Ullman Design infographics 2015

a creative studio

We are a team of creatives with varied talents that allow us to converge art with design; marketing with communication; interactive media with branding. The result: Work that is not only innovative, aesthetically pleasing and practical, but functional and informative. Integration of our capabilities in visual communication, brand development, ilustration and interactive media is the spark that fuels our creative energy.

we embrace creativity. | We believe design is not a beauty contest. Rather, it is a process of exploring options and being open to different ideas and perspectives to find the best approach to deliver a message. Our work illustrates our style and vision.

We have a our passion for creating quality work. Our keen interests in multiple disciplines and our inquisi-tive natures continually assists us with finding solutions to problems. These are personal attributes that make our studio team effective communicators.

we are storytellers. | We understand that design is about more than just a look. It is a voice. It is a message that resonates from stories to the reader. It is about creating an organizational balance that guides readers through content. It is a unique combination of visuals with text in a design that creates a engaging narrative that captures a sense of place, and tells a story the reader or audience can relate to on many levels.

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collaborate. learn. innovate.

about our studio

graphics

section1

informational

and scientific illustration

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Minimally invasive 3-D robotics technology enables surgeons to perform operations with just a few small incisions instead of through open surgery, resulting in less pain and a shorter recovery. Approved in 2000 by the Food and Drug Administration, the da Vinci Surgery System was the first to be used for general laparoscopic surgery. Nationwide Children’s Hospital is one of nearly 1,400 hospitals in the nation that utilizes the technology.

Robot-assisted minimally invasive surgery

The system at Nationwide Children’s has four arms, three used to guide instruments at the surgical site (A) and one for positioning a camera (C) with two lenses that gives surgeons full stereoscopic vision from the console.

The da Vinci system

Assistant

Surgeon at operative console

Assistant

Nurse

Anesthesiologist

Surgical applications

The vision cart is the hub for various parts of the surgical system. The consoles, robotic arms and monitors in the operating room feed into the vision cart, which connects to a central computer system that collects data on instrumentation and surgeons’ movements.

Surgeons at Nationwide Children’s use the robotic equipment to perform a range of procedures in urology and general surgery, including operations to treat such problems as urinary reflux, birth defects in the urinary tract, kidney disease, Crohn’s disease and appendicitis.

Vision cart

The robotic arms bend and twist just like human hands and wrists—only steadier—and allow surgeons to place sutures that are far more difficult to do in traditional laparoscopy.

Robotic hands

The surgeons’ view of the surgical site is much closer than human vision allows, thanks to a 3-D vision system built into the console.

Magnified view

The surgeons sit at control consoles just a few feet away from the operating table, using two joystick-like controls and foot pedals to control the instruments and camera held by the robotic arms. The arms remain locked until the surgeon places his head in the viewfinder on the control console. The system translates the surgeon’s movement of the controls into smaller, more precise movements by the robotic arms.

Control console

Full rotation

Pivot head

5 cl ient: Joslin Diabetes Center at Harvard | topic: How inflamation impacts diabetes | 4 cl ient: Nationwide Children’s Hospital | topic: Robot-assisted minimally invasive surgery

5 cl ient: The Wise Group | topic: TMJ

5 cl ient: University of Chicago Hospital, Medicine on the Midway magazine 5 cl ient: Oregon State University, Terra magazine | topic: Johne’s Disease

topic: How the braingate system works

fig. 1.1 client name | description

Immune function

When foreign pathogens enter the body, the immune system recruits phagocytes such as monocytes and neutrophils to fight them.

Monocytes mature into macrophages

B cells and T cells spawn memory cells that recognize and eliminate previously encountered pathogens.

Antibodies are created that bind specifically to the foreign antigens.

The cells of the adaptive immune system are called lymphocytes. The two primary types, B cells and T cells, carry receptor molecules that recognize specific targets.

A D A P T I V E I M M U N E S Y S T E MI N N AT E I M M U N E S Y S T E M

Neutrophil

Blood stream

1

The macrophage engulfs the pathogens and kills them.

2

The pathogens are broken down into pieces inside the cell.

3

The remains are displayed on the cell’s surface with the aid of a class of receptors that include Human Leukocyte Antigen (HLA)-DR. A pro-inflammatory cytokine is secreted to help stimulate the immune system to fight the infection.

4

Activated B cells secrete antibody molecules that bind to antigens and destroy the invader or mark it for attack by other cells.

