Umbilical Cord BloodUmbilical Cord BloodDubai Cord Blood Bank DCBBDubai Cord Blood Bank DCBB

CHAPTER ICHAPTER I

Background of Cord Background of Cord BloodBlood

WHAT IS CORD BLOOD?WHAT IS CORD BLOOD?

• “Cord Blood” is the blood found in the umbilical cord and is rich in life saving stem cells.

• Historically, the umbilical cord was considered “medical waste” and was discarded after delivery.

WHY IS CORD BLOOD SO SPECIAL?WHY IS CORD BLOOD SO SPECIAL?

• 10 years ago, the number of known treatable diseases, using cord blood, was 4!

• Currently, Cord Blood is used to treat over 75 different Cancers and Disorders

– Including: Leukemia, Lymphoma, Metabolic/Storage Diseases, Immunodeficiencies, Genetic Disorders, Neurological Disorders….

Donation country of treatment

2012 Adrenoleukodystrophy Donation child hungary St. Laszlo Hospital, Budapest2012 akute myeloische Leukemia Donation adult USA New York Presbytarian Hospital,

acute lymphoblastic leukemia Hospital de Clinicas, UniversidadeFederal Paraná, CurutibaCenter Hospitalier Lyn-Sud,Pierre-Benite

2012 Myelodysplastic Syndrom Donation adult great britain Royal Hospital for Children, BristolHospital de Clinicas, UniversidadeFederal Paraná, Curutiba

2012 acute lymphoblastic leukemia Donation Teenager canada The Hospital for Sick Kindren, Toronto2012 acute lymphoblastic leukemia Donation child USA Kindrens´s Hospital of Michigan, USA

Rome Transplant Network, PoliclinicoUniv. Tor Vergata

2011 acute lymphoblastic leukemia Donation adult canada Foothills Medical Center, Calgary2011 acute lymphoblastic leukemia Donation adult netherlands University Medical Center, Maastricht2011 acute lymphoblastic leukemia Donation adult netherlands University Medical Center, Maastricht2011 acute lymphoblastic leukemia Donation adult Denmark Rigshospitalet, Kopenhagen

Duke University Medical Center,DurhamStanford Hospital and Clinics,Stanford

2011 Myelodysplastic Syndrom Donation adult france Bordeaux Hospital2011 Pearson-Syndrom Donation Baby hungary St. Laszlo Hospital, Budapest

New York Presbytarian Hospital,New YorkU.O. Ematolologia, S.M dellaMisericordia, PerugiaUniversity of Kansas Hospital,Kansas CityWest Virginia University Hospitals,Morgantown

2010 severe combined immunodeficiency Donation Baby Tschechia University Hospital Motol, PragUniversity of Utah Cell TherapyFacility, Salt Lake City

2009 Myelodysplastic Syndrom Donation adult USA New York Presbytarian HospitalCity of Hope Hospital, Duarte,CaliforniaPaediatric University Hospital,BratislavaPaediatric University Hospital,BratislavaPaediatric University Hospital,BratislavaPaediatric University Hospital,BratislavaPaediatric University Hospital,Bratislava

1999 chronic myeloid leukemia brother/sister child Slovakia Paediatric University Hospital, Bratislava

2000 Diamond Blackfan Anemia brother/sister child Slovakia

2003 adrenoleukodystrophy brother/sister child Slovakia

2001 Diamond Blackfan Anemia brother/sister child Slovakia

2009 aplastic anemia brother/sister child Slovakia

2004 Medulloblastoma autolog (self) Baby Slovakia

2009 acute lymphoblastische Leukämie Donation adult USA

2009 Myelodysplastic Syndrom Donation adult USA

2010 acute lymphoblastic leukemia Donation Teenager USA

2010 acute lymphoblastic leukemia Donation adult USA

2011 acute lymphoblastic leukemia Donation adult USA

2010 lymphoblastisches Lymphom Donation adult italy

2011 Cerebral palsy autolog (self) child USA

2011 acute lymphoblastic leukemia Donation child USA

2012 acute lymphoblastic leukemia Donation child brasilia

2012 acute lymphoblastic leukemia Donation adult italy

2012 Donation child brasilia

2012 acute lymphoblastic leukemia Donation adult france

year Diagnostic Patient Hospital

Cord Blood Pricing

Plan today for a healthier tomorrow with DCBB

Simply choose one of our payment options that works best for your family.

How would you like to pay?Pay In Full $ 1, 995Pay In 6 months $ 343 / monthPay In 12 months $ 182 / month

You won't be charged until your baby's cord blood has been safely stored at our lab.

One-Time Service Fee: $1995* Includes cord blood collection kit, processing and the first year of storage.

Pay Annually $ 125Pre-Pay for 20 Yrs $ 1,975 Save $525Pre-Pay for 25 Yrs $ 2,300 Save $825

CHAPTER II

The ProcessThe Process

1. Form Completion2. Collection Kit Sent To Mother3. Mom brings kit to the hospital when in labor4. Cord Blood is Collected5. Cord Blood is picked up by the courier6. Cord Blood must be processed within 48 hours of cord blood collection!

