Trust Your Gut: Data and Digital Tools for the Microbiome - An Emerging Field in Autoimmune Disease
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Transcript of Trust Your Gut: Data and Digital Tools for the Microbiome - An Emerging Field in Autoimmune Disease
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Trust Your Gut
Second Annual Targeting the Microbiome September 20-21, 2016 Bonnie Feldman DDS, MBA @DrBonnie360
Your Autoimmunity Connection
Data and Digital Tools for the Microbiome: An Emerging Field in Autoimmune Disease
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Trust Your Gut
+1.310.666.5312
www.drbonnie360.com
@DrBonnie360
www.facebook.com/YourAutoimmunityConnection
Bonnie Feldman, DDS, MBA DrBonnie360’s mission is to create a digitally connected world of personalized care for autoimmune patients. We consult with start-up companies and entrepreneurs who are bringing new products and services that will improve research, diagnosis, and treatment for autoimmunity
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The Road to Today
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2008
2012
2015
2016
The NIH Human Microbiome Project is established
Public Curiosity Ignites
Scientific American publishes an interactive human
microbiome infographic
Microbiome exhibit opens to the public
The Secret World Inside You
The White House announces the National Microbiome Intiative
Advances in research begin to
show connections to autoimmunity
@DrBonnie360
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AnInvisibleEpidemic
@DrBonnie360
~50 Million Americans have an autoimmune disease
DOUBLED
< 6% of NIH Funding goes to Autoimmunity
Source: http://bit.ly/1m0ttsl http://bit.ly/1B57pNb
incidence rate in children under 10 with IBD
in other words,
More than Cancer + Heart Disease combined
1 in 6 Americans Population of 25 states!
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Is Your Gut Fr iend or Foe?
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The Gut is Where
It’s At
Brain-Gut Axis
DOI:10.1038/nrn3346 @DrBonnie360
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DOI:10.1038/ajgsup.2012.4 @DrBonnie360
Location Matters
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Changing with Age
DOI:10.1038/nm.4142 @DrBonnie360
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Oral Diseases 26 APR 2016 DOI: 10.1111/odi.12472 http://onlinelibrary.wiley.com/doi/10.1111/odi.12472/full#odi12472-fig-0002
CLINICAL PRESENTATION
@DrBonnie360
Triggering Autoimmunity
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DOI:10.1038/ni.2611 @DrBonnie360
When Things
Go Wrong
The Leaky Gut
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The Leaky Gut in Celiac Disease
DOI:10.3390/nu7085314
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DOI:10.1038/nrgastro.2015.34 @DrBonnie360
A Life Balance
Inflammatory Bowel Disease
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DOI:10.1038/ajgsup.2012.4 @DrBonnie360
Diversity Matters
Inflammatory Bowel Disease
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DOI:10.1038/nrrheum.2011.121 @DrBonnie360
Beyond the Gut
Dysbiosis May Affect Other
Areas
Rheumatoid Arthritis
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Beyond the Gut
Dysbiosis &
Rheumatoid Arthritis
DOI:10.1038/nm.3916 @DrBonnie360
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Beyond the Gut
Dysbiosis &
Lupus
@DrBonnie360DOI:10.1128/mBio.01548-14
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Beyond the Gut Microbe Composition & Multiple Sclerosis
@DrBonnie360DOI:10.1038/ncomms12015
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DOI:10.1016/j.imlet.2014.08.017 @DrBonnie360
The Oral Microbiome
Dental Caries &
Periodontal Disease
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Caring for your Microbiome Your Personal Microbial Garden
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A
Tailor-Made
Personalizing Nutrition
DOI:10.111/nyas.13118 @DrBonnie360
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DOI:10.1016/j.cell.2015.11.001 @DrBonnie360
Tailor-Made
Personalizing Nutrition
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CompanyIndicaKonWhatHow
OpenBiome
TherapeuKc-Oral&
FecalTransplant
NonprofitStoolBank&ResearchPla5ormeliminatespracKcal
barrierstoFecalMicrobiotaTransplants(FMT)&provide
tailoredfecalmicrobiota
preparaKonstobioinformaKcs/
analyKcalservices
-DonorSelecKon;characterizewith
molecularbiomarkers,cross-secKonaldata,
&staKsKcaltoolstopredictwhichdonors
arewellsuited.
-MaintenanceTherapy;oralcapsulesto
deliver&explorelong-termmanagementof
chronicdiseases
uBiome CrowdsourcedDatabase Equipindividualswiththetools
neededtolearnaboutbacteria
withintheirbodies
-Sendsamplekits&surveystocollect
microbiomesforanalysis.
