TRP Channel - MedchemExpress.com · TRP channels are important for human health as mutations in at...
Transcript of TRP Channel - MedchemExpress.com · TRP channels are important for human health as mutations in at...
TRP ChannelTransient receptor potential channels
TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane ofnumerous human and animal cell types There are about 28 TRP channels that share some structural similarity to each other Theseare grouped into two broad groups Group 1 includes TRPC (C for canonical) TRPV (V for vanilloid) TRPM (M for melastatin)TRPN and TRPA In group 2 there are TRPP (P for polycystic) and TRPML (ML for mucolipin) Many of these channels mediate avariety of sensations like the sensations of pain hotness warmth or coldness different kinds of tastes pressure and vision TRPchannels are relatively non-selectively permeable to cations including sodium calcium and magnesium TRP channels are initiallydiscovered in trp-mutant strain of the fruit fly Drosophila Later TRP channels are found in vertebrates where they are ubiquitouslyexpressed in many cell types and tissues TRP channels are important for human health as mutations in at least four TRP channelsunderlie disease
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TRP Channel Antagonists Inhibitors Agonists Activators amp Modulators
(-)-MentholCat No HY-75161
(-)-Menthol is a key component of peppermint oilthat binds and activates transient receptorpotential melastatin 8 ( ) aTRPM8Ca -permeable nonselective cation channel to2+
increase [Ca ] Antitumor activity2+i
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g
(E)-Cardamonin ((E)-Cardamomin (E)-Alpinetin chalcone) Cat No HY-N1378
(E)-Cardamonin ((E)-Cardamomin) is a novelantagonist of cation channel with an hTRPA1 IC50
of 454 nM
Purity 9981Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
(Z)-Capsaicin (Zucapsaicin Civamide cis-Capsaicin) Cat No HY-B1583
(Z)-Capsaicin is the cis isomer of capsaicin actsas an orally active agonist and is used inTRPV1the research of neuropathic pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
14-CineoleCat No HY-N7117
14-Cineole is a widely distributed naturaloxygenated monoterpene 14-Cineole present ineucalyptus oil activates both human andTRPM8human TRPA1
Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
2-Aminoethyl diphenylborinate (2-APB) Cat No HY-W009724
2-Aminoethyl diphenylborinate (2-APB) is acell-permeable inhibitor of 2-AminoethylIP3Rdiphenylborinate also inhibits the store-operated
channel and activates some Ca (SOC)2+ TRPchannels (V1 V2 and V3)
Purity 9803Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
8-GingerolCat No HY-N0447
8-Gingerol found in the rhizomes of ginger (Z) with oral bioavailability activatesofficinale
with an EC of 50 microM 8-GingerolTRPV1 50
inhibits COX-2 and inhibits the growth of H pyloriin vitro
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
A-1165442Cat No HY-12428
A-1165442 is a potent competitive and orallyavailable antagonist with an of 9 nMTRPV1 IC50
for human TRPV1
Purity 9970Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg 100 mg
A-967079Cat No HY-108463
A-967079 is a selective receptor antagonistTRPA1with s of 67 nM and 289 nM at human and ratIC50
TRPA1 receptors respectively and has goodpenetration into the CNS
Purity 9866Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
ABT-239Cat No HY-12195
ABT-239 is a novel highly efficaciousnon-imidazole class of antagonist and aH3Rtransient receptor potential vanilloid type 1( ) antagonist TRPV1
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Adenosine 5prime-diphosphoribose sodium (ADP ribose sodium) Cat No HY-100973A
Adenosine 5prime-diphosphoribose sodium (ADP ribosesodium) is a nicotinamide adenine nucleotide(NAD ) metabolite Adenosine 5prime-diphosphoribose+
sodium is the most potent and primaryintracellular Ca -permeable cation 2+ TRPM2
activatorchannel
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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AM-0902Cat No HY-108329
AM-0902 is a potent selective transient receptorpotential A1 ( ) antagonist with s of 71TRPA1 IC50
and 131 nM for and respectivelyrTRPA1 hTRPA1
Purity 9967Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
AM12Cat No HY-128561
AM12 inhibits Lanthanide-evoked activityTRPC5with an of 028 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AMG 333Cat No HY-112703
AMG 333 is a potent and highly selective TRPM8antagonist with an of 13 nMIC50
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
AMG 517Cat No HY-10634
AMG 517 is a potent and selective vanilloidreceptor-1 ( ) antagonist with an of 05TRPV1 IC50
nM
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
AMG2850Cat No HY-104059
AMG2850 is a potent orally bioavailable andselective transient receptor potential melastatin 8
antagonist(TRPM8)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AMG9810Cat No HY-101736
AMG9810 is a selective and competitive vanilloidreceptor 1 ( ) antagonist with values ofTRPV1 IC50
245 and 856 nM for human and rat TRPV1repectively
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Amiloride (MK-870) Cat No HY-B0285
Amiloride (MK-870) is an inhibitor of bothepithelial sodium channel ( ) andENaCurokinase-type plasminogen activator receptor( ) Amiloride is a blocker of uTPA polycystin-2(PC2 ) channelTRPP2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Amiloride hydrochloride (MK-870 hydrochloride) Cat No HY-B0285A
Amiloride hydrochloride (MK-870 hydrochloride) isan inhibitor of both epithelial sodium channel( ) and urokinase-type plasminogen activatorENaCreceptor ( ) Amiloride hydrochloride is auTPAblocker of (PC2 ) channelpolycystin-2 TRPP2
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) Cat No HY-B0285B
Amiloride hydrochloride dihydrate (MK-870hydrochloride dihydrate) is an inhibitor of bothepithelial sodium channel ( ) andENaCurokinase-type plasminogen activator receptor( ) Amiloride hydrochloride dihydrate is auTPAblocker of (PC2 ) channelpolycystin-2 TRPP2
Purity 9856Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Asivatrep (PAC-14028) Cat No HY-12777
Asivatrep (PAC-14028) is a potent and selectivetransient receptor potential vanilloid type I( ) antagonistTRPV1
Purity 9514Clinical Data Phase 3Size 10 mM times 1 mL 1 mg 5 mg 10 mg 50 mg 100 mg
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ASP7663Cat No HY-101907
ASP7663 is an orally active and selective TRPA1agonist ASP7663 exerts both anti-constipation andanti-abdominal pain actions
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
BCTCCat No HY-19960
BCTC is a potent and specific inhibitor oftransient receptor potential cation channelsubfamily M member 8 (TRPM8) in prostate cancer(PCa) DU145 cells
Purity 9723Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Beta-EudesmolCat No HY-N6018
Beta-Eudesmol is a natural oxygenatedsesquiterpene activates with an hTRPA1 EC50
of 325 μM Beta-Eudesmol increases appetitethrough TRPA1
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
BI-749327Cat No HY-111925
BI-749327 is a potent high selectivity and orallybioavailable antagonist with s of 13TRPC6 IC50
nM 19 nM and 15 nM for mouse human and guineapig TRPC6 respectively BI-749327 is 85-fold moreselective for mouse TRPC6 than TRPC3 and 42-foldversus TRPC7
Purity 9953Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Bisandrographolide CCat No HY-N2941
Bisandrographolide C is an unusual dimer ofent-labdane diterpenoid isolated and identifiedfrom Andrographis paniculata
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Caffeic acidCat No HY-N0172
Caffeic acid is an inhibitor of both ionTRPV1channel and ( )5-Lipoxygenase 5-LO
Purity 9880Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 5 g
Camphor ((plusmn)-Camphor) Cat No HY-N0808
Camphor ((plusmn)-Camphor) is a topical anti-infectiveand anti-pruritic and internally as a stimulantand carminative However Camphor is poisonouswhen ingested Antiviral antitussive andanticancer activities Camphor is a TRPV3agonist
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Capsaicin ((E)-Capsaicin) Cat No HY-10448
Capsaicin ((E)-Capsaicin) is a mixture ofCapsaicin and Dihydrocapsaicin Capsaici is a
agonist with an of 029 μM in HEK293TRPV1 EC50
cells
Purity 9901Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
CapsazepineCat No HY-15640
Capsazepine is a synthetic analogue of the sensoryneurone excitotoxin and an antagonist of TRPV1
with an of 562 nMreceptor IC50
Purity 9917Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Chembridge-5861528 (TCS 5861528) Cat No HY-15065
Chembridge-5861528 is a TRPA1 channel blocker thatantagonizes AITC- and 4-HNE-evoked calcium influx(IC50 values are 143 and 187μM respectively)
Purity 9704Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Cyclic ADP-ribose (cADPR) Cat No HY-N7395
Cyclic ADP-ribose (cADPR) is a potent secondmessenger for that iscalcium mobilizationsynthesized from NAD by a ADP-ribosyl cyclase+
Purity gt98Clinical Data No Development ReportedSize 500 μg
D-3263Cat No HY-16162
D-3263 is an agonist of transient receptorpotential melastatin member 8 ( ) withTRPM8potential antineoplastic activity
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
D-3263 hydrochlorideCat No HY-16162A
D-3263 hydrochloride is an enteric-coated orallybioavailable (transient receptor potentialmelastatin member 8) agonistTRPM8
Purity 9801Clinical Data Phase 1Size 10 mM times 1 mL 1 mg 5 mg 10 mg 50 mg 100 mg
DihydrocapsaicinCat No HY-N0361
Dihydrocapsaicin is a natural capsaicin acts as aselective agonist and also increases p-AktTRPV1levels Dihydrocapsaicin enhances thehypothermia-induced neuroprotection
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Diphenyleneiodonium chloride (DPI) Cat No HY-100965
Diphenyleneiodonium chloride is a NADPH oxidase( ) inhibitor and also functions as a NOX TRPA1activator with an of 1 to 3 μMEC50
Diphenyleneiodonium chloride selectively inhibitsintracellular reactive oxygen species
Purity 9987Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
DS88790512Cat No HY-112298
DS88790512 is a potent selective and orallybioavailable inhibitor with an of 11TRPC6 IC50
nM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
EIPA (L593754 MH 12-43) Cat No HY-101840
EIPA (L593754) is a inhibitor withTRPP3 channelan of 105 μM EIPA also inhibitsIC50
( ) andNa H -exchanger+ + NHEmacropinocytosis
Purity 9973Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
EIPA hydrochloride (L593754 hydrochloride MH 12-43 hydrochloride) Cat No HY-101840A
EIPA hydrochloride (L593754 hydrochloride) is a inhibitor with an of 105 μMTRPP3 channel IC50
EIPA hydrochloride also inhibits ( ) andNa H -exchanger+ + NHE
macropinocytosis
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GFB-8438Cat No HY-133012
GFB-8438 is a potent and subtype selective TRPC5inhibitor with s of 018 and 029 μM ofIC50
hTRPC5 and hTRPC4 respectively GFB-8438 showsexcellent selectivity against TRPC6 other TRPfamily members NaV 15 as well as limitedactivity against the hERG channel
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
GSK1016790ACat No HY-19608
GSK1016790A is a potent transient receptorpotential vanilloid 4 ( ) activatorTRPV4
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
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GSK1702934ACat No HY-111098
GSK1702934A is a selective agonistTRPC3GSK1702934A modulates cardiac contractility and farrhythmogenesis by activation of TRPC3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GSK205Cat No HY-120691A
GSK205 is a potent selective antagonistTRPV4with an of 419 μM for inhibitingIC50
-mediated Ca influxTRPV4 2+
Purity 9945Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2193874Cat No HY-100720
GSK2193874 is an orally active potent andselective antagonist with s of 2 nM andTRPV4 IC50
40 nM for and rTRPV4 hTRPV4
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2798745Cat No HY-19765
GSK2798745 is a first-in-class highly potentselective orally active transient receptorpotential vanilloid 4 blocker(TRPV4) ion channelwith s of 18 and 16 nM for hTRPV4 andIC50
rTRPV4 respectively
Purity 9827Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg
GSK3395879Cat No HY-112202