THE PROCESS THE PROCESS OVERVIEWOVERVIEW

Mothers can access enrollment forms in two ways:1. By calling the Dubai Clinic, and requesting forms

to be mailed2. By visiting www. and downloading the forms

directly from the websiteEnrollment forms must be completed and

signed by the Mother and Physician for the unit to be processed

STEP 1: CONSENT FORM COMPLETIONSTEP 1: CONSENT FORM COMPLETION

STEP 2: REVIEW COLLECTION STEP 2: REVIEW COLLECTION KIT MATERIALSKIT MATERIALS

Foil Pouch

95k Transport Biohazard Bag

Collection bag

Maternal Tubes and Sleeve

Clamp

Gel Pak

Green Label

Alcohol and Iodine Pads/swabs

STEP 3: CORD BLOOD COLLECTIONSTEP 3: CORD BLOOD COLLECTION

• The cord blood collection is performed after the birth of the baby.

• The collection may be performed by the attending physician, nurse or midwife.

• The process is painless and easy to collect!

It takes a few minutes that It takes a few minutes that could save another’s life!could save another’s life!

• After the collection, the attending physician, nurse or midwife packages the cord blood.

STEP 4: PACKAGINGSTEP 4: PACKAGING

• After the cord blood is packaged, it is the responsibility of the mother to designate a person to notify the Dubai Cord Blood Bank

• At this time DCBB arranges a courier to pick up the cord blood from the mothers permanent room or the nurses station.

STEP 5: ARRANGING THE COURIERSTEP 5: ARRANGING THE COURIER

Umbilical Cord Blood Umbilical Cord Blood CollectionCollection

2 TYPES OF CORD BLOOD COLLECTIONS2 TYPES OF CORD BLOOD COLLECTIONS

• Vaginal

• C-Section

• A minimum collection volume of 85cc is needed for the cord blood to be considered usable.

• It is desirable to have a collection volume more than 100cc (above the top of the white label.)

C-SECTION DELIVERY

Volume! Volume! Volume!

Complete Paperwork

Do NOT Refrigerate!

CHAPTER V

Maternal Blood DrawMaternal Blood Draw

STEP 1STEP 1

• 5 vacutainer tubes have been supplied with the kit to draw the maternal blood for required infectious disease testing. The blood can be drawn during labor or shortly after birth; anytime within 48 hours of the cord blood collection, but must be drawn prior to cord blood kit packaging and courier pick-up.

• So long as the maternal blood is drawn within 48 hours of the cord blood collection, the maternal blood can be drawn at IV start or with other lab blood draws.

Maternal Blood Is Required With Every Collection!

STEP 2

Place the mother’s hospital ID labels on each tube of the maternal blood. If hospital labels are not available, write at minimum the mother’s full first and last name on the tubes.

STEP 3

Fill out the GREENGREEN label with the phlebotomist’s initials, date and time of collection, and place the completed green label on the absorbent tube-holder sleeve.

PACKAGING DIRECTIONS

All packaging directions pictured in the upcoming slides are located on the inside of the collection kit cover.

FINAL CHECK

IN ORDER TO MEET THE CRITERIA FOR A TRANSPLANTABLE UNIT PLEASE CONFIRM THAT:

THE BAG WEIGHT IS OPTIMUM > 155 GRAMSTHE VIALS WITH MOTHER’S BLOOD ARE LABELED WITH THE PATIENT’S FULL NAME (OR HOSPITAL ID LABEL)THE GREEN “VIALS FOR MOTHER’S BLOOD” LABEL IS COMPLETED AND ATTACHED TO THE ABSORBENT TUBE SLEEVETHE YELLOW “HUMAN CORD BLOOD” LABEL IS COMPLETED AND ATTACHED TO THE CORD BLOOD BAGTHE BLUE DELIVERY INFORMATION SHEET HAS BEEN COMPLETED AND ENCLOSED

5

PLACE COMPLETED YELLOW LABEL ON CORD BLOOD BAG.

ADDED PROTECTION

• Newborn Genetic Screening (inhouse or external partner)

• Newborn genetic screening is a unique process, separate from banking your baby’s cord blood. The process provides valuable information to parents by determining the risk your baby is at for a metabolic or other inherited disorder. These disorders can include flaws in body chemistry that can place newborns at risk for serious health complications.

• Only DCBB offers expecting families the added protection of newborn genetic screening with Health Check – a service that can detect nearly 60 disorders in newborns. This unique screening gives you the opportunity to protect your baby from the preventable complications of undiagnosed disorders. Many of these disorders are manageable if treatment begins early.

THANK YOU & CONGRATULATIONS!THANK YOU & CONGRATULATIONS!

YOU are helping to save lives by taking just a few minutes of your time!!