Ultrasound Bone Densitometer

confidential

Osteoporosis andOsteoporosis and Bone Densitometer

CM-200

Furuno Electric Co., Ltd.JAPAN

FURUNO ELECTRIC CO., LTD. All Rights Reserved.

Osteoporosis and our target sales route Osteoporosis and our target sales route

FURUNO ELECTRIC CO., LTD. All Rights Reserved. 1

H t M ?H t M ?全身DXA

How to Measure?How to Measure?DXA(Dual energy X-ray Absorptiometry) DXA(D l X Ab ti t )末梢DXA（橈骨など）

全身DXA

（腰椎、大腿骨近位部など）

( gy y p y)Peripheral part DXA(Dual energy X-ray Absorptiometry)

Lumbar spine, femoral neck

MD、DIP（中指骨）

MD(Micro Densitometry), DIP(Digital Image Processing)

Mid fingerQUS (Q tit ti Ult S d)QUS（踵骨）

QUS (Quantitative UltraSound)Calcaneus


P f H lth BP f H lth BPurpose for Healthy Bone Purpose for Healthy Bone

・ Prevail the awareness of potential fracture risk caused by Osteoporosis.

・ QUS for “screening”, and DXA f “d fi iti di i ”DXA for “definitive diagnosis”.

"Earl screening and earl treatment“・ "Early screening, and early treatment“ for the prevention of the fracture risk.


E l 1 (M t f i )E l 1 (M t f i )Example1 (Measurement for mass screening)Example1 (Measurement for mass screening)Group screening by Doctor's diagnosisQUS device

g

OrOr

QUS device is suitable for mass screening, for its easy operation

d i k t ti

Detailed examination by DXA Treatment with

and quick measurement time.After the screening, some patient might need detailed examination by DXA and other patient start


y eat e t w tmedication

by DXA, and other patient start medical treatment under doctor's diagnosis.

E l 2 (Di i b i t li i )E l 2 (Di i b i t li i )Example2 (Diagnosis by private clinic)Example2 (Diagnosis by private clinic)Treatment with medicationQUS device measurement

by clinic doctor

Measurement cost of QUS device is low compared with DXA, and the device is

ll f d b i t d t f

Doctor's diagnosis

generally preferred by private doctor for the usage of the osteoporosis diagnosis.The doctor prescribes a treatment drug based on the whole diagnosis such as QUS


based on the whole diagnosis such as QUS measurement result or health history of the patient.

Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company)

Part of Promotion

QUS device measurement

Part of Promotion

by pharmaceutical company

Treatment with one’s own product Some pharmaceutical company uses QUS devices for the promotion purpose of their

d t h t t t d f (medicine, or supplement)product such as treatment drug of osteoporosis or calcium supplement.Usually, these companies conduct the measurement for free in a hospital place and


measurement for free in a hospital place, and apply the drug or supplement to the person who suspected to have osteoporosis.

D f T ti O t iD f T ti O t iDrug for Treating Osteoporosis Drug for Treating Osteoporosis Method Therapeutic Drug Therapeutic EfficacyMethod Therapeutic Drug Therapeutic EfficacyInjection Teriparatide Accelerates the formation of new bone.Injection Calcitonin Alleviation of pain caused by osteoporosis.Injection Calcitonin Alleviation of pain caused by osteoporosis.

Prevent the breaking of old bone.Internal use

Drip infusionBisphosphonate Prevent the breaking of old bone.

Drip infusionInternal use selective estrogen receptor

modulator 【SERM】Prevent the breaking of old bone.

Injection Anti-RANKL Antibody Prevent the loss of calcium from bones.Internal use Activated Vitamin D Enhances absorption of calcium from food substance,

and accelerates the formation of new bone.and accelerates the formation of new bone.Internal use Vitamin K Accelerates the formation of new bone.Internal use Calcium Supplies Calcium as additional nutrition


Introduction of CM-200Ul d b d iUltrasound bone densitometer


Steady Sales PerformanceSteady Sales PerformanceCM-100 & CM-200

Volume of shipment (oversea)CM-100 & CM-200 Volume of shipment (oversea)CM 100 & CM 200 Cumulative Sales Data

PRODUCT CM-100 CM-200

CHINA 19 492CHINA 19 492INDIA 0 69

VIETNAM 1 18TAIWAN 43 10

MALAYSIA 0 4MALAYSIA 0 4PHILIPPINES 2 8

UAE 0 2KSA 0 2

KUWAIT 0 1KUWAIT 0 1BRAZIL 0 1

SRI LANKA 0 1KOREA 183 0

INDONESIA 1 0INDONESIA 1 0PAKISTAN 2 0

EGYPT 9 0JAPAN 2198 1563


TOTAL 2458 2171TOTAL:4629

(as of end of Jan, 2014)

Comparison chartComparison chartComparison chartComparison chartManufacturer FURUNO OsteoSys GE

Model CM-200 SONOST-3000 Achilles EXPIIMeasurement Site Calcaneus (Heel Bone) Calcaneus (Heel Bone) Calcaneus (Heel Bone)