GSK3395879 is a selective and orally bioavailabletransient receptor potential vanilloid-4 ( )TRPV4antagonist with an of 1 nM for hTRPV4IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
HC-030031Cat No HY-15064
HC-030031 is a potent and selective TRPA1inhibitor which antagonizes AITC- andformalin-evoked calcium influx with s ofIC50
62plusmn02 and 53plusmn02 μM respectively
Purity 9591Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
HC-067047Cat No HY-100208
HC-067047 is a potent and selective TRPV4antagonist and reversibly inhibits currentsthrough the human rat and mouse orthologsTRPV4with values of 48 nM 133 nM and 17 nMIC50
respectively
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
HC-070Cat No HY-112302
HC-070 is an antagonist of withTRPC4TRPC5s of 93 nM and 46 nM for hTRPC5 and hTRPC4 inIC50
cells respectively
Purity 9823Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Hydroxy-α-sanshoolCat No HY-N6825
Hydroxy-α-sanshool is an alkylamide isolatedfrom acts as a covalent and pepper TRPA1 TRPV1non-covalent agonist with s of 69 and 11EC50
microM respectively
Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) Cat No HY-116330A
Hyperforin dicyclohexylammonium salt (HyperforinDCHA) is a transient receptor canonical 6 (TRPC6)channels activator Hyperforindicyclohexylammonium salt modulates Ca levels2+
by activating Ca -conducting non-selective2+
canonical TRPC6 channels
Purity 9817Clinical Data No Development ReportedSize 500 μg 1 mg
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IA-Alkyne (Iodoacetamide-alkyne N-Hex-5-ynyl-2-iodo-acetamide) Cat No HY-136205
IA-Alkyne (Iodoacetamide-alkyneN-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel
agonist and has the potential for the(TRPC)study of respiratory infection IA-Alkyne can beused to develop an isotopically tagged forprobequantitative profilingcysteine-reactivity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Icilin (AG-3-5) Cat No HY-11062
Icilin(AG 3-5) is a synthetic super-agonist ofTRPM8 ion channel
Purity gt960Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Imperatorin (Ammidin) Cat No HY-N0285
Imperatorin is an effective of NO synthesisinhibitor ( =92 μmol) which also is a IC50 BChEinhibitor ( =314 μmol) Imperatorin is a weakIC50
agonist of with of 126plusmn32 μMTRPV1 EC50
Purity 9581Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
JNJ-17203212Cat No HY-100129
JNJ-17203212 is a novel and selective TRPV1antagonist with IC50 of 65 nM and 102 nM forhuman TRPV1 and rat TRPV1
Purity 9994Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
JT010Cat No HY-111132
JT010 is a potent agonist of with an TRPA1 EC50
of 065 nM
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
JYL 1421 (SC 0030) Cat No HY-100668
JYL 1421 is a antagonist with anTRPV1 receptor of 8 nMIC50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
Linopirdine (DuP 996) Cat No HY-W020468
Linopirdine (DuP 996) is an orally activeselective M-type K current (IM Kv7 KCNQ+
inhibitor with an of 24 μMChannels) IC50
Linopirdine is a agonist Linopirdine aTRPV1putative cognition enhancing drug increasesacetylcholine release in rat brain tissue
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mavatrep (JNJ-39439335) Cat No HY-16935
Mavatrep is an orally bioavailable TRPV1antagonist (Ki=65 nM) exhibits minimal effect onthe enzymatic activity (IC50 gt 25 μM) of CYPisoforms 3A4 1A2 and 2D6
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
MDR-652Cat No HY-136363
MDR-652 is a highly specific and efficacious ( )transient receptor potential vanilloid 1 TRPV1
ligand with agonist activity The s are 114 andKi
238 nM for hTRPV1 and rTRPV1 respectively Thes are 505 and 93 nM for hTRPV1 and rTRPV1EC50
respectively Potent topical analgesic activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Methyl syringateCat No HY-W002116
Methyl syringate a chemical marker of asphodelmonofloral honey is an efficient phenolicmediator for bacterial and fungal laccases Methylsyringate is a agonistTRPA1
Purity 9976Clinical Data No Development ReportedSize 100 mg
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Mifamurtide (MTP-PE L-MTP-PE CGP 19835) Cat No HY-13682
Mifamurtide (MTP-PE CGP19835) is a drug againstosteosarcoma Mifamurtide is an immunomodulatorwith antitumor effects that appear to be mediatedvia activation of monocytes and macrophages
Purity gt990Clinical Data LaunchedSize 1 mg 5 mg 10 mg
MK6-83Cat No HY-110238
MK6-83 is a new candidate agonist of TRPML1with an improved efficacy and potency MK6-83 hasthe potential for Mucolipidosis type IV study
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
ML204Cat No HY-12949
ML204 is a novel potent antagonist thatselectively modulates native TRPC4C5 ionchannels
Purity 9831Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
ML204 hydrochlorideCat No HY-12949A
ML204 hydrochloride is a novel potent selectiveTRPC4 channel inhibitor with IC50 of 096 uMexhibit 19-fold selectivity against TRPC6 channelsin similar fluorescent assays target ML204 IC50096 uM In vitro ML204 inhibited TRPC4β-mediatedintracellular Ca2+ rise
Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) Cat No HY-118628
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is abroad spectrum inhibitorPhospholipase A (PLA )2 2
and blockerTRP channel
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Nonivamide (Pelargonic acid vanillylamide Nonanoic acid
vanillylamide Pseudocapsaicin) Cat No HY-17568
Nonivamide is a ltbltTRPV1 agonist whichexhibits 4d- value of 51 mgL in staticEC50
toxicity tests
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 5 g
OMDM-5Cat No HY-135881
OMDM-5 is a selective inhibitor of anandamide with a of 48 μMcellular uptake (ACU) Ki
OMDM-5 is also a potent vanilloid receptor type 1 agonist with an of 75 nM(VR1 TRPV1) EC50
and shows weakly active as cannabinoid receptortype 1 (CB1) ligand (K =49 μM)i
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OMDM-6Cat No HY-135882
OMDM-6 is a hybrid agonist of vanilloid receptor ( =75 nM) and type 1 (VR1 TRPV1) EC50 cannabinoid
( =32 μM) OMDM-6receptor type 1 (CB1) Ki
inhibits withanandamide cellular uptake (ACU)a of 70 μMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OptovinCat No HY-12809
Optovin is a reversible photoactive TRPA1activator stimulates human TRPA1 channels invitro and enables repeated photoactivation ofmotor behaviors in wild-type zebrafish (EC50 = 2μM)
Purity 9954Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
PF-04745637Cat No HY-120689
PF-04745637 is a potent and selective TRPA1antagonist with an of 17 nM for human TRPA1IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
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Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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TRP Channel Antagonists Inhibitors Agonists Activators amp Modulators
(-)-MentholCat No HY-75161
(-)-Menthol is a key component of peppermint oilthat binds and activates transient receptorpotential melastatin 8 ( ) aTRPM8Ca -permeable nonselective cation channel to2+
increase [Ca ] Antitumor activity2+i
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g
(E)-Cardamonin ((E)-Cardamomin (E)-Alpinetin chalcone) Cat No HY-N1378
(E)-Cardamonin ((E)-Cardamomin) is a novelantagonist of cation channel with an hTRPA1 IC50
of 454 nM
Purity 9981Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
(Z)-Capsaicin (Zucapsaicin Civamide cis-Capsaicin) Cat No HY-B1583
(Z)-Capsaicin is the cis isomer of capsaicin actsas an orally active agonist and is used inTRPV1the research of neuropathic pain
Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg
14-CineoleCat No HY-N7117
14-Cineole is a widely distributed naturaloxygenated monoterpene 14-Cineole present ineucalyptus oil activates both human andTRPM8human TRPA1
Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg
2-Aminoethyl diphenylborinate (2-APB) Cat No HY-W009724
2-Aminoethyl diphenylborinate (2-APB) is acell-permeable inhibitor of 2-AminoethylIP3Rdiphenylborinate also inhibits the store-operated
channel and activates some Ca (SOC)2+ TRPchannels (V1 V2 and V3)
Purity 9803Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg
8-GingerolCat No HY-N0447
8-Gingerol found in the rhizomes of ginger (Z) with oral bioavailability activatesofficinale
with an EC of 50 microM 8-GingerolTRPV1 50
inhibits COX-2 and inhibits the growth of H pyloriin vitro
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg
A-1165442Cat No HY-12428
A-1165442 is a potent competitive and orallyavailable antagonist with an of 9 nMTRPV1 IC50
for human TRPV1
Purity 9970Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg 100 mg
A-967079Cat No HY-108463
A-967079 is a selective receptor antagonistTRPA1with s of 67 nM and 289 nM at human and ratIC50
TRPA1 receptors respectively and has goodpenetration into the CNS
Purity 9866Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
ABT-239Cat No HY-12195
ABT-239 is a novel highly efficaciousnon-imidazole class of antagonist and aH3Rtransient receptor potential vanilloid type 1( ) antagonist TRPV1
Purity 9906Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Adenosine 5prime-diphosphoribose sodium (ADP ribose sodium) Cat No HY-100973A
Adenosine 5prime-diphosphoribose sodium (ADP ribosesodium) is a nicotinamide adenine nucleotide(NAD ) metabolite Adenosine 5prime-diphosphoribose+
sodium is the most potent and primaryintracellular Ca -permeable cation 2+ TRPM2
activatorchannel
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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AM-0902Cat No HY-108329
AM-0902 is a potent selective transient receptorpotential A1 ( ) antagonist with s of 71TRPA1 IC50
and 131 nM for and respectivelyrTRPA1 hTRPA1
Purity 9967Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
AM12Cat No HY-128561
AM12 inhibits Lanthanide-evoked activityTRPC5with an of 028 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AMG 333Cat No HY-112703
AMG 333 is a potent and highly selective TRPM8antagonist with an of 13 nMIC50
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
AMG 517Cat No HY-10634
AMG 517 is a potent and selective vanilloidreceptor-1 ( ) antagonist with an of 05TRPV1 IC50
nM
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
AMG2850Cat No HY-104059
AMG2850 is a potent orally bioavailable andselective transient receptor potential melastatin 8
antagonist(TRPM8)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AMG9810Cat No HY-101736
AMG9810 is a selective and competitive vanilloidreceptor 1 ( ) antagonist with values ofTRPV1 IC50
245 and 856 nM for human and rat TRPV1repectively
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Amiloride (MK-870) Cat No HY-B0285
Amiloride (MK-870) is an inhibitor of bothepithelial sodium channel ( ) andENaCurokinase-type plasminogen activator receptor( ) Amiloride is a blocker of uTPA polycystin-2(PC2 ) channelTRPP2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Amiloride hydrochloride (MK-870 hydrochloride) Cat No HY-B0285A
Amiloride hydrochloride (MK-870 hydrochloride) isan inhibitor of both epithelial sodium channel( ) and urokinase-type plasminogen activatorENaCreceptor ( ) Amiloride hydrochloride is auTPAblocker of (PC2 ) channelpolycystin-2 TRPP2
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) Cat No HY-B0285B
Amiloride hydrochloride dihydrate (MK-870hydrochloride dihydrate) is an inhibitor of bothepithelial sodium channel ( ) andENaCurokinase-type plasminogen activator receptor( ) Amiloride hydrochloride dihydrate is auTPAblocker of (PC2 ) channelpolycystin-2 TRPP2
Purity 9856Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Asivatrep (PAC-14028) Cat No HY-12777
Asivatrep (PAC-14028) is a potent and selectivetransient receptor potential vanilloid type I( ) antagonistTRPV1
Purity 9514Clinical Data Phase 3Size 10 mM times 1 mL 1 mg 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 3
ASP7663Cat No HY-101907
ASP7663 is an orally active and selective TRPA1agonist ASP7663 exerts both anti-constipation andanti-abdominal pain actions
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
BCTCCat No HY-19960
BCTC is a potent and specific inhibitor oftransient receptor potential cation channelsubfamily M member 8 (TRPM8) in prostate cancer(PCa) DU145 cells
Purity 9723Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Beta-EudesmolCat No HY-N6018
