S. Sircar (thick, but accessible)
While anatomy textbooks may mainly help through illustrations, physiology text may be
more understandable, particularly the ones by Guyton and Sircar. Don’t be intimidated by the jargon – a broad idea is all you need
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How to conduct disease state analysis
3. Internet For general info a) google.com: your best friend for all types of searches! b) Medscape.net c) WebMD.com
For epidemiological info India specific data is hard to find a) http://www.rchiips.org/NFHS/index.shtml provides data on certain issues b) http://www.who.int/en/ has some Indian data For evidence on particular diseases, scholarly papers may help a) pubmed.net b) scholar.google.com
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Synthesis and Documentation
• Keep target audience in mind while writing the overview
• Site sources of all statistics, study results, interviews, and clinical outcomes
• Avoid unsubstantiated data from blogs and random news websites
• When plenty of compelling data is available, provide only a few relevant figures . The idea is to convey the point, not to bombard with information.
• In case of conflicting information rely on data from peer- reviewed journals.
• Tell a compelling, empathetic story, not a mere compilation of data
• In the Indian context TRIANGULATION is a CRITICAL SKILL.
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Learning Objectives
• Why analyze treatment options?
• What to consider while analyzing treatment options?
• How to analyze treatment options?
Treatment options
2
Learning Objectives
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analyze treatment options?
Why
1. To characterize the GAP 2. To define meaningful specifications for the desired solution 3. To understand what may work and what may not 4. To predict patient response to proposed solution
Disease state
Treatment options
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Analyzing treatment options..
1. Modern medicine provides treatment options for most of the common diseases
2. These treatment options have some desirable characteristics which often come at the price of certain non-desirable characteristics.
Desirable Characteristics Non-desirable Characteristics
Efficacy Cost
Safety Invasiveness
Painlessness Risk
Speed of action Need for skill
Lasting effect Need for infrastructure
Accessibility Poor availability
Table: Characteristics of treatment options
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Analyzing characteristics
Characteristics can be plotted on a graph Often a non-desirable characteristic increases along with a desirable one We seek to find the optima on this plot
Desirable Characteristics Non-desirable Characteristics
Efficacy Cost
Safety Invasiveness
Painlessness Risk
Speed of action Need for skill
Lasting effect Need for infrastructure
Accessibility Poor availability
Table: Characteristics of treatment options Non-desirable characteristic
Des
irab
le c
har
acte
rist
ic
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Analyzing characteristics : Cost vs Efficacy
Example
Desirable Characteristics Non-desirable Characteristics
Efficacy Cost
Safety Invasiveness
Painlessness Risk
Speed of action Need for skill
Lasting effect Need for infrastructure
Accessibility Poor availability
Fig: Plotting the characteristics of treatment options
Cost
Effi
cacy
High efficacy High Cost
Goal
High efficacy Low cost
Low efficacy Low Cost
Solution needs to have Efficacy better than this
Solution needs to Cost less than this GAP GAP
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Analyzing characteristics: Efficacy vs risk
Desirable Characteristics Non-desirable Characteristics
Efficacy Cost
Safety Invasiveness
Painlessness Risk
Speed of action Need for skill
Lasting effect Need for infrastructure
Accessibility Poor availability
Fig: Plotting the characteristics of treatment options
Invasiveness or Risk
Effi
cacy
High efficacy
High Risk
Low efficacy Low Risk
GAP
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Analyzing Characteristics: Efficacy vs skill required
Desirable Characteristics Non-desirable Characteristics
Efficacy Cost
Safety Invasiveness
Painlessness Risk
Speed of action Need for skill
Lasting effect Need for infrastructure
Accessibility Poor availability
Fig: Plotting the characteristics of treatment options
Skill required
Effi
cacy
High efficacy
High Skill
Low efficacy Low skill
GAP
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Analyzing characteristics : Safety vs cost
Example
Desirable Characteristics Non-desirable Characteristics
Efficacy Cost
Safety Invasiveness
Painlessness Risk
Speed of action Need for skill
Lasting effect Need for infrastructure
Accessibility Poor availability
Fig: Plotting the characteristics of treatment options
Cost
Safe
ty
High safety High Cost
Goal
Poor safety Low Cost
GAP
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Factors to consider while analyzing Rx options
Efficacy (therapeutic effect)
• Ability of the treatment option to treat/alleviate/ cure the disease • Most important factor • Measurement of efficacy
• Efficacy is measured through clinical trials • Randomized, controlled, triple blinded prospective trial or
Randomized controlled trial (RCT) is the gold standard • Other types of trials are Double blinded RCT, case control studies , • For an understanding of what an RCT is refer to this video http://www.youtube.com/watch?v=752V173e31o (24-29 minutes)
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A QUICK DEFINITION OF “TRUTH”
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Efficacy may be measured in different ways for different diseases and at times in different ways for the same disease as well Measuring mortality
• Increased life expectancy • Decreased risk of dying due to concerned disease • For diseases like cancer, survival for 5 years following treatment is considered
as a surrogate for cure
Measuring morbidity
• Risk of recurrence • Quality of life • DALYs lost etc • Efficacy in controlling specific symptoms like pain, bleeding, urinary frequency
The claim of a treatment being efficacious must be analyzed to find WHICH ASPECT is it efficacious in?
