U2L3 - Electron Transport Chain copy · Electron Transport Chain. When electrons are accepted by...
Transcript of U2L3 - Electron Transport Chain copy · Electron Transport Chain. When electrons are accepted by...
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CELLULAR RESPIRATIONSTAGE 3: ELECTRON TRANSPORT CHAIN
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Electron Transport Chain
matrix
intermembranespace
cristae
outer membrane
Mitochondrion (cross-section)
matrix
intermembranespace
Electron transport chain occurs on inner membrane (cristae)Involves a series of membrane proteins (cytochromes)
cytochromes
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NADH and FADH2 (produced during CAC) give up H+ ions and electrons to cytochromes
H+ ions accumulate in intermembrane spaceElectrons are transported through chain of cytochromes
Electron Transport Chain
matrix
intermembranespace
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Gradients drive H+ ions through protein channel, providing energy to synthesize ATP
High concentration of H+ ions in intermembrane space creates concentration gradient and electrostatic gradient
matrix
intermembranespace
high [H+]
low [H+]
Electron Transport Chain
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As electrons released by NADH and FADH2 move through ETC, each cytochrome is alternately reduced and then oxidized, until electrons combine with final electron acceptor, oxygen
high [H+]
low [H+]
intermembranespace
matrix
Electron Transport Chain
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When electrons are accepted by O2, H+ ions are also picked up, resulting in formation of H2O
½O2 2H+ H2O+
high [H+]
low [H+]
intermembranespace
matrix
Electron Transport Chain
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Aerobicglucose
Glycolysis
2 pyruvate
2 ATP2 NADH
PyruvateOxidation
2 acetyl CoA
Kreb’s Cycle
2 NADH2 CO2
6 NADH2 FADH2
2 ATP4 CO2
E.T.C.
6 ATPx3
x3
x2
6 ATP
18 ATP4 ATP
2 ATP
2 ATP38 ATP
6 Cx3
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Lactic acid is toxic biproduct
2 ATP
In animals, this occurs through lactic acid fermentationFor glycolysis to continue, NAD+ must be replenished
glucose
Anaerobic
Glycolysis
2 pyruvate
2 NADH
2 lactic acid
2 NAD+
Lactic AcidFermentation
Total production of 2 ATP per glucose molecule
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2 ATP
In bacteria and yeast, this occurs through alcohol fermentation
glucose
Anaerobic
Glycolysis
2 pyruvate
2 NADH
2 ethanol
2 CO2
AlcoholFermentation
Total production of 2 ATP per glucose molecule
2 acetaldehyde
2 NAD+
For glycolysis to continue, NAD+ must be replenished