Beta-Eudesmol is a natural oxygenatedsesquiterpene activates with an hTRPA1 EC50
of 325 μM Beta-Eudesmol increases appetitethrough TRPA1
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
BI-749327Cat No HY-111925
BI-749327 is a potent high selectivity and orallybioavailable antagonist with s of 13TRPC6 IC50
nM 19 nM and 15 nM for mouse human and guineapig TRPC6 respectively BI-749327 is 85-fold moreselective for mouse TRPC6 than TRPC3 and 42-foldversus TRPC7
Purity 9953Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Bisandrographolide CCat No HY-N2941
Bisandrographolide C is an unusual dimer ofent-labdane diterpenoid isolated and identifiedfrom Andrographis paniculata
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Caffeic acidCat No HY-N0172
Caffeic acid is an inhibitor of both ionTRPV1channel and ( )5-Lipoxygenase 5-LO
Purity 9880Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 5 g
Camphor ((plusmn)-Camphor) Cat No HY-N0808
Camphor ((plusmn)-Camphor) is a topical anti-infectiveand anti-pruritic and internally as a stimulantand carminative However Camphor is poisonouswhen ingested Antiviral antitussive andanticancer activities Camphor is a TRPV3agonist
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Capsaicin ((E)-Capsaicin) Cat No HY-10448
Capsaicin ((E)-Capsaicin) is a mixture ofCapsaicin and Dihydrocapsaicin Capsaici is a
agonist with an of 029 μM in HEK293TRPV1 EC50
cells
Purity 9901Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
CapsazepineCat No HY-15640
Capsazepine is a synthetic analogue of the sensoryneurone excitotoxin and an antagonist of TRPV1
with an of 562 nMreceptor IC50
Purity 9917Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Chembridge-5861528 (TCS 5861528) Cat No HY-15065
Chembridge-5861528 is a TRPA1 channel blocker thatantagonizes AITC- and 4-HNE-evoked calcium influx(IC50 values are 143 and 187μM respectively)
Purity 9704Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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Cyclic ADP-ribose (cADPR) Cat No HY-N7395
Cyclic ADP-ribose (cADPR) is a potent secondmessenger for that iscalcium mobilizationsynthesized from NAD by a ADP-ribosyl cyclase+
Purity gt98Clinical Data No Development ReportedSize 500 μg
D-3263Cat No HY-16162
D-3263 is an agonist of transient receptorpotential melastatin member 8 ( ) withTRPM8potential antineoplastic activity
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
D-3263 hydrochlorideCat No HY-16162A
D-3263 hydrochloride is an enteric-coated orallybioavailable (transient receptor potentialmelastatin member 8) agonistTRPM8
Purity 9801Clinical Data Phase 1Size 10 mM times 1 mL 1 mg 5 mg 10 mg 50 mg 100 mg
DihydrocapsaicinCat No HY-N0361
Dihydrocapsaicin is a natural capsaicin acts as aselective agonist and also increases p-AktTRPV1levels Dihydrocapsaicin enhances thehypothermia-induced neuroprotection
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Diphenyleneiodonium chloride (DPI) Cat No HY-100965
Diphenyleneiodonium chloride is a NADPH oxidase( ) inhibitor and also functions as a NOX TRPA1activator with an of 1 to 3 μMEC50
Diphenyleneiodonium chloride selectively inhibitsintracellular reactive oxygen species
Purity 9987Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
DS88790512Cat No HY-112298
DS88790512 is a potent selective and orallybioavailable inhibitor with an of 11TRPC6 IC50
nM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
EIPA (L593754 MH 12-43) Cat No HY-101840
EIPA (L593754) is a inhibitor withTRPP3 channelan of 105 μM EIPA also inhibitsIC50
( ) andNa H -exchanger+ + NHEmacropinocytosis
Purity 9973Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
EIPA hydrochloride (L593754 hydrochloride MH 12-43 hydrochloride) Cat No HY-101840A
EIPA hydrochloride (L593754 hydrochloride) is a inhibitor with an of 105 μMTRPP3 channel IC50
EIPA hydrochloride also inhibits ( ) andNa H -exchanger+ + NHE
macropinocytosis
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GFB-8438Cat No HY-133012
GFB-8438 is a potent and subtype selective TRPC5inhibitor with s of 018 and 029 μM ofIC50
hTRPC5 and hTRPC4 respectively GFB-8438 showsexcellent selectivity against TRPC6 other TRPfamily members NaV 15 as well as limitedactivity against the hERG channel
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
GSK1016790ACat No HY-19608
GSK1016790A is a potent transient receptorpotential vanilloid 4 ( ) activatorTRPV4
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 5
GSK1702934ACat No HY-111098
GSK1702934A is a selective agonistTRPC3GSK1702934A modulates cardiac contractility and farrhythmogenesis by activation of TRPC3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GSK205Cat No HY-120691A
GSK205 is a potent selective antagonistTRPV4with an of 419 μM for inhibitingIC50
-mediated Ca influxTRPV4 2+
Purity 9945Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2193874Cat No HY-100720
GSK2193874 is an orally active potent andselective antagonist with s of 2 nM andTRPV4 IC50
40 nM for and rTRPV4 hTRPV4
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2798745Cat No HY-19765
GSK2798745 is a first-in-class highly potentselective orally active transient receptorpotential vanilloid 4 blocker(TRPV4) ion channelwith s of 18 and 16 nM for hTRPV4 andIC50
rTRPV4 respectively
Purity 9827Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg
GSK3395879Cat No HY-112202
GSK3395879 is a selective and orally bioavailabletransient receptor potential vanilloid-4 ( )TRPV4antagonist with an of 1 nM for hTRPV4IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
HC-030031Cat No HY-15064
HC-030031 is a potent and selective TRPA1inhibitor which antagonizes AITC- andformalin-evoked calcium influx with s ofIC50
62plusmn02 and 53plusmn02 μM respectively
Purity 9591Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
HC-067047Cat No HY-100208
HC-067047 is a potent and selective TRPV4antagonist and reversibly inhibits currentsthrough the human rat and mouse orthologsTRPV4with values of 48 nM 133 nM and 17 nMIC50
respectively
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
HC-070Cat No HY-112302
HC-070 is an antagonist of withTRPC4TRPC5s of 93 nM and 46 nM for hTRPC5 and hTRPC4 inIC50
cells respectively
Purity 9823Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Hydroxy-α-sanshoolCat No HY-N6825
Hydroxy-α-sanshool is an alkylamide isolatedfrom acts as a covalent and pepper TRPA1 TRPV1non-covalent agonist with s of 69 and 11EC50
microM respectively
Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) Cat No HY-116330A
Hyperforin dicyclohexylammonium salt (HyperforinDCHA) is a transient receptor canonical 6 (TRPC6)channels activator Hyperforindicyclohexylammonium salt modulates Ca levels2+
by activating Ca -conducting non-selective2+
canonical TRPC6 channels
Purity 9817Clinical Data No Development ReportedSize 500 μg 1 mg
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IA-Alkyne (Iodoacetamide-alkyne N-Hex-5-ynyl-2-iodo-acetamide) Cat No HY-136205
IA-Alkyne (Iodoacetamide-alkyneN-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel
agonist and has the potential for the(TRPC)study of respiratory infection IA-Alkyne can beused to develop an isotopically tagged forprobequantitative profilingcysteine-reactivity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Icilin (AG-3-5) Cat No HY-11062
Icilin(AG 3-5) is a synthetic super-agonist ofTRPM8 ion channel
Purity gt960Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Imperatorin (Ammidin) Cat No HY-N0285
Imperatorin is an effective of NO synthesisinhibitor ( =92 μmol) which also is a IC50 BChEinhibitor ( =314 μmol) Imperatorin is a weakIC50
agonist of with of 126plusmn32 μMTRPV1 EC50
Purity 9581Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
JNJ-17203212Cat No HY-100129
JNJ-17203212 is a novel and selective TRPV1antagonist with IC50 of 65 nM and 102 nM forhuman TRPV1 and rat TRPV1
Purity 9994Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
JT010Cat No HY-111132
JT010 is a potent agonist of with an TRPA1 EC50
of 065 nM
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
JYL 1421 (SC 0030) Cat No HY-100668
JYL 1421 is a antagonist with anTRPV1 receptor of 8 nMIC50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
Linopirdine (DuP 996) Cat No HY-W020468
Linopirdine (DuP 996) is an orally activeselective M-type K current (IM Kv7 KCNQ+
inhibitor with an of 24 μMChannels) IC50
Linopirdine is a agonist Linopirdine aTRPV1putative cognition enhancing drug increasesacetylcholine release in rat brain tissue
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mavatrep (JNJ-39439335) Cat No HY-16935
Mavatrep is an orally bioavailable TRPV1antagonist (Ki=65 nM) exhibits minimal effect onthe enzymatic activity (IC50 gt 25 μM) of CYPisoforms 3A4 1A2 and 2D6
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
MDR-652Cat No HY-136363
MDR-652 is a highly specific and efficacious ( )transient receptor potential vanilloid 1 TRPV1
ligand with agonist activity The s are 114 andKi
238 nM for hTRPV1 and rTRPV1 respectively Thes are 505 and 93 nM for hTRPV1 and rTRPV1EC50
respectively Potent topical analgesic activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Methyl syringateCat No HY-W002116
Methyl syringate a chemical marker of asphodelmonofloral honey is an efficient phenolicmediator for bacterial and fungal laccases Methylsyringate is a agonistTRPA1
Purity 9976Clinical Data No Development ReportedSize 100 mg
wwwMedChemExpresscom 7
Mifamurtide (MTP-PE L-MTP-PE CGP 19835) Cat No HY-13682
Mifamurtide (MTP-PE CGP19835) is a drug againstosteosarcoma Mifamurtide is an immunomodulatorwith antitumor effects that appear to be mediatedvia activation of monocytes and macrophages
Purity gt990Clinical Data LaunchedSize 1 mg 5 mg 10 mg
MK6-83Cat No HY-110238
MK6-83 is a new candidate agonist of TRPML1with an improved efficacy and potency MK6-83 hasthe potential for Mucolipidosis type IV study
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
ML204Cat No HY-12949
ML204 is a novel potent antagonist thatselectively modulates native TRPC4C5 ionchannels
Purity 9831Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
ML204 hydrochlorideCat No HY-12949A
ML204 hydrochloride is a novel potent selectiveTRPC4 channel inhibitor with IC50 of 096 uMexhibit 19-fold selectivity against TRPC6 channelsin similar fluorescent assays target ML204 IC50096 uM In vitro ML204 inhibited TRPC4β-mediatedintracellular Ca2+ rise
Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) Cat No HY-118628
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is abroad spectrum inhibitorPhospholipase A (PLA )2 2
and blockerTRP channel
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Nonivamide (Pelargonic acid vanillylamide Nonanoic acid
vanillylamide Pseudocapsaicin) Cat No HY-17568
Nonivamide is a ltbltTRPV1 agonist whichexhibits 4d- value of 51 mgL in staticEC50
toxicity tests
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 5 g
OMDM-5Cat No HY-135881
OMDM-5 is a selective inhibitor of anandamide with a of 48 μMcellular uptake (ACU) Ki
OMDM-5 is also a potent vanilloid receptor type 1 agonist with an of 75 nM(VR1 TRPV1) EC50
and shows weakly active as cannabinoid receptortype 1 (CB1) ligand (K =49 μM)i
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OMDM-6Cat No HY-135882
OMDM-6 is a hybrid agonist of vanilloid receptor ( =75 nM) and type 1 (VR1 TRPV1) EC50 cannabinoid
( =32 μM) OMDM-6receptor type 1 (CB1) Ki
inhibits withanandamide cellular uptake (ACU)a of 70 μMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OptovinCat No HY-12809
Optovin is a reversible photoactive TRPA1activator stimulates human TRPA1 channels invitro and enables repeated photoactivation ofmotor behaviors in wild-type zebrafish (EC50 = 2μM)
Purity 9954Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
PF-04745637Cat No HY-120689
PF-04745637 is a potent and selective TRPA1antagonist with an of 17 nM for human TRPA1IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 9
Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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AM-0902Cat No HY-108329
AM-0902 is a potent selective transient receptorpotential A1 ( ) antagonist with s of 71TRPA1 IC50
and 131 nM for and respectivelyrTRPA1 hTRPA1
Purity 9967Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
AM12Cat No HY-128561
