Tumor markers ppt BIOCHEMISTRY
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Transcript of Tumor markers ppt BIOCHEMISTRY
Tumor markersDr Vijay Marakala M.D
BIOCHEMISTRYSIMS &RC
TUMOR MARKERS
OUTLINE
Definition Clinical uses
Classification Examples
TUMOR MARKERS
Substance found in increased amounts in the blood, other body fluids and tissues that
may suggest the presence of cancer
Definition
CLINICAL APPLICATIONS OF TUMOUR MARKERS
Diagnosis Prognosis Monitor treatment
Detection of
recurrenceScreening
CLASSIFICATION OF TUMOUR MARKERS
Hormones Oncofetal Antigens
Enzymes Tumor-
Associated Proteins
TUMOR MARKERS - Hormones
Human chorionicgonadotropin
• Gestational trophoblastic disease
• Gonadal germ cell tumor
Calcitonin
• Medullary cancer of the thyroid
Catecholamines
• Pheochromocytoma
TUMOR MARKERS – Oncofetal antigens
• Hepatocellular carcinoma,
• Gonadal germ cell tumor
α-Fetoprotein
• Adenocarcinomas of the colon, pancreas, lung, breast, ovary
Carcinoembryonicantigen
TUMOR MARKERS - Enzymes
• Prostate cancerProstatic acidphosphatase
• Small cell cancer of the lung,• Neuroblastoma
Neuron-specificenolase
• Lymphoma, • Ewing's sarcoma
Lactatedehydrogenase
TUMOR MARKERS - Tumor-Associated Proteins
Prostate-specific antigen
Prostate cancer
Monoclonal immunoglobulin
Myeloma
CA-125
Ovarian cancer
CA19-9
Colon, pancreatic,
breast cancer
COMMONLY USED TUMOR MARKERS
The crucial link between anatomy and molecular pathways
From anatomy… via serological tumor markers … to molecular pathways
Lung KIT
Breast EGFR
ProstateHER2
Colon BRAF
BrainPIK3CA