5

Cytotoxic T cells recognize their targets by binding to antigen present on the surface. Individual T cells are able to recognize only certain antigens that match their type of receptor.

6

The cytotoxic T cells destroy infected cells by releasing cytotoxins and a protein called perforin and cytotoxins. Perforin makes a hole in the membrane of the infected cell. The cytotoxins enter the cell through this hole and destroy the cell and the pathogen inside.

7

Monocyte

Cytokines

B cell receptor

B cell

Memory B cell

T cell

Infected cell displaying antigen

Memory T cellActivated B cell

Anibodies

Macrophage

Infected cell being destroyed

Unlike the innate immune system, the adaptive system almost always requires the detection of a specific antigen to switch itself on. If the monoctyes don’t display these pieces of antigen on their cell surface, the adaptive systems stays off.

The innate immune system is the body’s first line of defense, comprising the cells and mechanisms that recognize and

respond to bacteria, viruses and other pathogens.

5 4 cl ient: Nationwide Children’s Hospital | topic: Immune function

5 cl ient: Genetics and Public Policy Center at Johns Hopkins University | topic: Cloning

5 cl ient: Ohio University, Perspectives magazine | topic: Astronomy


5 cl ient: Harvard University, Harvard Medicine magazine | topic: The development of Velcade

5 cl ient: Whitehead Institute at MIT, Paradigm magazine | topic: Transcription and the human genome

5 cl ient: University of Chicago Hospital, Medicine on the Midway magazine | topic: Glucose metabolism | 4 cl ient: Whitehead Institute at MIT, Paradigm magazine | topic: Cancer

In the centromere, histone H3 is replaced by a histone variant called CENP-A. The kinetochore develops on the side where the CENP-A histones are present.

chromosome

centromere

area of detail

Kinetochore

Kinetochore microtubules

chromatid

chromatin fibrils

These protein complexes mediate the attachment of chromosomes to the mitotic spindle.

h3

ceNP-A

disc structure

The centromere of each chromosome has a very compact structure and a unique composition of nucleosomes.

Threads connect the centromere to opposite sides of a dividing cell, allow each chromosome to be split in half.

tHe kinetocHore

ExxonNo. 1 Gainer-Lee

AmeradaNo. 1 Ullman

Lease hold area of interest

Pan AmNo. 1 Windbigler

OHIO

WEST VIRGINIA

ExxonNo. 1 Gainer-Lee

5

AmeradaNo. 1 Ullman

3

55

10

5

1010

15

20

5

15

Pan AmNo. 1 Windbigler

1

To Lima-Indiana

field

Permian

L+M DevonianL+M Devonian

Ohio West Virginia

SW

NW

Pennsylvanian

Upper Devonian

L+M Devonian

Mississippian

Cambrian

Silurian

Utica

Cambrian

8,000

4,000

2,000

metersfeet

miles

kilometers

1,000

10 20 30

20 400

Land surface

Land surfaceSea level

Sea level

Lease hold area of interest

High oil saturation

Utica shale source rock

Gas converted from oil

Drill hole(depth in 1,000s of feet)

Igneous and metamorphic rocks of the Grenville province

GeoloGy.01

pa g e 7 of 1 7

The Ordovician-aged Utica Shale is distributed across several states as well as Quebec and is

found 2,000+ ft below the Marcellus Shale. The shale generally shallows moving east to west.

The formation throughout the majority of Pennsylvania (except NW) will likely produce dry gas,

which is evident from Range Resources test well in Butler County, PA that was rumored to have

IP’d around 9 MMcf/d. Moving west, the Utica becomes oilier and less mature.

The below illustration (figure 1) shows that gas prone areas of the formation will be in the deeper

portion of the basin which is located in Pennsylvania and West Virginia; much of Ohio is expected

to contain appreciable amounts of oil.

fig.5

section

n u t i ca s h a le o p p o rt u n i t y 5 cl ient: Cunningham Energy | topic: Utica shale geographic location

5 cl ient: Ludwig Institute for Cancer Research | topic: CENP-A

5 cl ient: University of Chicago Hospital, Medicine on the Midway magazine | topic: MRSA

5 cl ient: Cincinnati Children’s Hospital Foundation, Annual Report 2011 | topic: Cystic fibrosis

3 cl ient: Institute for Cell Engineering

at Johns Hopkins University | topic: Stem cells

This process combines electrospray and desorption ionization methods in which an electrically charged mist is sprayed onto a sample surface. Voltage applied to the sample holder causes the surface to attract the electrospray mist. Once ionized, the ions travel through air to the inlet connected to a mass spectrometer.