AM12 inhibits Lanthanide-evoked activityTRPC5with an of 028 μMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AMG 333Cat No HY-112703
AMG 333 is a potent and highly selective TRPM8antagonist with an of 13 nMIC50
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
AMG 517Cat No HY-10634
AMG 517 is a potent and selective vanilloidreceptor-1 ( ) antagonist with an of 05TRPV1 IC50
nM
Purity 9997Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
AMG2850Cat No HY-104059
AMG2850 is a potent orally bioavailable andselective transient receptor potential melastatin 8
antagonist(TRPM8)
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
AMG9810Cat No HY-101736
AMG9810 is a selective and competitive vanilloidreceptor 1 ( ) antagonist with values ofTRPV1 IC50
245 and 856 nM for human and rat TRPV1repectively
Purity 9976Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Amiloride (MK-870) Cat No HY-B0285
Amiloride (MK-870) is an inhibitor of bothepithelial sodium channel ( ) andENaCurokinase-type plasminogen activator receptor( ) Amiloride is a blocker of uTPA polycystin-2(PC2 ) channelTRPP2
Purity gt98Clinical Data LaunchedSize 1 mg 5 mg
Amiloride hydrochloride (MK-870 hydrochloride) Cat No HY-B0285A
Amiloride hydrochloride (MK-870 hydrochloride) isan inhibitor of both epithelial sodium channel( ) and urokinase-type plasminogen activatorENaCreceptor ( ) Amiloride hydrochloride is auTPAblocker of (PC2 ) channelpolycystin-2 TRPP2
Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg
Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) Cat No HY-B0285B
Amiloride hydrochloride dihydrate (MK-870hydrochloride dihydrate) is an inhibitor of bothepithelial sodium channel ( ) andENaCurokinase-type plasminogen activator receptor( ) Amiloride hydrochloride dihydrate is auTPAblocker of (PC2 ) channelpolycystin-2 TRPP2
Purity 9856Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Asivatrep (PAC-14028) Cat No HY-12777
Asivatrep (PAC-14028) is a potent and selectivetransient receptor potential vanilloid type I( ) antagonistTRPV1
Purity 9514Clinical Data Phase 3Size 10 mM times 1 mL 1 mg 5 mg 10 mg 50 mg 100 mg
wwwMedChemExpresscom 3
ASP7663Cat No HY-101907
ASP7663 is an orally active and selective TRPA1agonist ASP7663 exerts both anti-constipation andanti-abdominal pain actions
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
BCTCCat No HY-19960
BCTC is a potent and specific inhibitor oftransient receptor potential cation channelsubfamily M member 8 (TRPM8) in prostate cancer(PCa) DU145 cells
Purity 9723Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Beta-EudesmolCat No HY-N6018
Beta-Eudesmol is a natural oxygenatedsesquiterpene activates with an hTRPA1 EC50
of 325 μM Beta-Eudesmol increases appetitethrough TRPA1
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
BI-749327Cat No HY-111925
BI-749327 is a potent high selectivity and orallybioavailable antagonist with s of 13TRPC6 IC50
nM 19 nM and 15 nM for mouse human and guineapig TRPC6 respectively BI-749327 is 85-fold moreselective for mouse TRPC6 than TRPC3 and 42-foldversus TRPC7
Purity 9953Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Bisandrographolide CCat No HY-N2941
Bisandrographolide C is an unusual dimer ofent-labdane diterpenoid isolated and identifiedfrom Andrographis paniculata
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Caffeic acidCat No HY-N0172
Caffeic acid is an inhibitor of both ionTRPV1channel and ( )5-Lipoxygenase 5-LO
Purity 9880Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 5 g
Camphor ((plusmn)-Camphor) Cat No HY-N0808
Camphor ((plusmn)-Camphor) is a topical anti-infectiveand anti-pruritic and internally as a stimulantand carminative However Camphor is poisonouswhen ingested Antiviral antitussive andanticancer activities Camphor is a TRPV3agonist
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Capsaicin ((E)-Capsaicin) Cat No HY-10448
Capsaicin ((E)-Capsaicin) is a mixture ofCapsaicin and Dihydrocapsaicin Capsaici is a
agonist with an of 029 μM in HEK293TRPV1 EC50
cells
Purity 9901Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
CapsazepineCat No HY-15640
Capsazepine is a synthetic analogue of the sensoryneurone excitotoxin and an antagonist of TRPV1
with an of 562 nMreceptor IC50
Purity 9917Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Chembridge-5861528 (TCS 5861528) Cat No HY-15065
Chembridge-5861528 is a TRPA1 channel blocker thatantagonizes AITC- and 4-HNE-evoked calcium influx(IC50 values are 143 and 187μM respectively)
Purity 9704Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
4 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Cyclic ADP-ribose (cADPR) Cat No HY-N7395
Cyclic ADP-ribose (cADPR) is a potent secondmessenger for that iscalcium mobilizationsynthesized from NAD by a ADP-ribosyl cyclase+
Purity gt98Clinical Data No Development ReportedSize 500 μg
D-3263Cat No HY-16162
D-3263 is an agonist of transient receptorpotential melastatin member 8 ( ) withTRPM8potential antineoplastic activity
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
D-3263 hydrochlorideCat No HY-16162A
D-3263 hydrochloride is an enteric-coated orallybioavailable (transient receptor potentialmelastatin member 8) agonistTRPM8
Purity 9801Clinical Data Phase 1Size 10 mM times 1 mL 1 mg 5 mg 10 mg 50 mg 100 mg
DihydrocapsaicinCat No HY-N0361
Dihydrocapsaicin is a natural capsaicin acts as aselective agonist and also increases p-AktTRPV1levels Dihydrocapsaicin enhances thehypothermia-induced neuroprotection
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Diphenyleneiodonium chloride (DPI) Cat No HY-100965
Diphenyleneiodonium chloride is a NADPH oxidase( ) inhibitor and also functions as a NOX TRPA1activator with an of 1 to 3 μMEC50
Diphenyleneiodonium chloride selectively inhibitsintracellular reactive oxygen species
Purity 9987Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
DS88790512Cat No HY-112298
DS88790512 is a potent selective and orallybioavailable inhibitor with an of 11TRPC6 IC50
nM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
EIPA (L593754 MH 12-43) Cat No HY-101840
EIPA (L593754) is a inhibitor withTRPP3 channelan of 105 μM EIPA also inhibitsIC50
( ) andNa H -exchanger+ + NHEmacropinocytosis
Purity 9973Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
EIPA hydrochloride (L593754 hydrochloride MH 12-43 hydrochloride) Cat No HY-101840A
EIPA hydrochloride (L593754 hydrochloride) is a inhibitor with an of 105 μMTRPP3 channel IC50
EIPA hydrochloride also inhibits ( ) andNa H -exchanger+ + NHE
macropinocytosis
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GFB-8438Cat No HY-133012
GFB-8438 is a potent and subtype selective TRPC5inhibitor with s of 018 and 029 μM ofIC50
hTRPC5 and hTRPC4 respectively GFB-8438 showsexcellent selectivity against TRPC6 other TRPfamily members NaV 15 as well as limitedactivity against the hERG channel
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
GSK1016790ACat No HY-19608
GSK1016790A is a potent transient receptorpotential vanilloid 4 ( ) activatorTRPV4
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 5
GSK1702934ACat No HY-111098
GSK1702934A is a selective agonistTRPC3GSK1702934A modulates cardiac contractility and farrhythmogenesis by activation of TRPC3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GSK205Cat No HY-120691A
GSK205 is a potent selective antagonistTRPV4with an of 419 μM for inhibitingIC50
-mediated Ca influxTRPV4 2+
Purity 9945Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2193874Cat No HY-100720
GSK2193874 is an orally active potent andselective antagonist with s of 2 nM andTRPV4 IC50
40 nM for and rTRPV4 hTRPV4
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2798745Cat No HY-19765
GSK2798745 is a first-in-class highly potentselective orally active transient receptorpotential vanilloid 4 blocker(TRPV4) ion channelwith s of 18 and 16 nM for hTRPV4 andIC50
rTRPV4 respectively
Purity 9827Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg
GSK3395879Cat No HY-112202
GSK3395879 is a selective and orally bioavailabletransient receptor potential vanilloid-4 ( )TRPV4antagonist with an of 1 nM for hTRPV4IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
HC-030031Cat No HY-15064
HC-030031 is a potent and selective TRPA1inhibitor which antagonizes AITC- andformalin-evoked calcium influx with s ofIC50
62plusmn02 and 53plusmn02 μM respectively
Purity 9591Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
HC-067047Cat No HY-100208
HC-067047 is a potent and selective TRPV4antagonist and reversibly inhibits currentsthrough the human rat and mouse orthologsTRPV4with values of 48 nM 133 nM and 17 nMIC50
respectively
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
HC-070Cat No HY-112302
HC-070 is an antagonist of withTRPC4TRPC5s of 93 nM and 46 nM for hTRPC5 and hTRPC4 inIC50
cells respectively
Purity 9823Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Hydroxy-α-sanshoolCat No HY-N6825
Hydroxy-α-sanshool is an alkylamide isolatedfrom acts as a covalent and pepper TRPA1 TRPV1non-covalent agonist with s of 69 and 11EC50
microM respectively
Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) Cat No HY-116330A
Hyperforin dicyclohexylammonium salt (HyperforinDCHA) is a transient receptor canonical 6 (TRPC6)channels activator Hyperforindicyclohexylammonium salt modulates Ca levels2+
by activating Ca -conducting non-selective2+
canonical TRPC6 channels
Purity 9817Clinical Data No Development ReportedSize 500 μg 1 mg
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IA-Alkyne (Iodoacetamide-alkyne N-Hex-5-ynyl-2-iodo-acetamide) Cat No HY-136205
IA-Alkyne (Iodoacetamide-alkyneN-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel
agonist and has the potential for the(TRPC)study of respiratory infection IA-Alkyne can beused to develop an isotopically tagged forprobequantitative profilingcysteine-reactivity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Icilin (AG-3-5) Cat No HY-11062
Icilin(AG 3-5) is a synthetic super-agonist ofTRPM8 ion channel
Purity gt960Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Imperatorin (Ammidin) Cat No HY-N0285
Imperatorin is an effective of NO synthesisinhibitor ( =92 μmol) which also is a IC50 BChEinhibitor ( =314 μmol) Imperatorin is a weakIC50
agonist of with of 126plusmn32 μMTRPV1 EC50
Purity 9581Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
JNJ-17203212Cat No HY-100129
JNJ-17203212 is a novel and selective TRPV1antagonist with IC50 of 65 nM and 102 nM forhuman TRPV1 and rat TRPV1
Purity 9994Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
JT010Cat No HY-111132
JT010 is a potent agonist of with an TRPA1 EC50
of 065 nM
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
JYL 1421 (SC 0030) Cat No HY-100668
JYL 1421 is a antagonist with anTRPV1 receptor of 8 nMIC50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
Linopirdine (DuP 996) Cat No HY-W020468
Linopirdine (DuP 996) is an orally activeselective M-type K current (IM Kv7 KCNQ+
inhibitor with an of 24 μMChannels) IC50
Linopirdine is a agonist Linopirdine aTRPV1putative cognition enhancing drug increasesacetylcholine release in rat brain tissue
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mavatrep (JNJ-39439335) Cat No HY-16935
Mavatrep is an orally bioavailable TRPV1antagonist (Ki=65 nM) exhibits minimal effect onthe enzymatic activity (IC50 gt 25 μM) of CYPisoforms 3A4 1A2 and 2D6
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
MDR-652Cat No HY-136363
MDR-652 is a highly specific and efficacious ( )transient receptor potential vanilloid 1 TRPV1
ligand with agonist activity The s are 114 andKi
238 nM for hTRPV1 and rTRPV1 respectively Thes are 505 and 93 nM for hTRPV1 and rTRPV1EC50
respectively Potent topical analgesic activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Methyl syringateCat No HY-W002116
Methyl syringate a chemical marker of asphodelmonofloral honey is an efficient phenolicmediator for bacterial and fungal laccases Methylsyringate is a agonistTRPA1
Purity 9976Clinical Data No Development ReportedSize 100 mg
wwwMedChemExpresscom 7
Mifamurtide (MTP-PE L-MTP-PE CGP 19835) Cat No HY-13682
Mifamurtide (MTP-PE CGP19835) is a drug againstosteosarcoma Mifamurtide is an immunomodulatorwith antitumor effects that appear to be mediatedvia activation of monocytes and macrophages
