tumour investigations Acridine-decorated cyclometallated ... · S1 Acridine-decorated...
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S1 Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti- tumour investigations Morwen R. M. Williams, a Benoît Bertrand,* a,b Julio Fernandez-Cestau, a Zoë A. E. Waller, c Maria A. O’Connell, c Mark Searcey,* a,c and Manfred Bochmann* a a School of Chemistry, University of East Anglia, Norwich, NR4 7TJ (UK) Email: [email protected] b Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire (IPCM), F-75005 Paris, France c School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ (UK) Supporting informations Contents Page Figure S1: Correlation between IC 50 and cell uptake of complexes 2, 6, 7 and 11 in MCF-7 cells. S2 Figure S2: 1 H NMR spectra of a 1:1 mixture of 7 with GSH at room temperature, in comparison with the starting materials, 7, GSH and GSSG (DMSO-d 6 /D 2 O 1:1). S2 Figure S3-S17: NMR spectra of complexes 4, 6-11 S3-S16 Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is © The Royal Society of Chemistry 2018
Transcript of tumour investigations Acridine-decorated cyclometallated ... · S1 Acridine-decorated...
S1
Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations
Morwen R. M. Williams,a Benoît Bertrand,*a,b Julio Fernandez-Cestau,a Zoë A. E. Waller,c Maria A.
O’Connell,c Mark Searcey,*a,c and Manfred Bochmann*a
a School of Chemistry, University of East Anglia, Norwich, NR4 7TJ (UK)
Email: [email protected] Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire (IPCM), F-75005 Paris, Francec School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ (UK)
Supporting informations
Contents Page
Figure S1: Correlation between IC50 and cell uptake of complexes 2, 6, 7 and 11 in MCF-7 cells.
S2
Figure S2: 1H NMR spectra of a 1:1 mixture of 7 with GSH at room temperature, in comparison with the starting materials, 7, GSH and GSSG (DMSO-d6/D2O 1:1).
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Figure S3-S17: NMR spectra of complexes 4, 6-11 S3-S16
Electronic Supplementary Material (ESI) for Dalton Transactions.This journal is © The Royal Society of Chemistry 2018
S2
Figure S1: Correlation between IC50 and cell uptake of complexes 2, 6, 7 and 11 in MCF-7 cells.
Figure S2: 1H NMR spectra of a 1:1 mixture of 7 with GSH at room temperature, in comparison with the starting materials, 7, GSH and GSSG (DMSO-d6/D2O 1:1).
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4
1 2
3
4567
8910
11 12
1314
1516
17
1819
20
NAu
tBu
N OO
Figure S3: 1H NMR spectrum of complex 4 in CD2Cl2.
S4
Figure S4: 13C{1H} NMR spectrum of complex 4 in CD2Cl2
S5
6
NAu
tBu
N NO O
1 2
3
4567
8910
11 12
13
14
151617
1819
20 22
21
Figure S5: 1H NMR spectrum of complex 6 in CD2Cl2.
S6
Figure S6: 13C{1H} NMR spectrum of complex 6 in CD2Cl2
Figure S7: 13C-1H HMQC spectrum of complex 6 in CD2Cl2 showing C20+22.
S7
7
NAu
tBu
N ON
1 2
3
4567
8910
1112
13
14
1516
17
18
19
20
2124
25
23 22
Figure S8: 1H NMR spectrum of complex 7 in CD2Cl2 (tert-Bu singlet at 0.35 ppm not shown).
S8
Figure S9: 13C{1H} NMR spectrum of complex 7 in CD2Cl2.
S9
8
AuN
ONN
1 23
45
67/7'
89
1011
12
13
14
15
1617
18
192021
24
2523
2226
Figure S10: 1H NMR spectrum of complex 8 in CD2Cl2 (263 K).
S10
Figure S11: 13C{1H} NMR spectrum of complex 8 in CD2Cl2.
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9
NAu
tBu
NHNN
12
3
4567
8910
11 12
13
14
15 16
17
18
19
2021
24
25
2322
Figure S12: 1H NMR spectrum of complex 9 in CD2Cl2 (tert-Bu singlet at 1.46 ppm not shown).
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Figure S13: 13C{1H} NMR spectrum of complex 9 in CD2Cl2.
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10
N
N
tBu tBuAu
SbF6
NHRHN
123 4
56
789
1011
1213
14
15
16 17
18
1920
21 22
2324
NR=
Figure S14: 1H NMR spectrum of complex 10 in (CD3)2SO.
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Figure S15: 13C{1H} NMR spectrum of complex 10 in (CD3)2SO.
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11
N
N
tBu tBuAu
PF6123 4 5
6
7
8910
11 12
13
1415
16
17 18
19
20
NR=
N NR
Figure S16: 1H NMR spectrum of complex 11 in CD3CN
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Figure S17: 13C{1H} NMR spectrum of complex 11 in CD3CN.
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