Parameter SOS SOS /BUA SOS/BUA

Results T-score with % young adultZ-score with % age-matched

BQI Index T-score with % young adult

Z-score with % age-matched

Stiffness Index T-score with % young adult

Z-score with % age-matchedH l T C ti H l T S N NHeel Temp. Compensation Heel Temp. Sensor No No

Scanning Time Less than 10 sec Less than 15 sec Less than 10 sec

Precision < 0.5% CV (in vitro) < 2.0% CV ( in vivo) < 2.0% CV ( in vivo)

Foot Plate Adjustable plate structure (5 levels) Replaceable plate Replaceable plate

Measurement block Full dry coupling with Ultrasound Gel Full dry coupling with Ultrasound Gel using alcohol and silicon membrane

Probe Movement Manual Motorized (automatic adjustment) Fixed probe, Expandable membrane with water

External Monitor support Standard Component Option Option

Built-in Printer Thermal Printer Thernal Printer Thernal Printer

Display Color LCD Color LCD Color LCD

Dimension (mm) 510 x 300 x 210mm 300 x 620 x 390 mm 281 x 305 x 560 mm

Weight 11 kg 12kg 11.5 kgg g g g

Consumable Parts Thermal Printer paper Thermal Printer paper Thermal Printer paper, silicon membrane

MODEL


PICTURE

Safety and Speedy measurementSafety and Speedy measurement

S f tSafetyUltrasound method requires no special facilities. With radiation exposure-free, it allows to all generation including children to pregnant women to measure.

SpeedySpeedyApprox. 10 seconds required for measurement.


Result DisplayResult Display

C l h f lt i di l d f ltColor graph of result is displayed for easy result monitoring.

Simple Print-out Sheet


Precision measurement (H l t t )Precision measurement (Heel temperature sensor)

Thi d i f ti d l d b FURUNOThis new and unique function developed by FURUNO provides accurate results by offsetting the result with heel temperat reheel temperature

Heel Temperature Sensor


Precision measurement (H l t t )

Temperature sensor - ON

Precision measurement (Heel temperature sensor)

Temperature sensor- OFFTemperature sensor - ON

1570

1580

1590

1600

Temperature sensor OFF

1570

15801590

1600

1530

1540

1550

1560

1570

OS

[m/s

]

15301540

1550

15601570

SO

S [m

/s]

OCTJAN

OCTJAN

1490

1500

1510

1520SO

14801490

15001510

1520

S JANFEB

JULYAUG

MARAPR

JANFEB

JULYAUG

MARAPR

1470

1480

1470

1480

1490

1500

1510

1520

1530

1540

1550

1560

1570

1580

1590

1600

SOS (Sep.) [m/s]

1470

1480

1470

1480

1490

1500

1510

1520

1530

1540

1550

1560

1570

1580

1590

1600

SOS (Sep.) [m/s]

AUG1:1

AUG1:1

When the temperature sensor is ON, results is on the green line which shows the ideal condition The feature enables accurate SOS


shows the ideal condition. The feature enables accurate SOS measurement regardless of seasonal condition.

14

Precision measurement (F t Si Adj t t)

Th f t l t b dj t d t 5 l l b

Precision measurement (Foot Size Adjustment)

The foot plate can be adjusted to 5 levels by operating the dial, and makes more accurate measure at the best position of heel in an eas operationat the best position of heel in an easy operation.(19cm, 20cm, 21cm, 22 to 24cm and above 25cm) .

Provides accurate SOS for children.

Study show most of 10-year-old children have footStudy show most of 10-year-old children have foot size above 19cm.


Utility Software

C t CM 200 t t l PC

Utility Software

Connect CM-200 to an external PC.Type patient information and click Start button on a

PC screen.Measurement results will be saved on PC and

managed as the PC file.Result graph, trend graph and QC graph can beResult graph, trend graph and QC graph can be

printed from the printer connected to the PC.


Utility SoftwareUtility Software


SpecificationsSpecificationsMeasurement Site Heel (Calcaneas)S ( )

Measurement Method Ultrasound Pulse Penetration

Measuring Parameter SOS:Speed of Sound

Measurement Time Approx. 10 SecMeasurement Time pp

Measurement Precision%CV Less than 0.5%（in measurement of Phantom）

Ultrasound Frequency Center Frequency: 500 kHz

Ultrasound Output Isptp： 1.8mW/cm2

Measurement Block Dry Type (acoustic gel used)

Operating EnvironmentTemperature: 10 - 35°C

Operating EnvironmentHumidity： 30 – 85%RH (Non Condensing)

Storage EnvironmentTemperature： -10 - 50°CHumidity： 30 - 85%RH (Non Condensing)

Power Supply 220VAC±10%pp y

Rated Frequency 50Hz/60Hz

Consumption Current 0.3A or less

Dimensions 510 (W) x 300 (W) x 210 (H) mm


Mass 11 kg (Approximately)

Thank you for your attentionThank you for your attentionThank you for your attentionThank you for your attention


Ultrasound Bone Densitometer

Healthcare

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