-UseNIHhumanmicrobiomeprojectto
sequenceDNA&IDeachstrain
-Comparewithlibrary&compileresults
Tailor-Made Global Crowdscience for the Microbiome
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DOI:10.1038/nbt.2548 @DrBonnie360
Tailor- Made
Medicines From
Microbiota
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CompanyIndicaKonWhatHow
AOBiome TherapeuKc-Topical
Skin
Advancethescienceof
AmmoniaOxidizingBacteria(AOB)torestoretheskin’s
microbiome
-TopicaltherapeuKc&consumer
productofAOBtoreintroduce
Nitrosomonastoskin’sbacterialflora&
restoreNitricOxidebalance
Enterome DiagnosKcs&
TherapeuKc
InflammatoryBowel
Disease-Crohn’s&
UlceraKveColiKs
QuanDtaDveMetagenomicsPla5orm(QMP)&FuncDonalMetagenomicsPla5orm(FMP)tosupport
personalizedmedicinefor
microbiome-relateddiseases
-QMPusestotalfecalbacterialgeneto
characterizepersonalmetagenome
withdiseasephenotype&ID
biomarkers
-FMPscreengenomic/metagenomic
librariesfordis&devofnewdrugs/
targets
MiomicsBio-
TherapeuKcs
TherapeuKc-Oral
Autoimmune
Disease-RA&MS
Oralbiologicalstorebalance
amicrobiotatowardsa
standardmicrobiota.
-ResearchGIinhabitancommensal
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CompanyIndicaKonWhatHow
Osel TherapeuKc-Topical
Women’sHealth
“LiveBiotherapeuDcProducts”(LBP)focusingonwomen’shealth(GU&GI)
-Libraryofproprietaryhumanbacterial
strains
-ScreeningmethodstoIDstrainsw/
uniqueprotecKveproperKes
-ProducestablehighqualityLBPfrom
selectedstrains
SecondGenome TherapeuKc-Oral
Crohn’sDisease
MicrobiomeModulaDngDiscoveryPla5orm(MMDP)
IDkeymicrobialcommunity
members/acKviKes/
metabolites&assayfor
modulatorypotenKalagainst
hosttargets
-Measure&IDchangesinthemicrobial
communitycomposiKon/funcKon/
signalinginhealthordiseasedstatesw/
MMDP
-GeneraKon&evalofsmallmolecules/
pepKdebiologic/bacterialstrainsthat
modulatemicrobe-microbeµbe-
humaninteracKons
SeresTherapeuKcs TherapeuKc-Topical
Dysbiosis,UlceraKve
ColiKs
PropritaryMicrobiomeTherapeuDcsPla5orm(PMTP)&EcobioDcdrugstoreestablishahealthy
microbiome
-ComputaKonalapproaches&PMTPto
IDorganismal/funcKonalnetworksof
microbialcommuniKes,&determine
whichorganismsworktogetherbest
withdiseasemicrobiometorestore
funcKon
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CompanyIndicaKonWhatHow
Synlogic TherapeuKc
RareGeneKc
MetabolicDisorders
&IBD
SyntheDcBioDcsengineeredprobioKcbacteria
-Plahormthatengineersnewmetabolic
funcKonintothemicrobiome
VedantaBiosciences TherapeuKc
Autoimmune
Modulatepathwaysof
interacKonbetweenhuman
microbiome&hostimmune
sys.Toinducetolerance&
restoreintesKnal
homeostasis
-Studymucosalimmunologyto
producedrugbasedonaproprietary
consorKaofpotentregulatoryTcell-
inducingClostridiumbacteria
WholeBiome
DiagnosKcs&
TherapeuKc
Metabolic
Syndrome
Proprietarydiscoverypla5ormfortargetedequilibraKonofthe
microbiome.Focuson
metabolicsyndrome
-TargetnovelsymbioKcfuncKonality
inherentinthehuman-microbial
interfacewithamicrobiomediagnosKc
discoveryplahorm
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• Autoimmune Disease: An Invisible Epidemic http://bit.ly/1m0ttsl
• The Serious Health Concern All 20-somethings Should Know About http://bit.ly/R9cEgp
• Decoding Autoimmunity – a Summary of the State of the Art http://bit.ly/1knzaAQ
• The Lonely Voices of Autoimmune Disease via Youtube http://bit.ly/X41mMv
• Believe It or Not – The Real Voices of Autoimmunity http://bit.ly/20xRCXO
Your Autoimmunity Exploration
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Exploring The Microbiome Lifeline
• Fasano, Alessio. “Leaky Gut and Autoimmune Diseases.” Clinical Reviews in Allergy & Immunology 42.1 (2012) : 71–8. <http://www.ncbi.nlm.nih.gov/pubmed/22109896>.