Purity gt990Clinical Data LaunchedSize 1 mg 5 mg 10 mg
MK6-83Cat No HY-110238
MK6-83 is a new candidate agonist of TRPML1with an improved efficacy and potency MK6-83 hasthe potential for Mucolipidosis type IV study
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
ML204Cat No HY-12949
ML204 is a novel potent antagonist thatselectively modulates native TRPC4C5 ionchannels
Purity 9831Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
ML204 hydrochlorideCat No HY-12949A
ML204 hydrochloride is a novel potent selectiveTRPC4 channel inhibitor with IC50 of 096 uMexhibit 19-fold selectivity against TRPC6 channelsin similar fluorescent assays target ML204 IC50096 uM In vitro ML204 inhibited TRPC4β-mediatedintracellular Ca2+ rise
Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) Cat No HY-118628
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is abroad spectrum inhibitorPhospholipase A (PLA )2 2
and blockerTRP channel
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Nonivamide (Pelargonic acid vanillylamide Nonanoic acid
vanillylamide Pseudocapsaicin) Cat No HY-17568
Nonivamide is a ltbltTRPV1 agonist whichexhibits 4d- value of 51 mgL in staticEC50
toxicity tests
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 5 g
OMDM-5Cat No HY-135881
OMDM-5 is a selective inhibitor of anandamide with a of 48 μMcellular uptake (ACU) Ki
OMDM-5 is also a potent vanilloid receptor type 1 agonist with an of 75 nM(VR1 TRPV1) EC50
and shows weakly active as cannabinoid receptortype 1 (CB1) ligand (K =49 μM)i
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OMDM-6Cat No HY-135882
OMDM-6 is a hybrid agonist of vanilloid receptor ( =75 nM) and type 1 (VR1 TRPV1) EC50 cannabinoid
( =32 μM) OMDM-6receptor type 1 (CB1) Ki
inhibits withanandamide cellular uptake (ACU)a of 70 μMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OptovinCat No HY-12809
Optovin is a reversible photoactive TRPA1activator stimulates human TRPA1 channels invitro and enables repeated photoactivation ofmotor behaviors in wild-type zebrafish (EC50 = 2μM)
Purity 9954Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
PF-04745637Cat No HY-120689
PF-04745637 is a potent and selective TRPA1antagonist with an of 17 nM for human TRPA1IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 9
Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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ASP7663Cat No HY-101907
ASP7663 is an orally active and selective TRPA1agonist ASP7663 exerts both anti-constipation andanti-abdominal pain actions
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
BCTCCat No HY-19960
BCTC is a potent and specific inhibitor oftransient receptor potential cation channelsubfamily M member 8 (TRPM8) in prostate cancer(PCa) DU145 cells
Purity 9723Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Beta-EudesmolCat No HY-N6018
Beta-Eudesmol is a natural oxygenatedsesquiterpene activates with an hTRPA1 EC50
of 325 μM Beta-Eudesmol increases appetitethrough TRPA1
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
BI-749327Cat No HY-111925
BI-749327 is a potent high selectivity and orallybioavailable antagonist with s of 13TRPC6 IC50
nM 19 nM and 15 nM for mouse human and guineapig TRPC6 respectively BI-749327 is 85-fold moreselective for mouse TRPC6 than TRPC3 and 42-foldversus TRPC7
Purity 9953Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Bisandrographolide CCat No HY-N2941
Bisandrographolide C is an unusual dimer ofent-labdane diterpenoid isolated and identifiedfrom Andrographis paniculata
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Caffeic acidCat No HY-N0172
Caffeic acid is an inhibitor of both ionTRPV1channel and ( )5-Lipoxygenase 5-LO
Purity 9880Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 5 g
Camphor ((plusmn)-Camphor) Cat No HY-N0808
Camphor ((plusmn)-Camphor) is a topical anti-infectiveand anti-pruritic and internally as a stimulantand carminative However Camphor is poisonouswhen ingested Antiviral antitussive andanticancer activities Camphor is a TRPV3agonist
Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 100 mg
Capsaicin ((E)-Capsaicin) Cat No HY-10448
Capsaicin ((E)-Capsaicin) is a mixture ofCapsaicin and Dihydrocapsaicin Capsaici is a
agonist with an of 029 μM in HEK293TRPV1 EC50
cells
Purity 9901Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg
CapsazepineCat No HY-15640
Capsazepine is a synthetic analogue of the sensoryneurone excitotoxin and an antagonist of TRPV1
with an of 562 nMreceptor IC50
Purity 9917Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
Chembridge-5861528 (TCS 5861528) Cat No HY-15065
Chembridge-5861528 is a TRPA1 channel blocker thatantagonizes AITC- and 4-HNE-evoked calcium influx(IC50 values are 143 and 187μM respectively)
Purity 9704Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
4 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Cyclic ADP-ribose (cADPR) Cat No HY-N7395
Cyclic ADP-ribose (cADPR) is a potent secondmessenger for that iscalcium mobilizationsynthesized from NAD by a ADP-ribosyl cyclase+
Purity gt98Clinical Data No Development ReportedSize 500 μg
D-3263Cat No HY-16162
D-3263 is an agonist of transient receptorpotential melastatin member 8 ( ) withTRPM8potential antineoplastic activity
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
D-3263 hydrochlorideCat No HY-16162A
D-3263 hydrochloride is an enteric-coated orallybioavailable (transient receptor potentialmelastatin member 8) agonistTRPM8
Purity 9801Clinical Data Phase 1Size 10 mM times 1 mL 1 mg 5 mg 10 mg 50 mg 100 mg
DihydrocapsaicinCat No HY-N0361
Dihydrocapsaicin is a natural capsaicin acts as aselective agonist and also increases p-AktTRPV1levels Dihydrocapsaicin enhances thehypothermia-induced neuroprotection
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Diphenyleneiodonium chloride (DPI) Cat No HY-100965
Diphenyleneiodonium chloride is a NADPH oxidase( ) inhibitor and also functions as a NOX TRPA1activator with an of 1 to 3 μMEC50
Diphenyleneiodonium chloride selectively inhibitsintracellular reactive oxygen species
Purity 9987Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
DS88790512Cat No HY-112298
DS88790512 is a potent selective and orallybioavailable inhibitor with an of 11TRPC6 IC50
nM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
EIPA (L593754 MH 12-43) Cat No HY-101840
EIPA (L593754) is a inhibitor withTRPP3 channelan of 105 μM EIPA also inhibitsIC50
( ) andNa H -exchanger+ + NHEmacropinocytosis
Purity 9973Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
EIPA hydrochloride (L593754 hydrochloride MH 12-43 hydrochloride) Cat No HY-101840A
EIPA hydrochloride (L593754 hydrochloride) is a inhibitor with an of 105 μMTRPP3 channel IC50
EIPA hydrochloride also inhibits ( ) andNa H -exchanger+ + NHE
macropinocytosis
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GFB-8438Cat No HY-133012
GFB-8438 is a potent and subtype selective TRPC5inhibitor with s of 018 and 029 μM ofIC50
hTRPC5 and hTRPC4 respectively GFB-8438 showsexcellent selectivity against TRPC6 other TRPfamily members NaV 15 as well as limitedactivity against the hERG channel
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
GSK1016790ACat No HY-19608
GSK1016790A is a potent transient receptorpotential vanilloid 4 ( ) activatorTRPV4
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 5
GSK1702934ACat No HY-111098
GSK1702934A is a selective agonistTRPC3GSK1702934A modulates cardiac contractility and farrhythmogenesis by activation of TRPC3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GSK205Cat No HY-120691A
GSK205 is a potent selective antagonistTRPV4with an of 419 μM for inhibitingIC50
-mediated Ca influxTRPV4 2+
Purity 9945Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2193874Cat No HY-100720
GSK2193874 is an orally active potent andselective antagonist with s of 2 nM andTRPV4 IC50
40 nM for and rTRPV4 hTRPV4
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2798745Cat No HY-19765
GSK2798745 is a first-in-class highly potentselective orally active transient receptorpotential vanilloid 4 blocker(TRPV4) ion channelwith s of 18 and 16 nM for hTRPV4 andIC50
rTRPV4 respectively
Purity 9827Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg
GSK3395879Cat No HY-112202
GSK3395879 is a selective and orally bioavailabletransient receptor potential vanilloid-4 ( )TRPV4antagonist with an of 1 nM for hTRPV4IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
HC-030031Cat No HY-15064
HC-030031 is a potent and selective TRPA1inhibitor which antagonizes AITC- andformalin-evoked calcium influx with s ofIC50
62plusmn02 and 53plusmn02 μM respectively
Purity 9591Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
HC-067047Cat No HY-100208
HC-067047 is a potent and selective TRPV4antagonist and reversibly inhibits currentsthrough the human rat and mouse orthologsTRPV4with values of 48 nM 133 nM and 17 nMIC50
respectively
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
HC-070Cat No HY-112302
HC-070 is an antagonist of withTRPC4TRPC5s of 93 nM and 46 nM for hTRPC5 and hTRPC4 inIC50
cells respectively
Purity 9823Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Hydroxy-α-sanshoolCat No HY-N6825
Hydroxy-α-sanshool is an alkylamide isolatedfrom acts as a covalent and pepper TRPA1 TRPV1non-covalent agonist with s of 69 and 11EC50
microM respectively
Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) Cat No HY-116330A
Hyperforin dicyclohexylammonium salt (HyperforinDCHA) is a transient receptor canonical 6 (TRPC6)channels activator Hyperforindicyclohexylammonium salt modulates Ca levels2+
by activating Ca -conducting non-selective2+
canonical TRPC6 channels
Purity 9817Clinical Data No Development ReportedSize 500 μg 1 mg
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IA-Alkyne (Iodoacetamide-alkyne N-Hex-5-ynyl-2-iodo-acetamide) Cat No HY-136205
IA-Alkyne (Iodoacetamide-alkyneN-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel
agonist and has the potential for the(TRPC)study of respiratory infection IA-Alkyne can beused to develop an isotopically tagged forprobequantitative profilingcysteine-reactivity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Icilin (AG-3-5) Cat No HY-11062
Icilin(AG 3-5) is a synthetic super-agonist ofTRPM8 ion channel
Purity gt960Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Imperatorin (Ammidin) Cat No HY-N0285
Imperatorin is an effective of NO synthesisinhibitor ( =92 μmol) which also is a IC50 BChEinhibitor ( =314 μmol) Imperatorin is a weakIC50
agonist of with of 126plusmn32 μMTRPV1 EC50
Purity 9581Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
JNJ-17203212Cat No HY-100129
JNJ-17203212 is a novel and selective TRPV1antagonist with IC50 of 65 nM and 102 nM forhuman TRPV1 and rat TRPV1
Purity 9994Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
JT010Cat No HY-111132
JT010 is a potent agonist of with an TRPA1 EC50
of 065 nM
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
JYL 1421 (SC 0030) Cat No HY-100668
JYL 1421 is a antagonist with anTRPV1 receptor of 8 nMIC50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
Linopirdine (DuP 996) Cat No HY-W020468
Linopirdine (DuP 996) is an orally activeselective M-type K current (IM Kv7 KCNQ+
inhibitor with an of 24 μMChannels) IC50
Linopirdine is a agonist Linopirdine aTRPV1putative cognition enhancing drug increasesacetylcholine release in rat brain tissue
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mavatrep (JNJ-39439335) Cat No HY-16935
Mavatrep is an orally bioavailable TRPV1antagonist (Ki=65 nM) exhibits minimal effect onthe enzymatic activity (IC50 gt 25 μM) of CYPisoforms 3A4 1A2 and 2D6
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
MDR-652Cat No HY-136363
MDR-652 is a highly specific and efficacious ( )transient receptor potential vanilloid 1 TRPV1
ligand with agonist activity The s are 114 andKi
238 nM for hTRPV1 and rTRPV1 respectively Thes are 505 and 93 nM for hTRPV1 and rTRPV1EC50
respectively Potent topical analgesic activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Methyl syringateCat No HY-W002116
Methyl syringate a chemical marker of asphodelmonofloral honey is an efficient phenolicmediator for bacterial and fungal laccases Methylsyringate is a agonistTRPA1
Purity 9976Clinical Data No Development ReportedSize 100 mg