inlet of mass spectrometer

desOrpTiOn elecTrOspray iOnizaTiOn (desi)

desorbed ions

charged droplets

solvent

nebulizing gas (N2)

power supply (KV)

sample

charged surface

5 cl ient: Ohio University, Perspectives magazine

topic: Desorption electrospray ionization (DESI) technology

5 cl ient: Whitehead Institute at MIT, Paradigm magazine | topic: Human genome / transcription factor 5 cl ient: Whitehead Institute at MIT, Paradigm magazine | topic: Neurological disease treatment

cl ient: Dr. David Bayless, Ohio University Russ College of Engineering | topic: Fossil Generation Plant with Bioreactor

cl ient: Oregon State University, Terra magazine | topic: Fighting Sepsis Infection

cl ient: Ohio State University Stone Laboratory | topic: Energy education kiosk graphics

cl ient: Ohio State University Stone Laboratory | topic: Energy education kiosk graphic

5 cl ient: Ohio University, Perspectives magazine | topic: Protein CLIC5

5 cl ient: Ludwig Institute for Cancer Research | topic: CENP-A loading

The diagram shows the loading of nucleosomes containing the histone variant CENP-A into the centromere region of chromosomes during the cell cycle.

loadingHistones

[1 ] During mitosis (separation of chromosomes during cell division), chromosomes align and attach to the mitotic spindle.

[3 ] In early G1, CENP-A nucleosomes assemble, but are not incorpo-rated until after the cell has divided.

ceNP-A assembly

histone h3 exchange

chromatin assembly

Nucleosomes

centromere

chromosome

Kinetochore

mitosis

ANAPhAseteloPhAse

[2 ] The chromosomes spit apart at the centromeres.

half of chromosome

G2 PhAse

[5 ]As the cell completes its division, the replicated CENP-A and H3 nucleosomes are included in the replicated chromosomes that form the nucleus of the new cells.

s PhAse

[4 ]Normal H3 nucleosomes are incor-porated into chromosomes when the chromosomes replicate, and the CENP-A nucleosomes are evenly distributed between the two centromere copies and mixed up with the H3 nucleosomes.

One powerful protein

It can impact hearing, cancer, wound healing and more

THE IMPACT OF CLIC5 ON

Cytoskeleton

A protein called CLIC5 plays an important role in triggering disease and cancer. Ohio University scientists Mark Berryman and Soichi Tanda are studying CLIC5 in two models: the microvilli of the eye cells of fruit flies and the stereocilia in the inner ear of genetically modified mice that are deaf and have difficulty with spatial orientation.

In ear cells, deregulation of CLIC5 severely alters the structure of stereocilia by disconnecting the membrane from the cytoskeletal support filaments just underneath it.

Microvilli

Stereocilia

NORMAL C L I C 5

4Cell brush border

Section of villus

Mucosal wall

Cell brush border

Both microvilli and stereocilia are tiny finger-like protrusions on the surface of cells, but they can have different structures and forms. Each protrusion is supported internally by cytoskeletal actin filaments.

Villi are composed of single cell border consisting of thousands of microvilli that create a brush-like border that aids in processes such as absorption of light or—in the case of the human gut—nutrients.

Cell

At the apex of each microvilli is a cellular tip link which opens and closes ion channels that let sound or light into the cell.

4

DEREGULATED C L I C 5

Detatched Cytoskeleton

Deregulated CLIC5

Cochlear cell surface

Ear

Cochlear

Bristle-like stereocilia line the surface of the cell.

Normal stereocilia

In sensory hair cells in the inner ear, stereocilia form elaborate arrays that respond to minute vibrations and send electrical signals to the brain. If the tip links of stereocilia in ear cells get damaged, hearing loss can occur. When the protein CLIC5 is deregulated, these tip links break and impede sensory function.

CLIC5CLIC5 acts as the glue between the cytoskeleton and cell membrane.

Damaged stereocilia

story by :: PHILIP BARNES

cl ient: Nationwide Childrens Hospital, Pediatrics Nationwide magazine | topic: Femoral nerve block procedure in knee surgery

cl ient: Nationwide Childrens Hospital, Pediatrics Nationwide magazine | topic: Exosome therapy process to treat liver fibrosis

Ullman Design infographics 2015

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