• Gomez, Andres, David Luckey, and Veena Taneja. “The Gut Microbiome in Autoimmunity: Sex Matters.”Clinical Immunology 159.2 (2015) : 154–162. <http://www.sciencedirect.com/science/article/pii/S1521661615001576>.
• Kamdar, K et al. “Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.” Cell Host & Microbe 19.1 (2016) : 21-31. <http://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(15)00498-9>.
• McLean, Mairi et al. “Does the Microbiota Play a Role in the Pathogenesis of Autoimmune Diseases?” Gut
64.2 (2014) : gutjnl–2014–308514. <http://gut.bmj.com/content/early/2014/11/28/gutjnl-2014-308514>.
• Waldor, Matthew et al. “Where next for Microbiome Research?” PLoS Biology 13.1 (2015) : e1002050. <http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050>.
• Wu, Hao, Valentina Tremaroli, and Fredrik Bäckhed. “Linking Microbiota to Human Diseases: A Systems Biology Perspective.” Trends in Endocrinology & Metabolism 26.12 (2015) : 758-770. <http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00194-0>.
Autoimmunity and the Microbiome
@DrBonnie360
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The Microbiome and Inflammatory Bowel Disease
• De Souza, Heitor, and Claudio Fiocchi. “Immunopathogenesis of IBD: Current State of the Art.” Nature Reviews Gastroenterology & Hepatology (2015) : 13-27 <http://www.ncbi.nlm.nih.gov/pubmed/26627550>.
• Sartor, R. Balfour. “The Intestinal Microbiota in Inflammatory Bowel Disease.” Nestle Nutrition Institute Workshop Series 79 (2014) : 29–39.<https://uncch.pure.elsevier.com/en/publications/the-intestinal-microbiota-in-inflammatory-bowel-diseases>.
• Sartor, RB, and SK Mazmanian. “Intestinal Microbes in Inflammatory Bowel Diseases.” The
American Journal of Gastroenterology … (2012) : 15-21. <http://www.nature.com/ajgsup/journal/v1/n1/abs/ajgsup20124a.html>.
• Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases.” Cell Host & Microbe 17.5 (2015) : 577-591. <http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00166-3>.
@DrBonnie360
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The Microbiome and Periodontal Disease
• Costalonga, M, and MC Herzberg. “The Oral Microbiome and the Immunobiology of Periodontal Disease and Caries.” Immunology Letters 162.2 (2014) : 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>.
Rheumatoid Arthritis
Systemic Lupus Erythematosus
• Scher, JU, and SB Abramson. “The Microbiome and Rheumatoid Arthritis.” Nature Reviews Rheumatology 7 (2011) : 569-578. <http://www.nature.com/nrrheum/journal/v7/n10/abs/nrrheum.2011.121.html>.
• Mu, Q, H Zhang, and XM Luo. “SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?” Frontiers in Immunology (2015) : n. pag. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/>.
@DrBonnie360
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Prevention – Diet, Food, & Nutrition
• Tilg, H, and AR Moschen. “Food, Immunity, and the Microbiome.” Gastroenterology 148.6 (2015) : 1107-1119. <http://www.sciencedirect.com/science/article/pii/S0016508515000128>.
• Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell. 163.5 (2015) : 1079-1094. <http://www.cell.com/abstract/S0092-8674(15)01481-6>.
• Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human Microbiome in Health and Disease.” Cell Host & Microbe 19.1 (2016) : 12-20. <http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>.
Prevention – Prebiotics & Probiotics
• Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology. (2012) : 39-51. <http://tag.sagepub.com/content/early/2012/09/24/1756283X12459294.abstract>.
• Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of Translation.” Annals of the New York Academy of Sciences (2013) : 1-17. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full>.
@DrBonnie360
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• 2008=HumanMicrobiomeProject.hlp://hmpdacc.org/overview/about.php
• 2012=ScienKficAmerican,explorethehumanmicrobiome(interacKve)hlp://www.scienKficamerican.com/arKcle/microbiome-graphic-
explore-human-microbiome/
• 2015=AmericanMuseumofNaturalHistory
• exhibit:TheSecretWorldInsideYouhlp://www.amnh.org/calendar/the-secret-world-inside-you
• info:MeetyourMicrobiomehlp://www.amnh.org/explore/science-topics/health-and-our-microbiome/meet-your-microbiome
• 2016=hlps://www.whitehouse.gov/the-press-office/2016/05/12/fact-sheet-announcing-naKonal-microbiome-iniKaKve