wwwMedChemExpresscom 7
Mifamurtide (MTP-PE L-MTP-PE CGP 19835) Cat No HY-13682
Mifamurtide (MTP-PE CGP19835) is a drug againstosteosarcoma Mifamurtide is an immunomodulatorwith antitumor effects that appear to be mediatedvia activation of monocytes and macrophages
Purity gt990Clinical Data LaunchedSize 1 mg 5 mg 10 mg
MK6-83Cat No HY-110238
MK6-83 is a new candidate agonist of TRPML1with an improved efficacy and potency MK6-83 hasthe potential for Mucolipidosis type IV study
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
ML204Cat No HY-12949
ML204 is a novel potent antagonist thatselectively modulates native TRPC4C5 ionchannels
Purity 9831Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
ML204 hydrochlorideCat No HY-12949A
ML204 hydrochloride is a novel potent selectiveTRPC4 channel inhibitor with IC50 of 096 uMexhibit 19-fold selectivity against TRPC6 channelsin similar fluorescent assays target ML204 IC50096 uM In vitro ML204 inhibited TRPC4β-mediatedintracellular Ca2+ rise
Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) Cat No HY-118628
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is abroad spectrum inhibitorPhospholipase A (PLA )2 2
and blockerTRP channel
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Nonivamide (Pelargonic acid vanillylamide Nonanoic acid
vanillylamide Pseudocapsaicin) Cat No HY-17568
Nonivamide is a ltbltTRPV1 agonist whichexhibits 4d- value of 51 mgL in staticEC50
toxicity tests
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 5 g
OMDM-5Cat No HY-135881
OMDM-5 is a selective inhibitor of anandamide with a of 48 μMcellular uptake (ACU) Ki
OMDM-5 is also a potent vanilloid receptor type 1 agonist with an of 75 nM(VR1 TRPV1) EC50
and shows weakly active as cannabinoid receptortype 1 (CB1) ligand (K =49 μM)i
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OMDM-6Cat No HY-135882
OMDM-6 is a hybrid agonist of vanilloid receptor ( =75 nM) and type 1 (VR1 TRPV1) EC50 cannabinoid
( =32 μM) OMDM-6receptor type 1 (CB1) Ki
inhibits withanandamide cellular uptake (ACU)a of 70 μMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OptovinCat No HY-12809
Optovin is a reversible photoactive TRPA1activator stimulates human TRPA1 channels invitro and enables repeated photoactivation ofmotor behaviors in wild-type zebrafish (EC50 = 2μM)
Purity 9954Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
PF-04745637Cat No HY-120689
PF-04745637 is a potent and selective TRPA1antagonist with an of 17 nM for human TRPA1IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 9
Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Cyclic ADP-ribose (cADPR) Cat No HY-N7395
Cyclic ADP-ribose (cADPR) is a potent secondmessenger for that iscalcium mobilizationsynthesized from NAD by a ADP-ribosyl cyclase+
Purity gt98Clinical Data No Development ReportedSize 500 μg
D-3263Cat No HY-16162
D-3263 is an agonist of transient receptorpotential melastatin member 8 ( ) withTRPM8potential antineoplastic activity
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
D-3263 hydrochlorideCat No HY-16162A
D-3263 hydrochloride is an enteric-coated orallybioavailable (transient receptor potentialmelastatin member 8) agonistTRPM8
Purity 9801Clinical Data Phase 1Size 10 mM times 1 mL 1 mg 5 mg 10 mg 50 mg 100 mg
DihydrocapsaicinCat No HY-N0361
Dihydrocapsaicin is a natural capsaicin acts as aselective agonist and also increases p-AktTRPV1levels Dihydrocapsaicin enhances thehypothermia-induced neuroprotection
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg
Diphenyleneiodonium chloride (DPI) Cat No HY-100965
Diphenyleneiodonium chloride is a NADPH oxidase( ) inhibitor and also functions as a NOX TRPA1activator with an of 1 to 3 μMEC50
Diphenyleneiodonium chloride selectively inhibitsintracellular reactive oxygen species
Purity 9987Clinical Data Phase 4Size 10 mM times 1 mL 10 mg 50 mg 100 mg
DS88790512Cat No HY-112298
DS88790512 is a potent selective and orallybioavailable inhibitor with an of 11TRPC6 IC50
nM
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
EIPA (L593754 MH 12-43) Cat No HY-101840
EIPA (L593754) is a inhibitor withTRPP3 channelan of 105 μM EIPA also inhibitsIC50
( ) andNa H -exchanger+ + NHEmacropinocytosis
Purity 9973Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
EIPA hydrochloride (L593754 hydrochloride MH 12-43 hydrochloride) Cat No HY-101840A
EIPA hydrochloride (L593754 hydrochloride) is a inhibitor with an of 105 μMTRPP3 channel IC50
EIPA hydrochloride also inhibits ( ) andNa H -exchanger+ + NHE
macropinocytosis
Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
GFB-8438Cat No HY-133012
GFB-8438 is a potent and subtype selective TRPC5inhibitor with s of 018 and 029 μM ofIC50
hTRPC5 and hTRPC4 respectively GFB-8438 showsexcellent selectivity against TRPC6 other TRPfamily members NaV 15 as well as limitedactivity against the hERG channel
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
GSK1016790ACat No HY-19608
GSK1016790A is a potent transient receptorpotential vanilloid 4 ( ) activatorTRPV4
Purity 9965Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
wwwMedChemExpresscom 5
GSK1702934ACat No HY-111098
GSK1702934A is a selective agonistTRPC3GSK1702934A modulates cardiac contractility and farrhythmogenesis by activation of TRPC3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GSK205Cat No HY-120691A
GSK205 is a potent selective antagonistTRPV4with an of 419 μM for inhibitingIC50
-mediated Ca influxTRPV4 2+
Purity 9945Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2193874Cat No HY-100720
GSK2193874 is an orally active potent andselective antagonist with s of 2 nM andTRPV4 IC50
40 nM for and rTRPV4 hTRPV4
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2798745Cat No HY-19765
GSK2798745 is a first-in-class highly potentselective orally active transient receptorpotential vanilloid 4 blocker(TRPV4) ion channelwith s of 18 and 16 nM for hTRPV4 andIC50
rTRPV4 respectively
Purity 9827Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg
GSK3395879Cat No HY-112202
GSK3395879 is a selective and orally bioavailabletransient receptor potential vanilloid-4 ( )TRPV4antagonist with an of 1 nM for hTRPV4IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
HC-030031Cat No HY-15064
HC-030031 is a potent and selective TRPA1inhibitor which antagonizes AITC- andformalin-evoked calcium influx with s ofIC50
62plusmn02 and 53plusmn02 μM respectively
Purity 9591Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
HC-067047Cat No HY-100208
HC-067047 is a potent and selective TRPV4antagonist and reversibly inhibits currentsthrough the human rat and mouse orthologsTRPV4with values of 48 nM 133 nM and 17 nMIC50
respectively
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
HC-070Cat No HY-112302
HC-070 is an antagonist of withTRPC4TRPC5s of 93 nM and 46 nM for hTRPC5 and hTRPC4 inIC50
cells respectively
Purity 9823Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Hydroxy-α-sanshoolCat No HY-N6825
Hydroxy-α-sanshool is an alkylamide isolatedfrom acts as a covalent and pepper TRPA1 TRPV1non-covalent agonist with s of 69 and 11EC50
microM respectively
Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) Cat No HY-116330A
Hyperforin dicyclohexylammonium salt (HyperforinDCHA) is a transient receptor canonical 6 (TRPC6)channels activator Hyperforindicyclohexylammonium salt modulates Ca levels2+
by activating Ca -conducting non-selective2+
canonical TRPC6 channels
Purity 9817Clinical Data No Development ReportedSize 500 μg 1 mg
6 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
IA-Alkyne (Iodoacetamide-alkyne N-Hex-5-ynyl-2-iodo-acetamide) Cat No HY-136205
IA-Alkyne (Iodoacetamide-alkyneN-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel
agonist and has the potential for the(TRPC)study of respiratory infection IA-Alkyne can beused to develop an isotopically tagged forprobequantitative profilingcysteine-reactivity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Icilin (AG-3-5) Cat No HY-11062
Icilin(AG 3-5) is a synthetic super-agonist ofTRPM8 ion channel
Purity gt960Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Imperatorin (Ammidin) Cat No HY-N0285
Imperatorin is an effective of NO synthesisinhibitor ( =92 μmol) which also is a IC50 BChEinhibitor ( =314 μmol) Imperatorin is a weakIC50
agonist of with of 126plusmn32 μMTRPV1 EC50
Purity 9581Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
JNJ-17203212Cat No HY-100129
JNJ-17203212 is a novel and selective TRPV1antagonist with IC50 of 65 nM and 102 nM forhuman TRPV1 and rat TRPV1
Purity 9994Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
JT010Cat No HY-111132
JT010 is a potent agonist of with an TRPA1 EC50
of 065 nM
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
JYL 1421 (SC 0030) Cat No HY-100668
JYL 1421 is a antagonist with anTRPV1 receptor of 8 nMIC50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
Linopirdine (DuP 996) Cat No HY-W020468
Linopirdine (DuP 996) is an orally activeselective M-type K current (IM Kv7 KCNQ+
inhibitor with an of 24 μMChannels) IC50
Linopirdine is a agonist Linopirdine aTRPV1putative cognition enhancing drug increasesacetylcholine release in rat brain tissue
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mavatrep (JNJ-39439335) Cat No HY-16935
Mavatrep is an orally bioavailable TRPV1antagonist (Ki=65 nM) exhibits minimal effect onthe enzymatic activity (IC50 gt 25 μM) of CYPisoforms 3A4 1A2 and 2D6
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
MDR-652Cat No HY-136363
MDR-652 is a highly specific and efficacious ( )transient receptor potential vanilloid 1 TRPV1
ligand with agonist activity The s are 114 andKi
238 nM for hTRPV1 and rTRPV1 respectively Thes are 505 and 93 nM for hTRPV1 and rTRPV1EC50
respectively Potent topical analgesic activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Methyl syringateCat No HY-W002116
Methyl syringate a chemical marker of asphodelmonofloral honey is an efficient phenolicmediator for bacterial and fungal laccases Methylsyringate is a agonistTRPA1
Purity 9976Clinical Data No Development ReportedSize 100 mg
wwwMedChemExpresscom 7
Mifamurtide (MTP-PE L-MTP-PE CGP 19835) Cat No HY-13682
Mifamurtide (MTP-PE CGP19835) is a drug againstosteosarcoma Mifamurtide is an immunomodulatorwith antitumor effects that appear to be mediatedvia activation of monocytes and macrophages
Purity gt990Clinical Data LaunchedSize 1 mg 5 mg 10 mg
MK6-83Cat No HY-110238
MK6-83 is a new candidate agonist of TRPML1with an improved efficacy and potency MK6-83 hasthe potential for Mucolipidosis type IV study
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
ML204Cat No HY-12949
ML204 is a novel potent antagonist thatselectively modulates native TRPC4C5 ionchannels
Purity 9831Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
ML204 hydrochlorideCat No HY-12949A
ML204 hydrochloride is a novel potent selectiveTRPC4 channel inhibitor with IC50 of 096 uMexhibit 19-fold selectivity against TRPC6 channelsin similar fluorescent assays target ML204 IC50096 uM In vitro ML204 inhibited TRPC4β-mediatedintracellular Ca2+ rise
Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) Cat No HY-118628
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is abroad spectrum inhibitorPhospholipase A (PLA )2 2
and blockerTRP channel
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Nonivamide (Pelargonic acid vanillylamide Nonanoic acid
vanillylamide Pseudocapsaicin) Cat No HY-17568
Nonivamide is a ltbltTRPV1 agonist whichexhibits 4d- value of 51 mgL in staticEC50
toxicity tests
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 5 g
OMDM-5Cat No HY-135881
OMDM-5 is a selective inhibitor of anandamide with a of 48 μMcellular uptake (ACU) Ki
OMDM-5 is also a potent vanilloid receptor type 1 agonist with an of 75 nM(VR1 TRPV1) EC50
and shows weakly active as cannabinoid receptortype 1 (CB1) ligand (K =49 μM)i
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OMDM-6Cat No HY-135882
OMDM-6 is a hybrid agonist of vanilloid receptor ( =75 nM) and type 1 (VR1 TRPV1) EC50 cannabinoid
( =32 μM) OMDM-6receptor type 1 (CB1) Ki
inhibits withanandamide cellular uptake (ACU)a of 70 μMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OptovinCat No HY-12809