Efficacy Measurement: Chronic diseases
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Measuring mortality • Case fatality rate • Death during hospital stay • Death within 1 month of discharge
Measuring morbidity • Incidence of sickness absenteeism • Incidence of hospital admission • Average length of hospital stay • Need for intensive care • Time to regain full health and functionality • Measurement of specific symptom scores through questionnaires
Efficacy Measurement : acute diseases
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Factors to consider while analyzing Rx options
Cost of treatment • Indian perspective
• At times the most important factor driving choice treatment
• Even affluent patients are extremely cost conscious regarding healthcare expenses
• Nearly all healthcare expense comes out-of-the patient’s pocket
• The patient makes important therapeutic decisions, based on cost, hence there is greater pressure to make perceivable difference to the patient to justify cost.
(Unlike insurance driven systems where physicians make therapeutic choices)
• Low awareness level and cost consciousness bias patients towards low cost treatments – despite their low efficacy. This is a challenge.
Med-tech innovation in the Indian environment can be challenging
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Factors to consider while analyzing Rx options
Invasiveness • Invasiveness: Medical< Endoscopic < Surgical • For the same efficacy, a less invasive treatment is always preferred by doctors
and patients alike
Invasiveness or Risk involved in treatments for Prostate enlargement (BPH)
Effi
cacy
TURP High efficacy Less invasive
Lesser risk
Goal
DRUGS Low efficacy
Low Risk
GAP
SURGERY High efficacy
High Risk Very highly
invasive
Neotract, a novel device
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Risk profile, side-effects • Risk of side-effects in a current option may form the need for a novel
treatment. In the Prostate enlargement example, a 5% risk of permanent impotency necessitated the search for lesser invasive methods
• Side effects of drug therapy often lead to poor compliance with highly efficacious therapies
• Examples: • Side effects of low-cost iron tablets are a challenge in anemia therapy • Pain and swelling in the forearm – limit the use of continuous non-invasive BP
monitoring, while invasive monitoring has the risk of infection. • Pain and skin dystrophy limit the adoption of subcutaneous Insulin therapy
Desirable Characteristics Non-desirable Characteristics
Efficacy Cost
Safety Invasiveness
Painlessness Risk
Speed of action Need for skill
Lasting effect Need for infrastructure
Accessibility Poor availability
Factors to consider while analyzing Rx options
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Factors to consider while analyzing Rx options
Time of action • Time required for relief is an important factor • Time consuming therapies (such as those requiring prolonged
admission) may fall out of favor as the opportunity cost of such procedures may make them unaffordable, particularly for the economically weaker patient population
• Certain therapies (eg. Injectible steroids) –are used rampantly in India because of the rapid symptomatic relief they provide for relatively low cost – despite their positively harmful adverse effects.
• Rapid symptomatic relief is also responsible for widespread abuse of pain-killers.
• Both the above highlight Indian patients’ bias towards ‘QUICK relief’
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Factors to consider while analyzing Rx options
Home based Nebulization, CPAP, Blood sugar testing Out-patient procedure Banding for hemorrhoids, Fine needle Aspiration for Cytology, Incision and drainage, Pleural fluid tapping Day-Care procedure Arthroscopy, Shock Wave Lithotripsy, Laparoscopic Ligation, Tympanoplasty, Cataract Surgery, Minor breast Surgeries In-patient procedures All major surgeries, Laparoscopic surgeries etc
Setting of intervention: Examples
Incr
easi
ng
infr
astr
uct
ure
req
. an
d c
ost
s.
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Factors to consider while analyzing Rx options
Setting of intervention
There is a global trend towards downshifting the setting of procedure – with a view to saving infrastructure and manpower cost. Such a shifting of setting is even more important in the context of the Indian healthcare system, which is over-burdened and resource constrained.
