Typhoid Fever Pathophysiology
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Pathophysiology Signs/Symptoms Complications Etiology: Ingestion of food or uids contaminated with Salmonella Precipitating Factors: • Poor hand hygiene • Unpuried drinking water • Unsanitary Preparation of food Predisposing • Geographical area – tropical islands in the Pacic Philippines! and "sia In%ades the Peyer&s patches of the intestinal wall in the small intestine where it attach incubation period is rst '()* days +acteria enter the stomach , sur%i%e a p- as low +acteria will then in0ects to1ins known as the e2ector proteins into the int est ina l cel ls and int errupts wit h the cel lul ar prote ins , lip ids , manipulate their function resulting in phagocyti3ation of the epithelial cell membrane until it is engulf down into the inferior part of the host 4nter bloodstream %ia lymphatics Peyer&s Ulceration and bleeding in the mucosal lining and leads to necrosis. 5issu e damage and inammation causes loss of abso rp tion due to damaged %illi causing an increase in water6 ele ctr oly tes 6 mucus6 blo od6 and serum to be pu lle d into the 5he bacteria is within the macroph ages and sur %i %es. +acteria spread %ia the ly mp ha ti cs whil e in side th e 7acrophages , intestinal epithelial cells then attract 5 cells , neut rop hils with inter leuk in 8 I9(8 causing inammation of the 5he bacteria induced macropha ge apoptosis 6 breaking ou t into the bloodstream and cause systemic infection. Coplications: Intestinal hemorrhage 5 yphoid psyc hosis :idney or bladder infections P a n c r e a t i t i s !igns" syptos: "bdominal pain epigastric area! of );/); pain scale with "bdominal spasm is induced to limit mucosal in0ury adding in stimulation of increased !igns" syptos: <eakness6 =omitting episodes6 >e%er6 #yphoid !igns" syptos: ?efecates *( times6 hyperacti%e bowel sounds dry skin6 anore1ia6 Per forati on an d destruct io n of mucosal lining of the intestinal wall can lead to persistent inammation.
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Transcript of Typhoid Fever Pathophysiology
7/18/2019 Typhoid Fever Pathophysiology
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Pathophysiology
Signs/Symptoms
Complications
Etiology:Ingestion of food or uids
contaminated with Salmonella
Precipitating Factors:
• Poor hand hygiene
• Unpuried drinking water
• Unsanitary Preparation of food
Predisposing
• Geographical area – tropical
islands in the PacicPhilippines! and "sia
In%ades the Peyer&s patches of the intestinal wall in the small
intestine where it attach incubation period is rst '()* days
+acteria enter the stomach , sur%i%e a p- as low
+acteria will then in0ects to1ins known as the e2ector proteins into theintestinal cells and interrupts with the cellular proteins , lipids ,manipulate their function resulting in phagocyti3ation of the epithelialcell membrane until it is engulf down into the inferior part of the host
4nter bloodstream %ia lymphatics Peyer&s
Ulceration and bleeding in the
mucosal lining and leads to necrosis.
5issue damage and inammation
causes loss of absorption due to
damaged %illi causing an increase in
water6 electrolytes6 mucus6 blood6
and serum to be pulled into the
5he bacteria is within the
macrophages and sur%i%es.+acteria spread %ia thelymphatics while inside the
7acrophages , intestinalepithelial cells then attract 5 cells, neutrophils with interleukin 8I9(8 causing inammation of the
5he bacteria inducedmacrophage apoptosis6 breakingout into the bloodstream andcause systemic infection.
Coplications:Intestinal hemorrhage
5yphoid psychosis:idney or bladderinfections
Pancreatitis
!igns"syptos:"bdominal
painepigastricarea! of );/);pain scale wit
"bdominal spasm is
induced to limit mucosal
in0ury adding in
stimulation of increased
!igns"syptos:
<eakness6=omitting
episodes6 >e%er6
#yphoid
!igns" syptos:?efecates *( times6 hyperacti%ebowel sounds dry skin6 anore1ia6
Perforation and destruction of
mucosal lining of the intestinal wall
can lead to persistent inammation.