Optovin is a reversible photoactive TRPA1activator stimulates human TRPA1 channels invitro and enables repeated photoactivation ofmotor behaviors in wild-type zebrafish (EC50 = 2μM)
Purity 9954Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
PF-04745637Cat No HY-120689
PF-04745637 is a potent and selective TRPA1antagonist with an of 17 nM for human TRPA1IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 9
Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
GSK1702934ACat No HY-111098
GSK1702934A is a selective agonistTRPC3GSK1702934A modulates cardiac contractility and farrhythmogenesis by activation of TRPC3
Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
GSK205Cat No HY-120691A
GSK205 is a potent selective antagonistTRPV4with an of 419 μM for inhibitingIC50
-mediated Ca influxTRPV4 2+
Purity 9945Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2193874Cat No HY-100720
GSK2193874 is an orally active potent andselective antagonist with s of 2 nM andTRPV4 IC50
40 nM for and rTRPV4 hTRPV4
Purity 9968Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg
GSK2798745Cat No HY-19765
GSK2798745 is a first-in-class highly potentselective orally active transient receptorpotential vanilloid 4 blocker(TRPV4) ion channelwith s of 18 and 16 nM for hTRPV4 andIC50
rTRPV4 respectively
Purity 9827Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg
GSK3395879Cat No HY-112202
GSK3395879 is a selective and orally bioavailabletransient receptor potential vanilloid-4 ( )TRPV4antagonist with an of 1 nM for hTRPV4IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
HC-030031Cat No HY-15064
HC-030031 is a potent and selective TRPA1inhibitor which antagonizes AITC- andformalin-evoked calcium influx with s ofIC50
62plusmn02 and 53plusmn02 μM respectively
Purity 9591Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg
HC-067047Cat No HY-100208
HC-067047 is a potent and selective TRPV4antagonist and reversibly inhibits currentsthrough the human rat and mouse orthologsTRPV4with values of 48 nM 133 nM and 17 nMIC50
respectively
Purity 9995Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
HC-070Cat No HY-112302
HC-070 is an antagonist of withTRPC4TRPC5s of 93 nM and 46 nM for hTRPC5 and hTRPC4 inIC50
cells respectively
Purity 9823Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Hydroxy-α-sanshoolCat No HY-N6825
Hydroxy-α-sanshool is an alkylamide isolatedfrom acts as a covalent and pepper TRPA1 TRPV1non-covalent agonist with s of 69 and 11EC50
microM respectively
Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) Cat No HY-116330A
Hyperforin dicyclohexylammonium salt (HyperforinDCHA) is a transient receptor canonical 6 (TRPC6)channels activator Hyperforindicyclohexylammonium salt modulates Ca levels2+
by activating Ca -conducting non-selective2+
canonical TRPC6 channels
Purity 9817Clinical Data No Development ReportedSize 500 μg 1 mg
6 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
IA-Alkyne (Iodoacetamide-alkyne N-Hex-5-ynyl-2-iodo-acetamide) Cat No HY-136205
IA-Alkyne (Iodoacetamide-alkyneN-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel
agonist and has the potential for the(TRPC)study of respiratory infection IA-Alkyne can beused to develop an isotopically tagged forprobequantitative profilingcysteine-reactivity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Icilin (AG-3-5) Cat No HY-11062
Icilin(AG 3-5) is a synthetic super-agonist ofTRPM8 ion channel
Purity gt960Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Imperatorin (Ammidin) Cat No HY-N0285
Imperatorin is an effective of NO synthesisinhibitor ( =92 μmol) which also is a IC50 BChEinhibitor ( =314 μmol) Imperatorin is a weakIC50
agonist of with of 126plusmn32 μMTRPV1 EC50
Purity 9581Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
JNJ-17203212Cat No HY-100129
JNJ-17203212 is a novel and selective TRPV1antagonist with IC50 of 65 nM and 102 nM forhuman TRPV1 and rat TRPV1
Purity 9994Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
JT010Cat No HY-111132
JT010 is a potent agonist of with an TRPA1 EC50
of 065 nM
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
JYL 1421 (SC 0030) Cat No HY-100668
JYL 1421 is a antagonist with anTRPV1 receptor of 8 nMIC50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
Linopirdine (DuP 996) Cat No HY-W020468
Linopirdine (DuP 996) is an orally activeselective M-type K current (IM Kv7 KCNQ+
inhibitor with an of 24 μMChannels) IC50
Linopirdine is a agonist Linopirdine aTRPV1putative cognition enhancing drug increasesacetylcholine release in rat brain tissue
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mavatrep (JNJ-39439335) Cat No HY-16935
Mavatrep is an orally bioavailable TRPV1antagonist (Ki=65 nM) exhibits minimal effect onthe enzymatic activity (IC50 gt 25 μM) of CYPisoforms 3A4 1A2 and 2D6
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
MDR-652Cat No HY-136363
MDR-652 is a highly specific and efficacious ( )transient receptor potential vanilloid 1 TRPV1
ligand with agonist activity The s are 114 andKi
238 nM for hTRPV1 and rTRPV1 respectively Thes are 505 and 93 nM for hTRPV1 and rTRPV1EC50
respectively Potent topical analgesic activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Methyl syringateCat No HY-W002116
Methyl syringate a chemical marker of asphodelmonofloral honey is an efficient phenolicmediator for bacterial and fungal laccases Methylsyringate is a agonistTRPA1
Purity 9976Clinical Data No Development ReportedSize 100 mg
wwwMedChemExpresscom 7
Mifamurtide (MTP-PE L-MTP-PE CGP 19835) Cat No HY-13682
Mifamurtide (MTP-PE CGP19835) is a drug againstosteosarcoma Mifamurtide is an immunomodulatorwith antitumor effects that appear to be mediatedvia activation of monocytes and macrophages
Purity gt990Clinical Data LaunchedSize 1 mg 5 mg 10 mg
MK6-83Cat No HY-110238
MK6-83 is a new candidate agonist of TRPML1with an improved efficacy and potency MK6-83 hasthe potential for Mucolipidosis type IV study
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
ML204Cat No HY-12949
ML204 is a novel potent antagonist thatselectively modulates native TRPC4C5 ionchannels
Purity 9831Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
ML204 hydrochlorideCat No HY-12949A
ML204 hydrochloride is a novel potent selectiveTRPC4 channel inhibitor with IC50 of 096 uMexhibit 19-fold selectivity against TRPC6 channelsin similar fluorescent assays target ML204 IC50096 uM In vitro ML204 inhibited TRPC4β-mediatedintracellular Ca2+ rise
Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) Cat No HY-118628
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is abroad spectrum inhibitorPhospholipase A (PLA )2 2
and blockerTRP channel
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Nonivamide (Pelargonic acid vanillylamide Nonanoic acid
vanillylamide Pseudocapsaicin) Cat No HY-17568
Nonivamide is a ltbltTRPV1 agonist whichexhibits 4d- value of 51 mgL in staticEC50
toxicity tests
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 5 g
OMDM-5Cat No HY-135881
OMDM-5 is a selective inhibitor of anandamide with a of 48 μMcellular uptake (ACU) Ki
OMDM-5 is also a potent vanilloid receptor type 1 agonist with an of 75 nM(VR1 TRPV1) EC50
and shows weakly active as cannabinoid receptortype 1 (CB1) ligand (K =49 μM)i
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OMDM-6Cat No HY-135882
OMDM-6 is a hybrid agonist of vanilloid receptor ( =75 nM) and type 1 (VR1 TRPV1) EC50 cannabinoid
( =32 μM) OMDM-6receptor type 1 (CB1) Ki
inhibits withanandamide cellular uptake (ACU)a of 70 μMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OptovinCat No HY-12809
Optovin is a reversible photoactive TRPA1activator stimulates human TRPA1 channels invitro and enables repeated photoactivation ofmotor behaviors in wild-type zebrafish (EC50 = 2μM)
Purity 9954Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
PF-04745637Cat No HY-120689
PF-04745637 is a potent and selective TRPA1antagonist with an of 17 nM for human TRPA1IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 9
Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
IA-Alkyne (Iodoacetamide-alkyne N-Hex-5-ynyl-2-iodo-acetamide) Cat No HY-136205
IA-Alkyne (Iodoacetamide-alkyneN-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel
agonist and has the potential for the(TRPC)study of respiratory infection IA-Alkyne can beused to develop an isotopically tagged forprobequantitative profilingcysteine-reactivity
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Icilin (AG-3-5) Cat No HY-11062
Icilin(AG 3-5) is a synthetic super-agonist ofTRPM8 ion channel
Purity gt960Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg
Imperatorin (Ammidin) Cat No HY-N0285
Imperatorin is an effective of NO synthesisinhibitor ( =92 μmol) which also is a IC50 BChEinhibitor ( =314 μmol) Imperatorin is a weakIC50
agonist of with of 126plusmn32 μMTRPV1 EC50
Purity 9581Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
JNJ-17203212Cat No HY-100129
JNJ-17203212 is a novel and selective TRPV1antagonist with IC50 of 65 nM and 102 nM forhuman TRPV1 and rat TRPV1
Purity 9994Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
JT010Cat No HY-111132
JT010 is a potent agonist of with an TRPA1 EC50
of 065 nM
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg
JYL 1421 (SC 0030) Cat No HY-100668
JYL 1421 is a antagonist with anTRPV1 receptor of 8 nMIC50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg
Linopirdine (DuP 996) Cat No HY-W020468
Linopirdine (DuP 996) is an orally activeselective M-type K current (IM Kv7 KCNQ+
inhibitor with an of 24 μMChannels) IC50
Linopirdine is a agonist Linopirdine aTRPV1putative cognition enhancing drug increasesacetylcholine release in rat brain tissue
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Mavatrep (JNJ-39439335) Cat No HY-16935
Mavatrep is an orally bioavailable TRPV1antagonist (Ki=65 nM) exhibits minimal effect onthe enzymatic activity (IC50 gt 25 μM) of CYPisoforms 3A4 1A2 and 2D6
Purity 9985Clinical Data Phase 1Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
MDR-652Cat No HY-136363
MDR-652 is a highly specific and efficacious ( )transient receptor potential vanilloid 1 TRPV1
ligand with agonist activity The s are 114 andKi
238 nM for hTRPV1 and rTRPV1 respectively Thes are 505 and 93 nM for hTRPV1 and rTRPV1EC50
respectively Potent topical analgesic activity
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
Methyl syringateCat No HY-W002116
Methyl syringate a chemical marker of asphodelmonofloral honey is an efficient phenolicmediator for bacterial and fungal laccases Methylsyringate is a agonistTRPA1
Purity 9976Clinical Data No Development ReportedSize 100 mg
wwwMedChemExpresscom 7
Mifamurtide (MTP-PE L-MTP-PE CGP 19835) Cat No HY-13682
Mifamurtide (MTP-PE CGP19835) is a drug againstosteosarcoma Mifamurtide is an immunomodulatorwith antitumor effects that appear to be mediatedvia activation of monocytes and macrophages
Purity gt990Clinical Data LaunchedSize 1 mg 5 mg 10 mg
MK6-83Cat No HY-110238
MK6-83 is a new candidate agonist of TRPML1with an improved efficacy and potency MK6-83 hasthe potential for Mucolipidosis type IV study
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
ML204Cat No HY-12949
ML204 is a novel potent antagonist thatselectively modulates native TRPC4C5 ionchannels
Purity 9831Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
ML204 hydrochlorideCat No HY-12949A
ML204 hydrochloride is a novel potent selectiveTRPC4 channel inhibitor with IC50 of 096 uMexhibit 19-fold selectivity against TRPC6 channelsin similar fluorescent assays target ML204 IC50096 uM In vitro ML204 inhibited TRPC4β-mediatedintracellular Ca2+ rise
Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) Cat No HY-118628
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is abroad spectrum inhibitorPhospholipase A (PLA )2 2
and blockerTRP channel
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Nonivamide (Pelargonic acid vanillylamide Nonanoic acid
vanillylamide Pseudocapsaicin) Cat No HY-17568
Nonivamide is a ltbltTRPV1 agonist whichexhibits 4d- value of 51 mgL in staticEC50
toxicity tests
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 5 g
OMDM-5Cat No HY-135881
OMDM-5 is a selective inhibitor of anandamide with a of 48 μMcellular uptake (ACU) Ki
OMDM-5 is also a potent vanilloid receptor type 1 agonist with an of 75 nM(VR1 TRPV1) EC50