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Factors to consider while analyzing Rx options
Requirement of skill
“There are more doctors of Indian origin, per American in USA, Than there are Indian doctors in India, per Indian” With such acute shortage of skilled manpower, any downshifting of a procedure on the skill spectrum would translate to greater access to the Procedure
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Factors to consider while analyzing Rx options
Through analysis of treatment options, try to understand: 1. Which are the most common treatments being used? 2. Who is providing them? 3. What profits are they are making? 4. What percentage of their total income does this disease/ treatment
contribute? 5. How will a cheaper/ safer solution affect these stakeholders? 6. There are examples where efforts to empower low-skilled workers to
conduct important procedures have met stiff resitance from influential stakeholders (specialist physicians) seeking to protect “their turf”
Such understanding will later, form the foundation for stakeholder
engagement strategy
Understanding the stakeholders
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Flow of care
1. Understanding the flow of care is critical. In an absence of such understanding, meaningful solutions cannot be envisaged 2. Try to find out: - What is the average time before medical advice is sought - Which is the first person/ facility that the patient contacts when symptoms surface - What is the skill and resource level of that facility - What is the next level of care that patient approaches - What investigations are required -What procedures are conducted, who conducts them - What is the average duration of treatment 3. In India, often the first point of contact is often under trained and
under resourced, while the larger facilities are reluctant to try new devices.
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Flow of care
Examples: 1. An ultra low cost ultrasound machine for rural areas sounds like a good
idea, until thought is applied to the fact that the machine itself is worthless in the absence of a radiologist to operate it and someone to interpret and act on the results
2. A nationwide medical record storage and retrieval service sounds like a
good idea until one realizes that concerned stakeholders may not have the time nor inclination to use it.
3. A low cost mobile phone based single lead ECG machine alone may not create a great impact until thought is applied to the following: - What conditions can a single lead ECG help diagnose? - What are the symptoms of those conditions? - Are those symptoms usually enough to drive a patient to a hospital? - Can any of these diseases be treated over the phone?
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How to conduct treatment option analysis?
1. Understanding of the disease state 2. If possible, a quick chat with a concerned physician may be a good
starting point 3. Material from sources like Medscape.com may provide further search
terms and links 4. Guidelines published by relevant professional and public health bodies
are exceedingly helpful. - There is one for most disease states. - These are based on international consensus and robust evidence. - A guideline document can form the backbone of a treatment option
study - A guideline doc is also a treasure trove of relevant references Examples : GOLD for COPD, IDSA for Hosp. acquired infections, AHA for
resuscitation, FIGO guidelines for Obgyn issues and so on
A: Secondary Research
5. Search further on pubmed.net, Google Scholar and other sources of literature. Market research reports may be helpful too.
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How to conduct treatment options analysis?
B: Primary Research
1. OBSERVE patients undergoing treatment. - See what they are DOING - Talk to them to find out what they SAY, - Figure how they FEEL and what they NEED 2. Caregiver interviews 2 Detailed Physician interviews. Don’t hesitate to email known
authorities in the field. You’ll be surprised at how often they respond. 3. Try to be non-judgmental. Refrain from confronting people with
scientific facts when you can guess they may not be aware of them. The idea is to glean information.
4. Collect rate-lists from hospitals and labs
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Note about health behaviors in India
1. Not all health related behaviors are driven by considerations of cost, efficacy, safety and comfort.
2. Superstitious and whimsical beliefs are almost universal Examples: a. Male sterilization (vasectomy) is much less invasive, less expensive, and safer than Female sterilization (tubectomy). Yet, majority of couples opt for tubectomy – the males do not accept the
procedure – despite the fact that it has no effect on sexual function. b. Blood donation is perfectly safe, yet voluntarily donated blood is perpetually in short supply – often Leading to maternal deaths c. Inhaled medication for Bronchial Asthma is a thousand times safer than oral medication, yet there is a widespread belief that inhalers are “strong” medicines leading to a “life long addiction”. Patients often prefer to suffer from Asthma than to use inhalers 3. Health often does not form a spending priority, particularly for the female members of the family
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Other facts to keep in mind
4. Health-care providers with no formal medical education (colloquially known as RMPs) provide a sizeable fraction of healthcare. No official data estimates or acknowledges their impact. They are
all pervasive – from big cities to small towns. Their primary focus is to maximize profits and are perhaps unlikely to invest in a new technology unless it translates directly to increased profits.
5. There is a common trend of consulting a “family doctor” (who could be an RMP, General physician
or any specialist) as a first point of contact. They then refer the patient to a doctor or facility of their choice
6. Auditing of prescriptions is very rare, and physician prescription habits may be out of sync with
current evidence (in smaller cities). Doctors in larger cities often keep abreast with current science.
7. A variety of factors (medical and non-medical ) decide what all investigations will be ordered.
8. A large, fragmented pvt. Sector delivers 80% of healthcare( 20% share belongs to a public sector).
9. The Laboratory medicine sector (estimated 50,000 labs ) is also disorganized with majority share belonging to small labs in the disorganized sector
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THANK YOU!