and shows weakly active as cannabinoid receptortype 1 (CB1) ligand (K =49 μM)i
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OMDM-6Cat No HY-135882
OMDM-6 is a hybrid agonist of vanilloid receptor ( =75 nM) and type 1 (VR1 TRPV1) EC50 cannabinoid
( =32 μM) OMDM-6receptor type 1 (CB1) Ki
inhibits withanandamide cellular uptake (ACU)a of 70 μMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OptovinCat No HY-12809
Optovin is a reversible photoactive TRPA1activator stimulates human TRPA1 channels invitro and enables repeated photoactivation ofmotor behaviors in wild-type zebrafish (EC50 = 2μM)
Purity 9954Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
PF-04745637Cat No HY-120689
PF-04745637 is a potent and selective TRPA1antagonist with an of 17 nM for human TRPA1IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 9
Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
Mifamurtide (MTP-PE L-MTP-PE CGP 19835) Cat No HY-13682
Mifamurtide (MTP-PE CGP19835) is a drug againstosteosarcoma Mifamurtide is an immunomodulatorwith antitumor effects that appear to be mediatedvia activation of monocytes and macrophages
Purity gt990Clinical Data LaunchedSize 1 mg 5 mg 10 mg
MK6-83Cat No HY-110238
MK6-83 is a new candidate agonist of TRPML1with an improved efficacy and potency MK6-83 hasthe potential for Mucolipidosis type IV study
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
ML204Cat No HY-12949
ML204 is a novel potent antagonist thatselectively modulates native TRPC4C5 ionchannels
Purity 9831Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
ML204 hydrochlorideCat No HY-12949A
ML204 hydrochloride is a novel potent selectiveTRPC4 channel inhibitor with IC50 of 096 uMexhibit 19-fold selectivity against TRPC6 channelsin similar fluorescent assays target ML204 IC50096 uM In vitro ML204 inhibited TRPC4β-mediatedintracellular Ca2+ rise
Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) Cat No HY-118628
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is abroad spectrum inhibitorPhospholipase A (PLA )2 2
and blockerTRP channel
Purity 9881Clinical Data No Development ReportedSize 10 mM times 1 mL 25 mg 50 mg 100 mg
Nonivamide (Pelargonic acid vanillylamide Nonanoic acid
vanillylamide Pseudocapsaicin) Cat No HY-17568
Nonivamide is a ltbltTRPV1 agonist whichexhibits 4d- value of 51 mgL in staticEC50
toxicity tests
Purity 9816Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 5 g
OMDM-5Cat No HY-135881
OMDM-5 is a selective inhibitor of anandamide with a of 48 μMcellular uptake (ACU) Ki
OMDM-5 is also a potent vanilloid receptor type 1 agonist with an of 75 nM(VR1 TRPV1) EC50
and shows weakly active as cannabinoid receptortype 1 (CB1) ligand (K =49 μM)i
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OMDM-6Cat No HY-135882
OMDM-6 is a hybrid agonist of vanilloid receptor ( =75 nM) and type 1 (VR1 TRPV1) EC50 cannabinoid
( =32 μM) OMDM-6receptor type 1 (CB1) Ki
inhibits withanandamide cellular uptake (ACU)a of 70 μMKi
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
OptovinCat No HY-12809
Optovin is a reversible photoactive TRPA1activator stimulates human TRPA1 channels invitro and enables repeated photoactivation ofmotor behaviors in wild-type zebrafish (EC50 = 2μM)
Purity 9954Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
PF-04745637Cat No HY-120689
PF-04745637 is a potent and selective TRPA1antagonist with an of 17 nM for human TRPA1IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 9
Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
PF-05105679Cat No HY-115506
PF-05105679 is an orally active and selective antagonist with an of 103 nMTRPM8 IC50
PF-05105679 has the potential for cold-relatedpain
Purity gt98Clinical Data Phase 1Size 1 mg 5 mg
PF-4840154Cat No HY-18779
PF-4840154 is a potent selective agonist of therat and human channel with s of 97TrpA1 EC50
and 23 nM respectively
Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Pico145 (HC-608) Cat No HY-101507
Pico145 (HC-608) is a remarkable inhibitor of channels inhibits (minus)-englerinTRPC145
A-activated TRPC4TRPC5 channels with s ofIC50
0349 and 13 nM in cells and shows no effect onTRPC3 TRPC6 TRPV1 TRPV4 TRPA1 TRPM2 TRPM8
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
Piromelatine (Neu-P11) Cat No HY-105285
Piromelatine (Neu-P11) is a melatonin receptor agonist MT MT1 2 serotonin
agonist and 5-HT1A 5-HT1D serotonin 5-HT2B
antagonist
Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
Podocarpic acidCat No HY-N2318
Podocarpic acid is a natural product which hasthe best all-round positive effect and acts as anovel activatorTRPA1
Purity 9956Clinical Data No Development ReportedSize 10 mg 50 mg
ProbenecidCat No HY-B0545
Probenecid is a potent and selective agonist oftransient receptor potential vanilloid 2 ( )TRPV2channels Probenecid also inhibits pannexin 1channels
Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g
PulegoneCat No HY-N1500
Pulegone the major chemical constituent of (L) Savi essential oil whichCalamintha nepeta
is an aromatic herb with a mint-oregano flavor isone of avian repellents The molecular target forthe repellent action of Pulegone in avian speciesis nociceptive TRP ankyrin 1 (TRPA1)
Purity 9966Clinical Data No Development ReportedSize 5 mg
Pyr10Cat No HY-19408
Pyr10 is a pyrazole derivative and a selective inhibitor Pyr10 inhibitsTRP cation 3 (TRPC3)
Ca influx in carbachol-stimulated2+
-transfected HEK293 cells with an ofTRPC3 IC50
072 μM (IC of 1308 μM for store operated Ca502+
entry in BRL-2H3 cells)
Purity 9960Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg
Pyr3Cat No HY-108465
Pyr3 is a selective inhibitor of transientreceptor potential canonical channel 3 (TRPC3)with an of 700 nM for TRPC3-mediated CaIC50
2+
influx
Purity 9989Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg
Pyr6Cat No HY-12504
Pyr6 is a selective inhibitor of TRPC3 with IC50of 049 uM(Ca2+ influx inhibition in thapsigargindepleted native RBL-2H3 cells) IC50 value 049uM Target TRPC3 inhibitor Pyr6 is a selectiveSOCE inhibitor (Yonetoku et al 2008 Sweeney etal
Purity 9942Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
wwwMedChemExpresscom 9
Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
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Resolvin D2 (RvD2) Cat No HY-121636
Resolvin D2 is a metabolite of docosahexaenoicacid (DHA) with anti-inflammatory anti-infectiveactivities Resolvin D2 is a potent regulator ofleukocytes and controls microbial sepsis
Purity gt98Clinical Data No Development ReportedSize 25 μg 50 μg
RN-1734Cat No HY-19975
RN-1734 is selective antagonist of the TRPV4 completely antagonizes 4αPDD-mediatedchannel
activation of TRPV4 with comparable lowmicromolar s for all three species (hTRPV4IC50
23 μM mTRPV4 59 μM rTRPV4 32 μM)
Purity 9901Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
RN-1747Cat No HY-19976
RN-1747 is a selective transient receptor potentialcation channel subfamily V member 4 (TRPV4)agonist with values are 077 μM 40 μMEC50
and 41 μM for hTRPV4 mTRPV4 and rTRPV4respectively RN-1747 also antagonizes TRPM8 withan IC of 4 μM50
Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg
Rosiglitazone (BRL 49653) Cat No HY-17386
Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active
agonist with s of 30 nM 100 nM andPPARγ EC50
60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd
approximately 40 nM
Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg
Rosiglitazone maleate (BRL 49653C) Cat No HY-14600
Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50
nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd
Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels
Purity 9975Clinical Data LaunchedSize 100 mg 500 mg
RQ-00203078Cat No HY-18662
RQ-00203078 is a highly selective potent andorally available TRPM8 antagonist (IC50 values are53 and 83 nM for rat and human channelsrespectively) exhibits gt350-fold selectivityfor TRPM8 over TRPV4 TRPV1 and TRPA1
Purity 9935Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SAR7334Cat No HY-15699
SAR7334 is a potent and specific inhibitorTRPC6inhibiting TRPC6 currents with of 79 nMIC50
Purity 9991Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg
SAR7334 hydrochlorideCat No HY-15699A
SAR7334 hydrochloride is a potent and specific inhibitor inhibiting TRPC6 currents withTRPC6
of 79 nMIC50
Purity 9561Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
SB-366791Cat No HY-12245
SB-366791 is a potent competitive and selectivevanilloid receptor (VR1TRPV1) antagonist withIC50 of 57plusmn12 nM target VR1TRPV1 IC 5057plusmn12 nM SB-366791 produced aconcentration-dependent inhibition of the responseto capsaicin with an apparent pKb ofhellip
Purity 9864Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg
SB-705498Cat No HY-10633
SB-705498 is a potent selective and orallybioavailable transient receptor potential vanilloid
antagonist with a of1 (TRPV1) receptor pIC50
71
Purity 9961Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
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SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
SKF-96365 hydrochlorideCat No HY-100001
SKF-96365 hydrochloride is a non-selective TRP blockerChannel
Purity 9944Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg
SN 2Cat No HY-16696
SN 2 is a novel and potent activator of TRPML3ion channel with of 18plusmn013 μMEC50
Purity 9999Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg
TC-I 2014Cat No HY-110199
TC-I 2014 (compound 5) is a potent and orallyactive Benzimidazole-containing transient receptor
antagonist withpotential melastatin 8 (TRPM8) values of 08 nM 30 nM and 44 nM forIC50
canine human and rat channels respectively
Purity gt990Clinical Data No Development ReportedSize 5 mg
TRPA1 Antagonist 1Cat No HY-111494
TRPA1 Antagonist 1 is a methylene phosphateprodrug which converts to its active parent druga antagonist with an of 8 nMTRPA1 IC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-IN-1Cat No HY-101547
TRPC6-IN-1 is a Transient Receptor PotentialCanonical 6 Channel inhibitor with an(TRPC6)
of 466 μMEC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPC6-PAM-C20Cat No HY-136190
TRPC6-PAM-C20 is a selective positiveTRPC6allosteric modulator TRPC6-PAM-C20 selectivelyactivates TRPC6 over other TRP channels and alsoactivates TRPA1 TRPC6-PAM-C20 induces transientincrease in intracellular Ca in HEK cells2+
expressing TRPC6 ( =237 μM)EC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPM8 antagonist 2Cat No HY-112430
TRPM8 antagonist 2 is a potent and selective antagonist with an of 02 nM usedTRPM8 IC50
in the research of neuropathic pain syndromes
Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg
TRPM8 antagonist WS-3Cat No HY-W014325
TRPM8 antagonist WS-3 is an agonist of TRPM8with an of 37 μMEC50
Purity 9921Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg
TRPV antagonist 1Cat No HY-U00330
TRPV antagonist 1 is a transient receptorpotential vanilloid antagonist with an(TRPV)
of lt 250 nMIC50
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
TRPV4 agonist-1Cat No HY-114400
TRPV4 agonist-1 is a transient receptor potentialvanilloid 4 (TRPV4) agonist with an EC of 60 nM50
in the hTRPV4 Ca assay2+
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
wwwMedChemExpresscom 11
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom
UmbelluloneCat No HY-135013
Umbellulone is an active constituent of the leavesof UmbelluloneUmbellularia californicastimulates the in a subset ofTRPA1 channelpeptidergic nociceptive neurons activating thetrigeminovascular system via this mechanism
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
Vanilloid receptor antagonist 1Cat No HY-114017
Vanilloid receptor antagonist 1 is a potentvanilloid receptor antagonist extractedTRPV1from patent US8349852B2 compound B8
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
WS-12Cat No HY-108449
WS-12 is an agonist of with an ofTRPM8 EC50
39 nM
Purity 9903Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg
α-SpinasterolCat No HY-N6962
α-Spinasterol isolated from hasSpinacia oleraceaantibacterial activity α-Spinasterol is atransient receptor potential vanilloid 1 ( )TRPV1antagonist has anti-inflammatory antidepressantantioxidant and antinociceptive effects
Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg
12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom